Knowledge (XXG)

David Dane

Source πŸ“

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After his retirement Dane did not to return the Middlesex Hospital Medical School. However his legacy of pushing diagnostic development and collaboration with the diagnostic industry continued with Middlesex Hospital Medical School, Virology developing the first UK HIV diagnostic assay, the
563:, coated with antibody to HBsAg agglutinate (clump together) in the presence of HBsAg, a sensitive test which was widely used diagnostically. Not content with that, he and his laboratory colleagues produced in collaboration with Brian Combridge at the 33: 435:
charities in recognition of his work in this field. Very much in character, he developed productive collaborations with senior colleagues within the medical school and hospital. Together with Dr Duncan Catterall, head of the
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in Britain from freely donated blood, rather than from imported blood from the US where donors were paid. The consequences of not following this advice, and Britain’s failure to be self-sufficient for treatment of
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In 1955, Dane married Veronica (nΓ©e Tester), widow of Maj. Iain Herford Hope (1918–1951); she had two children, Kerin and Alex. They had met in Australia. Together they had three children:
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Fulford, K. W. M.; Dane, D. S.; Catterall, R. D.; Woof, R.; Denning, J. V. (1973). "Australia antigen and antibody among patients attending a clinic for sexually transmitted diseases".
523:. Those who trained with him recall with wry amusement the irritation if he was to hear anyone referring to the 42 nm form by its eponymous title, even if abbreviated to "DP". 348:
work led by John Miles, head of the Medical Research Division in the early 1950s. Dane continued to work to improve diagnostic methods and published on avian and human psittacosis.
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to reserve concentrate use to those whose management absolutely depended on it saved many from HIV infection. He also was early to recognise the occurrence of hepatitis other than
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Barbara, J. A. J.; Howell, D. R.; Cleghorn, T. E.; Cameron, C. H.; Briggs, M.; Dane, D. S. (1977). "A comparison of different methods of screening blood donations for HBsAg".
1550: 202:. Dane’s interest in developments in transfusion microbiology enabled him to advise on important public health decisions from the 1960s right up until his death in 1998. 543:
at NLBTC which he continued to hold after his retirement in 1982, until his death. Through this association with the blood services Dane went on both to improve current
183:. He is particularly remembered for his strategic foresight in the field of blood transfusion microbiology, particularly in relation to diseases that are spread through 910:
Dane, D. S., Miles, J. A. R., & Stoker, M. G. P. (1953). A disease of Manx Shearwaters: further observations in the field. The Journal of Animal Acology, 123-133.
1565: 1540: 253:(1956–62), and his wife Dorothy Mary, daughter of Rev. William Alexander Armstrong, M.A. (Cantab.), vicar of West Dean, near Chichester; her brother was the artist 1269:
Cameron, C. H.; Combridge, B. S.; Howell, D. R.; Barbara, J. A. J. (1980). "A sensitive immunoradiometric assay for the detection of hepatitis B surface antigen".
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post-transfusion hepatitis led to identification of the morphological form of the hepatitis: he characterised the particles in the blood of patients with "
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Dane, D. S.; Cameron, C. H.; Briggs, M. (4 April 1970). "Virus-like particles in serum of patients with Australia-antigen-associated hepatitis".
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McCue, Paul (2009). SAS Operation Bulbasket: Behind the Lines in Occupied France. Barnsley, S. Yorks, UK: Pen and Sword Books Ltd. p. 232.
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Doniach, D., Del Prete, S., Dane, D. S., & Walsh, J. H. (1972). "Viral hepatitis related antigens in 'autoimmune' hepatic disorders",
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Dane retired in 1982, just before major rates of HIV infection emerged. He continued as an advisor after retirement, including offering
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David Maurice Surrey Dane was the son of William Surrey Dane (1892–1978), C.B.E., M.C., vice-chairman and managerial consultant of
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and the role of the persistently infected person as a reservoir of infection in the community, identifying the individual whose
693:. His enduring demand for precision, accuracy and objectivity influenced many in the field of Clinical Virology to this day. 686: 610:
contained large amounts of virus, coining the term "super-carriers". He also described the dynamics of the virus particle in
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concentrate. Potentially disastrous for groups such as haemophiliacs, who early on became infected with HIV, his advice to
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With his colleagues Colin "Sam" Cameron and Moya Briggs he was, in 1970, the first to describe the virus responsible for
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Lim, K. S.; Catterall, R. D.; Simon, R.; Dane, D. S.; Briggs, M.; Tedder, R. S. (1979). "A reservoir of hepatitis B".
