1499:
383:
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341:
193:
901:
212:
966:
1556:
1158:
1106:
443:
289:
1072:
1580:
736:"The molecular basis of vancomycin resistance in clinically relevant Enterococci: crystal structure of D-alanyl-D-lactate ligase (VanA)"
894:
1218:
1173:
799:"Enzymatic synthesis of the peptide in bacterial uridine nucleotides II. Enzymatic synthesis and addition of D-alanyl-D-alanine"
205:
1178:
1168:
1062:
132:
1374:
1185:
1011:
515:
361:
156:
1549:
887:
1489:
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640:
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986:
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1475:
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1449:
1436:
1423:
1410:
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1143:
1082:
1053:
936:
927:
1369:
1036:
961:
946:
1542:
1323:
1266:
918:
582:
536:
150:
43:
1016:
996:
981:
941:
503:
349:
1271:
137:
1041:
1021:
1001:
1133:
586:
837:
van
Heijenoort J (2001). "Recent advances in the formation of the bacterial peptidoglycan monomer unit".
619:, specifically those forming carbon-nitrogen bonds as acid-D-amino-acid ligases (peptide synthases). The
560:
1585:
1292:
1211:
1163:
606:
598:
217:
1364:
499:
345:
125:
1091:
747:
636:
456:
302:
60:
1328:
662:
594:
55:
153:
1261:
678:
77:
1575:
854:
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682:
551:
490:
336:
144:
1526:
879:
1307:
1302:
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1096:
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810:
765:
755:
659:
652:
482:
328:
1354:
1338:
1251:
620:
113:
17:
751:
89:
1503:
1392:
1333:
1138:
539:
188:
48:
815:
798:
168:
1569:
1297:
1256:
770:
735:
658:
The N-terminal region of the D-alanine—D-alanine ligase is thought to be involved in
648:
448:
294:
163:
411:
270:
1246:
478:
324:
424:
875:
436:
282:
1470:
1405:
1241:
644:
172:
1498:
528:
233:
1444:
1418:
666:
613:
602:
590:
547:
858:
779:
760:
452:
382:
298:
241:
871:
431:
387:
complex of y216f d-ala:d-ala ligase with adp and a phosphoryl phosphinate
277:
246:
complex of y216f d-ala:d-ala ligase with adp and a phosphoryl phosphinate
120:
101:
1522:
1519:
1457:
1227:
1101:
914:
910:
850:
616:
543:
510:
356:
200:
96:
84:
72:
1431:
1111:
1126:
1116:
867:
824:
Neuhaus FC (1962). "Kinetic studies on D-Ala-D-Ala synthetase".
472:
418:
406:
318:
265:
108:
1200:
883:
1196:
564:
1530:
866:
This article incorporates text from the public domain
1487:
734:
Roper DI, Huyton T, Vagin A, Dodson G (August 2000).
563:
1383:
1347:
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143:
131:
119:
107:
95:
83:
71:
66:
54:
42:
37:
32:
569:
681:have been solved for this class of enzymes, with
1550:
1212:
895:
8:
1557:
1543:
1219:
1205:
1197:
902:
888:
880:
665:, while the C-terminus is thought to be a
463:
381:
309:
240:
179:
814:
769:
759:
562:
625:D-alanine:D-alanine ligase (ADP-forming)
1494:
726:
372:
228:
29:
967:D-alanine—poly(phosphoribitol) ligase
612:This enzyme belongs to the family of
27:Enzyme belonging to the ligase family
7:
1515:
1513:
629:alanine:alanine ligase (ADP-forming)
627:. Other names in common use include
577:ADP + phosphate + D-alanyl-D-alanine
570:{\displaystyle \rightleftharpoons }
1529:. You can help Knowledge (XXG) by
1107:Von Hippel–Lindau tumor suppressor
25:
1497:
1073:Long-chain-fatty-acid—CoA ligase
1169:Carbamoyl phosphate synthetase
1063:Succinyl coenzyme A synthetase
797:Ito, E; Strominger JL (1962).
