137:
24:
296:
737:
Vaijayanthi, Thangavel; Bando, Toshikazu; Pandian, Ganesh N.; Sugiyama, Hiroshi (2012). "Progress and
Prospects of Pyrrole-Imidazole Polyamide-Fluorophore Conjugates as Sequence-Selective DNA Probes".
94:
702:
Baraldi, Pier
Giovanni; Preti, Delia; Fruttarolo, Francesca; Tabrizi, Mojgan Aghazadeh; Romagnoli, Romeo (2007). "Hybrid molecules between distamycin a and active moieties of antitumor agents".
201:
InChI=1S/C22H27N9O4/c1-29-9-13(26-12-32)6-17(29)21(34)28-15-8-18(31(3)11-15)22(35)27-14-7-16(30(2)10-14)20(33)25-5-4-19(23)24/h6-12H,4-5H2,1-3H3,(H3,23,24)(H,25,33)(H,26,32)(H,27,35)(H,28,34)
303:
217:
551:
Pagano, Bruno; Fotticchia, Iolanda; De Tito, Stefano; Mattia, Carlo A.; Mayol, Luciano; Novellino, Ettore; Randazzo, Antonio; Giancola, Concetta (2010).
602:
Majumder, Parijat; Banerjee, Amrita; Shandilya, Jayasha; Senapati, Parijat; Chatterjee, Snehajyoti; Kundu, Tapas K.; Dasgupta, Dipak (2013).
192:
796:
384:
407:
310:
40:
N-{5-carbamoyl}-1-methyl-1H-pyrrol-3-yl)carbamoyl]-1-methyl-1H-pyrrol-3-yl}-4-formamido-1-methyl-1H-pyrrole-2-carboxamide
169:
457:
Barrett, Michael P.; Gemmell, Curtis G.; Suckling, Colin J. (2013). "Minor groove binders as anti-infective agents".
663:"Mammalian topoisomerase II activity is modulated by the DNA minor groove binder distamycin in simian virus 40 DNA"
338:
376:
132:
367:
36:
791:
615:
505:
801:
60:
365:. As opposed to netropsin, distamycin contains three N-methyl-pyrrole units. It is harvested from
762:
806:
786:
754:
719:
684:
643:
584:
533:
474:
553:"Selective Binding of Distamycin a Derivative to G-Quadruplex Structure [d(TGGGGT)]4"
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that also produces netropsin. Distamycin prefers AT-rich DNA-sequences and tetrades of
287:
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125:
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Proceedings of the
National Academy of Sciences of the United States of America
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604:"Minor Groove Binder Distamycin Remodels Chromatin but Inhibits Transcription"
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494:"The molecular origin of DNA-drug specificity in netropsin and distamycin"
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Kopka, M. L.; Yoon, C.; Goodsell, D.; Pjura, P.; Dickerson, R. E. (1985).
23:
354:
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145:
286:
Except where otherwise noted, data are given for materials in their
93:
83:
434:
225:/N=C(/CCNC(=O)c1cc(cn1C)NC(=O)c2cc(cn2C)NC(=O)c3cc(cn3C)NC=O)\N
157:
452:
450:
410:is 37,000 M cm at a wavelength of 303 nm.
69:
8:
135:
113:
15:
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177:
383:. Derivates from distamycin are used as
446:
222:
197:
126:
337:, binding to the small furrow of the
204:Key: UPBAOYRENQEPJO-UHFFFAOYSA-N
48:Distamycin A, Herperetin, Stallimycin
7:
704:Bioorganic & Medicinal Chemistry
402:, and sensible to light, freeze and
667:The Journal of Biological Chemistry
148:
387:to combat tumours. Derivates with
379:and increases the activity of the
14:
471:10.1016/j.pharmthera.2013.03.002
385:alkylating antineoplastic agents
294:
22:
661:Fesen, M.; Pommier, Y. (1989).
459:Pharmacology & Therapeutics
290:(at 25 °C , 100 kPa).
1:
680:10.1016/S0021-9258(18)60471-5
408:molar attenuation coefficient
629:10.1371/journal.pone.0057693
357:antibiotic and analogous to
272:481.508 g/mol
828:
375:. Distamycin inhibits the
716:10.1016/j.bmc.2006.07.004
395:for double-stranded DNA.
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233:
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53:
45:
35:
30:
21:
557:Journal of Nucleic Acids
797:DNA-binding substances
751:10.1002/cbic.201200451
519:10.1073/pnas.82.5.1376
368:Streptomyces netropsis
620:2013PLoSO...857693M
570:10.4061/2010/247137
510:1985PNAS...82.1376K
335:minor groove binder
18:
333:, which acts as a
311:Infobox references
16:
745:(15): 2170–2185.
361:and the class of
319:Chemical compound
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95:Interactive image
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398:The compound is
393:fluorescent tags
381:topoisomerase II
349:Distamycin is a
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241:Chemical formula
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673:(19): 11354–9.
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614:(2): e57693.
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377:transcription
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280:White powder
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127:ECHA InfoCard
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710:(1): 17–35.
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465:(1): 12–23.
462:
458:
397:
391:are used as
389:fluorophores
366:
363:lexitropsins
348:
339:double helix
322:
321:
54:Identifiers
46:Other names
792:Antibiotics
739:ChemBioChem
420:Lexitropsin
400:hygroscopic
277:Appearance
234:Properties
133:100.026.823
17:Distamycin
802:Imidazoles
781:Categories
441:References
404:hydrolysis
345:Properties
331:antibiotic
323:Distamycin
268:Molar mass
179:F6010N240F
106:ChemSpider
82:3D model (
61:CAS Number
37:IUPAC name
425:Netropsin
359:netropsin
327:polyamide
71:6576-51-8
807:Pyrroles
787:Peptides
759:23023993
724:17081759
648:23460895
608:PLOS ONE
589:20725616
479:23507040
414:See also
159:24894001
767:1491900
689:2544590
639:3584068
616:Bibcode
580:2915651
563:: 1–7.
538:2983343
506:Bibcode
355:amidine
351:pyrrole
304:what is
302: (
262:
146:PubChem
812:Amines
765:
757:
722:
687:
646:
636:
587:
577:
536:
529:397264
526:
477:
406:. Its
218:SMILES
31:Names
763:S2CID
325:is a
193:InChI
84:JSmol
755:PMID
720:PMID
685:PMID
644:PMID
585:PMID
561:2010
534:PMID
475:PMID
435:DAPI
170:UNII
115:3003
747:doi
712:doi
675:doi
671:264
634:PMC
624:doi
575:PMC
565:doi
524:PMC
514:doi
467:doi
463:139
149:CID
783::
761:.
753:.
743:13
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708:15
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449:^
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252:27
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612:8
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567::
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508::
481:.
469::
373:4
353:-
329:-
300:N
260:4
258:O
256:9
254:N
250:H
246:C
86:)
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