584:
most studied and intact among the family of ErbB proteins, Which forms functional intracellular tyrosine kinases. ErbB2 has no known binding ligand and absent of an active kinase domain in ErbB3 make this duo preferable to form heterodimers & share each other's active domains to activate transphosphorylation of the tyrosine kinases. The specific tyrosine molecules mainly trans or auto-phosphorylated are at the site Y992, Y1045, Y1068, Y1148, Y1173 in the tail region of the ErbB monomer. For the activation of kinase domain in the ErbB dimer, asymmetric kinase domain dimer of the two monomers is required with the intact asymmetric (N-C lobe) interface at the site of adjoining monomers. Activation of the tyrosine kinase domain leads to the activation of the whole range of downstream signaling pathways like PLCÎł, ERK 1/2, p38
676:
proliferation of tumor cells. Trastuzumab targets tumor cells and causes apoptosis through the immune system by promoting antibody-dependent cellular cytotoxicity. Two thirds of women respond to trastuzumab. Although herceptin works well in most breast cancer cases, it has not been yet elucidated as to why some HER2-positive breast cancers don't respond well. Research suggests that a low FISH test ratio in estrogen receptor positive breast cancers are less likely to respond to this drug. ErbB expression as also been linked to cutaneous
Squamous Cell Carcinoma (cSCC) development, where the over-expression of these receptors has been found in cSCC tumors. Based on a study conducted by Cañueto et al. (2017), ErbB over-expression in tumors was linked to lymph node progression and metastasis stage progression in cSCC.
219:-rich region, and these CR domains contain disulfide modules in their structure as 8 disulfide modules in CR1 domain, whereas 7 modules in CR2 domain. These subdomains are shown in blue (L1), green (CR1), yellow (L2), and red (CR2) in the figure below. These subdomains are also referred to as domains I-IV, respectively. The intracellular/cytoplasmic region of the ErbB receptor consists mainly of three subdomains: A juxtamembrane with approximately 40 residues, a kinase domain containing approximately 260 residues and a C-terminal domain of 220-350 amino acid residues that become activated via phosphorylation of its tyrosine residues that mediates interactions of other ErbB proteins and downstream signaling molecules.
288:
7573:
664:, and lapatinib are used to inhibit it. Cetuximab is a chimeric human: murin immunoglobulin G1 mAb that binds EGFR with high affinity and promotes EGFR internalization. It has recently been shown that acquired resistance to cetuximab and gefitinib can be linked to hyperactivity of ErbB-3. This is linked to an acquired overexpression of
583:
in a kinase domain, that activates the further process of transphosphorylation of the specific tyrosine kinases in the kinase domain of ErbB's intracellular part. It is a complex process due to the domain specificity and nature of the members of ErbB family. Notably, the ErbB1 and ErbB4 are the two
123:
ErbB protein family signaling is important for development. For example, ErbB-2 and ErbB-4 knockout mice die at midgestation leads to deficient cardiac function associated with a lack of myocardial ventricular trabeculation and display abnormal development of the peripheral nervous system. In ErbB-3
675:
ErbB2 overexpression can occur in breast, ovarian, bladder, non-small-cell lung carcinoma, as well as several other tumor types. Trastuzumab or
Herceptin inhibits downstream signal cascades by selectively binding to the extracellular domain of ErbB-2 receptors to inhibit it. This leads to decreased
599:
conformation in which a 10-amino-acid-long dimerization arm is unable to mediate monomer-monomer interactions. In contrast, in ligand-bound ErbB-1 and unliganded ErbB-2, the dimerization arm becomes untethered and exposed at the receptor surface, making monomer-monomer interactions and dimerisation
616:
amino acids can occur within the cytoplasmic domain of each ErbB. At least 10 specific tyrosines, 7 serines, and 2 threonines have been identified within the cytoplasmic domain of ErbB-1, that may become phosphorylated and in some cases de-phosphorylated (e.g., Tyr 992) upon receptor dimerization.
2101:
Cañueto, J., Cardeñoso, E., GarcĂa, J. L., Santos-Briz, Ă., Castellanos-MartĂn, A., FernĂĄndez-LĂłpez, E., Blanco GĂłmez, A., PĂ©rez-Losada, J., & RomĂĄn-Curto, C. (2017). Epidermal growth factor receptor expression is associated with poor outcome in cutaneous squamous cell carcinoma. The
British
291:
A superposition of similar interfaces observed in crystal structures of the ERBB kinases, including EGFR, ERBB2 (HER2) and ERBB4 (HER4). The protein chains are colored from blue to red from N to C terminus. The kinase at the top of each dimer (as shown) activates the kinase at the bottom of each
640:
The PI3K/Akt pathway is dysregulated in many human tumors because of mutations altering proteins in the pathway. In relation to breast tumors, somatic activating mutations in Akt and the p110α subunit of the PI3K have been detected in 3â5% and 20â25% of primary breast tumors, respectively. Many
636:
Genetic Ras mutations are infrequent in breast cancer but Ras may be pathologically activated in breast cancer by overexpression of ErbB receptors. Activation of the receptor tyrosine kinases generates a signaling cascade where the Ras GTPase proteins are activated to a GTP-bound state. The RAS
672:. Panitumumab is a human mAb with high EGFR affinity that blocks ligand-binding to induce EGFR internalization. Panitumumab efficacy has been tested in a variety of advanced cancer patients, including renal carcinomas and metastatic colorectal cancer in clinical trials.
104:). The gene symbol, ErbB, is derived from the name of a viral oncogene to which these receptors are homologous: erythroblastic leukemia viral oncogene. Insufficient ErbB signaling in humans is associated with the development of
246:
1732:"Dynamic profiling of the post-translational modifications and interaction partners of epidermal growth factor receptor signaling after stimulation by epidermal growth factor using Extended Range Proteomic Analysis (ERPA)"
2072:
Nishimura R, Okumura Y, Arima N. (2008). âTrastuzumab monotherapy versus combination therapy for treating recurrent breast cancer: time to progression and survivalâ. Breast Cancer, 15: 57-64 doi: 10.1007/s12282-007-0014-z
791:
Chan R, Hardy W, Laing M, Muller W. (2017). âThe
Catalytic Activity of the ErbB-2 Receptor Tyrosine Kinase Is Essential for Embryonic Developmentâ. Molecular Cell Biology. 22: 1073-1078 doi: 10.1128/MCB.22.4.10731078.2002
1995:
Engelman JA, Zejnullahu K, Mitsudomi T, Song Y, Hyland C, Park JO, Lindeman N, Gale CM, Zhao X, Christensen J, Kosaka T, Holmes AJ, Rogers AM, Cappuzzo F, Mok T, Lee C, Johnson BE, Cantley LC, JĂ€nne PA (May 2007).
1900:
Hollestelle A, Elstrodt F, Nagel J, Kallemeign W, Schutte M. (2007). âPhosphatidylinositol-3-OH Kinase or RAS Pathway
Mutations in Human Breast Cancer Cell Linesâ. Molecular Cancer Research, 5: 195-201 doi:
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808:
Burgess, Antony W.; Cho, Hyun-Soo; Eigenbrot, Charles; Ferguson, Kathryn M.; Garrett, Thomas P. J.; Leahy, Daniel J.; Lemmon, Mark A.; Sliwkowski, Mark X.; Ward, Colin W. (2003-09-01).
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breast tumors also have lower levels of PTEN, which is a lipid phosphatase that dephosphorylates phosphatidylinositol (3,4,5)-trisphosphate, thereby reversing the action of PI3K.
1965:
Appert A, Hubert P, Cremel G, Bennasroune A. (2015). âRole of ErbB Receptors in Cancer Cell
Migration and Invasionâ. Front Pharmacology, 6: 283 doi: 10.3389/fphar.2015.00283
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domain containing up to approximately 540 residues. The extracellular region of each family member is made up of 4 subdomains, L1, CR1, L2, and CR2, where "L" signifies a
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7514:
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Although a number of potential phosphorylation sites exist, upon dimerization only one or much more rarely two of these sites are phosphorylated at any one time.
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2118:
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maturation leads to degeneration of motor and sensory neurons. Excessive ErbB signaling is associated with the development of a wide variety of types of solid
7170:
6318:
3074:
5935:
4625:
4198:
3359:
2619:
5993:
3268:
2463:
2458:
579:
The dimerization occurs after ligand bind to the extracellular domain of the ErbB monomers and monomer-monomer interaction establishes activating the
195:
All four ErbB receptor family members are nearly same in the structure having single-chain of modular glycoproteins. This structure is made up of an
6855:
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4071:
3023:
6150:
3497:
3286:
2810:
5135:
4818:
3812:
1022:
Ward C.W.; Lawrence M.C.; et al. (2007). "The insulin and EGF receptor structures: new insights into ligand-induced receptor activation".
7533:
7483:
7454:
7401:
5888:
5755:
3454:
3324:
3193:
2968:
7212:
7208:
7204:
7200:
4753:
4737:
3482:
3069:
3008:
5481:
5400:
5267:
5184:
3850:
3841:
3541:
3536:
3531:
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3123:
3118:
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receptor mutant mice, they have less severe defects in the heart and thus are able to survive longer throughout embryogenesis. Lack of
7593:
7196:
3735:
3726:
1517:
Seshacharyulu, Parthasarathy; Ponnusamy, Moorthy P.; Haridas, Dhanya; Jain, Maneesh; Ganti, Apar K.; Batra, Surinder K. (2012-01-01).
6885:
6004:
5564:
5175:
4348:
3517:
3103:
1306:"Crystal structure of a truncated epidermal growth factor receptor extracellular domain bound to transforming growth factor alpha"
4833:
4777:
4768:
3420:
3212:
2961:
2315:
157:
85:
1393:
Akhtar, Saghir; Chandrasekhar, Bindu; Attur, Sreeja; Dhaunsi, Gursev S.; Yousif, Mariam H. M.; Benter, Ibrahim F. (2015-01-01).
7407:
284:
The ability ('+') or inability ('-') of each growth factor to activate each of the ErbB receptors is shown in the table below:
223:
975:"Crystal structure of a truncated epidermal growth factor receptor extracellular domain bound to transforming growth factor α"
7494:
7470:
6610:
6166:
6029:
3352:
3256:
2177:
4504:
1057:
Qiu, C; Tarrant, M; Choi, S; Sathyamurthy, A; Bose, R; Banjade, S; Pal, A; Bommann, W; Lemmon, M; Cole, P; Leahy, D (2008).
1574:
Henriksen, Lasse; Grandal, Michael Vibo; Knudsen, Stine Louise Jeppe; van Deurs, Bo; GrĂžvdal, Lene MelsĂŠther (2013-01-01).
7460:
3565:
3235:
7563:
644:
EGFR has been found to be overexpressed in many cancers such as gliomas and non-small-cell lung carcinoma. Drugs such as
7504:
5900:
5782:
5772:
3996:
3928:
3919:
3264:
3138:
3004:
1820:
Jorissen RN, Walker F, et al. (2003). "Epidermal growth factor receptor: mechanisms of activation and signalling".
