31:
285:. He also found that these proteins operate by regulating protein translation, directly binding to the ribosomes—which are the cellular machinery that translate RNA messages into protein products—to alter their assembly. He completed his dissertation "The reaper tales: molecular mechanism of inhibition of translation and induction of apoptosis by a novel family of reaper-like proteins" in 2003. He dedicated his thesis dissertation
357:, Colón-Ramos has developed a mobile application and collaborative platform called WormGUIDES to act as a systems-level resource to track and detail neuronal connections in the nematode worm. The resource uses a combination of microscopy and single-cell tracking technologies to record the decisions of embryonic neurons of the nematode worm over the course of development. The effort, funded by the
437:(CienciaPR) to connect Puerto Rican scientists across the diaspora to promote scholarly interaction, provide visibility for Puerto Rican scientists, and support research and education in Puerto Rico. The project began first as a database and has since grown into a nonprofit organization, now led by Executive Director
476:
about a Puerto Rican
Supreme Court ruling against the right of a lesbian couple to adopt a child. The ruling cited that homosexual behavior was "unnatural;" the op-ed argued against this idea, using scientific evidence to support LGBT rights. Together with the Mexican-American surgeon and researcher
331:. In 2013, he was promoted to associate professor, and in 2019 to full professor. His research centers on the underlying mechanisms that allow animals to form memories. Specifically, his research group studies how connections between neurons, otherwise known as the
335:, are precisely made to build the right neuronal architecture, how they are maintained and how they are modified to code a particular behavior or memory. To understand how neurons find and connect to each other in the right way, his group uses the nematode worm
341:
as a model system. His laboratory has developed genetic screens to identify pathways through which synapses are formed, as well as techniques to re-route how pathways are formed by manipulating single cells to track how those changes influence behavior.
361:, aims to catalyze the development of new technologies for advancing neuroscience research, while building a platform for knowledge sharing to build a neurodevelopmental atlas mapping all the nematode cells during development.
1084:
Colón-Ramos, Daniel A.; Craig, David; Flores-Otero, Jacqueline; Fortis-Santiago, Yaihara; Díaz-Muñoz, Samuel L.; López, Marcos; Díaz-Muñoz, Greetchen; González-Espada, Wilson; Feliú-Mójer, Mónica (2013-12-31).
934:
784:
310:
are established and modified to form memories over the course of the worm's life, he established a system to track synapses over the worms development using cellular markers. Using this system, he found that
464:. In 2013, he wrote about the lack of accountability and necessary public health interventions in Vieques, whose residents suffer from poor health outcomes due to military contamination with pollutants like
287:"To those who could have done a better job than I, but never received the opportunities...may they (one day) receive the opportunities to share their knowledge and their skills in a society w/o prejudices"
354:
653:
Colón-Ramos, Daniel A.; Irusta, Pablo M.; Gan, Eugene C.; Olson, Michael R.; Song, Jaewhan; Morimoto, Richard I.; Elliott, Richard M.; Lombard, Mark; Hollingsworth, Robert (October 2003).
452:
Colón-Ramos has also authored op-eds advocating for the place of rigorous science in policy in Puerto Rico, for instance, criticizing the flawed scientific findings generated by the
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524:
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252:
in 1998. During his undergraduate career, he pursued research projects, such as studying the use of medicinal plants among indigenous
Central American communities with the
445:
Early Career Award for Public
Engagement with Science in part because of his work with CienciaPR and with promoting culturally relevant science education. In 2015, the
453:
30:
1446:
875:
Santella, Anthony; Catena, Raúl; Kovacevic, Ismar; Shah, Pavak; Yu, Zidong; Marquina-Solis, Javier; Kumar, Abhishek; Wu, Yicong; Schaff, James (2015-06-09).
241:
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346:
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Colón-Ramos, Daniel A.; Shenvi, Christina L.; Weitzel, Douglas H.; Gan, Eugene C.; Matts, Robert; Cate, Jamie; Kornbluth, Sally (February 2006).
604:
Colón-Ramos, Daniel A.; Salisbury, Jeffrey L.; Sanders, Mark A.; Shenoy, Shailesh M.; Singer, Robert H.; García-Blanco, Mariano A. (June 2003).
