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Deer tick virus

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died from the virus. After an autopsy, his tissues were found to have DTV on a PCR assay. The patient had no history of travel in the days before his admission to the hospital, which implies that the virus might be active in the New York area. He spent times outdoors in woodland areas and had
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El Khoury, Marc; Camargo, Jose; White, Jennifer; Backenson, Bryon; Dupuis, Alan; Escuyer, Kayer; Kramer, Laura; George, Kirsten; Chatterjee, Debarati; Prusinski, Melissa; Wormser, Gary; Wong, Susan (19 December 2013).
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Cavanaugh, Catherine; Muscat, Paul; Telford, Sam; Goethert, Heidi; Pendlebury, William; Elias, Susan; Robich, Rebecca; Welch, Margret; Lubelczyk, Charles; Smith, Robert (15 September 2017).
1880: 647:"Isolation of deer tick virus (Powassan virus, lineage II) from Ixodes scapularis and detection of antibody in vertebrate hosts sampled in the Hudson Valley, New York State" 821: 1636: 2111: 1890: 431:
in the same area the tick was removed from. She developed several other concerning symptoms towards the end of her admission at the hospital, which ranged from
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was commonly reported in the patient's area of residence, showing that tick activity was prevalent in the patient's area (at the time of admission).
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indicating the relationship of deer tick virus to other tick-borne encephalitis group viruses. TBE, tick-borne encephalitis; TSE,
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Values above branches indicate bootstrapped confidence values. Branch lengths are proportional to percent similarity in sequence.
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Dupuis II, Alan P; Peters, Ryan J; Prusinski, Melissa A; Falco, Richard C; Ostfeld, Richard S; Kramer, Laura D (2013-07-15).
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tick was removed from her left scapula only three weeks after the first tick had been removed. She later developed
2116: 1806: 1269: 707:"Potential Role of Deer Tick Virus in Powassan Encephalitis Cases in Lyme Disease–endemic Areas of New York, USA" 451:), which provided no relief to her illness. She later died and a limited autopsy was performed. A severe loss of 1161: 348:
ticks in the northern United States are possibly infected with DTV. This infers that the virus is not seriously
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filled with amorphous masses of pinkstaining (=Feulgen positive) material (arrows). Scale bar = 10 Âµm.
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In 2017, another fatal case of DTV was documented when a 72-year-old woman was admitted to a hospital in
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or it does not easily infect humans. Human incidence might be severely underestimated.
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DTV has a strong prevalence in the northeastern and north central part of the
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Tavakoli NP, Wang H, Dupuis M, Hull R, Ebel GD, Gilmore EJ, Faust PL (2009).
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Kuno G, Artsob H, Karabatsos N, Tsuchiya KR, Chang GJ (November 2001).
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hospital when a 62-year-old man with a meningoencephalitis syndrome,
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identity). Due to their close similarities, DTV is also called
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a rash that is often seen in the early stages of Lyme disease
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Telford SR, Armstrong PM, Katavolos P, et al. (1997).