6850:
4302:
4293:
4229:
4057:
2429:
6875:
4273:
1395:"Transactivation of ErbB Family of Receptor Tyrosine Kinases Is Inhibited by Angiotensin-(1-7) via Its Mas Receptor"
7489:
5315:
3740:
3278:
3031:
2443:
2351:
2267:
2238:
6870:
4489:
692:
Bublil EM, Yarden Y (April 2007). "The EGF receptor family: spearheading a merger of signaling and therapeutics".
7397:
4605:
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4579:
4566:
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4540:
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3345:
2839:
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2477:
105:
4499:
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5416:
5283:
5200:
4453:
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3091:
3062:
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2996:
2296:
2182:
81:
5015:
2082:
637:
pathway can couple with the mitogen-activated protein kinase pathway or a number of other possible effectors.
600:
possible. The consequence of ectodomain dimerization is the positioning of two cytoplasmic domains such that
7181:
4928:
4803:
4401:
4114:
4105:
3013:
2984:
2522:
2200:
1576:"Internalization mechanisms of the epidermal growth factor receptor after activation with different ligands"
348:
315:
6860:
625:
Phosphorylated tyrosine residues act as binding sites for intracellular signal activators such as Ras. The
7465:
7081:
6985:
6845:
6605:
6024:
5010:
4648:
3403:
2988:
2899:
2708:
113:
7539:
5736:
5380:
5020:
4659:
4422:
4341:
4066:
3750:
2398:
2209:
2153:
2141:
669:
630:
589:
308:
274:
116:, while excessive ErbB signaling is associated with the development of a wide variety of types of solid
4494:
7603:
7479:
6865:
5797:
5746:
3319:
3188:
2824:
2009:
1587:
1406:
1258:
1119:
743:
267:
6615:
4690:
6620:
6034:
5731:
4923:
4458:
3764:
3045:
3040:
2282:
63:
5656:
7598:
7238:
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7096:
7050:
6995:
6730:
6670:
6298:
5671:
5601:
5160:
4758:
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4651:
4391:
4148:
4138:
4129:
3957:
3948:
3035:
2337:
2035:
1674:
1353:
Linggi B, Carpenter G (December 2006). "ErbB receptors: new insights on mechanisms and biology".
1335:
1145:
1004:
955:
918:"An allosteric mechanism for activation of the kinase domain of epidermal growth factor receptor"
893:
769:
109:
7233:
7111:
7010:
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6685:
6485:
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5492:
5411:
5350:
5278:
5257:
5242:
5195:
4848:
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595:
When not bound to a ligand, the extracellular regions of ErbB1, ErbB3, and ErbB4 are found in a
7333:
7191:
7126:
7106:
7025:
7005:
6720:
6700:
6680:
6323:
5651:
5375:
4908:
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7000:
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6771:
6735:
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6107:
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6054:
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4182:
2027:
1998:"MET amplification leads to gefitinib resistance in lung cancer by activating ERBB3 signaling"
1933:
1878:
1837:
1802:
1753:
1709:
1666:
1658:
1623:
1605:
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1370:
1327:
1304:
Garrett TP, McKern NM, Lou M, Elleman TC, Adams TE, Lovrecz GO, et al. (September 2002).
1286:
1227:
1186:
1165:"EGF activates its receptor by removing interactions that autoinhibit ectodomain dimerization"
1137:
1088:
1039:
996:
947:
939:
885:
839:
831:
761:
709:
7116:
7015:
6910:
6814:
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6759:
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6140:
6130:
6082:
6064:
5827:
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239:
235:
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227:
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4406:
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2537:
2017:
1925:
1868:
1829:
1792:
1784:
1743:
1701:
1692:
Linggi, B.; Carpenter, G. (2006). "ErbB receptors: new insights on mechanisms and biology".
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dimer (Zhang et al., Cell v. 125, pp. 1137â1149, 2008). The cluster was identified with the
287:
5867:
3706:
1247:"The extracellular region of ErbB4 adopts a tethered conformation in the absence of ligand"
222:
The figure below shows the tridimensional structure of the ErbB family proteins, using the
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4381:
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3716:
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3691:
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3372:
2937:
601:
580:
208:
187:
v-ErbBs are homologous to EGFR, but lack sequences within the ligand binding ectodomain.
2013:
1591:
1410:
1262:
1123:
747:
207:-spanning region containing approximately 23 residues, and an intracellular cytoplasmic
7577:
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7392:
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6935:
6930:
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4675:
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2110:
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1281:
1246:
1083:
1058:
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Yarden, Y.; Sliwkowski, M. X. (2001-02-01). "Untangling the ErbB signalling network".
1322:
1305:
1222:
1205:
1181:
1164:
991:
974:
916:
Zhang, Xuewu; Gureasko, Jodi; Shen, Kui; Cole, Philip A.; Kuriyan, John (2006-06-16).
880:
863:
826:
809:
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959:
773:
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7141:
7040:
6895:
6715:
6650:
6565:
6069:
5872:
5711:
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5626:
5576:
5390:
5144:
5125:
5104:
5075:
4798:
4793:
4376:
4158:
3869:
3860:
3604:
3144:
2653:
2413:
1678:
897:
495:
432:
411:
125:
1916:
Hynes, N; MacDonald, G (2009). "ErbB receptors and signaling pathways in cancer".
1467:"Molecular Mechanisms that Regulate Epidermal Growth Factor Receptor Inactivation"
810:"An open-and-shut case? Recent insights into the activation of EGF/ErbB receptors"
633:, both of which lead to increased cell proliferation and inhibition of apoptosis.
1873:
1856:
1600:
1534:
1419:
1206:"Insights into ErbB signaling from the structure of the ErbB2-pertuzumab complex"
88:(EGFR), its first discovered member. In humans, the family includes Her1 (EGFR,
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1748:
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1035:
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864:"Ligand-Induced, Receptor-Mediated Dimerization and Activation of EGF Receptor"
136:, and their excessive signaling may be critical factors in the development and
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region or ectodomain or ligand binding region that contains approximately 620
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1108:"Structure of the extracellular region of HER3 reveals an interdomain tether"
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732:"Structure of the extracellular region of HER3 reveals an interdomain tether"
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1976:"EGFR Inhibitors: Toxicities and Strategies for Effective Management"
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133:
2103:
2083:"Why Do Some HER2-Positive Breast Cancers Not Respond to Herceptin?"
245:
258:
The four members of the ErbB protein family are capable of forming
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2332:
2325:
2253:
665:
297:
286:
244:
181:
175:
141:
129:
117:
101:
97:
93:
89:
1059:"Mechanism of Activation and Inhibition of the HER4/ErbB4 Kinase"
6915:
5521:
5517:
5513:
5509:
5505:
5501:
5436:
5432:
5428:
5424:
5420:
5323:
5319:
5311:
5307:
5303:
5299:
5295:
5291:
5287:
5228:
5224:
5220:
5216:
5212:
5208:
5204:
5156:
5152:
5148:
5114:
5079:
5060:
4213:
4143:
4090:
4081:
4042:
4033:
4023:
3904:
3895:
3885:
3831:
3822:
3807:
3798:
3788:
3783:
3759:
3560:
3240:
3230:
2912:
2907:
2872:
2794:
2571:
1773:"Phosphotyrosine interactome of the ErbB-receptor kinase family"
164:
4621:
4330:
3994:
3388:
3341:
2957:
2114:
4244:
4239:
4234:
4208:
2856:
2713:
2703:
2492:
1861:
International
Journal of Radiation Oncology, Biology, Physics
668:, which phosphorylates ErbB-3, which in turn activates the
629:
is a major signalling route for the ErbB family, as is the
4326:
1465:
Ceresa, Brian P.; Vanlandingham, Phillip A. (2008-01-01).
1519:"Targeting the EGFR signaling pathway in cancer therapy"
7515:
Pituitary adenylate cyclase-activating peptide (PACAP)
7561:
1857:"Review of epidermal growth factor receptor biology"
7382:
7169:
7064:
6833:
6573:
6564:
6544:
6458:
6435:
6404:
6373:
6342:
6306:
6297:
6149:
5992:
5925:
5887:
5754:
5745:
5563:
5540:
5480:
5399:
5266:
5183:
5174:
5113:
5059:
4972:
4776:
4767:
4736:
4658:
4513:
4477:
4446:
4415:
4364:
4292:
4253:
4222:
4191:
4157:
4128:
4104:
4080:
4056:
4032:
4008:
3966:
3947:
3918:
3894:
3878:
3859:
3840:
3821:
3797:
3773:
3749:
3725:
3636:
3603:
3579:
3550:
3516:
3473:
3444:
3411:
3402:
3312:
3277:
3255:
3090:
3022:
2995:
2925:
2898:
2889:
2865:
2832:
2823:
2803:
2782:
2773:
2748:
2735:
2696:
2670:
2661:
2652:
2628:
2612:
2605:
2585:
2559:
2550:
2530:
2521:
2501:
2485:
2476:
2451:
2442:
2422:
2406:
2397:
2388:
2359:
2350:
2304:
2295:
2275:
2266:
2246:
2237:
2217:
2208:
2199:
2170:
2161:
2152:
62:
50:
42:
37:
32:
7461:Glucose-6-phosphate isomerase (GPI; PGI, PHI, AMF)
6319:Glial cell line-derived neurotrophic factor (GDNF)
5972:Cleavage products/derivatives with unknown target:
249:Comparison of ErbB extracellular domain structures
1961:
1959:
1957:
1955:
1953:
1951:
1949:
1947:
7495:Macrophage-stimulating protein (MSP; HLP, HGFLP)
5136:Heparin-binding EGF-like growth factor (HB-EGF)
4819:Heparin-binding EGF-like growth factor (HB-EGF)
152:The ErbB protein family consists of 4 members
7547:Additional growth factor receptor modulators:
4633:
4342:
3353:
2969:
2126:
8:
5901:Insulin-like growth factor-2 (somatomedin A)
5783:Insulin-like growth factor-2 (somatomedin A)
5773:Insulin-like growth factor-1 (somatomedin C)
1163:Ferguson KM, Berger MB, et al. (2003).
787:
785:
783:
132:. ErbB-1 and ErbB-2 are found in many human
2102:journal of dermatology, 176(5), 1279â1287.
1204:Franklin MC, Carey KD, et al. (2004).
973:Garrett TP, McKern NM, et al. (2002).
6570:
6303:
5751:
5180:
4773:
4640:
4626:
4618:
4349:
4335:
4327:
4005:
3991:
3408:
3399:
3385:
3360:
3346:
3338:
3096:
2976:
2962:
2954:
2895:
2829:
2779:
2745:
2667:
2658:
2609:
2556:
2527:
2482:
2448:
2403:
2394:
2356:
2301:
2272:
2243:
2214:
2205:
2167:
2158:
2133:
2119:
2111:
2021:
1872:
1796:
1747:
1617:
1599:
1550:
1490:
1436:
1418:
1321:
1280:
1270:
1245:Bouyain S, Longo PA, et al. (2005).
