20:
2831:
119:
and the eIF4G scaffold, connecting the mRNA 5' terminus to a hub of other initiation factors and mRNA. The interaction of eIF4G•A is thought to guide the formation of a single-stranded RNA landing pad for the
2118:
68:. The mammalian eIF4F complex was first described in 1983, and has been a major area of study into the molecular mechanisms of cap-dependent translation initiation ever since.
1769:
100:
Structures of eIF4F components have been solved individually and as partial complexes by a variety of methods, but no complete structure of eIF4F is currently available.
1593:
1180:
92:
translation initiation; for instance, certain viral proteases cleave eIF4G to remove the eIF4E-binding region, thus inhibiting cap-dependent translation.
2148:
793:
108:
In mammals, the eIF4E•G•A trimeric complex can be directly purified from cells, while only the two subunit eIF4E•G can be purified from yeast cells.
2158:
1895:
77:
2195:
2191:
961:
370:
Gross, John D.; Moerke, Nathan J.; von der Haar, Tobias; Lugovskoy, Alexey A.; Sachs, Alan B.; McCarthy, John E.G.; Wagner, Gerhard (2003).
331:. Phosphorylation of 4E-BPs by mTOR prevents their binding to eIF4E, freeing eIF4E to bind eIF4G and participate in translation initiation.
2570:
2565:
2560:
2555:
2545:
2525:
2520:
2510:
2500:
2480:
2475:
2470:
2460:
2455:
2450:
2445:
2435:
2425:
2420:
2415:
2410:
2187:
2380:
2375:
2365:
1248:
845:
825:
1173:
933:
299:
In addition to the major proteins encompassing the eIF4F trimer, the eIF4F complex functionally interacts with proteins including
2138:
2133:
2128:
1243:
1238:
1087:
1031:
1953:
1026:
2866:
2851:
1114:
1045:
786:
2821:
2550:
2540:
2535:
2530:
2515:
2505:
2495:
2490:
2485:
2465:
2440:
2430:
2405:
2400:
2395:
2390:
2385:
2370:
1319:
1166:
850:
345:
1286:
1230:
1158:
131:
The eIF4F proteins interact with a number of different binding partners, and there are multiple genetic isoforms of
2861:
2316:
2256:
2103:
2093:
2083:
2043:
2023:
1998:
1973:
1948:
1065:
1309:
1304:
1299:
1294:
2784:
2331:
2326:
2321:
2311:
2306:
2301:
2296:
2291:
2286:
2281:
2276:
2271:
2266:
2261:
2251:
2246:
2241:
2236:
2231:
2226:
2181:
2123:
2113:
2108:
2098:
2088:
2078:
2073:
2068:
2063:
2058:
2053:
2048:
2038:
2033:
2028:
2018:
2013:
2008:
2003:
1993:
1988:
1983:
1978:
1968:
1963:
1958:
1943:
1928:
121:
2856:
2808:
2221:
2216:
2211:
2201:
2176:
2171:
1938:
1933:
1923:
1918:
1913:
1908:
1903:
1109:
897:
810:
779:
2804:
1070:
887:
872:
281:
156:
2350:
1205:
1075:
1000:
892:
340:
89:
85:
47:
1197:
1193:
990:
975:
855:
19:
2206:
2166:
1201:
1189:
1097:
995:
913:
680:
419:
Aitken CE, Lorsch JR (June 2012). "A mechanistic overview of translation initiation in eukaryotes".
1731:
923:
1058:
941:
724:
Low WK, Dang Y, Schneider-Poetsch T, Shi Z, Choi NS, Merrick WC, Romo D, Liu JO (December 2005).
444:
372:"Ribosome Loading onto the mRNA Cap Is Driven by Conformational Coupling between eIF4G and eIF4E"
1877:
1694:
1221:
1142:
747:
706:
649:
600:
559:
510:
436:
401:
393:
113:
669:"Rocaglates convert DEAD-box protein eIF4A into a sequence-selective translational repressor"
2751:
2741:
2736:
2726:
2716:
2696:
2681:
2676:
2671:
2656:
2651:
2646:
2631:
1779:
737:
696:
688:
639:
631:
590:
549:
541:
500:
490:
428:
383:
2621:
2601:
2596:
2586:
1276:
1266:
726:"Inhibition of eukaryotic translation initiation by the marine natural product pateamine A"
1119:
956:
802:
35:
684:
2835:
1839:
946:
918:
701:
668:
644:
619:
554:
529:
505:
478:
350:
116:
39:
23:
Solution structure of yeast eIF4E bound to the m7G cap and a eIF4G fragment (PDB 1RF8).
