244:
221:
118:
143:
495:
250:
149:
2444:
2464:
1380:
Metzen E, Berchner-Pfannschmidt U, Stengel P, Marxsen JH, Stolze I, Klinger M, Huang WQ, Wotzlaw C, Hellwig-BĂĽrgel T, Jelkmann W, Acker H, Fandrey J (April 2003). "Intracellular localisation of human HIF-1 alpha hydroxylases: implications for oxygen sensing".
1269:
Epstein AC, Gleadle JM, McNeill LA, Hewitson KS, O'Rourke J, Mole DR, Mukherji M, Metzen E, Wilson MI, Dhanda A, Tian YM, Masson N, Hamilton DL, Jaakkola P, Barstead R, Hodgkin J, Maxwell PH, Pugh CW, Schofield CJ, Ratcliffe PJ (October 2001).
1350:
Oehme F, Ellinghaus P, Kolkhof P, Smith TJ, Ramakrishnan S, HĂĽtter J, Schramm M, Flamme I (August 2002). "Overexpression of PH-4, a novel putative proline 4-hydroxylase, modulates activity of hypoxia-inducible transcription factors".
1211:
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (October 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library".
1418:
Cioffi CL, Liu XQ, Kosinski PA, Garay M, Bowen BR (April 2003). "Differential regulation of HIF-1 alpha prolyl-4-hydroxylase genes by hypoxia in human cardiovascular cells".
257:
156:
1665:"Hypoxia-induced assembly of prolyl hydroxylase PHD3 into complexes: implications for its activity and susceptibility for degradation by the E3 ligase Siah2"
1030:
748:
729:
79:
1921:
2543:
1814:
1182:
Maruyama K, Sugano S (January 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides".
2509:
1989:
1728:
1110:
1092:
2528:
243:
1889:
956:
963:
220:
2163:
1862:
1560:"OS-9 interacts with hypoxia-inducible factor 1alpha and prolyl hydroxylases to promote oxygen-dependent degradation of HIF-1alpha"
1128:
1901:
1847:
1079:
1058:
1593:
Lee S, Nakamura E, Yang H, Wei W, Linggi MS, Sajan MP, Farese RV, Freeman RS, Carter BD, Kaelin WG, Schlisio S (August 2005).
1595:"Neuronal apoptosis linked to EglN3 prolyl hydroxylase and familial pheochromocytoma genes: developmental culling and cancer"
142:
117:
2319:
1075:
2533:
1706:
2434:
1630:"The novel WD-repeat protein Morg1 acts as a molecular scaffold for hypoxia-inducible factor prolyl hydroxylase 3 (PHD3)"
1054:
59:
2130:
1979:
1523:
Masson N, Appelhoff RJ, Tuckerman JR, Tian YM, Demol H, Puype M, Vandekerckhove J, Ratcliffe PJ, Pugh CW (July 2004).
1490:"Differential function of the prolyl hydroxylases PHD1, PHD2, and PHD3 in the regulation of hypoxia-inducible factor"
256:
155:
2502:
1721:
1272:"C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation"
2304:
249:
148:
2420:
2407:
2394:
2381:
2368:
2355:
2342:
2125:
2086:
2076:
2062:
2058:
2048:
2036:
2016:
1999:
1967:
1931:
1831:
1758:
2314:
1558:
Baek JH, Mahon PC, Oh J, Kelly B, Krishnamachary B, Pearson M, Chan DA, Giaccia AJ, Semenza GL (February 2005).
2268:
2211:
1749:
793:
67:
1971:
1447:
Aprelikova O, Chandramouli GV, Wood M, Vasselli JR, Riss J, Maranchie JK, Linehan WM, Barrett JC (June 2004).
2216:
1762:
774:
2110:
2026:
1775:
1488:
Appelhoff RJ, Tian YM, Raval RR, Turley H, Harris AL, Pugh CW, Ratcliffe PJ, Gleadle JM (September 2004).
2495:
2237:
2156:
1906:
1879:
1714:
131:
2309:
1305:
Bruick RK, McKnight SL (November 2001). "A conserved family of prolyl-4-hydroxylases that modify HIF".