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for HBsAg, the BPL RIA. They also developed specialised equipment for its use. His colleague Sam Cameron produced the
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Barbara, J. A.; Harrison, P. J.; Howell, D. R.; Cleghorn, T. E.; Dane, D. S.; Briggs, M.; Cameron, C. H. (1979).
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in donors, investigation and surveillance of post transfusion infections became established routine activities.
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were renowned for diagnostic precision irrespective of whether this involved dated technology, for example
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advice against the importation of blood from the USA. In the 1990s he advised in legal cases relating to
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Domen, R. E. (1995). "Paid-versus-volunteer blood donation in the United States: a historical review".
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when excreted by people given the vaccine. Professor Dick’s team also initiated studies of combined
806:"Second Supplement to The London Gazette - War Office, 16th October, 1942" (1942). Retrieved from: 599: 489: 445: 428: 380: 377: 285: 277: 261: 226: 172: 80: 1171: 807: 1442: 1220:"A sensitive single reverse passive haemagglutination test for detecting both HBsAg and anti-HBs" 937: 893: 441: 373: 1461: 1434: 1399: 1364: 1286: 1251: 1200: 1170:
Patlak, M. (2009). The hepatitis B story. Β© 2000 National Academy of Sciences. Retrieved from
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Debrett's Peerage, Baronetage, Knightage and Companionage, 1973, Kelly's Directories, p. 2582
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Through his research, Dane was instrumental in developing and producing robust and sensitive
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in the UK blood transfusion services. This greatly reduced the risk of post-transfusion
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to become the head of the Virology Department, Bland Sutton School of Pathology at the
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John Armstrong: The Paintings, Andrew Lambirth, Philip Wilson Publishing, 2009, p. 13
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Dane's determination to improve the accuracy of detecting the hepatitis B surface
332:. He was instrumental in an extensive investigation of an undiagnosed outbreak of 268:, however, he volunteered instead to join the Army. In 1941, after enlisting as a 702: 653: 649: 641: 637: 603: 540: 520: 505: 485: 457: 345: 164: 1021: 587: 576: 396: 337: 333: 168: 1417:
Dane, D. S.; Cameron, C. H. (1975). "Factor-VIII Concentrate and Hepatitis".
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Lim, KS; Wong, VT; Fulford, KW; Catterall, RD; Briggs, M; Dane, DS (1977).
1236: 990: 933: 889: 730: 539:, and his keen interest in blood transfusion led him to accept an honorary 1403: 1290: 1157: 1122: 1074: 1039: 1368: 1349: 1255: 1204: 665: 512: 357: 341: 321: 249:
newspaper (1949–60), and a member of the General Advisory Council of the
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Dane was a strong advocate of self sufficiency for the manufacture of
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Purcell, RH (April 1993). "The discovery of the hepatitis viruses".
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http://oxfordindex.oup.com/view/10.1093/ww/9780199540884.013.U153703
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http://www.margiepatlak.com/files/quicksiteimages/hepatitis.pdf
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https://www.thegazette.co.uk/London/issue/35746/supplement/4486
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and chairman/ president of several hospital boards, including
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and the early investigations into the efficacy of a number of
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Haire, M; Dane, DS; Dick, G; Briggs, EM; Connor, TJ (1966).
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following treatment with the anti-haemophiliac concentrate.
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and isolated a potential cause. It was inevitable that as a
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During the later part of his professional career he and his
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Dick, GWA; Dane, DS (1959). "Live Poliomyelitis Vaccine".
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Miles, J. A. R. (1954). "Benign lymphocytic meningitis".
456:. Close collaborations with two senior colleagues in the 163:(25 March 1923 – 9 April 1998) was a pre-eminent British 575:
label and with John Barabara of NLBTC, merged this with
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https://www.thegazette.co.uk/London/issue/52116/page/1
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and particularly that of post-transfusion hepatitis.
