1383:
861:
503:"Identification of the 2-hydroxyglutarate and isovaleryl-CoA dehydrogenases as alternative electron donors linking lysine catabolism to the electron transport chain of Arabidopsis mitochondria"
235:
856:
452:"Two D-2-hydroxy-acid dehydrogenases in Arabidopsis thaliana with catalytic capacities to participate in the last reactions of the methylglyoxal and beta-oxidation pathways"
1017:
671:
151:
911:
170:
705:
946:
906:
1440:
791:
734:
846:
1464:
664:
501:
AraĂşjo WL, Ishizaki K, Nunes-Nesi A, Larson TR, Tohge T, Krahnert I, Witt S, Obata T, Schauer N, Graham IA, Leaver CJ, Fernie AR (May 2010).
941:
901:
381:
951:
918:
1045:
806:
719:
361:
1102:
801:
701:
163:
657:
714:
130:
1040:
866:
106:
1258:
851:
1433:
1373:
879:
1012:
776:
366:
781:
376:
371:
339:
335:
246:
1243:
1359:
1346:
1333:
1320:
1307:
1294:
1281:
1055:
1027:
999:
961:
928:
831:
697:
124:
1253:
552:"Plant D-2-hydroxyglutarate dehydrogenase participates in the catabolism of lysine especially during senescence"
1426:
1207:
1150:
821:
688:
242:
196:
29:
111:
1155:
979:
786:
871:
684:
175:
342:
whereas plants seem to be to a large extent unaffected by high cellular concentrations of this compound.
220:
99:
1469:
1176:
1095:
1064:
826:
724:
1248:
841:
836:
796:
330:
649:
550:
Engqvist MK, Kuhn A, Wienstroer J, Weber K, Jansen EE, Jakobs C, Weber AP, Maurino VG (April 2011).
127:
1212:
729:
254:
51:
1459:
1145:
816:
811:
637:
583:
532:
483:
432:
250:
211:
118:
1410:
1191:
1186:
1160:
1088:
984:
771:
627:
619:
573:
563:
522:
514:
473:
463:
422:
414:
262:
87:
401:
Achouri Y, Noël G, Vertommen D, Rider MH, Veiga-Da-Cunha M, Van
Schaftingen E (July 2004).
1238:
1222:
1135:
989:
974:
281:
63:
34:
1387:
1276:
1217:
680:
632:
607:
578:
551:
527:
502:
478:
451:
427:
402:
277:
258:
146:
1453:
1181:
1140:
1130:
280:, specifically those acting on the CH-OH group of donor with other acceptors. The
1354:
1289:
1125:
1382:
932:
884:
188:
1328:
1302:
1003:
568:
468:
207:
889:
641:
587:
536:
518:
487:
436:
268:
The enzyme activity has been confirmed in animals as well as in plants .
199:
75:
1031:
744:
418:
94:
1406:
1403:
1341:
1111:
1069:
965:
764:
759:
754:
749:
739:
623:
356:
351:
325:
203:
158:
70:
58:
46:
450:
Engqvist M, Drincovich MF, FlĂĽgge UI, Maurino VG (September 2009).
1315:
894:
403:"Identification of a dehydrogenase acting on D-2-hydroxyglutarate"
82:
1084:
653:
338:. In humans this results in the fatal neurometabolic disorder
862:
Malate dehydrogenase (oxaloacetate-decarboxylating) (NADP+)
1080:
224:
1414:
1371:
223:
1267:
1231:
1200:
1169:
1118:
1054:
1026:
998:
960:
927:
857:
Malate dehydrogenase (oxaloacetate-decarboxylating)
696:
299:
alpha-hydroxyglutarate dehydrogenase (NAD specific)
169:
157:
145:
140:
117:
105:
93:
81:
69:
57:
45:
40:
28:
23:
18:
1018:Vitamin-K-epoxide reductase (warfarin-insensitive)
293:(R)-2-hydroxyglutarate:(acceptor) 2-oxidoreductase
229:
286:(R)-2-hydroxyglutarate:acceptor 2-oxidoreductase
1434:
1096:
665:
334:(At4g36400) leads to massive accumulation of
314:D-alpha-hydroxyglutarate:NAD 2-oxidoreductase
8:
606:Maurino, Veronica; Engqvist, Martin (2015).
