684:
After his retirement Dane did not to return the
Middlesex Hospital Medical School. However his legacy of pushing diagnostic development and collaboration with the diagnostic industry continued with Middlesex Hospital Medical School, Virology developing the first UK HIV diagnostic assay, the
563:, coated with antibody to HBsAg agglutinate (clump together) in the presence of HBsAg, a sensitive test which was widely used diagnostically. Not content with that, he and his laboratory colleagues produced in collaboration with Brian Combridge at the
33:
435:
charities in recognition of his work in this field. Very much in character, he developed productive collaborations with senior colleagues within the medical school and hospital. Together with Dr Duncan
Catterall, head of the
146:
631:
in
Britain from freely donated blood, rather than from imported blood from the US where donors were paid. The consequences of not following this advice, and Britainβs failure to be self-sufficient for treatment of
150:
701:
In 1955, Dane married
Veronica (nΓ©e Tester), widow of Maj. Iain Herford Hope (1918β1951); she had two children, Kerin and Alex. They had met in Australia. Together they had three children:
1053:
Fulford, K. W. M.; Dane, D. S.; Catterall, R. D.; Woof, R.; Denning, J. V. (1973). "Australia antigen and antibody among patients attending a clinic for sexually transmitted diseases".
523:. Those who trained with him recall with wry amusement the irritation if he was to hear anyone referring to the 42 nm form by its eponymous title, even if abbreviated to "DP".
348:
work led by John Miles, head of the
Medical Research Division in the early 1950s. Dane continued to work to improve diagnostic methods and published on avian and human psittacosis.
648:
to reserve concentrate use to those whose management absolutely depended on it saved many from HIV infection. He also was early to recognise the occurrence of hepatitis other than
672:β treatment with contaminated blood, and on other matters. He remained resolutely opposed to the trend among research scientists to seek commercial gain from their discoveries by
1183:
Barbara, J. A. J.; Howell, D. R.; Cleghorn, T. E.; Cameron, C. H.; Briggs, M.; Dane, D. S. (1977). "A comparison of different methods of screening blood donations for HBsAg".
1550:
202:. Daneβs interest in developments in transfusion microbiology enabled him to advise on important public health decisions from the 1960s right up until his death in 1998.
543:
at NLBTC which he continued to hold after his retirement in 1982, until his death. Through this association with the blood services Dane went on both to improve current
183:. He is particularly remembered for his strategic foresight in the field of blood transfusion microbiology, particularly in relation to diseases that are spread through
910:
Dane, D. S., Miles, J. A. R., & Stoker, M. G. P. (1953). A disease of Manx
Shearwaters: further observations in the field. The Journal of Animal Acology, 123-133.
1565:
1540:
253:(1956β62), and his wife Dorothy Mary, daughter of Rev. William Alexander Armstrong, M.A. (Cantab.), vicar of West Dean, near Chichester; her brother was the artist
1269:
Cameron, C. H.; Combridge, B. S.; Howell, D. R.; Barbara, J. A. J. (1980). "A sensitive immunoradiometric assay for the detection of hepatitis B surface antigen".
1570:
1545:
500:
post-transfusion hepatitis led to identification of the morphological form of the hepatitis: he characterised the particles in the blood of patients with "
317:
329:
159:
781:
1136:
Dane, D. S.; Cameron, C. H.; Briggs, M. (4 April 1970). "Virus-like particles in serum of patients with
Australia-antigen-associated hepatitis".
1575:
823:
818:
McCue, Paul (2009). SAS Operation
Bulbasket: Behind the Lines in Occupied France. Barnsley, S. Yorks, UK: Pen and Sword Books Ltd. p. 232.
1087:
Doniach, D., Del Prete, S., Dane, D. S., & Walsh, J. H. (1972). "Viral hepatitis related antigens in 'autoimmune' hepatic disorders",
664:
Dane retired in 1982, just before major rates of HIV infection emerged. He continued as an advisor after retirement, including offering
273:
473:
465:
420:
210:
129:
237:
David
Maurice Surrey Dane was the son of William Surrey Dane (1892β1978), C.B.E., M.C., vice-chairman and managerial consultant of
690:
606:
and the role of the persistently infected person as a reservoir of infection in the community, identifying the individual whose
693:. His enduring demand for precision, accuracy and objectivity influenced many in the field of Clinical Virology to this day.
