Knowledge (XXG)

Flavivirus

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and several crustaceans and cephalopods. These sequences appear to be related to those in the insect-specific flaviviruses and also the Tamana bat virus groupings. While it is not presently clear how aquatic flaviviruses fit into the evolution of this group of viruses, there is some evidence that one
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domain. It uses the helicase ATP hydrolysis site to remove the γ-phosphate from the 5′ end of the RNA. The N-terminal domain of the non-structural protein 5 (NS5) has both the N7-methyltransferase and guanylyltransferase activities necessary for forming mature RNA cap structures. RNA binding affinity
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The term "yellow fever" appears on p. 186. On p. 188, Mitchell mentions "... the distemper was what is generally called the yellow fever in America." However, on pages 191–192, he states "... I shall consider the cause of the yellowness which is so remarkable in this distemper, as to have given it
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in a concentration dependent manner. Accumulation of sfRNA causes (1) antagonization of the cell's innate immune response, thus decreasing host defense against the virus (2) inhibition of XRN1 and Dicer activity to modify RNAi pathways that destroy viral RNA (3) modification of the viral replication
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and are found adjacent to each other within the 3'UTR. They appear to be widely conserved across the Flaviviradae. These DB elements have a secondary structure consisting of three helices and they play a role in ensuring efficient translation. Deletion of DB1 has a small but significant reduction in
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An alternate approach to the development of flavivirus vaccine vectors is based on the use of viruses that infect insects. Insect-specific flaviviruses, such as Binjari virus, are unable to replicate in vertebrate cells. Nevertheless, recombinant viruses in which structural protein genes (prME) of
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appears to have evolved within the last 1000 years. The viral genomes can be divided into 2 clades — A and B. Clade A has five genotypes, and clade B has one. These clades separated about 700 years ago. This separation appears to have occurred in the Kurgan province. Clade A subsequently underwent
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Evolutionary relationships between endogenised viral elements of Flaviviruses and contemporary flaviviruses using maximum likelihood approaches have identified that arthropod-vectored flaviviruses likely emerged from an arachnid source. This contradicts earlier work with a smaller number of extant
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5'UTR, a large stem loop (SLA) and a short stem loop (SLB). SLA folds into a Y-shaped structure with a side stem loop and a small top loop. SLA is likely to act as a promoter, and is essential for viral RNA synthesis. SLB is involved in interactions between the 5'UTR and 3'UTR which result in the
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Estimates of divergence times have been made for several of these viruses. The origin of these viruses appears to be at least 9400 to 14,000 years ago. The Old World and New World dengue strains diverged between 150 and 450 years ago. The European and Far Eastern tick-borne encephalitis strains
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as well as arthropods, insect-specific flaviviruses are restricted to their competent arthropods. The means by which flaviviruses establish persistent infection in their competent vectors and cause disease in humans depends upon several virus-host interactions, including the intricate interplay
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Currently 8 secondary structures have been identified within the 3'UTR of WNV and are (in the order in which they are found with the 3'UTR) SL-I, SL-II, SL-III, SL-IV, DB1, DB2 and CRE. Some of these secondary structures have been characterised and are important in facilitating
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has shown that it emerged as a distinct virus around 1000 years ago. This initial virus developed into two distinct lineages, lineage 1 and its multiple profiles is the source of the epidemic transmission in Africa and throughout the world. Lineage 2 was considered an Africa
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approximately 277 (475–137) years ago. This time corresponds to the settlement of Australia from Europe. The Japanese encephalitis group appears to have evolved in Africa 2000–3000 years ago and then spread initially to South East Asia before migrating to the rest of Asia.
2905:. ... These new vaccine platforms generated from insect-specific flaviviruses and alphaviruses represent affordable, efficient, and safe approaches to rapid development of infectious, attenuated vaccines against pathogens from these two virus families. 2884:
are in varying stages of development. CYD-TDV, sold under the trade name Dengvaxia, is a tetravalent chimeric vaccine that splices structural genes of the four dengue viruses onto a 17D yellow fever backbone. Dengvaxia is approved in five countries.
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CRE is the Cis-acting replication element, also known as the 3'SL RNA elements, and is thought to be essential in viral replication by facilitating the formation of a "replication complex". Although evidence has been presented for an existence of a
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The flaviviruses can be divided into two clades: one with vector-borne viruses and the other with no known vector. The vector clade, in turn, can be subdivided into a mosquito-borne clade and a tick-borne clade. These groups can be divided again.
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Chang RY, Hsu TW, Chen YL, Liu SF, Tsai YJ, Lin YT, Chen YS, Fan YH (27 September 2013). "Japanese encephalitis virus non-coding RNA inhibits activation of interferon by blocking nuclear translocation of interferon regulatory factor 3".
