208:
55:
370:(other than the single bone lesion). The criteria for extramedullary plasmacytoma are the same but the tumor is located in soft tissue. No bone lesions should be present. Criteria for multiple solitary plasmacytomas (+/- recurrent) are the same except either multiple solitary bone or soft tissue lesions must be present. They may occur as multiple primary tumors or as a recurrence from a previous plasmacytoma.
366:(IMWG) has published criteria for the diagnosis of plasmacytomas. They recognise three distinct entities: SPB, extramedullary plasmacytoma and multiple solitary plasmacytomas (+/- recurrent). The proposed criteria for SPB is the presence of a single bone lesion, normal bone marrow (less than 5% plasma cells), small or no paraprotein, no related organ involvement/damage and a normal
336:
462:
Plasmacytomas are a rare form of cancer. SPB is the most common form of the disease and accounts for 3-5% of all plasma cell malignancies. The median age at diagnosis for all plasmacytomas is 55. Both SPB and extramedullary plasmacytoma are more prevalent in males; with a 2:1 male to female ratio for
128:
of bone (SPB); extramedullary plasmacytoma (EP), and multiple plasmacytomas that are either primary or recurrent. The most common of these is SPB, accounting for 3â5% of all plasma cell malignancies. SPBs occur as lytic lesions within the axial skeleton and extramedullary plasmacytomas most often
440:
treatment. In a study that included 68 patients, a group of 8 patients who were treated with radio- and chemotherapy (with or without surgery) were less likey to have a relapse of plasmacytoma, progress to multiple myeloma, or die compared with patients who were treated with radiotherapy and/or
414:
plasma cells. These cells express products of EBV genes such as EBER1 and EBER2. EBV-positive plasmacytoma(s) is more likely to progress to multiple myeloma than EBV-negative plasmacytoma(s) suggesting that the virus may play a role in the progression of plasmacytoma to multiple myeloma.
453:
within 2â4 years of diagnosis, but the overall median survival for SPB is 7â12 years. 30â50% of extramedullary plasmacytoma cases progress to multiple myeloma with a median time of 1.5â2.5 years. 15â45% of SPB and 50â65% of extramedullary plasmacytoma are disease free after 10 years.
261:
spike. This is due to an outgrowth of a single type of plasma cell that forms the plasmacytoma and produces a single type of antibody. The plasma cells are said to be monoclonal and the excessively produced antibody is known as monoclonal protein or
273:
Bone marrow biopsies are performed to ensure the disease is localised; and in SPB or extramedullary plasmacytoma there will not be an increase of monoclonal plasma cells. Tissue biopsies of SPB and extramedullary plasmacytoma are used to assess the
1292:
1277:
736:
Dimopoulos M, Terpos E, Comenzo RL, et al. (September 2009). "International myeloma working group consensus statement and guidelines regarding the current role of imaging techniques in the diagnosis and monitoring of multiple
Myeloma".
435:
is an option for extramedullary plasmacytoma, but for cosmetic reasons it is generally used when the lesion is not present within the head and neck region. Another option is the possible combination of radiotherapy with
2449:
1418:
426:
is the main choice of treatment for both SPB and extramedullary plasmacytoma, and local control rates of >80% can be achieved. This form of treatment can be used with curative intent because plasmacytoma is a
2193:
403:
399:
475:" or "solitary myeloma". It is often used as part of the phrase "solitary plasmacytoma". or as part of the phrase "extramedullary plasmacytoma". In this context, "extramedullary" means outside of the
253:
Serum protein electrophoresis separates the proteins in the liquid part of the blood (serum), allowing the analysis of antibodies. Normal blood serum contains a range of antibodies and are said to be
1029:
406:. EBV-positivity is more common in plasmacytoma than multiple myeloma. The tissues involved in EBV+ plasmacytoma typically show foci of EBV+ cells with the appearance of rapidly proliferating
1411:
1747:
2528:
943:
Yan J, Wang J, Zhang W, Chen M, Chen J, Liu W (April 2017). "Solitary plasmacytoma associated with
Epstein-Barr virus: a clinicopathologic, cytogenetic study and literature review".
1864:
1404:
1307:
2454:
355:, but they form discrete masses of cells in the skeleton (solitary plasmacytoma of bone; SPB) or in soft tissues (extramedullary plasmacytoma; EP). They do not present with
2263:
1466:
498:
2477:
1829:
441:
surgery alone . Concerning that study, a large prospective trial is needed to evaluate the impact of adding systemic anti-myeloma treatment to local radiotherapy.
2523:
2219:
859:
Sekiguchi Y, Shimada A, Ichikawa K, Wakabayashi M, Sugimoto K, Ikeda K, Sekikawa I, Tomita S, Izumi H, Nakamura N, Sawada T, Ohta Y, Komatsu N, Noguchi M (2015).
