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Eperisone

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may occur. In the event of such symptoms, the dosage should be reduced or treatment discontinued. Patients should be cautioned against engaging in potentially hazardous activities requiring alertness, such as operating machinery or driving a car.
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to the drug. Side effects: 'very rare' excessive relaxation, stomachache, nausea, vertigo, anorexia, drowsiness, skin rashes, diarrhoea, vomiting, indigestion, GI disturbances, insomnia, headache, constipation etc.
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Tanno K, Narimatsu E, Takeyama Y, Asai Y (May 2007). "Infantile case of seizure induced by intoxication after accidental consumption of eperisone hydrochloride, an antispastic agent".
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Yang SI, Park HY, Lee SH, Lee SJ, Han OY, Lim SC, et al. (July 2004). "Transdermal eperisone elicits more potent and longer-lasting muscle relaxation than oral eperisone".
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Yang SI, Park HY, Lee SH, Lee SJ, Han OY, Lim SC, et al. (July 2004). "Transdermal eperisone elicits more potent and longer-lasting muscle relaxation than oral eperisone".
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patients are treated with eperisone, a reduced dose is recommended, and the patient should be closely monitored for signs of physiological hypofunction during treatment.
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Bose K (April 1999). "The efficacy and safety of eperisone in patients with cervical spondylosis: results of a randomized, double-blind, placebo-controlled trial".
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In adults, the usual dose of eperisone is 50–150 mg per day, in divided doses, after meals. However, the dosage is adjusted by the
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benefits will outweigh the possible risks associated with treatment. The manufacturers of Myonal recommend the drug not be used during
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system, has shown promising results in laboratory tests on rodents; however, this product is not currently available for human use.
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Eperisone should be administered with care in patients with a history of hypersensitivity to any medication, or with disorders of
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application of the drug and makes it an attractive choice for patients who require antispasmodic therapy without a reduction in
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for "Evaluation of Eperisone HCl in the Treatment of Acute Musculoskeletal Spasm Associated With Low Back Pain" at
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women; therefore the drug should not be used in pregnant women, or women who may be pregnant, if the expected
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InChI=1S/C17H25NO/c1-3-15-7-9-16(10-8-15)17(19)14(2)13-18-11-5-4-6-12-18/h7-10,14H,3-6,11-13H2,1-2H3
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Eperisone hydrochloride is available as the brand name preparations Myonal and Epry as 50 mg
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use, therefore its use in paediatrics cannot be recommended without further study.
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without reducing muscle power; it is therefore useful during the initial stage of
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Shock and anaphylactoid reactions: In the event of symptoms such as redness,
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have been reported in an infant after accidental ingestion of eperisone.
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Eperisone also facilitates voluntary movement of the upper and lower
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when compared with other antispasmodic drugs; this simplifies the
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Methods and Findings in Experimental and Clinical Pharmacology
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Inoue S, Bian K, Okamura T, Okunishi H, Toda N (July 1989).
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Eperisone has not been established as definitely safe for
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and as a supporting drug during subsequent rehabilitative
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The Journal of Pharmacology and Experimental Therapeutics
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Eperisone has not been established to be safe for use by
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Eperisone is marketed under many brand names worldwide.
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occurring after the concomitant use of the related drug
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containing eperisone is currently in development in
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in skeletal muscles, thus alleviating stiffness and
