241:. The cloverleaf model itself was one of the secondary structures for the first tRNA sequence that she developed with James Penswick, a student member of the Holley group. The study would later earn for Holley the Nobel Prize in Physiology or Medicine in 1968. Keller as well as the other members of the research team received part of the prize money.
236:
In 1965, she joined
Cornell University and worked with Holley, who was studying the transfer-RNA structure. She found that the workings of transfer RNA is best shown through the cloverleaf model and had demonstrated it using pipe cleaners and pieces of
181:. She was the youngest daughter of Frederick P. Beach and Ruth W. Beach, who were congregational missionaries stationed in the Chinese province. Her formal education began when the family relocated to the United States. She spent two years at
224:
included several studies that investigated the incorporation of labeled amino acids into proteins. Keller's research paved the way for more productive in vitro experiments on protein synthesis after she introduced the use of radioactive
244:
After her work at
Cornell, Keller's research focused more on cancer-causing genes. While she retired in 1988, she continued her research work until close to her death. Keller died on December 27, 1997, in
208:
After completing her postgraduate degree, Keller first worked at the
Cornell Medical College as an assistant professor. From 1948 to 1949, she was an Atomic Energy Commission fellow at
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149:. She is noted for her discoveries on protein formation. These included her development of the cloverleaf model of
447:"The Effect of Guanosine Diphosphate and Triphosphate on the Incorporation of Labeled Amino Acids into Proteins"
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The effect of guanosine diphosphate and triphosphate on the incorporation of labeled amino acids into proteins
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212:'s College of Medicine. After this period, she investigated the process of making proteins in cells at
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153:(ribonucleic acid), which shows how transfer RNA helps in directing the genetic information within the
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496:"Relation between phosphate energy donors and incorporation of labeled amino acids into proteins"
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Keller was married to
Geoffrey Keller in 1941 but the marriage later ended in divorce.
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386:"Three scientists share 2018 Nobel Prize in Physics for revolutionizing laser physics"
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727:"Intron splicing: a conserved internal signal in introns ofDrosophilapre-mRNAs"
620:"Dr. Elizabeth Keller, 79, Dies; Biochemist Helped RNA Study (Published 1997)"
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Keller was born
Elizabeth Waterbury Beach on December 28, 1918, in Diongloh,
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Intron
Splicing: A Conserved Internal Signal in Introns of Animal Pre-mRNAs
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Operators and
Promoters: The Story of Molecular Biology and Its Creators
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also led to the discovery of the initial stages of protein synthesis.
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42:
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Protein
Synthesis and Ribosome Structure: Translating the Genome
154:
655:. Berkeley, CA: University of California Press. p. 170.
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before obtaining her
Bachelor of Science degree at the
590:"Welcome to the University of Chicago Magazine Online"
445:
Keller, Elizabeth B.; Zamecnik, Paul C. (1956-07-01).
281:
Effects of therapeutic touch on tension headache pain
784:"The Biosynthesis of RNA's: Mechanisms and Controls"
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Protein formation, cloverleaf model of transfer RNA
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28:
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275:The Biosynthesis of RNA's: Mechanisms and Controls
725:Keller, Elizabeth B.; Noon, William A. (1985).
539:. Burlington, MA: Academic Press. p. 291.
161:'s set of works that earned him a share of the
680:. Berlin: John Wiley & Sons. p. 34.
537:Plant Cell Biology: From Astronomy to Zoology
229:in the process. Her and Zamecnik's work with
157:to form proteins. This model was included in
8:
361:"Keller, Elizabeth Beach | Encyclopedia.com"
676:Nierhaus, Knud H.; Wilson, Daniel (2009).
189:. Keller completed her master's degree at
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758:
511:
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855:20th-century American women scientists
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336:Encyclopedia of World Biography Online
702:"Francis J. Kelly, 78, one of the..."
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494:Zamecnik, P.C.; Keller, E.B. (1954).
218:Massachusetts Institute of Technology
128:Massachusetts Institute of Technology
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220:(1949-1960). Her collaboration with
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835:20th-century American biochemists
193:and her Ph.D. in biochemistry at
249:due to complications from acute
500:Journal of Biological Chemistry
451:Journal of Biological Chemistry
1:
860:American expatriates in China
618:Burkhart, Ford (1997-12-28).
513:10.1016/S0021-9258(18)65561-9
464:10.1016/S0021-9258(18)65227-5
840:University of Chicago alumni
651:Echols, Harrison G. (2001).
191:George Washington University
876:
850:American women scientists
845:Cornell University alumni
133:
94:
535:Wayne, Randy O. (2009).
332:"Elizabeth Beach Keller"
195:Cornell Medical College
799:Cite journal requires
743:10.1093/nar/13.13.4971
731:Nucleic Acids Research
299:List of RNA biologists
294:History of RNA biology
140:Elizabeth Beach Keller
23:Elizabeth Beach Keller
594:magazine.uchicago.edu
421:"Elizabeth B. Keller"
210:Ohio State University
187:University of Chicago
365:www.encyclopedia.com
782:Keller, Elizabeth.
707:. December 30, 1997
247:Rochester, New York
142:(1918—1997) was an
62:Rochester, New York
16:American biochemist
624:The New York Times
425:Cornell University
398:10.34193/ei-a-9774
214:Harvard University
124:Harvard University
120:Cornell University
81:Cornell University
737:(13): 4971–4981.
687:978-3-527-61638-1
662:978-0-520-92076-7
561:"Mahlon Hoagland"
546:978-0-12-374233-9
384:Kulkarni, Sneha.
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110:Molecular biology
96:Scientific career
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342:November 19,
340:. Retrieved
338:. GALE. 2005
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151:transfer RNA
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116:Institutions
106:Biochemistry
95:
56:(1997-12-27)
830:1997 deaths
825:1918 births
571:October 24,
430:October 24,
163:Nobel Prize
69:Nationality
819:Categories
711:2020-11-04
637:2020-11-12
599:2020-11-04
403:2020-10-12
370:2020-10-12
305:References
147:biochemist
35:1918-12-28
751:0305-1048
632:0362-4331
473:0021-9258
169:Biography
522:13192089
481:13345797
288:See also
251:leukemia
216:and the
144:American
72:American
769:2410858
227:leucine
45:, China
767:
760:321838
757:
749:
684:
659:
630:
567:. 2016
543:
520:
479:
471:
283:(1986)
277:(1985)
271:(1984)
265:(1956)
239:Velcro
204:Career
102:Fields
43:Fujian
257:Works
179:China
805:help
765:PMID
747:ISSN
682:ISBN
657:ISBN
628:ISSN
573:2020
541:ISBN
518:PMID
477:PMID
469:ISSN
432:2020
344:2020
51:Died
29:Born
755:PMC
739:doi
565:CSH
508:doi
504:209
459:doi
455:221
394:doi
155:DNA
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Text is available under the Creative Commons Attribution-ShareAlike License. Additional terms may apply.