3055:
332:
The activity of eEF-2K is dependent on calcium and calmodulin. Activation of eEF-2K proceeds by a sequential two-step mechanism. First, calcium-calmodulin binds with high affinity to activate the kinase domain, triggering rapid autophosphorylation of Thr-348. In the second step, autophosphorylation
323:
The only known physiological substrate of eEF-2K is eEF-2. Phosphorylation of eEF-2 at Thr-56 by eEF-2K leads to inhibition of the elongation phase of protein synthesis. Phosphorylation of Thr-56 is thought to reduce the affinity of eEF-2 for the ribosome, thereby slowing down the overall rate of
333:
of Thr-348 leads to a conformational change in the kinase likely supported by the binding of phospho-Thr-348 to an allosteric phosphate binding pocket in the kinase domain. This increases the activity of eEF-2K against its substrate, elongation factor 2.
918:
1203:
314:
of this enzyme class is "ATP: phosphotransferase". Other names in common use include Ca/CaM-kinase III, calmodulin-dependent protein kinase III, CaM kinase III, eEF2 kinase, eEF-2K, eEF2K, EF2K, and STK19.
344:
eEF-2K expression is often upregulated in cancer cells, including breast and pancreatic cancers and promotes cell proliferation, survival, motility/migration, invasion and tumorigenesis.
324:
elongation. However, there is growing evidence to suggest that translation of certain mRNAs is actually increased by phosphorylation of eEF-2 by eEF-2K, especially in a neuronal context.
911:
628:
Ashour AA, Abdel-Aziz AA, Mansour AM, Alpay SN, Huo L, Ozpolat B (Jan 22, 2014). "Targeting elongation factor-2 kinase (eEF-2K) induces apoptosis in human pancreatic cancer cells".
252:
466:
Tavares CD, O'Brien JP, Abramczyk O, Devkota AK, Shores KS, Ferguson SB, Kaoud TS, Warthaka M, Marshall KD, Keller KM, Zhang Y, Brodbelt JS, Ozpolat B, Dalby KN (Mar 20, 2012).
904:
336:
eEF-2K can gain calcium-independent activity through autophosphorylation of Ser-500. However, calmodulin must remain bound to the enzyme for its activity to be sustained.
1111:
167:
828:"Stimulation of the AMP-activated protein kinase leads to activation of eukaryotic elongation factor 2 kinase and to its phosphorylation at a novel site, serine 398"
186:
1659:
2498:
962:
468:"Calcium/calmodulin stimulates the autophosphorylation of elongation factor 2 kinase on Thr-348 and Ser-500 to regulate its activity and calcium dependence"
2607:
1345:
1232:
1620:
3112:
2593:
2058:
949:
931:
2695:
2576:
571:"Targeted silencing of elongation factor 2 kinase suppresses growth and sensitizes tumors to doxorubicin in an orthotopic model of breast cancer"
2282:
1151:
3136:
2346:
1321:
361:
Ryazanov AG, Shestakova EA, Natapov PG (Jul 14, 1988). "Phosphorylation of elongation factor 2 by EF-2 kinase affects rate of translation".
2602:
1136:
2659:
2334:
569:
Tekedereli I, Alpay SN, Tavares CD, Cobanoglu ZE, Kaoud TS, Sahin I, Sood AK, Lopez-Berestein G, Dalby KN, Ozpolat B (Mar 20, 2012).
2774:
1591:
1581:
1266:
179:
2273:
797:
Sans MD, Xie Q, Williams JA (2004). "Regulation of translation elongation and phosphorylation of eEF2 in rat pancreatic acini".
2542:
2214:
1576:
1567:
307:
130:
518:
Tavares CD, Ferguson SB, Giles DH, Wang Q, Wellmann RM, O'Brien JP, Warthaka M, Brodbelt JS, Ren P, Dalby KN (Aug 22, 2014).