595:
578:
388:
371:
2845:
2789:
1147:
834:
213:
43:
1391:
1258:
1021:
951:
820:
448:
125:
54:
635:
143:
in the human genome. In mammals, eIF4F is bridged to the 40S ribosomal subunit by
742:
725:
545:
2794:
1124:
1053:
217:
2830:
620:"Hippuristanol - A potent steroid inhibitor of eukaryotic initiation factor 4A"
50:
initiation. The eIF4F complex is composed of three non-identical subunits: the
2799:
1082:
397:
1886:
495:
751:
710:
653:
563:
514:
440:
405:
81:
604:
1801:
1796:
1791:
1102:
1092:
1016:
328:
255:
251:
247:
51:
692:
1522:
838:
311:
or DAP5, also appears to perform a non-canonical translation function.
88:
translation initiation. Components of the complex are also involved in
579:"Circularization of mRNA by eukaryotic translation initiation factors"
432:
2756:
2746:
2731:
2721:
2711:
2706:
2701:
2691:
2686:
2666:
2661:
2641:
2636:
1813:
1786:
1774:
1647:
1603:
1598:
1581:
1576:
1564:
1559:
1554:
1487:
1438:
1433:
1428:
1423:
1418:
1403:
1398:
1386:
1362:
1357:
530:"Quantitative studies of mRNA recruitment to the eukaryotic ribosome"
324:
308:
275:
271:
241:
237:
233:
195:
191:
187:
2626:
2616:
2611:
2606:
2591:
2336:
2143:
1865:
1860:
1818:
1808:
1764:
1716:
1711:
1654:
1642:
1615:
1610:
1588:
1571:
1549:
1527:
1517:
1512:
1507:
1502:
1497:
1492:
1482:
1477:
1472:
1467:
1413:
1408:
1345:
1271:
860:
771:
320:
304:
300:
263:
225:
209:
205:
201:
179:
152:
151:, while budding yeast lacks this connection. Interactions between
148:
140:
136:
132:
109:
65:
61:
57:
1850:
1825:
1746:
1741:
1736:
1726:
1721:
1676:
1666:
1637:
1627:
1539:
1457:
1445:
1376:
1350:
1340:
1330:
144:
1162:
775:
830:
159:
are thought to mediate the circularization of mRNA particles.
2819:
577:
Wells SE, Hillner PE, Vale RD, Sachs AB (July 1998).
2777:
2579:
2358:
2349:
2157:
1894:
1885:
1876:
1838:
1755:
1702:
1693:
1663:
1624:
1536:
1454:
1373:
1327:
1318:
1285:
1257:
1229:
1220:
1213:
1135:
1044:
1009:
983:
974:
932:
906:
880:
871:
809:
280:"Scaffold" protein. Binds mRNA, eIF4A, eIF4E, and
296:Approximate molecular weight for human proteins.
1174:
787:
667:Iwasaki S, Floor SN, Ingolia NT (June 2016).
8:
16:Multiprotein complex used in gene expression
323:subunit of eIF4F is an important target of
2355:
1891:
1882:
1699:
1324:
1226:
1217:
1181:
1167:
1159:
980:
942:Precursor mRNA (pre-mRNA / hnRNA)
877:
794:
780:
772:
200:DEAD-box RNA helicase. Binds mRNA, eIF4G,
741:
700:
643:
594:
553:
504:
494:
472:
470:
468:
466:
464:
462:
460:
458:
421:Nature Structural & Molecular Biology
387:
161:
18:
2826:
362:
618:Cencic R, Pelletier J (January 2016).
76:eIF4F is important for recruiting the
962:Histone acetylation and deacetylation
7:
1027:Ribosome-nascent chain complex (RNC)
483:The Journal of Biological Chemistry
212:. Inhibited by the small molecules
64:, and the large "scaffold" protein
291:
246:Cap-binding protein. Binds eIF4G,
14:
2829:
307:. The unusual isoform of eIF4G,
1032:Post-translational modification
28:Eukaryotic initiation factor 4F
1:
636:10.1080/21690731.2015.1137381
596:10.1016/S1097-2765(00)80122-7
389:10.1016/s0092-8674(03)00975-9
329:eIF4E binding protein (4E-BP)
78:small ribosomal subunit (40S)
743:10.1016/j.molcel.2005.10.008
546:10.1016/j.biochi.2015.02.017
346:Eukaryotic initiation factor
477:Merrick WC (October 2015).
