47:
847:
569:
324:
Southern is also the founder and chairman of Oxford Gene
Technology. He is also the founder (in 2000) and chairman of a Scottish charity, The Kirkhouse Trust, which aims to promote education and research in the Natural Sciences, particularly the biological and medical sciences, and the Edina Trust,
349:
prior to the development of microsatellite markers for this purpose. The procedure is also frequently used to determine the number of copies of a gene in the genome. The concepts of the
Southern blot were used in the development and creation of the modern microarray slide, which is an extensively
1199:
1603:
1558:
1203:
470:
fraction, demonstrating that a guinea pig 'satellite' had an unexpectedly simple repetitive structure based on a sequence of six nucleotides. In mouse satellite DNA he showed both short and long range
485:
DNA may have evolved. Southern has devised valuable methods for DNA analysis. His 'blot' technique, for the identification of specific sequences among large populations of fragments generated by
1252:
960:
1553:
1608:
427:
135:
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806:"Oligonucleotide hybridisations on glass supports: A novel linker for oligonucleotide synthesis and hybridisation properties of oligonucleotides synthesised in situ"
1613:
1156:
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1598:
1083:
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36:
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776:
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he showed both short and long range periodicities. These and other studies on repetitive DNA sequences enabled him to suggest how
371:
326:
585:
522:
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in chromosomes. Apart from studies on crab poly-AT carried out in the early 1960s, Southern was the first to determine the
223:
46:
1338:
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1053:
489:, has found extremely widespread and important applications. He has also made important observations on the differential
1593:
1583:
1578:
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1244:
260:
32:
442:
Award for outstanding contributions to
Biomolecular Technologies. In 2012, he was elected an Honorary Fellow of the
1365:
1313:
443:
1027:
325:
which was founded to promote science in schools. These charities are financed using royalty income from licensing
1573:
312:(BSc Hons., 1958). He continued as a graduate student (then Demonstrator, 1963) in the Department of Chemistry,
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309:
90:
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174:
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1360:
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920:
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313:
96:
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1509:
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1400:
1286:
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1130:
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308:. He has a brother named John Southern and a sister Kay Monie. He went on to read Chemistry at the
301:
1481:
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661:(1975). "Detection of specific sequences among DNA fragments separated by gel electrophoresis".
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1503:
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864:(1997). "Selecting effective antisense reagents on combinatorial oligonucleotide arrays".
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1175:"Professor Sir Edwin Mellor Southern FRS HonFRSE - The Royal Society of Edinburgh"
592:
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924:
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Southern founded Oxford Gene
Technology (OGT) in 1995, a company that developed
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1515:
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463:
459:
391:
916:
553:
1390:
821:
519:"Professor Sir Edwin Southern – Founder, Chairman and Chief Science Advisor"
1061:
1005:
707:; Mir, K.; Shchepinov, M. (1999). "Molecular interactions on microarrays".
636:
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885:
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728:
682:
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for his invention of the
Southern blot. In 2005 he was also awarded the
1031:
937:
367:
77:
545:
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in the June 2003 Birthday
Honours for services to the development of
418:
Award for
Excellence in Molecular Diagnostics in 1999. He was made a
187:
538:
Construction and analysis of vectors based on bovine papilloma virus
557:
1109:"2005 Albert Lasker Award – Acceptance remarks by Edwin Southern"
720:
1604:
Recipients of the Lasker–DeBakey
Clinical Medical Research Award
1217:
909:
Studies on synthetic and naturally occurring enzyme metabolites
345:
analysis and was routinely used for genetic fingerprinting and
194:
Studies on synthetic and naturally occurring enzyme metabolites
467:
363:
342:
454:
Dr. Southern has done pioneering work on the organization of
374:
of proteins, respectively, are all puns on
Southern's name.
292:, published in 1975 and now a common laboratory procedure.
756:"[9] Gel electrophoresis of restriction fragments"
763:. Methods in Enzymology. Vol. 68. pp. 152–176.
1127:"2005 Albert Lasker Award for Clinical Medical Research"
394:
based on his patent holdings in microarray technology.
1559:
Members of the
European Molecular Biology Organization
426:
technologies. In 2005 he was awarded the prestigious
1495:
1474:
1259:
288:. He is most widely known for the invention of the
218:
204:
186:
162:
152:
116:
106:
85:
56:
23:
754:
980:"Sir Edwin Southern: Scientist as problem solver"
607:
605:
428:Albert Lasker Award for Clinical Medical Research
402:In 1990, Southern was one of the winners of the
1157:Association of Biomolecular Resource Facilities
452:
440:Association of Biomolecular Resource Facilities
493:of DNA sequences into RNA, and on patterns of
1229:
8:
761:Gel electrophoresis of restriction fragments
513:
511:
1202:. London: The Royal Society. Archived from
1236:
1222:
1214:
20:
1554:People educated at Burnley Grammar School
1030:. The Gairdner Foundation. Archived from
995:
829:
362:, related procedures for the analysis of
1609:Academics of the University of Edinburgh
521:. Oxford Gene Technology. Archived from
316:, where he was awarded his PhD in 1962.
