236:
as a means to understand the principles of metabolic regulation. Before the development of metabolic control analysis, understanding metabolism was based on qualitative arguments which resulted in some incorrect conclusions (rate-limiting steps). Much of Fell's research for the next 20 years focussed
232:. Given that his early work had a significant mathematical and computational component, he was ideally positioned to consider a more quantitative approach to studying the properties of cellular networks. It was against this background that he turned to the relatively new field called
241:. In 1986 he published with his graduate student Rankin Small, one of the earliest flux-balance models where they used linear programming to examine the efficiency in the conversion of glucose into fat. He was also one of the first researchers to use the
194:. He obtained a position at Oxford Polytechnic as a lecturer. His early work at Oxford Polytechnic focussed on haemoglobin where he developed more precise techniques for monitoring oxygen saturation and the breakdown of
245:
for stochastic simulation in cellular biology, a method that is now routinely used in systems biology. In the late 1990s his research started shifting more towards stoichiometric analysis with particular emphasis on
250:
and the analysis of larger networks such as those involved in photosynthesis and whole genome scale models in a variety of organisms including one of the first genome scale models of
262:
Other than his textbook, which has been cited 1464 times (Sept, 2018), his top ten publications include: two publications related to the evolutionary age of metabolism using
1013:
1008:
712:
Moniz-Barreto, P.; Fell, D. A. (1996), "Simulation of
Dioxygen Free Radical Reactions: Their Importance in the Initiation of Lipid Peroxidation",
744:
Schuster, S.; Hilgetag, C.; Schuster, R. (1996), "Determining
Elementary Modes of Functioning in Biochemical Reaction Networks at Steady State",
224:
and was one of the earliest systems biologists in the UK, with publications from 1979 onwards. The other notable systems biologist at time was
563:
cyclic nucleotide phosphodiesterases in the regulation of the concentration of adenosine 3ā²,5ā²-cyclic monophosphate in animal cells".
761:
729:
371:
988:
237:
on extending and applying metabolic control analysis to metabolism. This work culminated in the publication of his textbook,
210:
1003:
983:
267:
247:
195:
85:
275:
233:
81:
175:
124:
886:
608:"Metabolic control and its analysis: additional relationships between elasticities and control coefficients"
330:
229:
22:
286:
in EGF signalling, and well as the earliest paper that describes the whole genome-scale model of the plant
998:
202:. At this time he also worked on the first modelling studies related to the functioning of high- and low-
279:
89:
993:
452:
Fell, David (1978). "An automated mixing apparatus for determining haemoglobin-oxygen dissociation".
71:
263:
242:
477:
312:
928:
868:
850:
807:
799:
757:
725:
694:
676:
637:
629:
588:
580:
538:
520:
469:
434:
416:
377:
367:
270:, three reviews on metabolic control analysis including a republication of the seminal work,
920:
858:
842:
789:
749:
717:
684:
668:
619:
572:
528:
512:
461:
424:
408:
283:
159:
144:
221:
191:
149:
110:
106:
863:
826:
689:
656:
624:
607:
533:
496:
429:
396:
360:
26:
576:
977:
794:
777:
556:
Fell, David A. (1980). "Theoretical analyses of the functioning of the high- and low-
481:
225:
465:
778:"Elementary modes analysis of photosynthate metabolism in the chloroplast stroma"
721:
753:
395:
Fell, David A.; Liddle, Peter F.; Peacocke, Arthur R.; Dwek, Raymond A. (1974).
288:
657:"Fat synthesis in adipose tissue. An examination of stoichiometric constraints"
199:
854:
803:
680:
633:
584:
524:
420:
381:
872:
811:
932:
846:
698:
641:
592:
438:
542:
114:
473:
924:
672:
516:
412:
968:
131:
825:
Poolman, M. G.; Miguet, L.; Sweetlove, L. J.; Fell, D. A. (2009).
178:. He has published over 200 publications, including a textbook on
776:
Poolman, Mark G.; Fell, David A.; Raines, Christine A. (2003).
911:
Kacser, H; Burns, JA; Fell, DA (1995). "The control of flux".
397:"The preparation and properties of pyruvate kinase from yeast"
174:
is a
British biochemist and professor of systems biology at
495:
El-Yassin, D I; Fell, D A; Lloyd, B B; Fisher, R B (1979).
209:
cyclic nucleotide phosphodiesterases on the regulation of
220:
From the early 1980s David Fell switched his research to
282:, one of the earliest papers that describes a model the
190:
Fell did research on the physical biochemistry of yeast
946:
Kacser, H; Burns, J A (1973). "The control of flux".