382:(6). Elsevier BV: 739–750.
2883:
60:, the cap-binding protein
2785:Aminoacyl tRNA synthetase
220:(RocA), and pateamine A.
122:43S preinitiation complex
2809:Kozak consensus sequence
1093:sequestration (P-bodies)
479:"eIF4F: a retrospective"
2805:Shine-Dalgarno sequence
1071:Gene regulatory network
528:Fraser CS (July 2015).
496:10.1074/jbc.R115.675280
1076:cis-regulatory element
341:Eukaryotic translation
327:signaling through the
124:(43S PIC) via eIF4A's
48:eukaryotic translation
44:messenger RNAs (mRNAs)
34:) is a heterotrimeric
24:
22:
2867:RNA-binding proteins
2852:Protein biosynthesis
1705:Mitochondrial
1190:Protein biosynthesis
1098:alternative splicing
1088:Post-transcriptional
914:Transcription factor
1022:Transfer RNA (tRNA)
693:10.1038/nature17978
685:2016Natur.534..558I
1878:Ribosomal Proteins
1136:Influential people
1115:Post-translational
934:Post-transcription
25:
2862:Protein complexes
2817:
2816:
2773:
2772:
2769:
2768:
2765:
2764:
2345:
2344:
1834:
1833:
1758:Eukaryotic
1695:Elongation factor
1689:
1688:
1685:
1684:
1222:Initiation factor
1156:
1155:
1040:
1039:
970:
969:
846:Special transfers
433:10.1038/nsmb.2303
288:
287:
2874:
2834:
2833:
2825:
2356:
1892:
1883:
1757:
1704:
1700:
1670:
1631:
1543:
1461:
1380:
1334:
1325:
1227:
1218:
1183:
1176:
1169:
1160:
981:
878:
796:
789:
782:
773:
756:
755:
745:
721:
715:
714:
704:
679:(7608): 558–61.
664:
658:
657:
647:
615:
609:
608:
598:
574:
568:
567:
557:
525:
519:
518:
508:
498:
474:
453:
452:
416:
410:
409:
391:
367:
295:
162:
84:of mRNAs during
2882:
2881:
2877:
2876:
2875:
2873:
2872:
2871:
2857:Gene expression
2842:
2841:
2840:
2828:
2820:
2818:
2813:
2761:
2575:
2341:
2153:
1872:
1830:
1751:
1681:
1664:
1659:
1625:
1620:
1537:
1532:
1455:
1450:
1374:
1369:
1328:
1314:
1281:
1253:
1209:
1187:
1157:
1152:
1131:
1066:Transcriptional
1036:
1005:
966:
957:Polyadenylation
928:
902:
867:
861:Protein→Protein
812:
805:
803:Gene expression
800:
760:
759:
723:
722:
718:
666:
665:
661:
630:(1): e1137381.
617:
616:
612:
576:
575:
571:
527:
526:
522:
489:(40): 24091–9.
