189:. Dentin phosphoprotein is thought to be involved in the biomineralization process of dentin. Mutations in this gene have been associated with dentinogenesis imperfecta-1; in some individuals, dentinogenesis imperfecta occurs in combination with an autosomal dominant form of deafness. Allelic differences due to repeat polymorphisms have been found for this gene.
161:) inside the teeth (dental pulp), and in smaller quantities by bone tissues (osteoblasts and osteocytes). It is required for normal hardening (mineralisation) of teeth. During teeth development, it is broken down into three proteins such as dentin sialoprotein (DSP), dentin glycoprotein (DGP), and dentin phosphoprotein (DPP). These proteins become the major non-
169:
matrix of the forming dentin suggests these proteins play an important role in the regulation of mineral deposition. Additional evidence for this correlation is phenotypically manifested in patients with mutant forms of dentin sialophosphoprotein. Such patients suffer dental anomalies including
185:) present on human chromosome 4. This gene encodes two principal proteins of the dentin extracellular matrix of the tooth. The preproprotein is secreted by odontoblasts and cleaved into dentin sialoprotein and
329:"Dentin phosphoprotein and dentin sialoprotein are cleavage products expressed from a single transcript coded by a gene on human chromosome 4. Dentin phosphoprotein DNA sequence determination"
533:
Buchaille R, Couble ML, Magloire H, Bleicher F (2000). "A substractive PCR-based cDNA library from human odontoblast cells: identification of novel genes expressed in tooth forming cells".
383:
MacDougall M, Simmons D, Luan X, et al. (1998). "Assignment of dentin sialophosphoprotein (DSPP) to the critical DGI2 locus on human chromosome 4 band q21.3 by in situ hybridization".
412:
MacDougall M (1998). "Refined mapping of the human dentin sialophosphoprotein (DSPP) gene within the critical dentinogenesis imperfecta type II and dentin dysplasia type II loci".
253:
599:
Xiao S, Yu C, Chou X, et al. (2001). "Dentinogenesis imperfecta 1 with or without progressive hearing loss is associated with distinct mutations in DSPP".
50:
741:"Phosphophoryn regulates the gene expression and differentiation of NIH3T3, MC3T3-E1, and human mesenchymal stem cells via the integrin/MAPK signaling pathway"
636:
Papagerakis P, Berdal A, Mesbah M, et al. (2002). "Investigation of osteocalcin, osteonectin, and dentin sialophosphoprotein in developing human teeth".
985:
975:
74:
279:
62:
55:
932:"Dentin matrix protein 1 regulates dentin sialophosphoprotein gene transcription during early odontoblast differentiation"
488:
990:
442:
846:"Expression of dentin sialophosphoprotein in human prostate cancer and its correlation with tumor aggressiveness"
171:
665:
Qin C, Brunn JC, Cadena E, et al. (2002). "The expression of dentin sialophosphoprotein gene in bone".
206:
Yamamoto R, Oida S, Yamakoshi Y (2015). "Dentin
Sialophosphoprotein–derived Proteins in the Dental Pulp".
562:
Zhang X, Zhao J, Li C, et al. (2001). "DSPP mutation in dentinogenesis imperfecta
Shields type II".
362:
Dean JA, Hartsfield JK, Wright JT, Hart TC (1998). "Dentin dysplasia, type II linkage to chromosome 4q".
67:
186:
108:
702:
Ogbureke KU, Fisher LW (2004). "Expression of SIBLINGs and their partner MMPs in salivary glands".