313:"Professor David Fell - Professor of Systems Biology"
155:
143:
130:
120:
102:
77:
67:
59:
41:
34:
359:
948:Symposia of the Society for Experimental Biology
8:
278:, one of the earliest papers on the use of
274:by Kacser and Burns, two research papers on
748:, Vieweg+Teubner Verlag, pp. 101ā114,
716:, Vieweg+Teubner Verlag, pp. 137ā144,
353:
351:
211:adenosine 3',5'-cyclic monophosphate (cAMP)
266:, the definition of a pathway in terms of
31:
862:
793:
688:
623:
532:
428:
887:"David Fell - Google Scholar Citations"
362:Understanding the control of metabolism
331:"David Fell - Google Scholar Citations"
301:
239:Understanding the control of metabolism
180:Understanding the control of metabolism
1014:Academics of Oxford Brookes University
7:
307:
305:
1009:Alumni of Mansfield College, Oxford
827:"A Genome-Scale Metabolic Model of
497:"The breakdown of 2,3-bis(phospho)-
625:10.1111/j.1432-1033.1985.tb08876.x
501:-glycerate by Fe(III)-haemoglobin"
14:
913:Biochemical Society Transactions
795:10.1046/j.1432-1033.2003.03390.x
782:European Journal of Biochemistry
612:European Journal of Biochemistry
655:Fell, D A; Small, J R (1986).
606:Fell, D A; Sauro, H M (1986).
565:Journal of Theoretical Biology
466:10.1113/jphysiol.1978.sp012483
1:
577:10.1016/s0022-5193(80)80011-7
722:10.1007/978-3-322-85017-1_12
16:British biochemist (b. 1947)
831:and Some of Its Properties"
754:10.1007/978-3-322-85017-1_9
746:Biomedical and Life Physics
714:Biomedical and Life Physics
1030:
276:metabolic control analysis
234:metabolic control analysis
82:metabolic control analysis
20:
454:The Journal of Physiology
317:Oxford Brookes University
176:Oxford Brookes University
165:
125:Oxford Brookes University
95:
21:Not to be confused with
230:University of Edinburgh
196:2,3-bisphosphoglycerate
23:David Fell (politician)
989:Theoretical biologists
847:10.1104/pp.109.141267
280:flux-balance analysis
90:flux balance analysis
358:Fell, David (1997).
264:small-world analysis
72:University of Oxford
1004:British biochemists
661:Biochemical Journal
505:Biochemical Journal
401:Biochemical Journal
200:Fe(III)-haemoglobin
984:Systems biologists
925:10.1042/bst0230341
366:. Portland Press.
969:Research Web Site
891:scholar.google.no
673:10.1042/bj2380781
517:10.1042/bj1770373
500:
413:10.1042/bj1390665
335:scholar.google.no
169:
168:
156:Doctoral students
97:Scientific career
1021:
956:
955:
943:
937:
936:
908:
902:
901:
899:
897:
883:
877:
876:
866:
841:(3): 1570ā1581.
835:Plant Physiology
822:
816:
815:
797:
773:
767:
766:
741:
735:
734:
709:
703:
702:
692:
652:
646:
645:
627:
603:
597:
596:
553:
547:
546:
536:
498:
492:
486:
485:
449:
443:
442:
432:
392:
386:
385:
365:
355:
346:
345:
343:
341:
327:
321:
320:
309:
268:elementary modes
248:elementary modes
243:Gillespie method
160:Herbert M. Sauro
145:Doctoral advisor
139:
86:elementary modes
55:
52:16 December 1947
51:
49:
32:
1029:
1028:
1024:
1023:
1022:
1020:
1019:
1018:
974:
973:
965:
960:
959:
945:
944:
940:
910:
909:
905:
895:
893:
885:
884:
880:
824:
823:
819:
775:
774:
770:
764:
743:
742:
738:
732:
711:
710:
706:
654:
653:
649:
618:(3): 555ā5616.
605:
604:
600:
562:
555:
554:
550:
494:
493:
489:
451:
450:
446:
394:
393:
389:
374:
357:
356:
349:
339:
337:
329:
328:
324:
311:
310:
303:
298:
272:Control of Flux
260:
222:systems biology
218:
208:
192:pyruvate kinase
188:
150:Arthur Peacocke
137:
111:network biology
107:systems biology
68:Alma mater
53:
47:
45:
37:
30:
17:
12:
11:
5:
1027:
1025:
1017:
1016:
1011:
1006:
1001:
996:
991:
986:
976:
975:
972:
971:
964:
963:External links
961:
958:
957:
938:
919:(2): 341ā366.
903:
878:
817:
788:(3): 430ā439.
768:
762:
736:
730:
704:
667:(3): 781ā786.
647:
598:
571:(2): 361ā385.
560:
548:
511:(1): 373ā375.
487:
444:
407:(3): 665ā675.
