242:
219:
116:
141:
248:
147:
1118:-mediated signal pathways. Additionally, ECSIT appears to contribute to bactericidal activity in TLR signaling through its interaction with tumor necrosis factor receptor-associated factor 6 (
255:
154:
1668:
Hendrickson SL, Lautenberger JA, Chinn LW, Malasky M, Sezgin E, Kingsley LA, Goedert JJ, Kirk GD, Gomperts ED, Buchbinder SP, Troyer JL, O'Brien SJ (September 2010).
1330:
Vogel RO, Janssen RJ, van den Brand MA, Dieteren CE, Verkaart S, Koopman WJ, Willems PH, Pluk W, van den Heuvel LP, Smeitink JA, Nijtmans LG (March 2007).
1724:
687:
668:
77:
1302:"ECSIT - Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial precursor - Homo sapiens (Human) - ECSIT gene & protein"
1142:) to VISA. The bridging of these receptors to VISA is an important signaling event used in innate antiviral responses. Apart from inflammatory and
1485:
Kondo T, Watanabe M, Hatakeyama S (June 2012). "TRIM59 interacts with ECSIT and negatively regulates NF-κB and IRF-3/7-mediated signal pathways".
1332:"Cytosolic signaling protein Ecsit also localizes to mitochondria where it interacts with chaperone NDUFAF1 and functions in complex I assembly"
1744:
1278:
1260:
241:
927:
934:
218:
1404:
1175:
1247:
1226:
1095:
140:
115:
1243:
1222:
57:
254:
153:
1126:
of ECSIT has shown itself to be necessary for the activation of p65/p50 NF-κBs in TLR4 signaling. Functioning as a
1099:
1638:
247:
146:
732:
65:
1102:. ECSIT plays a regulatory role as part of the TAK1-ECSIT-TRAF6 complex that is involved in the activation of
1749:
713:
1438:"Ubiquitination of ECSIT is crucial for the activation of p65/p50 NF-κBs in Toll-like receptor 4 signaling"
1155:
1020:
129:
1681:
44:
1186:
1147:
1131:
906:
902:
877:
873:
869:
839:
835:
814:
810:
806:
1520:
1162:) assembly and stabilization. Finally, it is important to note that ECSIT is required for normal
1091:
89:
910:
881:
843:
802:
1709:
1620:
1591:"ECSIT bridges RIG-I-like receptors to VISA in signaling events of innate antiviral responses"
1571:
1512:
1467:
1361:
37:
1699:
1689:
1610:
1602:
1561:
1551:
1502:
1494:
1457:
1449:
1351:
1343:
1127:
1039:
334:
265:
209:
164:
85:
1143:
309:
1685:
1704:
1669:
1615:
1590:
1566:
1539:
1462:
1437:
1356:
1331:
1087:
987:
Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial (ECSIT),
602:
597:
592:
587:
571:
566:
561:
556:
551:
546:
530:
525:
1738:
1728:
1412:
1163:
1151:
1075:
1043:
1017:
1013:
512:
1670:"Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression"
1524:
69:
1009:
327:
106:
1694:
93:
1540:"TAK1-ECSIT-TRAF6 complex plays a key role in the TLR4 signal to activate NF-κB"
1405:"Cardiac Organellar Protein Atlas Knowledgebase (COPaKB) —— Protein Information"
1380:"ECSIT ECSIT signalling integrator [Homo sapiens (human)] - Gene - NCBI"
1283:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1265:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1498:
1154:. Through this interaction, ECSIT is demonstrated to play an important role in
410:
1110:
signal and through its interactions with TRIM59 to negatively regulate NF-κB,
1071:
1055:
226:
123:
73:
1556:
1453:
1159:
1123:
1067:
1024:
632:
470:
348:
293:
280:
192:
179:
81:
1713:
1624:
1575:
1516:
1471:
1365:
1379:
974:
969:
1301:
1103:
1059:
958:
777:
758:
1201:, and is a part of the mitochondrial complex I assembly (MCIA) complex.
1538:
Wi SM, Moon G, Kim J, Kim ST, Shim JH, Chun E, Lee KY (December 2014).
1347:
1190:
1005:
994:
744:
699:
1606:
1507:
1194:
1063:
942:
654:
1146:, ECSIT, in its 45 kDa, mitochondrial form helps maintain assembly
1198:
1182:
1135:
1119:
1589:
Lei CQ, Zhang Y, Li M, Jiang LQ, Zhong B, Kim YH, Shu HB (2015).
