1165:, juvenile cataracts, and a predisposition to cancers such as osteosarcomas. Chromosomal rearrangements causing genomic instability are found in the cells of Rothmund-Thomson syndrome patients. RecQ is a family of DNA helicase enzymes that are found in various organisms including bacteria, archaea, and eukaryotes (like humans). These enzymes play important roles in DNA metabolism during DNA replication, recombination, and repair. There are five known RecQ helicase proteins in humans: RecQ1, BLM, WRN, RecQ4, and RecQ5. Mutations in some of these genes are associated with genetic disorders. For instance, mutations in the BLM gene cause Bloom syndrome, which is characterized by increased cancer risk and other health issues. Mutations in the WRN gene lead to Werner syndrome, a condition characterized by premature aging and an increased risk of age-related diseases. RecQ helicases are crucial for maintaining genomic stability and integrity. They help prevent the accumulation of genetic abnormalities that can lead to diseases like cancer. Genome integrity depends on the RecQ DNA helicase family, which includes DNA repair, recombination, replication, and transcription processes. Genome instability and early aging are conditions that arise from mutations in human RecQ helicases. RecQ helicase Sgs1 is missing in yeast cells, making them useful models for comprehending human cell abnormalities and the RecQ helicase function. The RecQ helicase family member, RECQ1, is connected to a small number of uncommon genetic cancer disorders in individuals. It participates in transcription, the cell cycle, and DNA repair. According to recent research, missense mutations in the RECQ1 gene may play a role in the development of familial breast cancer. DNA helicases are frequently attracted to regions of DNA damage and are essential for cellular DNA replication, recombination, repair, and transcription. Chemical manipulation of their molecular processes can change the rate at which cancer cells divide, as well as, the efficiency of transactions and cellular homeostasis. Small-molecule-induced entrapment of DNA helicases, a type of DNA metabolic protein, may have deleterious consequences on rapidly proliferating cancer cells, which could be effective in cancer treatment.
1346:, Inc. This assay is a time-resolved fluorescence quenching assay that utilizes the PerkinElmer "SignalClimb" technology that is based on two labels that bind in close proximity to one another but on opposite DNA strands. One label is a fluorescent lanthanide chelate, which serves as the label that is monitored through an adequate 96/384 well plate reader. The other label is an organic quencher molecule. The basis of this assay is the "quenching" or repressing of the lanthanide chelate signal by the organic quencher molecule when the two are in close proximity – as they would be when the DNA duplex is in its native state. Upon helicase activity on the duplex, the quencher and lanthanide labels get separated as the DNA is unwound. This loss in proximity negates the quenchers ability to repress the lanthanide signal, causing a detectable increase in fluorescence that is representative of the amount of unwound DNA and can be used as a quantifiable measurement of helicase activity. The execution and use of single-molecule fluorescence imaging techniques, focusing on methods that include optical trapping in conjunction with epifluorescent imaging, and also surface immobilization in conjunction with total internal reflection fluorescence visualization. Combined with microchannel flow cells and microfluidic control, allow individual fluorescently labeled protein and DNA molecules to be imaged and tracked, affording measurement of DNA unwinding and translocation at single-molecule resolution.
123:
repair processes. Its primary function is to unwind the double-stranded DNA molecule by breaking the hydrogen bonds between the complementary base pairs, allowing the DNA strands to separate. This creates a replication fork, which serves as a template for synthesizing new DNA strands. Helicase is an essential component of cellular mechanisms that ensures accurate DNA replication and maintenance of genetic information. DNA helicase catalyzes regression. RecG and the enzyme PriA work together to rewind duplex DNA, creating a
Holliday junction. RecG releases bound proteins and the PriA helicase facilitates DNA reloading to resume DNA replication. RecG replaces the single-strand binding protein (SSB), which regulates the helicase-fork loading sites during fork regression. The SSB protein interacts with DNA helicases PriA and RecG to recover stalled DNA replication forks. These enzymes must bind to the SSB-helicase to be loaded onto stalled forks. Thermal sliding and DNA duplex binding are possibly supported by the wedge domain of RecG's association with the SSB linker. In a regression reaction facilitated by RecG and ATPHollidayjunctions are created for later processing.
1289:
local strand separation occurs by a process wherein the helicase enzyme is loaded at any place along the duplex. This is usually aided by a single-strand region of the RNA, and the loading of the enzyme is accompanied with ATP binding. Once the helicase and ATP are bound, local strand separation occurs, which requires binding of ATP but not the actual process of ATP hydrolysis. Presented with fewer base pairs the duplex then dissociates without further assistance from the enzyme. This mode of unwinding is used by the
228:
1325:. Following detection of the single-strand DNA, the amount of radioactive tag that is on the single-strand DNA is quantified to give a numerical value for the amount of double-strand DNA unwinding.The strand displacement assay is acceptable for qualitative analysis, its inability to display results for more than a single time point, its time consumption, and its dependence on radioactive compounds for labeling warranted the need for development of diagnostics that can monitor helicase activity in real time.
1355:
DNA leading strand, or the DNA lagging strand. To characterize this helicase feature, a partially duplex DNA is used as the substrate that has a central single-strand DNA region with different lengths of duplex regions of DNA (one short region that runs 5'→3' and one longer region that runs 3'→5') on both sides of this region. Once the helicase is added to that central single-strand region, the polarity is determined by characterization on the newly formed single-strand DNA.
1244:
1236:
209:. Studies have shown that helicases may act passively, waiting for uncatalyzed unwinding to take place and then translocating between displaced strands, or can play an active role in catalyzing strand separation using the energy generated in ATP hydrolysis. In the latter case, the helicase acts comparably to an active motor, unwinding and translocating along its substrate as a direct result of its ATPase activity. Helicases may process much faster
988:: This is the largest group of helicases that are involved in varied cellular processes. They are characterized by the presence of nine conserved motifs: Q, I, Ia, Ib, and II through VI. This group is mainly composed of DEAD-box RNA helicases. Some other helicases included in SF2 are the RecQ-like family and the Snf2-like enzymes. Most of the SF2 helicases are type A with a few exceptions such as the XPD family. They have a RecA-like-fold core.
5953:
8124:
1313:. These methods range from assays that are qualitative (assays that usually entail results that do not involve values or measurements) to quantitative (assays with numerical results that can be utilized in statistical and numerical analysis). In 1982–1983, the first direct biochemical assay was developed for measuring helicase activity. This method was called a "strand displacement assay".
1130:(3'-5') belong to the Superfamily II group of helicases, which help to maintain stability of the genome and suppress inappropriate recombination. Deficiencies and/or mutations in RecQ family helicases display aberrant genetic recombination and/or DNA replication, which leads to chromosomal instability and an overall decreased ability to proliferate. Mutations in RecQ family helicases BLM,
1120:
1064:
genital abnormalities, seizures, limited language use and ability, and alpha-thalassemia. The phenotype seen in ATR-X suggests that the mutation of ATRX gene causes the downregulation of gene expression, such as the alpha-globin genes. It is still unknown what causes the expression of the various characteristics of ATR-X in different patients.
805:
other bacteria, viruses, yeast, flies, and higher eukaryotes. To date, at least 14 different helicases have been isolated from single celled organisms, 6 helicases from bacteriophages, 12 from viruses, 15 from yeast, 8 from plants, 11 from calf thymus, and approximately 25 helicases from human cells. Below is a history of helicase discovery:
31:
1285:
viruses. However, not all RNA helicases exhibit helicase activity as defined by enzymatic function, i.e., proteins of the Swi/Snf family. Although these proteins carry the typical helicase motifs, hydrolize ATP in a nucleic acid-dependent manner, and are built around a helicase core, in general, no unwinding activity is observed.
1223:, FANCM helicase promotes NCO and antagonizes the formation of CO recombinants. Another helicase, RECQ4A/B, also independently reduces COs. It was suggested that COs are restricted because of the long term costs of CO recombination, that is, the breaking up of favourable genetic combinations of alleles built up by past
1284:
RNA helicases and DNA helicases can be found together in all the helicase superfamilies except for SF6. All the eukaryotic RNA helicases that have been identified up to date are non-ring forming and are part of SF1 and SF2. On the other hand, ring-forming RNA helicases have been found in bacteria and
1110:
In xeroderma pigmentosa, the XPD helicase mutation exists at the site of ATP or DNA binding. This results in a structurally functional helicase able to facilitate transcription, however it inhibits its function in unwinding DNA and DNA repair. The lack of a cell's ability to repair mutations, such as
1063:
Various types of mutations found in ATRX have been found to be associated with ATR-X, including most commonly single-base missense mutations, as well as nonsense, frameshift, and deletion mutations. Characteristics of ATR-X include: microcephaly, skeletal and facial abnormalities, mental retardation,
1354:
Helicase polarity, which is also deemed "directionality", is defined as the direction (characterized as 5'→3' or 3'→5') of helicase movement on the DNA/RNA single-strand along which it is moving. This determination of polarity is vital in f.ex. determining whether the tested helicase attaches to the
1288:
RNA helicases that do exhibit unwinding activity have been characterized by at least two different mechanisms: canonical duplex unwinding and local strand separation. Canonical duplex unwinding is the stepwise directional separation of a duplex strand, as described above, for DNA unwinding. However,
1149:
Bloom syndrome is characterized by a predisposition to cancer with early onset, with a mean age-of-onset of 24 years. Cells of Bloom syndrome patients show a high frequency of reciprocal exchange between sister chromatids (SCEs) and excessive chromosomal damage. There is evidence to suggest that BLM
1107:
helicase to cut DNA segments meant for transcription. Although current evidence points to a defect in the XPD helicase resulting in a loss of flexibility in the protein in cases of
Cockayne syndrome, it is still unclear how this protein structure leads to the symptoms described in Cockayne syndrome.
950:
Helicases are classified in 6 groups (superfamilies) based on their shared sequence motifs. Helicases not forming a ring structure are in superfamilies 1 and 2, and ring-forming helicases form part of superfamilies 3 to 6. Helicases are also classified as α or β depending on if they work with single
804:
in 1976. This helicase was described as a "DNA unwinding enzyme" that is "found to denature DNA duplexes in an ATP-dependent reaction, without detectably degrading". The first eukaryotic DNA helicase discovered was in 1978 in the lily plant. Since then, DNA helicases were discovered and isolated in
1247:
This image represents the different promoter sequences and accessory domains that aid in RNA unwinding (local strand separation). The regions in red are ATP binding domains and the regions in yellow are RNA interaction domains. Specific sequences termed DEAD box proteins are also present that help
560:
is temperature of the system). Due to this significant activation barrier, its unwinding progression is affected largely by the sequence of nucleic acids within the molecule to unwind, and the presence of destabilization forces acting on the replication fork. Certain nucleic acid combinations will
122:
involve the separation of nucleic acid strands that necessitates the use of helicases. Some specialized helicases are also involved in sensing of viral nucleic acids during infection and fulfill an immunological function. A helicase is an enzyme that plays a crucial role in the DNA replication and
1153:
Werner syndrome is a disorder of premature aging, with symptoms including early onset of atherosclerosis and osteoporosis and other age related diseases, a high occurrence of sarcoma, and death often occurring from myocardial infarction or cancer in the 4th to 6th decade of life. Cells of Werner
1102:
XPD helicase mutations leading to trichothiodystrophy are found throughout the protein in various locations involved in protein-protein interactions. This mutation results in an unstable protein due to its inability to form stabilizing interactions with other proteins at the points of mutations.
1098:
by unwinding DNA. TFIIH assists in repairing damaged DNA such as sun damage. A mutation in the XPD helicase that helps form this complex and contributes to its function causes the sensitivity to sunlight seen in all three diseases, as well as the increased risk of cancer seen in XP and premature
1047:
gene encodes the ATP-dependent helicase, ATRX (also known as XH2 and XNP) of the SNF2 subgroup family, that is thought to be responsible for functions such as chromatin remodeling, gene regulation, and DNA methylation. These functions assist in prevention of apoptosis, resulting in cortical size
791:
These two categories of helicases may also be modeled as mechanisms. In such models, the passive helicases are conceptualized as
Brownian ratchets, driven by thermal fluctuations and subsequent anisotropic gradients across the DNA lattice. The active helicases, in contrast, are conceptualized as
1106:
It has been suggested that XPD helicase mutations leading to
Cockayne syndrome could be the result of mutations within XPD, causing rigidity of the protein and subsequent inability to switch from repair functions to transcription functions due to a "locking" in repair mode. This could cause the
1338:
assay, an assay based on flashplate technology, homogenous time-resolved fluorescence quenching assays, and electrochemiluminescence-based helicase assays". With the use of specialized mathematical equations, some of these assays can be utilized to determine how many base paired nucleotides a
1260:
initiation. They also play an important role in sensing viral RNAs. RNA helicases are involved in the mediation of antiviral immune response because they can identify foreign RNAs in vertebrates. About 80% of all viruses are RNA viruses and they contain their own RNA helicases. Defective RNA
1329:
Other methods were later developed that incorporated some, if not all of the following: high-throughput mechanics, the use of non-radioactive nucleotide labeling, faster reaction time/less time consumption, real-time monitoring of helicase activity (using kinetic measurement instead of
792:
stepping motors – also known as powerstroke motors – utilizing either a conformational "inch worm" or a hand-over-hand "walking" mechanism to progress. Depending upon the organism, such helix-traversing progress can occur at rotational speeds in the range of 5,000 to 10,000 R.P.M.
994:: Superfamily 3 consists of AAA+ helicases encoded mainly by small DNA viruses and some large nucleocytoplasmic DNA viruses. They have a 3’-5’ translocation directionality, meaning that they are all type A helicases. The most known SF3 helicase is the papilloma virus E1 helicase.
1083:(TTD). Cockayne syndrome and trichothiodystrophy are both developmental disorders involving sensitivity to UV light and premature aging, and Cockayne syndrome exhibits severe mental retardation from the time of birth. The XPD helicase mutation has also been implicated in
1075:(Xeroderma pigmentosum factor D, also known as protein ERCC2) is a 5'-3', Superfamily II, ATP-dependent helicase containing iron-sulphur cluster domains. Inherited point mutations in XPD helicase have been shown to be associated with accelerated aging disorders such as
1048:
regulation, as well as a contribution to the survival of hippocampal and cortical structures, affecting memory and learning. This helicase is located on the X chromosome (Xq13.1-q21.1), in the pericentromeric heterochromatin and binds to
463:
Factors that contribute to the height of the activation barrier include: specific nucleic acid sequence of the molecule involved, the number of base pairs involved, tension present on the replication fork, and destabilization forces.
