209:
208:
220:(c,d) 400× g magnified image plus zoom of diagnostic round cystic Schiller–Duval body in a transverse section, with microcystic and papillary patterns around. The body has a central vessel surrounded by fibrous tissue, called the fibrovascular core, and it is surrounded by layers of the tumoral cells at the surface of that stalk. The structure is located in open cystic space also lined by tumoral cells. All those structures together are called a Schiller–Duval body and resemble primitive glomerulus. H&E stain.
78:
47:
264:
has been described. Before modern chemotherapy, this type of neoplasm was highly lethal, but the prognosis has significantly improved since then. When endodermal sinus tumors are treated promptly with surgery and chemotherapy, fatal outcomes are exceedingly rare.
185:
is complicated by the extremely high levels of AFP in those two groups. Tumor surveillance by monitoring AFP requires accurate correction for gestational age in pregnant women, and age in infants. In pregnant women, this can be achieved simply by testing
677:
106:. This age group has a very good prognosis. In contrast to the pure form typical of infants, adult endodermal sinus tumors are often found in combination with other kinds of germ cell tumor, particularly
202:
EST can have a multitude of morphologic patterns including: reticular, endodermal sinus-like, microcystic, papillary, solid, glandular, alveolar, polyvesicular vitelline, enteric and hepatoid.
689:
166:
and AFP test results for EST, the result indicating presence of EST dictates treatment. This is because EST often occurs as small "malignant foci" within a larger tumor, usually
958:
1484:
508:
1658:
1653:
528:
Bhatt MD, Braga LH, Stein N, Terry J, Portwine C (July 2015). "Vaginal Yolk Sac Tumor in an Infant: A Case Report and
Literature Review of the Last 30 Years".
361:
Luther N, Edgar MA, Dunkel IJ, Souweidane MM (Aug 2006). "Correlation of endoscopic biopsy with tumor marker status in primary intracranial germ cell tumors".
1322:
598:
Motegi M, Takakura S, Takano H, Tanaka T, Ochiai K (February 2007). "Adjuvant chemotherapy in a pregnant woman with endodermal sinus tumor of the ovary".
796:
1398:
1307:
170:, and biopsy is a sampling method; biopsy of the tumor may reveal only teratoma, whereas elevated AFP reveals that EST is also present. GATA-4, a
951:
1388:
1279:
340:
1477:
1116:
405:
1518:
1078:
514:- "This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (
1665:
1317:
1034:
700:
1302:
913:
582:
1403:
1345:
944:
896:
571:
Coran, Arnold G.; Caldamone, Anthony; Adzick, N. Scott; Krummel, Thomas M.; Laberge, Jean-Martin; Shamberger, Robert (2012-01-25).
1446:
1002:
194:. In infants, the tumor marker test is used, but must be interpreted using a reference table or graph of normal AFP in infants.
1741:
1698:
1470:
1441:
1528:
1096:
1751:
789:
218:(b) marked tubulopapillary sinusoidal structure with central vascular core in longitudinal section (Schiller–Duval body);
1766:
1284:
1059:
216:(a) papillary pattern combined with small tubopapillary endodermal sinus structure (Schiller–Duval body) in blue circle;
997:
1756:
1675:
1577:
1746:
1019:
1720:
1451:
782:
319:
Hari, Anil; Grossfeld, Gary; Hricak, Hedvig (2002-01-01), Bragg, David G.; Rubin, Philip; Hricak, Hedvig (eds.),
1715:
1274:
711:
1366:
225:
1426:
1312:
892:
404:
Siltanen S, Anttonen M, Heikkilä P, Narita N, Laitinen M, Ritvos O, Wilson DB, Heikinheimo M (Dec 1999).
1761:
1436:
1202:
1106:
762:
502:
443:
46:
1670:
1024:
320:
236:
and seen in the context of the endodermal sinus-like pattern. Rarely, it can be found in the vagina.