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led to ground-breaking work in the emerging field of
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and later undertook his clinical medical training at
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On returning to the UK, in 1955, Dane was appointed
1462:"Left to die: the hidden victims of an NHS blunder" 121: 107: 86: 76: 58: 39: 23: 955:Dane, DS; Dick, GWA; Briggs, M; Nelson, R (1958). 618:Implications of HIV for blood transfusion practice 551:methods. A close collaboration with Ian Cayzer in 444:, Dane quickly demonstrated the usefulness of the 705:, Penelope and Thomas. Dane died in April 1998. 777:Who was Who entry, published online 2007 URL= 8: 318:Institute of Medical and Veterinary Science 221:, or state-of-the-art technology including 16:British pathologist and clinical virologist 31: 20: 1358: 1348: 1245: 1235: 1029: 980: 391:were unsafe because they could return to 724: 722: 720: 718: 466:Middlesex Hospital Medical School (MHMS) 1551:Academics of Queen's University Belfast 836: 834: 832: 731:"Obituary: David Surrey Dane 1923–1998" 714: 280:. In July 1944, he was parachuted into 1566:British Army personnel of World War II 1541:People educated at Charterhouse School 685:Wellcozyme HIV test which led to the 340:he would also become involved in the 7: 1337:British Journal of Venereal Diseases 1089:Canadian Medical Association Journal 559:assay for HBsAg, "Hepatest". Turkey 454:herpes simplex virus infection (HSV) 324:, in 1951 supported by a grant from 1571:British Parachute Regiment officers 1499:"Military funeral for R.A. Officer" 583:. Methods for selecting high-titre 276:in 1943, and then the newly formed 1546:Alumni of Clare College, Cambridge 882:10.5694/j.1326-5377.1954.tb85712.x 749:10.1046/j.1423-0410.1998.7530177.x 691:Queen's Award for British Industry 464:, Professor of Haematology at the 14: 474:transfusion transmitted infection 440:clinic in James Pringle House at 421:Middlesex Hospital Medical School 211:Middlesex Hospital Medical School 171:known for his pioneering work in 130:Middlesex Hospital Medical School 1460:Martin, Lorna (16 April 2016). 640:of the then "new" treatment of 496:from donors implicated in long 219:complement fixation tests (CFT) 1271:Journal of Virological Methods 687:Wellcome Research Laboratories 646:James Wallace "Jimmie" Stewart 547:and to develop more sensitive 480:The Hepatitis B Virus Particle 462:James Wallace "Jimmie" Stewart 291:He returned to the UK to read 1: 1431:10.1016/s0140-6736(75)92769-5 1396:10.1016/s0887-7963(05)80030-6 1318:10.1016/s0163-4453(79)80009-2 1224:Journal of Clinical Pathology 1150:10.1016/s0140-6736(70)90926-8 1067:10.1016/s0140-6736(73)91810-2 1576:Special Air Service officers 1384:Transfusion Medicine Reviews 1283:10.1016/0166-0934(80)90048-8 1115:10.1016/0016-5085(93)90261-a 870:Medical Journal of Australia 579:technology and multichannel 438:sexually transmitted disease 243:Great Ormond Street Hospital 847:Royal College of Physicians 842:"David Maurice Surrey Dane" 788:Date accessed= 14 Sep. 2018 729:Barbara, John A.J. (1998). 245:(1957–67), chairman of the 1592: 1505:. 