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Binjari virus are exchanged with those of dengue virus, Zika virus, West Nile virus, yellow fever virus, or Japanese encephalitis virus replicate efficiently in insect cells where high titers of infectious virus particles are produced.
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milk products. Transmission from nonhuman vertebrates to humans without an intermediate vector arthropod however mostly occurs with low probability. For example, early tests with yellow fever showed that the disease is not
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to safer and more effective second generation Japanese encephalitis vaccines. These may come into wide use to effectively prevent this severe disease in the huge populations of Asia—North, South and Southeast.
3242:"Account of the Yellow fever which prevailed in Virginia in the years 1737, 1741, and 1742, in a letter to the late Cadwallader Colden, Esq. of New York, from the late John Mitchell, M.D.F.R.S. of Virginia" 1085:
diverged about 1087 (1610–649) years ago. European tick-borne encephalitis and louping ill viruses diverged about 572 (844–328) years ago. This latter estimate is consistent with historical records.
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products. Nevertheless, cellular post-translational modification is dependent on the presence of a poly-A tail; therefore this process is not host-dependent. Instead, the poly-protein contains an
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The mosquito group can be divided into two branches: one branch contains neurotropic viruses, often associated with encephalitic disease in humans or livestock. This branch tends to be spread by
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McLean BJ, Hobson-Peters J, Webb CE, Watterson D, Prow NA, Nguyen HD, Hall-Mendelin S, Warrilow D, Johansen CA, Jansen CC, van den Hurk AF, Beebe NW, Schnettler E, Barnard RT, Hall RA (2015).
5681: 873:(JEV) genome. The JEV hairpin is significantly over-represented upon host cell infection and it has been suggested that the hairpin structure may play a role in regulating RNA synthesis. 3005:
Postler TS, Beer M, Blitvich BJ, Bukh J, de Lamballerie X, Drexler JF, Imrie A, Kapoor A, Karganova GG, Lemey P, Lohmann V, Simmonds P, Smith DB, Stapleton JT, Kuhn JH (10 August 2023).
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structure in this RNA, it does not appear to be well conserved across flaviviruses. Deletions of the 3' UTR of flaviviruses have been shown to be lethal for infectious clones.
5226:"Discovery of Novel Crustacean and Cephalopod Flaviviruses: Insights into the Evolution and Circulation of Flaviviruses between Marine Invertebrate and Vertebrate Hosts" 4647:"Discovery of Novel Crustacean and Cephalopod Flaviviruses: Insights into the Evolution and Circulation of Flaviviruses between Marine Invertebrate and Vertebrate Hosts" 4880:
From statements by Orsolya Kutasi, DVM, of the Szent Istvan University, Hungary at the 2009 American Association of Equine Practitioners Convention, December 5–9, 2009.
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Shi PY, Brinton MA, Veal JM, Zhong YY, Wilson WD (April 1996). "Evidence for the existence of a pseudoknot structure at the 3' terminus of the flavivirus genomic RNA".
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The dengue viruses produce many millions of infections annually due to transmission by a successful global mosquito vector. As mosquito control has failed, several
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Karan LS, Ciccozzi M, Yakimenko VV, Presti AL, Cella E, Zehender G, Rezza G, Platonov AE (2014). "The deduced evolution history of Omsk hemorrhagic fever virus".
3085:"A novel insect-specific flavivirus replicates only in Aedes-derived cells and persists at high prevalence in wild Aedes vigilax populations in Sydney, Australia" 9589: 853:
digestion. Nuclease resistance protects the downstream 3' UTR RNA fragment from degradation and is essential for virus-induced cytopathicity and pathogenicity.
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the name of the Yellow Fever." Mitchell misdiagnosed the disease that he observed and treated, and the disease was probably Weil's disease or hepatitis. See:
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complex to increase viral reproduction. Overall, sfRNA is implied in multiple pathways that compromise host defenses and promote infection by flaviviruses.
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is crucial to the replication of the flavivirus, as it translates the RNA, in a similar fashion to cellular mRNA, resulting in the synthesis of a single
535:(NS1, NS2A, NS2B, NS3, NS4A, NS4B, NS5). The genomic RNA is modified at the 5′ end of positive-strand genomic RNA with a cap-1 structure (me-GpppA-me). 1152:
division into clade C, D and E 230 years ago. Clade C and E appear to have originated in the Novosibirsk and Omsk Provinces, respectively. The muskrat
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which are non-segmented and around 10–11 kbp in length. In general, the genome encodes three structural proteins (Capsid, prM, and Envelope) and seven
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species and to have bird reservoirs. The second branch is the non-neurotropic viruses associated with human haemorrhagic disease. These tend to have
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The viruses that lack a known vector can be divided into three groups: one closely related to the mosquito-borne viruses, which is associated with
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Other virus transmission routes for arboviruses include handling infected animal carcasses, blood transfusion, sex, childbirth and consumption of
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Clarke BD, Roby JA, Slonchak A, Khromykh AA (3 August 2015). "Functional non-coding RNAs derived from the flavivirus 3′ untranslated region".