635:. This enzyme participates in
1:
816:10.1016/S0021-9258(19)73809-5
467:Available protein structures:
376:D-ala D-ala ligase C-terminus
313:Available protein structures:
740:Proc. Natl. Acad. Sci. U.S.A
1602:
1581:Enzymes of known structure
1512:
1154:Holocarboxylase synthetase
1149:Argininosuccinate synthase
1122:Anaphase-promoting complex
865:
641:peptidoglycan biosynthesis
533:D-alanine—D-alanine ligase
33:D-Alanine—D-alanine ligase
18:D-alanine-D-alanine ligase
1375:Michaelis–Menten kinetics
1186:Glutamate–cysteine ligase
1144:Adenylosuccinate synthase
937:Aminoacyl tRNA synthetase
462:
380:
308:
239:
178:
1267:Diffusion-limited enzyme
633:alanylalanine synthetase
623:of this enzyme class is
1525:-related article is a
1134:Glutathione synthetase
761:10.1073/pnas.150116497
571:
1360:Eadie–Hofstee diagram
1293:Allosteric regulation
1164:Asparagine synthetase
1068:Acetyl—CoA synthetase
572:
1370:Lineweaver–Burk plot
1092:Glutamine synthetase
637:d-alanine metabolism
561:
752:2000PNAS...97.8921R
677:As of late 2007, 8
653:inhibit this enzyme
585:of this enzyme are
232:D-ala D-ala ligase
1329:Enzyme superfamily
1262:Enzyme promiscuity
673:Structural studies
607:D-alanyl-D-alanine
567:
557:ATP + 2 D-alanine
1538:
1537:
1485:
1484:
1194:
1193:
1085:: Carbon-Nitrogen
552:chemical reaction
525:
524:
521:
520:
516:structure summary
371:
370:
367:
366:
362:structure summary
227:
226:
223:
222:
126:metabolic pathway
16:(Redirected from
1593:
1559:
1552:
1545:
1514:
1502:
1501:
1493:
1365:Hanes–Woolf plot
1308:Enzyme activator
1303:Enzyme inhibitor
1277:Enzyme catalysis
1221:
1214:
1207:
1198:
1097:Ubiquitin ligase
904:
897:
890:
881:
862:
851:10.1039/a804532a
833:
820:
818:
784:
783:
773:
763:
731:
685:accession codes
593:, whereas its 3
576:
574:
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568:
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385:
373:
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244:
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30:
21:
1601:
1600:
1596:
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1590:
1566:
1565:
1564:
1563:
1510:
1508:
1496:
1488:
1486:
1481:
1393:Oxidoreductases
1379:
1355:Enzyme kinetics
1343:
1339:List of enzymes
1312:
1281:
1252:Catalytic triad
1230:
1225:
1195:
1190:
1077:
1056:: Carbon-Sulfur
1048:
930:: Carbon-Oxygen
922:
913:: CO CS and CN
908:
878:
836:
823:
796:
793:
791:Further reading
788:
787:
733:
732:
728:
723:
675:
621:systematic name
559:
558:
401:Dala_Dala_lig_C
388:
260:Dala_Dala_lig_N
247:
28:
23:
22:
15:
12:
11:
5:
1599:
1597:
1589:
1588:
1583:
1578:
1568:
1567:
1562:
1561:
1554:
1547:
1539:
1536:
1535:
1507:
1506:
1483:
1482:
1480:
1479:
1466:
1453:
1440:
1427:
1414:
1401:
1387:
1385:
1381:
1380:
1378:
1377:
1372:
1367:
1362:
1357:
1351:
1349:
1345:
1344:
1342:
1341:
1336:
1331:
1326:
1320:
1318:
1317:Classification
1314:
1313:
1311:
1310:
1305:
1300:
1295:
1289:
1287:
1283:
1282:
1280:
1279:
1274:
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1264:
1259:
1254:
1249:
1244:
1238:
1236:
1232:
1231:
1226:
1224:
1223:
1216:
1209:
1201:
1192:
1191:
1189:
1188:
1183:
1182:
1181:
1176:
1166:
1161:
1156:
1151:
1146:
1141:
1139:CTP synthetase
1136:
1131:
1130:
1129:
1124:
1119:
1114:
1109:
1104:
1094:
1088:
1086:
1079:
1078:
1076:
1075:
1070:
1065:
1059:
1057:
1050:
1049:
1047:
1046:
1045:
1044:
1039:
1034:
1029:
1024:
1019:
1014:
1009:
1004:
999:
994:
989:
984:
979:
974:
969:
964:
959:
954:
949:
944:
933:
931:
924:
923:
909:
907:
906:
899:
892:
884:
864:
863:
839:Nat. Prod. Rep
834:
821:
792:
789:
786:
785:
746:(16): 8921–5.