4 August 1951. p. 3 594:Sexual transmission of HBV 372:on the recently developed 366:Queen's University Belfast 126:Queen's University Belfast 1503:The Advertiser (Adelaide) 1022:10.1017/s0022172400040791 784:14 September 2018 at the 636:made the UK reliant upon 623:Blood product manufacture 565:Blood Products Laboratory 278:Special Air Service (SAS) 142:David Maurice Surrey Dane 135: 100: 44:David Maurice Surrey Dane 30: 1091:, 106 (Spec Issue), 513. 527:Transfusion microbiology 490:electron microscopy (EM) 330:Medical Research Council 297:Clare College, Cambridge 266:Clare College, Cambridge 227:electron microscopy (EM) 91:Clare College, Cambridge 973:10.1136/bmj.2.5106.1187 961:British Medical Journal 922:British Medical Journal 368:, where he worked with 1237:10.1136/jcp.32.11.1180 1010:The Journal of Hygiene 934:10.1136/bmj.1.5125.853 223:radioimmunoassay (RIA) 207:Department of Virology 508:was then known. This 488:. His application of 370:Professor George Dick 264:. He was admitted to 194:for the screening of 1561:British pathologists 1350:10.1136/sti.53.3.190 1306:Journal of Infection 553:Wellcome Diagnostics 342:avian/human zoonosis 215:immunodiffusion (ID) 1556:British virologists 1061:(7818): 1470–1473. 967:(5106): 1187–1188. 600:sexual transmission 567:the first UK-based 446:electron microscope 429:electron microscope 415:In 1966, Dane left 381:poliovirus vaccines 301:St Thomas' Hospital 286:Operation Bulbasket 262:Charterhouse School 173:infectious diseases 169:clinical virologist 95:St Thomas' Hospital 81:Charterhouse School 442:Middlesex Hospital 274:Parachute Regiment 1425:(7929): 328–329. 1230:(11): 1180–1183. 1197:10.1159/000467404 1144:(7649): 695–698. 928:(5125): 853–854. 824:978-1-84884-193-2 557:haemagglutination 486:hepatitis B (HBV) 312:Move to Australia 185:blood transfusion 162: 139: 138: 102:Scientific career 70:Puttenham, Surrey 1583: 1515: 1514: 1512: 1510: 1495: 1489: 1483: 1477: 1476: 1474: 1472: 1457: 1451: 1450: 1414: 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MB Bchir 137: 136: 133: 132: 123: 119: 118: 109: 105: 104: 98: 97: 88: 84: 83: 78: 74: 73: 68: 66:(aged 75) 60: 56: 55: 43: 41: 37: 36: 28: 27: 24: 15: 13: 10: 9: 6: 4: 3: 2: 1588: 1577: 1574: 1572: 1569: 1567: 1564: 1562: 1559: 1557: 1554: 1552: 1549: 1547: 1544: 1542: 1539: 1537: 1534: 1532: 1529: 1528: 1526: 1504: 1500: 1494: 1491: 1488: 1482: 1479: 1467: 1463: 1456: 1453: 1448: 1444: 1440: 1436: 1432: 1428: 1424: 1420: 1413: 1410: 1405: 1401: 1397: 1393: 1389: 1385: 1378: 1375: 1370: 1366: 1361: 1356: 1351: 1346: 1342: 1338: 1334: 1327: 1324: 1319: 1315: 1311: 1307: 1300: 1297: 1292: 1288: 1284: 1280: 1276: 1272: 1265: 1262: 1257: 1253: 1248: 1243: 1238: 1233: 1229: 1225: 1221: 1214: 1211: 1206: 1202: 1198: 1194: 1190: 1186: 1185:Vox Sanguinis 1179: 1176: 1173: 1167: 1164: 1159: 1155: 1151: 1147: 1143: 1139: 1132: 1129: 1124: 1120: 1116: 1112: 1109:(4): 955–63. 1108: 1104: 1097: 1094: 1090: 1084: 1081: 1076: 1072: 1068: 1064: 1060: 1056: 1049: 1046: 1041: 1037: 1032: 1027: 1023: 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Retrieved 740: 734: 700: 683: 663: 626: 597: 530: 483: 414: 362:microbiology 355: 315: 290: 259: 247:Daily Herald 239:Odhams Press 236: 204: 196:blood donors 189: 141: 140: 122:Institutions 101: 64:(1998-04-09) 62:9 April 1998 18: 1536:1998 deaths 1531:1923 births 650:hepatitis A 642:factor VIII 638:importation 604:hepatitis B 541:consultancy 517:eponymously 506:hepatitis B 492:to examine 458:haematology 346:psittacosis 284:as part of 165:pathologist 1525:Categories 1419:The Lancet 1191:(1): 4–9. 