2021:
1984:
1745:
1314:
567:
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
46:
2538:
2273:
2007:
914:
863:
2206:
1770:
1476:
1406:
1338:
1240:
Taylor MS (September 2001). "Characterization and comparative analysis of the EGLN gene family".
91:
1916:
939:
918:
888:
867:
1804:
1694:
1651:
1616:
1581:
1546:
1511:
1468:
1435:
1398:
1368:
1330:
1293:
1257:
1228:
1199:
1170:
494:
39:
2479:
2252:
2247:
2221:
2149:
1684:
1676:
1641:
1606:
1571:
1536:
1501:
1460:
1427:
1390:
1360:
1322:
1283:
1249:
1220:
1191:
1160:
336:
267:
211:
166:
87:
2299:
2283:
2196:
1894:
311:
1318:
2448:
2337:
2278:
2120:
2100:
2095:
1737:
1689:
1664:
1431:
1364:
1288:
1271:
1253:
1224:
1165:
1148:
663:
658:
653:
648:
643:
638:
633:
628:
623:
607:
602:
597:
592:
576:
571:
566:
561:
556:
551:
546:
541:
536:
2522:
2475:
2242:
2201:
1195:
523:
1480:
1410:
71:
2191:
1939:
1935:
1342:
329:
108:
1541:
1524:
649:
regulation of transcription from RNA polymerase II promoter in response to hypoxia
1576:
1559:
1525:"The HIF prolyl hydroxylase PHD3 is a potential substrate of the TRiC chaperonin"
95:
2415:
2350:
2186:
1115:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1097:
National Center for
Biotechnology Information, U.S. National Library of Medicine
654:
activation of cysteine-type endopeptidase activity involved in apoptotic process
2443:
412:
2071:
1611:
1594:
228:
125:
75:
1149:"HIF-1, O(2), and the 3 PHDs: how animal cells signal hypoxia to the nucleus"
2389:
2363:
2040:
2003:
1947:
1741:
1326:
693:
472:
350:
295:
282:
194:
181:
83:
1698:
1655:
1646:
1629:
1620:
1585:
1550:
1515:
1506:
1489:
1472:
1439:
1402:
1372:
1334:
1297:
1261:
1174:
1232:
1203:
1003:
998:
1819:
987:
838:
819:
2115:
1680:
1019:
805:
760:
1464:
1394:
2402:
2172:
1957:
1952:
1911:
971:
715:
2463:
1449:"Regulation of HIF prolyl hydroxylases by hypoxia-inducible factors"
1448:
2376:
2104:
1839:
1797:
1785:
1780:
1663:
Nakayama K, Gazdoiu S, Abraham R, Pan ZQ, Ronai Z (January 2007).
678:
674:
503:
2471:
1884:
1872:
1867:
1857:
1852:
1835:
1809:
1628:
Hopfer U, Hopfer H, Jablonski K, Stahl RA, Wolf G (March 2006).
1026:
63:
50:, HIFP4H3, HIFPH3, PHD3, egl-9 family hypoxia inducible factor 3
2145:
1710:
2141:
319:
2483:
2432:
634:
peptidyl-proline hydroxylation to 4-hydroxy-L-proline
484:
1129:"Entrez Gene: EGLN3 egl nine homolog 3 (C. elegans)"
2328:
2292:
2261:
2230:
2179:
2085:
2057:
2035:
1998:
1966:
1930:
1830:
1757:
1420:
1353:
932:
907:
881:
856:
1071:
1069:
1067:
1050:
1048:
1046:
266:
165:
1033:, which are non-haem iron-containing proteins.