686:
610:
contained large amounts of virus, coining the term "super-carriers". He also described the dynamics of the virus particle in
644:
concentrate. Potentially disastrous for groups such as haemophiliacs, who early on became infected with HIV, his advice to
1560:
365:
229:. Whatever investigations were carried out were expected to be precise, accurate, reproducible and of clinical relevance.
125:
484:
With his colleagues Colin "Sam" Cameron and Moya Briggs he was, in 1970, the first to describe the virus responsible for
1555:
437:
292:
242:
1304:
Lim, K. S.; Catterall, R. D.; Simon, R.; Dane, D. S.; Briggs, M.; Tedder, R. S. (1979). "A reservoir of hepatitis B".
846:
571:
for HBsAg, the BPL RIA. They also developed specialised equipment for its use. His colleague Sam
Cameron produced the
246:
1218:
Barbara, J. A.; Harrison, P. J.; Howell, D. R.; Cleghorn, T. E.; Dane, D. S.; Briggs, M.; Cameron, C. H. (1979).
218:
590:
in donors, investigation and surveillance of post transfusion infections became established routine activities.
296:
265:
90:
564:
254:
213:
were renowned for diagnostic precision irrespective of whether this involved dated technology, for example
300:
94:
668:
advice against the importation of blood from the USA. In the 1990s he advised in legal cases relating to
645:
461:
369:
1382:
Domen, R. E. (1995). "Paid-versus-volunteer blood donation in the United States: a historical review".
778:
1535:
1530:
548:
453:
395:
when excreted by people given the vaccine. Professor Dickβs team also initiated studies of combined
806:"Second Supplement to The London Gazette - War Office, 16th October, 1942" (1942). Retrieved from:
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445:
428:
380:
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226:
172:
80:
1171:
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1442:
1220:"A sensitive single reverse passive haemagglutination test for detecting both HBsAg and anti-HBs"
937:
893:
441:
373:
1461:
1434:
1399:
1364:
1286:
1251:
1200:
1170:
Patlak, M. (2009). The hepatitis B story. Β© 2000 National Academy of Sciences. Retrieved from
1153:
1118:
1070:
1035:
986:
885:
819:
556:
497:
184:
69:
768:
Debrett's Peerage, Baronetage, Knightage and Companionage, 1973, Kelly's Directories, p. 2582
190:
Through his research, Dane was instrumental in developing and producing robust and sensitive
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1391:
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1344:
1313:
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1145:
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568:
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222:
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in the UK blood transfusion services. This greatly reduced the risk of post-transfusion
1359:
1332:
1246:
1219:
1030:
1005:
981:
956:
881:
748:
628:
552:
419:
to become the head of the Virology Department, Bland Sutton School of Pathology at the
384:
269:
195:
1498:
1430:
1395:
1317:
1149:
1066:
1524:
1282:
1114:
797:
John Armstrong: The Paintings, Andrew Lambirth, Philip Wilson Publishing, 2009, p. 13
735:
669:
633:
584:
580:
468:, and Tom Cleghorn, director of the North London Blood Transfusion Centre (NLBTC) at
176:
1485:"Supplement to The London Gazette β Friday, 20th April 1990" (1990). Retrieved from
1446:
941:
897:
607:
493:
361:
238:
531:
Dane's determination to improve the accuracy of detecting the hepatitis B surface
332:. He was instrumental in an extensive investigation of an undiagnosed outbreak of
268:, however, he volunteered instead to join the Army. In 1941, after enlisting as a
702:
653:
649:
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637:
603:
540:
520:
505:
485:
457:
345:
164:
1021:
587:
576:
396:
337:
333:
168:
1417:
Dane, D. S.; Cameron, C. H. (1975). "Factor-VIII Concentrate and Hepatitis".
1333:"Role of sexual and non-sexual practices in the transmission of hepatitis B"
972:
673:
572:
516:
509:
449:
400:
392:
199:
111:
1331:
Lim, KS; Wong, VT; Fulford, KW; Catterall, RD; Briggs, M; Dane, DS (1977).