1558:
1909:
2422:
812:"Guidelines on the diagnosis and management of solitary plasmacytoma of bone, extramedullary plasmacytoma and multiple solitary plasmacytomas: 2009 update"
861:"EpsteinâBarr virus-positive multiple myeloma developing after immunosuppressant therapy for rheumatoid arthritis: a case report and review of literature"
2461:
2007:
1752:
538:"Criteria for the classification of monoclonal gammopathies, multiple myeloma and related disorders: a report of the International Myeloma Working Group"
1886:
282:(CD) markers are present and to assess monoclonality of the cells. CD markers can aid in the distinction of extramedullary plasmacytoma from lymphomas.
2518:
1987:
1785:
2411:
2085:
1639:
2258:
296:. MRI can be used to assess tumor status and may be advantageous in detecting primary tumors that are not detected by plain film radiography.
2077:
1628:
985:"Clinical features, therapy patterns, outcomes and prognostic factors of solitary plasmacytomas: a report of the Israeli Myeloma Study Group"
843:
504:
2406:
1034:
2362:
1982:
1780:
1664:
363:
121:
2253:
152:. For SPB and extramedullary plasmacytoma the distinction is the presence of only one lesion (either in bone or soft tissue), normal
1551:
1089:
2214:
1208:"Primary extramedullary plasmacytoma: similarities with and differences from multiple myeloma revealed by interphase cytogenetics"
1481:
811:
207:
2444:
2436:
2295:
2173:
2112:
2098:
1992:
1933:
1770:
1696:
2492:
2402:
2352:
2248:
1977:
1761:
223:
211:
2384:
2290:
2273:
2081:
1635:
1544:
1427:
2325:
2198:
1904:
586:"Guidelines on the diagnosis and management of solitary plasmacytoma of bone and solitary extramedullary plasmacytoma"
1250:
398:. EBV-positive multiple myeloma and plasmacytoma are classified together by the World Health Organization (2016) as
2240:
1500:
1488:
900:
Rezk SA, Zhao X, Weiss LM (June 2018). "Epstein - Barr virus - associated lymphoid proliferations, a 2018 update".
780:
O'Connell TX, Horita TJ, Kasravi B (January 2005). "Understanding and interpreting serum protein electrophoresis".
279:
2128:
1969:
1891:
1254:
509:
301:
2330:
2158:
1322:
239:
1796:
141:, but surgery is used in some cases of extramedullary plasmacytoma. The skeletal forms frequently progress to
181:
173:
130:
2347:
1898:
379:
2224:
2203:
2117:
1517:
1384:
1049:
2356:
1946:
1840:
1439:
488:
472:
391:
258:
254:
177:
125:
99:
37:
1919:
1742:
2153:
1765:
1676:
1460:
395:
382:(EBV) is associated with multiple myeloma and plasmacytomas, particularly in individuals who have an
235:
984:
1953:
1737:
1707:
1493:
1296:
320:
231:
2417:
1012:
925:
762:
227:
315:. The difference between plasmacytoma and multiple myeloma is that plasmacytoma lacks increased
1396:
2497:
2167:
2148:
2137:
1927:
1817:
1732:
1477:
1333:
1229:
1188:
1154:
1101:
1070:
1004:
960:
917:
882:
839:
789:
754:
715:
657:
607:
559:
300:
may also be beneficial in detecting extramedullary tumours in individuals diagnosed with SPB.
78:
222:
The diagnosis of plasmacytoma uses a diverse range of interdisciplinary techniques including
2267:
2046:
1914:
1813:
1536:
1525:
1472:
1456:
1219:
1144:
1136:
1062:
996:
952:
909:
872:
746:
705:
695:
647:
597:
549:
493:
450:
437:
428:
383:
356:
352:
312:
308:
149:
142:
31:
471:
There can be some ambiguity when using the word. "Plasmacytoma" is sometimes equated with "
17:
2040:
2035:
1844:
1728:
1594:
1589:
1443:
367:
285:
278:
of the plasma cells. Histological analyses can be performed on these biopsies to see what
157:
134:
1109:
836:
Pathology and
Genetics of Haemo (World Health Organization Classification of Tumours S.)
54:
2487:
1505:
1316:
1312:
1149:
1124:
877:
860:
710:
683:
293:
289:
114:
1301:
956:
2512:
2394:
2093:
2002:
1958:
1775:
1649:
1016:
602:
554:
537:
316:
307:
An important distinction to be made is that a true plasmacytoma is present and not a
929:
766:
652:
635:
1659:
1373:
423:
138:
1000:
913:
70:
1327:
1140:
1090:"Up-date on solitary plasmacytoma and its main differences with multiple myeloma"
214:
of an individual with polyclonal antibodies (top) and an individual with a large
168:
For SPB the most common presenting symptom is that of pain in the affected bone.
133:(85%), but can occur in any soft tissue. Approximately half of all cases produce
1671:
476:
407:
348:
267:
263:
215:
192:
153:
110:
103:
148:
Due to their cellular similarity, plasmacytomas have to be differentiated from
1567:
1338:
1286:
83:
62:
1066:
1368:
1344:
684:"A review for solitary plasmacytoma of bone and extramedullary plasmacytoma"
411:
275:
270:
are present in 60% of SPB and less than 25% of extramedullary plasmacytoma.