1221:
1180:
1131:
1082:
990:
933:
879:
825:
755:
270:upon activation by a subset of potential
7505:Migration-stimulating factor (MSF; PRG4)
3024:Receptor protein serine/threonine kinase
303:
7568:
4834:Transforming growth factor alpha (TGFα)
2054:"Cancer therapies addressing HGF/c-Met"
1911:
1909:
1907:
684:
7408:Connective tissue growth factor (CTGF)
1896:
1894:
1892:
1725:
1723:
29:
7471:Hepatoma-derived growth factor (HDGF)
1643:Nature Reviews Molecular Cell Biology
1523:Expert Opinion on Therapeutic Targets
1512:
1510:
1460:
1458:
1456:
1388:
1386:
1384:
911:
909:
907:
857:
855:
853:
725:
723:
7:
803:
801:
799:
797:
1771:Schulze WX, Deng L, Mann M (2005).
1730:Wu SL, Kim J, et al. (2006).
296:database. The image was made with
25:
2104:https://doi.org/10.1111/bjd.14936
80:family of proteins contains four
7571:
7490:Leukemia inhibitory factor (LIF)
730:Cho HS, Leahy DJ (August 2002).
158:epidermal growth factor receptor
86:epidermal growth factor receptor
6658:Negative allosteric modulators:
1918:Current Opinion in Cell Biology
694:Current Opinion in Cell Biology
215:-rich repeat domain and "CR" a
6976:Gossypetin (3,5,7,8,3',4'-HHF)
6167:Platelet-derived growth factor
3287:Platelet-derived growth factor
3257:Tumor necrosis factor receptor
281:that activate ErbB receptors.
84:, structurally related to the
1:
7182:Placental growth factor (PGF)
3997:Non-receptor tyrosine kinases
1901:10.1158/1541-7786.MCR-06-0263
1834:10.1016/S0014-4827(02)00098-8
1323:10.1016/S0092-8674(02)00940-6
1223:10.1016/S1535-6108(04)00083-2
1182:10.1016/S1097-2765(03)00047-9
992:10.1016/S0092-8674(02)00940-6
881:10.1016/s0092-8674(02)00966-2
862:Schlessinger, Joseph (2002).
827:10.1016/s1097-2765(03)00350-2
7466:Glia maturation factor (GMF)
5975:Glypromate (GPE, (1-3)IGF-1)
3325:Insulin-like growth factor 2
3194:Insulin-like growth factor 1
2390:Intracellular signaling P+Ps
1874:10.1016/j.ijrobp.2003.11.041
1601:10.1371/journal.pone.0058148
1535:10.1517/14728222.2011.648617
1420:10.1371/journal.pone.0141657
266:, and possibly higher-order
3009:Ciliary neurotrophic factor
1471:Clinical Medicine: Oncology
7620:
7398:Colony-stimulating factors
7390:Additional growth factors:
3070:Bone morphogenetic protein
2444:TGF beta signaling pathway
2352:JAK-STAT signaling pathway
2268:TGF beta signaling pathway
2239:Hedgehog signaling pathway
1749:10.1074/mcp.M600105-MCP200
1251:Proc. Natl. Acad. Sci. USA
1036:10.1016/j.tibs.2007.01.001
935:10.1016/j.cell.2006.05.013
254:ErbB and Kinase activation
106:neurodegenerative diseases
7594:Tyrosine kinase receptors
6746:SNA-120 (pegylated K252a)
5918:(against IGF-1 and IGF-2)
5880:(against IGF-1 and IGF-2)
4505:MichaelisâMenten kinetics
4004:
3990:
3398:
3391:Receptor tyrosine kinases
3384:
3221:
3204:
3184:
3171:
3134:
3099:
2478:Akt/PKB signaling pathway
1930:10.1016/j.ceb.2008.12.010
1706:10.1016/j.tcb.2006.10.008
1367:10.1016/j.tcb.2006.10.008
1106:Cho HS; Leahy DJ (2002).
1075:10.1016/j.str.2007.12.016
706:10.1016/j.ceb.2007.02.008
313:
82:receptor tyrosine kinases
5582:Hepatocyte growth factor
5141:Neuregulins (heregulins)
5072:Neuregulins (heregulins)
5016:Trastuzumab duocarmazine
4729:(against angiopoietin 2)
4723:(against angiopoietin 3)
4397:Diffusion-limited enzyme
3176:Hepatocyte growth factor
3104:Fibroblast growth factor
3092:Receptor tyrosine kinase
2997:Type I cytokine receptor
2297:Receptor tyrosine kinase
592:and more with the cell.
4929:Depatuxizumab mafodotin
3404:Growth factor receptors
3213:Epidermal growth factor
2989:growth factor receptors
2523:Hippo signaling pathway
2023:10.1126/science.1141478
1272:10.1073/pnas.0507591102
1133:10.1126/science.1074611
757:10.1126/science.1074611
7552:(neurotrophin mixture)
7540:Wnt signaling proteins
7221:Allosteric modulators:
6941:Norwogonin (5,7,8-THF)
5161:5 (tomoregulin, TMEFF)
5011:Trastuzumab deruxtecan
4649:Growth factor receptor
2538:Neurofibromin 2/Merlin
2142:Tumor suppressor genes
1355:Trends in Cell Biology
301:
250:
7480:T-cell growth factors
5737:Telisotuzumab vedotin
5021:Trastuzumab emtansine
4490:EadieâHofstee diagram
4423:Allosteric regulation
2399:Wnt signaling pathway
2210:Wnt signaling pathway
1783:(2005.0008): E1âE13.
1736:Mol. Cell. Proteomics
290:
248:
6065:EVT-901 (SAR-127963)
5798:Mecasermin rinfabate
4500:LineweaverâBurk plot
3475:PDGF receptor family
3265:Nerve growth factors
3139:Nerve growth factors
3005:Nerve growth factors
2825:Transcription factor
627:Ras-Raf-MAPK pathway
602:transphosphorylation
3879:ROS receptor family
3413:EGF receptor family
2900:Apoptosis inhibitor
2283:TGF beta receptor 2
2014:2007Sci...316.1039E
1855:Herbst, RS (2004).
1592:2013PLoSO...858148H
1411:2015PLoSO..1041657A
1263:2005PNAS..10215024B
1257:(42): 15024â15029.
1124:2002Sci...297.1330C
1118:(5585): 1330â1333.
1024:Trends Biochem. Sci
748:2002Sci...297.1330C
180:ErbB-4, also named
174:ErbB-3, also named
163:ErbB-2, also named
156:ErbB-1, also named
114:Alzheimer's disease
33:EGF receptor family
7231:Kinase inhibitors:
7094:Kinase inhibitors:
6993:Kinase inhibitors:
6668:Kinase inhibitors:
6483:Kinase inhibitors:
6443:Kinase inhibitors:
6424:Kinase inhibitors:
6393:Kinase inhibitors:
6362:Kinase inhibitors:
6331:Kinase inhibitors:
6191:Kinase inhibitors:
5805:Kinase inhibitors:
5599:Kinase inhibitors:
5388:Kinase inhibitors:
5381:Aprutumab ixadotin
5028:Kinase inhibitors:
4841:Kinase inhibitors:
4698:Kinase inhibitors:
4459:Enzyme superfamily
4392:Enzyme promiscuity
1789:10.1038/msb4100012
302:
251:
110:multiple sclerosis
27:Family of proteins
7559:
7558:
7165:
7164:
6926:N-Acetylserotonin
6825:ReN-1820 (TrkAd5)
6454:
6453:
5988:
5987:
5933:Binding proteins:
5592:Dihexa (PNB-0408)
5559:
5558:
5170:
5169:
5084:6 (neuroglycan C)
4804:EGF (urogastrone)
4782:
4615:
4614:
4324:
4323:
4320:
4319:
4316:
4315:
3986:
3985:
3982:
3981:
3632:
3631:
3335:
3334:
3251:
3250:
2951:
2950:
2921:
2920:
2885:
2884:
2881:
2880:
2819:
2818:
2769:
2768:
2731:
2730:
2648:
2647:
2644:
2643:
2601:
2600:
2546:
2545:
2517:
2516:
2472:
2471:
2438:
2437:
2384:
2383:
2380:
2379:
2346:
2345:
2291:
2290:
2262:
2261:
2233:
2232:
2195:
2194:
2191:
2190:
2008:(5827): 1039â43.
631:PI3-K/AKT pathway
577:
576:
74:
73:
16:(Redirected from
7611:
7576:
7575:
7567:
7371:Decoy receptors:
7344:Alacizumab pegol
6822:Decoy receptors:
6571:
6476:Stem cell factor
6417:Persephin (PSPN)
6355:Neurturin (NRTN)
6304:
6141:LEVI-04 (p75-Fc)
6138:Decoy receptors:
5752:
5181:
4780:
4774:
4642:
4635:
4628:
4619:
4495:HanesâWoolf plot
4438:Enzyme activator
4433:Enzyme inhibitor
4407:Enzyme catalysis
4351:
4344:
4337:
4328:
4006:
3992:
3446:Insulin receptor
3409:
3400:
3386:
3373:tyrosine kinases
3362:
3355:
3348:
3339:
3304:Stem cell factor
3269:Low affinity/p75
3097:
2978:
2971:
2964:
2955:
2896:
2830:
2780:
2775:Ubiquitin ligase
2746:
2668:
2659:
2610:
2557:
2552:MAPK/ERK pathway
2528:
2483:
2449:
2404:
2395:
2357:
2302:
2273:
2244:
2215:
2206:
2168:
2159:
2135:
2128:
2121:
2112:
2106:
2099:
2093:
2092:
2090:
2089:
2079:
2073:
2070:
2064:
2063:
2061:
2060:
2050:
2044:
2043:
2025:
1992:
1986:
1985:
1983:
1982:
1972:
1966:
1963:
1942:
1941:
1913:
1902:
1898:
1887:
1886:
1876:
1852:
1846:
1845:
1817:
1811:
1810:
1800:
1768:
1762:
1761:
1751:
1742:(9): 1610â1627.
1727:
1718:
1717:
1694:Trends Cell Biol
1689:
1683:
1682:
1655:10.1038/35052073
1638:
1632:
1631:
1621:
1603:
1571:
1565:
1564:
1554:
1514:
1505:
1504:
1494:
1483:10.4137/cmo.s498
1462:
1451:
1450:
1440:
1422:
1405:(11): e0141657.
1390:
1379:
1378:
1350:
1344:
1343:
1325:
1301:
1295:
1294:
1284:
1274:
1242:
1236:
1235:
1225:
1201:
1195:
1194:
1184:
1160:
1154:
1153:
1135:
1103:
1097:
1096:
1086:
1054:
1048:
1047:
1019:
1013:
1012:
994:
970:
964:
963:
937:
928:(6): 1137â1149.
913:
902:
901:
883:
859:
848:
847:
829:
805:
792:
789:
778:
777:
759:
742:(5585): 1330â3.