1236:
990:
933:
889:
730:
539:, and his keen interest in blood transfusion led him to accept an honorary
1403:
1290:
1157:
1122:
1074:
1039:
1368:
1349:
1255:
1204:
665:
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357:
341:
321:
249:
newspaper (1949β60), and a member of the General Advisory Council of the
206:
191:
180:
115:
1438:
32:
532:
469:
427:. At that time this was one of the very few medical schools to have an
416:
404:
156:
153:
1196:
627:
Dane was a strong advocate of self sufficiency for the manufacture of
544:
424:
281:
1101:
Purcell, RH (April 1993). "The discovery of the hepatitis viruses".
779:
http://oxfordindex.oup.com/view/10.1093/ww/9780199540884.013.U153703
536:
432:
1006:"Further studies with a diphtheria-tetanus-poliomyelitis vaccine"
1172:
http://www.margiepatlak.com/files/quicksiteimages/hepatitis.pdf
808:
https://www.thegazette.co.uk/London/issue/35746/supplement/4486
383:. Through their research they established that the early live
325:
250:
241:
and chairman/ president of several hospital boards, including
179:
and the early investigations into the efficacy of a number of
1004:
Haire, M; Dane, DS; Dick, G; Briggs, EM; Connor, TJ (1966).
957:"Vaccination Against Poliomyelitis with Live Virus Vaccines"
656:
following treatment with the anti-haemophiliac concentrate.
336:
and isolated a potential cause. It was inevitable that as a
205:
During the later part of his professional career he and his
920:
Dick, GWA; Dane, DS (1959). "Live Poliomyelitis Vaccine".
868:
Miles, J. A. R. (1954). "Benign lymphocytic meningitis".
456:. Close collaborations with two senior colleagues in the
163:(25 March 1923 β 9 April 1998) was a pre-eminent British
575:
label and with John Barabara of NLBTC, merged this with
272:, Dane was selected for officer training. He joined the
1487:
https://www.thegazette.co.uk/London/issue/52116/page/1
476:
and particularly that of post-transfusion hepatitis.
472:
led to ground-breaking work in the emerging field of
299:
and later undertook his clinical medical training at
356:
On returning to the UK, in 1955, Dane was appointed
1462:"Left to die: the hidden victims of an NHS blunder"
121:
107:
86:
76:
58:
39:
23:
955:Dane, DS; Dick, GWA; Briggs, M; Nelson, R (1958).
618:Implications of HIV for blood transfusion practice
551:methods. A close collaboration with Ian Cayzer in
444:, Dane quickly demonstrated the usefulness of the
705:, Penelope and Thomas. Dane died in April 1998.
777:Who was Who entry, published online 2007 URL=
8:
318:Institute of Medical and Veterinary Science
221:, or state-of-the-art technology including
16:British pathologist and clinical virologist
31:
20:
1358:
1348:
1245:
1235:
1029:
980:
391:were unsafe because they could return to
724:
722:
720:
718:
466:Middlesex Hospital Medical School (MHMS)
1551:Academics of Queen's University Belfast
836:
834:
832:
731:"Obituary: David Surrey Dane 1923β1998"
714:
280:. In July 1944, he was parachuted into
1566:British Army personnel of World War II
1541:People educated at Charterhouse School
685:Wellcozyme HIV test which led to the
340:he would also become involved in the
7:
1337:British Journal of Venereal Diseases
1089:Canadian Medical Association Journal
559:assay for HBsAg, "Hepatest". Turkey
454:herpes simplex virus infection (HSV)
324:, in 1951 supported by a grant from
1571:British Parachute Regiment officers
1499:"Military funeral for R.A. Officer"
583:. Methods for selecting high-titre
276:in 1943, and then the newly formed
1546:Alumni of Clare College, Cambridge
882:10.5694/j.1326-5377.1954.tb85712.x
749:10.1046/j.1423-0410.1998.7530177.x
691:Queen's Award for British Industry
464:, Professor of Haematology at the
14:
474:transfusion transmitted infection
440:clinic in James Pringle House at
421:Middlesex Hospital Medical School
211:Middlesex Hospital Medical School
171:known for his pioneering work in
130:Middlesex Hospital Medical School
1460:Martin, Lorna (16 April 2016).
