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InChI=1S/C30H31ClN4O4/c1-3-38-27-11-7-6-10-26(27)35-29(32-25-9-5-4-8-24(25)30(35)37)21(2)33-16-18-34(19-17-33)28(36)20-39-23-14-12-22(31)13-15-23/h4-15,21H,3,16-20H2,1-2H3
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514:"Pharmacological inhibition of cystine-glutamate exchange induces endoplasmic reticulum stress and ferroptosis"
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Erastin was first described in 2003. Its name is short for "eradicator of RAS and ST-expressing cells".
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Yagoda N, von
Rechenberg M, Zaganjor E, Bauer AJ, Yang WS, Fridman DJ, et al. (June 2007).
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Dixon SJ, Lemberg KM, Lamprecht MR, Skouta R, Zaitsev EM, Gleason CE, et al. (May 2012).
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Dixon SJ, Patel DN, Welsch M, Skouta R, Lee ED, Hayano M, et al. (May 2014).
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O=C1N(C2=CC=CC=C2OCC)C(C(C)N3CCN(C(COC4=CC=C(Cl)C=C4)=O)CC3)=NC5=CC=CC=C51
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2--1-piperazinyl]ethyl]-3-(2-ethoxyphenyl)-4(3H)-Quinazolinone
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Dolma S, Lessnick SL, Hahn WC, Stockwell BR (March 2003).
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may be too technical for most readers to understand
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355:(VDAC) by reversing tubulin's inhibition on
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16:Molecule initiating ferroptotic cell death
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62:Learn how and when to remove this message
46:, without removing the technical details.
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351:. Erastin binds and activates
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617:-related article is a
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376:glutathione
271: g·mol
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112:Identifiers
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524:: e02523.
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384:cell death
276:3D model (
264:Molar mass
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138:CAS Number
121:IUPAC name
52:April 2017
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372:cysteine
365:system X
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345:Erastin
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158:PubChem
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38:Please
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