233:, Segev and his team found that patients who received a kidney transplant from an incompatible live donor had a much higher survival benefit compared to patients who stayed on dialysis or waited for a deceased donor transplant. There are over 20,000 patients on the waitlist who have become highly sensitized, meaning that they have developed antibodies human leukocyte antigens—HLAs—key components of the immune system. These findings show that moving forward with a live donor kidney transplant could be the best option for highly sensitized patients who have a healthy and willing donor.
267:
mind, Segev and
Boyarsky looked at both the Nationwide Inpatient Sample to study in-hospital deaths of HIV+ patients and the HIV Research Network, which provided granular disease-specific data, to calculate the impact of using organs from HIV+ donors on the organ transplant waitlist. Both data sources allowed Segev and Boyarsky to estimate a possible 500 to 600 HIV+ donors in the United States, whose organs were currently being discarded.
248:
limited kidney-transplant patients and their families to connect with other incompatible pairs on their own. Together, Segev and Gentry devised a nationwide system to match donor-patient pairs. Based on an algorithm created by the
Canadian mathematician Jack Edmonds in 1965, the system improves paired donation by ensuring the maximum number of matches while still factoring in age, location and willingness to travel.
33:
282:, Segev and his mentee visited every major national transplant and AIDS advocacy group in the US. Within weeks, they had every group officially supporting their campaign to legalize using organs from HIV+ donors for HIV+ recipients. In August 2011, Segev and Boyarsky sought out bipartisan support to change the existing law. California Senator
310:
With the HOPE Act, HIV positive patients on the current kidney and liver waiting lists can elect to also be open to any organs whose donors were diagnosed with HIV. This would not remove the patients from accepting non-HIV positive organs. However, it does have the potential to significantly shorten
247:
The first kidney-paired donation was performed in South Korea in 1991, followed by one in Europe in 1999. Sommer Gentry and Dorry Segev found that the existing matching programs were not sufficient to accommodate the scale of the transplant waitlist in the United States. Previous matching programs
426:
Robert A. Montgomery, Bonnie E. Lonze, Karen E. King, Edward S. Kraus, D., Lauren M. Kucirka, Jayme E. Locke, Daniel S. Warren, Christopher E. Simpkins, Nabil N. Dagher, Andrew L. Singer, Andrea A. Zachary, and Dorry L. Segev, "Desensitization in HLA-incompatible kidney recipients and survival".
266:
In May 2010, Brian
Boyarsky sought out Segev's advice after doing previous research comparing transplant programs in different countries. During his research, Boyarsky met Elmi Muller, who had been successfully transplanting organs between HIV+ donors and recipients in South Africa. With that in
226:
There are over 20,000 patients on the kidney transplant waitlist who have become highly sensitized, making finding a compatible donor extremely difficult. These patients often spend years on the kidney transplant waitlist looking for a compatible donor. In a 2016 study published in
418:
Dorry L. Segev, MD, PhD; Abimereki D. Muzaale, ; Brian S. Caffo,; Shruti H. Mehta, Andrew L. Singer, Sarah E. Taranto; Maureen A. McBride, Robert A. Montgomery. "Perioperative
Mortality and Long-term Survival Following Live Kidney Donation"
716:
2007, Taoti
Enterprises International | Web Design and Marketing | www.taoti.com - August. "Compatible Pairs - National Kidney Registry - Facilitating Living Donor Transplants". kidneyregistry.org. Retrieved
262:
Before 2013, it was illegal to use organs from HIV+ donors for transplantation. Any organ whose donor was diagnosed with HIV would be immediately thrown out, despite them being otherwise healthy organs.
1254:
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1259:
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835:
Boyarsky BJ, Hall EC, Singer AL, et al. Estimating the potential pool of HIV-infected deceased organ donors in the United States. Am J Transplant 2011; 11:1209–1217.
404:, Purvi Patel, a, Ryan Takenaga, Lara Devgan, Christine G. Holzmueller, Jing Tian, Linda P. Fried,. "Frailty as a predictor of surgical outcomes in older patients".