725:
724:
722:
719:
674:
671:
581:Thus, the two
579:
578:
566:
523:
522:
519:
518:
513:
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506:
493:
487:
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476:
469:
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368:
365:
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105:
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58:
52:
51:
46:
40:
39:
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34:
26:
24:
14:
13:
10:
9:
6:
4:
3:
2:
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1587:
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1511:
1505:
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1495:
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1477:
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1467:
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1447:
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1421:
1420:
1415:
1412:
1408:
1407:
1402:
1399:
1395:
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1389:
1388:
1386:
1382:
1376:
1373:
1371:
1368:
1366:
1363:
1361:
1358:
1356:
1353:
1352:
1350:
1346:
1340:
1337:
1335:
1334:Enzyme family
1332:
1330:
1327:
1325:
1322:
1321:
1319:
1315:
1309:
1306:
1304:
1301:
1299:
1298:Cooperativity
1296:
1294:
1291:
1290:
1288:
1284:
1278:
1275:
1273:
1270:
1268:
1265:
1263:
1260:
1258:
1257:Oxyanion hole
1255:
1253:
1250:
1248:
1245:
1243:
1240:
1239:
1237:
1233:
1229:
1222:
1217:
1215:
1210:
1208:
1203:
1202:
1199:
1187:
1184:
1180:
1177:
1175:
1172:
1171:
1170:
1167:
1165:
1162:
1160:
1157:
1155:
1152:
1150:
1147:
1145:
1142:
1140:
1137:
1135:
1132:
1128:
1125:
1123:
1120:
1118:
1115:
1113:
1110:
1108:
1105:
1103:
1100:
1099:
1098:
1095:
1093:
1090:
1089:
1087:
1084:
1080:
1074:
1071:
1069:
1066:
1064:
1061:
1060:
1058:
1055:
1051:
1043:
1040:
1038:
1035:
1033:
1030:
1028:
1025:
1023:
1020:
1018:
1015:
1013:
1012:Phenylalanine
1010:
1008:
1005:
1003:
1000:
998:
995:
993:
990:
988:
985:
983:
980:
978:
975:
973:
970:
968:
965:
963:
960:
958:
955:
953:
950:
948:
945:
943:
940:
939:
938:
935:
934:
932:
929:
925:
920:
916:
912:
905:
900:
898:
893:
891:
886:
885:
882:
877:
873:
869:
860:
856:
852:
848:
845:(5): 503–19.
844:
840:
835:
831:
827:
822:
817:
812:
809:: 2696–2703.
808:
804:
803:J. Biol. Chem
800:
795:
794:
790:
781:
777:
772:
767:
762:
757:
753:
749:
745:
741:
737:
730:
727:
720:
718:
716:
712:
708:
704:
700:
696:
692:
688:
684:
680:
672:
670:
668:
664:
661:
656:
654:
651:are known to
650:
649:D-cycloserine
646:
642:
638:
634:
630:
626:
622:
618:
615:
610:
608:
604:
600:
596:
592:
588:
584:
556:
555:
554:
553:
549:
545:
541:
538:
534:
530:
517:
514:
512:
508:
505:
501:
497:
494:
492:
488:
484:
480:
477:
474:
470:
465:
461:
458:
454:
450:
447:
445:
441:
438:
435:
433:
429:
426:
423:
420:
416:
413:
410:
408:
404:
400:
396:
391:
384:
379:
374:
363:
360:
358:
354:
351:
347:
343:
340:
338:
334:
330:
326:
323:
320:
316:
311:
307:
304:
300:
296:
293:
291:
287:
284:
281:
279:
275:
272:
269:
267:
263:
259:
255:
250:
243:
238:
235:
230:
219:
216:
214:
210:
207:
204:
202:
198:
195:
192:
190:
186:
181:
177:
174:
170:
167:
165:
164:Gene Ontology
161:
158:
155:
152:
149:
146:
142:
139:
136:
134:
130:
127:
124:
122:
118:
115:
112:
110:
106:
103:
102:NiceZyme view
100:
98:
94:
91:
88:
86:
82:
79:
76:
74:
70:
65:
62:
59:
57:
53:
50:
47:
45:
41:
36:
31:
19:
1586:Ligase stubs
1531:expanding it
1517:
1509:
1471:Translocases
1468:
1455:
1442:
1429:
1416:
1406:Transferases
1403:
1390:
1247:Binding site
1159:GMP synthase
842:
838:
829:
825:
806:
802:
743:
739:
729:
676:
657:
632:
628:
624:
611:
580:
532:
526:
90:BRENDA entry
1242:Active site
645:Phosphinate
393:Identifiers
252:Identifiers
78:IntEnz view
38:Identifiers
1570:Categories
1445:Isomerases
1419:Hydrolases
1286:Regulation
1032:Tryptophan
1007:Methionine
992:Isoleucine
952:Asparagine
721:References
679:structures
583:substrates
529:enzymology
479:structures
325:structures
234:N-terminus
147:structures
114:KEGG entry
61:9023-63-6
1324:EC number
1027:Threonine
987:Histidine
977:Glutamine
972:Glutamate
957:Aspartate
876:IPR011127
826:Fed. Proc
667:catalytic
660:substrate
614:ATP-grasp
603:phosphate
591:D-alanine
565:⇌
548:catalyzes
437:IPR011095
283:IPR011127
67:Databases
1576:EC 6.3.2
1348:Kinetics
1272:Cofactor
1235:Activity
1037:Tyrosine
962:Cysteine
947:Arginine
921:6.1-6.3)
872:InterPro
859:11699883
780:10908650
669:domain.
595:products
542:) is an
496:RCSB PDB
432:InterPro
342:RCSB PDB
278:InterPro
218:proteins
206:articles
194:articles
151:RCSB PDB
1504:Biology
1458:Ligases
1228:Enzymes
1017:Proline
997:Leucine
982:Glycine
942:Alanine
915:ligases
911:Enzymes
748:Bibcode
663:binding
617:ligases
540:6.3.2.4
412:PF07478
271:PF01820
173:QuickGO
138:profile
121:MetaCyc
56:CAS no.
49:6.3.2.4
1523:enzyme
1520:EC 6.3
1490:Portal
1432:Lyases
1102:Cullin
1042:Valine
1022:Serine
1002:Lysine
857:
832:: 229.
778:
768:
713:, and
631:, and
605:, and
544:enzyme
511:PDBsum
485:
475:
457:SUPFAM
425:CL0179
398:Symbol
357:PDBsum
331:
321:
303:SUPFAM
257:Symbol
201:PubMed
183:Search
169:AmiGO
157:PDBsum
97:ExPASy
85:BRENDA
73:IntEnz
44:EC no.
1518:This
1384:Types
1112:UBE3A
771:16797
546:that
453:SCOPe
444:SCOP2
299:SCOPe
290:SCOP2
133:PRIAM
1527:stub
1476:list
1469:EC7
1463:list
1456:EC6
1450:list
1443:EC5
1437:list
1430:EC4
1424:list
1417:EC3
1411:list
1404:EC2
1398:list
1391:EC1
1127:UBR1
1117:Mdm2
870:and
868:Pfam
855:PMID
776:PMID
715:2I8C
711:2I87
707:2I80
703:2FB9
699:2DLN
695:1IOW
691:1IOV
687:1EHI
647:and
639:and
597:are
589:and
550:the
531:, a
504:PDBj
500:PDBe
483:ECOD
473:Pfam
449:2dln
421:clan
419:Pfam
407:Pfam
350:PDBj
346:PDBe
329:ECOD
319:Pfam
295:2dln
266:Pfam
213:NCBI
154:PDBe
109:KEGG
1083:6.3
1054:6.2
928:6.1
847:doi
811:doi
807:237
766:PMC
756:doi
683:PDB
599:ADP
587:ATP
527:In
491:PDB
337:PDB
189:PMC
145:PDB
1572::
1179:II
919:EC
874::
853:.
843:18
841:.
830:21
828:.
805:.
801:.
774:.
764:.
754:.
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