188:
169:
1233:
1224:
1207:
1192:
1158:
1105:
1074:
1008:
964:
921:
886:
793:
758:
719:
661:
611:
563:
335:
700:
327:
in the bloodstream, and multiple bone lesions (collectively termed CRAB).
2482:
2310:
2021:
1584:
1571:
1430:
1379:
1173:
1047:
Dimopoulos MA, Moulopoulos LA, Maniatis A, Alexanian R (September 2000).
387:
196:
87:
1269:
750:
432:
27:
Growth of a plasma cell tumour within soft tissue or the axial skeleton
359:, which would classify them as another systemic plasma cell disorder.
2030:
1281:
324:
304:
may be better than plain film radiography for assessing bone damage.
297:
247:
184:
106:
1125:"Immunoglobulin free light chains and solitary plasmacytoma of bone"
585:
1853:
1718:
1702:
344:
334:
206:
1349:
1050:"Solitary plasmacytoma of bone and asymptomatic multiple myeloma"
682:
Kilciksiz S, Karakoyun-Celik O, Agaoglu FY, Haydaroglu A (2012).
2316:
2210:
2189:
2107:
1849:
1824:
1804:
1800:
1687:
1605:
1600:
180:. Around 85% of extramedullary plasmacytoma presents within the
137:. SPBs and extramedullary plasmacytomas are mostly treated with
1540:
1400:
1172:
Megat Shiraz MA, Jong YH, Primuharsa Putra SH (November 2008).
2056:
2051:
1941:
1123:
Dingli D, Kyle RA, Rajkumar SV, et al. (September 2006).
243:
1206:
Bink K, Haralambieva E, Kremer M, et al. (April 2008).
983:
Ganzel C, Trestman S, Levi S, et al. (September 2022).
865:
International
Journal of Clinical and Experimental Pathology
195:
and nasal obstruction. In some tissues it may be found as a
172:
and other consequences of the bone lesion may occur such as
2194:
Non-mycosis fungoides CD30â cutaneous large T-cell lymphoma
257:, whereas serum from a person with plasmacytoma may show a
584:
Soutar R, Lucraft H, Jackson G, et al. (March 2004).
400:
EpsteinâBarr virus-associated lymphoproliferative diseases
805:
803:
463:
SPB and a 3:1 ratio for extramedullary plasmacytoma.
160:, absent or low paraprotein and no end organ damage.
1259:
1174:"Extramedullary plasmacytoma in the maxillary sinus"
810:
M. Hughes; R. Soutar; H. Lucraft; R. Owen; J. Bird.
2470:
2435:
2393:
2375:
2339:
2309:
2282:
2237:
2182:
2136:
2127:
2067:
2029:
2020:
1968:
1878:
1839:
1795:
1717:
1686:
1648:
1627:
1616:
1583:
1515:
1438:
1359:
1263:
77:
47:
2264:Peripheral T-cell lymphoma not otherwise specified
1048:
499:Monoclonal gammopathy of undetermined significance
38:Plasma cell dyscrasia § Solitary plasmacytoma
2086:Precursor T acute lymphoblastic leukemia/lymphoma
1640:Precursor B acute lymphoblastic leukemia/lymphoma
536:International Myeloma Working Group (June 2003).
404:EpsteinâBarr virus-associated plasma cell myeloma
1830:Nodular lymphocyte predominant Hodgkin lymphoma
978:
976:
974:
636:"Solitary bone and extramedullary plasmacytoma"
731:
729:
677:
675:
673:
671:
629:
627:
625:
623:
621:
579:
577:
575:
573:
531:
529:
527:
525:
394:, or a chronic inflammatory condition such as
2220:Secondary cutaneous CD30+ large-cell lymphoma
1552:
1412:
8:
1910:Post-transplant lymphoproliferative disorder
1865:immunoproliferative immunoglobulin disorders
2423:Diffuse infiltrative lymphocytosis syndrome
351:. The cells are identical to those seen in
2462:Jessner lymphocytic infiltrate of the skin
2133:
2064:
2026:
2008:Primary cutaneous follicle center lymphoma
1753:Primary cutaneous follicle center lymphoma
1624:
1613:
1580:
1559:
1545:
1537:
1419:
1405:
1397:
1260:
53:
44:
1223:
1148:
876:
709:
699:
651:
601:
553:
1988:Primary cutaneous marginal zone lymphoma
1786:Primary cutaneous marginal zone lymphoma
2450:with bandlike and perivascular patterns
2412:Autoimmune lymphoproliferative syndrome
521:
374:Association with the EpsteinâBarr virus
2529:EpsteinâBarr virusâassociated diseases
2259:Enteropathy-associated T-cell lymphoma
640:Hematology Am Soc Hematol Educ Program
288:are used to ensure there are no other
2524:Lymphoid-related cutaneous conditions
1088:Di Micco P, Di Micco B (March 2005).