970:: This superfamily can be further subdivided into SF1A and SF1B helicases. In this group helicases can have either 3’-5’ (SF1A subfamily) or 5’-3’(SF1B subfamily) translocation polarity. The most known SF1A helicases are Rep and
6759:
341:
677:, where the system lacks a significant barrier, as the helicase can destabilize the nucleic acids, unwinding the double-helix at a constant rate, regardless of the nucleic acid sequence. In active helicases,
3867:
Debnath S., Sharma S. RECQ1 Helicase in
Genomic Stability and Cancer. Genes. 2020:11. doi: 10.3390/genes11060622], Debnath S., Sharma S. RECQ1 Helicase in Genomic Stability and Cancer. Genes. 2020:11. doi:
472:
The size of the activation barrier to overcome by the helicase contributes to its classification as an active or passive helicase. In passive helicases, a significant activation barrier exists (defined as
1296:
An RNA helicase database is currently available online that contains a comprehensive list of RNA helicases with information such as sequence, structure, and biochemical and cellular functions.
734:
Active helicases show similar behaviour when acting on both double-strand nucleic acids, dsNA, or ssNA, in regards to the rates of unwinding and rates of translocation, where in both systems
6769:
638:) (translocation along the single-strand nucleic acid, ssNA), due to its reliance on the transient unraveling of the base pairs at the replication fork to determine its rate of unwinding.
227:
1154:
syndrome patients exhibit a reduced reproductive lifespan with chromosomal breaks and translocations, as well as large deletions of chromosomal components, causing genomic instability.
6764:
399:
3430:
Schaeffer L, Roy R, Humbert S, Moncollin V, Vermeulen W, Hoeijmakers JH, et al. (April 1993). "DNA repair helicase: a component of BTF2 (TFIIH) basic transcription factor".
675:
507:
3135:
Stevenson RE (1993). Adam MP, Everman DB, Mirzaa GM, Pagon RA, Wallace SE, Bean LJ, Gripp KW, Amemiya A (eds.). "Alpha-Thalassemia X-Linked
Intellectual Disability Syndrome".
786:
729:
91:. There are many helicases, representing the great variety of processes in which strand separation must be catalyzed. Approximately 1% of eukaryotic genes code for helicases.
6951:
428:
759:
702:
6884:
6862:
534:
457:
938:
The presence of these helicase motifs allows putative helicase activity to be attributed to a given protein, but does not necessarily confirm it as an active helicase.
636:
3905:
6680:
1261:
helicases have been linked to cancers, infectious diseases and neuro-degenerative disorders. Some neurological disorders associated with defective RNA helicases are:
1056:
protein, with over 90% of them being located in the zinc finger and helicase domains. Mutations of ATRX can result in X-linked-alpha-thalassaemia-mental retardation (
2460:
Linder, P., Lasko, P.F., Ashburner, M., Leroy, P., Nielson, P.J., Nishi, K., Schneir, J., Slonimski, P.P. (1989) Birth of the DEAD-box. Nature (London) 337, 121-122.
597:
3909:
3765:
Kitao S, Shimamoto A, Goto M, Miller RW, Smithson WA, Lindor NM, Furuichi Y (May 1999). "Mutations in RECQL4 cause a subset of cases of
Rothmund-Thomson syndrome".
3583:
Ouyang KJ, Woo LL, Ellis NA (2008). "Homologous recombination and maintenance of genome integrity: cancer and aging through the prism of human RecQ helicases".
558:
367:
267:
2052:
6790:
942:
do, however, support an evolutionary homology among enzymes. Based on these helicase motifs, a number of helicase superfamilies have been distinguished.
963:. They are also classified by translocation polarity. If translocation occurs 3’-5’ the helicase is type A; if translocation occurs 5’-3’ it is type B.
6685:
4767:
4639:
Pavankumar TL, Exell JC, Kowalczykowski SC (1 January 2016). "Direct
Fluorescent Imaging of Translocation and Unwinding by Individual DNA Helicases".
1052:. Studies have shown that ATRX plays a role in rDNA methylation and is essential for embryonic development. Mutations have been found throughout the
7644:
6852:
1321:
of DNA duplexes. Following helicase treatment, the single-strand DNA is visually detected as separate from the double-strand DNA by non-denaturing
6944:
5886:
7174:
3722:
Gray MD, Shen JC, Kamath-Loeb AS, Blank A, Sopher BL, Martin GM, et al. (September 1997). "The Werner syndrome protein is a DNA helicase".
3376:
Sung P, Bailly V, Weber C, Thompson LH, Prakash L, Prakash S (October 1993). "Human xeroderma pigmentosum group D gene encodes a DNA helicase".
5860:
5331:
5294:
1335:
1278:
4238:
Jankowsky E, Fairman-Williams ME (2010). "An introduction to RNA helicases: superfamilies, families, and major themes". In
Jankowsky E (ed.).
2619:
Tuteja R, Malhotra P, Song P, Tuteja N, Chauhan VS (2002). "Isolation and characterization of an eIF-4A homologue from
Plasmodium cynomolgi".
6491:
4699:
4247:
1016:: They contain the core AAA+ that is not included in the SF3 classification. Some proteins in the SF6 group are: mini chromosome maintenance
1000:: All SF4 family helicases have a type B polarity (5’-3’). They have a RecA fold. The most studied SF4 helicase is gp4 from bacteriophage T7.
7143:
5521:
1330:
endpoint/single point analysis). These methodologies include: "a rapid quench flow method, fluorescence-based assays, filtration assays, a
1211:
1087:(XP), a disorder characterized by sensitivity to UV light and resulting in a several 1000-fold increase in the development of skin cancer.
275:
4029:"Rad51/Dmc1 paralogs and mediators oppose DNA helicases to limit hybrid DNA formation and promote crossovers during meiotic recombination"
5576:
3672:"The Bloom's syndrome helicase (BLM) interacts physically and functionally with p12, the smallest subunit of human DNA polymerase delta"
6937:
6625:
5829:
5760:
5414:
2414:"Two related superfamilies of putative helicases involved in replication, recombination, repair and expression of DNA and RNA genomes"
1879:"Erratum: Opening of nucleic-acid double strands by helicases: Active versus passive opening [Phys. Rev. E 71, 011904 (2005)]"
175:
64:
7843:
6195:
5989:
5423:
4989:
4656:
3305:
2980:"Mutations in a putative global transcriptional regulator cause X-linked mental retardation with alpha-thalassemia (ATR-X syndrome)"
1134:, and WRN, which play a role in regulating homologous recombination, have been shown to result in the autosomal recessive diseases
1103:
This, in turn, destabilizes the entire TFIIH complex, which leads to defects with transcription and repair mechanisms of the cell.
840:– SV40 large tumor antigen reported as a viral helicase (1st reported viral protein that was determined to serve as a DNA helicase)
40:
helicase RuvA (note that the heilcase core in RuvAB complex is RuvB and not RuvA and that RuvA alone do not show helicase activity)
6336:
5844:
5476:
3040:"ATRX encodes a novel member of the SNF2 family of proteins: mutations point to a common mechanism underlying the ATR-X syndrome"
1173:
3334:"Reconstitution of the transcription factor TFIIH: assignment of functions for the three enzymatic subunits, XPB, XPD, and cdk7"
3160:"The helicase XPD unwinds bubble structures and is not stalled by DNA lesions removed by the nucleotide excision repair pathway"
7734:
7729:
5336:
7999:
1139:
7751:
6909:
6904:
6464:
6282:
5146:
4996:
4760:
1331:
1262:
1248:
catalyze reactions in which ATP does not need to be directly hydrolyzed, as long as it binds to the domains on the strand.
8114:
7799:
7116:
6774:
6662:
6630:
6615:
5819:
5726:
2886:
Iyer LM, Leipe DD, Koonin EV, Aravind L (2004). "Evolutionary history and higher order classification of AAA+ ATPases".
249:
Enzymatic helicase action, such as unwinding nucleic acids is achieved through the lowering of the activation barrier (
7721:
6297:
5137:
4805:
4780:
4582:"RecQ helicase translocates along single-stranded DNA with a moderate processivity and tight mechanochemical coupling"
2580:"Purification and characterization of a DNA helicase from pea chloroplast that translocates in the 3'-to-5' direction"
4081:"Multiple mechanisms limit meiotic crossovers: TOP3α and two BLM homologs antagonize crossovers in parallel to FANCM"
2687:
Singleton MR, Dillingham MS, Wigley DB (2007). "Structure and mechanism of helicases and nucleic acid translocases".
2060:
5748:
5572:
5565:
5266:
5242:
5111:
4943:
4890:
4872:
4784:
3288:
Lainé JP, Mocquet V, Egly JM (2006). "TFIIH enzymatic activities in transcription and nucleotide excision repair".
1095:
1017:
7984:
569:), while various destabilizing forces can increase the unwinding rate. In passive systems, the rate of unwinding (
8100:
8087:
8074:
8061:
8048:
8035:
8022:
7780:
7321:
7219:
7044:
7040:
7017:
6990:
6977:
6964:
6895:
6873:
6848:
6823:
6743:
6351:
6311:
6256:
6233:
6205:
6173:
6039:
5320:
1194:
1049:
982:
bacteria. The most known Helicases in the SF1B group are RecD and Dda helicases. They have a RecA-like-fold core.
76:
7994:
6126:
1342:
Commercially available diagnostic kits are also available. One such kit is the "Trupoint" diagnostic assay from
8149:
7948:
7891:
7335:
7030:
6995:
6968:
6360:
6341:
6272:
6006:
5743:
5665:
5514:
5481:
4753:
4739:
4729:
2081:
1181:
1158:
928:
103:
98:
codes for 95 non-redundant helicases: 64 RNA helicases and 31 DNA helicases. Many cellular processes, such as
7896:
7705:
7668:
7007:
6218:
4883:
4814:
1266:
7435:
7075:
6672:
6445:
6355:
5855:
5765:
5560:
5380:
5311:
3238:"XPD helicase structures and activities: insights into the cancer and aging phenotypes from XPD mutations"
1413:
1290:
1270:
917:
374:
143:
85:
7917:
7836:
7565:
7473:
6526:
6481:
6183:
6168:
6104:
6084:
5982:
5621:
5306:
5075:
4745:
3873:
1555:
1257:
1189:
1084:
731:, due to the active helicase ability to directly destabilize the replication fork to promote unwinding.
644:
476:
269:) of each specific action. The activation barrier is a result of various factors, and can be defined by
155:
111:
107:
7989:
5967:
4079:
Séguéla-Arnaud M, Crismani W, Larchevêque C, Mazel J, Froger N, Choinard S, et al. (April 2015).
764:
707:
6440:
6435:
6315:
6178:
6158:
6067:
5546:
5353:
5326:
5277:
4593:
4510:
4415:
4092:
3983:
3439:
3385:
2791:
2532:
2226:"Prokaryotic and eukaryotic DNA helicases. Essential molecular motor proteins for cellular machinery"
2182:"Bacteriophage T4 gene 41 protein, required for the synthesis of RNA primers, is also a DNA helicase"
1890:
1736:
1219:
888:– Isolation and characterization of the first biochemically active malarial parasite DNA helicase –
406:
7953:
7770:
6703:
6695:
6476:
6143:
6079:
6043:
5956:
5643:
5507:
5083:
2373:"A new DNA-dependent ATPase which stimulates yeast DNA polymerase I and has DNA-unwinding activity"
1111:
those caused by sun damage, is the cause of the high cancer rate in xeroderma pigmentosa patients.
1080:
971:
737:
680:
159:
119:
71:
512:
435:
8154:
7886:
7785:
7351:
6929:
6566:
6504:
6455:
6190:
6017:
3790:
3747:
3670:
Selak N, Bachrati CZ, Shevelev I, Dietschy T, van Loon B, Jacob A, et al. (September 2008).
3608:
3515:
3409:
2955:
939:
537:
1094:
complex, a transcription and repair factor in the cell. As part of this complex, it facilitates
221:
due to the presence of accessory proteins that aid in the destabilization of the fork junction.
1206:
Rqh1 also directs NCO meiotic recombination. These helicases, through their ability to unwind
602:
170:, and RNA degradation are all facilitated by helicases. Helicases move incrementally along one
8144:
7025:
6581:
6571:
6561:
6486:
6470:
6429:
6415:
6410:
6148:
6111:
5839:
5289:
5106:
4705:
4695:
4672:
4652:
4621:
4562:
4492:
4443:
4384:
4343:
4294:
4243:
4220:
4176:
4120:
4058:
4009:
3952:
3944:
3849:
3831:
3782:
3739:
3701:
3649:
3600:
3565:
3507:
3455:
3401:
3355:
3311:
3301:
3267:
3189:
3140:
3117:
3061:
3001:
2947:
2903:
2868:
2819:
2760:
2704:
2636:
2601:
2560:
2501:
2443:
2394:
2353:
2304:
2255:
2203:
2157:
2119:
2022:
1958:
1826:
1764:
1705:
1661:
1607:
1274:
1235:
1224:
1185:
1076:
913:
905:
2700:
901:
The common function of helicases accounts for the fact that they display a certain degree of
7932:
7927:
7901:
7829:
7415:
7361:
7343:
7209:
7199:
7153:
6914:
6576:
6556:
6498:
6394:
6292:
6277:
6223:
6121:
6116:
5975:
5246:
5095:
5090:
4982:
4662:
4644:
4611:
4601:
4552:
4482:
4474:
4433:
4423:
4374:
4333:
4325:
4284:
4276:
4210:
4166:
4158:
4110:
4100:
4048:
4040:
3999:
3991:
3936:
3839:
3821:
3774:
3731:
3691:
3683:
3639:
3592:
3555:
3497:
3489:
3447:
3393:
3345:
3293:
3257:
3249:
3179:
3171:
3107:
3097:
3051:
2991:
2939:
2895:
2858:
2850:
2809:
2799:
2750:
2742:
2696:
2628:
2591:
2550:
2540:
2491:
2483:
2433:
2425:
2384:
2343:
2335:
2294:
2286:
2245:
2237:
2193:
2149:
2109:
2012:
2004:
1948:
1940:
1898:
1816:
1808:
1754:
1744:
1695:
1651:
1643:
1597:
1587:
1486:
1482:
1243:
572:
36:
7228:
1530:
1457:
1453:
1437:
7979:
7963:
7876:
7762:
7651:
7465:
7165:
6985:
6837:
6827:
6649:
6620:
6246:
6153:
6138:
5555:
5459:
5251:
5125:
4843:
4793:
4776:
3898:
3886:
3626:
Ellis NA, Groden J, Ye TZ, Straughen J, Lennon DJ, Ciocci S, et al. (November 1995).