476:
475:
456:
418:
417:
413:
369:
368:
364:
359:
337:
317:
290:
106:
98:
90:cap-independent
74:
38:that binds the
36:protein complex
17:
12:
11:
5:
2880:
2878:
2870:
2869:
2864:
2859:
2854:
2844:
2843:
2839:
2838:
2815:
2814:
2812:
2811:
2802:
2797:
2792:
2787:
2781:
2779:
2778:Other concepts
2775:
2774:
2771:
2770:
2767:
2766:
2763:
2762:
2760:
2759:
2754:
2749:
2744:
2739:
2734:
2729:
2724:
2719:
2714:
2709:
2704:
2699:
2694:
2689:
2684:
2679:
2674:
2669:
2664:
2659:
2654:
2649:
2644:
2639:
2634:
2629:
2624:
2619:
2614:
2609:
2604:
2599:
2594:
2589:
2583:
2581:
2577:
2576:
2574:
2573:
2568:
2563:
2558:
2553:
2548:
2543:
2538:
2533:
2528:
2523:
2518:
2513:
2508:
2503:
2498:
2493:
2488:
2483:
2478:
2473:
2468:
2463:
2458:
2453:
2448:
2443:
2438:
2433:
2428:
2423:
2418:
2413:
2408:
2403:
2398:
2393:
2388:
2383:
2378:
2373:
2368:
2362:
2360:
2353:
2347:
2346:
2343:
2342:
2340:
2339:
2334:
2329:
2324:
2319:
2314:
2309:
2304:
2299:
2294:
2289:
2284:
2279:
2274:
2269:
2264:
2259:
2254:
2249:
2244:
2239:
2234:
2229:
2224:
2219:
2214:
2209:
2204:
2199:
2184:
2179:
2174:
2169:
2163:
2161:
2155:
2154:
2152:
2151:
2146:
2141:
2136:
2131:
2126:
2121:
2116:
2111:
2106:
2101:
2096:
2091:
2086:
2081:
2076:
2071:
2066:
2061:
2056:
2051:
2046:
2041:
2036:
2031:
2026:
2021:
2016:
2011:
2006:
2001:
1996:
1991:
1986:
1981:
1976:
1971:
1966:
1961:
1956:
1951:
1946:
1941:
1936:
1931:
1926:
1921:
1916:
1911:
1906:
1900:
1898:
1889:
1880:
1874:
1873:
1871:
1870:
1869:
1868:
1863:
1855:
1854:
1853:
1844:
1842:
1840:Release factor
1836:
1835:
1832:
1831:
1829:
1828:
1823:
1822:
1821:
1816:
1811:
1806:
1805:
1804:
1799:
1794:
1784:
1783:
1782:
1777:
1761:
1759:
1753:
1752:
1750:
1749:
1744:
1739:
1734:
1729:
1724:
1719:
1714:
1708:
1706:
1697:
1691:
1690:
1687:
1686:
1683:
1682:
1680:
1679:
1673:
1671:
1661:
1660:
1658:
1657:
1652:
1651:
1650:
1640:
1634:
1632:
1622:
1621:
1619:
1618:
1613:
1608:
1607:
1606:
1601:
1596:
1586:
1585:
1584:
1579:
1569:
1568:
1567:
1562:
1557:
1546:
1544:
1534:
1533:
1531:
1530:
1525:
1520:
1515:
1510:
1505:
1500:
1495:
1490:
1485:
1480:
1475:
1470:
1464:
1462:
1452:
1451:
1449:
1448:
1443:
1442:
1441:
1436:
1431:
1426:
1421:
1411:
1406:
1401:
1396:
1395:
1394:
1383:
1381:
1371:
1370:
1368:
1367:
1366:
1365:
1355:
1354:
1353:
1348:
1337:
1335:
1322:
1316:
1315:
1313:
1312:
1307:
1302:
1297:
1291:
1289:
1283:
1282:
1280:
1279:
1274:
1269:
1263:
1261:
1255:
1254:
1252:
1251:
1246:
1241:
1235:
1233:
1224:
1215:
1211:
1210:
1188:
1186:
1185:
1178:
1171:
1163:
1154:
1153:
1151:
1150:
1145:
1143:François Jacob
1139:
1137:
1133:
1132:
1130:
1129:
1128:
1127:
1122:
1112:
1107:
1106:
1105:
1100:
1095:
1085:
1080:
1079:
1078:
1073:
1063:
1062:
1061:
1050:
1048:
1042:
1041:
1038:
1037:
1035:
1034:
1029:
1024:
1019:
1013:
1011:
1007:
1006:
1004:
1003:
998:
993:
987:
985:
978:
972:
971:
968:
967:
965:
964:
959:
954:
949:
944:
938:
936:
930:
929:
927:
926:
921:
919:RNA polymerase
916:
910:
908:
904:
903:
901:
900:
895:
890:
884:
882:
875:
869:
868:
866:
865:
864:
863:
858:
853:
843:
842:
841:
823:
817:
815:
807:
806:
801:
799:
798:
791:
784:
776:
770:
769:
767:
765:
763:
758:
757:
730:Molecular Cell
716:
659:
610:
583:Molecular Cell
569:
520:
454:
411:
361:
360:
358:
355:
354:
353:
348:
343:
336:
333:
316:
313:
286:
285:
278:
269:
266:
260:
259:
244:
231:
228:
222:
221:
198:
185:
182:
176:
175:
172:
169:
166:
105:
102:
97:
94:
73:
70:
15:
13:
10:
9:
6:
4:
3:
2:
2879:
2868:
2865:
2863:
2860:
2858:
2855:
2853:
2850:
2849:
2847:
2837:
2832:
2827:
2823:
2810:
2806:
2803:
2801:
2798:
2796:
2793:
2791:
2790:Reading frame
2788:
2786:
2783:
2782:
2780:
2776:
2758:
2755:
2753:
2750:
2748:
2745:
2743:
2740:
2738:
2735:
2733:
2730:
2728:
2725:
2723:
2720:
2718:
2715:
2713:
2710:
2708:
2705:
2703:
2700:
2698:
2695:
2693:
2690:
2688:
2685:
2683:
2680:
2678:
2675:
2673:
2670:
2668:
2665:
2663:
2660:
2658:
2655:
2653:
2650:
2648:
2645:
2643:
2640:
2638:
2635:
2633:
2630:
2628:
2625:
2623:
2620:
2618:
2615:
2613:
2610:
2608:
2605:
2603:
2600:
2598:
2595:
2593:
2590:
2588:
2585:
2584:
2582:
2578:
2572:
2569:
2567:
2564:
2562:
2559:
2557:
2554:
2552:
2549:
2547:
2544:
2542:
2539:
2537:
2534:
2532:
2529:
2527:
2524:
2522:
2519:
2517:
2514:
2512:
2509:
2507:
2504:
2502:
2499:
2497:
2494:
2492:
2489:
2487:
2484:
2482:
2479:
2477:
2474:
2472:
2469:
2467:
2464:
2462:
2459:
2457:
2454:
2452:
2449:
2447:
2444:
2442:
2439:
2437:
2434:
2432:
2429:
2427:
2424:
2422:
2419:
2417:
2414:
2412:
2409:
2407:
2404:
2402:
2399:
2397:
2394:
2392:
2389:
2387:
2384:
2382:
2379:
2377:
2374:
2372:
2369:
2367:
2364:
2363:
2361:
2357:
2354:
2352:
2351:Mitochondrial
2348:
2338:
2335:
2333:
2330:
2328:
2325:
2323:
2320:
2318:
2315:
2313:
2310:
2308:
2305:
2303:
2300:
2298:
2295:
2293:
2290:
2288:
2285:
2283:
2280:
2278:
2275:
2273:
2270:
2268:
2265:
2263:
2260:
2258:
2255:
2253:
2250:
2248:
2245:
2243:
2240:
2238:
2235:
2233:
2230:
2228:
2225:
2223:
2220:
2218:
2215:
2213:
2210:
2208:
2205:
2203:
2200:
2197:
2193:
2189:
2185:
2183:
2180:
2178:
2175:
2173:
2170:
2168:
2165:
2164:
2162:
2160:
2156:
2150:
2147:
2145:
2142:
2140:
2137:
2135:
2132:
2130:
2127:
2125:
2122:
2120:
2117:
2115:
2112:
2110:
2107:
2105:
2102:
2100:
2097:
2095:
2092:
2090:
2087:
2085:
2082:
2080:
2077:
2075:
2072:
2070:
2067:
2065:
2062:
2060:
2057:
2055:
2052:
2050:
2047:
2045:
2042:
2040:
2037:
2035:
2032:
2030:
2027:
2025:
2022:
2020:
2017:
2015:
2012:
2010:
2007:
2005:
2002:
2000:
1997:
1995:
1992:
1990:
1987:
1985:
1982:
1980:
1977:
1975:
1972:
1970:
1967:
1965:
1962:
1960:
1957:
1955:
1952:
1950:
1947:
1945:
1942:
1940:
1937:
1935:
1932:
1930:
1927:
1925:
1922:
1920:
1917:
1915:
1912:
1910:
1907:
1905:
1902:
1901:
1899:
1897:
1893:
1890:
1888:
1884:
1881:
1879:
1875:
1867:
1864:
1862:
1859:
1858:
1856:
1852:
1849:
1848:
1846:
1845:
1843:
1841:
1837:
1827:
1824:
1820:
1817:
1815:
1812:
1810:
1807:
1803:
1800:
1798:
1795:
1793:
1790:
1789:
1788:
1785:
1781:
1778:
1776:
1773:
1772:
1771:
1768:
1767:
1766:
1763:
1762:
1760:
1754:
1748:
1745:
1743:
1740:
1738:
1735:
1733:
1730:
1728:
1725:
1723:
1720:
1718:
1715:
1713:
1710:
1709:
1707:
1701:
1698:
1696:
1692:
1678:
1675:
1674:
1672:
1669:
1668:
1662:
1656:
1653:
1649:
1646:
1645:
1644:
1641:
1639:
1636:
1635:
1633:
1630:
1629:
1623:
1617:
1614:
1612:
1609:
1605:
1602:
1600:
1597:
1595:
1592:
1591:
1590:
1587:
1583:
1580:
1578:
1575:
1574:
1573:
1570:
1566:
1563:
1561:
1558:
1556:
1553:
1552:
1551:
1548:
1547:
1545:
1542:
1541:
1535:
1529:
1526:
1524:
1521:
1519:
1516:
1514:
1511:
1509:
1506:
1504:
1501:
1499:
1496:
1494:
1491:
1489:
1486:
1484:
1481:
1479:
1476:
1474:
1471:
1469:
1466:
1465:
1463:
1460:
1459:
1453:
1447:
1444:
1440:
1437:
1435:
1432:
1430:
1427:
1425:
1422:
1420:
1417:
1416:
1415:
1412:
1410:
1407:
1405:
1402:
1400:
1397:
1393:
1390:
1389:
1388:
1385:
1384:
1382:
1379:
1378:
1372:
1364:
1361:
1360:
1359:
1356:
1352:
1349:
1347:
1344:
1343:
1342:
1339:
1338:
1336:
1333:
1332:
1326:
1323:
1321:
1317:
1311:
1308:
1306:
1303:
1301:
1298:
1296:
1293:
1292:
1290:
1288:
1284:
1278:
1275:
1273:
1270:
1268:
1265:
1264:
1262:
1260:
1259:Mitochondrial
1256:
1250:
1247:
1245:
1242:
1240:
1237:
1236:
1234:
1232:
1228:
1225:
1223:
1219:
1216:
1212:
1207:
1203:
1199:
1195:
1191:
1184:
1179:
1177:
1172:
1170:
1165:
1164:
1161:
1149:
1148:Jacques Monod
1146:
1144:
1141:
1140:
1138:
1134:
1126:
1123:
1121:
1118:
1117:
1116:
1113:
1111:
1110:Translational
1108:
1104:
1101:
1099:
1096:
1094:
1091:
1090:
1089:
1086:
1084:
1081:
1077:
1074:
1072:
1069:
1068:
1067:
1064:
1060:
1057:
1056:
1055:
1052:
1051:
1049:
1047:
1043:
1033:
1030:
1028:
1025:
1023:
1020:
1018:
1015:
1014:
1012:
1008:
1002:
999:
997:
994:
992:
989:
988:
986:
982:
979:
977:
973:
963:
960:
958:
955:
953:
950:
948:
945:
943:
940:
939:
937:
935:
931:
925:
922:
920:
917:
915:
912:
911:
909:
905:
899:
896:
894:
891:
889:
886:
885:
883:
879:
876:
874:
873:Transcription
870:
862:
859:
857:
854:
852:
849:
848:
847:
844:
840:
836:
832:
829:
828:
827:
826:Central dogma
824:
822:
819:
818:
816:
814:
808:
804:
797:
792:
790:
785:
783:
778:
777:
774:
768:
766:
764:
762:
761:
753:
749:
744:
739:
736:(5): 709–22.
735:
731:
727:
720:
717:
712:
708:
703:
698:
694:
690:
686:
682:
678:
674:
670:
663:
660:
655:
651:
646:
641:
637:
633:
629:
625:
621:
614:
611:
606:
602:
597:
592:
589:(1): 135–40.
588:
584:
580:
573:
570:
565:
561:
556:
551:
547:
543:
539:
535:
531:
524:
521:
516:
512:
507:
502:
497:
492:
488:
484:
480:
473:
471:
469:
467:
465:
463:
461:
459:
455:
450:
446:
442:
438:
434:
430:
427:(6): 568–76.