1138:The Lancet 1055:The Lancet 709:References 680:His legacy 588:antibodies 577:microplate 498:incubation 407:vaccines. 397:diphtheria 303:, London. 233:Early life 175:including 50:1923-03-25 25:David Dane 674:patenting 573:iodinated 549:screening 535:protein, 450:diagnosis 401:pertussis 393:virulence 374:attenuate 200:hepatitis 112:Pathology 77:Education 1447:54238230 991:13584893 942:41758522 898:42301490 890:13164668 782:Archived 666:pro bono 513:particle 358:lecturer 328:and the 322:Adelaide 192:reagents 181:vaccines 116:Virology 1471:22 June 1404:7719038 1360:1045389 1291:7228972 1247:1145921 1158:4190997 1123:8385046 1075:4123139 1040:5224766 1031:2134759 982:2027199 743:: 177. 602:of the 533:antigen 519:as the 470:Edgware 460:field, 417:Belfast 405:tetanus 270:private 209:at the 157:FRCPath 154:MRCPath 1445:  1437:  1402:  1369:871896 1367:  1357:  1289:  1256:512031 1254:  1244:  1205:841961 1203:  1156:  1121:  1073:  1038:  1028:  989:  979:  940:  896:  888:  822:  754:25 May 703:Roland 676:them. 608:plasma 545:assays 504:", as 494:plasma 425:London 411:London 378:killed 307:Career 282:France 108:Fields 1443:S2CID 1439:50542 938:S2CID 894:S2CID 537:HBsAg 510:42 nm 433:Polio 1511:2018 1473:2019 1435:PMID 1400:PMID 1365:PMID 1287:PMID 1252:PMID 1201:PMID 1154:PMID 1119:PMID 1071:PMID 1036:PMID 987:PMID 886:PMID 855:2016 820:ISBN 756:2022 652:and 376:and 225:and 167:and 160:FRCP 151:MRCP 147:MRCS 59:Died 40:Born 1427:doi 1423:306 1392:doi 1355:PMC 1345:doi 1314:doi 1279:doi 1242:PMC 1232:doi 1193:doi 1146:doi 1111:doi 1107:104 1063:doi 1059:301 1026:PMC 1018:doi 977:PMC 969:doi 930:doi 878:doi 745:doi 569:RIA 452:of 364:at 360:in 344:of 295:at 251:BBC 217:or 1527:: 1501:. 1464:. 1441:. 1433:. 1421:. 1398:. 1386:. 1363:. 1353:. 1341:53 1339:. 1335:. 1308:. 1285:. 1273:. 1250:. 1240:. 1228:32 1226:. 1222:. 1199:. 1189:32 1187:. 1152:. 1140:. 1117:. 1105:. 1069:. 1057:. 1034:. 1024:. 1014:64 1012:. 1008:. 985:. 975:. 963:. 959:. 936:. 924:. 892:. 884:. 872:. 844:. 831:^ 741:75 739:. 733:. 717:^ 614:. 423:, 320:, 288:. 257:. 187:. 144:, 1513:. 1475:. 1449:. 1429:: 1406:. 1394:: 1388:9 1371:. 1347:: 1320:. 1316:: 1310:1 1293:. 1281:: 1275:1 1258:. 1234:: 1207:. 1195:: 1160:. 1148:: 1142:1 1125:. 1113:: 1077:. 1065:: 1042:. 1020:: 993:. 971:: 965:2 944:. 932:: 926:1 900:. 880:: 874:1 857:. 826:. 758:. 747:: 654:B 403:/ 399:/ 52:) 48:(

Index


Puttenham, Surrey
Charterhouse School
Clare College, Cambridge
St Thomas' Hospital
Pathology
Virology
Queen's University Belfast
Middlesex Hospital Medical School
MRCS
MRCP
MRCPath
FRCPath
FRCP
pathologist
clinical virologist
infectious diseases
poliomyelitis
vaccines
blood transfusion
reagents
blood donors
hepatitis
Department of Virology
Middlesex Hospital Medical School
immunodiffusion (ID)
complement fixation tests (CFT)
radioimmunoassay (RIA)
electron microscopy (EM)
Odhams Press

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