171:
77:
1597:
1572:
1533:
1144:
1091:
851:
151:
111:
457:
Fischerova D, Indrielle-Kelly T, Burgetova A, Bennett RJ, Gregova M, Dundr P; et al. (2022).
1710:
1538:
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1086:
1054:
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1705:
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191:
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143:
66:
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1139:
1126:
908:
901:
843:
813:
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641:
274:
95:
1462:
936:
142:
of EST is variable, but usually includes malignant endodermal cells. These cells secrete
1648:
1607:
1380:
1246:
1224:
1154:
1064:
988:
925:
694:
611:
485:
458:
430:
159:
102:. It is the most common testicular tumor in children under three, and is also known as
421:
1735:
1693:
1685:
1418:
1408:
1163:
880:
867:
332:
233:
627:
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831:
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58:
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54:
821:
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261:
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139:
119:
619:
549:
494:
439:
382:
1622:
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1431:
1332:
1159:
863:
826:
757:
167:
107:
71:
31:
669:
1111:
1101:
406:"Transcription Factor GATA-4 Is Expressed in Pediatric Yolk Sac Tumors"
245:
681:
182:
163:
115:
99:
459:"Yolk Sac Tumor of the Omentum: A Case Report and Literature Review"
214:
Histopathology of endodermal sinus tumor with
Schiller–Duval bodies.
774:
967:
155:
738:
705:
1466:
940:
778:
57:
showing the yolk sac component of a mixed germ cell tumour.
659:
1684:
1639:
1588:
1558:
1549:
1517:
1508:
1417:
1379:
1354:
1331:
1293:
1260:
1232:
1223:
1201:
1179:
1125:
1077:
1012:
996:
987:
978:
842:
812:
748:
663:
65:
26:
21:
642:Prepubertal Testicular and Paratesticular Tumors
1654:High-grade prostatic intraepithelial neoplasia
174:, also may be useful in the diagnosis of EST.
146:(AFP), which can be detected in tumor tissue,
130:Causes for this cancer are poorly understood.
1478:
952:
790:
8:
516:https://creativecommons.org/licenses/by/4.0/
507:: CS1 maint: multiple names: authors list (
244:Most treatments involve some combination of
1555:
1514:
1485:
1471:
1463:
1229:
1009:
993:
984:
959:
945:
937:
797:
783:
775:
660:
76:
45:
18:
484:
474:
429:
530:Journal of Pediatric Hematology/Oncology
1399:Clear-cell adenocarcinoma of the vagina
291:
204:
158:and, in the rare case of fetal EST, in
500:
327:, Oxford: Elsevier, pp. 603–628,
1389:Squamous-cell carcinoma of the vagina
1280:Endometrial intraepithelial neoplasia
857:Endodermal sinus tumor/Yolk sac tumor
162:. When there is incongruence between
7:
1117:Sex cord tumour with annular tubules
321:"Chapter 29 - Tumors of the Scrotum"
1666:List of people with prostate cancer
1035:Papillary serous cystadenocarcinoma
1303:Cervical intraepithelial neoplasia
1275:Uterine papillary serous carcinoma
914:Placental site trophoblastic tumor
612:10.1097/01.AOG.0000245450.62758.47
14:
1404:Vaginal intraepithelial neoplasia
1346:Gestational trophoblastic disease
897:Gestational trophoblastic disease
114:. While pure teratoma is usually
1447:Vulvar intraepithelial neoplasia
207:
333:10.1016/b0-72-167494-1/50032-3
1:
1323:Villoglandular adenocarcinoma
422:10.1016/S0002-9440(10)65500-9
410:American Journal of Pathology
104:infantile embryonal carcinoma
1699:Extramammary Paget's disease
1442:Extramammary Paget's disease
1285:Uterine clear-cell carcinoma
1060:Ovarian clear-cell carcinoma
577:. Elsevier Health Sciences.
