264:, waiting for a defined period of time, extracting the liver, and examining sub-cellular fractions for radioactivity. He found that after longer periods of times (hours, days) radioactively labeled proteins were present in all subcellular fractions. However, if they allowed less time to pass, radioactivity was found in only certain particles, which they deemed the sites of proteins synthesis. These particles were named ribosomes.
279:. Hoagland's major contribution to the laboratory was in his work with amino acid activating enzymes. He discovered that certain enzymes were required to activate amino acids so they could associate with tRNA molecules and eventually be incorporated into new protein molecules. These enzymes were named
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By the time
Hoagland had joined Huntington Laboratories, his colleagues there were well known for their work in protein synthesis. In the early 1950s, Hoagland and his associates were able to show that
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From 1953 to 1967, Hoagland served as an associate professor of microbiology at
Harvard Medical School. In 1967, upon leaving Harvard he was appointed professor in the biochemistry department at the
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with intentions of becoming a pediatric surgeon. After a bout with tuberculosis, Hoagland was forced to change career directions and became involved with research.
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After graduating from
Harvard Medical School he, his daughter Judith and his wife Elizabeth Stratton Hoagland lived in the home of designer
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and Anna
Hoagland. Hudson was an American physiologist who was known for co-founding the Worcester Foundation for Experimental Biology with
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The Way Life Works: The
Science Lover's Illustrated Guide to How Life Grows, Develops, Reproduces, and Gets Along
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During their experiments with rat liver cells, Hoagland and
Zamecnik noticed that in the presence of
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Hoagland, MB et al. "A soluble ribonucleic acid intermediate in protein synthesis.”
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Mahlon
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532:(4th ed.). New York: W.H. Freeman and Company. pp. 1034–1035.
283:. Incidentally, this lab's discovery of tRNA supported the theory of
271:, amino acids associate with heat soluble RNA, which was later named
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Mahlon
Hoagland's other work involved the carcinogenic effects of
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The Eighth Day of
Creation: Makers of the Revolution in Biology
153:(October 5, 1921 – September 18, 2009) was an American
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when he discovered the initial steps of protein synthesis.
275:(tRNA). This amino acid and tRNA complex was later called
260:. They did this by giving a rat injections of radioactive
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Members of the United States National Academy of Sciences
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for several years while he commuted to Boston for work.
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in forming proteins. He was working with Zamecnick and
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390:"Mahlon Hoagland at the Cape Ann Museum"
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209:and her family. Kenyon was part of the
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220:Hoagland took a research position at
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530:Lehninger Principles of Biochemistry
497:Dodson, Bert, and Mahlon Hoagland.
285:complementarity (molecular biology)
528:Cox, Michael M.; David L. Nelson.
14:
877:Geisel School of Medicine faculty
213:and Hoagland worked with them in
190:. Mahlon Hoagland graduated from
174:Mahlon Bush Hoagland was born in
485:Journal of Biological Chemistry
16:American biochemist (1921–2009)
501:. New York: Times Books, 1995.
222:Massachusetts General Hospital
1:
872:Harvard Medical School alumni
892:Recipients of Franklin Medal
470:(Simon & Schuster, 1979)
85:Elizabeth Stratton Hoagland
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551:- Daily Telegraph obituary
487:. 1958 Mar; 231(1):241-57.
317:regeneration and control.
281:aminoacyl tRNA synthetases
549:Professor Mahlon Hoagland
494:. New York: Norton, 1990.
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466:Horace Freeland Judson,
241:Dartmouth Medical School
134:Dartmouth Medical School
867:Williams College alumni
440:"Hoagland, Mahlon Bush"
887:The Hill School alumni
200:Harvard Medical School
129:Harvard Medical School
69:Harvard Medical School
686:Barbara Hoffman Souza
254:polypeptide synthesis
194:in 1940 and attended
36:Boston, Massachusetts
852:American biochemists
826:Hetty Beatty Whitney
591:Folly Cove Designers
514:Mahlon Bush Hoagland
369:Mahlon Bush Hoagland
211:Folly Cove Designers
151:Mahlon Bush Hoagland
23:Mahlon Bush Hoagland
791:(Muriel) Lee Steele
706:Elizabeth Iarrobino
605:Virginia Lee Burton
298:He was awarded the
731:Euthymia Maletskos
691:Elizabeth Holloran
309:, biosynthesis of
47:September 18, 2009
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756:Lee Kingman Natti
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414:"Mahlon Hoagland"
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111:Scientific career
59:Thetford, Vermont
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518:. Retrieved
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444:the original
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397:. Retrieved
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348:(obituary),
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287:proposed by
273:transfer RNA
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230:transfer RNA
219:
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159:transfer RNA
150:
149:
125:Institutions
110:
862:2009 deaths
857:1921 births
831:Lili Wilson
816:Ellen Tufts
656:Mabel Greer
641:Ida Corliss
636:Aino Clarke
424:October 24,
262:amino acids
846:Categories
751:Eino Natti
676:Ruth Hendy
661:Mary Greer
520:2007-05-11
506:References
450:2007-05-11
399:2021-01-14
375:2007-05-11
311:coenzyme A
256:occurs on
170:Early life
155:biochemist
120:Biochemist
51:2009-09-19
621:Ida Bruno
307:beryllium
302:in 1976.
258:ribosomes
215:Annisquam
165:Biography
614:Artists
49: (
598:Leader
420:. 2016
289:Watson
176:Boston
117:Fields
100:Awards
90:Parent
82:Spouse
478:Works
321:Notes
315:liver
293:Crick
38:, USA
426:2020
291:and
247:Work
44:Died
29:Born
418:CSH
269:ATP
848::
459:^
416:.
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378:.
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53:)
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