18:Protein-coding gene in the species Homo sapiens
1076:GRCm38: Ensembl release 89: ENSMUSG00000035105
2503:
2157:
1722:
537:2-oxoglutarate-dependent dioxygenase activity
8:
1055:GRCh38: Ensembl release 89: ENSG00000129521
644:regulation of cell population proliferation
2510:
2496:
2164:
2150:
2142:
1729:
1715:
1707:
1031:alpha-ketoglutarate-dependent hydroxylases
1029:. ELGN3 is a member of the superfamily of
689:
519:
307:
206:
103:
1688:
1645:
1610:
1575:
1540:
1505:
1287:
1164:
639:cellular response to DNA damage stimulus
2439:
1042:
577:peptidyl-proline 4-dioxygenase activity
629:regulation of neuron apoptotic process
20:
271:
232:
227:
170:
129:
124:
7:
2460:
2458:
1922:24-hydroxycholesterol 7α-hydroxylase
1634:The Journal of Biological Chemistry
1494:The Journal of Biological Chemistry
2482:. You can help Knowledge (XXG) by
929:
904:
878:
853:
829:
810:
784:
765:
739:
720:
489:
407:
345:
324:
14:
1022:that in humans is encoded by the
2462:
2442:
1453:Journal of Cellular Biochemistry
493:
255:
248:
242:
219:
154:
147:
141:
116:
1902:Cholesterol 7 alpha-hydroxylase
1848:Flavin-containing monooxygenase
2544:Human chromosome 14 gene stubs
504:More reference expression data
473:More reference expression data
1:
1542:10.1016/j.febslet.2004.06.040
1432:10.1016/S0006-291X(03)00453-4
1365:10.1016/S0006-291X(02)00862-8
1289:10.1016/S0092-8674(01)00507-4
1254:10.1016/S0378-1119(01)00633-3
1225:10.1016/S0378-1119(97)00411-3
1166:10.1016/S0092-8674(01)00518-9
447:epithelium of small intestine
240:
139:
2529:Genes on human chromosome 14
1577:10.1016/j.molcel.2005.01.011
1196:10.1016/0378-1119(94)90802-8
2131:Deoxyhypusine monooxygenase
1147:Semenza GL (October 2001).
2560:
2457:
459:sternocleidomastoid muscle
2320:Michaelis–Menten kinetics
2126:Ecdysone 20-monooxygenase
2077:Stearoyl-CoA desaturase-1
2049:Dopamine beta-hydroxylase
2017:Phenylalanine hydroxylase
1612:10.1016/j.ccr.2005.06.015
1111:"Mouse PubMed Reference:"
1093:"Human PubMed Reference:"
1002:
997:
993:
986:
970:
951:
936:
911:
900:
885:
860:
849:
836:
832:
817:
813:
804:
791:
787:
772:
768:
759:
746:
742:
727:
723:
714:
699:
692:
688:
672:
522:
518:
501:
492:
483:
470:
419:
410:
357:
348:
318:
310:
306:
289:
276:
239:
218:
209:
205:
188:
175:
138:
115:
106:
102:
57:
54:
44:
37:
32:
28:
23:
2212:Diffusion-limited enzyme
964:Chr 12: 54.23 – 54.25 Mb
957:Chr 14: 33.92 – 34.46 Mb
1669:The Biochemical Journal
1383:Journal of Cell Science
1327:10.1126/science.1066373
572:oxidoreductase activity
547:L-ascorbic acid binding
2111:Squalene monooxygenase
2027:Tryptophan hydroxylase
1776:HIF prolyl-hydroxylase
1647:10.1074/jbc.M513751200
1507:10.1074/jbc.M406026200
435:mucous cell of stomach
2305:Eadie–Hofstee diagram
2238:Allosteric regulation
1907:Methane monooxygenase
1880:Nitric oxide synthase
659:protein hydroxylation
451:epithelium of stomach
234:Chromosome 12 (mouse)
132:Chromosome 14 (human)
2534:Human 2OG oxygenases
2315:Lineweaver–Burk plot
2022:Tyrosine hydroxylase
1746:steroid hydroxylases
552:dioxygenase activity
1972:iron–sulfur protein
1319:2001Sci...294.1337B
624:response to hypoxia
439:conjunctival fornix
2470:This article on a
2274:Enzyme superfamily
2207:Enzyme promiscuity
1771:Prolyl hydroxylase
1681:10.1042/BJ20061135
1016:Egl nine homolog 3
794:ENSMUSG00000035105
617:Biological process
586:Cellular component
530:Molecular function
385:right uterine tube
2491:
2490:
2430:
2429:
2139:
2138:
1805:Lysyl hydroxylase
1465:10.1002/jcb.20067
1395:10.1242/jcs.00318
1389:(Pt 7): 1319–26.
1313:(5545): 1337–40.