540:(PhD thesis). University of Edinburgh.
507:
404:Gairdner Foundation International Award
1614:Alumni of the University of Manchester
911:(PhD thesis). University of Glasgow.
7:
1200:"EC/1983/34: Southern, Edwin Mellor"
580:
578:
1129:. Lasker Foundation. Archived from
1111:. Lasker Foundation. Archived from
1088:Association for Molecular Pathology
416:Association for Molecular Pathology
1599:Whitley Professors of Biochemistry
14:
536:Allshire, Robin Campbell (1985).
280:Professor of Biochemistry at the
268:(born 7 June 1938) is an English
845:
567:
45:
907:Southern, Edwin Mellor (1964).
372:post-translational modification
1179:The Royal Society of Edinburgh
615:(2005). "Tools for genomics".
1:
1282:Sivaramakrishna Chandrasekhar
997:10.1016/S0140-6736(05)67775-6
675:10.1016/S0022-2836(75)80083-0
474:. These and other studies on
406:. In 1998 he was awarded the
1589:Fellows of the Royal Society
1569:British molecular biologists
769:10.1016/0076-6879(79)68011-4
663:Journal of Molecular Biology
350:used experimental tool. The
386:technology. OGT won a 1999
16:English molecular biologist
1630:
1314:William Alexander Gambling
444:Royal Society of Edinburgh
446:. His nomination for the
257:Sir Edwin Mellor Southern
214:
145:
44:
961:"Glossary:Southern blot"
860:Milner, N.; Mir, K. U.;
310:University of Manchester
296:Early life and education
91:University of Manchester
591:. Roche. Archived from
436:University of Leicester
412:Royal Society of London
286:Trinity College, Oxford
175:University of Edinburgh
1304:Malcolm Ferguson-Smith
1054:"Royal recent winners"
810:Nucleic Acids Research
499:
306:Burnley Grammar School
179:Oxford Gene Technology
1528:Frank Westheimer
822:10.1093/nar/20.7.1679
314:University of Glasgow
300:Southern was born in
97:University of Glasgow
61:Edwin Mellor Southern
1510:G. Evelyn Hutchinson
1504:Anatole Abragam
1401:Michael J. D. Powell
1287:Pierre Deslongchamps
1163:on 22 November 2007.
978:Harding, A. (2005).
866:Nature Biotechnology
282:University of Oxford
170:University of Oxford
1594:People from Burnley
1584:Royal Medal winners
1579:British biochemists
1133:on 11 December 2007
1064:on 19 December 2007
1034:on 30 December 2007
878:10.1038/nbt0697-537
629:10.1038/nm1005-1029
586:"Edwin Southern CV"
388:patent infringement
320:Career and Research
302:Burnley, Lancashire
274:molecular biologist
1522:Henry Stommel
1482:David Attenborough
1349:Christopher Hooley
562:uk.bl.ethos.355979
414:. He received the
398:Awards and honours
1536:
1535:
1487:Margaret Thatcher
1456:Charles Weissmann
1339:Richard Henderson
1084:"Past Recipients"
1058:The Royal Society
1028:"List of winners"
623:(10): 1029–1034.
525:on 17 April 2015.
347:paternity testing
254:
253:
205:Doctoral students
157:Molecular Biology
147:Scientific career
51:Sir Edwin in 2012
1621:
1574:Knights Bachelor
1238:
1231:
1224:
1215:
1208:
1207:
1206:on 13 July 2015.
1196:
1190:
1189:
1187:
1185:
1171:
1165:
1164:
1159:. Archived from
1149:
1143:
1142:
1140:
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1117:
1116:
1115:on 10 June 2008.
1105:
1099:
1098:
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1080:
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1073:
1071:
1069:
1060:. Archived from
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1024:
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999:
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850:
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843:
833:
816:(7): 1679–1684.
797:
791:
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758:
747:
741:
740:
715:(1 Suppl): 5–9.
701:
695:
694:
655:
649:
648:
609:
600:
599:
598:on 2 April 2012.