875:
727:
690:
624:
587:
231:
953:
918:
867:
832:
797:
762:
719:
682:
653:
616:
579:
550:
521:
475:
429:
400:
371:
350:
315:
223:
943:
908:
900:
857:
822:
787:
752:
711:
674:
645:
608:
571:
542:
511:
503:
465:
457:
421:
392:
340:
307:
215:
103:
112:
132:
776:"Renal expression of SIBLING proteins and their partner matrix metalloproteinases (MMPs)"
980:
913:
888:
425:
311:
157:
is a precursor protein for other proteins found in the teeth. It is produced by cells (
649:
546:
969:
792:
775:
507:
879:
731:
628:
235:
889:"Phenotypic variation in dentinogenesis imperfecta/dentin dysplasia linked to 4q21"
694:
591:
811:"Dentin sialoprotein and dentin phosphoprotein overexpression during amelogenesis"
461:
158:
142:
904:
715:
678:
86:
219:
957:
948:
931:
922:
871:
836:
827:
810:
801:
766:
757:
740:
723:
686:
657:
620:
583:
554:
525:
227:
479:
433:
404:
375:
354:
345:
328:
319:
516:
470:
166:
162:
91:
862:
845:
396:
612:
575:
79:
930:
Narayanan K, Gajjeraman S, Ramachandran A, et al. (2006).
443:"Human dentin phosphophoryn nucleotide and amino acid sequence"
267:
Ten Cate's Oral
Histology: Development, Structure, and Function
489:"Molecular cloning of a human dentin sialophosphoprotein gene"
16:
Precursor protein for other proteins found in the teeth
844:
Chaplet M, Waltregny D, Detry C, et al. (2006).
327:
MacDougall M, Simmons D, Luan X, et al. (1997).
269:. 7th ed. St. Louis, MO: Mosby Elsevier, 2008. Print.
138:
128:
123:
102:
97:
85:
73:
61:
49:
41:
33:
28:
23:
739:Jadlowiec J, Koch H, Zhang X, et al. (2005).
887:Beattie ML, Kim JW, Gong SG, et al. (2006).
487:Gu K, Chang S, Ritchie HH, et al. (2000).
441:Gu K, Chang SR, Slaven MS, et al. (1999).
165:components of teeth. Their distribution in the
809:Paine ML, Luo W, Wang HJ, et al. (2005).
280:"Entrez Gene: DSPP dentin sialophosphoprotein"
254:Columbia University College of Dental Medicine
8:
298:Butler WT (1998). "Dentin matrix proteins".
120:
947:
912:
861:
826:
791:
756:
515:
469:
344:
250:Biology of Mineralized Tissue coursenotes
177:It is coded by a gene of the same name (
198:
20:
7:
426:10.1111/j.1600-0722.1998.tb02180.x
312:10.1111/j.1600-0722.1998.tb02177.x
14:
793:10.1111/j.1523-1755.2005.00389.x
508:10.1034/j.1600-0722.2000.00765.x
774:Ogbureke KU, Fisher LW (2005).
364:J. Craniofac. Genet. Dev. Biol
1:
986:Extracellular matrix proteins
650:10.1016/S8756-3282(01)00683-4
547:10.1016/S0945-053X(00)00091-3
462:10.1046/j.0909-8836..t01-9-.x
976:Genes on human chromosome 4
1007:
905:10.1177/154405910608500409
716:10.1177/154405910408300902
679:10.1177/154405910208100607
208:Journal of Dental Research
179:dentin sialophosphoprotein
155:Dentin sialophosphoprotein
24:Dentin sialophosphoprotein
172:dentinogenesis imperfecta
119:
220:10.1177/0022034515585715
949:10.1074/jbc.M600714200
828:10.1074/jbc.M502991200
758:10.1074/jbc.M404934200
248:Letty Moss-Salentijn,
385:Cytogenet. Cell Genet
346:10.1074/jbc.272.2.835
187:dentin phosphoprotein
45:Dentin Phosphophoryn
420:(Suppl 1): 227–33.
306:(Suppl 1): 204–10.
991:Precursor proteins
863:10.1002/ijc.21442
397:10.1159/000134697
152:
151:
148:
147:
998:
961:
951:
942:(28): 19064–71.