1502:
1498:
1490:
1392:
1143:
234:
186:
99:
4735:
4725:
1797:"Single-molecule studies reveal dynamics of DNA unwinding by the ring-shaped T7 helicase"
4597:
4419:
4404:"ATP hydrolysis is required for DEAD-box protein recycling but not for duplex unwinding"
4096:
3987:
3502:
3477:
3443:
3389:
2795:
2536:
2098:"Enzymic unwinding of DNA. 2. Chain separation by an ATP-dependent DNA unwinding enzyme"
1894:
1740:
1725:"Real-time observation of bacteriophage T4 gp41 helicase reveals an unwinding mechanism"
154:. They also function to remove nucleic acid-associated proteins and catalyze homologous
8128:
8017:
7958:
7085:
6805:
6644:
6551:
6543:
6420:
6383:
5099:
5079:
4667:
4616:
4581:
4487:
4462:
4438:
4403:
4338:
4313:
4289:
4264:
4171:
4146:
4115:
4080:
4053:
4028:
4004:
3971:
3844:
3809:
3696:
3671:
3262:
3237:
3184:
3159:
3112:
3085:
2854:
2814:
2780:"Structural and mechanistic insight into DNA unwinding by Deinococcus radiodurans UvrD"
2779:
2755:
2730:
2348:
2339:
2323:
2250:
2225:
2114:
2097:
2017:
1988:
1953:
1928:
1821:
1796:
1759:
1724:
1656:
1631:
1602:
1575:
1135:
1057:
909:
543:
352:
252:
4557:
4540:
3350:
3333:
3297:
2863:
2838:
2632:
2496:
2471:
2438:
2413:
2389:
2372:
2299:
2274:
2198:
2181:
1878:
8138:
7922:
7881:
7629:
7239:
6074:
5867:
5688:
5301:
5228:
4838:
3972:"The fission yeast FANCM ortholog directs non-crossover recombination during meiosis"
3940:
3794:
3644:
3627:
2996:
2979:
2596:
2579:
2555:
2520:
2241:
1318:
1203:
1127:
1025:
979:
975:
882:– Report of the discovery of the first purified chloroplast DNA helicase from the pea
206:
190:
147:
60:
3751:
3519:
3038:
Picketts DJ, Higgs DR, Bachoo S, Blake DJ, Quarrell OW, Gibbons RJ (December 1996).
7871:
7614:
7587:
7516:
7509:
7492:
7487:
7461:
6163:
6133:
6062:
5834:
5803:
5753:
5736:
5683:
5636:
5440:
3612:
3413:
2140:
Hotta Y, Stern H (May 1978). "DNA unwinding protein from meiotic cells of Lilium".
1364:
1202:-family DNA helicase FmI1 directs NCO recombination formation during meiosis. The
1162:
925:
179:
171:
163:
135:
95:
68:
3236:
Fan L, Fuss JO, Cheng QJ, Arvai AS, Hammel M, Roberts VA, et al. (May 2008).
2959:
852:– Discovery of seven conserved amino acid domains determined to be helicase motifs
4694:. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press. pp. 545–574.
4379:
4362:
4265:"RNA helicases: emerging roles in viral replication and the host innate response"
2804:
8095:
8030:
7866:
7710:
6729:
6719:
6320:
6057:
5998:
5385:
1478:
1343:
876:– Isolation of the first reported mitochondrial DNA helicase (from bovine brain)
167:
8123:
4648:
4586:
Proceedings of the National Academy of Sciences of the United States of America
4541:"The gene 4 protein of bacteriophage T7. Characterization of helicase activity"
4408:
Proceedings of the National Academy of Sciences of the United States of America
4329:
4085:
Proceedings of the National Academy of Sciences of the United States of America
3925:"Atomic models for the polypeptide backbones of myohemerythrin and hemerythrin"
3253:
2525:
Proceedings of the National Academy of Sciences of the United States of America
2008:
1902:
1812:
1729:
Proceedings of the National Academy of Sciences of the United States of America
1188:
or a homologous non-sister chromatid as template. This repair can result in a
822:– Discovery of the first eukaryotic DNA helicases, isolated from the lily plant
7695:
7384:
6531:
6374:
6287:
6052:
6002:
5770:
5591:
5538:
5530:
5471:
5445:
5233:
5218:
3596:
3493:
2899:
2746:
1723:
Lionnet T, Spiering MM, Benkovic SJ, Bensimon D, Croquette V (December 2007).
1546:
1470:
1161:, is characterized by premature aging, skin and skeletal abnormalities, rash,
1007:
932:
921:
902:
115:
88:
4709:
3948:
3835:
3022:
2487:
2429:
2290:
8069:
8043:
7401:
6960:
6810:
6723:
6260:
6026:
5409:
5223:
5213:
4606:
4428:
4105:
3995:
3451:
3056:
3039:
2545:
2039:
Wu, C. G. and Spies, M.: Overview: What are Helicases? In: Spies, M. (Ed.):
1847:
1749:
1177:
151:
17:
4676:
4625:
4496:
4447:
4388:
4347:
4298:
4224:
4180:
4124:
4062:
4013:
3853:
3786:
3705:
3604:
3569:
3560:
3543:
3511:
3359:
3315:
3271:
3193:
3144:
3121:
3102:
2951:
2907:
2872:
2823:
2764:
2708:
2640:
2259:
2026:
1962:
1830:
1768:
1709:
1700:
1683:
1665:
1611:
1192:(CO) or, more frequently, a non-crossover (NCO) recombinant. In the yeast
1119:
80:
4641:
Single-Molecule Enzymology: Fluorescence-Based and High-Throughput Methods
4566:
4280:
4162:
4044:
3826:
3743:
3653:
3459:
3405:
3175:
3065:
3005:
2605:
2564:
2505:
2447:
2398:
2357:
2308:
2207:
2040:
1592:
6657:
6237:
5486:
5467:
5030:
3687:
2161:
2123:
1944:
1542:
1409:
1253:
1252:
RNA helicases are essential for most processes of RNA metabolism such as
1150:
plays a role in rescuing disrupted DNA replication at replication forks.
566:
217:
52:
3970:
Lorenz A, Osman F, Sun W, Nandi S, Steinacher R, Whitby MC (June 2012).
2839:"Common origin of four diverse families of large eukaryotic DNA viruses"
2371:
Sugino A, Ryu BH, Sugino T, Naumovski L, Friedberg EC (September 1986).
2153:
7806:
7775:
7553:
7548:
7307:
7297:
7272:
7267:
7002:
6608:
6593:
6209:
5798:
5550:
5050:
5025:
5020:
4852:
3735:
1538:
1169:
828:– "T4 gene 41 protein" is the first reported bacteriophage DNA helicase
562:
233:
Helicase (blue triangle) separates the intertwined DNA strands so that
211:
202:
198:
4215:
4198:
1647:
8082:
7852:
7683:
7325:
7302:
7292:
7262:
7257:
7252:
7247:
7204:
7194:
7189:
7184:
7179:
7148:
7136:
7131:
7126:
7121:
7109:
7104:
7099:
7048:
6586:
6021:
5923:
5678:
5631:
5626:
3397:
1550:
1207:
1131:
336:{\displaystyle B=N(\Delta G_{\text{bp}}-G_{\text{int}}-G_{\text{f}})}
48:
4478:
3956:
3924:
3810:"Maintenance of Yeast Genome Integrity by RecQ Family DNA Helicases"
2943:
2053:"Kevin Ahern's Biochemistry (BB 451/551) at Oregon State University"
30:
3628:"The Bloom's syndrome gene product is homologous to RecQ helicases"
2930:
Ropers HH, Hamel BC (January 2005). "X-linked mental retardation".
2470:
Tuteja N, Tuteja R, Rahman K, Kang LY, Falaschi A (December 1990).
8056:
7739:
7678:
7661:
7656:
7504:
7482:
7448:
7443:
7428:
7406:
7394:
7389:
7379:
7374:
7369:
7094:
7070:
6603:
6598:
6450:
5938:
5933:
5928:
5918:
5911:
5906:
5901:
5896:
5891:
5881:
5876:
5731:
5695:
5616:
5611:
5606:
5596:
5400:
5395:
5390:
5373:
5368:
5363:
5358:
5346:
5341:
5059:
5054:
5011:
5006:
5001:
1534:
1526:
1514:
1494:
1474:
1466:
1461:
1441:
1433:
1429:
1417:
1372:
1242:
1234:
1199:
1118:
1091:
1072:
29:
6760:
CDP-diacylglycerol—glycerol-3-phosphate 3-phosphatidyltransferase
3778:
158:. Metabolic processes of RNA such as translation, transcription,
7744:
7700:
7688:
7673:
7639:
7634:
7619:
7602:
7597:
7592:
7580:
7575:
7570:
7560:
7536:
7531:
7526:
7521:
7423:
6514:
6509:
6405:
6400:
6099:
6094:
6089:
5824:
5780:
5775:
5710:
5705:
5700:
5673:
5653:
5648:
5601:
5282:
5206:
5201:
5196:
5191:
5186:
5181:
5176:
5171:
5166:
5161:
5156:
5151:
5043:
4973:
4968:
4963:
4958:
4953:
4948:
4936:
4929:
4920:
4915:
4910:
4905:
4900:
4895:
4857:
4833:
4821:
3808:
Gupta, Sonia Vidushi; Schmidt, Kristina Hildegard (2020-02-18).
3158:
Rudolf J, Rouillon C, Schwarz-Linek U, White MF (January 2010).
1522:
1518:
1510:
1506:
1449:
1445:
1425:
1421:
1404:
1400:
1396:
1388:
1384:
1380:
1376:
1368:
1322:
1043:
7825:
6933:
5971:
5503:
4749:
4361:
Yang Q, Del Campo M, Lambowitz AM, Jankowsky E (October 2007).
2412:
Gorbalenya AE, Koonin EV, Donchenko AP, Blinov VM (June 1989).
935:
sequence is related to the specific features of each helicase.
7794:
7790:
5586:
5581:
4690:
Borowiec JA (1996). "DNA Helicases". In DePamphilis ML (ed.).
4518:
4363:"DEAD-box proteins unwind duplexes by local strand separation"
960:
956:
952:
858:– Designation of DNA helicase Superfamily I and Superfamily II
194:
139:
132:
56:
5499:
4242:. Cambridge, England: Royal Society of Chemistry. p. 5.
846:– ATPaseIII, a yeast protein, determined to be a DNA helicase
1927:
Manosas M, Xi XG, Bensimon D, Croquette V (September 2010).
1795:
Johnson DS, Bai L, Smith BY, Patel SS, Wang MD (June 2007).
2978:
Gibbons RJ, Picketts DJ, Villard L, Higgs DR (March 1995).
2729:
Fairman-Williams ME, Guenther UP, Jankowsky E (June 2010).
1210:
intermediates, promote NCO recombination by the process of
7821:
3544:"Junction of RecQ helicase biochemistry and human disease"
3292:. Methods in Enzymology. Vol. 408. pp. 246–263.
2096:
Abdel-Monem M, Dürwald H, Hoffmann-Berling H (June 1976).
1099:
aging seen in trichothiodystrophy and Cockayne syndrome.
834:– First mammalian DNA helicases isolated from calf thymus
4027:
Lorenz A, Mehats A, Osman F, Whitby MC (December 2014).
74:, separating two hybridized nucleic acid strands (hence
4643:. Methods in Enzymology. Vol. 581. pp. 1–32.
2778:
Stelter M, Acajjaoui S, McSweeney S, Timmins J (2013).
1848:"Researchers solve mystery of how DNA strands separate"
1632:"Genome-wide comprehensive analysis of human helicases"
146:
hydrolysis, a process characterized by the breaking of
4145:
Jankowsky A, Guenther UP, Jankowsky E (January 2011).
1993:
single-molecule manipulation data analysis and models"
1309:
Various methods are used to measure helicase activity
1010:
proteins conform the SF5 group. They have a RecA fold.
8112:
6770:
CDP-diacylglycerol—inositol 3-phosphatidyltransferase
1339:
helicase can break per hydrolysis of 1 ATP molecule.
767:
740:
710:
683:
647:
605:
575:
546:
515:
479:
438:
409:
377:
355:
278:
255:
6775:
CDP-diacylglycerol—choline O-phosphatidyltransferase
1576:"Unwinding and rewinding: double faces of helicase?"
8008:
7972:
7941:
7910:
7859:
7760:
7719:
7459:
7333:
7320:
7285:
7237:
7218:
7164:
7084:
7063:
7056:
7039:
7016:
6976:
6894:
6872:
6847:
6822:
6803:
6783:
6765:
CDP-diacylglycerol—serine O-phosphatidyltransferase
6752:
6742:
6712:
6694:
6671:
6643:
6542:
6382:
6373:
6350:
6310:
6255:
6232:
6204:
6038:
6014:
5812:
5791:
5719:
5664:
5537:
5458:
5432:
5262:
5133:
5124:
5068:
4868:
4801:
4792:
4539:Matson SW, Tabor S, Richardson CC (November 1983).
4463:"DEAD-box proteins as RNA helicases and chaperones"
3929:
Biochemical and Biophysical Research Communications
3332:Tirode F, Busso D, Coin F, Egly JM (January 1999).
3139:. Seattle (WA): University of Washington, Seattle.
2324:"DNA helicase activity of SV40 large tumor antigen"
2180:Venkatesan M, Silver LL, Nossal NG (October 1982).
459:= reduction of free energy due to unzipping forces.
2175:
2173:
2171:
1997:Computational and Structural Biotechnology Journal
780:
753:
723:
696:
669:
630:
591:
552:
528:
501:
451:
422:
393:
361:
335:
261:
131:Helicases are often used to separate strands of a
3086:"Alpha thalassaemia-mental retardation, X linked"
55:. Their main function is to unpack an organism's
4314:"RNA helicases at work: binding and rearranging"
1872:
1870:
1868:
1866:
1864:
864:– Identification of the DEAD box helicase family
201:, other enzymes have been shown to be active as
4074:
4072:
3478:"Molecular genetics of RecQ helicase disorders"
3079:
3077:
3075:
2837:Iyer LM, Aravind L, Koonin EV (December 2001).
2219:
2217:
430:= reduction of free energy due to helicase, and
4402:Liu F, Putnam A, Jankowsky E (December 2008).
4140:
4138:
4136:
4134:
3923:Hendrickson, W. A.; Ward, K. B. (1975-10-27).
2973:
2971:
2969:
1982:
1980:
1978:
1976:
1974:
1972:
1790:
1788:
1786:
1784:
1782:
1780:
1778:
27:Class of enzymes to unpack an organism's genes
7837:
6945:
5983:
5515:
4761:
2682:
2680:
2678:
2676:
2674:
2672:
2670:
8:
3542:Opresko PL, Cheng WH, Bohr VA (April 2004).
3425:
3423:
2668:
2666:
2664:
2662:
2660:
2658:
2656:
2654:
2652:
2650:
2322:Stahl H, Dröge P, Knippers R (August 1986).
1929:"Active and passive mechanisms of helicases"
1630:Umate P, Tuteja N, Tuteja R (January 2011).
6791:N-acetylglucosamine-1-phosphate transferase
6681:UTP—glucose-1-phosphate uridylyltransferase
4580:Sarlós K, Gyimesi M, Kovács M (June 2012).
4192:
4190:
3033:
3031:
3017:
3015:
2042:. Springer Science+Business Media, NY, 2013
1987:Jarillo J, Ibarra B, Cao-García FJ (2021).
1677:
1675:
7844:
7830:
7822:
7330:
7060:
7053:
6952:
6938:
6930:
6819:
6749:
6379:
6370:
6035:
5990:
5976:
5968:
5522:
5508:
5500:
5130:
4798:
4768:
4754:
4746:
3908:) CS1 maint: numeric names: authors list (
3537:
3535:
3533:
3531:
3529:
2724:
2722:
2720:
2718:
2521:"DNA helicase from mammalian mitochondria"
2519:Hehman GL, Hauswirth WW (September 1992).