106:
2930:
3105:
1957:
1454:
1445:
1102:
1048:
3045:
678:"Purification and characterization of calmodulin-dependent protein kinase III from rabbit reticulocytes and rat pancreas"
1145:
896:
2169:
1483:
2915:
3031:
3018:
3005:
2992:
2979:
2966:
2953:
2159:
2154:
2149:
2139:
2134:
2129:
2119:
1914:
1689:
1285:
756:"A novel method to identify protein kinase substrates: eEF2 kinase is phosphorylated and inhibited by SAPK4/p38δ"
124:
2925:
3098:
2879:
2822:
2382:
2373:
2324:
1090:
935:
259:
212:
29:
414:"Elongation factor-2 phosphorylation in dendrites and the regulation of dendritic mRNA translation in neurons"
111:
2827:
2682:
2105:
263:
191:
237:
99:
3141:
2848:
2767:
1381:
275:
2920:
1948:
582:
370:
127:
2884:
271:
267:
51:
2456:
3131:
2817:
2559:
2513:
653:
394:
713:"Phosphorylation of elongation factor 2 during Ca(2+)-mediated secretion from rat parotid acini"
1819:
1528:
884:
849:
814:
785:
742:
699:
645:
610:
551:
497:
445:
386:
227:
118:
3082:
2863:
2858:
2832:
2760:
2412:
1654:
1644:
1639:
1557:
1548:
1478:
1469:
1415:
1406:
1063:
874:
839:
806:
775:
767:
732:
724:
689:
637:
600:
590:
541:
531:
487:
479:
435:
425:
378:
87:
2910:
2894:
2807:
2238:
1309:
1304:
1299:
311:
63:
34:
586:
374:
3059:
2948:
2889:
737:
712:
605:
570:
546:
519:
492:
467:
440:
413:
162:
879:
862:
780:
755:
694:
677:
142:
3125:
2853:
2812:
1362:
1294:
137:
657:
2802:
2233:
1058:
398:
595:
3026:
2961:
2797:
2439:
2071:
2011:
1894:
1814:
1538:
287:
146:
3054:
810:
771:
2527:
1001:
641:
204:
520:"The molecular mechanism of eukaryotic elongation factor 2 kinase activation"
430:
3000:
2974:
1488:
536:
299:
223:
888:
853:
844:
827:
818:
789:
649:
614:
555:
501:
449:
746:
703:
390:
1844:
1739:
1734:
1729:
215:
75:
2503:
2481:
2476:
2466:
2461:
2263:
2258:
2253:
2248:
2243:
2228:
2223:
1874:
1839:
1078:
1073:
1068:
303:
94:
728:
483:
3078:
3075:
3013:
2783:
2733:
2728:
2723:
2718:
2713:
2708:
2703:
2654:
2649:
2644:
2639:
2634:
2617:
2612:
2486:
2471:
2422:
2417:
2402:
2397:
2392:
2387:
2361:
2356:
2351:
2339:
2317:
2312:
2204:
2179:
1854:
1679:
1674:
1669:
1664:
1649:
1493:
1430:
1425:
1420:
1396:
1222:
1217:
1191:
1186:
1181:
1171:
1166:
1156:
996:
927:
412:
Heise C, Gardoni F, Culotta L, di Luca M, Verpelli C, Sala C (2014).
382:
295:
291:
290:, specifically those transferring a phosphate group to the sidechain
219:
174:
70:
58:
46:
2987:
2629:
2622:
2532:
2429:
2329:
2307:
2302:
2297:
2292:
2287:
2199:
2194:
2189:
2184:
2174:
2144:
2124:
2001:
1996:
1977:
1972:
1962:
1938:
1933:
1928:
1904:
1899:
1889:
1884:
1879:
1869:
1849:
1834:
1829:
1824:
1804:
1799:
1789:
1784:
1779:
1774:
1769:
1759:
1754:
1749:
1744:
1724:
1719:
1714:
1709:
1704:
1699:
1684:
1634:
1629:
1523:
1518:
1513:
1508:
1503:
1498:
1459:
1391:
1386:
1335:
1330:
1256:
1251:
1246:
1212:
1204:
3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring) kinase
1006:
991:
986:
981:
976:
971:
2522:
2449:
2444:
2434:
2407:
2164:
2114:
2095:
2090:
2085:
2080:
2035:
2030:
2025:
2020:
1967:
1923:
1864:
1859:
1809:
1794:
1764:
1694:
1610:
1605:
1600:
1533:
1435:
1376:
1371:
1275:
1241:
1126:
1121:
1116:
1085:
1053:
1041:
1036:
1031:
1021:
1016:
82:
2756:
2680:
2056:
947:
900:
863:"Elongation factor-2 kinase and its newly discovered relatives"
2491:
1026:
1011:
2752:
241:
3086:
3043:
240:
2939:
2903:
2872:
2841:
2790:
2694:
2592:
2575:
2558:
2541:
2512:
2372:
2272:
2213:
2104:
2070:
2010:
1986:
1947:
1913:
1619:
1590:
1566:
1547:
1468:
1444:
1405:
1361:
1344:
1320:
1284:
1265:
1231:
1202:
1135:
1101:
961:
185:
173:
161:
156:
136:
117:
105:
93:
81:
69:
57:
45:
40:
28:
23:
18:
246:
676:Mitsui K, Brady M, Palfrey HC, Nairn AC (1993).
513:
511:
461:
459:
3106:
2768:
963:Non-specific serine/threonine protein kinases
912:
8:
3113:
3099:
2775:
2761:
2753:
2691:
2677:
2067:
2053:
1346:Goodpasture-antigen-binding protein kinase
958:
944:
919:
905:
897:
153:
2059:Serine/threonine-specific protein kinases
1233:(isocitrate dehydrogenase (NADP+)) kinase
950:Serine/threonine-specific protein kinases
932:Serine/threonine-specific protein kinases
878:
843:
779:
736:
693:
604:
594:
545:
535:
491:
439:
429:
278:(ADP) and elongation factor 2 phosphate.
239:
2594:Receptor protein serine/threonine kinase
3050:
2577:Low-density-lipoprotein receptor kinase
353:
15:
1322:Fas-activated serine/threonine kinase
826:Browne GJ, Finn SG, Proud CG (2004).
754:Knebel A, Morrice N, Cohen P (2001).