7:
2407:X-linked lymphoproliferative disease
187:, causing possible symptoms such as
2363:Large granular lymphocytic leukemia
1983:Intravascular large B-cell lymphoma
364:International Myeloma Working Group
122:International Myeloma Working Group
25:
957:10.1016/j.anndiagpath.2016.09.002
603:10.1111/j.1365-2141.2004.04834.x
555:10.1046/j.1365-2141.2003.04355.x
2519:Hematologic malignant neoplasms
2215:CD30+ cutaneous T-cell lymphoma
653:10.1182/asheducation-2005.1.373
505:Waldenström's macroglobulinemia
2445:Cutaneous lymphoid hyperplasia
2437:Cutaneous lymphoid hyperplasia
2296:Adult T-cell leukemia/lymphoma
2174:Adult T-cell leukemia/lymphoma
2113:Anaplastic large-cell lymphoma
1993:Primary cutaneous immunocytoma
1934:Splenic marginal zone lymphoma
945:Annals of Diagnostic Pathology
449:Most cases of SPB progress to
311:plasma cell disorder, such as
156:(<5% plasma cells), normal
145:over the course of 2â4 years.
1:
2493:Lymphoproliferative disorders
2403:Lymphoproliferative disorders
2353:Extranodal NK-T-cell lymphoma
2225:Lymphomatoid papulosis type A
2204:Lymphomatoid papulosis type B
2118:Lymphomatoid papulosis type A
1978:Diffuse large B-cell lymphoma
1482:Waldenström macroglobulinemia
1001:10.1080/10428194.2022.2118535
914:10.1016/j.humpath.2018.05.020
339:Micrograph of a plasmacytoma.
224:serum protein electrophoresis
212:Serum protein electrophoresis
2385:Acute biphenotypic leukaemia
2274:Subcutaneous T-cell lymphoma
1141:10.1182/blood-2006-04-015784
1035:Dorland's Medical Dictionary
2326:Aggressive NK-cell leukemia
2199:Pleomorphic T-cell lymphoma
1905:Lymphomatoid granulomatosis
18:Extramedullary plasmacytoma
2545:
280:cluster of differentiation
35:
29:
1579:
1255:National Cancer Institute
510:Cutaneous B-cell lymphoma
321:decreased kidney function
61:
52:
2478:Hematological malignancy
2331:Blastic NK cell lymphoma
2159:Granulomatous slack skin
1915:Classic Hodgkin lymphoma
1814:Classic Hodgkin lymphoma
1067:10.1182/blood.V96.6.2037
838:. Oxford Univ Pr. 2003.
325:too few red blood cells
182:upper respiratory tract
174:spinal cord compression
131:upper respiratory tract
1518:hypergammaglobulinemia
1225:10.3324/haematol.12005
688:ScientificWorldJournal
340:
240:plain film radiography
219:
2357:Angiocentric lymphoma
1947:AIDS-related lymphoma
1771:Splenic marginal zone
489:Plasma cell dyscrasia
473:plasma cell dyscrasia
412:poorly differentiated
392:organ transplantation
338:
230:, urine analysis for
210:
178:pathological fracture
126:solitary plasmacytoma
100:plasma cell dyscrasia
2455:with nodular pattern
2154:Pagetoid reticulosis
1766:marginal zone B-cell
1461:Plasma cell leukemia
396:rheumatoid arthritis
236:complete blood count
1954:Helicobacter pylori
1781:Nodal marginal zone
1708:Hairy cell leukemia
1574:and related disease
1506:Primary amyloidosis
1494:Heavy chain disease
1428:Immunoproliferative
751:10.1038/leu.2009.89
701:10.1100/2012/895765
232:Bence Jones protein
124:lists three types:
2498:Lymphoid leukemias
2418:Leukemoid reaction
2254:Angioimmunoblastic
1920:Burkitt's lymphoma
1360:External resources
380:EpsteinâBarr virus
343:Plasmacytoma is a
341:
228:bone marrow biopsy
220:
164:Signs and symptoms
2506:
2505:
2431:
2430:
2371:
2370:
2305:
2304:
2233:
2232:
2149:Mycosis fungoides
2016:
2015:
1874:
1873:
1818:Nodular sclerosis
1733:follicular B cell
1534:
1533:
1478:Macroglobulinemia
1394:
1393:
995:(14): 3448â3455.
845:978-92-832-2411-2
634:Weber DM (2005).