1842:
1840:
1305:Measuring and monitoring helicase activity
1024:All helicases are members of a P-loop, or
599:) is less than the rate of translocation (
226:
6885:serine/threonine-specific protein kinases
6863:serine/threonine-specific protein kinases
6686:Galactose-1-phosphate uridylyltransferase
4738:at the U.S. National Library of Medicine
4728:at the U.S. National Library of Medicine
4666:
4615:
4605:
4556:
4486:
4437:
4427:
4378:
4337:
4288:
4240:RNA Helicases (RSC Biomolecular Sciences)
4214:
4170:
4114:
4104:
4052:
4003:
3904:CS1 maint: multiple names: authors list (
3843:
3825:
3695:
3643:
3559:
3501:
3471:
3469:
3349:
3327:
3325:
3261:
3183:
3111:
3101:
3055:
2995:
2925:
2923:
2921:
2919:
2917:
2862:
2813:
2803:
2754:
2595:
2578:Tuteja N, Phan TN, Tewari KK (May 1996).
2554:
2544:
2495:
2437:
2388:
2347:
2298:
2249:
2197:
2113:
2016:
1952:
1922:
1920:
1918:
1916:
1914:
1912:
1820:
1758:
1748:
1699:
1655:
1601:
1591:
1300:Diagnostic tools for helicase measurement
1157:Rothmund-Thomson syndrome, also known as
772:
766:
745:
739:
715:
709:
688:
682:
658:
646:
610:
604:
580:
574:
545:
520:
514:
490:
478:
443:
437:
414:
408:
385:
376:
354:
324:
311:
298:
277:
254:
185:Helicases adopt different structures and
4199:"RNA helicases in infection and disease"
3665:
3663:
3283:
3281:
2701:10.1146/annurev.biochem.76.052305.115300
2135:
2133:
2091:
2089:
959:and β helicases work with double-strand
8119:
4197:Steimer L, Klostermeier D (June 2012).
3717:
3715:
3476:Hanada K, Hickson ID (September 2007).
3371:
3369:
3231:
3229:
3227:
3225:
3223:
3023:" ATRX-Transcriptional regulator ATRX."
2731:"SF1 and SF2 helicases: family matters"
1877:Betterton MD, Jülicher F (2005-08-31).
1636:Communicative & Integrative Biology
1625:
1623:
1621:
1566:
1317:Strand displacement assay involves the
245:Activation barrier in helicase activity
3894:
3882:
3871:
3221:
3219:
3217:
3215:
3213:
3211:
3209:
3207:
3205:
3203:
2621:Molecular and Biochemical Parasitology
2273:Hübscher U, Stalder HP (August 1985).
1336:fluorescence resonance energy transfer
1279:lethal congenital contracture syndrome
955:; α helicases work with single-strand
2735:Current Opinion in Structural Biology
1090:XPD is an essential component of the
401:= free energy of base pair formation,
369:= number of unwound base pairs (bps),
7:
4467:Wiley Interdisciplinary Reviews. RNA
3585:Mechanisms of Ageing and Development
3482:Cellular and Molecular Life Sciences
2080:3-D Animation Library; Replication:
1212:synthesis-dependent strand annealing
394:{\displaystyle \Delta G_{\text{bp}}}
182:specific to each particular enzyme.
4692:DNA Replication in Eukaryotic Cells
4545:The Journal of Biological Chemistry
3548:The Journal of Biological Chemistry
2377:The Journal of Biological Chemistry
2186:The Journal of Biological Chemistry
1688:The Journal of Biological Chemistry
1256:biogenesis, pre-mRNA splicing, and
1172:DNA double-strand breaks and other
870:– Isolation of a human DNA helicase
5830:Proliferating Cell Nuclear Antigen
5761:Microhomology-mediated end joining
3021:Nextprot Online Protein Database.
2855:10.1128/JVI.75.23.11720-11734.2001
2340:10.1002/j.1460-2075.1986.tb04447.x
2115:10.1111/j.1432-1033.1976.tb10359.x
670:{\displaystyle B<k_{\text{B}}T}
502:{\displaystyle B>k_{\text{B}}T}
378:
291:
25:
6196:Glucose-1,6-bisphosphate synthase
5424:Control of chromosome duplication
4990:Autonomously replicating sequence
4461:Jarmoskaite I, Russell R (2011).
3090:Orphanet Journal of Rare Diseases
2472:"A DNA helicase from human cells"
912:located in the interior of their
800:DNA helicases were discovered in
8122:
6337:Ribose-phosphate diphosphokinase
5952:
5951:
5845:Meiotic recombination checkpoint
4263:Ranji A, Boris-Lawrie K (2010).
3025:, Retrieved on 12 November 2012.
2597:10.1111/j.1432-1033.1996.0054q.x
2584:European Journal of Biochemistry
2242:10.1111/j.1432-1033.2004.04093.x
2230:European Journal of Biochemistry
2102:European Journal of Biochemistry
1682:Patel SS, Donmez I (July 2006).
978:bacteria and PcrA helicase from
781:{\displaystyle V_{\text{trans}}}
724:{\displaystyle V_{\text{trans}}}
2224:Tuteja N, Tuteja R (May 2004).
1032:Helicase disorders and diseases
561:decrease unwinding rates (i.e.
142:molecule using the energy from
4318:Trends in Biochemical Sciences
1367:helicase DNA binding protein:
931:. The variable portion of the
423:{\displaystyle G_{\text{int}}}
330:
288:
1:
6910:Protein-histidine tele-kinase
6905:Protein-histidine pros-kinase
6784:Glycosyl-1-phosphotransferase
5147:DNA polymerase III holoenzyme
4997:Single-strand binding protein
4558:10.1016/S0021-9258(17)44018-X
4157:(Database issue): D338–D341.
3351:10.1016/S1097-2765(00)80177-X
3298:10.1016/S0076-6879(06)08015-3
2888:Journal of Structural Biology
2689:Annual Review of Biochemistry
2633:10.1016/S0166-6851(02)00205-0
2390:10.1016/S0021-9258(18)67306-5
2199:10.1016/S0021-9258(18)33731-1
1350:Determining helicase polarity
1332:scintillation proximity assay
1271:spinocerebellar ataxia type-2
1263:amyotrophic lateral sclerosis
812:– Discovery and isolation of
754:{\displaystyle V_{\text{un}}}
697:{\displaystyle V_{\text{un}}}
6616:RNA-dependent RNA polymerase
5727:Transcription-coupled repair
4380:10.1016/j.molcel.2007.08.016
4312:Jankowsky E (January 2011).
3941:10.1016/0006-291x(75)90508-2
3645:10.1016/0092-8674(95)90105-1
2997:10.1016/0092-8674(95)90287-2
2805:10.1371/journal.pone.0077364
1068:XPD helicase point mutations
924:and translocation along the
529:{\displaystyle k_{\text{B}}}
468:Active and passive helicases
452:{\displaystyle G_{\text{f}}}
174:strand of the duplex with a
7722:Protein-synthesizing GTPase
6523:RNA-directed DNA polymerase
6391:DNA-directed DNA polymerase
4147:"The RNA helicase database"
1239:Human DEAD-box RNA helicase
51:thought to be vital to all
8171:
6876:: protein-dual-specificity
5749:Non-homologous end joining
5573:Nucleotide excision repair
5566:Poly ADP ribose polymerase
5243:Prokaryotic DNA polymerase
4944:Minichromosome maintenance
4891:Origin recognition complex
4649:10.1016/bs.mie.2016.09.010
4330:10.1016/j.tibs.2010.07.008
3254:10.1016/j.cell.2008.04.030
2009:10.1016/j.csbj.2021.06.032
1903:10.1103/PhysRevE.72.029906
1813:10.1016/j.cell.2007.04.038
1096:nucleotide excision repair
8000:Michaelis–Menten kinetics
7781:Guanylate-binding protein
6965:acid anhydride hydrolases
5947:
5321:Eukaryotic DNA polymerase
3597:10.1016/j.mad.2008.03.003
3494:10.1007/s00018-007-7121-z
2900:10.1016/j.jsb.2003.10.010
2747:10.1016/j.sbi.2010.03.011
1684:"Mechanisms of helicases"
1195:Schizosaccharomyces pombe
1140:Rothmund–Thomson syndrome
1050:heterochromatin protein 1
788:are approximately equal.
631:{\displaystyle V_{trans}}
235:daughter strands can form
152:annealed nucleotide bases
7892:Diffusion-limited enzyme
7336:Heterotrimeric G protein
7031:Phosphoadenylylsulfatase
6853:protein-serine/threonine
6753:Phosphatidyltransferases
6342:Thiamine diphosphokinase
5744:Homology directed repair
5666:Homologous recombination
4740:Medical Subject Headings
4730:Medical Subject Headings
3044:Human Molecular Genetics
2932:Nature Reviews. Genetics
2275:"Mammalian DNA helicase"
1580:Journal of Nucleic Acids
1182:homologous recombination
1159:poikiloderma congenitale
796:History of DNA helicases
7008:Thiamine-triphosphatase
4884:Pre-replication complex
4815:Pre-replication complex
4607:10.1073/pnas.1114468109
4429:10.1073/pnas.0811115106
4106:10.1073/pnas.1423107112
3996:10.1126/science.1220111
3868:10.3390/genes11060622].
3452:10.1126/science.8465201
2546:10.1073/pnas.89.18.8562
1750:10.1073/pnas.0709793104
1291:DEAD/DEAH box helicases
1267:spinal muscular atrophy
1037:ATRX helicase mutations
1020:, RuvB, RuvA, and RuvC.
193:-like helicases unwind
72:phosphodiester backbone
6673:Nucleotidyltransferase
6356:nucleotidyltransferase
6283:Nucleoside-diphosphate
5766:Postreplication repair
5561:Uracil-DNA glycosylase
4151:Nucleic Acids Research
4033:Nucleic Acids Research
3881:Cite journal requires
3676:Nucleic Acids Research
3561:10.1074/jbc.R300034200
3164:Nucleic Acids Research
3103:10.1186/1750-1172-1-15
3084:Gibbons R (May 2006).
2488:10.1093/nar/18.23.6785
2476:Nucleic Acids Research
2430:10.1093/nar/17.12.4713
2418:Nucleic Acids Research
2291:10.1093/nar/13.15.5471
2279:Nucleic Acids Research
1933:Nucleic Acids Research
1701:10.1074/jbc.R600008200
1414:DEAD/DEAH box helicase
1249:
1240:
1124:
782:
755:
725:
698:
671:
632:
593:
592:{\displaystyle V_{un}}
554:
530:
503:
453:
424:
395:
363:
337:
263:
41:
7985:Eadie–Hofstee diagram
7918:Allosteric regulation
7763:Polymerization motors
7474:Rho family of GTPases
6527:Reverse transcriptase
5307:Replication protein A
5076:Origin of replication
4281:10.4161/rna.7.6.14249
3827:10.3390/genes11020205
3057:10.1093/hmg/5.12.1899
1556:RNA helicase database
1246:
1238:
1122:
1115:RecQ family mutations
1085:xeroderma pigmentosum
783:
756:
726:
699:
672:
641:In active helicases,
633:
594:
555:
531:
504:
454:
425:
396:
364:
338:
264:
84:), using energy from
33:
7995:Lineweaver–Burk plot
6316:diphosphotransferase
6298:Thiamine-diphosphate
6005:-containing groups (
5872:core protein complex
5547:Base excision repair
5278:Replication factor C
1323:PAGE electrophoresis
1220:Arabidopsis thaliana
1146:(WS), respectively.
1028:-containing family.
890:Plasmodium cynomolgi
765:
738:
708:
681:
645:
603:
573:
544:
513:
477:
436:
407:
375:
353:
276:
253:
7771:dynamin superfamily
6898:: protein-histidine
6816:; protein acceptor)
6704:mRNA capping enzyme
6696:Guanylyltransferase
5644:DNA mismatch repair
4598:2012PNAS..109.9804S
4551:(22): 14017–14024.
4515:www.rnahelicase.org
4420:2008PNAS..10520209L
4414:(51): 20209–20214.
4163:10.1093/nar/gkq1002
4097:2015PNAS..112.4713S
4045:10.1093/nar/gku1219
4039:(22): 13723–13735.
3988:2012Sci...336.1585L
3982:(6088): 1585–1588.
3554:(18): 18099–18102.
3444:1993Sci...260...58S
3390:1993Natur.365..852S
3176:10.1093/nar/gkp1058
2849:(23): 11720–11734.
2843:Journal of Virology
2796:2013PLoSO...877364S
2537:1992PNAS...89.8562H
2383:(25): 11744–11750.
2192:(20): 12426–12434.
2154:10.1021/bi00603a011
1895:2005PhRvE..72b9906B
1741:2007PNAS..10419790L
1735:(50): 19790–19795.
1694:(27): 18265–18268.
1593:10.1155/2012/140601
1081:trichothiodystrophy
1014:Superfamily 6 (SF6)
1004:Superfamily 5 (SF5)
998:Superfamily 4 (SF4)
992:Superfamily 3 (SF3)
986:Superfamily 2 (SF2)
968:Superfamily 1 (SF1)
908:; they all possess
897:Structural features
816:-based DNA helicase
160:ribosome biogenesis
138:or a self-annealed
120:ribosome biogenesis
7954:Enzyme superfamily
7887:Enzyme promiscuity
6174:Phosphoinositide 3
6018:phosphotransferase
3736:10.1038/ng0997-100
3688:10.1093/nar/gkn498
3290:DNA Repair, Part A
1989:"DNA replication:
1945:10.1093/nar/gkq273
1334:, a time resolved
1250:
1241:
1204:RecQ-type helicase
1125:
778:
751:
721:
694:
667:
628:
589:
550:
538:Boltzmann constant
526:
499:
449:
420:
391:
359:
333:
259:
42:
8110:
8109:
7819:
7818:
7815:
7814:
7316:
7315:
7281:
7280:
7026:Adenylylsulfatase
6927:
6926:
6923:
6922:
6799:
6798:
6738:
6737:
6639:
6638:
6552:Template-directed
6306:
6305:
6273:Phosphomevalonate
5965:
5964:
5840:Adaptive response
5497:
5496:
5454:
5453:
5290:Flap endonuclease
5120:
5119:
5107:Okazaki fragments
4701:978-0-87969-459-3
4592:(25): 9804–9809.
4249:978-1-84755-914-2
4216:10.4161/rna.20090
4091:(15): 4713–4718.
3893:Missing or empty
3682:(16): 5166–5179.
3488:(17): 2306–2322.
3384:(6449): 852–855.
3050:(12): 1899–1907.
2531:(18): 8562–8566.
2482:(23): 6785–6792.
2424:(12): 4713–4730.
2285:(15): 5471–5483.
2236:(10): 1835–1848.
2148:(10): 1872–1880.