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Avoid possible tick-infested areas, such as the woodlands
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tick was removed from her left breast. Another embedded
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of the brain were discovered. A considerable loss of
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A month before her admission, an 14: 1130:Western equine encephalomyelitis 1120:Eastern equine encephalomyelitis 68: 1255:Crimean–Congo hemorrhagic fever 1417:Kemerovo tickborne viral fever 360:In 1997, it was isolated from 1: 1674:Hantavirus pulmonary syndrome 913:Jamestown Canyon encephalitis 319:Kyasanur Forest disease virus 1568:Venezuelan hemorrhagic fever 569:Clinical Infectious Diseases 463:was evident in the patient. 455:within the spinal cord and 1590:Brazilian hemorrhagic fever 1578:Argentine hemorrhagic fever 2166: 1602:Bolivian hemorrhagic fever 1482:Sandfly fever Naples virus 315:Spanish sheep encephalitis 303:Turkish sheep encephalitis 1270:Huaiyangshan banyangvirus 623:10.4269/ajtmh.2001.65.671 439:. She was given doses of 277:Powassan virus lineage II 63: 35: 26: 21: 2150:Infraspecific virus taxa 1886:SARS-related coronavirus 1849:Henipavirus encephalitis 1707:Murid gammaherpesvirus 4 1552:Viral hemorrhagic fevers 1333:Viral hemorrhagic fevers 1305:Arbovirus encephalitides 1281:Arbovirus encephalitides 1251:Viral hemorrhagic fevers 1216:Banna virus encephalitis 1116:Arbovirus encephalitides 1061:Viral hemorrhagic fevers 1027:Saint Louis encephalitis 994:Arbovirus encephalitides 945:Viral hemorrhagic fevers 879:Arbovirus encephalitides 1990:Yaba monkey tumor virus 1347:Kyasanur Forest disease 1309:Tick-borne encephalitis 1010:Australian encephalitis 903:California encephalitis 664:10.1186/1756-3305-6-185 651:Parasites & Vectors 388:frequent contacts with 307:Greek goat encephalitis 1337:Omsk hemorrhagic fever 918:La Crosse encephalitis 772:10.3201/eid0302.970209 723:10.3201/eid1912.130903 332: 263:DTV closely resembles 43:depicting intact tick 1770:Marburg virus disease 1321:Powassan encephalitis 998:Japanese encephalitis 610:Am. J. Trop. Med. Hyg 527:10.1056/NEJMoa0806326 297: 267:(to which it has 84% 1196:Semliki Forest virus 760:Emerging Infect. Dis 65:Virus classification 1743:Ebola virus disease 1407:Colorado tick fever 1162:O'nyong'nyong fever 457:meningoencephalitis 453:anterior horn cells 364:ticks collected in 327:Saumarez Reef virus 288:Peromyscus leucopus 273:amino acid sequence 269:nucleotide sequence 2145:Viral encephalitis 1955:Simian foamy virus 582:10.1093/cid/cix435 409:urination problems 405:low blood pressure 385:maculopapular rash 333: 2127: 2126: 2080:Taxon identifiers 2071: 2070: 2067: 2066: 2063: 2062: 1998: 1997: 1906: 1905: 1716: 1715: 1514: 1513: 1510: 1509: 1425: 1424: 1224: 1223: 969:Rift Valley fever 521:(20): 2099–2107. 