726:
Ellison, Blake (2014-05-16). "A Systematic Review of Kidney Paired
Donation: Applying Lessons From Historic and Contemporary Case Studies to Improve the US Model".
185:
141:
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448:
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322:
Segev married Sommer Gentry on
October 18, 2003, in Ventura, California. They now both reside in New York City. Gentry is a full professor at the
1179:
148:. He has made significant contributions to the field of transplantation, including developing a mathematical model to facilitate a nationwide
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593:
278:
229:
251:
Under the direction of Segev and Robert
Montgomery, Johns Hopkins completed the first five-way donor kidney swap among 10 individuals.
1207:
290:(R) became the main sponsors of the bill first drafted by Segev and Boyarsky. They were later joined by congressional representatives
703:
Hub staff report (November 2, 2017). "Hopkins study demonstrates survival benefits of incompatible living donor kidney transplants".
133:
929:
1234:
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Redfern, Suz. "Dorry Segev, Extreme
Renaissance Man". Dorry Segev, Extreme Renaissance Man. 12 Apr. 2015. Web. April 14, 2016.
1229:
565:
1058:
857:
Colfax, Grant, MD. "HIV Organ Policy Equity (HOPE) Act Is Now Law". The White House, November 21, 2013. Web. April 14, 2016.
411:
Segev, DL, Gentry SE, Warren DS, Reeb B, Montgomery RA. Kidney Paired
Donation and optimizing the use of live donor organs.
778:
Pitts; Louszko; Cappetta; Effron; Valiente (15 Apr 2015). "Changing Lives Through Donating Kidneys to Strangers". ABC News
822:
Boyarsky, Brian and Dorry L. Segev. "From Bench to Bill: How a Transplant Nuance Became 1 of Only 57 Laws Passed in 2013"
341:, that is dedicated to introducing the art of swing dance to non-dancers. Charm City Swing found a permanent home at the
1095:
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153:
470:
314:
The first HIV-to-HIV transplants in the United States were performed on March 30, 2016, at Johns Hopkins University.
1117:
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Christensen, Jen. "First Liver Transplant between HIV-positive Patients". CNN. March 31, 2016. Web. April 14, 2016.
690:
Orandi, Babak J, and Dorry L Segeb. "Survival Benefit with Kidney Transplants from HLA-Incompatible Live Donors".
669:
1180:"Hot topics in kidney transplantation by Dr. Dorry Segev – Paradigm 5: Kidney exchange beyond incompatibilities"
244:
is a form of live donation where patients with incompatible donors swap kidneys to receive a compatible kidney.
295:
218:
Segev is the director of the Epidemiology Research Group in Organ Transplantation at Johns Hopkins University.
177:
113:
55:
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866:"HIV-to-HIV Transplant Media Briefing". YouTube. Johns Hopkins Medicine, March 31, 2016. Web. April 14, 2016.
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The HIV Organ Policy Equity Act (or HOPE Act) was introduced in the Senate on February 14, 2013.
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449:"A Problem-Solver Extraordinaire Explains How He Became a Leading Expert in Transplant Medicine"
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with Gentry. In 2005, Segev and Gentry started Charm City Swing, a non-profit organization in
193:
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169:
1053:
Emamaullee, Juliet E., MD. "Profiles in Surgical Research: Dorry L. Segev, MD, PhD, FACS".
655:
Victor, Daniel. "Johns Hopkins to Perform First H.I.V.-Positive Organ Transplants in U.S."
1157:
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The longest kidney-pair chain to date included 70 participants and was completed in 2014.
205:
173:
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http://bulletin.facs.org/2015/07/profiles-in-surgical-research-dorry-l-segev-md-phd-facs/
754:
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132:. Previously he served as the Marjory K. and Thomas Pozefsky Professor of Surgery at
1218:
743:, September 4, 2005, content.time.com/time/subscriber/article/0,33009,1101302,00.html
283:
181:
86:
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Hamilton, A. (2005). Calculating Change: The Kidney Connection: Math Makes a Match.
1131:
https://www.the-asci.org/core/controllers/asci/AsciProfileController.php?pid=500943
844:
Belluck, Pam. "A New Push to Let H.I.V. Patients Accept Organs That Are Infected".