292:
Following his PhD, Colón-Ramos moved to
California in 2004 to pursue a postdoctoral fellowship in neuroscientist Kang Shen's laboratory as a
212:, where his lab studies the cell biology of the synapse during development and learning. He is also the founder of the nonprofit organization
770:
The reaper tales : molecular mechanism of inhibition of translation and induction of apoptosis by a novel family of reaper-like proteins
281:, and identified a viral family of proteins that induce apoptosis, which are similar to the so-called "Reaper" proteins first identified in
986:
606:"Asymmetric distribution of nuclear pore complexes and the cytoplasmic localization of beta2-tubulin mRNA in Chlamydomonas reinhardtii"
157:
The reaper tales: molecular mechanism of inhibition of translation and induction of apoptosis by a novel family of reaper-like proteins
1441:
328:
209:
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changes to affect cytoplasmic events, such as transcript localization. He then stayed at Duke to pursue his PhD in the laboratory of
1471:
1456:
556:
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300:"Pathways to Independence" award. There, he shifted his research focus to studying the developmental neurobiology of the nematode
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1436:
655:"Inhibition of translation and induction of apoptosis by Bunyaviral nonstructural proteins bearing sequence similarity to reaper"
1066:
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507:
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580:
449:
was launched using
CienciaPR as a model to encourage students from Latino backgrounds at Yale and beyond to study science.
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358:
297:
877:"WormGUIDES: an interactive single cell developmental atlas and tool for collaborative multidimensional data exploration"
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216:(CienciaPR), a collaborative network for people interested in science and Puerto Rico. In 2020, he was named to the
1343:
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377:
350:
266:
237:
143:
405:, and his approach to mentoring the next generation of scientists. The series was presented in partnership with
422:
257:
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438:
935:"Project Information – NIH RePORTER – NIH Research Portfolio Online Reporting Tools Expenditures and Results"
785:"Project Information – NIH RePORTER – NIH Research Portfolio Online Reporting Tools Expenditures and Results"
581:"Project Information – NIH RePORTER – NIH Research Portfolio Online Reporting Tools Expenditures and Results"
446:
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277:. For his doctoral work, Colón-Ramos studied the molecular mechanisms underlying programmed cell death, or
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to power brain functions, which include memory formation and behavior. He holds an appointment at
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249:
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286:
557:"Success Stories: Daniel Colón-Ramos | National Institute of Neurological Disorders and Stroke"
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256:. He then worked as a research assistant, with the support of an NIH Diversity Supplement, in
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In 2006, during his postdoctoral fellowship at
Stanford University, Colón-Ramos founded
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456:, which is tasked with evaluating the effect of pollutants on population health at
121:
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about the role racism and discrimination continues to play in science education.
315:
provide a roadmap for these connections to be made through the signaling molecule
1405:
1103:
376:
and is an adjunct professor at the
Instituto de Neurobiología José del Castillo,
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410:
402:
401:, in which he described his research, his path to science from his childhood in
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240:. He studied elementary school in Colegio Mater Salvatoris and high school in
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1197:"Disease and deception in the Caribbean | Humanitarian crises | Al Jazeera"
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639:
472:. Also in 2013, he and collaborator Guerrero-Medina authored an op-ed for
1067:"Science's "Creativity Crisis"; a New Material That's Blacker Than Black"
1041:"On nature versus nature: A neuroscientist knee-deep in diapers reflects"
364:
In 2018, Colón-Ramos received a "High-Risk, High Reward" grant from the
332:
307:
1148:"2011 Early Career Award for Public Engagement with Science Recipient"
208:
is the McConnell Duberg
Professor of Neuroscience and Cell Biology at
727:
469:
369:
316:
264:. There, he studied how the architecture of the nucleus of the algae
150:
852:"Home > Colón-Ramos Lab | Cell Biology | Yale School of Medicine"
1244:
Colón-Ramos, Daniel; Quinones-Hinojosa, Alfredo (August 4, 2016).
397:-sponsored series called Conversations in Science with journalist
67:
1376:
1016:"Conversations in Science with Daniel Colón-Ramos and Dan Rather"
712:"Direct ribosomal binding by a cellular inhibitor of translation"
1271:"Bell and Colón-Ramos Are Named to National Academy of Medicine"
312:
89:
473:
76:
1087:"Supporting Diversity in Science through Social Networking"
355:
National
Institute of Biomedical Imaging and Bioengineering
962:"NIH Director's Pioneer Award Program – Award Recipients"
1171:
Milstein, Larry; Rogers, Stephanie (February 19, 2015).
536:
Klingenstein
Fellowship Award in the Neurosciences, 2009
1398:"The Esther A. & and Joseph Klingenstein Fund, Inc"
523:
Early Career Award for Public Engagement with Science,
327:
In 2008, Colón-Ramos became an assistant professor at
808:
Hines, Pamela J. (2007-10-09). "Neuronal Road Map".