286:This enzyme belongs to the family of
19:eukaryotic elongation factor-2 kinase
7:
3071:
3069:
2603:Bone morphogenetic protein receptors
1137:Dephospho-(reductase kinase) kinase
524:The Journal of Biological Chemistry
247:{\displaystyle \rightleftharpoons }
3085:. You can help Knowledge (XXG) by
1592:G-protein coupled receptor kinases
711:Hincke MT, Nairn AC (March 1992).
418:Frontiers in Cellular Neuroscience
14:
1582:Beta adrenergic receptor kinase-2
1267:(tyrosine 3-monooxygenase) kinase
3053:
2274:Mitogen-activated protein kinase
308:protein-serine/threonine kinases
2660:Anti-MĂĽllerian hormone receptor
2543:(acetyl-CoA carboxylase) kinase
2215:(RNA-polymerase)-subunit kinase
1577:Beta adrenergic receptor kinase
1568:Beta adrenergic receptor kinase
2283:Extracellular signal-regulated
1:
2347:P38 mitogen-activated protein
1446:cGMP-dependent protein kinase
1407:cAMP-dependent protein kinase
1103:Pyruvate dehydrogenase kinase
1049:Ataxia telangiectasia mutated
880:10.1016/S0014-5793(02)02299-8
799:Biochem. Biophys. Res. Commun
695:10.1016/S0021-9258(19)38667-3
3137:Enzymes of unknown structure
1146:AMP-activated protein kinase
596:10.1371/journal.pone.0041171
2061:(EC 2.7.11.21-EC 2.7.11.30)
3158:
3068:
1988:Elongation factor 2 kinase
952:(EC 2.7.11.1-EC 2.7.11.20)
811:10.1016/j.bbrc.2004.04.164
209:elongation factor 2 kinase
2931:Michaelis–Menten kinetics
2690:
2676:
2383:MAP kinase kinase kinases
2066:
2052:
1915:Myosin light-chain kinase
1621:Ca2+/calmodulin-dependent
1286:Myosin-heavy-chain kinase
957:
943:
642:10.1007/s10495-013-0927-2
152:
2823:Diffusion-limited enzyme
2683:Dual-specificity kinases
772:10.1093/emboj/20.16.4360
431:10.3389/fncel.2014.00035
2106:Cyclin-dependent kinase
537:10.1074/jbc.m114.577148
3081:-related article is a
845:10.1074/jbc.M309773200
248:
2916:Eadie–Hofstee diagram
2849:Allosteric regulation
276:adenosine diphosphate
249:
2926:Lineweaver–Burk plot
1949:Phosphorylase kinase
861:Ryazanov AG (2002).
238:
587:2012PLoSO...741171T
375:1988Natur.334..170R
268:elongation factor 2
262:of this enzyme are
2885:Enzyme superfamily
2818:Enzyme promiscuity
2560:Tropomyosin kinase
2514:Tau-protein kinase
270:, whereas its two
244:
3094:
3093:
3041:
3040:
2750:
2749:
2746:
2745:
2742:
2741:
2672:
2671:
2668:
2667:
2048:
2047:
2044:
2043:
1529:Protein kinase N1
1484:Protein kinase Cζ
729:10.1042/bj2820877
484:10.1021/bi201788e
254:ADP + phosphate.
228:chemical reaction
201:
200:
197:
196:
100:metabolic pathway
3149:
3115:
3108:
3101:
3070:
3058:
3057:
3049:
2921:Hanes–Woolf plot
2864:Enzyme activator
2859:Enzyme inhibitor
2833:Enzyme catalysis
2777:
2770:
2763:
2754:
2692:
2678:
2325:C-Jun N-terminal
2068:
2054:
1558:Rhodopsin kinase
1549:Rhodopsin kinase
1479:Protein kinase C
1470:Protein kinase C
1455:Protein kinase G
1416:Protein kinase A
1027:Protein kinase B
959:
945:
921:
914:
907:
898:
892:
882:
857:
847:
838:(13): 12220–31.
822:
793:
783:
750:
740:
723:(Pt 3): 877–82.
707:
697:
688:(18): 13422–33.
662:
661:
625:
619:
618:
608:
598:
566:
560:
559:
549:
539:
530:(34): 23901–16.
515:
506:
505:
495:
463:
454:
453:
443:
433:
409:
403:
402:
383:10.1038/334170a0
358:
253:
251:
250:
245:
154:
16:
3157:
3156:
3152:
3151:
3150:
3148:
3147:
3146:
3122:
3121:
3120:
3119:
3066:
3064:
3052:
3044:
3042:
3037:
2949:Oxidoreductases
2935:
2911:Enzyme kinetics
2899:
2895:List of enzymes
2868:
2837:
2808:Catalytic triad
2786:
2781:
2751:
2738:
2686:
2664:
2588:
2571:
2554:
2537:
2508:
2368:
2268:
2239:P70-S6 Kinase 1
2209:
2100:
2062:
2040:
2006:
1982:
1943:
1909:
1615:
1586:
1562:
1543:
1464:
1440:
1401:
1357:
1340:
1316:
1310:Aurora C kinase
1305:Aurora B kinase
1300:Aurora A kinase
1280:
1261:
1227:
1198:
1131:
1097:
953:
939:
925:
895:
860:
825:
796:
753:
710:
675:
671:
669:Further reading
666:
665:
627:
626:
622:
568:
567:
563:
517:
516:
509:
478:(11): 2232–45.