137:
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Hamilton, Anita. "Calculating Change: The Kidney Connection: Math Makes a Match".
176:
in 1992. He obtained his M.D. at Johns Hopkins University in 1996, as well as his
363:
2009 - Julius Jacobson Promising Investigator Award, American College of Surgeons
152:
program, both in the US and Canada. He is also known for his role in getting the
1118:
http://asts.org/grants-and-research/recognition-awards/award-recipients/previous
707:, 9 Mar. 2016, hub.jhu.edu/2016/03/09/incompatible-kidney-transplants-survival/.
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2022 - Kidney exchange beyond incompatibilities by Dr. Dorry Segev – Paradigm 5
32:
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2008 - Clinical Scientist Development Award, Doris Duke Charitable Foundation
794:"President Signs HOPE Act, Clearing the Way for HIV Positive Organ Donation"
366:
2009 - John Merrill Award in Transplantation, American Society of Nephrology
334:
497:
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is the head of the Center for Surgical and Transplant Applied Research at
408:
210.6 (2010): 901-908. Cited by 568 articles, according to Google Scholar
369:
2009 - Jocabson Promising Investigator Award, American College of Surgeons
930:"'Genius' pair rewrite rules of organ transplants, among other interests"
907:
311:
a patient's wait time on the kidney and liver deceased donor wait list.
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https://www.asn-online.org/grants/career/recipients.aspx?app=MERRILL
1033:"2013 Clinical Research Mentorship Grantees | Grant Recipients"
644:
http://content.time.com/time/magazine/article/0,9171,1101302,00.html
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2007 - Dennis W Jahnigen Scholars Award, American Geriatrics Society
400:
Makary, Martin A., Dorry L. Segev, Peter J. Pronovost, Dora Syin,
984:
997:
755:"Hopkins Surgical Teams Perform Historic Quintuple Kidney Swap"
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Lindy Hop and Swing Dance in Baltimore and Worldwide. (n.d.).
566:"Profiles in surgical research: Dorry L. Segev, MD, PhD, FACS"
354:
2006 - Vanguard Prize, American Society of Transplant Surgeons
326:
and contributes to multiple research projects in Segev's lab.
191:
Both Segev and his wife, Sommer Gentry, have been featured in
387:
2017 - Distinguished Alumnus Award, Johns Hopkins University
375:
2012 - Inducted, American Society for Clinical Investigation
848:, April 10, 2011, www.nytimes.com/2011/04/11/us/11hiv.html.
144:, and associate vice chair of the Department of Surgery at
694:, March 10, 2016, pp. 940–950., doi:10.1056/NEJMoa1508380.
423:
2101 March 10; 303 (10) 959-966 Cited by 365 articles, r
298:(R) to support the bill in the House of Representatives.
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ASCI - The American Society for Clinical Investigation.
886:
415:. 2005 Apr 20; 293 (15) 1883-90. Cited by 295 articles,
1255:
Johns Hopkins Bloomberg School of Public Health alumni
910:. Epidemiology Research Group in Organ Transplantation
670:"Epidemiology Research Group in Organ Transplantation"
500:. Epidemiology Research Group in Organ Transplantation
951:"Naval Academy Faculty Receive Promotions and Tenure"
258:
HOPE Act and HIV positive transplantation in the U.S.
1035:. Doris Duke Charitable Foundation. January 6, 2013
307:signed the HOPE Act into law on November 21, 2013.
109:
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82:
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571:The Bulletin of the American College of Surgeons
521:"Dorry Segev, M.D., Ph.D., Professor of Surgery"
186:Johns Hopkins Bloomberg School of Public Health
142:Johns Hopkins Bloomberg School of Public Health
431:365.4 (2011): 318-326. Cited by 309 articles,
8:
1245:Members of the National Academy of Medicine
471:"Simple test for kidney transplant outcome"
406:Journal of the American College of Surgeons
31:
20:
1116:"Previous Grants and Awards Recipients".
1260:Johns Hopkins School of Medicine faculty
469:By Jpost.Com Staff (February 21, 2012).