93:
92:
42:Medical condition
16:(Redirected from
2536:
2268:Lennert lymphoma
2134:
2065:
2027:
1892:Primary effusion
1625:
1614:
1581:
1561:
1554:
1547:
1538:
1526:Cryoglobulinemia
1457:Multiple myeloma
1421:
1414:
1407:
1398:
1261:
1238:
1237:
1227:
1203:
1197:
1196:
1178:
1169:
1163:
1162:
1152:
1120:
1114:
1113:
1108:. Archived from
1085:
1079:
1078:
1052:
1044:
1038:
1027:
1021:
1020:
980:
969:
968:
940:
934:
933:
897:
891:
890:
880:
856:
850:
849:
832:
826:
825:
823:
821:
816:
807:
798:
797:
782:Am Fam Physician
777:
771:
770:
733:
724:
723:
713:
703:
679:
666:
665:
655:
631:
616:
615:
605:
581:
568:
567:
557:
533:
494:Multiple myeloma
451:multiple myeloma
438:multiple myeloma
384:immunodeficiency
357:systemic disease
353:multiple myeloma
313:multiple myeloma
286:Skeletal surveys
150:multiple myeloma
143:multiple myeloma
57:
45:
32:Multiple myeloma
21:
2544:
2543:
2539:
2538:
2537:
2535:
2534:
2533:
2509:
2508:
2507:
2502:
2466:
2427:
2389:
2377:
2367:
2335:
2314:
2301:
2278:
2239:
2229:
2178:
2123:
2071:
2069:
2044:
2039:
2033:
2012:
1964:
1870:
1847:
1835:
1791:
1729:germinal center
1713:
1682:
1644:
1620:
1618:
1598:
1593:
1587:
1575:
1565:
1535:
1530:
1511:
1434:
1425:
1395:
1390:
1389:
1355:
1354:
1272:
1247:
1242:
1241:
1205:
1204:
1200:
1181:Singapore Med J
1176:
1171:
1170:
1166:
1122:
1121:
1117:
1087:
1086:
1082:
1046:
1045:
1041:
1028:
1024:
982:
981:
972:
942:
941:
937:
902:Human Pathology
899:
898:
894:
871:(2): 2090â102.
858:
857:
853:
846:
834:
833:
829:
819:
817:
814:
809:
808:
801:
779:
778:
774:
735:
734:
727:
681:
680:
669:
633:
632:
619:
590:Br. J. Haematol
583:
582:
571:
542:Br. J. Haematol
535:
534:
523:
518:
485:
469:
460:
447:
421:
376:
368:skeletal survey
333:
205:
166:
158:skeletal survey
135:paraproteinemia
43:
40:
34:
28:
23:
22:
15:
12:
11:
5:
2542:
2540:
2532:
2531:
2526:
2521:
2511:
2510:
2504:
2503:
2501:
2500:
2495:
2490:
2488:Leukemia cutis
2485:
2480:
2474:
2472:
2468:
2467:
2465:
2464:
2459:
2458:
2457:
2452:
2441:
2439:
2433:
2432:
2429:
2428:
2426:
2425:
2420:
2415:
2409:
2399:
2397:
2391:
2390:
2388:
2387:
2381:
2379:
2373:
2372:
2369:
2368:
2366:
2365:
2360:
2343:
2341:
2337:
2336:
2334:
2333:
2328:
2322:
2320:
2307:
2306:
2303:
2302:
2300:
2299:
2286:
2284:
2280:
2279:
2277:
2276:
2271:
2261:
2256:
2251:
2245:
2243:
2235:
2234:
2231:
2230:
2228:
2227:
2222:
2217:
2207:
2206:
2201:
2196:
2186:
2184:
2180:
2179:
2177:
2176:
2168:SĂ©zary disease
2162:
2161:
2156:
2151:
2142:
2140:
2131:
2125:
2124:
2122:
2121:
2115:
2103:
2102:
2099:Prolymphocytic
2089:
2075:
2073:
2062:
2061:
2060:
2054:
2024:
2018:
2017:
2014:
2013:
2011:
2010:
2005:
2000:
1995:
1990:
1985:
1980:
1974:
1972:
1966:
1965:
1963:
1962:
1950:
1938:
1937:
1936:
1924:
1923:
1922:
1917:
1912:
1907:
1895:
1882:
1880:
1876:
1875:
1872:
1871:
1869:
1868:
1859:
1857:
1837:
1836:
1834:
1833:
1821:
1810:
1808:
1793:
1792:
1790:
1789:
1783:
1778:
1773:
1757:
1756:
1750:
1745:
1740:
1724:
1722:
1715:
1714:
1712:
1711:
1699:
1697:Prolymphocytic
1693:
1691:
1684:
1683:
1681:
1680:
1668:
1655:
1653:
1646:
1645:
1643:
1633:
1631:
1622:
1611:
1610:
1609:
1577:
1576:
1566:
1564:
1563:
1556:
1549:
1541:
1532:
1531:
1529:
1528:
1522:
1520:
1513:
1512:
1510:
1509:
1497:
1485:
1469:
1464:
1454:
1448:
1446:
1436:
1435:
1431:immunoglobulin
1426:
1424:
1423:
1416:
1409:
1401:
1392:
1391:
1388:
1387:
1376:
1364:
1363:
1361:
1357:
1356:
1353:
1352:
1341:
1330:
1319:
1304:
1289:
1273:
1268:
1267:
1265:
1264:Classification
1258:
1257:
1246:
1245:External links
1243:
1240:
1239:
1198:
1187:(11): e310â1.
1164:
1135:(6): 1979â83.
1115:
1112:on 2009-01-07.