1013:
1012:
1009:
1008:
982:
981:
947:
946:
926:
925:
896:
895:
875:
874:
845:
844:
826:
825:
800:
799:
781:
780:
755:
754:
736:
735:
684:
683:
664:apoptotic process
557:metal ion binding
514:
513:
510:
509:
479:
478:
466:
465:
404:
403:
302:
301:
201:
200:
96:EGLN3 - orthologs
2551:
2512:
2505:
2498:
2466:
2459:
2447:
2446:
2438:
2310:Hanes–Woolf plot
2253:Enzyme activator
2248:Enzyme inhibitor
2222:Enzyme catalysis
2166:
2159:
2152:
2143:
1731:
1724:
1717:
1708:
1702:
1692:
1659:
1649:
1624:
1614:
1589:
1579:
1554:
1544:
1519:
1509:
1500:(37): 38458–65.
1484:
1443:
1414:
1376:
1346:
1301:
1291:
1265:
1236:
1207:
1178:
1168:
1133:
1132:
1125:
1119:
1118:
1107:
1101:
1100:
1089:
1083:
1073:
1062:
1052:
995:
994:
966:
959:
942:
930:
921:
905:
901:RefSeq (protein)
891:
879:
870:
854:
830:
811:
785:
766:
740:
721:
690:
542:iron ion binding
520:
506:
497:
490:
475:
443:digastric muscle
415:
413:Top expressed in
408:
381:ventricular zone
353:
351:Top expressed in
346:
325:
308:
298:
285:
274:
259:
252:
246:
235:
223:
207:
197:
184:
173:
158:
151:
145:
134:
120:
104:
98:
49:
42:
21:
2559:
2558:
2554:
2553:
2552:
2550:
2549:
2548:
2519:
2518:
2517:
2516:
2455:
2453:
2441:
2433:
2431:
2426:
2338:Oxidoreductases
2324:
2300:Enzyme kinetics
2288:
2284:List of enzymes
2257:
2226:
2197:Catalytic triad
2175:
2170:
2140:
2135:
2089:- miscellaneous
2081:
2053:
2031:
1994:
1962:
1926:
1917:14α-demethylase
1826:
1753:
1738:Oxidoreductases
1735:
1705:
1662:
1640:(13): 8645–55.
1627:
1592:
1557:
1535:(1–3): 166–70.
1522:
1487:
1446:
1417:
1379:
1349:
1304:
1268:
1239:
1219:(1–2): 149–56.
1210:
1181:
1146:
1142:
1140:Further reading
1137:
1136:
1127:
1126:
1122:
1109:
1108:
1104:
1091:
1090:
1086:
1074:
1065:
1053:
1044:
1039:
1004:View/Edit Mouse
999:View/Edit Human
962:
955:
952:Location (UCSC)
938:
917:
913:
887:
866:
862:
775:ENSG00000129521
668:
612:
581:
562:protein binding
502:
471:
462:
457:
453:
449:
445:
441:
437:
433:
429:
427:masseter muscle
425:
423:temporal muscle
411:
400:
395:
391:
387:
383:
379:
375:
371:
367:
365:skin of abdomen
363:
349:
293:
280:
272:
262:
261:
260:
253:
233:
210:Gene location (
192:
179:
171:
161:
160:
159:
152:
130:
107:Gene location (
58:
45:
38:
19:
12:
11:
5:
2557:
2555:
2547:
2546:
2541:
2536:
2531:
2521:
2520:
2515:
2514:
2507:
2500:
2492:
2489:
2488:
2467:
2452:
2451:
2428:
2427:
2425:
2424:
2411:
2398:
2385:
2372:
2359:
2346:
2332:
2330:
2326:
2325:
2323:
2322:
2317:
2312:
2307:
2302:
2296:
2294:
2290:
2289:
2287:
2286:
2281:
2276:
2271:
2265:
2263:
2262:Classification
2259:
2258:
2256:
2255:
2250:
2245:
2240:
2234:
2232:
2228:
2227:
2225:
2224:
2219:
2214:
2209:
2204:
2199:
2194:
2189:
2183:
2181:
2177:
2176:
2171:
2169:
2168:
2161:
2154:
2146:
2137:
2136:
2134:
2133:
2128:
2123:
2118:
2113:
2108:
2101:Heme oxygenase
2098:
2096:Cyclooxygenase
2092:
2090:
2083:
2082:
2080:
2079:
2074:
2068:
2066:
2055:
2054:
2052:
2051:
2045:
2043:
2033:
2032:
2030:
2029:
2024:
2019:
2013:
2011:
1996:
1995:
1993:
1992:
1987:
1982:
1976:
1974:
1964:
1963:
1961:
1960:
1955:
1950:
1944:
1942:
1928:
1927:
1925:
1924:
1919:
1914:
1909:
1904:
1899:
1898:
1897:
1892:
1887:
1877:
1876:
1875:
1870:
1865:
1860:
1855:
1844:
1842:
1828:
1827:
1825:
1824:
1823:
1822:
1817:
1807:
1802:
1801:
1800:
1795:
1794:
1793:
1788:
1783:
1767:
1765:
1763:2-oxoglutarate
1755:
1754:
1736:
1734:
1733:
1726:
1719:
1711:
1704:
1703:
1660:
1625:
1590:
1564:Molecular Cell
1555:
1520:
1485:
1459:(3): 491–501.