926:
916:
883:
865:
840:
830:
805:
795:
770:
760:
751:(51): 53323–30.
735:
698:
661:
632:
595:
558:
529:
519:
496:Eur. J. Oral Sci
493:
483:
473:
450:Eur. J. Oral Sci
447:
437:
414:Eur. J. Oral Sci
408:
379:
358:
348:
323:
300:Eur. J. Oral Sci
284:
283:
276:
270:
265:Nanci, Antonio.
263:
257:
246:
240:
239:
214:(8): 1120–1127.
203:
121:
21:
1006:
1005:
1001:
1000:
999:
997:
996:
995:
966:
965:
964:
929:
886:
843:
821:(36): 31991–8.
808:
773:
738:
701:
664:
635:
598:
561:
532:
491:
486:
445:
440:
411:
382:
361:
326:
297:
293:
291:Further reading
288:
287:
278:
277:
273:
264:
260:
247:
243:
205:
204:
200:
195:
17:
12:
11:
5:
1004:
1002:
994:
993:
988:
983:
978:
968:
967:
963:
962:
927:
884:
850:Int. J. Cancer
841:
806:
771:
736:
699:
662:
633:
596:
559:
530:
484:
438:
409:
391:(1–2): 121–2.
380:
359:
324:
294:
292:
289:
286:
285:
271:
258:
241:
197:
196:
194:
191:
150:
149:
146:
145:
140:
136:
135:
130:
126:
125:
117:
116:
106:
100:
99:
95:
94:
89:
83:
82:
77:
71:
70:
65:
59:
58:
53:
47:
46:
43:
39:
38:
35:
31:
30:
26:
25:
15:
13:
10:
9:
6:
4:
3:
2:
1003:
992:
989:
987:
984:
982:
979:
977:
974:
973:
971:
959:
955:
950:
945:
941:
937:
936:J. Biol. Chem
933:
928:
924:
920:
915:
910:
906:
902:
899:(4): 329–33.
898:
894:
890:
885:
881:
877:
873:
869:
864:
859:
855:
851:
847:
842:
838:
834:
829:
824:
820:
816:
815:J. Biol. Chem
812:
807:
803:
799:
794:
789:
786:(1): 155–66.
785:
781:
777:
772:
768:
764:
759:
754:
750:
746:
745:J. Biol. Chem
742:
737:
733:
729:
725:
721:
717:
713:
710:(9): 664–70.
709:
705:
700:
696:
692:
688:
684:
680:
676:
672:
668:
663:
659:
655:
651:
647:
644:(2): 377–85.
643:
639:
634:
630:
626:
622:
618:
614:
613:10.1038/84848
610:
606:
602:
597:
593:
589:
585:
581:
577:
576:10.1038/84765
573:
569:
565:
560:
556:
552:
548:
544:
541:(5): 421–30.
540:
536:
531:
527:
523:
518:
517:2027.42/71920
513:
509:
505:
501:
497:
490:
485:
481:
477:
472:
471:2027.42/75305
467:
463:
459:
456:(6): 1043–7.
455:
451:
444:
439:
435:
431:
427:
423:
419:
415:
410:
406:
402:
398:
394:
390:
386:
381:
377:
373:
369:
365:
360:
356:
352:
347:
342:
339:(2): 835–42.
338:
334:
333:J. Biol. Chem
330:
325:
321:
317:
313:
309:
305:
301:
296:
295:
290:
281:
275:
272:
268:
262:
259:
255:
251:
245:
242:
237:
233:
229:
225:
221:
217:
213:
209:
202:
199:
192:
190:
188:
184:
180:
175:
173:
168:
164:
160:
156:
144:
141:
137:
134:
131:
127:
122:
118:
115:
114:
110:
107:
105:
101:
96:
93:
90:
88:
84:
81:
78:
76:
72:
69:
66:
64:
60:
57:
54:
52:
48:
44:
40:
36:
32:
27:
22:
19:
939:
935:
896:
893:J. Dent. Res
892:
856:(4): 850–6.