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vaccines were introduced in the middle of the 20th century. Unacceptable adverse events have prompted change from a mouse-brain inactivated
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upstream of the DB elements. The function of this conserved structure is unknown but is thought to contribute to ribonuclease resistance.
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These two conserved secondary structures are also known as pseudo-repeat elements. They were originally identified within the genome of
3965:"Identification of Specific Nucleotide Sequences within the Conserved 3′-SL in the Dengue Type 2 Virus Genome Required for Replication" 680:
A G protein-coupled receptor kinase 2 (also known as ADRBK1) appears to be important in entry and replication for several viruses in
4299:"A noncoding RNA produced by arthropod-borne flaviviruses inhibits the cellular exoribonuclease XRN1 and alters host mRNA stability" 121: 5607: 2892:
Immunization of mice with a Binjari vaccine bearing the Zika virus structural proteins protected mice from disease after challenge
2255: 1286: 569:. This feature allows the virus to exploit cellular apparatuses to synthesize both structural and non-structural proteins, during 9635: 9602: 2140: 1728: 1384: 156: 5625: 4763:
Moureau G, Cook S, Lemey P, Nougairede A, Forrester NL, Khasnatinov M, Charrel RN, Firth AE, Gould EA, De Lamballerie X (2015).
3327: 5103:"A 1958 Isolate of Kedougou Virus (KEDV) from Ndumu, South Africa, Expands the Geographic and Temporal Range of KEDV in Africa" 3636:
Brinton MA, Dispoto JH (1988). "Sequence and secondary structure analysis of the 5'-terminal region of flavivirus genome RNA".
4481:"Comparative analysis of genome-encoded viral sequences reveals the evolutionary history of flavivirids (family Flaviviridae)" 1440: 445:. Human infections with most of these arboviruses are incidental, as humans are unable to replicate the virus to high enough 59: 3007:"Renaming of the genus Flavivirus to Orthoflavivirus and extension of binomial species names within the family Flaviviridae" 2598: 1377: 515:
and spherical and have icosahedral geometries with a pseudo T=3 symmetry. The virus particle diameter is around 50 nm.
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and 2′-O methyltransferase. The virus encodes these activities in its non-structural proteins. The NS3 protein encodes a
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Bidet K, Garcia-Blanco MA (1 September 2014). "Flaviviral RNAs: weapons and targets in the war between virus and host".
3722:"Specific requirements for elements of the 5' and 3' terminal regions in flavivirus RNA synthesis and viral replication" 1754: 1575:
with vectors; tick-borne (black), mosquito-borne (purple), with no known vector (red), invertebrate viruses (blue/green)
1398: 652: 74: 7467: 2132: 1679: 1293: 869: 666: 549: 532: 55: 2781: 2760: 1943: 1936: 4440:"Phylogenetic relationships of flaviviruses correlate with their epidemiology, disease association and biogeography" 3916:"Accumulation of a 3′-Terminal Genome Fragment in Japanese Encephalitis Virus-Infected Mammalian and Mosquito Cells" 2795: 206: 9211: 8716: 7790: 3226: 2788: 2673: 1623: 9594: 2239: 1050:; a second, genetically more distant, is also associated with bats; and a third group is associated with rodents. 81: 48: 980:
replication and pathogenesis. sfRNA is produced by incomplete degradation of genomic viral RNA by the host cells
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family reproduce in either arthropods or vertebrates, but not both, with one odd member of the genus affecting a
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membranes in membranous compartments. New viral particles are subsequently assembled. This occurs during the
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feature which automatically releases the first peptide, a virus specific enzyme. This enzyme is then able to
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Funk A, Truong K, Nagasaki T, Torres S, Floden N, Melian EB, Edmonds J, Dong H, Shi PY (1 November 2010).
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Several partial and complete genomes of flaviviruses have been found in aquatic invertebrates such as the
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van den Hurk AF, Suen WW, Hall RA, O'Brien CA, Bielefeldt-Ohmann H, Hobson-Peters J, Colmant AM (2016).
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between flavivirus-encoded immune antagonists and the host antiviral innate immune effector molecules.