1939:(16): 5518–5526.
1883:Physical Review E
1648:10.4161/cib.13844
1275:Alzheimer disease
1225:natural selection
1184:using either the
1077:Cockayne syndrome
951:or double-strand
914:primary structure
906:sequence homology
775:
748:
718:
691:
661:
553:{\displaystyle T}
523:
493:
446:
417:
388:
362:{\displaystyle N}
327:
314:
301:
262:{\displaystyle B}
166:, RNA transport,
156:DNA recombination
16:(Redirected from
8162:
8127:
8126:
8118:
7990:Hanes–Woolf plot
7933:Enzyme activator
7928:Enzyme inhibitor
7902:Enzyme catalysis
7846:
7839:
7832:
7823:
7331:
7061:
7054:
6954:
6947:
6940:
6931:
6915:Histidine kinase
6838:tyrosine kinases
6828:protein-tyrosine
6820:
6750:
6557:RNA polymerase I
6380:
6371:
6224:Aspartate kinase
6219:Phosphoglycerate
6036:
5992:
5985:
5978:
5969:
5955:
5954:
5524:
5517:
5510:
5501:
5247:DNA polymerase I
5131:
5091:Replication fork
4983:Licensing factor
4799:
4770:
4763:
4756:
4747:
4714:
4713:
4687:
4681:
4680:
4670:
4636:
4630:
4629:
4619:
4609:
4577:
4571:
4570:
4560:
4536:
4530:
4529:
4527:
4526:
4517:. Archived from
4507:
4501:
4500:
4490:
4458:
4452:
4451:
4441:
4431:
4399:
4393:
4392:
4382:
4358:
4352:
4351:
4341:
4309:
4303:
4302:
4292:
4260:
4254:
4253:
4235:
4229:
4228:
4218:
4194:
4185:
4184:
4174:
4142:
4129:
4128:
4118:
4108:
4076:
4067:
4066:
4056:
4024:
4018:
4017:
4007:
3967:
3961:
3960:
3935:(4): 1349–1356.
3920:
3914:
3913:
3902:
3896:
3890:
3884:
3879:
3877:
3869:
3864:
3858:
3857:
3847:
3829:
3805:
3799:
3798:
3762:
3756:
3755:
3719:
3710:
3709:
3699:
3667:
3658:
3657:
3647:
3623:
3617:
3616:
3591:(7–8): 425–440.
3580:
3574:
3573:
3563:
3539:
3524:
3523:
3505:
3473:
3464:
3463:
3427:
3418:
3417:
3398:10.1038/365852a0
3373:
3364:
3363:
3353:
3329:
3320:
3319:
3285:
3276:
3275:
3265:
3233:
3198:
3197:
3187:
3155:
3149:
3148:
3132:
3126:
3125:
3115:
3105:
3081:
3070:
3069:
3059:
3035:
3026:
3019:
3010:
3009:
2999:
2975:
2964:
2963:
2927:
2912:
2911:
2883:
2877:
2876:
2866:
2834:
2828:
2827:
2817:
2807:
2775:
2769:
2768:
2758:
2726:
2713:
2712:
2684:
2645:
2644:
2616:
2610:
2609:
2599:
2575:
2569:
2568:
2558:
2548:
2516:
2510:
2509:
2499:
2467:
2461:
2458:
2452:
2451:
2441:
2409:
2403:
2402:
2392:
2368:
2362:
2361:
2351:
2334:(8): 1939–1944.
2328:The EMBO Journal
2319:
2313:
2312:
2302:
2270:
2264:
2263:
2253:
2221:
2212:
2211:
2201:
2177:
2166:
2165:
2137:
2128:
2127:
2117:
2093:
2084:
2078:
2072:
2071:
2069:
2068:
2059:. Archived from
2049:
2043:
2037:
2031:
2030:
2020:
1984:
1967:
1966:
1956:
1924:
1907:
1906:
1874:
1859:
1858:
1856:
1855:
1844:
1835:
1834:
1824:
1807:(7): 1299–1309.
1792:
1773:
1772:
1762:
1752:
1720:
1714:
1713:
1703:
1679:
1670:
1669:
1659:
1627:
1616:
1615:
1605:
1595:
1571:
1186:sister chromatid
1180:are repaired by
940:Conserved motifs
787:
785:
784:
779:
777:
776:
773:
760:
758:
757:
752:
750:
749:
746:
730:
728:
727:
722:
720:
719:
716:
703:
701:
700:
695:
693:
692:
689:
676:
674:
673:
668:
663:
662:
659:
637:
635:
634:
629:
627:
626:
598:
596:
595:
590:
588:
587:
559:
557:
556:
551:
535:
533:
532:
527:
525:
524:
521:
508:
506:
505:
500:
495:
494:
491:
458:
456:
455:
450:
448:
447:
444:
429:
427:
426:
421:
419:
418:
415:
400:
398:
397:
392:
390:
389:
386:
368:
366:
365:
360:
342:
340:
339:
334:
329:
328:
325:
316:
315:
312:
303:
302:
299:
268:
266:
265:
260:
230:
189:states. Whereas
59:. Helicases are
57:genetic material
21:
8170:
8169:
8165:
8164:
8163:
8161:
8160:
8159:
8150:DNA replication
8135:
8134:
8133:
8121:
8113:
8111:
8106:
8018:Oxidoreductases
8004:
7980:Enzyme kinetics
7968:
7964:List of enzymes
7937:
7906:
7877:Catalytic triad
7855:
7850:
7820:
7811:
7756:
7715:
7466:Ras superfamily
7455:
7439:
7419:
7365:
7355:
7347:
7312:
7277:
7233:
7214:
7160:
7117:Plasma membrane
7080:
7035:
7012:
6986:Pyrophosphatase
6972:
6958:
6928:
6919:
6890:
6868:
6843:
6814:
6808:
6804:2.7.10-2.7.13:
6795:
6779:
6746:: miscellaneous
6734:
6708:
6690:
6667:
6650:exoribonuclease
6647:
6635:
6621:Polyadenylation
6538:
6364:
6358:
6346:
6328:
6324:
6318:
6302:
6264:
6251:
6228:
6200:
6030:
6024:
6016:
6010:
5996:
5966:
5961:
5943:
5813:Other/ungrouped
5808:
5787:
5715:
5660:
5556:DNA glycosylase
5539:Excision repair
5533:
5528:
5498:
5493:
5450:
5428:
5268:
5264:
5258:
5252:Klenow fragment
5135:
5116:
5100:leading strands
5064:
4874:
4870:
4864:
4803:
4788:
4777:DNA replication
4774:
4722:
4717:
4702:
4689:
4688:
4684:
4659:
4638:
4637:
4633:
4579:
4578:
4574:
4538:
4537:
4533:
4524:
4522:
4509:
4508:
4504:
4479:10.1002/wrna.50
4460:
4459:
4455:
4401:
4400:
4396:
4360:
4359:
4355:
4311:
4310:
4306:
4262:
4261:
4257:
4250:
4237:
4236:
4232:
4196:
4195:
4188:
4144:
4143:
4132:
4078:
4077:
4070:
4026:
4025:
4021:
3969:
3968:
3964:
3922:
3921:
3917:
3903:
3892:
3880:
3870:
3866:
3865:
3861:
3807:
3806:
3802:
3767:Nature Genetics
3764:
3763:
3759:
3724:Nature Genetics
3721:
3720:
3713:
3669:
3668:
3661:
3625:
3624:
3620:
3582:
3581:
3577:
3541:
3540:
3527:
3475:
3474:
3467:
3438:(5104): 58–63.
3429:
3428:
3421:
3375:
3374:
3367:
3331:
3330:
3323:
3308:
3287:
3286:
3279:
3235:
3234:
3201:
3157:
3156:
3152:
3134:
3133:
3129:
3083:
3082:
3073:
3037:
3036:
3029:
3020:
3013:
2977:
2976:
2967:
2944:10.1038/nrg1501
2929:
2928:
2915:
2885:
2884:
2880:
2836:
2835:
2831:
2777:
2776:
2772:
2728:
2727:
2716:
2686:
2685:
2648:
2618:
2617:
2613:
2577:
2576:
2572:
2518:
2517:
2513:
2469:
2468:
2464:
2459:
2455:
2411:
2410:
2406:
2370:
2369:
2365:
2321:
2320:
2316:
2272:
2271:
2267:
2223:
2222:
2215:
2179:
2178:
2169:
2139:
2138:
2131:
2095:
2094:
2087:
2079:
2075:
2066:
2064:
2057:oregonstate.edu
2051:
2050:
2046:
2038:
2034:
1986:
1985:
1970:
1926:
1925:
1910:
1876:
1875:
1862:
1853:
1851:
1846:
1845:
1838:
1794:
1793:
1776:
1722:
1721:
1717:
1681:
1680:
1673:
1629:
1628:
1619:
1573:
1572:
1568:
1564:
1361:
1352:
1307:
1302:
1233:
1144:Werner syndrome
1117:
1070:
1039:
1034:
948:
910:sequence motifs
899:
798:
768:
763:
762:
741:
736:
735:
711:
706:
705:
684:
679:
678:
654:
643:
642:
606:
601:
600:
576:
571:
570:
542:
541:
516:
511:
510:
486:
475:
474:
470:
439:
434:
433:
410:
405:
404:
381:
373:
372:
351:
350:
320:
307:
294:
274:
273:
251:
250:
247:
242:
241:
240:
239:
238:
197:as ring-shaped
187:oligomerization
129:
100:DNA replication
47:are a class of
28:
23:
22:
15:
12:
11:
5:
8168:
8166:
8158:
8157:
8152:
8147:
8137:
8136:
8132:
8131:
8108:
8107:
8105:
8104:
8091:
8078:
8065:
8052:
8039:
8026:
8012:
8010:
8006:
8005:
8003:
8002:
7997:
7992:
7987:
7982:
7976:
7974:
7970:
7969:
7967:
7966:
7961:
7956:
7951:
7945:
7943:
7942:Classification
7939:
7938:
7936:
7935:
7930:
7925:
7920:
7914:
7912:
7908:
7907:
7905:
7904:
7899:
7894:
7889:
7884:
7879:
7874:
7869:
7863:
7861:
7857:
7856:
7851:
7849:
7848:
7841:
7834:
7826:
7817:
7816:
7813:
7812:
7810:
7809:
7804:
7803:
7802:
7797:
7788:
7783:
7778:
7767:
7765:
7758:
7757:
7755:
7754:
7749:
7748:
7747:
7742:
7737:
7726:
7724:
7717:
7716:
7714:
7713:
7708:
7703:
7698:
7693:
7692:
7691:
7686:
7681:
7676:
7666:
7665:
7664:
7659:
7649:
7648:
7647:
7642:
7637:
7625:
7624:
7623:
7622:
7617:
7607:
7606:
7605:
7600:
7595:
7585:
7584:
7583:
7578:
7573:
7563:
7558:
7557:
7556:
7551:
7541:
7540:
7539:
7534:
7529:
7524:
7514:
7513:
7512:
7507:
7497:
7496:
7495:
7490:
7485:
7470:
7468:
7457:
7456:
7454:
7453:
7452:
7451:
7446:
7437:
7433:
7432:
7431:
7426:
7417:
7413:
7412:
7411:
7410:
7409:
7399:
7398:
7397:
7392:
7382:
7377:
7372:
7363:
7359:
7358:
7357:
7353:
7345:
7340:
7338:
7328:
7318:
7317:
7314:
7313:
7311:
7310:
7305:
7300:
7295:
7289:
7287:
7283:
7282:
7279:
7278:
7276:
7275:
7270:
7265:
7260:
7255:
7250:
7244:
7242:
7235:
7234:
7232:
7231:
7225:
7223:
7216:
7215:
7213:
7212:
7207:
7202:
7197:
7192:
7187:
7182:
7177:
7171:
7169:
7162:
7161:
7159:
7158:
7157:
7156:
7151:
7141:
7140:
7139:
7134:
7129:
7124:
7114:
7113:
7112:
7107:
7102:
7091:
7089:
7082:
7081:
7079:
7078:
7073:
7067:
7065:
7064:Cu++ (3.6.3.4)
7058:
7051:
7037:
7036:
7034:
7033:
7028:
7022:
7020:
7014:
7013:
7011:
7010:
7005:
7000:
6999:
6998:
6993:
6982:
6980:
6974:
6973:
6959:
6957:
6956:
6949:
6942:
6934:
6925:
6924:
6921:
6920:
6918:
6917:
6912:
6907:
6901:
6899:
6892:
6891:
6889:
6888:
6879:
6877:
6870:
6869:
6867:
6866:
6857:
6855:
6845:
6844:
6842:
6841:
6832:
6830:
6817:
6812:
6806:protein kinase
6801:
6800:
6797:
6796:
6794:
6793:
6787:
6785:
6781:
6780:
6778:
6777:
6772:
6767:
6762:
6756:
6754:
6747:
6740:
6739:
6736:
6735:
6733:
6732:
6727:
6716:
6714:
6710:
6709:
6707:
6706:
6700:
6698:
6692:
6691:
6689:
6688:
6683:
6677:
6675:
6669:
6668:
6666:
6665:
6660:
6654:
6652:
6645:Phosphorolytic
6641:
6640:
6637:
6636:
6634:
6633:
6628:
6623:
6618:
6613:
6612:
6611:
6606:
6601:
6591:
6590:
6589:
6579:
6574:
6569:
6564:
6559:
6554:
6548:
6546:
6544:RNA polymerase
6540:
6539:
6537:
6536:
6535:
6534:
6524:
6520:
6519:
6518:
6517:
6512:
6507:
6496:
6495:
6494:
6489:
6484:
6479:
6468:
6462:
6461:
6460:
6453:
6448:
6443:
6438:
6427:
6426:
6425:
6418:
6413:
6408:
6403:
6392:
6388:
6386:
6384:DNA polymerase
6377:
6368:
6362:
6348:
6347:
6345:
6344:
6339:
6333:
6331:
6326:
6322:
6308:
6307:
6304:
6303:
6301:
6300:
6295:
6290:
6285:
6280:
6275:
6269:
6267:
6262:
6253:
6252:
6250:
6249:
6243:
6241:
6230:
6229:
6227:
6226:
6221:
6215:
6213:
6202:
6201:
6199:
6198:
6193:
6188:
6187:
6186:
6181:
6171:
6169:Diacylglycerol
6166:
6161:
6156:
6151:
6146:
6141:
6136:
6131:
6130:
6129:
6119:
6114:
6109:
6108:
6107:
6102:
6097:
6092:
6087:
6080:Phosphofructo-
6077:
6072:
6071:
6070:
6060:
6055:
6049:
6047:
6033:
6028:
6012:
6011:
5997:
5995:
5994:
5987:
5980:
5972:
5963:
5962:
5960:
5959:
5948:
5945:
5944:
5942:
5941:
5936:
5931:
5926:
5921:
5916:
5915:
5914:
5909:
5904:
5899:
5894:
5889:
5884:
5879:
5864:
5863:
5858:
5848:
5847:
5842:
5837:
5832:
5827:
5822:
5816:
5814:
5810:
5809:
5807:
5806:
5801:
5795:
5793:
5789:
5788:
5786:
5785:
5784:
5783:
5778:
5768:
5763:
5758:
5757:
5756:
5746:
5741:
5740:
5739:
5734:
5723:
5721:
5720:Other pathways
5717:
5716:
5714:
5713:
5708:
5703:
5698:
5693:
5692:
5691:
5681:
5676:
5670:
5668:
5662:
5661:
5659:
5658:
5657:
5656:
5651:
5641:
5640:
5639:
5634:
5629:
5624:
5619:
5614:
5609:
5604:
5599:
5594:
5589:
5584:
5570:
5569:
5568:
5563:
5558:
5543:
5541:
5535:
5534:
5529:
5527:
5526:
5519:
5512:
5504:
5495:
5494:
5492:
5491:
5490:
5489:
5484:
5479:
5464:
5462:
5456:
5455:
5452:
5451:
5449:
5448:
5443:
5436:
5434:
5430:
5429:
5427:
5426:
5420:
5419:
5418:
5417:
5406:
5405:
5404:
5403:
5398:
5393:
5388:
5378:
5377:
5376:
5371:
5366:
5361:
5351:
5350:
5349:
5344:
5339:
5334:
5324:
5317:
5316:
5315:
5314:
5304:
5299:
5298:
5297:
5287:
5286:
5285:
5274:
5272:
5260:
5259:
5257:
5256:
5255:
5254:
5239:
5238:
5237:
5236:
5226:
5221:
5216:
5211:
5210:
5209:
5204:
5199:
5194:
5189:
5184:
5179:
5174:
5169:
5164:
5159:
5154:
5143:
5141:
5128:
5122:
5121:
5118:
5117:
5115:
5114:
5109:
5104:
5103:
5102:
5087:
5086:
5072:
5070:
5066:
5065:
5063:
5062:
5057:
5047:
5046:
5036:
5035:
5034:
5033:
5028:
5017:
5016:
5015:
5014:
5009:
5004:
4993:
4992:
4986:
4985:
4979:
4978:
4977:
4976:
4971:
4966:
4961:
4956:
4951:
4940:
4939:
4933:
4932:
4926:
4925:
4924:
4923:
4918:
4913:
4908:
4903:
4898:
4887:
4886:
4880:
4878:
4873:preparation in
4866:
4865:
4863:
4862:
4861:
4860:
4849:
4848:
4847:
4846:
4841:
4836:
4825:
4824:
4818:
4817:
4811:
4809:
4796:
4790:
4789:
4775:
4773:
4772:
4765:
4758:
4750:
4744:
4743:
4733:
4721:
4720:External links
4718:
4716:
4715:
4700:
4682:
4657:
4631:
4572:
4531:
4502:
4473:(1): 135–152.