465:
464:
457:
411:
410:
406:
369:(6178): 170–3.
360:
359:
355:
350:
342:
330:
321:
312:systematic name
284:
236:
235:
12:
11:
5:
3155:
3153:
3145:
3144:
3139:
3134:
3124:
3123:
3118:
3117:
3110:
3103:
3095:
3092:
3091:
3063:
3062:
3039:
3038:
3036:
3035:
3022:
3009:
2996:
2983:
2970:
2957:
2943:
2941:
2937:
2936:
2934:
2933:
2928:
2923:
2918:
2913:
2907:
2905:
2901:
2900:
2898:
2897:
2892:
2887:
2882:
2876:
2874:
2873:Classification
2870:
2869:
2867:
2866:
2861:
2856:
2851:
2845:
2843:
2839:
2838:
2836:
2835:
2830:
2825:
2820:
2815:
2810:
2805:
2800:
2794:
2792:
2788:
2787:
2782:
2780:
2779:
2772:
2765:
2757:
2748:
2747:
2744:
2743:
2740:
2739:
2737:
2736:
2731:
2726:
2721:
2716:
2711:
2706:
2700:
2698:
2688:
2687:
2681:
2674:
2673:
2670:
2669:
2666:
2665:
2663:
2662:
2657:
2652:
2647:
2642:
2637:
2632:
2627:
2626:
2625:
2620:
2615:
2610:
2599:
2597:
2596:(EC 2.7.11.30)
2590:
2589:
2587:
2586:
2582:
2580:
2579:(EC 2.7.11.29)
2573:
2572:
2570:
2569:
2565:
2563:
2562:(EC 2.7.11.28)
2556:
2555:
2553:
2552:
2548:
2546:
2545:(EC 2.7.11.27)
2539:
2538:
2536:
2535:
2530:
2525:
2519:
2517:
2516:(EC 2.7.11.26)
2510:
2509:
2507:
2506:
2501:
2496:
2495:
2494:
2489:
2484:
2479:
2474:
2469:
2464:
2454:
2453:
2452:
2447:
2442:
2437:
2427:
2426:
2425:
2420:
2415:
2410:
2405:
2400:
2395:
2390:
2379:
2377:
2376:(EC 2.7.11.25)
2370:
2369:
2367:
2366:
2365:
2364:
2359:
2354:
2344:
2343:
2342:
2337:
2332:
2322:
2321:
2320:
2315:
2310:
2305:
2300:
2295:
2290:
2279:
2277:
2276:(EC 2.7.11.24)
2270:
2269:
2267:
2266:
2261:
2256:
2251:
2246:
2241:
2236:
2231:
2226:
2220:
2218:
2217:(EC 2.7.11.23)
2211:
2210:
2208:
2207:
2202:
2197:
2192:
2187:
2182:
2177:
2172:
2167:
2162:
2157:
2152:
2147:
2142:
2137:
2132:
2127:
2122:
2117:
2111:
2109:
2108:(EC 2.7.11.22)
2102:
2101:
2099:
2098:
2093:
2088:
2083:
2077:
2075:
2074:(EC 2.7.11.21)
2064:
2063:
2057:
2050:
2049:
2046:
2045:
2042:
2041:
2039:
2038:
2033:
2028:
2023:
2017:
2015:
2014:(EC 2.7.11.21)
2008:
2007:
2005:
2004:
1999:
1993:
1991:
1990:(EC 2.7.11.20)
1984:
1983:
1981:
1980:
1975:
1970:
1965:
1960:
1954:
1952:
1951:(EC 2.7.11.19)
1945:
1944:
1942:
1941:
1936:
1931:
1926:
1920:
1918:
1917:(EC 2.7.11.18)
1911:
1910:
1908:
1907:
1902:
1897:
1892:
1887:
1882:
1877:
1872:
1867:
1862:
1857:
1852:
1847:
1842:
1837:
1832:
1827:
1822:
1817:
1812:
1807:
1802:
1797:
1792:
1787:
1782:
1777:
1772:
1767:
1762:
1757:
1752:
1747:
1742:
1737:
1732:
1727:
1722:
1717:
1712:
1707:
1702:
1697:
1692:
1687:
1682:
1677:
1672:
1667:
1662:
1657:
1652:
1647:
1642:
1637:
1632:
1626:
1624:
1623:(EC 2.7.11.17)
1617:
1616:
1614:
1613:
1608:
1603:
1597:
1595:
1594:(EC 2.7.11.16)
1588:
1587:
1585:
1584:
1579:
1573:
1571:
1570:(EC 2.7.11.15)
1564:
1563:
1561:
1560:
1554:
1552:
1551:(EC 2.7.11.14)
1545:
1544:
1542:
1541:
1536:
1531:
1526:
1521:
1516:
1511:
1506:
1501:
1496:
1491:
1486:
1481:
1475:
1473:
1472:(EC 2.7.11.13)
1466:
1465:
1463:
1462:
1457:
1451:
1449:
1448:(EC 2.7.11.12)
1442:
1441:
1439:
1438:
1433:
1428:
1423:
1418:
1412:
1410:
1409:(EC 2.7.11.11)
1403:
1402:
1400:
1399:
1394:
1389:
1384:
1379:
1374:
1368:
1366:
1365:(EC 2.7.11.10)
1359:
1358:
1356:
1355:
1351:
1349:
1342:
1341:
1339:
1338:
1333:
1327:
1325:
1318:
1317:
1315:
1314:
1313:
1312:
1307:
1302:
1291:
1289:
1282:
1281:
1279:
1278:
1272:
1270:
1263:
1262:
1260:
1259:
1254:
1249:
1244:
1238:
1236:
1229:
1228:
1226:
1225:
1220:
1215:
1209:
1207:
1200:
1199:
1197:
1196:
1195:
1194:
1189:
1184:
1176:
1175:
1174:
1169:
1161:
1160:
1159:
1154:
1142:
1140:
1133:
1132:
1130:
1129:
1124:
1119:
1114:
1108:
1106:
1099:
1098:
1096:
1095:
1094:
1093:
1083:
1082:
1081:
1076:
1071:
1066:
1056:
1051:
1046:
1045:
1044:
1039:
1034:
1024:
1019:
1014:
1009:
1004:
999:
994:
989:
984:
979:
974:
968:
966:
955:
954:
948:
941:
940:
926:
924:
923:
916:
909:
901:
894:
893:
858:
823:
794:
766:(16): 4360–9.