542:10.1097/MPH.0000000000000325
118:, endodermal sinus tumor is
1676:Transitional-cell carcinoma
1578:Germ cell neoplasia in situ
476:10.3390/diagnostics12020304
1788:
1529:Sertoli–Leydig cell tumour
1242:Uterine fibroids/leiomyoma
1097:Sertoli–Leydig cell tumour
1020:Ovarian serous cystadenoma
1721:Hirsuties coronae glandis
1452:Bartholin gland carcinoma
1394:Botryoid rhabdomyosarcoma
1050:
600:Obstetrics and Gynecology
375:10.1007/s11060-005-9110-0
363:Journal of Neuro-Oncology
53:
44:
1716:Erythroplasia of Queyrat
1079:Sex cord–gonadal stromal
998:Glandular and epithelial
574:Pediatric Surgery E-Book
300:"Endodermal Sinus Tumor"
1742:Male genital neoplasia
1603:Endodermal sinus tumor
1150:Endodermal sinus tumor
893:Trophoblastic neoplasm
88:Endodermal sinus tumor
22:Endodermal sinus tumor
1752:Gynaecological cancer
1437:Papillary hidradenoma
1367:Mixed MĂĽllerian tumor
1318:Glassy-cell carcinoma
1107:Granulosa cell tumour
226:Schiller–Duval bodies
94:) is a member of the
1671:Small-cell carcinoma
1308:Clear-cell carcinoma
1025:Mucinous cystadenoma
177:Diagnosis of EST in
172:transcription factor
1767:Germ cell neoplasia
1598:Embryonal carcinoma
1573:Spermatocytic tumor
1534:Sertoli cell tumour
1145:Embryonal carcinoma
1092:Sertoli cell tumour
1003:surface epithelial-
852:Embryonal carcinoma
152:cerebrospinal fluid
112:embryonal carcinoma
1757:Colorectal surgery
1711:Bowenoid papulosis
1539:Leydig cell tumour
1270:Endometrioid tumor
1087:Leydig cell tumour
1055:Endometrioid tumor
1030:Cystadenocarcinoma
749:External resources
188:maternal serum AFP
1747:Pediatric cancers
1729:
1728:
1635:
1634:
1631:
1630:
1500:urogenital system
1460:
1459:
1375:
1374:
1219:
1218:
1211:Adenomatoid tumor
1197:
1196:
1073:
1072:
972:urogenital system
934:
933:
902:Hydatidiform mole
886:Strumal carcinoid
772:
771:
606:(2 Pt2): 537–40.
342:978-0-7216-7494-0
325:Oncologic Imaging
280:Testicular cancer
252:. Treatment with
144:alpha-fetoprotein
85:
84:
16:Medical condition
1779:
1556:
1515:
1487:
1480:
1473:
1464:
1230:
1140:Nongerminomatous
1042:Krukenberg tumor
1010:
994:
985:
961:
954:
947:
938:
844:Nongerminomatous
806:Germ cell tumors
799:
792:
785:
776:
661:
649:
638:
632:
631:
595:
589:
588:
568:
562:
561:
525:
519:
512:
506:
498:
488:
478:
454:
448:
447:
442:. Archived from
433:
401:
395:
394:
358:
352:
351:
350:
349:
316:
310:
309:
307:
306:
296:
211:
192:tumor marker AFP
81:
80:
49:
19:
1787:
1786:
1782:
1781:
1780:
1778:
1777:
1776:
1732:
1731:
1730:
1725:
1706:Bowen's disease
1680:
1627:
1618:Choriocarcinoma