276:and Boyarsky's article appearing in the
1250:Johns Hopkins School of Medicine alumni
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184:and Ph.D. in clinical investigation at
1022:. 25 June 2007. Retrieved 4 Apr. 2008.
826:Volume 263(3). (2016): 430-433. Print.
659:, 2016. Web. Retrieved April 14, 2016.
628:: CS1 maint: archived copy as title (
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270:After appearing on the front page of
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692:The New England Journal of Medicine
372:2012 - ASTS Mid-Level Faculty Grant
279:American Journal of Transplantation
230:The New England Journal of Medicine
1160:. Johns Hopkins Alumni Association
1158:"Distinguished Alumnus Award 2017"
1070:"Grants & Funding". ASN News.
792:Rhodan, Maya (November 22, 2013).
14:
728:Wharton Research Scholars Journal
753:Vohr, Eric (November 27, 2006).
134:Johns Hopkins School of Medicine
429:New England Journal of Medicine
156:(or HOPE Act) signed into law.
1208:"User profile for Dorry Segev"
985:http://www.dorryandsommer.com/
222:Incompatible kidney transplant
1:
378:2016 - Global Thinker Award,
1240:American transplant surgeons
1096:American College of Surgeons
730:. 107. Retrieved 2016-08-23.
154:HIV Organ Policy Equity Act
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1120:. Retrieved April 7, 2016.
1092:"Jacobson Past Recipients"
1081:. Retrieved April 7, 2016.
1061:. Retrieved April 7, 2016.
1018:"For the Record: Cheers".
987:. Retrieved April 7, 2016.
949:Unknown (April 20, 2016).
887:"Dorry and Sommer Wedding"
646:. Retrieved April 7, 2016.
78:HIV-to-HIV Transplantation
286:(D) and Oklahoma Senator
164:Segev earned his B.S. in
119:
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672:. Johns Hopkins Medicine
546:. Johns Hopkins Medicine
523:. Johns Hopkins Medicine
114:Johns Hopkins University
56:Johns Hopkins University
395:Most-cited publications
1235:Rice University alumni
1144:"Global Thinkers 2016"
305:President Barack Obama
242:Kidney paired donation
237:Kidney paired donation
166:electrical engineering
150:kidney paired donation
146:Johns Hopkins Hospital
67:Kidney transplantation
1230:Physicians from Haifa
1077:June 4, 2015, at the
1020:Johns Hopkins Gazette
908:"Faculty & Staff"
759:Johns Hopkins Gazette
498:"Faculty & Staff"
160:Education and career
610:on November 7, 2017
402:Karen Bandeen-Roche
339:Baltimore, Maryland
1000:. Mobtown Ballroom
846:The New York Times
657:The New York Times
544:"Transplant Titan"
476:The Jerusalem Post
273:The New York Times
212:The New York Times
130:NYU Langone Health
104:Transplant surgery
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349:Honors and awards
194:The Baltimore Sun
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955:The Trident
803:October 29,
764:October 29,
717:2016-08-26.
614:January 17,
331:swing dance
296:Andy Harris
25:Dorry Segev
1219:Categories
436:References
292:Lois Capps
288:Tom Coburn
71:Nephrology
39:Web Summit
1164:March 25,
1102:March 25,
1039:March 25,
1004:March 25,
960:March 25,
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892:March 25,
780:Nightline
676:March 25,
578:March 25,
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527:March 25,
504:March 25,
482:March 25,
454:August 8,
345:in 2012.
335:Lindy Hop
188:in 2009.
1075:Archived
624:cite web
384:magazine
294:(D) and
705:The Hub
200:Science
41:in 2021
998:"Home"
209:, and
178:M.H.S.
100:Fields
83:Spouse
608:(PDF)
597:(PDF)
1188:2022
1166:2020
1104:2020
1041:2020
1006:2020
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894:2020
805:2021
798:Time
766:2021
741:Time
678:2020
630:link
616:2022
580:2020
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529:2020
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456:2024
421:JAMA
413:JAMA
333:and
206:Time
180:in
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