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Feline foamy virus

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microtubules to its destination; the microtubule-organizing center. This is when early reverse transcription occurs. The foamy virus protease cuts the Gag protein and thus activates the viral core disassembly at the organizing center. Viral mRNAs and proteins are produced and the virions or complete viral particles gather in the cytoplasm of the cell. A retrieval signal from the cell's endoplasmic reticulum brings Env from the virion to the organelle. Without Env and GAG proteins, there is no foamy virus budding that occurs. Before budding occurs, later reverse transcription can take place, which results in 20% of the virions containing infectious DNA.
312:. There has been controversy on whether FeFV is nonpathogenic as the virus is generally asymptomatic in affected cats and does not cause disease. However, some changes in kidney and lung tissue have been observed over time in cats affected with FeFV, which may or may not be directly affiliated. This virus is fairly common and infection rates gradually increase with a cat's age. Study results from antibody examinations and PCR analysis have shown that over 70% of felines over 9 years old were seropositive for 137: 896: 2241: 1144: 1132: 25: 1168: 367: 1156: 388: 375:
aggressive behaviors in felines would account for many virus transmissions in wild cats while domesticated cats would be more apt to transmit the virus through licking. Cats who have been diagnosed with the virus are generally very healthy and go on to live normal lives, however if the cat also is infected with FIV (
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Felines infected with Feline foamy virus are often infected with FIV as well. FIV, also a retrovirus, will have more noticeable symptoms such as swollen joints, enlarged lymph nodes, and difficulty walking. Feline leukemia virus (FeLV) is another retrovirus that causes a common infectious disease in
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Many studies have been carried out with a number of foamy viruses and several mammals to better understand the viral replication strategies and viral genomes. With the increasing number of disease and the increasing number of discoveries linking diseases to genes, the future looks very promising in
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are commonly known to have a (+) single stranded RNA genome with a DNA intermediate. Typically, the virus will use its own reverse transcriptase enzyme to create DNA from the RNA genome. The FeFV viral genome is linear with (+) single stranded RNA or double stranded DNA depending on the timing of
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Currently, there is no treatment for felines with Feline Foamy Virus. However, ongoing studies are exploring the role of FeFV in viral gene therapy to treat other pathogenic feline diseases. Felines with FeFV often live long, healthy and disease free lives, which is of particular interest in the
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The host for FeFV is domestic and free-ranging felines. Although the major mode of transmission has not been specifically documented, FeFV has been identified in the saliva of many affected cats. Transmission has been hypothesized to occur through biting and grooming behaviors. The biting and
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To have a proper diagnosis, one must take one's cat to a veterinarian who will perform multiple blood tests to look for the antibodies for FeFV. This testing is not always available and can be rather expensive for the pet owner. Furthermore, there is such a small correlation between FeFV and
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Foamy viruses are unique and complex retroviruses with their viral replication strategies being different from conventional retroviruses. Foamy viruses have two bel genes, located between env and the 3 prime long terminal repeats of the FeFV provirus. A gag gene is also necessary for FeFV
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The foamy virus replication cycle begins when the virus attaches to an unknown cellular receptor. The virus has many long attachments or spikes (15 nm) that aid in the viral entry into various cell types in the host. Once inside the host cell, the viral core makes its way along the
345:(DNA genome) rather than conventional retroviruses (RNA genome). Some of these characteristics include the lack of a nucleocapsid protein and the equal binding affinity of the carboxyl-terminal portion of the GAG gene to DNA and RNA. 396:
felines by suppressing the immune system. The modes of transmission for FeLV include blood, saliva, urine, and milk. Kittens are very susceptible to Feline leukemia virus and can develop cancer as the disease progresses.
341:, which results in the viral particles containing DNA instead of RNA, it raises question to if this virus is actually considered a DNA virus or RNA virus. FeFV also has characteristics that are more consistent with 610:
Lee, IT; Levy, JK; Gorman, SP; Crawford, PC; Slater, MR (1 March 2002). "Prevalence of feline leukemia virus infection and serum antibodies against feline immunodeficiency virus in unowned free-roaming cats".
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disease that testing is not always useful. If an animal is showing symptoms such as those for polyarthritis, veterinarians might examine the joint fluid and treat the symptoms.
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Yu, SF; Baldwin, DN; Gwynn, SR; Yendapalli, S; Linial, ML (15 March 1996). "Human foamy virus replication: a pathway distinct from that of retroviruses and hepadnaviruses".
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reverse transcription as this process occurs later in the replication cycle of foamy viruses. This results in the infectious particles having DNA.