853:
849:
818:
814:
783:
779:
748:
744:
707:
704:J. Dent. Res
703:
673:(6): 392–4.
670:
667:J. Dent. Res
666:
641:
637:
607:(2): 201–4.
604:
600:
570:(2): 151–2.
567:
563:
538:
534:
502:(1): 35–42.
499:
495:
453:
449:
417:
413:
388:
384:
370:(4): 172–7.
367:
363:
336:
332:
303:
299:
274:
266:
261:
249:
244:
211:
207:
201:
182:
178:
176:
159:odontoblasts
154:
153:
111:
18:
535:Matrix Biol
163:collagenous
133:Swiss-model
29:Identifiers
970:Categories
780:Kidney Int
601:Nat. Genet
564:Nat. Genet
193:References
129:Structures
124:Search for
98:Other data
42:Alt. names
170:type III
51:NCBI gene
958:16679514
923:16567553
880:12370385
872:16108038
837:16014627
802:15954904
767:15371433
732:17978869
724:15329369
687:12097430
658:11856645
629:22276124
621:11175790
584:11175779
555:10980418
526:10706475
236:24609252
228:25951824
167:collagen
143:InterPro
914:2238637
695:6384427
592:9692054
480:9879917
434:9541230
405:9533027
376:9493074
355:8995371
320:9541227
139:Domains
87:UniProt
956:
921:
911:
878:
870:
835:
800:
765:
730:
722:
693:
685:
656:
627:
619:
590:
582:
553:
524:
478:
432:
403:
374:
353:
318:
256:, 2009
234:
226:
109:Chr. 4
92:Q9NZW4
80:125485
34:Symbol
981:Teeth
876:S2CID
728:S2CID
691:S2CID
625:S2CID
588:S2CID
492:(PDF)
446:(PDF)
232:S2CID
181:, or
113:q22.1
104:Locus
954:PMID
919:PMID
868:PMID
833:PMID
798:PMID
763:PMID
720:PMID
683:PMID
654:PMID
638:Bone
617:PMID
580:PMID
551:PMID
522:PMID
476:PMID
430:PMID
401:PMID
372:PMID
351:PMID
316:PMID
224:PMID
183:DSPP
75:OMIM
68:3054
63:HGNC
56:1834
37:DSPP
944:doi
940:281
909:PMC
901:doi
858:doi
854:118
823:doi
819:280
788:doi
753:doi
749:279
712:doi
675:doi
646:doi
609:doi
572:doi
543:doi
512:hdl
504:doi
500:108
466:hdl
458:doi
454:106
422:doi
418:106
393:doi
341:doi
337:272
308:doi
304:106
216:doi
972::
952:.
938:.
934:.
917:.
907:.
897:85
895:.
891:.
874:.
866:.
852:.
848:.
831:.
817:.
813:.
796:.
784:68
782:.
778:.
761:.
747:.
743:.
726:.
718:.
708:83
706:.
689:.
681:.
671:81
669:.
652:.
642:30
640:.
623:.
615:.
605:27
603:.
586:.
578:.
568:27
566:.
549:.
539:19
537:.
520:.
510:.
498:.
494:.
474:.
464:.
452:.
448:.
428:.
416:.
399:.
389:79
387:.
368:17
366:.
349:.
335:.
331:.
314:.
302:.
252:,
230:.
222:.
212:94
210:.
174:.
960:.
946::
925:.
903::
882:.
860::
839:.
825::
804:.
790::
769:.
755::
734:.
714::
697:.
677::
660:.
648::
631:.
611::
594:.
574::
557:.
545::
528:.
514::
506::
482:.
468::
460::
436:.
424::
407:.
395::
378:.
357:.
343::
322:.
310::
282:.
238:.
218::
Text is available under the Creative Commons Attribution-ShareAlike License. Additional terms may apply.