1441:
1427:
1103:
1089:
1081:
947:D-lactate dehydrogenase (cytochrome c-553)
672:
658:
650:
137:
631:
577:
567:
526:
477:
467:
426:
222:
792:D-malate dehydrogenase (decarboxylating)
1378:
393:
847:Malate dehydrogenase (decarboxylating)
311:D-alpha-hydroxyglutarate dehydrogenase
15:
608:"2-Hydroxy Acids in Plant Metabolism"
324:Deficiency in this enzyme in humans (
302:alpha-hydroxyglutarate oxidoreductase
288:. Other names in common use include:
276:This enzyme belongs to the family of
7:
1399:
1397:
942:D-lactate dehydrogenase (cytochrome)
382:Hydroxyacid-oxoacid transhydrogenase
296:alpha-hydroxyglutarate dehydrogenase
952:Mannitol dehydrogenase (cytochrome)
230:{\displaystyle \rightleftharpoons }
1413:. You can help Knowledge (XXG) by
1046:Quinoprotein glucose dehydrogenase
807:Glycerol-3-phosphate dehydrogenase
720:3-hydroxybutyryl-CoA dehydrogenase
362:L-2-hydroxyglutarate dehydrogenase
217:(R)-2-hydroxyglutarate + acceptor
193:D-2-hydroxyglutarate dehydrogenase
19:D-2-hydroxyglutarate dehydrogenase
14:
802:Glucose-6-phosphate dehydrogenase
237:2-oxoglutarate + reduced acceptor
1381:
715:3-hydroxyacyl-CoA dehydrogenase
1041:Malate dehydrogenase (quinone)
867:Phosphogluconate dehydrogenase
1:
308:hydroxyglutaric dehydrogenase
305:alpha-ketoglutarate reductase
1465:Enzymes of unknown structure
880:Hydroxysteroid dehydrogenase
852:Malate dehydrogenase (NADP+)
1013:Vitamin K epoxide reductase
782:Carbohydrate dehydrogenases
777:Beta-Ketoacyl ACP reductase
367:2-hydroxyglutarate synthase
1486:
1396:
377:2-Hydroxyglutaric aciduria
372:Alpha-Hydroxyglutaric acid
340:2-Hydroxyglutaric aciduria
1259:Michaelis–Menten kinetics
832:L-threonine dehydrogenase
136:
1151:Diffusion-limited enzyme
822:Isocitrate dehydrogenase
562:(April 1): 11382–11390.
328:) or in the model plant
284:of this enzyme class is
980:L-gulonolactone oxidase
787:Carnitine dehydrogenase
685:alcohol oxidoreductases
569:10.1074/jbc.M110.194175
469:10.1074/jbc.M109.021253
1409:-related article is a
872:Sorbitol dehydrogenase
519:10.1105/tpc.110.075630
247:(R)-2-hydroxyglutarate
231:
1244:Eadie–Hofstee diagram
1177:Allosteric regulation
1065:Choline dehydrogenase
827:Lactate dehydrogenase
725:Alcohol dehydrogenase
320:Clinical significance
232:
1254:Lineweaver–Burk plot
842:Malate dehydrogenase
837:L-xylulose reductase
797:DXP reductoisomerase
612:The Arabidopsis Book
336:D-2-hydroxyglutarate
331:Arabidopsis thaliana
221:
730:Aldo-keto reductase
245:of this enzyme are
1213:Enzyme superfamily
1146:Enzyme promiscuity
419:10.1042/BJ20031933
253:, whereas its two
227:
1422:
1421:
1369:
1368:
1078:
1077:
1058:: other acceptors
1034:/similar acceptor
817:IMP dehydrogenase
812:HMG-CoA reductase
212:chemical reaction
185:
184:
181:
180:
100:metabolic pathway
1477:
1443:
1436:
1429:
1398:
1386:
1385:
1377:
1249:Hanes–Woolf plot
1192:Enzyme activator
1187:Enzyme inhibitor
1161:Enzyme catalysis
1105:
1098:
1091:
1082:
985:Xanthine oxidase
772:Aldose reductase
674:
667:
660:
651:
645:
635:
624:10.1199/tab.0182
592:
591:
581:
571:
547:
541:
540:
530:
498:
492:
491:
481:
471:
462:(37): 25026–37.