1080:
1061:(6): 2037â44.
1039:
1030:"plasmacytoma"
1022:
970:
935:
892:
851:
844:
827:
799:
772:
745:(9): 1545â56.
725:
667:
617:
569:
520:
519:
517:
514:
513:
512:
507:
502:
496:
491:
484:
481:
468:
465:
459:
456:
446:
443:
429:radiosensitive
420:
417:
375:
372:
332:
331:Classification
329:
294:axial skeleton
290:primary tumors
204:
201:
165:
162:
115:axial skeleton
113:or within the
91:
90:
81:
75:
74:
59:
58:
50:
49:
41:
26:
24:
14:
13:
10:
9:
6:
4:
3:
2:
2541:
2530:
2527:
2525:
2522:
2520:
2517:
2516:
2514:
2499:
2496:
2494:
2491:
2489:
2486:
2484:
2481:
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2476:
2475:
2473:
2469:
2463:
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2456:
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2451:
2448:
2447:
2446:
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2442:
2440:
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2434:
2424:
2421:
2419:
2416:
2413:
2410:
2408:
2404:
2401:
2400:
2398:
2396:
2395:Lymphocytosis
2392:
2386:
2383:
2382:
2380:
2374:
2364:
2361:
2358:
2354:
2350:
2349:
2345:
2344:
2342:
2338:
2332:
2329:
2327:
2324:
2323:
2321:
2318:
2312:
2308:
2297:
2293:
2292:
2288:
2287:
2285:
2281:
2275:
2272:
2269:
2265:
2262:
2260:
2257:
2255:
2252:
2250:
2249:Hepatosplenic
2247:
2246:
2244:
2242:
2236:
2226:
2223:
2221:
2218:
2216:
2212:
2209:
2208:
2205:
2202:
2200:
2197:
2195:
2191:
2188:
2187:
2185:
2181:
2175:
2172:
2171:
2170:
2169:
2166:
2160:
2157:
2155:
2152:
2150:
2147:
2144:
2143:
2141:
2139:
2135:
2132:
2130:
2126:
2119:
2116:
2114:
2110:
2109:
2105:
2104:
2100:
2096:
2095:
2094:prolymphocyte
2091:
2090:
2087:
2083:
2079:
2076:
2074:
2066:
2063:
2058:
2055:
2053:
2050:
2049:
2048:
2042:
2037:
2032:
2028:
2025:
2023:
2019:
2009:
2006:
2004:
2003:Plasmacytosis
2001:
1999:
1996:
1994:
1991:
1989:
1986:
1984:
1981:
1979:
1976:
1975:
1973:
1971:
1967:
1960:
1959:MALT lymphoma
1956:
1955:
1951:
1948:
1944:
1943:
1939:
1935:
1932:
1931:
1930:
1929:
1925:
1921:
1918:
1916:
1913:
1911:
1908:
1906:
1903:
1902:
1901:
1900:
1896:
1893:
1889:
1888:
1884:
1883:
1881:
1877:
1867:
1866:
1861:
1860:
1858:
1855:
1851:
1846:
1842:
1838:
1831:
1827:
1826:
1822:
1819:
1815:
1812:
1811:
1809:
1806:
1802:
1798:
1794:
1787:
1784:
1782:
1779:
1777:
1774:
1772:
1768:
1767:
1763:
1762:marginal zone
1759:
1758:
1754:
1751:
1749:
1746:
1744:
1741:
1739:
1735:
1734:
1730:
1726:
1725:
1723:
1720:
1716:
1709:
1705:
1704:
1700:
1698:
1695:
1694:
1692:
1689:
1685:
1678:
1674:
1673:
1669:
1666:
1662:
1661:
1657:
1656:
1654:
1651:
1647:
1641:
1637:
1634:
1632:
1630:
1626:
1623:
1615:
1612:
1607:
1604:
1603:
1602:
1596:
1591:
1586:
1582:
1578:
1573:
1569:
1562:
1557:
1555:
1550:
1548:
1543:
1542:
1539:
1527:
1524:
1523:
1521:
1519:
1514:
1507:
1503:
1502:
1498:
1495:
1491:
1490:
1486:
1483:
1479:
1475:
1474:
1470:
1468:
1465:
1462:
1458:
1455:
1453:
1450:
1449:
1447:
1445:
1441:
1437:
1432:
1429:
1422:
1417:
1415:
1410:
1408:
1403:
1402:
1399:
1386:
1382:
1381:
1377:
1375:
1371:
1370:
1366:
1365:
1362:
1358:
1351:
1347:
1346:
1342:
1340:
1336:
1335:
1331:
1329:
1325:
1324:
1320:
1318:
1314:
1310:
1309:
1305:
1303:
1299:
1298:
1294:
1290:
1288:
1284:
1283:
1279:
1275:
1274:
1271:
1266:
1262:
1256:
1252:
1249:
1248:
1244:
1235:
1231:
1226:
1221:
1217:
1213:
1212:Haematologica
1209:
1202:
1199:
1194:
1190:
1186:
1182:
1175:
1168:
1165:
1160:
1156:
1151:
1146:
1142:
1138:
1134:
1130:
1126:
1119:
1116:
1111:
1107:
1103:
1099:
1095:
1091:
1084:
1081:
1076:
1072:
1068:
1064:
1060:
1056:
1051:
1043:
1040:
1037:
1036:
1031:
1026:
1023:
1018:
1014:
1010:
1006:
1002:
998:
994:
990:
989:Leuk Lymphoma
986:
979:
977:
975:
971:
966:
962:
958:
954:
950:
946:
939:
936:
931:
927:
923:
919:
915:
911:
907:
903:
896:
893:
888:
884:
879:
874:
870:
866:
862:
855:
852:
847:
841:
837:
831:
828:
813:
806:
804:
800:
795:
791:
788:(1): 105â12.