1152:
American Association for the Advancement of Science
525:
American Association for the Advancement of Science
504:
NINDS Landis Award for Outstanding Mentorship, 2018
443:
American Association for the Advancement of Science
409:, which was founded by Lasker laureate, biochemist
368:to better understand how energy is produced within
193:
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127:
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83:
59:
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37:
21:
1173:"Yale launches minority outreach program in STEM"
454:Agency for Toxic Substances and Disease Registry
393:In November 2018, Colón-Ramos participated in a
254:Smithsonian Tropical Research Institute (STRI)
16:Researcher, Yale University School of Medicine
94:AAAS Early Career Award for Public Engagement
8:
1296:"Colón-Ramos awarded Landis Mentoring Award"
1482:Members of the National Academy of Medicine
345:In collaboration with William A. Mohler at
1221:"We are not starfish | Need to Know | PBS"
413:. He has also spoken on the importance of
29:
18:
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716:Nature Structural & Molecular Biology
686:
621:
296:fellow, with the additional support of a
545:
347:University of Connecticut Health Center
294:Damon Runyon Cancer Research Foundation
1142:
1140:
956:
954:
7:
1447:Colegio San Ignacio de Loyola alumni
1344:"E.E. Just Award—Daniel Colón-Ramos"
767:Colón-Ramos, Daniel Alfonso (2003).
551:
549:
441:. In 2011, Colón-Ramos received the
228:Colón-Ramos was born and raised in
384:Science communication and outreach
329:Yale University School of Medicine
232:, growing up between the towns of
210:Yale University School of Medicine
14:
518:American Society for Cell Biology
508:Howard Hughes Medical Institute
1065:Brown, Lydia (June 12, 2015).
1:
659:Molecular Biology of the Cell
623:10.1016/s1534-5807(03)00163-1
481:, he also wrote an op-ed for
366:National Institutes of Health
359:National Institutes of Health
298:National Institutes of Health
242:Colegio San Ignacio de Loyola
1246:"Racism in the Research Lab"
1104:10.1371/journal.pbio.1001740
496:National Academy of Medicine
374:Marine Biological Laboratory
218:National Academy of Medicine
180:Other academic advisors
140:Marine Biological Laboratory
1498:
224:Education and early career
206:Daniel Alfonso Colón-Ramos
1442:Harvard University alumni
1294:Vaca, Noah (2018-09-05).
894:10.1186/s12859-015-0627-8
822:10.1126/stke.4072007tw365
479:Alfredo Quiñones-Hinojosa
378:University of Puerto Rico
353:, and Hari Shroff at the
351:Sloan Kettering Institute
267:Chlamydomonas reinhardtii
189:
144:University of Puerto Rico
102:
28:
1472:Developmental biologists
1457:American neuroscientists
460:sites like one found in
439:Giovanna Guerrero-Medina
423:Connecticut Public Radio
1467:Yale University faculty
1437:Puerto Rican scientists
1320:"2016 Faculty Scholars"
939:projectreporter.nih.gov
789:projectreporter.nih.gov
671:10.1091/mbc.e03-03-0139
585:projectreporter.nih.gov
501:NIH Pioneer Award, 2018
447:Yale Ciencia Initiative
1452:Duke University alumni
338:Caenorhabditis elegans
303:Caenorhabditis elegans
1462:Science communicators
1324:2016 Faculty Scholars
1020:The Lasker Foundation
531:Sloan Research Fellow
510:Faculty Scholar, 2016
389:Science communication
258:Mariano García-Blanco
118:Developmental biology
97:Sloan Research Fellow
43:Hato Rey, Puerto Rico
23:Daniel A. Colón-Ramos
987:"Daniel Colón-Ramos"
462:Vieques, Puerto Rico
306:. To understand how
435:Ciencia Puerto Rico
429:Ciencia Puerto Rico
214:Ciencia Puerto Rico
132:Stanford University
1250:The New York Times
966:commonfund.nih.gov
881:BMC Bioinformatics
610:Developmental Cell
514:E. E. Just Lecture
483:The New York Times
250:Harvard University
244:. He received his
64:Harvard University
1402:www.klingfund.org
1275:medicine.yale.edu
1201:www.aljazeera.com
1177:yaledailynews.com
1022:. 31 October 2018
856:medicine.yale.edu
665:(10): 4162–4172.
561:www.ninds.nih.gov
489:Awards and honors
395:Lasker Foundation
349:, Zhirong Bao at
260:'s laboratory at
203:
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104:Scientific career
87:NIH Pioneer Award
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494:Elected Member,
421:xSanJuan and on
246:Bachelor of Arts
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169:Doctoral advisor
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262:Duke University
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174:Sally Kornbluth
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136:Yale University
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92:Faculty Scholar
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60:Alma mater
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968:. 26 June 2013
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616:(6): 941–952.
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1410:. Retrieved
1406:the original
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1377:the original
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1350:. 2016-12-04
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313:glial cells
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