447:
441:
440:
430:
398:
263:reduced acceptor
236:
234:
233:
228:
138:
16:
1485:
1484:
1480:
1479:
1478:
1476:
1475:
1474:
1450:
1449:
1448:
1447:
1394:
1392:
1380:
1372:
1370:
1365:
1277:Oxidoreductases
1263:
1239:Enzyme kinetics
1227:
1223:List of enzymes
1196:
1165:
1136:Catalytic triad
1114:
1109:
1079:
1074:
1050:
1022:
994:
990:Alcohol oxidase
975:Glucose oxidase
956:
923:
692:
681:Oxidoreductases
678:
648:
605:
601:
599:Further reading
596:
595:
549:
548:
544:
500:
499:
495:
449:
448:
444:
413:(Pt 1): 35–42.
400:
399:
395:
390:
348:
322:
317:
282:systematic name
278:oxidoreductases
274:
219:
218:
12:
11:
5:
1483:
1481:
1473:
1472:
1467:
1462:
1452:
1451:
1446:
1445:
1438:
1431:
1423:
1420:
1419:
1391:
1390:
1367:
1366:
1364:
1363:
1350:
1337:
1324:
1311:
1298:
1285:
1271:
1269:
1265:
1264:
1262:
1261:
1256:
1251:
1246:
1241:
1235:
1233:
1229:
1228:
1226:
1225:
1220:
1215:
1210:
1204:
1202:
1201:Classification
1198:
1197:
1195:
1194:
1189:
1184:
1179:
1173:
1171:
1167:
1166:
1164:
1163:
1158:
1153:
1148:
1143:
1138:
1133:
1128:
1122:
1120:
1116:
1115:
1110:
1108:
1107:
1100:
1093:
1085:
1076:
1075:
1073:
1072:
1067:
1061:
1059:
1052:
1051:
1049:
1048:
1043:
1037:
1035:
1024:
1023:
1021:
1020:
1015:
1009:
1007:
996:
995:
993:
992:
987:
982:
977:
971:
969:
958:
957:
955:
954:
949:
944:
938:
936:
925:
924:
922:
921:
916:
915:
914:
909:
899:
898:
897:
892:
875:
874:
869:
864:
859:
854:
849:
844:
839:
834:
829:
824:
819:
814:
809:
804:
799:
794:
789:
784:
779:
774:
769:
768:
767:
762:
757:
752:
747:
742:
737:
727:
722:
717:
711:
709:
694:
693:
679:
677:
676:
669:
662:
654:
647:
646:
602:
600:
597:
594:
593:
542:
513:(5): 1549–63.