443:and antibiotics ( 311:louping ill virus 282:Ixodes scapularis 271:identity and 94% 228: 227: 202:Medical condition 200: 199: 2157: 2120: 2119: 2107: 2106: 2105: 2075: 2009: 1919: 1729: 1538: 1527: 1502:Chandipura virus 1438: 1378:Orthomyxoviridae 1237: 1184:Ross River fever 949:Bunyamwera fever 865: 854: 824: 817: 810: 801: 794: 793: 783: 751: 745: 744: 734: 711:Emerg Infect Dis 701: 695: 694: 684: 666: 642: 636: 635: 625: 601: 595: 594: 584: 575:(6): 1043–1046. 560: 549: 548: 538: 506: 437:thrombocytopenia 205: 73: 72: 36:Black and white 31: 22:Deer tick virus 19: 2165: 2164: 2160: 2159: 2158: 2156: 2155: 2154: 2130: 2129: 2128: 2123: 2115: 2110: 2101: 2100: 2095: 2088:Deer tick virus 2082: 2072: 2059: 2039: 2004: 1994: 1969: 1939: 1913: 1902: 1865: 1840:Paramyxoviridae 1833: 1786: 1723: 1712: 1690: 1621: 1532: 1521: 1506: 1486: 1470:Pappataci fever 1463:Oropouche virus 1458:Oropouche fever 1432: 1421: 1391: 1371: 1289: 1261:Heartland virus 1231: 1220: 1200: 1172:Pogosta disease 1100: 1047:West Nile fever 978: 859: 848: 841: 828: 798: 797: 753: 752: 748: 717:(12): 1926–33. 703: 702: 698: 644: 643: 639: 603: 602: 598: 562: 561: 552: 515:N. Engl. J. Med 508: 507: 496: 491: 469: 358: 338: 330: 261: 231:Deer tick virus 208:Deer tick virus 203: 196: 194:Deer tick virus 184: 144:Amarillovirales 120:Kitrinoviricota 67: 49:deer tick virus 45:salivary glands 41:microphotograph 38:Feulgen stained 17: 12: 11: 5: 2163: 2161: 2153: 2152: 2147: 2142: 2132: 2131: 2125: 2124: 2122: 2121: 2108: 2092: 2090: 2084: 2083: 2078: 2069: 2068: 2065: 2064: 2061: 2060: 2058: 2057: 2051: 2049: 2041: 2040: 2038: 2037: 2032: 2031: 2030: 2019: 2017: 2006: 2000: 1999: 1996: 1995: 1993: 1992: 1987: 1981: 1979: 1971: 1970: 1968: 1967: 1962: 1957: 1951: 1949: 1941: 1940: 1938: 1937: 1929: 1927: 1916: 1908: 1907: 1904: 1903: 1901: 1900: 1899: 1898: 1893: 1883: 1877: 1875: 1867: 1866: 1864: 1863: 1862: 1861: 1856: 1845: 1843: 1835: 1834: 1832: 1831: 1826: 1825: 1824: 1819: 1814: 1809: 1798: 1796: 1788: 1787: 1785: 1784: 1783: 1782: 1777: 1767: 1766: 1765: 1760: 1755: 1750: 1739: 1737: 1726: 1718: 1717: 1714: 1713: 1711: 1710: 1702: 1700: 1692: 1691: 1689: 1688: 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2021: 2020: 2018: 2016: 2015: 2014:Rhabdoviridae 2010: 2007: 2001: 1991: 1988: 1986: 1983: 1982: 1980: 1978: 1977: 1972: 1966: 1963: 1961: 1958: 1956: 1953: 1952: 1950: 1948: 1947: 1942: 1936: 1935: 1931: 1930: 1928: 1926: 1925: 1924:Herpesviridae 1920: 1917: 1915: 1909: 1897: 1894: 1892: 1889: 1888: 1887: 1884: 1882: 1879: 1878: 1876: 1874: 1873: 1872:Coronaviridae 1868: 1860: 1857: 1855: 1852: 1851: 1850: 1847: 1846: 1844: 1842: 1841: 1836: 1830: 1827: 1823: 1820: 1818: 1815: 1813: 1810: 1808: 1805: 1804: 1803: 1800: 1799: 1797: 1795: 1794: 1793:Rhabdoviridae 1789: 1781: 1778: 1776: 1773: 1772: 1771: 1768: 1764: 1761: 1759: 1756: 1754: 1751: 1749: 1746: 1745: 1744: 1741: 1740: 1738: 1736: 1735: 1730: 1727: 1725: 1719: 1709: 1708: 1704: 1703: 1701: 1699: 1698: 1697:Herpesviridae 1693: 1685: 1682: 1680: 1677: 1676: 1675: 1672: 1668: 1665: 