617:
613:
48:, SITPEC, ECSIT signalling integrator, ECSIT signaling integrator
1139:
1115:
1111:
1107:
1078:
where only the 45 kDa mitochondrial ECSIT is found to interact.
1047:
1001:
61:
1436:
Mi Wi S, Park J, Shim JH, Chun E, Lee KY (January 2015).
317:
1639:"136 binary interactions found for search term ECSIT"
482:
1487:
895:
862:
828:
795:
1239:
1237:
1235:
1218:
1216:
1214:
603:mitochondrial respiratory chain complex I assembly
1178:, with 53 of them being co-complex interactions.
1130:, ECSIT is also essential for the association of
264:
163:
1086:ECSIT has been found to play multiple roles in
1074:targeting signal that causes it to localize to
1054:gene produces a 49 kDa protein composed of 431
16:Protein-coding gene in the species Homo sapiens
1244:GRCm38: Ensembl release 89: ENSMUSG00000066839
8:
1223:GRCh38: Ensembl release 89: ENSG00000130159
1725:United States National Library of Medicine
628:
526:oxidoreductase activity, acting on NAD(P)H
508:
305:
204:
101:
1703:
1693:
1614:
1565:
1555:
1506:
1461:
1355:
1723:This article incorporates text from the
1016:, and the assembly and stabilization of
1210:
1193:interactions, ECSIT can interact with
18:
1643:IntAct Molecular Interaction Database
598:regulation of oxidoreductase activity
269:
230:
225:
168:
127:
122:
7:
1431:
1429:
1325:
1323:
1321:
1296:
1294:
1292:
1058:. ECSIT's interactions with p65/p50
1544:The Journal of Biological Chemistry
892:
859:
825:
792:
768:
749:
723:
704:
678:
659:
487:
405:
343:
322:
14:
1150:NDUFAF1's stable presence in the
997:that in humans is encoded by the
253:
246:
240:
217:
152:
145:
139:
114:
1090:, including those that utilize
1156:NADH:ubiquinone oxidoreductase
1021:NADH:ubiquinone oxidoreductase
471:More reference expression data
1:
1442:Molecular Biology of the Cell
238:
137:
1745:Genes on human chromosome 19
1695:10.1371/journal.pone.0012862
1176:protein-protein interactions
1008:adaptor protein involved in
552:mitochondrial inner membrane
1046:in position 13.2 and has 9
1766:
1595:Journal of Innate Immunity
1499:10.1016/j.bbrc.2012.05.028
449:sternocleidomastoid muscle
379:mucosa of transverse colon
1279:"Mouse PubMed Reference:"
1261:"Human PubMed Reference:"
1070:. ECSIT also contains an
1062:proteins is dependent on
973:
968:
964:
957:
941:
922:
899:
866:
855:
832:
799:
788:
775:
771:
756:
752:
743:
730:
726:
711:
707:
698:
685:
681:
666:
662:
653:
638:
631:
627:
611:
511:
507:
495:
490:
481:
468:
417:
408:
355:
346:
316:
308:
304:
287:
274:
237:
216:
207:
203:
186:
173:
136:
113:
104:
100:
55:
52:
42:
35:
30:
26:
21:
928:Chr 19: 11.51 – 11.53 Mb
1557:10.1074/jbc.M114.597187
1454:10.1091/mbc.E14-08-1277
1409:amino.heartproteome.org
1336:Genes & Development
421:interventricular septum
1010:inflammatory responses
593:innate immune response
457:triceps brachii muscle
433:skeletal muscle tissue
1181:In addition to TAK1,
1164:embryonic development
1014:embryonic development
588:immune system process
130:Chromosome 19 (human)
1187:RIG-I-like receptors
1132:RIG-I-like receptors
935:Chr 9: 21.98 – 22 Mb
367:gastrocnemius muscle
232:Chromosome 9 (mouse)
1686:2010PLoSO...512862H
1092:Toll-like receptors
395:right lobe of liver
1727:, which is in the
1348:10.1101/gad.408407
1038:is located on the
733:ENSMUSG00000066839
581:Biological process
540:Cellular component
519:Molecular function
453:extraocular muscle
387:right frontal lobe
1607:10.1159/000365971
984:
983:
980:
979:
953:
952:
918:
917:
889:
888:
851:
850:
822:
821:
784:
783:
765:
764:
739:
738:
720:
719:
694:
693:
675:
674:
623:
622:
503:
502:
499:
498:
477:
476:
464:
463:
402:
401:
300:
299:
199:
198:
94:ECSIT - orthologs
1757:
1717:
1707:
1697:
1654:
1653:
1651:
1650:
1635:
1629:
1628:
1618:
1586:
1580:
1579:
1569:
1559:
1550:(51): 35205–14.