751:
708:
672:
670:
667:
664:
663:
620:
561:
507:
455:
404:
352:
351:
349:
346:
341:
338:
329:
326:
320:
317:
283:
280:
258:Thus, the two
256:
255:
243:
199:
198:
195:
194:
189:
183:
182:
177:
171:
170:
165:
159:
158:
150:
149:
140:
134:
133:
122:
115:
114:
109:
103:
102:
97:
91:
90:
85:
79:
78:
73:
67:
66:
61:
55:
54:
49:
43:
42:
38:
37:
32:
26:
25:
21:
20:
13:
10:
9:
6:
4:
3:
2:
3154:
3143:
3140:
3138:
3135:
3133:
3130:
3129:
3127:
3116:
3111:
3109:
3104:
3102:
3097:
3096:
3090:
3088:
3084:
3080:
3077:
3072:
3067:
3061:
3056:
3051:
3047:
3033:
3029:
3028:
3023:
3020:
3016:
3015:
3010:
3007:
3003:
3002:
2997:
2994:
2990:
2989:
2984:
2981:
2977:
2976:
2971:
2968:
2964:
2963:
2958:
2955:
2951:
2950:
2945:
2944:
2942:
2938:
2932:
2929:
2927:
2924:
2922:
2919:
2917:
2914:
2912:
2909:
2908:
2906:
2902:
2896:
2893:
2891:
2890:Enzyme family
2888:
2886:
2883:
2881:
2878:
2877:
2875:
2871:
2865:
2862:
2860:
2857:
2855:
2854:Cooperativity
2852:
2850:
2847:
2846:
2844:
2840:
2834:
2831:
2829:
2826:
2824:
2821:
2819:
2816:
2814:
2813:Oxyanion hole
2811:
2809:
2806:
2804:
2801:
2799:
2796:
2795:
2793:
2789:
2785:
2778:
2773:
2771:
2766:
2764:
2759:
2758:
2755:
2735:
2732:
2730:
2727:
2725:
2722:
2720:
2717:
2715:
2712:
2710:
2707:
2705:
2702:
2701:
2699:
2697:
2693:
2689:
2684:
2679:
2675:
2661:
2658:
2656:
2653:
2651:
2648:
2646:
2643:
2641:
2638:
2636:
2633:
2631:
2628:
2624:
2621:
2619:
2616:
2614:
2611:
2609:
2606:
2605:
2604:
2601:
2600:
2598:
2595:
2591:
2584:
2583:
2581:
2578:
2574:
2567:
2566:
2564:
2561:
2557:
2550:
2549:
2547:
2544:
2540:
2534:
2531:
2529:
2526:
2524:
2521:
2520:
2518:
2515:
2511:
2505:
2502:
2500:
2497:
2493:
2490:
2488:
2485:
2483:
2480:
2478:
2475:
2473:
2470:
2468:
2465:
2463:
2460:
2459:
2458:
2455:
2451:
2448:
2446:
2443:
2441:
2438:
2436:
2433:
2432:
2431:
2428:
2424:
2421:
2419:
2416:
2414:
2411:
2409:
2406:
2404:
2401:
2399:
2396:
2394:
2391:
2389:
2386:
2385:
2384:
2381:
2380:
2378:
2375:
2371:
2363:
2360:
2358:
2355:
2353:
2350:
2349:
2348:
2345:
2341:
2338:
2336:
2333:
2331:
2328:
2327:
2326:
2323:
2319:
2316:
2314:
2311:
2309:
2306:
2304:
2301:
2299:
2296:
2294:
2291:
2289:
2286:
2285:
2284:
2281:
2280:
2278:
2275:
2271:
2265:
2262:
2260:
2257:
2255:
2252:
2250:
2247:
2245:
2242:
2240:
2237:
2235:
2232:
2230:
2227:
2225:
2222:
2221:
2219:
2216:
2212:
2206:
2203:
2201:
2198:
2196:
2193:
2191:
2188:
2186:
2183:
2181:
2178:
2176:
2173:
2171:
2168:
2166:
2163:
2161:
2158:
2156:
2153:
2151:
2148:
2146:
2143:
2141:
2138:
2136:
2133:
2131:
2128:
2126:
2123:
2121:
2118:
2116:
2113:
2112:
2110:
2107:
2103:
2097:
2094:
2092:
2089:
2087:
2084:
2082:
2079:
2078:
2076:
2073:
2069:
2065:
2060:
2055:
2051:
2037:
2034:
2032:
2029:
2027:
2024:
2022:
2019:
2018:
2016:
2013:
2009:
2003:
2000:
1998:
1995:
1994:
1992:
1989:
1985:
1979:
1976:
1974:
1971:
1969:
1966:
1964:
1961:
1959:
1956:
1955:
1953:
1950:
1946:
1940:
1937:
1935:
1932:
1930:
1927:
1925:
1922:
1921:
1919:
1916:
1912:
1906:
1903:
1901:
1898:
1896:
1893:
1891:
1888:
1886:
1883:
1881:
1878:
1876:
1873:
1871:
1868:
1866:
1863:
1861:
1858:
1856:
1853:
1851:
1848:
1846:
1843:
1841:
1838:
1836:
1833:
1831:
1828:
1826:
1823:
1821:
1818:
1816:
1813:
1811:
1808:
1806:
1803:
1801:
1798:
1796:
1793:
1791:
1788:
1786:
1783:
1781:
1778:
1776:
1773:
1771:
1768:
1766:
1763:
1761:
1758:
1756:
1753:
1751:
1748:
1746:
1743:
1741:
1738:
1736:
1733:
1731:
1728:
1726:
1723:
1721:
1718:
1716:
1713:
1711:
1708:
1706:
1703:
1701:
1698:
1696:
1693:
1691:
1688:
1686:
1683:
1681:
1678:
1676:
1673:
1671:
1668:
1666:
1663:
1661:
1658:
1656:
1653:
1651:
1648:
1646:
1643:
1641:
1638:
1636:
1633:
1631:
1628:
1627:
1625:
1622:
1618:
1612:
1609:
1607:
1604:
1602:
1599:
1598:
1596:
1593:
1589:
1583:
1580:
1578:
1575:
1574:
1572:
1569:
1565:
1559:
1556:
1555:
1553:
1550:
1546:
1540:
1537:
1535:
1532:
1530:
1527:
1525:
1522:
1520:
1517:
1515:
1512:
1510:
1507:
1505:
1502:
1500:
1497:
1495:
1492:
1490:
1487:
1485:
1482:
1480:
1477:
1476:
1474:
1471:
1467:
1461:
1458:
1456:
1453:
1452:
1450:
1447:
1443:
1437:
1434:
1432:
1429:
1427:
1424:
1422:
1419:
1417:
1414:
1413:
1411:
1408:
1404:
1398:
1395:
1393:
1390:
1388:
1385:
1383:
1380:
1378:
1375:
1373:
1370:
1369:
1367:
1364:
1360:
1353:
1352:
1350:
1348:(EC 2.7.11.9)
1347:
1343:
1337:
1334:
1332:
1329:
1328:
1326:
1324:(EC 2.7.11.8)
1323:
1319:
1311:
1308:
1306:
1303:
1301:
1298:
1297:
1296:
1295:Aurora kinase
1293:
1292:
1290:
1288:(EC 2.7.11.7)
1287:
1283:
1277:
1274:
1273:
1271:
1269:(EC 2.7.11.6)
1268:
1264:
1258:
1255:
1253:
1250:
1248:
1245:
1243:
1240:
1239:
1237:
1235:(EC 2.7.11.5)
1234:
1230:
1224:
1221:
1219:
1216:
1214:
1211:
1210:
1208:
1206:(EC 2.7.11.4)
1205:
1201:
1193:
1190:
1188:
1185:
1183:
1180:
1179:
1177:
1173:
1170:
1168:
1165:
1164:
1162:
1158:
1155:
1153:
1150:
1149:
1147:
1144:
1143:
1141:
1139:(EC 2.7.11.3)
1138:
1134:
1128:
1125:
1123:
1120:
1118:
1115:
1113:
1110:
1109:
1107:
1105:(EC 2.7.11.2)
1104:
1100:
1092:
1089:
1088:
1087:
1084:
1080:
1077:
1075:
1072:
1070:
1067:
1065:
1062:
1061:
1060:
1059:EIF-2 kinases
1057:
1055:
1052:
1050:
1047:
1043:
1040:
1038:
1035:
1033:
1030:
1029:
1028:
1025:
1023:
1020:
1018:
1015:
1013:
1010:
1008:
1005:
1003:
1000:
998:
995:
993:
990:
988:
985:
983:
980:
978:
975:
973:
970:
969:
967:
965:(EC 2.7.11.1)
964:
960:
956:
951:
946:
942:
937:
933:
929:
922:
917:
915:
910:
908:
903:
902:
899:
890:
886:
881:
876:
872:
868:
864:
859:
855:
851:
846:
841:
837:
833:
832:J. Biol. Chem
829:
824:
820:
816:
812:
808:
805:(1): 144–51.