426:
422:
415:
412:
407:
403:
399:
395:
390:
385:
381:
377:
373:
366:
363:
356:
352:
349:
347:
344:
342:
339:
338:
334:
332:
330:
326:
322:
314:
312:
310:
306:
302:
297:
294:
293:
283:
279:
277:
273:
270:
267:
265:
262:
261:
257:
253:
249:
245:
243:
239:
235:
232:
229:
227:
224:
223:
219:
218:rocaglamide A
215:
214:hippuristanol
211:
207:
203:
199:
197:
193:
189:
186:
183:
181:
178:
177:
174:Key Features
173:
170:
167:
164:
163:
160:
158:
154:
150:
146:
142:
138:
134:
129:
127:
123:
118:
115:
111:
103:
101:
95:
93:
91:
87:
86:cap-dependent
83:
79:
71:
69:
67:
63:
59:
56:
53:
49:
45:
41:
37:
33:
29:
21:
1857:Class 2/RF3
1665:
1626:
1538:
1456:
1375:
1329:
1125:irreversible
1010:Key elements
907:Key elements
821:Genetic code
811:Introduction
733:
729:
719:
676:
672:
662:
627:
623:
613:
586:
582:
572:
537:
533:
523:
486:
482:
424:
420:
414:
379:
375:
365:
318:
298:
292:
289:
130:
126:RNA helicase
107:
99:
75:
55:RNA helicase
31:
27:
26:
2795:Start codon
2580:28S subunit
2359:39S subunit
2159:40S subunit
1896:60S subunit
1887:Cytoplasmic
1351:SUI1 family
1194:translation
976:Translation
813:to genetics
624:Translation
46:to promote
2846:Categories
2800:Stop codon
2144:RRP15-like
1954:RPL10-like
1703:Bacterial/
1320:Eukaryotic
1206:eukaryotic
1120:reversible
1083:lac operon
1059:imprinting
1054:Epigenetic
1046:Regulation
1001:Eukaryotic
947:5' capping
898:Eukaryotic
357:References
315:Regulation
128:activity.
112:binds the
1756:Archaeal/
1231:Bacterial
1198:bacterial
991:Bacterial
888:Bacterial
540:: 58–71.
534:Biochimie
398:0092-8674
96:Structure
1847:Class 1
1287:Archaeal
1214:Proteins
1202:archaeal
1103:microRNA
1017:Ribosome
996:Archaeal
952:Splicing
924:Promoter
893:Archaeal
837: →
833: →
752:16337595
711:27309803
654:27335721
564:25742741
515:26324716
441:22664984
406:14675538
335:See also
171:Isoforms
168:MW (kDa)
104:Subunits
72:Function
52:DEAD-box
2836:Biology
2149:RSL24D1
1826:a/eEF-2
1765:a/eEF-1
856:RNA→DNA
851:RNA→RNA
839:Protein
702:4946961
681:Bibcode
645:4909409
605:9702200
555:4458453
506:4591800
449:9201095
165:Subunit
80:to the
2822:Portal
2317:RPS27A
2257:RPS15A
2196:RPS4Y2
2192:RPS4Y1
2186:RPS4 (
2104:RPL37A
2094:RPL36A
2084:RPL35A
2044:RPL27A
2024:RPL23A
1999:RPL18A
1974:RPL13A
1949:RPL10A
1404:γ
1399:β
1392:kinase
1387:α
750:
709:
699:
673:Nature
652:
642:
603:
562:
552:
513:
503:
447:
439:
404:
396:
351:5' cap
309:eIF4G2
276:eIF4G3
272:eIF4G1
242:eIF4E3
238:eIF4E2
234:eIF4E1
208:, and
196:eIF4A3
192:eIF4A2
188:eIF4A1
139:, and
117:5' cap
82:5' cap
40:5' cap
2587:MRPS1
2366:MRPL1
2337:RACK1
2332:RPS30
2327:RPS29
2322:RPS28
2312:RPS27
2307:RPS26
2302:RPS25
2297:RPS24
2292:RPS23
2287:RPS21
2282:RPS20
2277:RPS19
2272:RPS18
2267:RPS17
2262:RPS16
2252:RPS15
2247:RPS14
2242:RPS13
2237:RPS12
2232:RPS11
2227:RPS10
2188:RPS4X
2182:RPS3A
2139:RPLP2
2134:RPLP1
2129:RPLP0
2124:RPL41
2119:RPL40
2114:RPL39
2109:RPL38
2099:RPL37