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Unsourced material may be challenged and removed. 955:function (it may aggravate hepatic dysfunction). 922:action and inhibition of the pain reflex in the 310: 285: 277: 1282: 1280: 1140:Chemically and mechanistically related drugs: 1668: 1120:agent, with promising results from trials on 724:in conditions such as cerebrovascular disease 8: 1116:Eperisone is also under investigation as an 677:Eperisone has a relatively low incidence of 121: 1059:There have been reports of disturbances in 232:In general: ℞ (Prescription only) 1941: 1722: 1713: 1675: 1661: 1653: 1510:The American Journal of Emergency Medicine 843:Safety during pregnancy and breast-feeding 469: 350: 138: 129: 1634: 995:of the face and other parts of the body, 821:depending on factors such as severity of 378: 370: 109:Learn how and when to remove this message 781:Cervical syndrome, periarthritis of the 2325:Drugs with unknown mechanisms of action 1592:Fujioka M, Kuriyama H (December 1985). 1232:"eperisone Summary Report - CureHunter" 1177: 1097:when taken orally, as a result of high 577: 557: 465: 330: 253: 1183: 1181: 120: 16:Antispasmodic and muscle relaxant drug 1552: Eperisone as a hypotensive agent 741:(including from cerebrospinal tumour) 438: 418: 171: 7: 1338: 1336: 1334: 1332: 206: 47:adding citations to reliable sources 655:, and facilitating muscle movement 398: 301: 1093:Eperisone suffers from a very low 14: 1623:Japanese Journal of Pharmacology 1563:"International eperisone brands" 627:Eperisone acts by relaxing both 504: 498: 23: 778:and other encephalomyelopathies 585:Key:SQUNAWUMZGQQJD-UHFFFAOYSA-N 34:needs additional citations for 1466:Ueno T, Kawana S (July 2007). 916:and augmentation of blood flow 560:CCc1ccc(cc1)C(=O)C(C)CN2CCCCC2 507: 492: 1: 760:Amyotrophic lateral sclerosis 696:Japanese package of eperisone 825:, patient age and response. 770:Spinocerebellar degeneration 1263:10.1358/mf.1999.21.3.534831 2341: 1522:10.1016/j.ajem.2006.09.002 482:Chemical and physical data 1902:Polyalkylene derivatives: 810:Dosage and administration 593: 568: 548: 244: 137: 128: 728:Spastic spinal paralysis 658:Eperisone also improves 173:International Drug Names 2315:1-Piperidinyl compounds 938:in patients with known 633:vascular smooth muscles 618:eperisone hydrochloride 1915:ACh release inhibitors 1797:intermediate duration: 1416:Clinical trial number 1344:"Myonal Tablets 50 mg" 697: 1766:ultra-short duration: 695: 2142:Arbaclofen placarbil 1835:Dimethyltubocurarine 1743:Dimethyltubocurarine 1002:Other side effects: 800:sugar-coated tablets 733:Cervical spondylosis 672:cervical spondylosis 43:improve this article 1889:Choline derivatives 1698:Peripherally acting 1089:Future developments 616:(formulated as the 125: 2053:Nonbenzodiazepines 1758:4° ammonium agents 1636:10.1254/jjp.50.271 1424:ClinicalTrials.gov 1325:. 17 October 2012. 1323:europeanreview.org 1236:www.curehunter.com 1078:Safety in overdose 1070:hydrochloride and 1034:, abdominal pain, 698: 2297: 2296: 2275: 2274: 1931: 1930: 1896:(Succinylcholine) 1874: 1873: 1388:10.1159/000077449 1202:10.1159/000077449 1107:transdermal patch 1055:Drug interactions 1044:urinary retention 930:Contraindications 804:transdermal patch 776:vascular diseases 722:Spastic paralysis 639:, improvement of 611: 610: 539:Interactive image 451:CompTox Dashboard 119: 118: 111: 93: 2332: 2320:Aromatic ketones 2310:Muscle relaxants 2252:Thiocolchicoside 2107:Anticholinergics 2071:Thienodiazepines 1942: 1937:Centrally acting 1867:(Hexafluorenium) 1723: 1718:Non-depolarizing 1714: 1685:muscle relaxants 1677: 1670: 1663: 1654: 1648: 1638: 1613: 1578: 1577: 1575: 1573: 1559: 1553: 1551: 1550: 1546: 1540: 1534: 1533: 1505: 1499: 1498: 1496: 1495: 1486:. Archived from 1463: 1457: 1456: 1454: 1453: 1447: 1441:. Archived from 1440: 1432: 1426: 1414: 1408: 1407: 1371: 1365: 1364: 1362: 1361: 1355: 1349:. Archived from 1348: 1340: 1327: 1326: 1315: 1309: 1308: 1306: 1305: 1299: 1293:. Archived from 1292: 1284: 1275: 1274: 1246: 1240: 1239: 1228: 1222: 1221: 1185: 1118:antihypertensive 963:light-headedness 940:hypersensitivity 907:sensitivity via 884:skeletal muscles 666:associated with 629:skeletal muscles 607: 606: 599: 541: 521: 509: 506: 500: 494: 474: 473: 459: 457: 442: 422: 402: 382: 374: 354: 334: 314: 304: 303: 289: 281: 210: 175: 142: 133: 126: 124: 114: 107: 103: 100: 94: 92: 51: 27: 19: 2340: 2339: 2335: 2334: 2333: 2331: 2330: 2329: 2300: 2299: 2298: 2293: 2281:Directly acting 2271: 2130: 2121:Cyclobenzaprine 2112:Antimuscarinics 2109: 2101: 2083: 2065: 2047: 2000:Benzodiazepines 1994: 1927: 1923:Botulinum toxin 1909: 1870: 1752: 1706: 1700: 1692: 1681: 1651: 1616: 1591: 1587: 1585:Further reading 1582: 1581: 1571: 1569: 1561: 1560: 1556: 1548: 1542: 1541: 1537: 1507: 1506: 1502: 1493: 1491: 1474:(in Japanese). 1465: 1464: 1460: 1451: 1449: 1445: 1438: 1434: 1433: 1429: 1415: 1411: 1373: 1372: 1368: 1359: 1357: 1353: 1346: 1342: 1341: 1330: 1317: 1316: 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84: 81: 77: 74: 70: 67: 63: 60: –  59: 55: 54:Find sources: 48: 44: 38: 37: 32:This article 30: 26: 21: 20: 2267:Zoxazolamine 2166: 2126:Orphenadrine 2097:Methaqualone 2089:Quinazolines 1960:Cyclarbamate 1955:Carisoprodol 1901: 1887: 1880:Depolarizing 1861: 1845:Pipecuronium 1826: 1796: 1780:Rapacuronium 1775: 1765: 1748:Tubocurarine 1626: 1622: 1601: 1597: 1570:. 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"Eperisone"
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Trade names
AHFS
Drugs.com
International Drug Names
Routes of
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Ora
ATC code
M03BX09
WHO
Legal status
IUPAC name
CAS Number
64840-90-0
56839-43-1
PubChem
3236
DrugBank

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