1444:
1415:
1377:
1347:
1302:
1266:
1237:
1208:
1190:(1–2): 171–4.
1179:
1143:
1141:
1138:
1135:
1134:
1120:
1102:
1084:
1063:
1041:
1040:
1038:
1035:
1011:
1010:
1007:
1006:
1001:
991:
990:
984:
983:
980:
979:
977:
975:
968:
967:
960:
953:
949:
948:
945:
944:
934:
933:
927:
924:
923:
909:
908:
902:
898:
897:
894:
893:
883:
882:
876:
873:
872:
858:
857:
851:
847:
846:
843:
842:
834:
833:
827:
824:
823:
815:
814:
808:
802:
801:
798:
797:
789:
788:
782:
779:
778:
770:
769:
763:
757:
756:
753:
752:
744:
743:
737:
734:
733:
725:
724:
718:
712:
711:
706:
701:
697:
696:
686:
685:
682:
681:
670:
669:
667:
666:
661:
656:
651:
646:
641:
636:
631:
626:
620:
618:
614:
613:
611:
610:
605:
600:
595:
589:
587:
583:
582:
580:
579:
574:
569:
564:
559:
554:
549:
544:
539:
533:
531:
527:
526:
516:
515:
512:
511:
508:
507:
499:
498:
487:
481:
480:
477:
476:
468:
467:
464:
463:
461:
460:
456:
455:pyloric antrum
452:
448:
444:
440:
436:
432:
428:
424:
420:
417:
416:
405:
402:
401:
399:
398:
394:
390:
386:
382:
378:
374:
373:left ventricle
370:
366:
362:
358:
355:
354:
342:
341:
333:
322:
316:
315:
312:RNA expression
304:
303:
300:
299:
291:
287:
286:
278:
275:
270:
264:
263:
254:
247:
241:
237:
236:
231:
225:
224:
216:
215:
203:
202:
199:
198:
190:
186:
185:
177:
174:
169:
163:
162:
153:
146:
140:
136:
135:
128:
122:
121:
113:
112:
100:
99:
56:
52:
51:
43:
35:
34:
30:
29:
26:
25:
17:
13:
10:
9:
6:
4:
3:
2:
2556:
2545:
2542:
2540:
2537:
2535:
2532:
2530:
2527:
2526:
2524:
2513:
2508:
2506:
2501:
2499:
2494:
2493:
2487:
2485:
2481:
2477:
2476:chromosome 14
2473:
2468:
2465:
2461:
2456:
2450:
2445:
2440:
2436:
2422:
2418:
2417:
2412:
2409:
2405:
2404:
2399:
2396:
2392:
2391:
2386:
2383:
2379:
2378:
2373:
2370:
2366:
2365:
2360:
2357:
2353:
2352:
2347:
2344:
2340:
2339:
2334:
2333:
2331:
2327:
2321:
2318:
2316:
2313:
2311:
2308:
2306:
2303:
2301:
2298:
2297:
2295:
2291:
2285:
2282:
2280:
2279:Enzyme family
2277:
2275:
2272:
2270:
2267:
2266:
2264:
2260:
2254:
2251:
2249:
2246:
2244:
2243:Cooperativity
2241:
2239:
2236:
2235:
2233:
2229:
2223:
2220:
2218:
2215:
2213:
2210:
2208:
2205:
2203:
2202:Oxyanion hole
2200:
2198:
2195:
2193:
2190:
2188:
2185:
2184:
2182:
2178:
2174:
2167:
2162:
2160:
2155:
2153:
2148:
2147:
2144:
2132:
2129:
2127:
2124:
2122:
2119:
2117:
2114:
2112:
2109:
2106:
2102:
2099:
2097:
2094:
2093:
2091:
2088:
2084:
2078:
2075:
2073:
2070:
2069:
2067:
2064:
2060:
2056:
2050:
2047:
2046:
2044:
2042:
2038:
2034:
2028:
2025:
2023:
2020:
2018:
2015:
2014:
2012:
2009:
2008:BH4 dependent
2005:
2001:
1997:
1991:
1988:
1986:
1983:
1981:
1978:
1977:
1975:
1973:
1969:
1965:
1959:
1956:
1954:
1951:
1949:
1946:
1945:
1943:
1941:
1937:
1933:
1929:
1923:
1920:
1918:
1915:
1913:
1910:
1908:
1905:
1903:
1900:
1896:
1893:
1891:
1888:
1886:
1883:
1882:
1881:
1878:
1874:
1871:
1869:
1866:
1864:
1861:
1859:
1856:
1854:
1851:
1850:
1849:
1846:
1845:
1843:
1841:
1837:
1833:
1829:
1821:
1818:
1816:
1813:
1812:
1811:
1808:
1806:
1803:
1799:
1796:
1792:
1789:
1787:
1784:
1782:
1779:
1778:
1777:
1774:
1773:
1772:
1769:
1768:
1766:
1764:
1760:
1756:
1751:
1747:
1743:
1739:
1732:
1727:
1725:
1720:
1718:
1713:
1712:
1709:
1700:
1696:
1691:
1686:
1682:
1678:
1675:(1): 217–26.
1674:
1670:
1666:
1661:
1657:
1653:
1648:
1643:
1639:
1635:
1631:
1626:
1622:
1618:
1613:
1608:
1605:(2): 155–67.
1604:
1600:
1596:
1591:
1587:
1583:
1578:
1573:
1570:(4): 503–12.
1569:
1565:
1561:
1556:
1552:
1548:
1543:
1538:
1534:
1530:
1526:
1521:
1517:
1513:
1508:
1503:
1499:
1495:
1491:
1486:
1482:
1478:
1474:
1470:
1466:
1462:
1458:
1454:
1450:
1445:
1441:
1437:
1433:
1429:
1426:(3): 947–53.
1425:
1421:
1416:
1412:
1408:
1404:
1400:
1396:
1392:
1388:
1384:
1378:
1374:
1370:
1366:
1362:
1358:
1354:
1348:
1344:
1340:
1336:
1332:
1328:
1324:
1320:
1316:
1312:
1308:
1303:
1299:
1295:
1290:
1285:
1281:
1277:
1273:
1267:
1263:
1259:
1255:
1251:
1248:(1): 125–32.