1663: 1660: 1658: 1655: 1653: 1650: 1648: 1645: 1643: 1640: 1639: 1638: 1635: 1634: 1632: 1630: 1629: 1624: 1618: 1615: 1613: 1610: 1605: 1604: 1603: 1600: 1596: 1593: 1592: 1591: 1588: 1584: 1581: 1580: 1579: 1576: 1571: 1570: 1569: 1566: 1562: 1559: 1558: 1557: 1553: 1550: 1549: 1547: 1545: 1544: 1539: 1536: 1534: 1528: 1525: 1523: 1517: 1503: 1500: 1499: 1497: 1495: 1494: 1493:Rhabdoviridae 1489: 1483: 1480: 1476: 1475:Toscana virus 1473: 1472: 1471: 1468: 1464: 1461: 1460: 1459: 1456: 1453: 1450: 1449: 1447: 1445: 1444: 1439: 1436: 1434: 1428: 1418: 1415: 1410: 1409: 1408: 1405: 1404: 1402: 1400: 1399: 1394: 1388: 1387:Bourbon virus 1385: 1384: 1382: 1380: 1379: 1374: 1365: 1364: 1363: 1360: 1356: 1353: 1350: 1349: 1348: 1345: 1340: 1339: 1338: 1334: 1331: 1327: 1324: 1323: 1322: 1319: 1315: 1312: 1311: 1310: 1306: 1303: 1302: 1300: 1298: 1297: 1292: 1286: 1282: 1279: 1277: 1274: 1271: 1267: 1264: 1262: 1259: 1256: 1252: 1249: 1248: 1246: 1244: 1243: 1238: 1235: 1233: 1227: 1217: 1214: 1213: 1211: 1209: 1208: 1203: 1197: 1194: 1190: 1187: 1186: 1185: 1182: 1178: 1177:Sindbis virus 1175: 1174: 1173: 1170: 1165: 1164: 1163: 1160: 1156: 1153: 1152: 1151: 1148: 1143: 1142: 1141: 1138: 1133: 1132: 1131: 1128: 1123: 1122: 1121: 1117: 1114: 1113: 1111: 1109: 1108: 1103: 1095: 1092: 1091: 1090: 1087: 1083: 1080: 1079: 1078: 1075: 1071: 1068: 1067: 1066: 1062: 1059: 1058: 1053: 1050: 1049: 1048: 1045: 1040: 1039: 1038: 1035: 1030: 1029: 1028: 1025: 1021: 1018: 1016: 1013: 1012: 1011: 1008: 1004: 1001: 1000: 999: 995: 992: 991: 989: 987: 986: 981: 972: 971: 970: 967: 962: 961: 960: 957: 952: 951: 950: 946: 943: 942: 939: 936: 931: 930: 929: 926: 921: 920: 919: 916: 914: 911: 906: 905: 904: 901: 896: 895: 894: 891: 886: 885: 884: 880: 877: 876: 874: 872: 871: 866: 863: 861: 855: 852: 850: 844: 839: 835: 832: 825: 820: 818: 813: 811: 806: 805: 802: 791: 787: 782: 777: 773: 769: 766:(2): 165–70. 765: 761: 757: 750: 747: 742: 738: 733: 728: 724: 720: 716: 712: 708: 700: 697: 692: 688: 683: 678: 674: 670: 665: 660: 656: 652: 648: 641: 638: 633: 629: 624: 619: 615: 611: 607: 600: 597: 592: 588: 583: 578: 574: 570: 566: 559: 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1732: 1705: 1695: 1628:Bunyavirales 1626: 1543:Arenaviridae 1541: 1491: 1443:Bunyavirales 1441: 1396: 1376: 1362:Langat virus 1296:Flaviviridae 1294: 1285:Bhanja virus 1242:Bunyavirales 1240: 1205: 1105: 1077:Yellow fever 1065:Dengue fever 985:Flaviviridae 983: 928:Tahyna virus 893:Bwamba Fever 870:Bunyavirales 868: 763: 759: 749: 714: 710: 699: 654: 650: 640: 616:(5): 671–6. 