640:of the then "new" treatment of
496:from donors implicated in long
219:complement fixation tests (CFT)
1271:Journal of Virological Methods
687:Wellcome Research Laboratories
646:James Wallace "Jimmie" Stewart
547:and to develop more sensitive
480:The Hepatitis B Virus Particle
462:James Wallace "Jimmie" Stewart
291:He returned to the UK to read
1:
1431:10.1016/s0140-6736(75)92769-5
1396:10.1016/s0887-7963(05)80030-6
1318:10.1016/s0163-4453(79)80009-2
1224:Journal of Clinical Pathology
1150:10.1016/s0140-6736(70)90926-8
1067:10.1016/s0140-6736(73)91810-2
1576:Special Air Service officers
1384:Transfusion Medicine Reviews
1283:10.1016/0166-0934(80)90048-8
1115:10.1016/0016-5085(93)90261-a
870:Medical Journal of Australia
579:technology and multichannel
438:sexually transmitted disease
243:Great Ormond Street Hospital
847:Royal College of Physicians
842:"David Maurice Surrey Dane"
788:Date accessed= 14 Sep. 2018
729:Barbara, John A.J. (1998).
245:(1957β67), chairman of the
1592:
1505:. 4 August 1951. p. 3
594:Sexual transmission of HBV
372:on the recently developed
366:Queen's University Belfast
126:Queen's University Belfast
1503:The Advertiser (Adelaide)
1022:10.1017/s0022172400040791
784:14 September 2018 at the
636:made the UK reliant upon
623:Blood product manufacture
565:Blood Products Laboratory
278:Special Air Service (SAS)
142:David Maurice Surrey Dane
135:
100:
44:David Maurice Surrey Dane
30:
1091:, 106 (Spec Issue), 513.
527:Transfusion microbiology
490:electron microscopy (EM)
330:Medical Research Council
297:Clare College, Cambridge
266:Clare College, Cambridge
227:electron microscopy (EM)
91:Clare College, Cambridge
973:10.1136/bmj.2.5106.1187
961:British Medical Journal
922:British Medical Journal
368:, where he worked with
1237:10.1136/jcp.32.11.1180
1010:The Journal of Hygiene
934:10.1136/bmj.1.5125.853
223:radioimmunoassay (RIA)
207:Department of Virology
508:was then known. This
488:. His application of
370:Professor George Dick
264:. He was admitted to
194:for the screening of
1561:British pathologists
1350:10.1136/sti.53.3.190
1306:Journal of Infection
553:Wellcome Diagnostics
342:avian/human zoonosis
215:immunodiffusion (ID)
1556:British virologists
1061:(7818): 1470β1473.
967:(5106): 1187β1188.
600:sexual transmission
567:the first UK-based
446:electron microscope
429:electron microscope
415:In 1966, Dane left
381:poliovirus vaccines
301:St Thomas' Hospital
286:Operation Bulbasket
262:Charterhouse School
173:infectious diseases
169:clinical virologist
95:St Thomas' Hospital
81:Charterhouse School
442:Middlesex Hospital
274:Parachute Regiment
1425:(7929): 328β329.
1230:(11): 1180β1183.
1197:10.1159/000467404
1144:(7649): 695β698.
928:(5125): 853β854.