804:
800:
795:
791:
787:
782:
777:
773:
769:
765:
761:
757:
752:
748:
744:
739:
734:
730:
726:
722:
718:
714:
709:
705:
701:
696:
691:
687:
683:
682:J. Biol. Chem
679:
674:
673:
668:
659:
655:
651:
647:
643:
639:
636:(1): 241–58.
635:
631:
624:
621:
616:
612:
607:
602:
597:
592:
588:
584:
581:(7): e41171.
580:
576:
572:
565:
562:
557:
553:
548:
543:
538:
533:
529:
525:
521:
514:
512:
508:
503:
499:
494:
489:
485:
481:
477:
473:
469:
462:
460:
456:
451:
447:
442:
437:
432:
427:
423:
419:
415:
408:
405:
400:
396:
392:
388:
384:
380:
376:
372:
368:
364:
357:
354:
347:
345:
339:
337:
334:
327:
325:
318:
316:
313:
309:
305:
301:
297:
293:
289:
281:
279:
277:
273:
269:
265:
261:
233:
232:
231:
229:
225:
221:
217:
214:
210:
206:
193:
190:
188:
184:
181:
178:
176:
172:
169:
166:
164:
160:
155:
151:
148:
144:
141:
139:
138:Gene Ontology
135:
132:
129:
126:
123:
120:
116:
113:
110:
108:
104:
101:
98:
96:
92:
89:
86:
84:
80:
77:
76:NiceZyme view
74:
72:
68:
65:
62:
60:
56:
53:
50:
48:
44:
39:
36:
33:
31:
27:
22:
17:
3142:EC 2.7 stubs
3087:expanding it
3073:
3065:
3027:Translocases
3024:
3011:
2998:
2985:
2972:
2962:Transferases
2959:
2946:
2803:Binding site
2234:P70S6 kinase
1987:
870:
866:
835:
831:
802:
798:
763:
759:
720:
716:
685:
681:
633:
629:
623:
578:
574:
564:
527:
523:
475:
472:Biochemistry
471:
421:
417:
407:
366:
362:
356:
343:
335:
331:
322:
302:residues in
288:transferases
285:
282:Nomenclature
257:
208:
202:
64:BRENDA entry
2798:Active site
2685:(EC 2.7.12)
2072:Polo kinase
2012:Polo kinase
873:(1): 26–9.
52:IntEnz view
24:Identifiers
3126:Categories
3001:Isomerases
2975:Hydrolases
2842:Regulation
1363:IÎşB kinase
938:2.7.11-12)
717:Biochem. J
348:References
328:Activation
260:substrates
205:enzymology
121:structures
88:KEGG entry
3132:EC 2.7.11
2880:EC number
1489:PKC alpha
867:FEBS Lett
630:Apoptosis
300:threonine
242:⇌
224:catalyzes
216:2.7.11.20
41:Databases
35:2.7.11.20
2904:Kinetics
2828:Cofactor
2791:Activity
1845:KIAA0999
1740:MAPKAPK5
1735:MAPKAPK3
1730:MAPKAPK2
889:11904175
854:14709557
819:15158453
790:11500363
658:16393302
650:24193916
615:22911754
575:PLOS ONE
556:25012662
502:22329831
450:24574971
319:Function
310:). The
304:proteins
294:atom of
272:products
218:) is an
192:proteins
180:articles
168:articles
125:RCSB PDB
3060:Biology
3014:Ligases
2784:Enzymes
2504:MAP3K14
2482:MAP3K11
2477:MAP3K10
2467:MAP3K13
2462:MAP3K12
2264:RPS6KC1
2259:RPS6KA1
2254:RPS6KA3
2249:RPS6KA2
2244:RPS6KB2
2229:RPS6KA4
2224:RPS6KA5
1875:Kalirin
1840:SNF1LK2
1079:EIF2AK4
1074:EIF2AK3
928:Kinases
747:1372803
738:1130869
704:8514778
606:3401164
583:Bibcode
547:4156036
493:3401519
441:3918593
399:4246244
391:3386756
371:Bibcode
234:ATP +
147:QuickGO
112:profile
95:MetaCyc
3079:enzyme
3076:EC 2.7
3046:Portal
2988:Lyases
2734:MAP2K7
2729:MAP2K6
2724:MAP2K5
2719:MAP2K4
2714:MAP2K3
2709:MAP2K2
2704:MAP2K1
2655:ACVRL1
2650:ACVR2B
2645:ACVR2A
2640:ACVR1C
2635:ACVR1B
2618:BMPR1B
2613:BMPR1A
2487:MAP3K7
2472:MAP3K9
2423:MAP3K8
2418:MAP3K7
2413:MAP3K6
2408:MAP3K5
2403:MAP3K4
2398:MAP3K3
2393:MAP3K2
2388:MAP3K1
2362:MAPK14
2357:MAPK13
2352:MAPK11
2340:MAPK10
2318:MAPK15
2313:MAPK12
2205:CDC2L1
2180:CDC2L5
1855:SNF1LK
1680:CAMK2G
1675:CAMK2D
1670:CAMK2B
1665:CAMK2A
1655:CAMK1G
1650:CAMK1D
1645:CAMK1B
1640:CAMK1A
1494:PRKCB1
1431:PRKACA
1426:PRKACB
1421:PRKACG
1397:IKBKAP
1223:BCKDHB
1218:BCKDHA
1192:PRKAG3
1187:PRKAG2
1182:PRKAG1
1172:PRKAB2
1167:PRKAB1
1157:PRKAA2
1152:PRKAA1
997:STK38L
887:
852:
817:
788:
781:125581
778:
760:EMBO J
745:
735:
702:
656:
648:
613:
603:
554:
544:
500:
490:
448:
438:
424:: 35.