2089:RPL36
2079:RPL35
2074:RPL34
2069:RPL32
2064:RPL31
2059:RPL30
2054:RPL29
2049:RPL28
2039:RPL27
2034:RPL26
2029:RPL24
2019:RPL23
2014:RPL22
2009:RPL21
2004:RPL19
1994:RPL18
1989:RPL17
1984:RPL15
1979:RPL14
1969:RPL13
1964:RPL12
1959:RPL11
1944:RPL10
1929:RPL7A
1866:GSPT2
1861:GSPT1
1717:EF-Ts
1712:EF-Tu
1643:EIF5A
1446:eIF2D
1414:eIF2B
1409:eIF2A
1358:eIF1A
1277:MTIF3
1272:MTIF2
1267:MTIF1
984:Types
881:Types
445:S2CID
321:eIF4E
305:eIF4H
301:eIF4B
264:eIF4G
256:4EBP3
252:4EBP2
248:4EBP1
226:eIF4E
210:PDCD4
206:eIF4H
202:eIF4B
180:eIF4A
153:eIF4G
149:eIF4G
141:eIF4G
137:eIF4E
133:eIF4A
110:eIF4E
66:eIF4G
62:eIF4E
58:eIF4A
32:eIF4F
2222:RPS9
2217:RPS8
2212:RPS7
2207:RPS6
2202:RPS5
2177:RPS3
2172:RPS2
2167:RPSA
1939:RPL9
1934:RPL8
1924:RPL7
1919:RPL6
1914:RPL5
1909:RPL4
1904:RPL3
1851:eRF1
1747:GFM2
1742:GFM1
1737:TSFM
1732:EF-P
1727:EF-4
1722:EF-G
1677:EIF6
1667:eIF6
1638:EIF5
1628:eIF5
1540:eIF4
1458:eIF3
1377:eIF2
1341:eIF1
1331:eIF1
1310:aIF6
1305:aIF5
1300:aIF2
1295:aIF1
748:PMID
707:PMID
650:PMID
601:PMID
560:PMID
511:PMID
437:PMID
402:PMID
394:ISSN
376:Cell
325:mTOR
319:The
303:and
282:PABP
254:and
157:PABP
155:and
147:via
145:eIF3
1249:IF3
1244:IF2
1239:IF1
835:RNA
831:DNA
738:doi
697:PMC
689:doi
677:534
640:PMC
632:doi
591:doi
550:PMC
542:doi
538:114
501:PMC
491:doi
487:290
429:doi
384:doi
380:115
268:175
42:of
2848::
2757:35
2752:34
2747:33
2742:32
2737:31
2732:30
2727:29
2722:28
2717:27
2712:26
2707:25
2702:24
2697:23
2692:22
2687:21
2682:20
2677:19
2672:18
2667:17
2662:16
2657:15
2652:14
2647:13
2642:12
2637:11
2632:10
2571:42
2566:41
2561:40
2556:39
2551:38
2546:37
2541:36
2536:35
2531:34
2526:33
2521:32
2516:31
2511:30
2506:29
2501:28
2496:27
2491:26
2486:25
2481:24
2476:23
2471:22
2466:21
2461:20
2456:19
2451:18
2446:17
2441:16
2436:15
2431:14
2426:13
2421:12
2416:11
2411:10
2194:,
2190:,
1802:P3
1797:P2
1792:P1
1770:A1
1655:5B
1572:E1
1204:,
1200:,
1192::
746:.
734:20
732:.
728:.
705:.
695:.
687:.
675:.
671:.
648:.
638:.
626:.
622:.
599:.
585:.
581:.
558:.
548:.
536:.
532:.
509:.
499:.
485:.
481:.
457:^
443:.
435:.
425:19
423:.
400:.
392:.
378:.
374:.
284:.
274:,
258:.
250:,
240:,
236:,
230:25
216:,
204:,
194:,
190:,
184:46
135:,
114:mG
2824::
2807:/
2627:9
2622:8
2617:7
2612:6
2607:5
2602:4
2597:3
2592:2
2406:9
2401:8
2396:7
2391:6
2386:5
2381:4
2376:3
2371:2
2198:)
1819:G
1814:E
1809:D
1787:B
1780:3
1775:2
1648:2
1616:H
1611:B
1604:3
1599:2
1594:1
1589:G
1582:3
1577:2
1565:3
1560:2
1555:1
1550:A
1528:M
1523:L
1518:K
1513:J
1508:I
1503:H
1498:G
1493:F
1488:E
1483:D
1478:C
1473:B
1468:A
1439:5
1434:4
1429:3
1424:2
1419:1
1363:Y
1346:B
1208:)
1196:(
1182:e
1175:t
1168:v
795:e
788:t
781:v
754:.
740::
713:.
691::
683::
656:.
634::
628:4
607:.
593::
587:2
566:.
544::
517:.
493::
451:.
431::
408:.
386::
30:(
Text is available under the Creative Commons Attribution-ShareAlike License. Additional terms may apply.
