101:
in chronic pain patients. DNIC inefficiency (or lower DNIC) has been implicated as a risk factor for development of chronic pain and pain syndromes. Chronic pain disorders such as temporomandibular disorder and fibromyalgia have been associated with DNIC inefficiency. On the other hand, greater DNIC
62:
responsive to stimulation from one location of the body may be inhibited by noxious stimuli (such as heat, high pressure or electric stimulation) applied to another, remote location in the body. The inhibition is thought to originate in the brain, and is thought to affect both wide dynamic range and
88:
with a rubber top is used to apply pressure to a person's finger or toe. The pressure at which the first sensation of pain is felt is recorded as PPT. The pressure is increased further and noted when the person says the pain is intolerable. This higher value is recorded as PTol. A second noxious
102:
response is related to less pain, better physical functioning, and better self-rated health. Diabetic neuropathy patients with low DNIC are more likely to benefit from treatment with duloxetine and tapentadol, which are considered to restore altered descending modulation.
323:
Kashima K, Rahman OI, Sakoda S, Shiba R (October 1999). "Increased pain sensitivity of the upper extremities of TMD patients with myalgia to experimentally-evoked noxious stimulation: possibility of worsened endogenous opioid systems".
31:) refers to an endogenous pain modulatory pathway which has often been described as "pain inhibits pain". It occurs when response from a painful stimulus is inhibited by another, often spatially distant, noxious stimulus.
521:
Bannister K, Patel R, Goncalves L, Townson L, Dickenson AH (September 2015). "Diffuse noxious inhibitory controls and nerve injury: restoring an imbalance between descending monoamine inhibitions and facilitations".
279:
Yarnitsky D, Crispel Y, Eisenberg E, Granovsky Y, Ben-Nun A, Sprecher E, Best LA, Granot M (August 2008). "Prediction of chronic post-operative pain: pre-operative DNIC testing identifies patients at risk".
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stimulus (such as ice water) is then applied to a different part of the body and PPT/PTol measured. DNIC response is defined as an increase in the value of PPT during the second noxious stimulation.
394:
Edwards RR, Ness TJ, Weigent DA, Fillingim RB (December 2003). "Individual differences in diffuse noxious inhibitory controls (DNIC): association with clinical variables".
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Yarnitsky D, Granot M, Nahman-Averbuch H, Khamaisi M, Granovsky Y (June 2012). "Conditioned pain modulation predicts duloxetine efficacy in painful diabetic neuropathy".
236:
Popescu A, LeResche L, Truelove EL, Drangsholt MT (August 2010). "Gender differences in pain modulation by diffuse noxious inhibitory controls: a systematic review".
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Studies investigating gender differences in DNIC have shown mixed results with the effect dependent upon experimental methodology and measurement method.
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Le Bars D, Dickenson AH, Besson JM (June 1979). "Diffuse noxious inhibitory controls (DNIC). I. Effects on dorsal horn convergent neurones in the rat".
55:
59:
439:"Tapentadol potentiates descending pain inhibition in chronic pain patients with diabetic polyneuropathy"
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Lautenbacher S, Rollman GB (September 1997). "Possible deficiencies of pain modulation in fibromyalgia".
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Le Bars D (October 2002). "The whole body receptive field of dorsal horn multireceptive neurones".
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531:
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78:
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47:
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84:
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40:
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Niesters M, Proto PL, Aarts L, Sarton EY, Drewes AM, Dahan A (July 2014).
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81:(PTol) parameters are widely used as a measure of DNIC. Equipment such as
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438:
171:
51:
43:
58:
of spinal cord. DNIC refers to the mechanism by which dorsal horn
128:
97:The DNIC model is used frequently to quantify the
63:nociception-specific neurons in the dorsal horn.
326:Cranio: The Journal of Craniomandibular Practice
8:
145:
143:
454:
50:nerve fibers, which carry the signal to
39:Noxious stimuli activate the endings of
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195:Brain Research. Brain Research Reviews
7:
105:DNIC forms the basis for the use of
17:Diffuse noxious inhibitory controls
14:
373:10.1097/00002508-199709000-00003
536:10.1097/j.pain.0000000000000240
443:British Journal of Anaesthesia
338:10.1080/08869634.1999.11746100
1:
207:10.1016/S0165-0173(02)00186-8
361:The Clinical Journal of Pain
164:10.1016/0304-3959(79)90049-6
25:conditioned pain modulation
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492:10.1016/j.pain.2012.02.021
408:10.1016/j.pain.2003.09.005
294:10.1016/j.pain.2007.10.033
250:10.1016/j.pain.2010.05.013
99:central pain sensitization
60:wide dynamic range neurons
75:Pressure pain threshold
456:10.1093/bja/aeu056
124:Counterstimulation
70:Measurement method
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109:to reduce pain.
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119:Counterirritant
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107:counterirritant
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83:metal pressure
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37:
12:
11:
5:
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530:(9): 1803–11.
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315:
271:
228:
201:(1–3): 29–44.
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158:(3): 283–304.
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94:
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79:pain tolerance
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2:
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541:
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486:(6): 1193–8.
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457:
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449:(1): 148–56.
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402:(3): 427–37.
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367:(3): 189–96.
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244:(2): 309–18.
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332:(4): 241–6.
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93:Clinical use
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38:
28:
24:
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16:
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288:(1): 22–8.
56:dorsal horn
41:nociceptive
135:References
77:(PPT) and
85:algometer
35:Mechanism
565:Category
552:25554640
544:26010460
508:35752776
500:22480803
465:24713310
416:14659526
346:10650395
310:26513812
302:18079062
266:27476459
258:20557999
223:53186033
215:12589904
180:36191807
113:See also
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381:9303250
54:in the
52:neurons
48:A delta
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172:460935
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548:S2CID
504:S2CID
420:S2CID
306:S2CID
262:S2CID
219:S2CID
176:S2CID
23:) or
571:Pain
540:PMID
524:Pain
496:PMID
480:Pain
461:PMID
412:PMID
396:Pain
377:PMID
342:PMID
298:PMID
282:Pain
254:PMID
238:Pain
211:PMID
168:PMID
152:Pain
129:Pain
46:and
21:DNIC
532:doi
528:156
488:doi
484:153
451:doi
447:113
404:doi
400:106
369:doi
334:doi
290:doi
286:138
246:doi
242:150
203:doi
160:doi
29:CPM
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44:C
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19:(
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