4453:
4394:
4373:(2): 253–263.
4367:Molecular Cell
4353:
4304:
4275:(6): 775–787.
4255:
4248:
4230:
4209:(6): 751–771.
4186:
4130:
4068:
4019:
3962:
3915:
3883:|journal=
3859:
3800:
3757:
3730:(1): 100–103.
3711:
3659:
3638:(4): 655–666.
3618:
3575:
3525:
3465:
3419:
3365:
3338:Molecular Cell
3321:
3306:
3277:
3248:(5): 789–800.
3199:
3170:(3): 931–941.
3150:
3127:
3071:
3027:
3011:
2990:(6): 837–845.
2965:
2913:
2894:(1–2): 11–31.
2878:
2829:
2790:(10): e77364.
2770:
2741:(3): 313–324.
2714:
2646:
2627:(1–2): 79–83.
2611:
2570:
2511:
2462:
2453:
2404:
2363:
2314:
2265:
2213:
2167:
2129:
2108:(2): 441–449.
2085:
2073:
2044:
2032:
1968:
1908:
1860:
1836:
1774:
1715:
1671:
1642:(1): 118–137.
1617:
1565:
1563:
1560:
1559:
1558:
1553:
1464:
1407:
1360:
1357:
1351:
1348:
1327:
1326:
1306:
1303:
1301:
1298:
1232:
1229:
1136:Bloom syndrome
1128:RecQ helicases
1116:
1113:
1069:
1066:
1058:ATR-X syndrome
1038:
1035:
1033:
1030:
1022:
1021:
1011:
1001:
995:
989:
983:
947:
944:
916:, involved in
898:
895:
894:
893:
883:
877:
871:
865:
859:
853:
847:
841:
835:
829:
823:
817:
797:
794:
771:
744:
714:
687:
666:
657:
653:
650:
625:
622:
619:
616:
613:
609:
586:
583:
579:
549:
519:
498:
489:
485:
482:
469:
466:
461:
460:
442:
431:
413:
402:
384:
380:
370:
358:
344:
343:
332:
323:
319:
310:
306:
297:
293:
290:
287:
284:
281:
258:
246:
243:
232:
231:
225:
224:
223:
176:directionality
148:hydrogen bonds
128:
125:
61:motor proteins
26:
24:
14:
13:
10:
9:
6:
4:
3:
2:
8167:
8156:
8153:
8151:
8148:
8146:
8143:
8142:
8140:
8130:
8125:
8120:
8116:
8102:
8098:
8097:
8092:
8089:
8085:
8084:
8079:
8076:
8072:
8071:
8066:
8063:
8059:
8058:
8053:
8050:
8046:
8045:
8040:
8037:
8033:
8032:
8027:
8024:
8020:
8019:
8014:
8013:
8011:
8007:
8001:
7998:
7996:
7993:
7991:
7988:
7986:
7983:
7981:
7978:
7977:
7975:
7971:
7965:
7962:
7960:
7959:Enzyme family
7957:
7955:
7952:
7950:
7947:
7946:
7944:
7940:
7934:
7931:
7929:
7926:
7924:
7923:Cooperativity
7921:
7919:
7916:
7915:
7913:
7909:
7903:
7900:
7898:
7895:
7893:
7890:
7888:
7885:
7883:
7882:Oxyanion hole
7880:
7878:
7875:
7873:
7870:
7868:
7865:
7864:
7862:
7858:
7854:
7847:
7842:
7840:
7835:
7833:
7828:
7827:
7824:
7808:
7805:
7801:
7798:
7796:
7792:
7789:
7787:
7784:
7782:
7779:
7777:
7774:
7773:
7772:
7769:
7768:
7766:
7764:
7759:
7753:
7750:
7746:
7743:
7741:
7738:
7736:
7733:
7732:
7731:
7728:
7727:
7725:
7723:
7718:
7712:
7709:
7707:
7704:
7702:
7699:
7697:
7694:
7690:
7687:
7685:
7682:
7680:
7677:
7675:
7672:
7671:
7670:
7667:
7663:
7660:
7658:
7655:
7654:
7653:
7650:
7646:
7643:
7641:
7638:
7636:
7633:
7632:
7631:
7627:
7626:
7621:
7618:
7616:
7613:
7612:
7611:
7608:
7604:
7601:
7599:
7596:
7594:
7591:
7590:
7589:
7586:
7582:
7579:
7577:
7574:
7572:
7569:
7568:
7567:
7564:
7562:
7559:
7555:
7552:
7550:
7547:
7546:
7545:
7542:
7538:
7535:
7533:
7530:
7528:
7525:
7523:
7520:
7519:
7518:
7515:
7511:
7508:
7506:
7503:
7502:
7501:
7498:
7494:
7491:
7489:
7486:
7484:
7481:
7480:
7479:
7475:
7472:
7471:
7469:
7467:
7463:
7458:
7450:
7447:
7445:
7442:
7441:
7440:
7434:
7430:
7427:
7425:
7422:
7421:
7420:
7414:
7408:
7405:
7404:
7403:
7400:
7396:
7393:
7391:
7388:
7387:
7386:
7383:
7381:
7378:
7376:
7373:
7371:
7368:
7367:
7366:
7360:
7356:
7350:
7349:
7348:
7342:
7341:
7339:
7337:
7332:
7329:
7327:
7323:
7319:
7309:
7306:
7304:
7301:
7299:
7296:
7294:
7291:
7290:
7288:
7284:
7274:
7271:
7269:
7266:
7264:
7261:
7259:
7256:
7254:
7251:
7249:
7246:
7245:
7243:
7241:
7240:P-type ATPase
7236:
7230:
7227:
7226:
7224:
7221:
7217:
7211:
7208:
7206:
7203:
7201:
7198:
7196:
7193:
7191:
7188:
7186:
7183:
7181:
7178:
7176:
7173:
7172:
7170:
7167:
7163:
7155:
7152:
7150:
7147:
7146:
7145:
7142:
7138:
7135:
7133:
7130:
7128:
7125:
7123:
7120:
7119:
7118:
7115:
7111:
7108:
7106:
7103:
7101:
7098:
7097:
7096:
7093:
7092:
7090:
7087:
7083:
7077:
7074:
7072:
7069:
7068:
7066:
7062:
7059:
7055:
7052:
7050:
7046:
7042:
7038:
7032:
7029:
7027:
7024:
7023:
7021:
7019:
7015:
7009:
7006:
7004:
7001:
6997:
6994:
6992:
6989:
6988:
6987:
6984:
6983:
6981:
6979:
6975:
6970:
6966:
6962:
6955:
6950:
6948:
6943:
6941:
6936:
6935:
6932:
6916:
6913:
6911:
6908:
6906:
6903:
6902:
6900:
6897:
6893:
6887:
6886:
6881:
6880:
6878:
6875:
6871:
6865:
6864:
6859:
6858:
6856:
6854:
6850:
6846:
6840:
6839:
6834:
6833:
6831:
6829:
6825:
6821:
6818:
6815:
6807:
6802:
6792:
6789:
6788:
6786:
6782:
6776:
6773:
6771:
6768:
6766:
6763:
6761:
6758:
6757:
6755:
6751:
6748:
6745:
6741:
6731:
6728:
6725:
6721:
6718:
6717:
6715:
6711:
6705:
6702:
6701:
6699:
6697:
6693:
6687:
6684:
6682:
6679:
6678:
6676:
6674:
6670:
6664:
6661:
6659:
6656:
6655:
6653:
6651:
6646:
6642:
6632:
6629:
6627:
6624:
6622:
6619:
6617:
6614:
6610:
6607:
6605:
6602:
6600:
6597:
6596:
6595:
6592:
6588:
6585:
6584:
6583:
6580:
6578:
6575:
6573:
6570:
6568:
6565:
6563:
6560:
6558:
6555:
6553:
6550:
6549:
6547:
6545:
6541:
6533:
6530:
6529:
6528:
6525:
6522:
6521:
6516:
6513:
6511:
6508:
6506:
6503:
6502:
6500:
6497:
6493:
6490:
6488:
6485:
6483:
6480:
6478:
6475:
6474:
6472:
6469:
6466:
6463:
6459:
6458:
6454:
6452:
6449:
6447:
6444:
6442:
6439:
6437:
6434:
6433:
6431:
6428:
6424:
6423:
6419:
6417:
6414:
6412:
6409:
6407:
6404:
6402:
6399:
6398:
6396:
6393:
6390:
6389:
6387:
6385:
6381:
6378:
6376:
6372:
6369:
6366:
6357:
6353:
6349:
6343:
6340:
6338:
6335:
6334:
6332:
6329:
6317:
6313:
6309:
6299:
6296:
6294:
6291:
6289:
6286:
6284:
6281:
6279:
6276:
6274:
6271:
6270:
6268:
6265:
6258:
6254:
6248:
6245:
6244:
6242:
6239:
6235:
6231:
6225:
6222:
6220:
6217:
6216:
6214:
6211:
6207:
6203:
6197:
6194:
6192:
6189:
6185:
6184:Class II PI 3
6182:
6180:
6177:
6176:
6175:
6172:
6170:
6167:
6165:
6162:
6160:
6159:Deoxycytidine
6157:
6155:
6152:
6150:
6147:
6145:
6142:
6140:
6137:
6135:
6132:
6128:
6127:ADP-thymidine
6125:
6124:
6123:
6120:
6118:
6115:
6113:
6110:
6106:
6103:
6101:
6098:
6096:
6093:
6091:
6088:
6086:
6083:
6082:
6081:
6078:
6076:
6073:
6069:
6066:
6065:
6064:
6061:
6059:
6056:
6054:
6051:
6050:
6048:
6045:
6041:
6037:
6034:
6031:
6023:
6019:
6013:
6008:
6004:
6000:
5993:
5988:
5986:
5981:
5979:
5974:
5973:
5970:
5958:
5950:
5949:
5946:
5940:
5937:
5935:
5932:
5930:
5927:
5925:
5922:
5920:
5917:
5913:
5910:
5908:
5905:
5903:
5900:
5898:
5895:
5893:
5890:
5888:
5885:
5883:
5880:
5878:
5875:
5874:
5873:
5869:
5868:FANC proteins
5866:
5865:
5862:
5859:
5857:
5853:
5850:
5849:
5846:
5843:
5841:
5838:
5836:
5833:
5831:
5828:
5826:
5823:
5821:
5818:
5817:
5815:
5811:
5805:
5802:
5800:
5797:
5796:
5794:
5790:
5782:
5779:
5777:
5774:
5773:
5772:
5769:
5767:
5764:
5762:
5759:
5755:
5752:
5751:
5750:
5747:
5745:
5742:
5738:
5735:
5733:
5730:
5729:
5728:
5725:
5724:
5722:
5718:
5712:
5709:
5707:
5704:
5702:
5699:
5697:
5694:
5690:
5689:RecQ helicase
5687:
5686:
5685:
5682:
5680:
5677:
5675:
5672:
5671:
5669:
5667:
5663:
5655:
5652:
5650:
5647:
5646:
5645:
5642:
5638:
5635:
5633:
5630:
5628:
5625:
5623:
5620:
5618:
5615:
5613:
5610:
5608:
5605:
5603:
5600:
5598:
5595:
5593:
5590:
5588:
5585:
5583:
5580:
5579:
5578:
5574:
5571:
5567:
5564:
5562:
5559:
5557:
5554:
5553:
5552:
5548:
5545:
5544:
5542:
5540:
5536:
5532:
5525:
5520:
5518:
5513:
5511:
5506:
5505:
5502:
5488:
5485:
5483:
5480:
5478:
5475:
5474:
5473:
5469:
5466:
5465:
5463:
5461:
5457:
5447:
5444:
5442:
5438:
5437:
5435:
5431:
5425:
5422:
5421:
5416:
5413:
5412:
5411:
5408:
5407:
5402:
5399:
5397:
5394:
5392:
5389:
5387:
5384:
5383:
5382:
5379:
5375:
5372:
5370:
5367:
5365:
5362:
5360:
5357:
5356:
5355:
5352:
5348:
5345:
5343:
5340:
5338:
5335:
5333:
5330:
5329:
5328:
5325:
5322:
5319:
5318:
5313:
5310:
5309:
5308:
5305:
5303:
5302:Topoisomerase
5300:
5296:
5293:
5292:
5291:
5288:
5284:
5281:
5280:
5279:
5276:
5275:
5273:
5270:
5261:
5253:
5250:
5249:
5248:
5244:
5241:
5240:
5235:
5232:
5231:
5230:
5229:Topoisomerase
5227:
5225:
5222:
5220:
5217:
5215:
5212:
5208:
5205:
5203:
5200:
5198:
5195:
5193:
5190:
5188:
5185:
5183:
5180:
5178:
5175:
5173:
5170:
5168:
5165:
5163:
5160:
5158:
5155:
5153:
5150:
5149:
5148:
5145:
5144:
5142:
5139:
5132:
5129:
5127:
5123:
5113:
5110:
5108:
5105:
5101:
5097:
5094:
5093:
5092:
5089:
5088:
5085:
5081:
5077:
5074:
5073:
5071:
5067:
5061:
5058:
5056:
5052:
5049:
5048:
5045:
5041:
5038:
5037:
5032:
5029:
5027:
5024:
5023:
5022:
5019:
5018:
5013:
5010:
5008:
5005:
5003:
5000:
4999:
4998:
4995:
4994:
4991:
4988:
4987:
4984:
4981:
4980:
4975:
4972:
4970:
4967:
4965:
4962:
4960:
4957:
4955:
4952:
4950:
4947:
4946:
4945:
4942:
4941:
4938:
4935:
4934:
4931:
4928:
4927:
4922:
4919:
4917:
4914:
4912:
4909:
4907:
4904:
4902:
4899:
4897:
4894:
4893:
4892:
4889:
4888:
4885:
4882:
4881:
4879:
4876:
4867:
4859:
4856:
4855:
4854:
4851:
4850:
4845:
4842:
4840:
4837:
4835:
4832:
4831:
4830:
4827:
4826:
4823:
4820:
4819:
4816:
4813:
4812:
4810:
4807:
4800:
4797:
4795:
4791:
4786:
4782:
4778:
4771:
4766:
4764:
4759:
4757:
4752:
4751:
4748:
4741:
4737:
4736:RNA+Helicases
4734:
4731:
4727:
4726:DNA+Helicases
4724:
4723:
4719:
4711:
4707:
4703:
4697:
4693:
4686:
4683:
4678:
4674:
4669:
4664:
4660:
4658:9780128092675
4654:
4650:
4646:
4642:
4635:
4632:
4627:
4623:
4618:
4613:
4608:
4603:
4599:
4595:
4591:
4587:
4583:
4576:
4573:
4568:
4564:
4559:
4554:
4550:
4546:
4542:
4535:
4532:
4521:on 2014-12-18
4520:
4516:
4512:
4506:
4503:
4498:
4494:
4489:
4484:
4480:
4476:
4472:
4468:
4464:
4457:
4454:
4449:
4445:
4440:
4435:
4430:
4425:
4421:
4417:
4413:
4409:
4405:
4398:
4395:
4390:
4386:
4381:
4376:
4372:
4368:
4364:
4357:
4354:
4349:
4345:
4340:
4335:
4331:
4327:
4323:
4319:
4315:
4308:
4305:
4300:
4296:
4291:
4286:
4282:
4278:
4274:
4270:
4266:
4259:
4256:
4251:
4245:
4241:
4234:
4231:
4226:
4222:
4217:
4212:
4208:
4204:
4200:
4193:
4191:
4187:
4182:
4178:
4173:
4168:
4164:
4160:
4156:
4152:
4148:
4141:
4139:
4137:
4135:
4131:
4126:
4122:
4117:
4112:
4107:
4102:
4098:
4094:
4090:
4086:
4082:
4075:
4073:
4069:
4064:
4060:
4055:
4050:
4046:
4042:
4038:
4034:
4030:
4023:
4020:
4015:
4011:
4006:
4001:
3997:
3993:
3989:
3985:
3981:
3977:
3973:
3966:
3963:
3958:
3954:
3950:
3946:
3942:
3938:
3934:
3930:
3926:
3919:
3916:
3911:
3907:
3900:
3888:
3875:
3863:
3860:
3855:
3851:
3846:
3841:
3837:
3833:
3828:
3823:
3819:
3815:
3811:
3804:
3801:
3796:
3792:
3788:
3784:
3780:
3776:
3772:
3768:
3761:
3758:
3753:
3749:
3745:
3741:
3737:
3733:
3729:
3725:
3718:
3716:
3712:
3707:
3703:
3698:
3693:
3689:
3685:
3681:
3677:
3673:
3666:
3664:
3660:
3655:
3651:
3646:
3641:
3637:
3633:
3629:
3622:
3619:
3614:
3610:
3606:
3602:
3598:
3594:
3590:
3586:
3579:
3576:
3571:
3567:
3562:
3557:
3553:
3549:
3545:
3538:
3536:
3534:
3532:
3530:
3526:
3521:
3517:
3513:
3509:
3504:
3499:
3495:
3491:
3487:
3483:
3479:
3472:
3470:
3466:
3461:
3457:
3453:
3449:
3445:
3441:
3437:
3433:
3426:
3424:
3420:
3415:
3411:
3407:
3403:
3399:
3395:
3391:
3387:
3383:
3379:
3372:
3370:
3366:
3361:
3357:
3352:
3347:
3343:
3339:
3335:
3328:
3326:
3322:
3317:
3313:
3309:
3307:9780121828134
3303:
3299:
3295:
3291:
3284:
3282:
3278:
3273:
3269:
3264:
3259:
3255:
3251:
3247:
3243:
3239:
3232:
3230:
3228:
3226:
3224:
3222:
3220:
3218:
3216:
3214:
3212:
3210:
3208:
3206:
3204:
3200:
3195:
3191:
3186:
3181:
3177:
3173:
3169:
3165:
3161:
3154:
3151:
3146:
3142:
3138:
3131:
3128:
3123:
3119:
3114:
3109:
3104:
3099:
3095:
3091:
3087:
3080:
3078:
3076:
3072:
3067:
3063:
3058:
3053:
3049:
3045:
3041:
3034:
3032:
3028:
3024:
3018:
3016:
3012:
3007:
3003:
2998:
2993:
2989:
2985:
2981:
2974:
2972:
2970:
2966:
2961:
2957:
2953:
2949:
2945:
2941:
2937:
2933:
2926:
2924:
2922:
2920:
2918:
2914:
2909:
2905:
2901:
2897:
2893:
2889:
2882:
2879:
2874:
2870:
2865:
2860:
2856:
2852:
2848:
2844:
2840:
2833:
2830:
2825:
2821:
2816:
2811:
2806:
2801:
2797:
2793:
2789:
2785:
2781:
2774:
2771:
2766:
2762:
2757:
2752:
2748:
2744:
2740:
2736:
2732:
2725:
2723:
2721:
2719:
2715:
2710:
2706:
2702:
2698:
2694:
2690:
2683:
2681:
2679:
2677:
2675:
2673:
2671:
2669:
2667:
2665:
2663:
2661:
2659:
2657:
2655:
2653:
2651:
2647:
2642:
2638:
2634:
2630:
2626:
2622:
2615:
2612:
2607:
2603:
2598:
2593:
2589:
2585:
2581:
2574:
2571:
2566:
2562:
2557:
2552:
2547:
2542:
2538:
2534:
2530:
2526:
2522:
2515:
2512:
2507:
2503:
2498:
2493:
2489:
2485:
2481:
2477:
2473:
2466:
2463:
2457:
2454:
2449:
2445:
2440:
2435:
2431:
2427:
2423:
2419:
2415:
2408:
2405:
2400:
2396:
2391:
2386:
2382:
2378:
2374:
2367:
2364:
2359:
2355:
2350:
2345:
2341:
2337:
2333:
2329:
2325:
2318:
2315:
2310:
2306:
2301:
2296:
2292:
2288:
2284:
2280:
2276:
2269:
2266:
2261:
2257:
2252:
2247:
2243:
2239:
2235:
2231:
2227:
2220:
2218:
2214:
2209:
2205:
2200:
2195:
2191:
2187:
2183:
2176:
2174:
2172:
2168:
2163:
2159:
2155:
2151:
2147:
2143:
2136:
2134:
2130:
2125:
2121:
2116:
2111:
2107:
2103:
2099:
2092:
2090:
2086:
2082:
2077:
2074:
2063:on 2021-01-26
2062:
2058:
2054:
2048:
2045:
2041:
2036:
2033:
2028:
2024:
2019:
2014:
2010:
2006:
2003:: 3765–3778.
2002:
1998:
1994:
1992:
1983:
1981:
1979:
1977:
1975:
1973:
1969:
1964:
1960:
1955:
1950:
1946:
1942:
1938:
1934:
1930:
1923:
1921:
1919:
1917:
1915:
1913:
1909:
1904:
1900:
1896:
1892:
1889:(2): 029906.
1888:
1884:
1880:
1873:
1871:
1869:
1867:
1865:
1861:
1849:
1843:
1841:
1837:
1832:
1828:
1823:
1818:
1814:
1810:
1806:
1802:
1798:
1791:
1789:
1787:
1785:
1783:
1781:
1779:
1775:
1770:
1766:
1761:
1756:
1751:
1746:
1742:
1738:
1734:
1730:
1726:
1719:
1716:
1711:
1707:
1702:
1697:
1693:
1689:
1685:
1678:
1676:
1672:
1667:
1663:
1658:
1653:
1649:
1645:
1641:
1637:
1633:
1626:
1624:
1622:
1618:
1613:
1609:
1604:
1599:
1594:
1589:
1585:
1581:
1577:
1574:Wu Y (2012).
1570:
1567:
1561:
1557:
1554:
1552:
1548:
1544:
1540:
1536:
1532:
1528:
1524:
1520:
1516:
1512:
1508:
1504:
1500:
1496:
1492:
1488:
1484:
1480:
1476:
1472:
1468:
1465:
1463:
1459:
1455:
1451:
1447:
1443:
1439:
1435:
1431:
1427:
1423:
1419:
1415:
1411:
1408:
1406:
1402:
1398:
1394:
1390:
1386:
1382:
1378:
1374:
1370:
1366:
1363:
1362:
1358:
1356:
1349:
1347:
1345:
1340:
1337:
1333:
1324:
1320:
1319:radiolabeling
1316:
1315:
1314:
1312:
1304:
1299:
1297:
1294:
1292:
1286:
1282:
1280:
1276:
1272:
1268:
1264:
1259:
1255:
1245:
1237:
1231:RNA helicases
1230:
1228:
1226:
1222:
1221:
1217:In the plant
1215:
1213:
1209:
1205:
1201:
1197:
1196:
1191:
1187:
1183:
1179:
1175:
1171:
1166:
1164:
1160:
1155:
1151:
1147:
1145:
1141:
1137:
1133:
1129:
1123:RecQ helicase
1121:
1114:
1112:
1108:
1104:
1100:
1097:
1093:
1088:
1086:
1082:
1078:
1074:
1067:
1065:
1061:
1059:
1055:
1051:
1046:
1045:
1036:
1031:
1029:
1027:
1019:
1015:
1012:
1009:
1005:
1002:
999:
996:
993:
990:
987:
984:
981:
980:gram-positive
977:
976:gram-negative
973:
969:
966:
965:
964:
962:
958:
954:
946:Superfamilies
945:
943:
941:
936:
934:
930:
927:
923:
920:binding, ATP
919:
915:
911:
907:
904:
896:
891:
887:
884:
881:
878:
875:
872:
869:
866:
863:
860:
857:
854:
851:
848:
845:
842:
839:
836:
833:
830:
827:
824:
821:
818:
815:
811:
808:
807:
806:
803:
795:
793:
789:
769:
742:
732:
712:
704:is closer to
685:
664:
655:
651:
648:
639:
623:
620:
617:
614:
611:
607:
584:
581:
577:
568:
564:
547:
539:
517:
496:
487:
483:
480:
467:
465:
440:
432:
411:
403:
382:
371:
356:
349:
348:
347:
321:
317:
308:
304:
295:
285:
282:
279:
272:
271:
270:
256:
244:
236:
229:
222:
220:
219:
214:
213:
208:
204:
200:
196:
192:
188:
183:
181:
177:
173:
169:
165:
161:
157:
153:
149:
145:
141:
137:
134:
126:
124:
121:
117:
113:
112:recombination
109:
105:
104:transcription
101:
97:
92:
90:
87:
83:
82:
78:
73:
70:
66:
65:directionally
62:
58:
54:
50:
46:
39:
38:
34:Structure of
32:
19:
8096:Translocases
8093:
8080:
8067:
8054:
8041:
8031:Transferases
8028:
8015:
7872:Binding site
7609:
7543:
7499:
7477:
7462:Small GTPase
7076:Wilson/ATP7B
7071:Menkes/ATP7A
6882:
6860:
6835:
6456:
6421:
6179:Class I PI 3
6144:Pantothenate
6015:2.7.1-2.7.4:
5999:Transferases
5871:
5852:DNA helicase
5851:
5835:8-Oxoguanine
5804:SOS response
5684:RecF pathway
5637:Excinuclease
5441:Processivity
5267:synthesis in
5039:
4828:
4691:
4685:
4640:
4634:
4589:
4585:
4575:
4548:
4544:
4534:
4523:. Retrieved
4519:the original
4514:
4511:"Index of /"
4505:
4470:
4466:
4456:
4411:
4407:
4397:
4370:
4366:
4356:
4324:(1): 19–29.
4321:
4317:
4307:
4272:
4268:
4258:
4239:
4233:
4206:
4202:
4154:
4150:
4088:
4084:
4036:
4032:
4022:
3979:
3975:
3965:
3932:
3928:
3918:
3895:|title=
3874:cite journal
3862:
3817:
3813:
3803:
3779:10.1038/8788
3773:(1): 82–84.
3770:
3766:
3760:
3727:
3723:
3679:
3675:
3635:
3631:
3621:
3588:
3584:
3578:
3551:
3547:
3485:
3481:
3435:
3431:
3381:
3377:
3344:(1): 87–95.
3341:
3337:
3289:
3245:
3241:
3167:
3163:
3153:
3136:
3130:
3093:
3089:
3047:
3043:
2987:
2983:
2938:(1): 46–57.
2935:
2931:
2891:
2887:
2881:
2846:
2842:
2832:
2787:
2783:
2773:
2738:
2734:
2692:
2688:
2624:
2620:
2614:
2590:(1): 54–63.