1535:
1529:
1528:
1510:
1482:
1476:
1475:
1465:
1433:
1424:
1423:
1421:
1420:
1411:. Archived from
1400:
1394:
1393:
1391:
1390:
1384:ncbi.nlm.nih.gov
1376:
1370:
1369:
1359:
1327:
1316:
1315:
1313:
1312:
1298:
1287:
1286:
1275:
1269:
1268:
1257:
1251:
1241:
1230:
1220:
1144:immune responses
1128:scaffold protein
1122:). Importantly,
966:
965:
937:
930:
913:
893:
884:
860:
856:RefSeq (protein)
846:
826:
817:
793:
769:
750:
724:
705:
679:
660:
629:
509:
488:
473:
445:digastric muscle
413:
411:Top expressed in
406:
391:body of pancreas
351:
349:Top expressed in
344:
323:
306:
296:
283:
272:
257:
250:
244:
233:
221:
205:
195:
182:
171:
156:
149:
143:
132:
118:
102:
96:
47:
40:
19:
1765:
1764:
1760:
1759:
1758:
1756:
1755:
1754:
1735:
1734:
1720:
1667:
1663:
1661:Further reading
1658:
1657:
1648:
1646:
1637:
1636:
1632:
1588:
1587:
1583:
1537:
1536:
1532:
1484:
1483:
1479:
1435:
1434:
1427:
1418:
1416:
1402:
1401:
1397:
1388:
1386:
1378:
1377:
1373:
1329:
1328:
1319:
1310:
1308:
1300:
1299:
1290:
1277:
1276:
1272:
1259:
1258:
1254:
1242:
1233:
1221:
1212:
1207:
1202:
1172:
1084:
1033:
975:View/Edit Mouse
970:View/Edit Human
933:
926:
923:Location (UCSC)
909:
905:
901:
880:
876:
872:
868:
842:
838:
834:
813:
809:
805:
801:
714:ENSG00000130159
607:
576:
535:
531:protein binding
469:
460:
455:
451:
447:
443:
441:right ventricle
439:
437:temporal muscle
435:
431:
427:
425:muscle of thigh
423:
409:
398:
393:
389:
385:
383:body of stomach
381:
377:
373:
371:muscle of thigh
369:
365:
361:
347:
291:
278:
270:
260:
259:
258:
251:
231:
208:Gene location (
190:
177:
169:
159:
158:
157:
150:
128:
105:Gene location (
56:
43:
36:
17:
12:
11:
5:
1763:
1761:
1753:
1752:
1750:Human proteins
1747:
1737:
1736:
1719:
1718:
1664:
1662:
1659:
1656:
1655:
1630:
1581:
1530:
1477:
1425:
1395:
1371:
1317:
1288:
1270:
1252:
1231:
1209:
1208:
1206:
1203:
1180:
1174:ECSIT has 136
1171:
1168:
1124:ubiquitination
1088:cell-signaling
1083:
1080:
1068:ubiquitination
1032:
1029:
989:also known as
982:
981:
978:
977:
972:
962:
961:
955:
954:
951:
950:
948:
946:
939:
938:
931:
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920:
919:
916:
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896:
890:
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886:
864:
863:
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852:
849:
848:
830:
829:
823:
820:
819:
797:
796:
790:
786:
785:
782:
781:
773:
772:
766:
763:
762:
754:
753:
747:
741:
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737:
736:
728:
727:
721:
718:
717:
709:
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702:
696:
695:
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691:
683:
682:
676:
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672:
664:
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657:
651:
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635:
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624:
621:
620:
609:
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605:
600:
595:
590:
584:
582:
578:
577:
575:
574:
569:
564:
559:
554:
549:
543:
541:
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536:
534:
533:
528:
522:
520:
516:
515:
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504:
501:
500:
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485:
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415:
414:
403:
400:
399:
397:
396:
392:
388:
384:
380:
376:
372:
368:
364:
363:left ventricle
360:
356:
353:
352:
340:
339:
331:
320:
314:
313:
310:RNA expression
302:
301:
298:
297:
289:
285:
284:
276:
273:
268:
262:
261:
252:
245:
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98:
97:
54:
50:
49:
41:
33:
32:
28:
27:
24:
23:
15:
13:
10:
9:
6:
4:
3:
2:
1762:
1751:
1748:
1746:
1743:
1742:
1740:
1733:
1732:
1730:
1729:public domain
1726:
1715:
1711:
1706:
1701:
1696:
1691:
1687:
1683:
1680:(9): e12862.