787:
783:
776:
773:
768:
764:
760:
756:
752:
748:
744:
740:
732:
730:
726:
721:
717:
712:
707:
702:
697:
693:
689:
685:
678:
676:
674:
672:
668:
663:
659:
654:
649:
645:
641:
637:
630:
628:
626:
624:
622:
618:
613:
609:
604:
599:
596:(6): 717â26.
595:
591:
587:
580:
578:
576:
574:
570:
565:
561:
556:
551:
548:(5): 749â57.
547:
543:
539:
532:
530:
528:
526:
522:
515:
511:
508:
506:
503:
500:
497:
495:
492:
490:
487:
486:
482:
480:
478:
474:
466:
464:
457:
455:
452:
444:
442:
439:
434:
430:
425:
418:
416:
413:
409:
405:
401:
397:
393:
389:
385:
381:
373:
371:
369:
365:
360:
358:
354:
350:
346:
337:
330:
328:
326:
322:
318:
317:blood calcium
314:
310:
305:
303:
299:
295:
291:
287:
283:
281:
277:
271:
269:
265:
260:
256:
251:
249:
245:
241:
237:
233:
229:
225:
217:
213:
209:
202:
200:
198:
197:palpable mass
194:
190:
186:
183:
179:
175:
171:
163:
161:
159:
155:
151:
146:
144:
140:
136:
132:
129:occur in the
127:
123:
118:
116:
112:
109:grows within
108:
105:
101:
97:
89:
85:
82:
80:
76:
72:
71:H&E stain
68:
64:
60:
56:
51:
46:
39:
33:
19:
2346:
2289:
2283:By infection
2164:
2163:
2145:
2106:
2092:
2070:development/
1998:Plasmacytoma
1997:
1952:
1940:
1926:
1897:
1885:
1879:By infection
1862:
1823:
1760:
1727:
1701:
1670:
1660:naive B cell
1658:
1619:development/
1499:
1487:
1471:
1452:Plasmacytoma
1451:
1378:
1367:
1343:
1332:
1321:
1306:
1291:
1276:
1218:(4): 623â6.
1215:
1211:
1201:
1184:
1180:
1167:
1132:
1128:
1118:
1110:the original
1097:
1093:
1083:
1058:
1054:
1042:
1033:
1025:
992:
988:
948:
944:
938:
905:
901:
895:
868:
864:
854:
835:
830:
818:. Retrieved
785:
781:
775:
742:
738:
691:
687:
643:
639:
593:
589:
545:
541:
470:
461:
458:Epidemiology
448:
424:Radiotherapy
422:
386:due to e.g.
378:Rarely, the
377:
361:
349:plasma cells
342:
306:
284:
272:
268:Paraproteins
252:
221:
167:
147:
139:radiotherapy
119:
96:Plasmacytoma
95:
94:
67:plasmacytoma
66:
48:Plasmacytoma
2165:aggressive:
2138:MF+variants
1677:Mantle cell
1672:mantle zone
1501:light chain
1489:heavy chain
1100:(1): 7â12.
477:bone marrow
467:Terminology
402:and termed
292:within the
264:paraprotein
216:paraprotein
193:rhinorrhoea
154:bone marrow
111:soft tissue
104:plasma cell
102:in which a
2513:Categories
2241:peripheral
1738:Follicular
1568:Leukaemias
1334:DiseasesDB
1094:Exp. Oncol
820:January 2,
516:References
302:CT imaging
259:monoclonal
255:polyclonal
84:Hematology
63:Micrograph
36:See also:
30:See also:
2376:Lymphoid+
2146:indolent:
2129:Cutaneous
1970:Cutaneous
1748:GCB DLBCL
1743:Burkitt's
1572:lymphomas
1433:disorders
1369:eMedicine
1345:SNOMED CT
1017:252161148
908:: 18â41.
646:: 373â6.
445:Prognosis
419:Treatment
276:phenotype
218:(bottom).