1584:
1545:
1521:gonadal stromal
1520:
1504:
1491:
1461:
1456:
1413:
1371:
1362:Uterine sarcoma
1350:
1341:Choriocarcinoma
1327:
1289:
1256:
1215:
1193:
1189:Meigs' syndrome
1175:
1169:Choriocarcinoma
1121:
1069:
1046:
1004:
1001:
974:
965:
935:
930:
909:Choriocarcinoma
838:
808:
803:
773:
768:
767:
744:
743:
672:
658:
653:
652:
639:
635:
597:
596:
592:
585:
570:
569:
565:
527:
526:
522:
513:
499:
456:
455:
451:
403:
402:
398:
360:
359:
355:
347:
345:
343:
318:
317:
313:
304:
302:
298:
297:
293:
288:
275:Germ cell tumor
271:
242:
221:
219:
217:
215:
212:
200:
136:
128:
96:germ cell tumor
75:
17:
12:
11:
5:
1785:
1783:
1775:
1774:
1769:
1764:
1759:
1754:
1749:
1744:
1734:
1733:
1727:
1726:
1724:
1723:
1718:
1713:
1708:
1703:
1702:
1701:
1690:
1688:
1682:
1681:
1679:
1678:
1673:
1668:
1663:
1662:
1661:
1651:
1649:Adenocarcinoma
1645:
1643:
1637:
1636:
1633:
1632:
1629:
1628:
1626:
1625:
1620:
1615:
1610:
1608:Gonadoblastoma
1605:
1600:
1594:
1592:
1586:
1585:
1583:
1582:
1581:
1580:
1575:
1564:
1562:
1553:
1547:
1546:
1544:
1543:
1542:
1541:
1536:
1525:
1523:
1512:
1506:
1505:
1503:
1502:
1492:
1490:
1489:
1482:
1475:
1467:
1458:
1457:
1455:
1454:
1449:
1444:
1439:
1434:
1429:
1423:
1421:
1415:
1414:
1412:
1411:
1406:
1401:
1396:
1391:
1385:
1383:
1377:
1376:
1373:
1372:
1370:
1369:
1364:
1358:
1356:
1352:
1351:
1349:
1348:
1343:
1337:
1335:
1329:
1328:
1326:
1325:
1320:
1315:
1310:
1305:
1299:
1297:
1291:
1290:
1288:
1287:
1282:
1277:
1272:
1266:
1264:
1258:
1257:
1255:
1254:
1249:
1247:Leiomyosarcoma
1244:
1238:
1236:
1227:
1221:
1220:
1217:
1216:
1214:
1213:
1207:
1205:
1203:Fallopian tube
1199:
1198:
1195:
1194:
1192:
1191:
1185:
1183:
1177:
1176:
1174:
1173:
1172:
1171:
1166:
1157:
1155:Gonadoblastoma
1152:
1147:
1137:
1131:
1129:
1123:
1122:
1120:
1119:
1114:
1109:
1104:
1099:
1094:
1089:
1083:
1081:
1075:
1074:
1071:
1070:
1068:
1067:
1065:Brenner tumour
1062:
1057:
1051:
1048:
1047:
1045:
1044:
1039:
1038:
1037:
1027:
1022:
1016:
1014:
1007:
991:
982:
976:
975:
970:of the female
966:
964:
963:
956:
949:
941:
932:
931:
929:
928:
926:Gonadoblastoma
923:
917:
916:
911:
906:
905:
904:
889:
888:
883:
878:
873:
860:
859:
854:
848:
846:
840:
839:
837:
836:
835:
834:
829:
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779:
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750:
746:
745:
742:
741:
730:
719:
708:
697:
686:
673:
668:
667:
665:
664:Classification
657:
656:External links
654:
651:
650:
633:
590:
584:978-0323091619
583:
563:
536:(5): e336–40.
520:
449:
446:on 2009-03-16.