1247:
1243:
1238:
1234:
1230:
1226:
1222:
1218:
1214:
1209:
1205:
1201:
1197:
1193:
1189:
1185:
1180:
1176:
1172:
1167:
1162:
1158:
1154:
1150:
1145:
1144:
1139:
1130:
1124:
1121:
1116:
1112:
1106:
1103:
1098:
1094:
1088:
1085:
1081:
1077:
1072:
1070:
1068:
1064:
1060:
1056:
1051:
1049:
1047:
1043:
1036:
1034:
1032:
1028:
1025:
1021:
1017:
1005:
1000:
996:
992:
989:
985:
978:
976:
973:
969:
965:
961:
958:
954:
950:
943:
941:
935:
931:
928:
922:
920:
916:
910:
906:
903:
899:
892:
890:
884:
880:
877:
871:
869:
865:
859:
855:
852:
850:RefSeq (mRNA)
848:
841:
840:
835:
831:
828:
822:
821:
816:
812:
809:
807:
803:
796:
795:
790:
786:
783:
777:
776:
771:
767:
764:
762:
758:
751:
750:
745:
741:
738:
732:
731:
726:
722:
719:
717:
713:
710:
707:
705:
702:
698:
695:
691:
687:
680:
676:
671:
665:
662:
660:
657:
655:
652:
650:
647:
645:
642:
640:
637:
635:
632:
630:
627:
625:
622:
621:
619:
616:
615:
609:
606:
604:
601:
599:
596:
594:
591:
590:
588:
585:
584:
578:
575:
573:
570:
568:
565:
563:
560:
558:
555:
553:
550:
548:
545:
543:
540:
538:
535:
534:
532:
529:
528:
525:
524:Gene ontology
521:
517:
505:
500:
496:
491:
488:
486:
482:
474:
469:
458:
454:
450:
446:
442:
438:
434:
430:
426:
422:
421:
418:
414:
409:
406:
396:
392:
388:
384:
380:
377:right auricle
376:
372:
369:apex of heart
368:
364:
360:
359:
356:
352:
347:
344:
343:
340:
338:
334:
332:
331:
327:
326:
323:
321:
317:
313:
309:
305:
297:
292:
288:
284:
279:
273:12|12 C1
269:
265:
258:
251:
245:
238:
230:
226:
222:
217:
213:
208:
204:
196:
191:
187:
183:
178:
168:
164:
157:
150:
144:
137:
133:
127:
123:
119:
114:
110:
105:
101:
97:
93:
89:
85:
81:
77:
73:
69:
65:
61:
53:
48:
41:
36:
31:
27:
22:
16:
2484:expanding it
2469:
2454:
2416:Translocases
2413:
2400:
2387:
2374:
2361:
2351:Transferases
2348:
2335:
2192:Binding site
1940:flavoprotein
1790:
1744:, including
1742:dioxygenases
1672:
1668:
1637:
1633:
1602:
1598:
1567:
1563:
1532:
1529:FEBS Letters
1528:
1497:
1493:
1456:
1452:
1423:
1419:
1386:
1382:
1359:(2): 343–9.
1356:
1352:
1310:
1306:
1282:(1): 43–54.
1279:
1275:
1245:
1241:
1216:
1212:
1187:
1183:
1156:
1152:
1123:
1114:
1105:
1096:
1087:
1023:
1015:
1014:
937:
915:NP_001295032
912:
886:
864:NM_001308103
861:
837:
818:
792:
773:
747:
728:
708:
703:
335:
328:
55:External IDs
15:
2187:Active site
1599:Cancer Cell
593:nucleoplasm
361:skin of leg
294:54,250,646
281:54,225,767
193:34,462,774
180:33,924,227
33:Identifiers
2539:EC 1.14.11
2523:Categories
2390:Isomerases
2364:Hydrolases
2231:Regulation
2072:Tyrosinase
2039:: reduced
2002:: reduced
1970:: reduced
1934:: reduced
1159:(1): 1–3.
1082:, May 2017
1061:, May 2017
1037:References
393:C1 segment
339:(ortholog)
76:HomoloGene
2474:on human
2269:EC number
2041:ascorbate
2004:pteridine
940:NP_082409
919:NP_071356
889:NM_028133
868:NM_022073
694:Orthologs
603:cytoplasm
431:esophagus
84:GeneCards
2293:Kinetics
2217:Cofactor
2180:Activity
1699:16958618
1656:16407229
1621:16098468
1586:15721254
1551:15251459
1516:15247232
1481:24455956
1473:15156561
1440:12670503
1411:13698068
1403:12615973