1679:
1675:
1671:
1666:
1665:
1660:
1644:
1640:
1634:
1631:
1626:
1622:
1617:
1612:
1608:
1604:
1601:(2): 153–64.
1600:
1596:
1592:
1585:
1582:
1577:
1573:
1568:
1563:
1558:
1553:
1549:
1545:
1541:
1534:
1531:
1526:
1522:
1518:
1514:
1509:
1504:
1500:
1496:
1492:
1488:
1481:
1478:
1473:
1469:
1464:
1459:
1455:
1451:
1448:(1): 151–60.
1447:
1443:
1439:
1432:
1430:
1426:
1415:on 2018-07-30
1414:
1410:
1406:
1403:Yao, Daniel.
1399:
1396:
1385:
1381:
1375:
1372:
1367:
1363:
1358:
1353:
1349:
1345:
1342:(5): 615–24.
1341:
1337:
1333:
1326:
1324:
1322:
1318:
1307:
1303:
1297:
1295:
1293:
1289:
1284:
1280:
1274:
1271:
1266:
1262:
1256:
1253:
1249:
1245:
1240:
1238:
1236:
1232:
1228:
1224:
1219:
1217:
1215:
1211:
1204:
1200:
1196:
1192:
1188:
1184:
1179:
1177:
1169:
1167:
1165:
1161:
1157:
1153:
1152:mitochondrion
1149:
1145:
1141:
1137:
1133:
1129:
1125:
1121:
1117:
1113:
1109:
1105:
1101:
1097:
1093:
1089:
1081:
1079:
1077:
1073:
1069:
1065:
1061:
1057:
1053:
1049:
1045:
1044:chromosome 19
1041:
1037:
1030:
1028:
1026:
1022:
1019:
1018:mitochondrial
1015:
1011:
1007:
1004:. ECSIT is a
1003:
1000:
996:
992:
988:
976:
971:
967:
963:
960:
956:
949:
947:
944:
940:
936:
932:
929:
925:
921:
914:
912:
908:
904:
898:
894:
891:
885:
883:
879:
875:
871:
865:
861:
858:
854:
847:
845:
841:
837:
831:
827:
824:
818:
816:
812:
808:
804:
798:
794:
791:
789:RefSeq (mRNA)
787:
780:
779:
774:
770:
767:
761:
760:
755:
751:
748:
746:
742:
735:
734:
729:
725:
722:
716:
715:
710:
706:
703:
701:
697:
690:
689:
684:
680:
677:
671:
670:
665:
661:
658:
656:
652:
649:
646:
644:
641:
637:
634:
630:
626:
619:
615:
610:
604:
601:
599:
596:
594:
591:
589:
586:
585:
583:
580:
579:
573:
570:
568:
565:
563:
560:
558:
557:mitochondrion
555:
553:
550:
548:
545:
544:
542:
539:
538:
532:
529:
527:
524:
523:
521:
518:
517:
514:
513:Gene ontology
510:
506:
494:
489:
486:
484:
480:
472:
467:
456:
452:
448:
444:
440:
436:
432:
428:
424:
420:
419:
416:
412:
407:
404:
394:
390:
386:
382:
378:
375:right auricle
374:
370:
366:
362:
359:apex of heart
358:
357:
354:
350:
345:
342:
341:
338:
336:
332:
330:
329:
325:
324:
321:
319:
315:
311:
307:
303:
295:
290:
286:
282:
277:
267:
263:
256:
249:
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224:
220:
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211:
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202:
194:
189:
185:
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176:
166:
162:
155:
148:
142:
135:
131:
125:
121:
117:
112:
108:
103:
99:
95:
91:
87:
83:
79:
75:
71:
67:
63:
59:
51:
46:
39:
34:
29:
25:
20:
1722:
1721:
1677:
1673:
1647:. Retrieved
1642:
1633:
1598:
1594:
1584:
1547:
1543:
1533:
1493:(3): 501–7.