597:
590:
582:
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527:
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390:lawsuit against
304:and educated at
284:and a fellow of
267:
250:
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80:, United Kingdom
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49:
39:
21:
1629:
1628:
1624:
1623:
1622:
1620:
1619:
1618:
1539:
1538:
1537:
1532:
1516:Jean Leray
1491:
1470:
1466:Dudley Williams
1376:C David Marsden
1319:Ian Graham Gass
1293:William Douglas
1272:Patrick Bateson
1255:
1242:
1212:
1211:
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1193:
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1035:
1026:
1025:
1021:
977:
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972:
959:
958:
954:
947:
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938:Kirkhouse Trust
936:
932:
906:
905:
901:
862:Southern, E. M.
859:
858:
854:
844:
802:Southern, E. M.
799:
798:
794:
779:
749:
748:
744:
709:Nature Genetics
703:
702:
698:
659:Southern, E. M.
657:
656:
652:
617:Nature Medicine
611:
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603:
595:
588:
584:
583:
576:
566:
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517:
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509:
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495:DNA methylation
430:, jointly with
420:Knight Bachelor
400:
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335:
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259:
222:
198:
182:
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102:
86:Alma mater
81:
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52:
40:
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29:
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12:
11:
5:
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1471:
1469:
1468:
1463:
1458:
1453:
1451:Felix Weinberg
1448:
1443:
1438:
1436:Brian Spalding
1433:
1431:Edwin Southern
1428:
1423:
1418:
1413:
1408:
1403:
1398:
1396:Michael Pepper
1393:
1388:
1383:
1381:Donald Metcalf
1378:
1373:
1371:George Lusztig
1368:
1363:
1361:Peter Lawrence
1358:
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1336:
1331:
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1277:Edward Cocking
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990:(9501): 1919.
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930:
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872:(6): 537–541.
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792:
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742:
696:
669:(3): 503–517.
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601:
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476:repetitive DNA
462:sequence of a
424:DNA microarray
399:
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384:DNA microarray
379:
378:DNA microarray
376:
334:
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209:Robin Allshire
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124:Gairdner award
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107:Known for
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100:
89:
87:
83:
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60:
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54:
53:
50:
42:
41:
30:
28:Edwin Southern
27:
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15:
13:
10:
9:
6:
4:
3:
2:
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1564:Living people
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1461:John Westcott
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1421:Dennis Sciama
1419:
1417:
1416:Alan Sargeson
1414:
1412:
1409:
1407:
1406:Philip Randle
1404:
1402:
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1386:Keith O'Nions
1384:
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1355:Anthony James
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1299:R. John Ellis
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1267:Martin Aitken
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1249:Royal Society
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491:transcription
488:
487:endonucleases
484:
481:
477:
473:
472:periodicities
469:
465:
461:
457:
456:DNA sequences
451:
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448:Royal Society
445:
441:
437:
433:
432:Alec Jeffreys
429:
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397:
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385:
377:
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365:
361:
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352:northern blot
348:
344:
340:
339:Southern blot
333:Southern blot
332:
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328:
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295:
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290:Southern blot
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111:Southern blot
109:
105:
98:
95:
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88:
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79:
73:(age 86)
59:
55:
48:
43:
38:
34:
22:
19:
1430:
1353:
1334:Ray Guillery
1291:
1204:the original
1194:
1182:. Retrieved
1178:
1169:
1161:the original
1153:"ABRF Award"
1147:
1135:. Retrieved
1131:the original
1121:
1113:the original
1103:
1091:. Retrieved
1087:
1078:
1066:. Retrieved
1062:the original
1048:
1036:. Retrieved
1032:the original
1022:
987:
983:
973:
964:
955:
944:
933:
908:
902:
869:
865:
861:
855:
813:
809:
801:
800:Maskos, U.;
795:
760:
751:Southern, E.
750:
745:
721:10.1038/4429
712:
708:
705:Southern, E.
704:
699:
666:
662:
658:
653:
620:
616:
613:Southern, E.
612:
593:the original
537:
531:
523:the original
466:chromosomal
453:
401:
381:
360:eastern blot
356:western blot
341:is used for
336:
329:technology.
323:
299:
270:Lasker Award
256:
255:
192:
163:Institutions
146:
136:Lasker Award
18:
1549:1938 births
1441:Nigel Unwin
1426:Ian Sneddon
1366:John Lawson
1344:Peter Higgs
1329:George Gray
1324:Ian Gibbons
1309:Alan Fersht
1137:19 December
1068:20 December
1038:19 December
949:Edina Trust
483:chromosomal
408:Royal Medal
236:/management
130:Royal Medal
71:7 June 1938
1543:Categories
1475:Statute 12
1411:Ivan Roitt
984:The Lancet
965:Nature.com
546:1842/11176
502:References
480:non-coding
464:eukaryotic
460:nucleotide
392:Affymetrix
327:microarray
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