824:978-1-84884-193-2
557:haemagglutination
486:hepatitis B (HBV)
312:Move to Australia
185:blood transfusion
162:
139:
138:
102:Scientific career
70:Puttenham, Surrey
1583:
1515:
1514:
1512:
1510:
1495:
1489:
1483:
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1476:
1474:
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1457:
1451:
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1414:
1408:
1407:
1379:
1373:
1372:
1362:
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1328:
1322:
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1301:
1295:
1294:
1266:
1260:
1259:
1249:
1239:
1215:
1209:
1208:
1180:
1174:
1168:
1162:
1161:
1133:
1127:
1126:
1103:Gastroenterology
1098:
1092:
1085:
1079:
1078:
1050:
1044:
1043:
1033:
1001:
995:
994:
984:
952:
946:
945:
917:
911:
908:
902:
901:
865:
859:
858:
856:
854:
838:
827:
816:
810:
804:
798:
795:
789:
775:
769:
766:
760:
759:
757:
755:
726:
598:Dane identified
389:Hilary Koprowski
352:Return to the UK
338:field virologist
334:acute meningitis
316:Dane joined the
293:Natural Sciences
145:
65:
53:
51:
35:
21:
1591:
1590:
1586:
1585:
1584:
1582:
1581:
1580:
1521:
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1497:
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1376:
1330:
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1302:
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1212:
1182:
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1169:
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1135:
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1095:
1086:
1082:
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954:
953:
949:
919:
918:
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909:
905:
867:
866:
862:
852:
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839:
830:
817:
813:
805:
801:
796:
792:
786:Wayback Machine
776:
772:
767:
763:
753:
751:
728:
727:
716:
711:
699:
682:
662:
625:
620:
612:acute infection
596:
561:red blood cells
529:
502:serum hepatitis
482:
413:
354:
326:National Health
314:
309:
235:
128:
114:
93:
87:Alma mater
72:
67:
63:
49:
47:
46:
45:
26:
17:
12:
11:
5:
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1523:
1522:
1517:
1516:
1490:
1478:
1452:
1409:
1374:
1343:(3): 190β192.
1323:
1312:(2): 163β170.
1296:
1277:(6): 311β323.
1261:
1210:
1175:
1163:
1128:
1093:
1080:
1045:
1016:(4): 485β488.
996:
947:
912:
903:
876:(18): 659β64.
860:
828:
811:
799:
790:
770:
761:
713:
712:
710:
707:
698:
695:
689:receiving the
681:
678:
661:
660:Expert witness
658:
629:blood products
624:
621:
619:
616:
595:
592:
581:gamma counters
528:
525:
481:
478:
448:for the rapid
412:
409:
385:polio vaccines
353:
350:
313:
310:
308:
305:
260:Dane attended
255:John Armstrong
234:
231:
149:CRCP MB Bchir
137:
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133:
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123:
119:
118:
109:
105:
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68:
66:(aged 75)
60:
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37:
36:
28:
27:
24:
15:
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1229:
1225:
1221:
1214:
1211:
1206:
1202:
1198:
1194:
1190:
1186:
1185:Vox Sanguinis
1179:
1176:
1173:
1167:
1164:
1159:
1155:
1151:
1147:
1143:
1139:
1132:
1129:
1124:
1120:
1116:
1112:
1109:(4): 955β63.
1108:
1104:
1097:
1094:
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1084:
1081:
1076:
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1037:
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1027:
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983:
978:
974:
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966:
962:
958:
951:
948:
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931:
927:
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871:
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861:
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843:
837:
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791:
787:
783:
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771:
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762:
750:
746:
742:
738:
737:
736:Vox Sanguinis
732:
725:
723:
721:
719:
715:
708:
706:
704:
697:Personal life
696:
694:
692:
688:
679:
677:
675:
671:
670:haemophiliacs
667:
659:
657:
655:
651:
647:
643:
639:
635:
634:haemophiliacs
630:
622:
617:
615:
613:
609:
605:
601:
593:
591:
589:
586:
585:antimicrobial
582:
578:
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1509:14 September
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1466:The Guardian
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239:Odhams Press
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196:blood donors
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122:Institutions
101:
64:(1998-04-09)
62:9 April 1998
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1536:1998 deaths
1531:1923 births
650:hepatitis A
642:factor VIII
638:importation
604:hepatitis B
541:consultancy
517:eponymously
506:hepatitis B
492:to examine
458:haematology
346:psittacosis
284:as part of
165:pathologist
1525:Categories
1419:The Lancet
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1138:The Lancet
1055:The Lancet
709:References
680:His legacy
588:antibodies
577:microplate
498:incubation
407:vaccines.
397:diphtheria
303:, London.
233:Early life
175:including
50:1923-03-25
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674:patenting
573:iodinated
549:screening
535:protein,
450:diagnosis
401:pertussis
393:virulence
374:attenuate
200:hepatitis
112:Pathology
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666:pro bono
513:particle
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322:Adelaide
192:reagents
181:vaccines
116:Virology
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411:London
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282:France
108:Fields
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938:S2CID
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537:HBsAg
510:42 nm
433:Polio
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1473:2019
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855:2016
820:ISBN
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