203:Diagnosis
189:epistaxis
170:Back pain
79:Specialty
2483:leukemia
2041:leukemia
2036:lymphoma
1595:leukemia
1590:lymphoma
1380:Orphanet
1374:med/2532
1350:10639003
1251:Overview
1234:18326524
1193:19037537
1159:16741249
1106:15812350
1075:10979944
1009:36075048
965:28325354
930:47010934
922:29885408
887:25973110
794:15663032
767:13264295
759:19421229
739:Leukemia
720:22654647
662:16304406
612:15009059
564:12780789
483:See also
408:immature
388:HIV/AIDS
309:systemic
88:oncology
2471:General
2378:myeloid
2340:T or NK
2311:NK cell
1665:CLL/SLL
1328:D010954
1317:M9734/3
1313:M9731/3
1150:1895544
951:: 1â6.
878:4396324
711:3354668
694:: 1â6.
433:Surgery
431:tumor.
2315:(most
2291:HTLV-1
2183:Non-MF
2072:marker
2045:(most
2031:T cell
1703:CD11c+
1621:marker
1599:(most
1585:B cell
1516:Other
1232:
1191:
1157:
1147:
1104:
1073:
1015:
1007:
963:
928:
920:
885:
875:
842:
792:
765:
757:
718:
708:
660:
610:
562:
501:(MGUS)
298:PET-CT
248:PET-CT
185:mucosa
107:tumour
2238:Other
2108:CD30+
1854:CD138
1825:CD20+
1719:CD79a
1385:86855
1308:ICD-O
1302:238.6
1287:C90.2
1177:(PDF)
1129:Blood
1055:Blood
1013:S2CID
926:S2CID
815:(PDF)
763:S2CID
436:anti-
345:tumor
98:is a
65:of a
2317:CD56
2211:CD30
2190:CD30
2078:TdT+
2022:T/NK
1887:KSHV
1863:see
1850:CD38
1841:PCDs
1805:CD30
1801:CD15
1776:MALT
1688:CD22
1629:TdT+
1606:CD20
1601:CD19
1467:MGUS
1440:PCDs
1339:8628
1323:MeSH
1297:9-CM
1230:PMID
1189:PMID
1155:PMID
1102:PMID
1071:PMID
1005:PMID
961:PMID
918:PMID
883:PMID
840:ISBN
822:2019
790:PMID
755:PMID
716:PMID
692:2012
658:PMID
644:2005
608:PMID
560:PMID
362:The
246:and
234:and
120:The
86:and
2348:EBV
2213:+:
2192:-:
2082:ALL
2057:CD8
2052:CD4
2047:CD3
1942:HIV
1928:HCV
1899:EBV
1803:+,
1650:CD5
1636:ALL
1473:IgM
1293:ICD
1278:ICD
1253:at
1220:doi
1145:PMC
1137:doi
1133:108
1063:doi
1032:at
997:doi
953:doi
910:doi
873:PMC
747:doi
706:PMC
696:doi
648:doi
598:doi
594:124
550:doi
546:121
410:or
347:of
266:.
244:MRI
176:or
2515::
2080::
2068:By
1856:+)
1852:+/
1845:PP
1807:+)
1797:RS
1617:By
1570:,
1444:PP
1383::
1372::
1348::
1337::
1326::
1315:,
1311::
1300::
1285::
1282:10
1228:.
1216:93
1214:.
1210:.
1185:49
1183:.
1179:.
1153:.
1143:.
1131:.
1127:.
1098:27
1096:.
1092:.
1069:.
1059:96
1057:.
1053:.
1011:.
1003:.
993:63
991:.
987:.
973:^
959:.
949:27
947:.
924:.
916:.
906:79
904:.
881:.
867:.
863:.
802:^
786:71
784:.
761:.
753:.
743:23
741:.
728:^
714:.
704:.
690:.
686:.
670:^
656:.
642:.
638:.
620:^
606:.
592:.
588:.
572:^
558:.
544:.
540:.
524:^
479:.
390:,
323:,
319:,
250:.
242:,
238:,
226:,
199:.
191:,
117:.
69:.
2414:)
2405:(
2359:)
2355:/
2351:(
2319:)
2313:/
2298:)
2294:(
2270:)
2266:(
2120:)
2111:(
2101:)
2097:(
2088:)
2084:(
2059:)
2043:)
2038:,
2034:(
1961:)
1957:(
1949:)
1945:(
1894:)
1890:(
1848:(
1843:/
1832:)
1828:(
1820:)
1816:(
1799:(
1788:)
1769:(
1764:/
1755:)
1736:(
1731:/
1721:+
1710:)
1706:(
1690:+
1679:)
1675:(
1667:)
1663:(
1652:+
1642:)
1638:(
1608:)
1597:)
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1588:(
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1553:t
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1504:(
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1492:(
1484:)
1480:/
1476:(
1463:)
1459:(
1442:/
1420:e
1413:t
1406:v
1295:-
1280:-
1270:D
1236:.
1222::
1195:.
1161:.
1139::
1077:.
1065::
1019:.
999::
967:.
955::
932:.
912::
889:.
869:8
848:.
824:.
796:.
769:.
749::
722:.
698::
664:.
650::
614:.
600::
566:.
552::
73:.
20:)
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