1567: 1206: 820: 316:. Viral infections are similar between male and female domesticated cats whereas in the wild, more feral females cats are affected with FeFV. 685:"Epidemiology of feline foamy virus and feline immunodeficiency virus infections in domestic and feral cats: a seroepidemiological study" 2195: 42: 598: 2102: 1592: 1607: 1562: 108: 89: 1172: 1636: 61: 2380: 46: 2092: 2087: 376: 68: 136: 2157: 1582: 1321: 2221: 2107: 2082: 1602: 1470: 1420: 75: 1577: 1199: 813: 526:
German, AC; Harbour, DA; Helps, CR; Gruffydd-Jones, TJ (15 May 2008). "Is feline foamy virus really apathogenic?".
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Grooming behavior in infected domesticated cats is thought to be one method of transmission of FeFV via saliva.
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Feline immunodeficiency virus genome – a retrovirus and associated disease to Feline foamy virus
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are enveloped and spherical shaped. They are 80-100 nm in diameter.
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Afonso, PV; Zamborlini, A; SaĂŻb, A; Mahieux, R (14 April 2007).
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scientific community in the use of viral gene therapy.
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Winkler, IG; Löchelt, M; Flower, RL (September 1999).
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Journal of the American Veterinary Medical Association
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International Committee on Taxonomy of Viruses (ICTV)
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Unsourced material may be challenged and removed. 557:"Foamy viruses are unconventional retroviruses" 1200: 814: 8: 2256: 1642: 1207: 1193: 1185: 821: 807: 799: 120: 708: 665: 580: 528:Veterinary Immunology and Immunopathology 508: 491:Erlwein, O; McClure, MO (December 2010). 473: 463: 109:Learn how and when to remove this message 1063:Laboratory diagnosis of viral infections 423:using foamy viruses for gene therapies. 765: 640:Ruboyianes, R; Worobey, M (July 2016). 1568:Associazione Nazionale Felina Italiana 599:"Feline Foamy Virus Infection in Cats" 7: 1155: 47:adding citations to reliable sources 1167: 1593:Governing Council of the Cat Fancy 14: 2053:Congenital sensorineural deafness 1608:The International Cat Association 1563:American Cat Fanciers Association 2240: 2239: 1588:FĂ©dĂ©ration Internationale FĂ©line 1166: 1154: 1143: 1142: 1130: 894: 689:Journal of Clinical Microbiology 135: 23: 701:10.1128/JCM.37.9.2848-2851.1999 573:10.1128/JVI.73.3.1747-1755.1999 34:needs additional citations for 1: 748:10.1126/science.271.5255.1579 377:Feline immunodeficiency virus 337:Because the virus has a late 540:10.1016/j.vetimm.2008.01.035 2222:List of longest-living cats 2103:Lower urinary tract disease 2083:Hypertrophic cardiomyopathy 1603:Southern Africa Cat Council 2402: 1578:Cat Aficionado Association 625:10.2460/javma.2002.220.620 288:and belongs to the family 2235: 2058:Feline corneal sequestrum 1583:Cat Fanciers' Association 1126: 892: 855:Social history of viruses 840: 555:Linial, ML (March 1999). 