727:
718:
717:
689:
304:
30:
21:
7619:
7618:
7614:
7613:
7612:
7610:
7609:
7608:
7584:
7583:
7582:
7570:
7562:
7560:
7555:
7500:Midkine (NEGF2)
7378:
7161:
7060:
6829:
6767:ABT-110 (PG110)
6560:
6540:
6450:
6431:
6400:
6369:
6338:
6293:
6145:
6083:ABT-110 (PG110)
5984:
5921:
5883:
5741:
5555:
5536:
5476:
5473:(against FGF23)
5395:
5262:
5166:
5109:
5055:
4968:
4779:
4763:
4732:
4654:
4646:
4616:
4611:
4523:Oxidoreductases
4509:
4485:Enzyme kinetics
4473:
4469:List of enzymes
4442:
4411:
4382:Catalytic triad
4360:
4355:
4325:
4312:
4288:
4249:
4218:
4187:
4153:
4124:
4100:
4076:
4052:
4028:
4000:
3978:
3962:
3943:
3914:
3890:
3874:
3855:
3836:
3817:
3793:
3769:
3745:
3721:
3628:
3599:
3575:
3546:
3512:
3469:
3440:
3394:
3380:
3369:Protein kinases
3366:
3336:
3331:
3313:Other/ungrouped
3308:
3273:
3247:
3217:
3200:
3180:
3167:
3130:
3086:
3018:
2991:
2982:
2952:
2947:
2926:Other/ungrouped
2917:
2877:
2861:
2815:
2799:
2765:
2727:
2692:
2640:
2624:
2597:
2593:Neurofibromin 1
2581:
2542:
2513:
2497:
2468:
2434:
2418:
2376:
2342:
2287:
2258:
2229:
2187:
2148:
2139:
2109:
2100:
2096:
2087:
2085:
2081:
2080:
2076:
2071:
2067:
2058:
2056:
2052:
2051:
2047:
1994:
1993:
1989:
1980:
1978:
1974:
1973:
1969:
1964:
1945:
1915:
1914:
1905:
1899:
1890:
1854:
1853:
1849:
1819:
1818:
1814:
1777:Mol. Syst. Biol
1770:
1769:
1765:
1729:
1728:
1721:
1700:(12): 649â656.
1691:
1690:
1686:
1640:
1639:
1635:
1573:
1572:
1568:
1516:
1515:
1508:
1464:
1463:
1454:
1392:
1391:
1382:
1352:
1351:
1347:
1303:
1302:
1298:
1244:
1243:
1239:
1203:
1202:
1198:
1162:
1161:
1157:
1105:
1104:
1100:
1056:
1055:
1051:
1021:
1020:
1016:
972:
971:
967:
915:
914:
905:
861:
860:
851:
807:
806:
795:
790:
781:
729:
728:
721:
691:
690:
686:
682:
623:
581:activation loop
277:. There are 11
256:
209:tyrosine kinase
193:
150:
28:
23:
22:
15:
12:
11:
5:
7617:
7615:
7607:
7606:
7601:
7596:
7586:
7585:
7581:
7580:
7557:
7556:
7554:
7553:
7543:
7542:
7537:
7530:Thrombopoietin
7527:
7522:
7517:
7512:
7507:
7502:
7497:
7492:
7487:
7473:
7468:
7463:
7458:
7451:Erythropoietin
7448:
7410:
7405:
7395:
7393:Adrenomedullin
7386:
7384:
7380:
7379:
7377:
7376:
7367:
7366:
7361:
7356:
7351:
7346:
7337:
7336:
7331:
7326:
7321:
7316:
7311:
7306:
7301:
7296:
7291:
7286:
7281:
7276:
7271:
7266:
7261:
7256:
7251:
7246:
7241:
7236:
7227:
7226:
7217:
7216:
7194:
7189:
7184:
7175:
7173:
7167:
7166:
7163:
7162:
7160:
7159:
7154:
7149:
7144:
7139:
7134:
7129:
7124:
7119:
7114:
7109:
7104:
7099:
7090:
7089:
7084:
7079:
7070:
7068:
7062:
7061:
7059:
7058:
7053:
7048:
7043:
7038:
7033:
7028:
7023:
7018:
7013:
7008:
7003:
6998:
6989:
6988:
6979:
6978:
6973:
6968:
6959:
6958:
6953:
6948:
6943:
6938:
6933:
6928:
6923:
6918:
6913:
6908:
6903:
6898:
6893:
6888:
6883:
6878:
6873:
6868:
6863:
6858:
6856:4'-DMA-7,8-DHF
6853:
6848:
6839:
6837:
6831:
6830:
6828:
6827:
6818:
6817:
6805:
6804:
6799:
6794:
6789:
6784:
6779:
6774:
6769:
6750:
6749:
6743:
6738:
6733:
6728:
6723:
6718:
6713:
6708:
6703:
6698:
6693:
6688:
6683:
6678:
6673:
6664:
6663:
6654:
6653:
6648:
6643:
6638:
6629:
6628:
6623:
6618:
6616:Gambogic amide
6613:
6608:
6603:
6598:
6593:
6588:
6579:
6577:
6568:
6562:
6561:
6559:
6558:
6550:
6548:
6542:
6541:
6539:
6538:
6533:
6528:
6523:
6518:
6513:
6508:
6503:
6498:
6493:
6488:
6479:
6478:
6473:
6464:
6462:
6456:
6455:
6452:
6451:
6449:
6448:
6439:
6437:
6433:
6432:
6430:
6429:
6420:
6419:
6410:
6408:
6402:
6401:
6399:
6398:
6389:
6388:
6386:Artemin (ARTN)
6379:
6377:
6371:
6370:
6368:
6367:
6358:
6357:
6348:
6346:
6340:
6339:
6337:
6336:
6327:
6326:
6321:
6312:
6310:
6301:
6295:
6294:
6292:
6291:
6286:
6281:
6272:
6271:
6266:
6261:
6256:
6251:
6246:
6241:
6236:
6231:
6226:
6221:
6216:
6211:
6206:
6201:
6196:
6187:
6186:
6164:
6155:
6153:
6147:
6146:
6144:
6143:
6134:
6133:
6121:
6120:
6115:
6110:
6105:
6100:
6095:
6090:
6085:
6073:
6072:
6067:
6062:
6057:
6048:
6047:
6042:
6037:
6032:
6027:
6022:
6017:
6012:
6007:
5998:
5996:
5990:
5989:
5986:
5985:
5983:
5982:
5977:
5968:
5967:
5929:
5927:
5923:
5922:
5920:
5919:
5913:
5904:
5903:
5893:
5891:
5885:
5884:
5882:
5881:
5875:
5870:
5865:
5860:
5855:
5850:
5845:
5840:
5831:
5830:
5825:
5820:
5815:
5810:
5801:
5800:
5795:
5790:
5785:
5780:
5775:
5770:
5760:
5758:
5749:
5743:
5742:
5740:
5739:
5734:
5729:
5724:
5719:
5714:
5709:
5700:
5699:
5694:
5689:
5684:
5679:
5674:
5669:
5664:
5659:
5654:
5649:
5644:
5639:
5634:
5629:
5624:
5619:
5614:
5609:
5604:
5595:
5594:
5585:
5584:
5579:
5569:
5567:
5561:
5560:
5557:
5556:
5554:
5553:
5544:
5542:
5538:
5537:
5535:
5534:
5529:
5495:
5486:
5484:
5478:
5477:
5475:
5474:
5464:
5463:
5458:
5453:
5448:
5414:
5405:
5403:
5397:
5396:
5394:
5393:
5384:
5383:
5378:
5369:
5368:
5363:
5358:
5353:
5348:
5343:
5281:
5272:
5270:
5264:
5263:
5261:
5260:
5255:
5250:
5245:
5240:
5198:
5189:
5187:
5178:
5172:
5171:
5168:
5167:
5165:
5164:
5138:
5133:
5128:
5119:
5117:
5111:
5110:
5108:
5107:
5102:
5097:
5088:
5087:
5065:
5063:
5057:
5056:
5054:
5053:
5048:
5043:
5038:
5033:
5024:
5023:
5018:
5013:
5008:
5003:
4998:
4989:
4988:
4978:
4976:
4970:
4969:
4967:
4966:
4961:
4956:
4951:
4946:
4941:
4936:
4931:
4926:
4921:
4912:
4911:
4906:
4901:
4896:
4891:
4886:
4881:
4876:
4871:
4866:
4861:
4856:
4851:
4846:
4837:
4836:
4831:
4826:
4821:
4816:
4811:
4806:
4801:
4796:
4786:
4784:
4771:
4765:
4764:
4762:
4761:
4756:
4751:
4742:
4740:
4734:
4733:
4731:
4730:
4724:
4714:
4713:
4708:
4703:
4694:
4693:
4691:Angiopoietin 3
4688:
4686:Angiopoietin 2
4679:
4678:
4676:Angiopoietin 4
4673:
4671:Angiopoietin 1
4664:
4662:
4656:
4655:
4647:
4645:
4644:
4637:
4630:
4622:
4613:
4612:
4610:
4609:
4596:
4583:
4570:
4557:
4544:
4531:
4517:
4515:
4511:
4510:
4508:
4507:
4502:
4497:
4492:
4487:
4481:
4479:
4475:
4474:
4472:
4471:
4466:
4461:
4456:
4450:
4448:
4447:Classification
4444:
4443:
4441:
4440:
4435:
4430:
4425:
4419:
4417:
4413:
4412:
4410:
4409:
4404:
4399:
4394:
4389:
4384:
4379:
4374:
4368:
4366:
4362:
4361:
4356:
4354:
4353:
4346:
4339:
4331:
4322:
4321:
4318:
4317:
4314:
4313:
4311:
4310:
4305:
4299:
4297:
4290:
4289:
4287:
4286:
4281:
4276:
4271:
4266:
4260:
4258:
4251:
4250:
4248:
4247:
4242:
4237:
4232:
4226:
4224:
4220:
4219:
4217:
4216:
4211:
4206:
4201:
4195:
4193:
4189:
4188:
4186:
4185:
4180:
4175:
4170:
4164:
4162:
4155:
4154:
4152:
4151:
4146:
4141:
4135:
4133:
4126:
4125:
4123:
4122:
4117:
4111:
4109:
4102:
4101:
4099:
4098:
4093:
4087:
4085:
4078:
4077:
4075:
4074:
4069:
4063:
4061:
4054:
4053:
4051:
4050:
4045:
4039:
4037:
4030:
4029:
4027:
4026:
4021:
4015:
4013:
4002:
4001:
3995:
3988:
3987:
3984:
3983:
3980:
3979:
3977:
3976:
3970:
3968:
3964:
3963:
3961:
3960:
3954:
3952:
3945:
3944:
3942:
3941:
3936:
3931:
3925:
3923:
3916:
3915:
3913:
3912:
3907:
3901:
3899:
3896:AATYK receptor
3892:
3891:
3889:
3888:
3882:
3880:
3876:
3875:
3873:
3872:
3866:
3864:
3857:
3856:
3854:
3853:
3847:
3845:
3838:
3837:
3835:
3834:
3828:
3826:
3819:
3818:
3816:
3815:
3810:
3804:
3802:
3795:
3794:
3792:
3791:
3786:
3780:
3778:
3771:
3770:
3768:
3767:
3762:
3756:
3754:
3747:
3746:
3744:
3743:
3738:
3732:
3730:
3723:
3722:
3720:
3719:
3714:
3709:
3704:
3699:
3694:
3689:
3684:
3679:
3674:
3669:
3664:
3659:
3654:
3649:
3643:
3641:
3634:
3633:
3630:
3629:
3627:
3626:
3621:
3616:
3610:
3608:
3601:
3600:
3598:
3597:
3592:
3586:
3584:
3577:
3576:
3574:
3573:
3568:
3563:
3557:
3555:
3552:VEGF receptors
3548:
3547:
3545:
3544:
3539:
3534:
3529:
3523:
3521:
3514:
3513:
3511:
3510:
3504:
3495:
3490:
3485:
3479:
3477:
3471:
3470:
3468:
3467:
3462:
3457:
3451:
3449:
3442:
3441:
3439:
3438:
3433:
3428:
3423:
3417:
3415:
3406:
3396:
3395:
3389:
3382:
3381:
3367:
3365:
3364:
3357:
3350:
3342:
3333:
3332:
3330:
3329:
3328:
3327:
3316:
3314:
3310:
3309:
3307:
3306:
3301:
3300:
3299:
3294:
3283:
3281:
3279:Ig superfamily
3275:
3274:
3272:
3271:
3261:
3259:
3253:
3252:
3249:
3248:
3246:
3245:
3244:
3243:
3238:
3233:
3222:
3219:
3218:
3216:
3215:
3205:
3202:
3201:
3199:
3198:
3197:
3196:
3185:
3182:
3181:
3179:
3178:
3172:
3169:
3168:
3166:
3165:
3164:
3163:
3158:
3153:
3143:high affinity
3135:
3132:
3131:
3129:
3128:
3127:
3126:
3121:
3116:
3111:
3100:
3094:
3088:
3087:
3085:
3084:
3083:
3082:
3077:
3067:
3066:
3065:
3060:
3050:
3049:
3048:
3043:
3028:
3026:
3020:
3019:
3017:
3016:
3014:Erythropoietin
3011:
3001:
2999:
2993:
2992:
2983:
2981:
2980:
2973:
2966:
2958:
2949:
2948:
2946:
2945:
2940:
2935:
2929:
2927:
2923:
2922:
2919:
2918:
2916:
2915:
2910:
2904:
2902:
2893:
2887:
2886:
2883:
2882:
2879:
2878:
2876:
2875:
2869:
2867:
2863:
2862:
2860:
2859:
2854:
2853:
2852:
2847:
2836:
2834:
2827:
2821:
2820:
2817:
2816:
2814:
2813:
2807:
2805:
2801:
2800:
2798:
2797:
2792:
2786:
2784:
2777:
2771:
2770:
2767:
2766:
2764:
2763:
2758:
2752:
2750:
2743:
2733:
2732:
2729:
2728:
2726:
2725:
2716:
2711:
2706:
2700:
2698:
2694:
2693:
2691:
2690:
2685:
2680:
2674:
2672:
2665:
2656:
2650:
2649:
2646:
2645:
2642:
2641:
2639:
2638:
2632:
2630:
2626:
2625:
2623:
2622:
2616:
2614:
2607:
2603:
2602:
2599:
2598:
2596:
2595:
2589:
2587:
2583:
2582:
2580:
2579:
2574:
2569:
2563:
2561:
2554:
2548:
2547:
2544:
2543:
2541:
2540:
2534:
2532:
2525:
2519:
2518:
2515:
2514:
2512:
2511:
2505:
2503:
2499:
2498:
2496:
2495:
2489:
2487:
2480:
2474:
2473:
2470:
2469:
2467:
2466:
2461:
2455:
2453:
2446:
2440:
2439:
2436:
2435:
2433:
2432:
2426:
2424:
2420:
2419:
2417:
2416:
2410:
2408:
2401:
2392:
2386:
2385:
2382:
2381:
2378:
2377:
2375:
2374:
2369:
2363:
2361:
2354:
2348:
2347:
2344:
2343:
2341:
2340:
2335:
2330:
2329:
2328:
2323:
2308:
2306:
2299:
2293:
2292:
2289:
2288:
2286:
2285:
2279:
2277:
2270:
2264:
2263:
2260:
2259:
2257:
2256:
2250:
2248:
2241:
2235:
2234:
2231:
2230:
2228:
2227:
2221:
2219:
2212:
2203:
2197:
2196:
2193:
2192:
2189:
2188:
2186:
2185:
2180:
2174:
2172:
2165:
2163:Growth factors
2156:
2150:
2149:
2140:
2138:
2137:
2130:
2123:
2115:
2108:
2107:
2094:
2074:
2065:
2045:
1987:
1967:
1943:
1924:(2): 177â184.
1903:
1888:
1847:
1812:
1763:
1719:
1684:
1649:(2): 127â137.
1633:
1566:
1506:
1452:
1380:
1361:(12): 649â56.
1345:
1296:
1237:
1216:(4): 317â328.
1196:
1175:(2): 507â517.
1155:
1098:
1069:(3): 460â467.
1049:
1030:(3): 129â137.
1014:
985:(6): 763â773.
965:
903:
874:(6): 669â672.
849:
820:(3): 541â552.
814:Molecular Cell
793:
779:
719:
683:
681:
678:
622:
621:Role in cancer
619:
575:
574:
571:
568:
565:
562:
554:
553:
550:
547:
544:
541:
533:
532:
529:
526:
523:
520:
512:
511:
508:
505:
502:
499:
491:
490:
487:
484:
481:
478:
470:
469:
466:
463:
460:
457:
449:
448:
445:
442:
439:
436:
428:
427:
424:
421:
418:
415:
407:
406:
403:
400:
397:
394:
386:
385:
382:
379:
376:
373:
365:
364:
361:
358:
355:
352:
344:
343:
338:
333:
328:
323:
320:
319:
312:
279:growth factors
255:
252:
192:
189:
185:
184:
178:
172:
167:in humans and
161:
149:
148:Family members
146:
72:
71:
66:
60:
59:
54:
48:
47:
44:
40:
39:
35:
34:
26:
24:
14:
13:
10:
9:
6:
4:
3:
2:
7616:
7605:
7602:
7600:
7597:
7595:
7592:
7591:
7589:
7579:
7574:
7569:
7565:
7551:
7548:
7545:
7544:
7541:
7538:
7535:
7531:
7528:
7526:
7523:
7521:
7518:
7516:
7513:
7511:
7508:
7506:
7503:
7501:
7498:
7496:
7493:
7491:
7488:
7485:
7481:
7477:
7474:
7472:
7469:
7467:
7464:
7462:
7459:
7456:
7452:
7449:
7446:
7442:
7438:
7434:
7430:
7426:
7422:
7418:
7414:
7411:
7409:
7406:
7403:
7399:
7396:
7394:
7391:
7388:
7387:
7385:
7381:
7375:
7372:
7369:
7368:
7365:
7362:
7360:
7357:
7355:
7352:
7350:
7347:
7345:
7342:
7339:
7338:
7335:
7332:
7330:
7327:
7325:
7322:
7320:
7317:
7315:
7312:
7310:
7307:
7305:
7302:
7300:
7297:
7295:
7292:
7290:
7287:
7285:
7282:
7280:
7277:
7275:
7272:
7270:
7267:
7265:
7262:
7260:
7257:
7255:
7252:
7250:
7247:
7245:
7242:
7240:
7237:
7235:
7232:
7229:
7228:
7225:
7224:Cyclotraxin B
7222:
7219:
7218:
7214:
7210:
7206:
7202:
7198:
7195:
7193:
7190:
7188:
7185:
7183:
7180:
7177:
7176:
7174:
7172:
7168:
7158:
7155:
7153:
7150:
7148:
7145:
7143:
7140:
7138:
7137:Larotrectinib
7135:
7133:
7130:
7128:
7125:
7123:
7120:
7118:
7115:
7113:
7110:
7108:
7105:
7103:
7100:
7098:
7095:
7092:
7091:
7088:
7085:
7083:
7080:
7078:
7075:
7072:
7071:
7069:
7067:
7063:
7057:
7054:
7052:
7049:
7047:
7044:
7042:
7039:
7037:
7036:Larotrectinib
7034:
7032:
7029:
7027:
7024:
7022:
7019:
7017:
7014:
7012:
7009:
7007:
7004:
7002:
6999:
6997:
6994:
6991:
6990:
6987:
6984:
6981:
6980:
6977:
6974:
6972:
6971:Cyclotraxin B
6969:
6967:
6964:
6961:
6960:
6957:
6954:
6952:
6949:
6947:
6944:
6942:
6939:
6937:
6934:
6932:
6929:
6927:
6924:
6922:
6919:
6917:
6914:
6912:
6909:
6907:
6904:
6902:
6899:
6897:
6894:
6892:
6889:
6887:
6884:
6882:
6881:Amitriptyline
6879:
6877:
6874:
6872:
6869:
6867:
6864:
6862:
6859:
6857:
6854:
6852:
6849:
6847:
6844:
6841:
6840:
6838:
6836:
6832:
6826:
6823:
6820:
6819:
6816:
6813:
6810:
6807:
6806:
6803:
6800:
6798:
6795:
6793:
6790:
6788:
6785:
6783:
6780:
6778:
6775:
6773:
6770:
6768:
6765:
6761:
6758:
6757:Against TrkA:
6755:
6752:
6751:
6747:
6744:
6742:
6739:
6737:
6734:
6732:
6729:
6727:
6724:
6722:
6719:
6717:
6714:
6712:
6711:Larotrectinib
6709:
6707:
6704:
6702:
6699:
6697:
6694:
6692:
6689:
6687:
6684:
6682:
6679:
6677:
6674:
6672:
6669:
6666:
6665:
6662:
6659:
6656:
6655:
6652:
6649:
6647:
6644:
6642:
6641:Dexamethasone
6639:
6637:
6634:
6631:
6630:
6627:
6624:
6622:
6619:
6617:
6614:
6612:
6609:
6607:
6604:
6602:
6599:
6597:
6594:
6592:
6589:
6587:
6586:Amitriptyline
6584:
6581:
6580:
6578:
6576:
6572:
6569:
6567:
6563:
6556:
6552:
6551:
6549:
6547:
6543:
6537:
6534:
6532:
6529:
6527:
6524:
6522:
6519:
6517:
6514:
6512:
6509:
6507:
6504:
6502:
6499:
6497:
6494:
6492:
6489:
6487:
6484:
6481:
6480:
6477:
6474:
6472:
6469:
6466:
6465:
6463:
6461:
6457:
6447:
6444:
6441:
6440:
6438:
6434:
6428:
6425:
6422:
6421:
6418:
6415:
6412:
6411:
6409:
6407:
6403:
6397:
6394:
6391:
6390:
6387:
6384:
6381:
6380:
6378:
6376:
6372:
6366:
6363:
6360:
6359:
6356:
6353:
6350:
6349:
6347:
6345:
6341:
6335:
6332:
6329:
6328:
6325:
6322:
6320:
6317:
6314:
6313:
6311:
6309:
6305:
6302:
6300:
6296:
6290:
6287:
6285:
6282:
6280:
6277:
6274:
6273:
6270:
6267:
6265:
6262:
6260:
6257:
6255:
6252:
6250:
6247:
6245:
6242:
6240:
6237:
6235:
6232:
6230:
6227:
6225:
6222:
6220:
6217:
6215:
6212:
6210:
6207:
6205:
6202:
6200:
6197:
6195:
6192:
6189:
6188:
6184:
6180:
6176:
6172:
6168:
6165:
6163:
6160:
6157:
6156:
6154:
6152:
6148:
6142:
6139:
6136:
6135:
6132:
6129:
6126:
6123:
6122:
6119:
6116:
6114:
6111:
6109:
6106:
6104:
6101:
6099:
6096:
6094:
6091:
6089:
6086:
6084:
6081:
6078:
6075:
6074:
6071:
6068:
6066:
6063:
6061:
6060:Dexamethasone
6058:
6056:
6053:
6050:
6049:
6046:
6043:
6041:
6038:
6036:
6033:
6031:
6028:
6026:
6023:
6021:
6018:
6016:
6013:
6011:
6008:
6006:
6003:
6000:
5999:
5997:
5995:
5991:
5981:
5978:
5976:
5973:
5970:
5969:
5965:
5961:
5957:
5953:
5949:
5945:
5941:
5937:
5934:
5931:
5930:
5928:
5924:
5917:
5914:
5912:
5909:
5906:
5905:
5902:
5898:
5895:
5894:
5892:
5890:
5886:
5879:
5876:
5874:
5871:
5869:
5866:
5864:
5861:
5859:
5856:
5854:
5851:
5849:
5846:
5844:
5841:
5839:
5836:
5833:
5832:
5829:
5826:
5824:
5821:
5819:
5816:
5814:
5811:
5809:
5806:
5803:
5802:
5799:
5796:
5794:
5791:
5789:
5786:
5784:
5781:
5779:
5776:
5774:
5771:
5769:
5768:des(1-3)IGF-1
5765:
5762:
5761:
5759:
5757:
5753:
5750:
5748:
5744:
5738:
5735:
5733:
5732:Telisotuzumab
5730:
5728:
5725:
5723:
5720:
5718:
5715:
5713:
5710:
5708:
5705:
5702:
5701:
5698:
5695:
5693:
5690:
5688:
5685:
5683:
5680:
5678:
5675:
5673:
5670:
5668:
5665:
5663:
5660:
5658:
5655:
5653:
5650:
5648:
5645:
5643:
5640:
5638:
5635:
5633:
5630:
5628:
5625:
5623:
5620:
5618:
5615:
5613:
5610:
5608:
5605:
5603:
5600:
5597:
5596:
5593:
5590:
5589:Potentiators:
5587:
5586:
5583:
5580:
5578:
5574:
5571:
5570:
5568:
5566:
5562:
5552:
5549:
5546:
5545:
5543:
5539:
5533:
5530:
5527:
5523:
5519:
5515:
5511:
5507:
5503:
5499:
5496:
5494:
5491:
5488:
5487:
5485:
5483:
5479:
5472:
5469:
5466:
5465:
5462:
5459:
5457:
5454:
5452:
5451:Selpercatinib
5449:
5446:
5442:
5438:
5434:
5430:
5426:
5422:
5418:
5415:
5413:
5410:
5407:
5406:
5404:
5402:
5398:
5392:
5389:
5386:
5385:
5382:
5379:
5377:
5374:
5371:
5370:
5367:
5364:
5362:
5359:
5357:
5356:Selpercatinib
5354:
5352:
5349:
5347:
5344:
5341:
5337:
5333:
5329:
5325:
5321:
5317:
5313:
5309:
5305:
5301:
5297:
5293:
5289:
5285:
5282:
5280:
5277:
5274:
5273:
5271:
5269:
5265:
5259:
5256:
5254:
5251:
5249:
5248:Selpercatinib
5246:
5244:
5241:
5238:
5234:
5230:
5226:
5222:
5218:
5214:
5210:
5206:
5202:
5199:
5197:
5194:
5191:
5190:
5188:
5186:
5182:
5179:
5177:
5173:
5162:
5158:
5154:
5150:
5146:
5142:
5139:
5137:
5134:
5132:
5129:
5127:
5124:
5121:
5120:
5118:
5116:
5112:
5106:
5103:
5101:
5098:
5096:
5093:
5090:
5089:
5085:
5081:
5077:
5073:
5070:
5067:
5066:
5064:
5062:
5058:
5052:
5049:
5047:
5044:
5042:
5039:
5037:
5034:
5032:
5029:
5026:
5025:
5022:
5019:
5017:
5014:
5012:
5009:
5007:
5004:
5002:
4999:
4997:
4994:
4991:
4990:
4987:
4983:
4980:
4979:
4977:
4975:
4971:
4965:
4962:
4960:
4957:
4955:
4952:
4950:
4947:
4945:
4942:
4940:
4937:
4935:
4932:
4930:
4927:
4925:
4924:Depatuxizumab
4922:
4920:
4917:
4914:
4913:
4910:
4907:
4905:
4902:
4900:
4897:
4895:
4892:
4890:
4887:
4885:
4882:
4880:
4877:
4875:
4872:
4870:
4867:
4865:
4862:
4860:
4857:
4855:
4852:
4850:
4847:
4845:
4842:
4839:
4838:
4835:
4832:
4830:
4827:
4825:
4822:
4820:
4817:
4815:
4812:
4810:
4807:
4805:
4802:
4800:
4797:
4795:
4791:
4788:
4787:
4785:
4783:
4775:
4772:
4770:
4766:
4760:
4757:
4755:
4752:
4750:
4747:
4744:
4743:
4741:
4739:
4735:
4728:
4725:
4722:
4719:
4716:
4715:
4712:
4709:
4707:
4704:
4702:
4699:
4696:
4695:
4692:
4689:
4687:
4684:
4681:
4680:
4677:
4674:
4672:
4669:
4666:
4665:
4663:
4661:
4657:
4653:
4650:
4643:
4638:
4636:
4631:
4629:
4624:
4623:
4620:
4607:
4603:
4602:
4597:
4594:
4590:
4589:
4584:
4581:
4577:
4576:
4571:
4568:
4564:
4563:
4558:
4555:
4551:
4550:
4545:
4542:
4538:
4537:
4532:
4529:
4525:
4524:
4519:
4518:
4516:
4512:
4506:
4503:
4501:
4498:
4496:
4493:
4491:
4488:
4486:
4483:
4482:
4480:
4476:
4470:
4467:
4465:
4464:Enzyme family
4462:
4460:
4457:
4455:
4452:
4451:
4449:
4445:
4439:
4436:
4434:
4431:
4429:
4428:Cooperativity
4426:
4424:
4421:
4420:
4418:
4414:
4408:
4405:
4403:
4400:
4398:
4395:
4393:
4390:
4388:
4387:Oxyanion hole
4385:
4383:
4380:
4378:
4375:
4373:
4370:
4369:
4367:
4363:
4359:
4352:
4347:
4345:
4340:
4338:
4333:
4332:
4329:
4309:
4306:
4304:
4301:
4300:
4298:
4295:
4291:
4285:
4282:
4280:
4277:
4275:
4272:
4270:
4267:
4265:
4262:
4261:
4259:
4256:
4252:
4246:
4243:
4241:
4238:
4236:
4233:
4231:
4228:
4227:
4225:
4221:
4215:
4212:
4210:
4207:
4205:
4202:
4200:
4197:
4196:
4194:
4190:
4184:
4181:
4179:
4176:
4174:
4171:
4169:
4166:
4165:
4163:
4160:
4156:
4150:
4147:
4145:
4142:
4140:
4137:
4136:
4134:
4131:
4127:
4121:
4118:
4116:
4113:
4112:
4110:
4107:
4103:
4097:
4094:
4092:
4089:
4088:
4086:
4083:
4079:
4073:
4070:
4068:
4065:
4064:
4062:
4059:
4055:
4049:
4046:
4044:
4041:
4040:
4038:
4035:
4031:
4025:
4022:
4020:
4017:
4016:
4014:
4011:
4007:
4003:
3999:(EC 2.7.10.2)
3998:
3993:
3989:
3975:
3972:
3971:
3969:
3967:uncategorised
3965:
3959:
3956:
3955:
3953:
3950:
3946:
3940:
3937:
3935:
3932:
3930:
3927:
3926:
3924:
3921:
3917:
3911:
3908:
3906:
3903:
3902:
3900:
3897:
3893:
3887:
3884:
3883:
3881:
3877:
3871:
3868:
3867:
3865:
3862:
3861:MuSK receptor
3858:
3852:
3849:
3848:
3846:
3843:
3839:
3833:
3830:
3829:
3827:
3824:
3823:PTK7 receptor
3820:
3814:
3811:
3809:
3806:
3805:
3803:
3800:
3796:
3790:
3787:
3785:
3782:
3781:
3779:
3776:
3772:
3766:
3763:
3761:
3758:
3757:
3755:
3752:
3748:
3742:
3739:
3737:
3734:
3733:
3731:
3728:
3724:
3718:
3715:
3713:
3710:
3708:
3705:
3703:
3700:
3698:
3695:
3693:
3690:
3688:
3685:
3683:
3680:
3678:
3675:
3673:
3670:
3668:
3665:
3663:
3660:
3658:
3655:
3653:
3650:
3648:
3645:
3644:
3642:
3639:
3635:
3625:
3622:
3620:
3617:
3615:
3612:
3611:
3609:
3606:
3602:
3596:
3593:
3591:
3588:
3587:
3585:
3582:
3578:
3572:
3569:
3567:
3564:
3562:
3559:
3558:
3556:
3553:
3549:
3543:
3540:
3538:
3535:
3533:
3530:
3528:
3525:
3524:
3522:
3519:
3515:
3508:
3505:
3503:
3499:
3496:
3494:
3491:
3489:
3486:
3484:
3481:
3480:
3478:
3476:
3472:
3466:
3463:
3461:
3458:
3456:
3453:
3452:
3450:
3447:
3443:
3437:
3434:
3432:
3429:
3427:
3424:
3422:
3419:
3418:
3416:
3414:
3410:
3407:
3405:
3401:
3397:
3393:(EC 2.7.10.1)
3392:
3387:
3383:
3378:
3374:
3370:
3363:
3358:
3356:
3351:
3349:
3344:
3343:
3340:
3326:
3323:
3322:
3321:
3318:
3317:
3315:
3311:
3305:
3302:
3298:
3295:
3293:
3290:
3289:
3288:
3285:
3284:
3282:
3280:
3276:
3270:
3266:
3263:
3262:
3260:
3258:
3254:
3242:
3239:
3237:
3234:
3232:
3229:
3228:
3227:
3224:
3223:
3220:
3214:
3210:
3207:
3206:
3203:
3195:
3192:
3191:
3190:
3187:
3186:
3183:
3177:
3174:
3173:
3170:
3162:
3159:
3157:
3154:
3152:
3149:
3148:
3147:
3146:
3140:
3137:
3136:
3133:
3125:
3122:
3120:
3117:
3115:
3112:
3110:
3107:
3106:
3105:
3102:
3101:
3098:
3095:
3093:
3089:
3081:
3078:
3076:
3073:
3072:
3071:
3068:
3064:
3061:
3059:
3056:
3055:
3054:
3051:
3047:
3044:
3042:
3039:
3038:
3037:
3033:
3030:
3029:
3027:
3025:
3021:
3015:
3012:
3010:
3006:
3003:
3002:
3000:
2998:
2994:
2990:
2986:
2979:
2974:
2972:
2967:
2965:
2960:
2959:
2956:
2944:
2941:
2939:
2936:
2934:
2931:
2930:
2928:
2924:
2914:
2911:
2909:
2906:
2905:
2903:
2901:
2897:
2894:
2892:
2891:Mitochondrion
2888:
2874:
2871:
2870:
2868:
2864:
2858:
2855:
2851:
2848:
2846:
2843:
2842:
2841:
2838:
2837:
2835:
2831:
2828:
2826:
2822:
2812:
2809:
2808:
2806:
2802:
2796:
2793:
2791:
2788:
2787:
2785:
2781:
2778:
2776:
2772:
2762:
2759:
2757:
2754:
2753:
2751:
2747:
2744:
2742:
2738:
2734:
2724:
2720:
2717:
2715:
2712:
2710:
2707:
2705:
2702:
2701:
2699:
2695:
2689:
2686:
2684:
2681:
2679:
2676:
2675:
2673:
2669:
2666:
2664:
2660:
2657:
2655:
2651:
2637:
2634:
2633:
2631:
2627:
2621:
2618:
2617:
2615:
2611:
2608:
2606:Other/unknown
2604:
2594:
2591:
2590:
2588:
2584:
2578:
2575:
2573:
2570:
2568:
2565:
2564:
2562:
2558:
2555:
2553:
2549:
2539:
2536:
2535:
2533:
2529:
2526:
2524:
2520:
2510:
2507:
2506:
2504:
2500:
2494:
2491:
2490:
2488:
2484:
2481:
2479:
2475:
2465:
2462:
2460:
2457:
2456:
2454:
2450:
2447:
2445:
2441:
2431:
2428:
2427:
2425:
2421:
2415:
2412:
2411:
2409:
2405:
2402:
2400:
2396:
2393:
2391:
2387:
2373:
2370:
2368:
2365:
2364:
2362:
2358:
2355:
2353:
2349:
2339:
2336:
2334:
2331:
2327:
2324:
2322:
2319:
2318:
2317:
2313:
2310:
2309:
2307:
2303:
2300:
2298:
2294:
2284:
2281:
2280:
2278:
2274:
2271:
2269:
2265:
2255:
2252:
2251:
2249:
2245:
2242:
2240:
2236:
2226:
2223:
2222:
2220:
2216:
2213:
2211:
2207:
2204:
2202:
2198:
2184:
2181:
2179:
2176:
2175:
2173:
2169:
2166:
2164:
2160:
2157:
2155:
2151:
2147:
2143:
2136:
2131:
2129:
2124:
2122:
2117:
2116:
2113:
2105:
2098:
2095:
2084:
2078:
2075:
2069:
2066:
2055:
2049:
2046:
2041:
2037:
2033:
2029:
2024:
2019:
2015:
2011:
2007:
2003:
1999:
1991:
1988:
1977:
1971:
1968:
1962:
1960:
1958:
1956:
1954:
1952:
1950:
1948:
1944:
1939:
1935:
1931:
1927:
1923:
1919:
1912:
1910:
1908:
1904:
1897:
1895:
1893:
1889:
1884:
1880:
1875:
1870:
1866:
1862:
1858:
1851:
1848:
1843:
1839:
1835:
1831:
1828:(10): 31â53.