397:
389:
363:Nature
340:Cancer
296:serine
292:oxygen
220:enzyme
175:PubMed
157:Search
143:AmiGO
131:PDBsum
71:ExPASy
59:BRENDA
47:IntEnz
30:EC no.
3074:This
2940:Types
2696:MAP2K
2630:ACVR1
2623:BMPR2
2608:BMPR1
2533:GSK-3
2374:MAP3K
2335:MAPK9
2330:MAPK8
2308:MAPK7
2303:MAPK6
2298:MAPK4
2293:MAPK3
2288:MAPK1
2200:PFTK1
2195:PCTK3
2190:PCTK2
2185:PCTK1
2175:CDK12
2170:CDK10
2145:CDKL5
2125:CDKL2
2002:STK19
1997:EEF2K
1978:PHKG2
1973:PHKG1
1963:PHKA2
1958:PHKA1
1939:MYLK4
1934:MYLK3
1929:MYLK2
1905:DCLK1
1900:Titin
1890:TRIB3
1885:TRIB2
1880:TRIB1
1870:TSSK2
1850:STK40
1835:PSKH1
1830:PRKD3
1825:PRKD2
1805:PHKG2
1800:PHKG1
1790:OBSCN
1785:NUAK2
1780:NUAK1
1775:MKNK2
1770:MKNK1
1760:MARK4
1755:MARK3
1750:MARK2
1745:MARK1
1725:STK11
1720:DAPK3
1715:DAPK2
1710:DAPK1
1705:CHEK2
1700:CHEK1
1685:CAMK4
1660:CAMK2
1635:CAMK1
1630:BRSK2
1524:PRKCQ
1519:PRKCI
1514:PRKCG
1509:PRKCH
1504:PRKCE
1499:PRKCD
1460:PRKG1
1392:IKBKG
1387:IKBKE
1336:STK10
1331:FASTK
1257:IDH3G
1252:IDH3B
1247:IDH3A
1213:BCKDK
1007:ROCK1
992:STK38
987:MAST2
982:MAST1
977:LATS2
972:LATS1
654:S2CID
395:S2CID
222:that
207:, an
107:PRIAM
3083:stub
3032:list
3025:EC7
3019:list
3012:EC6
3006:list
2999:EC5
2993:list
2986:EC4
2980:list
2973:EC3
2967:list
2960:EC2
2954:list
2947:EC1
2523:TPK1
2499:CDC7
2457:MLKs
2450:KSR2
2445:KSR1
2440:BRAF
2435:ARAF
2430:RAFs
2165:CDK9
2160:CDK8
2155:CDK7
2150:CDK6
2140:CDK5
2135:CDK4
2130:CDK3
2120:CDK2
2115:CDK1
2096:PLK4
2091:PLK3
2086:PLK2
2081:PLK1
2036:PLK4
2031:PLK3
2026:PLK2
2021:PLK1
1968:PHKB
1924:MYLK
1895:TRIO
1865:SPEG
1860:SNRK
1820:PKD1
1815:PIM2
1810:PIM1
1795:PASK
1765:MELK
1695:CASK
1690:MLCK
1611:GRK6
1606:GRK5
1601:GRK4
1539:PKN3
1534:PKN2
1436:PRKY
1382:TBK1
1377:IKK2
1372:CHUK
1276:STK4
1242:IDH2
1127:PDK4
1122:PDK3
1117:PDK2
1112:PDK1
1091:WEE1
1086:Wee1
1054:mTOR
1042:AKT3
1037:AKT2
1032:AKT1
1022:SGK3
1017:SGK2
885:PMID
850:PMID
815:PMID
786:PMID
743:PMID
700:PMID
646:PMID
611:PMID
552:PMID
498:PMID
446:PMID
387:PMID
274:are
266:and
226:the
187:NCBI
128:PDBe
83:KEGG
2528:TTK
2492:ZAK
1069:HRI
1064:PKR
1012:SGK
1002:CIT
875:doi
871:514
840:doi
836:279
807:doi
803:319
776:PMC
768:doi
733:PMC
725:doi
721:282
690:doi
686:268
638:doi
601:PMC
591:doi
542:PMC
532:doi
528:289
488:PMC
480:doi
436:PMC
426:doi
379:doi
367:334
298:or
264:ATP
203:In
163:PMC
119:PDB
3128::
1178:Îł
1163:β
1148:α
936:EC
930::
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