2587:
2583:
2573:
2528:
2524:
2514:
2479:
2475:
2465:
2456:
2421:
2417:
2407:
2380:
2376:
2366:
2331:
2327:
2317:
2282:
2278:
2268:
2233:
2229:
2189:
2185:
2145:
2142:Biochemistry
2141:
2105:
2101:
2076:
2065:. Retrieved
2061:the original
2056:
2047:
2035:
2000:
1996:
1990:
1936:
1932:
1886:
1882:
1852:. Retrieved
1850:. 2007-07-03
1804:
1800:
1732:
1728:
1718:
1691:
1687:
1639:
1635:
1583:
1579:
1569:
1365:Chromodomain
1353:
1341:
1328:
1310:
1308:
1295:
1287:
1283:
1251:
1218:
1216:
1193:
1167:
1163:poikiloderma
1156:
1152:
1148:
1126:
1109:
1105:
1101:
1089:
1071:
1062:
1053:
1042:
1040:
1026:Walker motif
1023:
1013:
1003:
997:
991:
985:
967:
949:
937:
926:nucleic acid
900:
889:
885:
879:
873:
867:
861:
855:
849:
843:
837:
831:
825:
819:
813:
809:
801:
799:
790:
733:
640:
471:
462:
345:
248:
216:
210:
184:
180:processivity
172:nucleic acid
164:RNA splicing
136:double helix
130:
96:human genome
93:
75:
69:nucleic acid
44:
43:
35:
18:RNA helicase
7867:Active site
7786:Mitofusin-1
7761:3.6.5.5-6:
7730:Prokaryotic
6730:Transposase
6720:Recombinase
6365:-nucleoside
6191:Sphingosine
5460:Termination
5134:Prokaryotic
5126:Replication
4802:Prokaryotic
4781:prokaryotic
4779:(comparing
4269:RNA Biology
4203:RNA Biology
3137:GeneReviews
1344:PerkinElmer
1258:translation
1174:DNA damages
1142:(RTS), and
168:RNA editing
108:translation
8139:Categories
8070:Isomerases
8044:Hydrolases
7911:Regulation
7752:Eukaryotic
7385:Transducin
7222:(3.6.3.10)
6961:Hydrolases
6532:Telomerase
6375:Polymerase
6149:Mevalonate
6112:Riboflavin
6003:phosphorus
5792:Regulation
5771:Photolyase
5531:DNA repair
5472:Telomerase
5446:DNA ligase
5439:Movement:
5263:Eukaryotic
5234:DNA gyrase
5219:DNA ligase
5138:elongation
4869:Eukaryotic
4806:initiation
4794:Initiation
4785:eukaryotic
4525:2012-12-07
3820:(2): 205.
2083:(Advanced)
2067:2024-01-03
1854:2007-07-05
1586:: 140601.
1562:References
933:amino acid
922:hydrolysis
903:amino acid
116:DNA repair
89:hydrolysis
63:that move
8155:Helicases
7949:EC number
7720:3.6.5.3:
7460:3.6.5.2:
7402:Gustducin
7334:3.6.5.1:
7168:(3.6.3.9)
7088:(3.6.3.8)
6991:Inorganic
6724:Integrase
6648:3' to 5'
6293:Guanylate
6288:Uridylate
6278:Adenylate
6122:Thymidine
6117:Shikimate
5612:XPG/ERCC5
5597:XPD/ERCC2
5410:DNA clamp
5224:DNA clamp
5214:Replisome
4710:246537432
3949:1090-2104
3836:2073-4425
3795:195211275
2695:: 23–50.
1190:crossover
1178:chromatid
1079:(CS) and
929:substrate
379:Δ
318:−
305:−
292:Δ
53:organisms
45:Helicases
8145:EC 3.6.4
7973:Kinetics
7897:Cofactor
7860:Activity
6996:Thiamine
6658:RNase PH
6266:acceptor
6247:Creatine
6240:acceptor
6212:acceptor
6154:Pyruvate
6139:Glycerol
6100:Platelet
6075:Galacto-
6046:acceptor
5957:Category
5607:XPF/DDB1
5602:XPE/DDB1
5468:Telomere
5084:Replicon
5040:Helicase
5031:RNASEH2A
4875:G1 phase
4829:Helicase
4677:27793277
4626:22665805
4497:21297876
4448:19088201
4389:17964264
4348:20813532
4299:21173576
4225:22699555
4181:21112871
4125:25825745
4063:25414342
4014:22723423
3854:32085395
3787:10319867
3752:20587915
3706:18682526
3605:18430459
3570:15023996
3520:29287970
3512:17571213
3503:11136437
3360:10024882
3316:16793373
3272:18510924
3194:19933257
3145:20301622
3122:16722615
2952:15630421
2908:15037234
2873:11689653
2824:24143224
2784:PLOS ONE
2765:20456941
2709:17506634
2641:12387853
2260:15128294
2027:34285777
1991:In vitro
1963:20423906
1831:17604719
1769:18077411
1710:16670085
1666:21509200
1612:22888405
1543:SMARCAL1
1410:DEAD box
1359:See also
1311:in vitro
1254:ribosome
567:cytosine
509:, where
218:in vitro
203:monomers
199:hexamers
150:between
127:Function
67:along a
8129:Biology
8083:Ligases
7853:Enzymes
7807:Tubulin
7776:Dynamin
7628:other:
7308:Katanin
7298:Kinesin
7273:ATP13A3
7268:ATP13A2
7003:Apyrase
6609:PrimPol
6594:Primase
6068:Hepatic
6063:Fructo-
5799:SOS box
5551:AP site
5381:epsilon
5269:S phase
5096:Lagging
5051:Primase
5026:RNASEH1
5021:RNase H
4853:Primase
4668:5854184
4617:3382518
4594:Bibcode
4567:6315716
4488:3032546
4439:2629341
4416:Bibcode
4339:3017212
4290:3073335
4172:3013637
4116:4403193
4093:Bibcode
4054:4267644
4005:3399777
3984:Bibcode
3976:Science
3845:7074392
3744:9288107
3697:2532730
3654:7585968
3613:6804631
3460:8465201
3440:Bibcode
3432:Science
3414:4334960
3406:8413672
3386:Bibcode
3263:3055247
3185:2817471
3113:1464382
3066:8968741
3006:7697714
2815:3797037
2792:Bibcode
2756:2916977
2606:8665952
2565:1326759
2533:Bibcode
2506:1702201
2448:2546125
2399:3017945
2358:3019672
2349:1167061
2309:3162158
2251:7164108
2208:6288720
2018:8267548
1954:2938219
1891:Bibcode
1822:2699903
1760:2148377
1737:Bibcode
1657:3073292
1603:3409536
1539:SMARCA4
1170:meiosis
1168:During
814:E. coli
802:E. coli
563:guanine
536:is the
212:in vivo
49:enzymes
37:E. coli
8115:Portal
8057:Lyases
7684:ARL13B
7544:RhoBTB
7438:α12/13
7326:GTPase
7303:Myosin
7293:Dynein
7263:ATP12A
7258:ATP11B
7253:ATP10A
7248:ATP8B1
7238:Other
7210:ATP1B4
7205:ATP1B3
7200:ATP1B2
7195:ATP1B1
7190:ATP1A4
7185:ATP1A3
7180:ATP1A2
7175:ATP1A1
7166:Na+/K+
7154:ATP2C2
7149:ATP2C1
7137:ATP2B4
7132:ATP2B3
7127:ATP2B2
7122:ATP2B1
7110:ATP2A3
7105:ATP2A2
7100:ATP2A1
7049:ATPase
6896:2.7.13
6874:2.7.12
6849:2.7.11
6824:2.7.10
6663:PNPase
6631:PNPase
6587:POLRMT
6582:ssRNAP
6095:Muscle
6058:Gluco-
6022:kinase
5924:FANCD2
5919:FANCD1
5679:RecBCD
5632:RAD23B
5627:RAD23A
5112:Primer
4742:(MeSH)
4732:(MeSH)
4708:
4698:
4675:
4665:
4655:
4624:
4614:
4565:
4495:
4485:
4446:
4436:
4387:
4346:
4336:
4297:
4287:
4246:
4223:
4179:
4169:
4123:
4113:
4061:
4051:
4012:
4002:
3955:
3947:
3852:
3842:
3834:
3793:
3785:
3750:
3742:
3704:
3694:
3652:
3611:
3603:
3568:
3518:
3510:
3500:
3458:
3412:
3404:
3378:Nature
3358:
3314:
3304:
3270:
3260:
3192:
3182:
3143:
3120:
3110:
3096:: 15.
3064:
3004:
2960:427210
2958:
2950:
2906:
2871:
2864:114758
2861:
2822:
2812:
2763:
2753:
2707:
2639:
2604:
2563:
2553:
2504:
2497:332732
2494:
2446:
2439:318027
2436:
2397:
2356:
2346:
2307:
2300:321884
2297:
2258:
2248:
2206:
2162:207302
2160:
2124:133023
2122:
2025:
2015:
1961:
1951:
1829:
1819:
1767:
1757:
1708:
1664:
1654:
1610:
1600:
1551:WRNIP1
1487:FBXO30
1483:FBXO18
1277:, and
1208:D-loop
1138:(BS),
1132:RECQL4
346:where
207:dimers
118:, and
77:helic-
8009:Types
7740:EF-Tu
7679:SAR1B
7662:RAB27
7657:RAB23
7610:RhoDF
7500:RhoUV
7483:CDC42
7478:Cdc42
7464:>
7449:GNA13
7444:GNA12
7429:GNA11
7418:αq/11
7407:GNAT3
7395:GNAT2
7390:GNAT1
7380:GNAI3
7375:GNAI2
7370:GNAI1
7322:3.6.5
7286:3.6.4
7229:ATP4A
7220:H+/K+
7095:SERCA
7057:3.6.3
7041:3.6.3
7018:3.6.2
6978:3.6.1
6744:2.7.8
6713:Other
6352:2.7.7
6312:2.7.6
6257:2.7.4
6234:2.7.3
6206:2.7.2
6090:Liver
6053:Hexo-
6040:2.7.1
5939:FANCN
5934:FANCJ
5929:FANCI
5912:FANCM
5907:FANCL
5902:FANCG
5897:FANCF
5892:FANCE
5887:FANCC
5882:FANCB
5877:FANCA
5737:ERCC8
5732:ERCC6
5696:RAD51
5617:ERCC1
5401:POLE4
5396:POLE3
5391:POLE2
5374:POLD4
5369:POLD3
5364:POLD2
5359:POLD1
5354:delta
5347:PRIM2
5342:PRIM1
5337:POLA2
5332:POLA1
5327:alpha
5060:PRIM2
5055:PRIM1
5012:SSBP4
5007:SSBP3
5002:SSBP2
3814:Genes
3791:S2CID
3748:S2CID
3609:S2CID
3516:S2CID
3410:S2CID
2956:S2CID
2556:49960
1535:SHPRH
1531:RTEL1
1527:RECQL
1515:IFIH1
1495:HELLS
1475:BRIP1
1467:ASCC3
1462:DHX58
1458:DHX40
1454:DHX37
1442:DDX58
1438:DDX12
1434:DDX11
1430:DDX10
1418:DDX3X
1373:CHD1L
1200:FANCM
1176:in a
1092:TFIIH
774:trans
717:trans
215:than
8101:list
8094:EC7
8088:list
8081:EC6
8075:list
8068:EC5
8062:list
8055:EC4
8049:list
8042:EC3
8036:list
8029:EC2
8023:list
8016:EC1
7800:OPA1
7793:and
7745:EF-G
7735:IF-2
7701:Rheb
7689:ARL6
7674:ARF6
7645:NRAS
7640:KRAS
7635:HRAS
7620:RhoD
7615:RhoF
7561:RhoH
7537:RhoG
7522:Rac1
7510:RhoV
7505:RhoU
7488:TC10
7424:GNAQ
7144:SPCA
6971:3.6)
6883:see
6861:see
6836:see
6210:COOH
6009:2.7)
5825:PcrA
5781:CRY2
5776:CRY1
5711:LexA
5706:Slx4
5701:Sgs1
5674:RecA
5654:MSH2
5649:MLH1
5577:ERCC
5487:DKC1
5482:TERC
5477:TERT
5433:Both
5415:PCNA
5386:POLE
5312:RPA1
5295:FEN1
5283:RFC1
5207:holE
5202:holD
5197:holC
5192:holB
5187:holA
5182:dnaX
5177:dnaT
5172:dnaQ
5167:dnaN
5162:dnaH
5157:dnaE
5152:dnaC
5098:and
5069:Both
5044:HFM1
4974:MCM7
4969:MCM6
4964:MCM5
4959:MCM4
4954:MCM3
4949:MCM2
4937:Cdt1
4930:Cdc6
4921:ORC6
4916:ORC5
4911:ORC4
4906:ORC3
4901:ORC2
4896:ORC1
4858:dnaG
4839:dnaB
4834:dnaA
4822:dnaC
4706:OCLC
4696:ISBN
4673:PMID
4653:ISBN
4622:PMID
4563:PMID
4493:PMID
4444:PMID
4385:PMID
4344:PMID
4295:PMID
4244:ISBN
4221:PMID
4177:PMID
4121:PMID
4059:PMID
4010:PMID
3953:PMID
3945:ISSN
3910:link
3906:link
3899:help
3887:help
3850:PMID
3832:ISSN
3783:PMID
3740:PMID
3702:PMID
3650:PMID
3632:Cell
3601:PMID
3566:PMID
3508:PMID
3456:PMID
3402:PMID
3356:PMID
3312:PMID
3302:ISBN
3268:PMID
3242:Cell
3190:PMID
3141:PMID
3118:PMID
3062:PMID
3002:PMID
2984:Cell
2948:PMID
2904:PMID
2869:PMID
2820:PMID
2761:PMID
2705:PMID
2637:PMID
2602:PMID
2561:PMID
2502:PMID
2444:PMID
2395:PMID
2354:PMID
2305:PMID
2256:PMID
2204:PMID
2158:PMID
2120:PMID
2023:PMID
1959:PMID
1827:PMID
1801:Cell
1765:PMID
1706:PMID
1662:PMID
1608:PMID
1584:2012
1523:PIF1
1519:NAV2
1511:HLTF
1507:HFM1
1503:HELZ
1499:HELQ
1491:HELB
1479:DNA2
1450:DHX9
1446:DHX8
1426:DDX6
1422:DDX5
1405:CHD9
1401:CHD8
1397:CHD7
1393:CHD6
1389:CHD5
1385:CHD4
1381:CHD3
1377:CHD2
1369:CHD1
1198:the
1054:ATRX
1044:ATRX
1041:The
972:UvrD
886:2002
880:1996
874:1992
868:1990
862:1989
856:1989
850:1988
844:1986
838:1986
832:1985
826:1982
820:1978
810:1976
761:and
652:<
565:and
540:and
484:>
191:DnaB
178:and
94:The
81:-ase
7795:MX2
7791:MX1
7711:RGK
7706:Rap
7696:Ran
7669:Arf
7652:Rab
7630:Ras
7588:Rnd
7566:Rho
7517:Rac
7493:TCL
7354:olf
7086:Ca+
6626:PAP
6567:III
6501:/Y
6492:TDT
6473:/X
6465:III
6457:Pfu
6432:/B
6422:Taq
6397:/A
6164:PFP
6134:NAD
5861:WRN
5856:BLM
5820:Ogt
5622:RPA
5592:XPC
5587:XPB
5582:XPA
5080:Ori
4783:to
4663:PMC
4645:doi
4612:PMC
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