262: 255: 130: 123: 1573:Canadian Cat Association 774:"ICTV Taxonomy history: 2217:List of individual cats 309:Puma feline foamy virus 300:. It shares the genus 2093:Infectious peritonitis 2088:Immunodeficiency virus 1056:Helper dependent virus 465:10.1186/1742-4690-4-27 392: 371: 281:Feline syncytial virus 265:Feline syncytial virus 2381:Animal viral diseases 2158:Viral rhinotracheitis 2133:Tritrichomonas foetus 1598:New Zealand Cat Fancy 1466:Cats in ancient Egypt 390: 369: 362:Host and transmission 339:reverse transcription 1720:Colorpoint Shorthair 1618:World Cat Federation 1352:Cat–dog relationship 1108:Virus quantification 1103:Virus classification 320:Structure and genome 132:Virus classification 58:"Feline foamy virus" 43:improve this article 1920:Traditional Persian 1705:California Spangled 1675:Brazilian Shorthair 1471:Cultural depictions 1456:Cat-scratch disease 1098:Virus-like particle 740:1996Sci...271.1579Y 561:Journal of Virology 383:Associated diseases 284:(FeFV or FFV) is a 2300:Feline foamy virus 2270:Feline foamy virus 1840:Oriental Shorthair 1750:European Shorthair 1665:American Shorthair 1613:World Cat Congress 776:Feline foamy virus 510:10.1038/gt.2010.95 433:Feline vaccination 393: 372: 314:Feline foamy virus 294:and the subfamily 275:Feline foamy virus 248:Feline foamy virus 125:Feline foamy virus 2363: 2362: 2262:Taxon identifiers 2253: 2252: 2078:Hepatic lipidosis 1984: 1983: 1680:British Shorthair 1289:Tortoiseshell cat 1182: 1181: 1073:Neurotropic virus 918:Viral replication 734:(5255): 1579–82. 658:10.1093/ve/vew032 297:Spumaretrovirinae 271: 270: 119: 118: 111: 93: 2393: 2356: 2355: 2343: 2342: 2330: 2329: 2317: 2316: 2304: 2303: 2302: 2289: 2288: 2287: 2257: 2243: 2242: 2227:Cats in folklore 1825:Norwegian Forest 1795:Kurilian Bobtail 1775:Japanese Bobtail 1755:Exotic Shorthair 1643: 1508:National Cat Day 1265: 1209: 1202: 1195: 1186: 1170: 1169: 1158: 1157: 1146: 1145: 1134: 969:Phenotype mixing 905:Viral life cycle 898: 823: 816: 809: 800: 793: 792: 790: 788: 770: 759: 722: 712: 679: 669: 636: 606: 594: 584: 551: 522: 512: 487: 477: 467: 140: 139: 121: 114: 107: 103: 100: 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protein 884: 882: 879: 877: 874: 873: 871: 867: 861: 858: 856: 853: 851: 848: 846: 843: 842: 839: 835: 831: 824: 819: 817: 812: 810: 805: 804: 801: 783: 779: 777: 769: 766: 757: 753: 749: 745: 741: 737: 733: 729: 724: 720: 716: 711: 706: 702: 698: 694: 690: 686: 681: 677: 673: 668: 663: 659: 655: 652:(2): vew032. 651: 647: 643: 638: 634: 630: 626: 622: 618: 614: 608: 604: 600: 596: 592: 588: 583: 578: 574: 570: 566: 562: 558: 553: 549: 545: 541: 537: 533: 529: 524: 520: 516: 511: 506: 502: 498: 494: 489: 485: 481: 476: 471: 466: 461: 457: 453: 452:Retrovirology 449: 444: 443: 438: 434: 431: 430: 426: 424: 417: 415: 408: 406: 399: 397: 389: 382: 380: 378: 368: 361: 359: 355: 354:replication. 348: 346: 344: 340: 335: 332: 328: 326: 319: 317: 315: 311: 310: 305: 304: 299: 298: 293: 292: 287: 283: 282: 277: 276: 267: 266: 261: 258: 254: 250: 249: 244: 241: 240: 237: 236: 232: 229: 228: 225: 224: 220: 217: 216: 213: 212: 208: 205: 204: 201: 200: 196: 193: 192: 189: 188: 184: 181: 180: 177: 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Retrieved 781: 775: 768: 731: 727: 692: 688: 649: 645: 619:(5): 620–2. 616: 612: 602: 564: 560: 531: 527: 500: 497:Gene Therapy 496: 455: 451: 421: 418:Gene therapy 412: 403: 394: 373: 356: 352: 336: 331:Retroviruses 329: 325:Spumaviruses 323: 313: 307: 301: 295: 291:Retroviridae 289: 280: 279: 274: 273: 272: 264: 263: 247: 246: 234: 223:Retroviridae 222: 211:Ortervirales 210: 198: 186: 175:Pararnavirae 174: 162: 155: 145:(unranked): 124: 105: 96: 86: 79: 72: 65: 53: 41:Please help 36:verification 33: 2294:Wikispecies 2191:New Zealand 2118:Polydactyly 2048:Calicivirus 1940:Turkish Van 1880:Selkirk Rex 1835:Ojos Azules 1725:Cornish Rex 1533:Library cat 1518:Working cat 1446:Cat massage 1441:Cat killers 1423:interaction 1334:Vaccination 1269:Bicolor cat 1173:WikiProject 1041:Giant virus 