1827:
1823:
1822:Exp. Cell Res
1816:
1813:
1808:
1804:
1799:
1794:
1790:
1786:
1782:
1778:
1774:
1767:
1764:
1759:
1755:
1750:
1745:
1741:
1737:
1733:
1726:
1724:
1720:
1715:
1711:
1707:
1703:
1699:
1695:
1688:
1685:
1680:
1676:
1672:
1668:
1664:
1660:
1656:
1652:
1648:
1644:
1637:
1634:
1629:
1625:
1620:
1615:
1611:
1607:
1602:
1597:
1593:
1589:
1586:(3): e58148.
1585:
1581:
1577:
1570:
1567:
1562:
1558:
1553:
1548:
1544:
1540:
1536:
1532:
1528:
1524:
1520:
1513:
1511:
1507:
1502:
1498:
1493:
1488:
1484:
1480:
1476:
1472:
1468:
1461:
1459:
1457:
1453:
1448:
1444:
1439:
1434:
1430:
1426:
1421:
1416:
1412:
1408:
1404:
1400:
1396:
1389:
1387:
1385:
1381:
1376:
1372:
1368:
1364:
1360:
1356:
1349:
1346:
1341:
1337:
1333:
1329:
1324:
1319:
1316:(6): 763â73.
1315:
1311:
1307:
1300:
1297:
1292:
1288:
1283:
1278:
1273:
1268:
1264:
1260:
1256:
1252:
1248:
1241:
1238:
1233:
1229:
1224:
1219:
1215:
1211:
1207:
1200:
1197:
1192:
1188:
1183:
1178:
1174:
1170:
1166:
1159:
1156:
1151:
1147:
1143:
1139:
1134:
1129:
1125:
1121:
1117:
1113:
1109:
1102:
1099:
1094:
1090:
1085:
1080:
1076:
1072:
1068:
1064:
1060:
1053:
1050:
1045:
1041:
1037:
1033:
1029:
1025:
1018:
1015:
1010:
1006:
1002:
998:
993:
988:
984:
980:
976:
969:
966:
961:
957:
953:
949:
945:
941:
936:
931:
927:
923:
919:
912:
910:
908:
904:
899:
895:
891:
887:
882:
877:
873:
869:
865:
858:
856:
854:
850:
845:
841:
837:
833:
828:
823:
819:
815:
811:
804:
802:
800:
798:
794:
788:
786:
784:
780:
775:
771:
767:
763:
758:
753:
749:
745:
741:
737:
733:
726:
724:
720:
715:
711:
707:
703:
700:(2): 124â34.
699:
695:
688:
685:
679:
677:
673:
671:
667:
663:
659:
655:
651:
647:
642:
638:
634:
632:
628:
620:
618:
615:
611:
607:
603:
598:
593:
591:
587:
582:
572:
569:
566:
563:
561:
560:
556:
555:
551:
548:
545:
542:
540:
539:
535:
534:
530:
527:
524:
521:
519:
518:
514:
513:
509:
506:
503:
500:
498:
497:
493:
492:
488:
485:
482:
479:
477:
476:
472:
471:
467:
464:
461:
458:
456:
455:
451:
450:
446:
443:
440:
437:
435:
434:
430:
429:
425:
422:
419:
416:
414:
413:
409:
408:
404:
401:
398:
395:
393:
392:
388:
387:
383:
380:
377:
374:
372:
371:
367:
366:
362:
359:
356:
353:
351:
350:
346:
345:
342:
339:
337:
334:
332:
329:
327:
324:
322:
321:
318:
317:
311:
310:
306:
305:
299:
295:
289:
285:
282:
280:
276:
273:
272:growth factor
269:
265:
261:
253:
247:
243:
241:
238:(ErbB-3) and
237:
233:
229:
225:
220:
218:
214:
210:
206:
205:transmembrane
202:
198:
197:extracellular
190:
188:
183:
179:
177:
173:
170:
166:
162:
159:
155:
154:
153:
147:
145:
143:
139:
135:
131:
127:
121:
119:
115:
111:
107:
103:
100:), and Her4 (
99:
95:
91:
87:
83:
79:
70:
67:
65:
61:
58:
55:
53:
49:
45:
41:
36:
31:
19:
7550:Cerebrolysin
7546:
7520:Pleiotrophin
7476:Interleukins
7389:
7370:
7340:
7259:Fruquintinib
7249:Cabozantinib
7230:
7220:
7178:
7142:Lestaurtinib
7093:
7073:
7041:Lestaurtinib
6992:
6982:
6963:Antagonists:
6962:
6896:Deoxygedunin
6851:3,7,8,2'-THF
6842:
6821:
6812:Against NGF:
6811:
6808:
6764:Against NGF:
6763:
6756:
6753:
6716:Lestaurtinib
6667:
6657:
6651:Testosterone
6633:Antagonists:
6632:
6582:
6482:
6467:
6442:
6423:
6413:
6392:
6382:
6361:
6351:
6330:
6315:
6275:
6190:
6158:
6137:
6128:Against NGF:
6127:
6124:
6080:Against NGF:
6079:
6076:
6070:Testosterone
6052:Antagonists:
6051:
6001:
5971:
5932:
5907:
5896:
5873:Teprotumumab
5834:
5804:
5763:
5712:Ficlatuzumab
5707:Emibetuzumab
5703:
5657:JNJ-38877605
5627:Cabozantinib
5598:
5588:
5577:Fosgonimeton
5572:
5547:
5489:
5467:
5408:
5391:Infigratinib
5387:
5372:
5275:
5192:
5126:Betacellulin
5122:
5105:Seribantumab
5091:
5068:
5027:
4992:
4986:Unknown/none
4985:
4981:
4915:
4840:
4799:Betacellulin
4794:Amphiregulin
4789:
4781:(ErbB1/HER1)
4745:
4717:
4697:
4683:Antagonists:
4682:
4667:
4660:Angiopoietin
4601:Translocases
4598:
4585:
4572:
4559:
4546:
4536:Transferases
4533:
4520:
4377:Binding site
4223:SRC-B family
4192:SRC-A family
3949:RET receptor
3920:AXL receptor
3842:RYK receptor
3799:DDR receptor
3775:ROR receptor
3751:TIE receptor
3727:LTK receptor
3638:EPH receptor
3605:Trk receptor
3581:HGF receptor
3518:FGF receptor
3412:
3208:
3142:
2414:Beta-catenin
2311:
2097:
2086:. Retrieved
2077:
2068:
2057:. Retrieved
2048:
2005:
2001:
1990:
1979:. Retrieved
1970:
1921:
1917:
1864:
1860:
1850:
1825:
1821:
1815:
1780:
1776:
1766:
1739:
1735:
1697:
1693:
1687:
1646:
1642:
1636:
1583:
1579:
1569:
1529:(1): 15â31.