613: 609: 599: 572: 568: 518: 514: 483:Lyme disease 421:muscle aches 416: 412: 398: 394:Lyme disease 374: 361: 359: 345: 339: 336:Epidemiology 286: 280: 276: 262: 253:encephalitis 251:that causes 242: 234: 230: 229: 193: 179: 167: 156:Flaviviridae 155: 143: 131: 119: 107: 95: 88: 78:(unranked): 53:Hypotrophied 48: 47:infected by 1734:Filoviridae 1556:Lassa fever 1452:Adria virus 1150:Chikungunya 1107:Togaviridae 1037:Usutu virus 959:Ngari virus 883:Batai virus 478:Louping ill 441:doxycycline 433:joint pains 370:Connecticut 247:spread via 2134:Categories 2046:Poxviridae 1976:Poxviridae 1896:SARS-CoV-2 1398:Reoviridae 1276:Tete virus 1207:Reoviridae 1089:Zika fever 938:Tete virus 836:(A80–B34, 445:vancomycin 350:pathogenic 244:Flavivirus 213:Prevention 168:Flavivirus 2055:Monkeypox 847:Arthropod 673:1756-3305 489:Footnotes 449:meropenem 299:Phylogram 175:Species: 103:Kingdom: 96:Riboviria 55:salivary 2103:Q5250868 2097:Wikidata 2003:Multiple 1891:SARS-CoV 1881:MERS-CoV 1070:DENV-1-4 858:Mosquito 831:Zoonotic 741:24274334 691:24016533 632:11716135 591:28903511 545:19439744 467:See also 377:New York 259:Taxonomy 151:Family: 115:Phylum: 2005:vectors 1985:Tanapox 1934:B virus 1912:Primate 1431:Sandfly 1257:(CCHFV) 838:042–079 790:9204297 781:2627606 732:3840892 682:3711734 657:: 185. 536:2847876 356:History 325:; SRE, 321:; TYU, 317:; KFD, 313:; SSE, 305:; GGE, 237:) is a 189:Virus: 163:Genus: 139:Order: 127:Class: 2023:Rabies 1965:HTLV-2 1960:HTLV-1 1914:-borne 1802:Rabies 1724:-borne 1533:-borne 1531:Rodent 1522:-borne 1520:Mammal 1454:(ADRV) 1433:-borne 1232:-borne 860:-borne 849:-borne 788:  778:  739:  729:  689:  679:  671:  630:  589:  543:  533:  427:, and 425:chills 407:, and 390:horses 309:; LI, 221:Deaths 57:acinus 2117:58535 1763:ZEBOV 1667:THAIV 1155:CHIKV 401:Maine 381:fever 249:ticks 239:virus 89:Realm 82:Virus 2112:NCBI 2028:RABV 1829:CHPV 1817:DUVV 1812:MOKV 1807:ABLV 1780:RAVV 1775:MARV 1758:TAFV 1753:SUDV 1748:BDBV 1679:ANDV 1662:AMRV 1657:SEOV 1652:PUUV 1647:HTNV 1642:DOBV 1617:CHPV 1612:LUJV 1606:MACV 1595:SABV 1583:JUNV 1572:GTOV 1561:LASV 1411:CTFV 1366:LGTV 1355:AHFV 1351:KFDV 1341:OHFV 1326:POWV 1314:TBEV 1230:Tick 1166:ONNV 1144:VEEV 1134:WEEV 1124:EEEV 1094:ZIKV 1041:USUV 1031:SLEV 1020:KUNV 1015:MVEV 973:RVFV 963:NRIV 953:BUNV 932:TAHV 922:LACV 897:BWAV 887:BATV 786:PMID 737:PMID 687:PMID 669:ISSN 628:PMID 587:PMID 541:PMID 447:and 368:and 1859:NiV 1854:HeV 1822:LBV 1722:Bat 1684:SNV 1189:RRV 1082:YFV 1052:WNV 1003:JEV 907:CEV 776:PMC 768:doi 727:PMC 719:doi 677:PMC 659:doi 618:doi 577:doi 531:PMC 523:doi 519:360 435:to 291:). 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Index

Black and white Feulgen stained microphotograph depicting intact tick salivary glands infected by deer tick virus. Hypotrophied salivary acinus filled with amorphous masses of pinkstaining (=Feulgen positive) material (arrows). Scale bar = 10 µm.
Feulgen stained
microphotograph
salivary glands
Hypotrophied
acinus
Virus classification
Edit this classification
Virus
Riboviria
Orthornavirae
Kitrinoviricota
Flasuviricetes
Amarillovirales
Flaviviridae
Flavivirus
Powassan virus
virus
Flavivirus
ticks
encephalitis
Powassan virus
nucleotide sequence
amino acid sequence
Ixodes scapularis
Peromyscus leucopus

Phylogram
Turkish sheep encephalitis
Greek goat encephalitis

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