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179:pregnant women
160:amniotic fluid
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1438:
1435:
1433:
1430:
1428:
1425:
1424:
1422:
1420:
1416:
1410:
1409:Vaginal cysts
1407:
1405:
1402:
1400:
1397:
1395:
1392:
1390:
1387:
1386:
1384:
1382:
1378:
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1204:
1200:
1190:
1187:
1186:
1184:
1182:
1178:
1170:
1167:
1165:
1164:Struma ovarii
1161:
1158:
1156:
1153:
1151:
1148:
1146:
1143:
1142:
1141:
1138:
1136:
1133:
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1128:
1124:
1118:
1115:
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1108:
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1098:
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1076:
1066:
1063:
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1058:
1056:
1053:
1052:
1049:
1043:
1040:
1036:
1033:
1032:
1031:
1028:
1026:
1023:
1021:
1018:
1017:
1015:
1011:
1008:
1006:
1005:stromal tumor
999:
995:
992:
990:
986:
983:
981:
977:
973:
969:
962:
957:
955:
950:
948:
943:
942:
939:
927:
924:
922:
919:
918:
915:
912:
910:
907:
903:
900:
899:
898:
894:
891:
890:
887:
884:
882:
881:Struma ovarii
879:
877:
874:
872:
871:
865:
862:
861:
858:
855:
853:
850:
849:
847:
845:
841:
833:
830:
828:
825:
824:
823:
820:
819:
817:
815:
814:Germinomatous
811:
807:
800:
795:
793:
788:
786:
781:
780:
777:
764:
760:
759:
755:
754:
751:
747:
740:
736:
735:
731:
729:
725:
724:
720:
718:
714:
713:
709:
707:
703:
702:
698:
696:
692:
691:
687:
684:
683:
679:
675:
674:
671:
666:
662:
655:
648:
644:
643:
637:
634:
629:
625:
621:
617:
613:
609:
605:
601:
594:
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25:
20:
1762:Rare cancers
1602:
1498:of the male
1149:
1135:Dysgerminoma
921:Polyembryoma
876:Dermoid cyst
869:
856:
832:Dysgerminoma
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732:
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685:: C56 C62.9
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346:, retrieved
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303:. Retrieved
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250:chemotherapy
243:
224:
201:
190:rather than
176:
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91:
87:
86:
37:
30:
1262:Endometrium
463:Diagnostics
27:Other names
1736:Categories
1252:Adenomyoma
1234:Myometrium
723:DiseasesDB
469:(2): 304.
348:2020-10-21
305:2018-10-10
286:References
55:Micrograph
1694:Carcinoma
1551:Germ cell
1519:Sex cord–
1510:Testicles
1127:Germ cell
868:Fetus in
822:Germinoma
734:SNOMED CT
647:eMedicine
262:bleomycin
258:etoposide
254:cisplatin
240:Treatment
230:histology
198:Pathology
140:histology
134:Diagnosis
120:malignant
98:group of
67:Specialty
1772:Endoderm
1641:Prostate
1623:Embryoma
1613:Teratoma
1568:Seminoma
1432:Melanoma
1333:Placenta
1160:Teratoma
864:Teratoma
827:Seminoma
758:Orphanet
739:74409009
628:24159507
620:17267887
550:25851552
495:35204394
440:10595911
391:19124218
383:16598424
269:See also
168:teratoma
108:teratoma
72:Oncology
32:Yolk sac
1355:General
1181:Fibroma
1112:Luteoma
1102:Thecoma
989:Ovaries
717:D018240
695:M9071/3
558:7605939
486:8871053
431:1866939
246:surgery
183:infants
181:and in
100:cancers
1496:Tumors
1381:Vagina
1295:Cervix
1225:Uterus
980:Adnexa
968:Tumors
706:273300
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260:, and
164:biopsy
116:benign
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1686:Penis
1659:HGPIN
1419:Vulva
690:ICD-O
624:S2CID
554:S2CID
387:S2CID
156:urine
148:serum
126:Cause
34:tumor
1013:CMS:
870:fetu
728:4248
712:MeSH
701:OMIM
616:PMID
579:ISBN
546:PMID
509:link
491:PMID
436:PMID
379:PMID
337:ISBN
248:and
232:are
138:The
110:and
1427:SCC
1313:SCC
763:876
678:ICD
645:at
608:doi
604:109
538:doi
518:)."
481:PMC
471:doi
426:PMC
418:doi
414:155
371:doi
329:doi
228:on
92:EST
38:YST
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