1020:Plant virus 938:Lytic cycle 913:Viral entry 349:Replication 2370:Categories 2113:Giardiasis 1966:Highlander 1865:Ragamuffin 1805:Maine Coon 1785:Khao Manee 1765:German Rex 1655:Abyssinian 1555:Registries 1538:Ship's cat 1523:Bodega cat 1279:Calico cat 1224:Felinology 1118:Virosphere 1093:Viral load 1083:Satellites 869:Components 787:10 January 439:References 306:with only 286:retrovirus 69:newspapers 2285:Q18964933 2176:Australia 2138:Roundworm 2073:Heartworm 2030:disorders 1990:Landraces 1976:Serengeti 1925:Tonkinese 1895:Singapura 1855:Pixie-bob 1850:Peterbald 1770:Himalayan 1735:Devon Rex 1710:Chartreux 1631:full list 1493:Feral cat 1476:fictional 1436:Cat cafĂ©s 1421:Human–cat 1312:Declawing 1284:Tabby cat 1274:Black cat 1242:Dwarf cat 1078:Oncovirus 1015:Mycovirus 1005:Virophage 928:Viroplasm 603:petMD LLC 409:Treatment 400:Diagnosis 242:Species: 170:Kingdom: 163:Riboviria 2340:11459797 2279:Wikidata 2245:Category 2128:Ringworm 2068:Coccidia 1971:Savannah 1900:Snowshoe 1890:Siberian 1815:Munchkin 1780:Javanese 1700:Burmilla 1670:Balinese 1648:domestic 1545:Zoonosis 1528:Farm cat 1481:Internet 1461:Cat show 1451:Cat meat 1391:Kneading 1367:valerian 1357:Catfight 1344:Behavior 1257:Squitten 1237:Genetics 1149:Category 952:Genetics 860:Virology 719:10449463 676:28058112 633:12418520 548:18342375 519:20631802 484:17433108 427:See also 257:Synonyms 218:Family: 182:Phylum: 2210:Related 1961:Chausie 1885:Siamese 1860:Ragdoll 1845:Persian 1740:Donskoy 1695:Burmese 1513:Pet cat 1232:Anatomy 1161:Commons 988:By host 845:History 756:8599113 736:Bibcode 728:Science 667:5210030 591:9971751 475:1855351 230:Genus: 206:Order: 194:Class: 83:scholar 2327:539996 2181:Canada 2123:Rabies 2043:Asthma 2013:Sokoke 2008:Kellas 2003:Cyprus 1998:Aegean 1956:Bengal 1949:Hybrid 1930:Toyger 1910:Sphynx 1905:Somali 1830:Ocicat 1760:Foldex 1730:Cymric 1690:Bombay 1685:Birman 1627:Breeds 1503:Lolcat 1411:Senses 1362:Catnip 1327:senior 1299:Health 1247:Kitten 1137:Portal 1113:Virome 876:Capsid 754:  717:  707:  674:  664:  631:  589:  582:104413 579:  546:  517:  482:  472:  458:: 27. 85:  78:  71:  64:  56:  2353:53182 2335:IRMNG 2314:3DXSS 2186:Japan 1800:Lykoi 1790:Korat 1646:Fully 1307:Aging 1029:Other 834:Virus 710:85393 156:Realm 149:Virus 90:JSTOR 76:books 2348:NCBI 2148:Tick 2063:Flea 2038:Acne 1915:Thai 1810:Manx 1384:Purr 1379:Meow 1317:Diet 789:2019 752:PMID 715:PMID 672:PMID 629:PMID 587:PMID 544:PMID 515:PMID 480:PMID 62:news 2322:EoL 2309:CoL 2018:Van 744:doi 732:271 705:PMC 697:doi 662:PMC 654:doi 621:doi 617:220 577:PMC 569:doi 536:doi 532:123 505:doi 470:PMC 460:doi 278:or 45:by 2372:: 2350:: 2337:: 2324:: 2311:: 2296:: 2281:: 832:: 780:. 750:. 742:. 730:. 713:. 703:. 693:37 691:. 687:. 670:. 660:. 648:. 644:. 627:. 615:. 601:. 585:. 575:. 565:73 563:. 559:. 542:. 530:. 513:. 501:17 499:. 495:. 478:. 468:. 454:. 450:. 158:: 1639:) 1635:( 1633:) 1629:( 1208:e 1201:t 1194:v 822:e 815:t 808:v 791:. 778:" 758:. 746:: 738:: 721:. 699:: 678:. 656:: 650:2 635:. 623:: 605:. 593:. 571:: 550:. 538:: 521:. 507:: 486:. 462:: 456:4 112:) 106:( 101:) 97:( 87:· 80:· 73:· 66:· 39:.

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"Feline foamy virus"
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Virus classification
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Virus
Riboviria
Pararnavirae
Artverviricota
Revtraviricetes
Ortervirales
Retroviridae
Felispumavirus
Synonyms
retrovirus
Retroviridae
Spumaretrovirinae
Felispumavirus
Puma feline foamy virus
Spumaviruses
Retroviruses
reverse transcription

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