493:
442:
392:
391:
389:
386:
385:
384:
379:
374:
369:
364:
359:
354:
347:
344:
321:
318:
316:
315:
312:
309:
306:
303:
300:
297:
294:
290:
273:
270:
259:2-oxoglutarate
241:Thus, the two
239:
238:
226:
183:
182:
179:
178:
173:
167:
166:
161:
155:
154:
149:
143:
142:
134:
133:
122:
115:
114:
109:
103:
102:
97:
91:
90:
85:
79:
78:
73:
67:
66:
61:
55:
54:
49:
43:
42:
38:
37:
32:
26:
25:
21:
20:
13:
10:
9:
6:
4:
3:
2:
1482:
1471:
1468:
1466:
1463:
1461:
1458:
1457:
1455:
1444:
1439:
1437:
1432:
1430:
1425:
1424:
1418:
1416:
1412:
1408:
1405:
1400:
1395:
1389:
1384:
1379:
1375:
1361:
1357:
1356:
1351:
1348:
1344:
1343:
1338:
1335:
1331:
1330:
1325:
1322:
1318:
1317:
1312:
1309:
1305:
1304:
1299:
1296:
1292:
1291:
1286:
1283:
1279:
1278:
1273:
1272:
1270:
1266:
1260:
1257:
1255:
1252:
1250:
1247:
1245:
1242:
1240:
1237:
1236:
1234:
1230:
1224:
1221:
1219:
1218:Enzyme family
1216:
1214:
1211:
1209:
1206:
1205:
1203:
1199:
1193:
1190:
1188:
1185:
1183:
1182:Cooperativity
1180:
1178:
1175:
1174:
1172:
1168:
1162:
1159:
1157:
1154:
1152:
1149:
1147:
1144:
1142:
1141:Oxyanion hole
1139:
1137:
1134:
1132:
1129:
1127:
1124:
1123:
1121:
1117:
1113:
1106:
1101:
1099:
1094:
1092:
1087:
1086:
1083:
1071:
1068:
1066:
1063:
1062:
1060:
1057:
1053:
1047:
1044:
1042:
1039:
1038:
1036:
1033:
1029:
1025:
1019:
1016:
1014:
1011:
1010:
1008:
1005:
1001:
997:
991:
988:
986:
983:
981:
978:
976:
973:
972:
970:
967:
963:
959:
953:
950:
948:
945:
943:
940:
939:
937:
934:
930:
926:
920:
917:
913:
910:
908:
905:
904:
903:
900:
896:
893:
891:
888:
887:
886:
883:
881:
877:
876:
873:
870:
868:
865:
863:
860:
858:
855:
853:
850:
848:
845:
843:
840:
838:
835:
833:
830:
828:
825:
823:
820:
818:
815:
813:
810:
808:
805:
803:
800:
798:
795:
793:
790:
788:
785:
783:
780:
778:
775:
773:
770:
766:
763:
761:
758:
756:
753:
751:
748:
746:
743:
741:
738:
736:
733:
732:
731:
728:
726:
723:
721:
718:
716:
713:
712:
710:
707:
703:
699:
695:
690:
686:
682:
675:
670:
668:
663:
661:
656:
655:
652:
643:
639:
634:
629:
625:
621:
617:
613:
609:
604:
603:
598:
589:
585:
580:
575:
570:
565:
561:
557:
553:
546:
543:
538:
534:
529:
524:
520:
516:
512:
508:
504:
497:
494:
489:
485:
480:
475:
470:
465:
461:
457:
456:J. Biol. Chem
453:
446:
443:
438:
434:
429:
424:
420:
416:
412:
408:
404:
397:
394:
387:
383:
380:
378:
375:
373:
370:
368:
365:
363:
360:
358:
355:
353:
350:
349:
345:
343:
341:
337:
333:
332:
327:
319:
313:
310:
307:
304:
301:
298:
295:
292:
291:
289:
287:
283:
279:
271:
269:
266:
264:
260:
256:
252:
248:
244:
216:
215:
214:
213:
209:
205:
201:
198:
194:
190:
177:
174:
172:
168:
165:
162:
160:
156:
153:
150:
148:
144:
139:
135:
132:
129:
126:
123:
120:
116:
113:
110:
108:
104:
101:
98:
96:
92:
89:
86:
84:
80:
77:
76:NiceZyme view
74:
72:
68:
65:
62:
60:
56:
53:
50:
48:
44:
39:
36:
33:
31:
27:
22:
17:
1470:EC 1.1 stubs
1415:expanding it
1401:
1393:
1355:Translocases
1352:
1339:
1326:
1313:
1300:
1290:Transferases
1287:
1274:
1131:Binding site
878:
615:
611:
559:
555:
545:
510:
506:
496:
459:
455:
445:
410:
406:
396:
329:
323:
285:
275:
272:Nomenclature
267:
240:
192:
186:
64:BRENDA entry
1126:Active site
1006:as acceptor
556:J Biol Chem
52:IntEnz view
24:Identifiers
1454:Categories
1329:Isomerases
1303:Hydrolases
1170:Regulation
933:cytochrome
507:Plant Cell
407:Biochem. J
388:References
243:substrates
189:enzymology
121:structures
88:KEGG entry
1460:EC 1.1.99
1208:EC number
1004:disulfide
618:: e0182.