1490:
1486:
1480:
1445:
1441:
1417:. Retrieved
1413:the original
1408:
1398:
1387:. Retrieved
1383:
1374:
1339:
1335:
1309:. Retrieved
1305:
1282:
1273:
1264:
1255:
1189:, VISA, and
1173:
1170:Interactions
1085:
1076:mitochondria
1051:
1035:
1034:
998:
990:
986:
985:
907:NP_001240827
903:NP_001240826
900:
878:NP_001230133
874:NP_001135937
870:NP_001135936
867:
840:NM_001253898
836:NM_001253897
833:
815:NM_001243204
811:NM_001142465
807:NM_001142464
800:
776:
757:
731:
712:
686:
667:
647:
642:
429:right kidney
333:
326:
53:External IDs
1306:uniprot.org
1056:amino acids
567:nucleoplasm
292:21,996,734
279:21,983,542
271:9|9 A3
191:11,529,172
178:11,505,929
31:Identifiers
1739:Categories
1649:2018-08-25
1645:. EMBL-EBI
1508:2115/49795
1419:2018-07-27
1389:2018-07-30
1311:2018-07-27
1250:, May 2017
1229:, May 2017
1205:References
1185:, TRIM59,
1072:N-terminal
337:(ortholog)
74:HomoloGene
1160:complex I
1148:chaperone
1031:Structure
1025:complex I
1006:cytosolic
911:NP_036159
882:NP_057665
844:NM_012029
803:NM_016581
633:Orthologs
547:cytoplasm
82:GeneCards
1714:20877624
1674:PLOS ONE
1625:25228397
1576:25371197
1525:16613194
1517:22588174
1472:25355951
1366:17344420
1246:–
1225:–
1094:(TLRs),
1082:Function
959:Wikidata
612:Sources:
1705:2943476
1682:Bibcode
1616:6738808
1567:4271209
1463:4279226
1357:1820902
1248:Ensembl
1227:Ensembl
1191:NDUFAF1
1106:by the
995:protein
991:SITPEC,
745:UniProt
700:Ensembl
639:Species
618:QuickGO
572:cytosol
562:nucleus
312:pattern
170:19p13.2
70:1349469
38:Aliases
1712:
1702:
1623:
1613:
1574:
1564:
1523:
1515:
1470:
1460:
1364:
1354:
1195:MAP3K1
1114:, and
1098:, and
1064:lysine
1050:. The
945:search
943:PubMed
778:Q9QZH6
759:Q9BQ95
655:Entrez
483:BioGPS
62:608388
1521:S2CID
1199:SMAD4
1183:TRAF6
1136:RIG-I
1120:TRAF6
1116:IRF-7
1112:IRF-3
1104:NF-κB
1096:TGF-β
1060:NF-κB
1052:ECSIT
1048:exons
1040:p arm
1036:ECSIT
999:ECSIT
993:is a
688:26940
669:51295
648:Mouse
643:Human
614:Amigo
335:Mouse
328:Human
275:Start
210:Mouse
174:Start
107:Human
86:ECSIT
45:ECSIT
22:ECSIT
1710:PMID
1621:PMID
1572:PMID
1513:PMID
1468:PMID
1362:PMID
1197:and
1140:MDA5
1108:TLR4
1066:372
1002:gene
318:Bgee
266:Band
227:Chr.
165:Band
124:Chr.
78:8080
58:OMIM
1700:PMC
1690:doi
1611:PMC
1603:doi
1562:PMC
1552:doi
1548:289
1503:hdl
1495:doi
1491:422
1458:PMC
1450:doi
1352:PMC
1344:doi
1138:or
1100:BMP
1042:of
1027:).
491:n/a
288:End
187:End
90:OMA
66:MGI
1741::
1708:.
1698:.
1688:.
1676:.
1672:.
1641:.
1619:.
1609:.
1597:.
1593:.
1570:.
1560:.
1546:.
1542:.
1519:.
1511:.
1501:.
1489:.
1466:.
1456:.
1446:26
1444:.
1440:.
1428:^
1407:.
1382:.
1360:.
1350:.
1340:21
1338:.
1334:.
1320:^
1304:.
1291:^
1281:.
1263:.
1234:^
1213:^
1166:.
1012:,
616:/
294:bp
281:bp
193:bp
180:bp
88:;
84::
80:;
76::
72:;
68::
64:;
60::
1731:.
1716:.
1692::
1684::
1678:5
1652:.
1627:.
1605::
1599:7
1578:.
1554::
1527:.
1505::
1497::
1474:.
1452::
1422:.
1392:.
1368:.
1346::
1314:.
1285:.
1267:.
1158:(
1134:(
1023:(
212:)
109:)
92::
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