387:
372:
347:
322:
300:
299:
297:
294:
259:
256:
217:
214:
206:
187:
184:
167:
166:
163:
162:
157:
153:
152:
147:
141:
140:
134:
128:
127:
122:
118:
117:
104:
100:
99:
93:
92:
79:
78:Known for
75:
74:
69:
65:
64:
61:
57:
56:
43:
39:
38:
35:
27:D. Newlin Fell
15:
13:
10:
9:
6:
4:
3:
2:
1026:
1015:
1012:
1010:
1007:
1005:
1002:
1000:
999:Living people
997:
995:
992:
990:
987:
985:
982:
981:
979:
970:
967:
966:
962:
953:
949:
942:
939:
934:
930:
926:
922:
918:
914:
907:
904:
892:
888:
882:
879:
874:
870:
865:
860:
856:
852:
848:
844:
840:
836:
832:
830:
821:
818:
813:
809:
805:
801:
796:
791:
787:
783:
779:
772:
769:
765:
763:9783322850195
759:
755:
751:
747:
740:
737:
733:
731:9783322850195
727:
723:
719:
715:
708:
705:
700:
696:
691:
686:
682:
678:
674:
670:
666:
662:
658:
651:
648:
643:
639:
635:
631:
626:
621:
617:
613:
609:
602:
599:
594:
590:
586:
582:
578:
574:
570:
566:
559:
552:
549:
544:
540:
535:
530:
526:
522:
518:
514:
510:
506:
502:
491:
488:
483:
479:
475:
471:
467:
463:
459:
455:
448:
445:
440:
436:
431:
426:
422:
418:
414:
410:
406:
402:
398:
391:
388:
383:
379:
375:
373:9781855780477
369:
364:
363:
354:
352:
348:
336:
332:
326:
323:
318:
314:
308:
306:
302:
295:
293:
291:
290:
285:
281:
277:
273:
269:
265:
257:
255:
253:
249:
244:
240:
235:
231:
227:
226:Henrik Kacser
223:
215:
213:
212:
205:
201:
197:
193:
185:
183:
181:
177:
173:
172:David A. Fell
164:
161:
158:
154:
151:
148:
146:
142:
135:
133:
129:
126:
123:
119:
116:
112:
108:
105:
101:
98:
94:
91:
87:
83:
80:
76:
73:
70:
66:
62:
58:
54:(age 76)
44:
40:
33:
28:
24:
19:
951:
947:
941:
916:
912:
906:
896:25 September
894:. Retrieved
890:
881:
838:
834:
828:
820:
785:
781:
771:
745:
739:
713:
707:
664:
660:
650:
615:
611:
601:
568:
564:
557:
551:
508:
504:
490:
457:
453:
447:
404:
400:
390:
361:
338:. Retrieved
334:
325:
316:
287:
284:MAPK pathway
271:
261:
258:Publications
251:
238:
219:
216:Later career
203:
189:
179:
171:
170:
121:Institutions
96:
18:
994:1947 births
829:Arabidopsis
289:Arabidopsis
252:Arabidopsis
60:Nationality
978:Categories
296:References
186:Early work
48:1947-12-16
36:David Fell
954:: 65ā104.
855:0032-0889
804:0014-2956
681:0264-6021
634:0014-2956
585:0022-5193
525:0264-6021
482:222217462
460:: 3Pā4P.
421:0264-6021
382:553392040
340:31 August
182:in 1996.
873:19755544
812:12542693
115:genetics
933:7672373
864:2773075
699:3800960
690:1147204
642:3996393
593:6251314
534:1186379
439:4369339
430:1166331
228:at the
63:British
931:
871:
861:
853:
810:
802:
760:
728:
697:
687:
679:
640:
632:
591:
583:
543:426777
541:
531:
523:
480:
472:
437:
427:
419:
380:
370:
138:(1974)
136:
132:Thesis
103:Fields
478:S2CID
474:31462
929:PMID
898:2018
869:PMID
851:ISSN
808:PMID
800:ISSN
758:ISBN
726:ISBN
695:PMID
677:ISSN
638:PMID
630:ISSN
589:PMID
581:ISSN
539:PMID
521:ISSN
470:PMID
458:2823
435:PMID
417:ISSN
378:OCLC
368:ISBN
342:2020
42:Born
921:doi
859:PMC
843:doi
839:151
790:doi
786:270
750:doi
718:doi
685:PMC
669:doi
665:238
620:doi
616:148
573:doi
529:PMC
513:doi
509:177
462:doi
425:PMC
409:doi
405:139
198:by
25:or
980::
952:27
950:.
927:.
917:23
915:.
889:.
867:.
857:.
849:.
837:.
833:.
806:.
798:.
784:.
780:.
756:,
724:,
693:.
683:.
675:.
663:.
659:.
636:.
628:.
614:.
610:.
587:.
579:.
569:84
567:.
537:.
527:.
519:.
507:.
503:.
476:.
468:.
456:.
433:.
423:.
415:.
403:.
399:.
376:.
350:^
333:.
315:.
304:^
292:.
254:.
113:,
109:,
88:,
84:,
50:)
935:.
923::
900:.
875:.
845::
814:.
792::
752::
720::
701:.
671::
644:.
622::
595:.
575::
561:m
558:K
545:.
515::
499:D
484:.
464::
441:.
411::
384:.
344:.
319:.
207:m
204:K
46:(
29:.
Text is available under the Creative Commons Attribution-ShareAlike License. Additional terms may apply.