1526:
1522:
1474:
1470:
1402:
1398:
1358:
1354:
1348:
1313:
1309:
1299:
1254:
1250:
1240:
1213:
1209:
1199:
1172:
1168:
1158:
1115:
1111:
1101:
1066:
1062:
1052:
1027:
1023:
1017:
982:
978:
968:
925:
921:
871:
867:
817:
813:
739:
735:
697:
693:
687:
674:
643:
639:
635:
624:
604:of specific
596:
594:
578:
559:neuregulin 4
557:
538:neuregulin 3
536:
517:neuregulin 2
515:
496:neuregulin 1
494:
473:
452:
433:betacellulin
431:
412:amphiregulin
410:
389:
368:
347:
340:
335:
330:
325:
314:
307:
283:
264:heterodimers
257:
221:
194:
186:
151:
126:Schwann cell
122:
77:
75:
7604:Human genes
7510:Oncomodulin
7374:Aflibercept
7364:Ranibizumab
7359:Ramucirumab
7349:Bevacizumab
7341:Antibodies:
7299:Regorafenib
7239:Altiratinib
7152:ONO-5390556
7122:Entrectinib
7097:Altiratinib
7051:ONO-5390556
7021:Entrectinib
6996:Altiratinib
6782:Frunevetmab
6754:Antibodies:
6731:ONO-5390556
6696:Entrectinib
6671:Altiratinib
6626:Tavilermide
6521:Quizartinib
6460:SCF (c-Kit)
6284:Ramucirumab
6276:Antibodies:
6249:Quizartinib
6199:Avapritinib
6162:Becaplermin
6098:Frunevetmab
6077:Antibodies:
5980:Trofinetide
5911:Dusigitumab
5908:Antibodies:
5863:Robatumumab
5853:Figitumumab
5848:Dalotuzumab
5843:Cixutumumab
5835:Antibodies:
5727:Rilotumumab
5722:Onartuzumab
5717:Flanvotumab
5704:Antibodies:
5672:PF-04217903
5602:Altiratinib
5565:HGF (c-Met)
5468:Antibodies:
5373:Antibodies:
5095:Duligotumab
5092:Antibodies:
5006:Trastuzumab
4996:Ertumaxomab
4993:Antibodies:
4964:Zalutumumab
4959:Panitumumab
4954:Nimotuzumab
4949:Necitumumab
4939:Imgatuzumab
4916:Antibodies:
4899:Osimertinib
4864:Dacomitinib
4759:Dapiclermin
4718:Antibodies:
4701:Altiratinib
4372:Active site
3320:Somatomedin
3189:Somatomedin
3032:TGF pathway
1867:(2): 21â6.
1210:Cancer Cell
670:AKT pathway
646:panitumumab
203:, a single
201:amino acids
38:Identifiers
18:EGFR family
7588:Categories
7329:Vandetanib
7294:Rebastinib
7289:Pegaptanib
7279:Nintedanib
7269:Lenvatinib
7234:Agerafenib
7187:Ripretinib
7112:CH-7057288
7011:CH-7057288
6876:7,8,3'-THF
6871:7,8,2'-THF
6797:Ranevetmab
6787:Fulranumab
6741:Rebastinib
6686:CH-7057288
6601:Cenegermin
6486:Agerafenib
6446:Agerafenib
6427:Vandetanib
6396:Vandetanib
6365:Vandetanib
6334:Vandetanib
6279:Olaratumab
6254:Ripretinib
6234:Nintedanib
6219:Lenvatinib
6209:Crenolanib
6194:Agerafenib
6113:Ranevetmab
6103:Fulranumab
6020:Cenegermin
5994:LNGF (p75)
5916:Xentuzumab
5878:Xentuzumab
5823:NVP-AEW541
5818:NVP-ADW742
5813:Linsitinib
5808:BMS-754807
5793:Mecasermin
5692:Tivantinib
5682:PHA-665752
5677:PF-2341066
5647:Golvatinib
5637:Crizotinib
5632:Capmatinib
5622:BMS-777607
5617:Amuvatinib
5493:Ersofermin
5456:Sprifermin
5412:Ersofermin
5361:Sprifermin
5351:Repifermin
5346:Palifermin
5279:Ersofermin
5258:Velafermin
5243:Repifermin
5196:Ersofermin
5115:ErbB4/HER4
5100:Patritumab
5061:ErbB3/HER3
5041:Mubritinib
5001:Pertuzumab
4974:ErbB2/HER2
4904:Vandetanib
4859:Canertinib
4854:Brigatinib
4849:Agerafenib
4829:Nepidermin
4824:Murodermin
4814:Epiregulin
4769:EGF (ErbB)
4727:Nesvacumab
4721:Evinacumab
4711:Rebastinib
4652:modulators
4575:Isomerases
4549:Hydrolases
4416:Regulation
2737:DNA repair
2663:Cell cycle
2178:c-Sis/PDGF
2088:2017-10-30
2059:2007-10-02
1981:2017-10-30
680:References
475:epiregulin
260:homodimers
242:(ErbB-4):
234:(ErbB-2),
230:(ErbB-1),
171:in rodents
138:malignancy
108:, such as
64:Membranome
7599:Oncogenes
7354:Icrucumab
7334:WHI-P 154
7324:Tivozanib
7319:Toceranib
7314:Sunitinib
7309:Sorafenib
7304:Semaxanib
7284:Pazopanib
7274:Motesanib
7264:Lapatinib
7254:Cediranib
7192:Telbermin
7179:Agonists:
7127:GZ-389988
7107:CE-245677
7074:Agonists:
7026:GZ-389988
7006:CE-245677
6906:Diosmetin
6843:Agonists:
6809:Aptamers:
6802:Tanezumab
6777:Fasinumab
6721:Milciclib
6701:GZ-389988
6681:CE-245677
6583:Agonists:
6536:Toceranib
6531:Sunitinib
6526:Sorafenib
6516:Pazopanib
6511:Nilotinib
6506:Masitinib
6496:Dasatinib
6468:Agonists:
6414:Agonists:
6383:Agonists:
6352:Agonists:
6324:Liatermin
6316:Agonists:
6299:RET (GFL)
6289:Tovetumab
6269:Toceranib
6264:Sorafenib
6259:Sunitinib
6244:Radotinib
6239:Pazopanib
6229:Motesanib
6224:Masitinib
6159:Agonists:
6125:Aptamers:
6118:Tanezumab
6093:Fasinumab
6002:Agonists:
5858:Ganitumab
5778:IGF-1 LR3
5697:Volitinib
5652:INCB28060
5642:Foretinib
5548:Agonists:
5532:Trafermin
5490:Agonists:
5471:Burosumab
5461:Trafermin
5409:Agonists:
5376:Aprutumab
5366:Trafermin
5328:10 (KGF2)
5276:Agonists:
5253:Trafermin
5233:10 (KGF2)
5193:Agonists:
5123:Agonists:
5069:Agonists:
5051:Tucatinib
5046:Neratinib
5036:Lapatinib
4944:Matuzumab
4934:Futuximab
4919:Cetuximab
4909:WHI-P 154
4894:Neratinib
4889:Lapatinib
4879:Grandinin
4874:Gefitinib
4869:Erlotinib
4746:Agonists:
4706:CE-245677
4668:Agonists:
4454:EC number
2985:Receptors
2146:Oncogenes
1663:1471-0072
1610:1932-6203
1543:1744-7631
1477:: 47â61.
1429:1932-6203
1169:Mol. Cell
1063:Structure
944:0092-8674
836:1097-2765
658:erlotinib
654:gefitinib
650:cetuximab
614:threonine
597:tethered
590:PI3-K/Akt
268:oligomers
191:Structure
140:of these
96:), Her3 (
92:), Her2 (
57:IPR016245
7536:instead)
7525:Renalase
7486:instead)
7457:instead)
7404:instead)
7244:Axitinib
7213:D (FIGF)
7157:PLX-7486
7147:ONO-4474
7102:AZD-6918
7056:PLX-7486
7046:ONO-4474
7001:AZD-6918
6983:Ligands:
6901:Deprenyl
6861:7,3'-DHF
6792:MEDI-578
6772:ASP-6294
6736:PLX-7486
6726:ONO-4474
6676:AZD-6918
6636:ALE-0540
6557:instead.
6501:Imatinib
6491:Axitinib
6471:Ancestim
6436:Unsorted
6214:Imatinib
6204:Axitinib
6108:MEDI-578
6088:ASP-6294
6055:ALE-0540
5897:Agonists
5838:AVE-1642
5764:Agonists
5687:SU-11274
5573:Agonists
5551:FGF15/19
5541:Unsorted
5506:2 (bFGF)
5425:2 (bFGF)
5292:2 (bFGF)
5209:2 (bFGF)
5031:Afatinib
4982:Agonists
4884:Icotinib
4844:Afatinib
4790:Agonists
4478:Kinetics
4402:Cofactor
4365:Activity
3036:TGF-beta
2943:Stathmin
2688:Cyclin E
2683:Cyclin D
2321:HER2/neu
2201:Receptor
2040:23254145
2032:17463250
1938:19208461
1883:15142631
1842:12648464
1807:16729043
1758:16799092
1714:17085050
1671:11252954
1628:23472148
1580:PLOS ONE
1561:22239438
1501:21892266
1447:26536590
1399:PLOS ONE
1375:17085050
1340:17533948
1332:12297049
1291:16203964
1232:15093539
1191:12620237
1150:23069349
1142:12154198
1093:18334220
1044:17280834
1009:17533948
1001:12297049
960:14256004
952:16777603
890:12297041
844:14527402
774:23069349
766:12154198
714:17314037
662:afatinib
606:tyrosine
316:Receptor
217:cysteine
52:InterPro
7578:Biology
7413:Ephrins
7117:DS-6051
7016:DS-6051
6921:LM22A-4
6911:DMAQ-B1
6866:7,8-DHF
6846:3,7-DHF
6815:RBM-004
6760:GBR-900
6691:DS-6051
6661:VM-902A
6131:RBM-004
5828:OSl-906
5788:Insulin
5667:MK-2461
5612:AMG-458
4749:Axokine
4588:Ligases
4358:Enzymes
3379:2.7.10)
3053:Activin
2933:c-Bcl-2
2741:Fanconi
2654:Nucleus
2010:Bibcode
2002:Science
1798:1681463
1679:4235503
1619:3589378
1588:Bibcode
1552:3291787
1492:3161635
1438:4633289
1407:Bibcode
1282:1257738
1259:Bibcode
1120:Bibcode
1112:Science
1084:2858219
898:8775985
744:Bibcode
736:Science
294:ProtCID
275:ligands
213:leucine
134:cancers
7564:Portal
7383:Others
7077:BNN-20
6966:ANA-12
6891:BNN-20
6611:DHEA-S
6596:BNN-27
6591:BNN-20
6030:DHEA-S
6015:BNN-27
6010:BNN-20
5926:Others
5131:Epigen
4809:Epigen
4562:Lyases
4296:family
4257:family
4161:family
4132:family
4108:family
4084:family
4060:family
4036:family
4012:family
3951:family
3922:family
3910:AATYK2
3898:family
3863:family
3844:family
3825:family
3801:family
3777:family
3753:family
3729:family
3640:family
3607:family
3583:family
3571:VEGFR3
3566:VEGFR2
3561:VEGFR1
3554:family
3520:family
3507:PDGFRB
3502:PDGFRA
3448:family
2723:p14arf
2636:Maspin
2316:c-ErbB
2154:Ligand
2038:
2030:
1936:
1881:
1840:
1805:
1795:
1756:
1712:
1677:
1669:
1661:
1626:
1616:
1608:
1559:
1549:
1541:
1499:
1489:
1445:
1435:
1427:
1373:
1338:
1330:
1289:
1279:
1230:
1189:
1148:
1140:
1091:
1081:
1042:
1007:
999:
958:
950:
942:
896:
888:
842:
834:
772:
764:
712:
612:, and
610:serine
454:epigen
391:HB-EGF
341:ErbB-4
336:ErbB-3
331:ErbB-2
326:ErbB-1
309:Ligand
226:files
160:(EGFR)
142:tumors
43:Symbol
7532:(see
7482:(see
7453:(see
7400:(see
7132:K252a
7031:K252a
6706:K252a
6646:FX007
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224:pdb
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