225:⇌
208:catalyzes
200:1.1.99.39
41:Databases
35:1.1.99.39
1232:Kinetics
1156:Cofactor
1119:Activity
968:acceptor
935:acceptor
912:11β-HSD2
907:11β-HSD1
708:acceptor
642:26380567
588:21296880
537:20501910
488:19586914
437:15070399
346:See also
255:products
251:acceptor
202:) is an
176:proteins
164:articles
152:articles
125:RCSB PDB
1388:Biology
1342:Ligases
1112:Enzymes
1032:quinone
633:4568905
579:3064194
528:2899879
479:2757207
428:1133759
112:profile
95:MetaCyc
1407:enzyme
1404:EC 1.1
1374:Portal
1316:Lyases
1070:L2HGDH
1056:1.1.99
966:oxygen
890:3β-HSD
640:
630:
586:
576:
535:
525:
486:
476:
435:
425:
357:L2HGDH
352:D2HGDH
326:D2HGDH
204:enzyme
159:PubMed
141:Search
131:PDBsum
71:ExPASy
59:BRENDA
47:IntEnz
30:EC no.
1402:This
1268:Types
1028:1.1.5
1000:1.1.4
962:1.1.3
929:1.1.2
895:NSDHL
698:1.1.1
206:that
107:PRIAM
1411:stub
1360:list
1353:EC7
1347:list
1340:EC6
1334:list
1327:EC5
1321:list
1314:EC4
1308:list
1301:EC3
1295:list
1288:EC2
1282:list
1275:EC1
745:1B10
706:NADP
691:1.1)
638:PMID
584:PMID
533:PMID
484:PMID
433:PMID
261:and
257:are
249:and
210:the
191:, a
171:NCBI
128:PDBe
83:KEGG
919:17β
902:11β
765:7A2
760:1C4
755:1C3
750:1C1
740:1B1
735:1A1
702:NAD
628:PMC
620:doi
574:PMC
564:doi
560:286
523:PMC
515:doi
474:PMC
464:doi
460:284
423:PMC
415:doi
411:381
187:In
147:PMC
119:PDB
1456::
1030::
1002::
964::
931::
885:3β
700::
689:EC
683::
636:.
626:.
616:13
614:.
610:.
582:.
572:.
558:.
554:.
531:.
521:.
511:22
509:.
505:.
482:.
472:.
458:.
454:.
431:.
421:.
409:.
405:.
265:.
197:EC
1442:e
1435:t
1428:v
1417:.
1376::
1362:)
1358:(
1349:)
1345:(
1336:)
1332:(
1323:)
1319:(
1310:)
1306:(
1297:)
1293:(
1284:)
1280:(
1104:e
1097:t
1090:v
882::
704:/
687:(
673:e
666:t
659:v
644:.
622::
590:.
566::
539:.
517::
490:.
466::
439:.
417::
195:(
Text is available under the Creative Commons Attribution-ShareAlike License. Additional terms may apply.