1373:12163023
1335:11598268
1298:11595184
1262:11574160
1175:11595178
1078:–
1057:–
988:Wikidata
673:Sources:
397:amygdala
2449:Biology
2403:Ligases
2173:Enzymes
2087:1.14.99
2065:: other
2059:1.14.18
2037:1.14.17
2000:1.14.16
1968:1.14.15
1932:1.14.14
1832:1.14.13
1759:1.14.11
1690:1698661
1343:9695199
1315:Bibcode
1307:Science
1233:9373149
1204:8125298
1080:Ensembl
1059:Ensembl
1020:protein
806:UniProt
761:Ensembl
700:Species
679:QuickGO
608:cytosol
598:nucleus
314:pattern
172:14q13.1
72:1932288
40:Aliases
2435:Portal
2377:Lyases
1936:flavin
1815:ALKBH1
1697:
1687:
1654:
1619:
1584:
1549:
1514:
1479:
1471:
1438:
1409:
1401:
1371:
1341:
1333:
1296:
1260:
1231:
1202:
1173:
974:search
972:PubMed
839:Q91UZ4
820:Q9H6Z9
749:112407
730:112399
716:Entrez
485:BioGPS
389:rectum
64:606426
2478:is a
2329:Types
2105:HMOX1
1840:NADPH
1798:P4HTM
1791:EGLN3
1786:EGLN2
1781:EGLN1
1752:1.14)
1477:S2CID
1407:S2CID
1339:S2CID
1024:EGLN3
1018:is a
709:Mouse
704:Human
675:Amigo
337:Mouse
330:Human
277:Start
212:Mouse
176:Start
109:Human
88:EGLN3
80:32531
47:EGLN3
24:EGLN3
2480:stub
2472:gene
2421:list
2414:EC7
2408:list
2401:EC6
2395:list
2388:EC5
2382:list
2375:EC4
2369:list
2362:EC3
2356:list
2349:EC2
2343:list
2336:EC1
2121:21A2
2116:17A1
1990:11A1
1985:11B2
1980:11B1
1948:19A1
1895:NOS3
1890:NOS2
1885:NOS1
1873:FMO5
1868:FMO4
1863:FMO3
1858:FMO2
1853:FMO1
1836:NADH
1810:AlkB
1695:PMID
1652:PMID
1617:PMID
1582:PMID
1547:PMID
1512:PMID
1469:PMID
1436:PMID
1399:PMID
1369:PMID
1331:PMID
1294:PMID
1276:Cell
1258:PMID
1242:Gene
1229:PMID
1213:Gene
1200:PMID
1184:Gene
1171:PMID
1153:Cell
1027:gene
320:Bgee
268:Band
229:Chr.
167:Band
126:Chr.
60:OMIM
1958:2E1
1953:2D6
1938:or
1912:3A4
1838:or
1820:FTO
1685:PMC
1677:doi
1673:401
1642:doi
1638:281
1607:doi
1572:doi
1537:doi
1533:570
1502:doi
1498:279
1461:doi
1428:doi
1424:303
1391:doi
1387:116
1361:doi
1357:296
1323:doi
1311:294
1284:doi
1280:107
1250:doi
1246:275
1221:doi
1217:200
1192:doi
1188:138
1161:doi
1157:107
290:End
189:End
92:OMA
68:MGI
2525::
2063:19
1834::
1761::
1750:EC
1740::
1693:.
1683:.
1671:.
1667:.
1650:.
1636:.
1632:.
1615:.
1601:.
1597:.
1580:.
1568:17
1566:.
1562:.
1545:.
1531:.
1527:.
1510:.
1496:.
1492:.
1475:.
1467:.
1457:92
1455:.
1451:.
1434:.
1422:.
1405:.
1397:.
1385:.
1367:.
1355:.
1337:.
1329:.
1321:.
1309:.
1292:.
1278:.
1274:.
1256:.
1244:.
1227:.
1215:.
1198:.
1186:.
1169:.
1155:.
1151:.
1113:.
1095:.
1066:^
1045:^
677:/
296:bp
283:bp
195:bp
182:bp
90:;
86::
82:;
78::
74:;
70::
66:;
62::
2511:e
2504:t
2497:v
2486:.
2437::
2423:)
2419:(
2410:)
2406:(
2397:)
2393:(
2384:)
2380:(
2371:)
2367:(
2358:)
2354:(
2345:)
2341:(
2165:e
2158:t
2151:v
2107:)
2103:(
2061:-
2010:)
2006:(
1748:(
1730:e
1723:t
1716:v
1701:.
1679::
1658:.
1644::
1623:.
1609::
1603:8
1588:.
1574::
1553:.
1539::
1518:.
1504::
1483:.
1463::
1442:.
1430::
1413:.
1393::
1375:.
1363::
1345:.
1325::
1317::
1300:.
1286::
1264:.
1252::
1235:.
1223::
1206:.
1194::
1177:.
1163::
1131:.
1117:.
1099:.
214:)
111:)
94::
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