70: 8452: 3358:"Nucleotide sequence of yellow fever virus: implications for flavivirus gene expression and evolution" 2809: 2480: 2456: 2271: 2202: 2101: 2051: 2022: 1906: 1885: 1871: 1841: 1223: 9607: 9550: 9029: 8551: 7746: 6025: 5694: 5475: 4892:"Fatal neurologic disease and abortion in mare infected with lineage 1 West Nile virus, South Africa" 4776: 4707: 4596: 4152: 3485: 3426: 3369: 2961: 2858: 2614: 2590: 2553: 2435: 2367: 2210: 1994: 1952: 1639: 1447: 1419: 1258: 1244: 810: 785: 201: 8848: 8516: 8459: 8431: 8403: 8073: 7757: 7688: 6948: 6941: 6032: 5990: 5983: 2738: 2709: 2659: 2464: 2406: 2302: 2294: 2194: 2109: 2067: 1987: 1980: 1922: 1878: 1864: 1820: 1496: 1489: 1335: 1328: 9043: 8897: 8676: 8424: 8417: 7237: 6435: 6053: 6039: 5997: 5910: 2753: 2687: 2537: 2499: 2359: 2309: 2263: 2181: 2001: 1705: 1663: 1524: 1475: 1307: 1272: 1209: 828: 773: 589: 431: 9135: 9086: 9036: 9015: 8466: 5976: 2652: 2638: 2390: 2351: 2247: 2223: 2124: 2059: 1804: 1433: 1363: 1279: 1195: 952:
and is thought to direct translation of capsid proteins. It is located just downstream of the AUG
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Moon SL, Anderson JR, Kumagai Y, Wilusz CJ, Akira S, Khromykh AA, Wilusz J (1 November 2012).
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Le Sommer C, Barrows NJ, Bradrick SS, Pearson JL, Garcia-Blanco MA (2012). Michael SF (ed.).
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SL-II has been suggested to contribute to nuclease resistance. It may be related to another
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The 3'UTRs are typically 0.3–0.5 kb in length and contain a number of highly conserved
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to reinfect the arthropods needed to continue the virus life-cycle – humans are then a
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and the other – the tick-borne encephalitis complex viruses – is associated primarily with
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Humans, mammals, mosquitoes, and ticks serve as the natural host. Transmission routes are
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the remaining poly-protein into the individual products. One of the products cleaved is a
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Chapman EG, Costantino DA, Rabe JL, Moon SL, Wilusz J, Nix JC, Kieft JS (18 April 2014).
1158:, which is highly susceptible to this virus, was introduced into this area in the 1930s. 376:, as well as insect-specific flaviviruses (ISFs) such as cell fusing agent virus (CFAV), 5479: 4780: 4711: 4600: 4156: 3489: 3430: 3373: 2965: 95: 9444: 9422: 9390: 9355: 9261: 9226: 9162: 9005: 8994: 8957: 8799: 8683: 8573: 8502: 8492: 8253: 8045: 8008: 7914: 7709: 7293: 7266: 6913: 6902: 6806: 6771: 6764: 6750: 6743: 6692: 6664: 6594: 6583: 6548: 6332: 6135: 6004: 5941: 5875: 5853: 5775: 5579: 5554: 5331: 5299: 5274: 5250: 5225: 5129: 5102: 4965: 4940: 4916: 4891: 4799: 4764: 4671: 4646: 4619: 4584: 4505: 4480: 4331: 4298: 4238: 4205: 4181: 4140: 4073: 4048: 3847: 3822: 3795: 3770: 3746: 3721: 3697: 3672: 3613: 3586: 3559: 3532: 3508: 3473: 3449: 3414: 3203: 3176: 3152: 3125: 3124:
Elrefaey AM, Abdelnabi R, Rosales Rosas AL, Wang L, Basu S, Delang L (September 2020).
2982: 2949: 2881: 2088: 1762: 1567: 1412: 1321: 815: 512: 473: 423: 184: 5445: 5416: 4415: 4390: 3989: 3964: 3940: 3915: 3823:"Control of Translation by the 5′- and 3′-Terminal Regions of the Dengue Virus Genome" 2845: 1587: 1076: 976:
RNA (sfRNA) is an extension of the 3' UTR and has been demonstrated to play a role in
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translation but deletion of DB2 has little effect. Deleting both DB1 and DB2 reduced
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Venter M, Human S, van Niekerk S, Williams J, van Eeden C, Freeman F (August 2011).
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Filomatori CV, Lodeiro MF, Alvarez DE, Samsa MM, Pietrasanta L, Gamarnik AV (2006).
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Gaunt MW, Sall AA, de Lamballerie X, Falconar AK, Dzhivanian TI, Gould EA (2001).
3177:"Innate Immune Antagonism of Mosquito-Borne Flaviviruses in Humans and Mosquitoes" 407:
Flaviviruses share several common aspects: common size (40–65 nm), symmetry (
173: 4789: 4609: 4275: 4141:"The Structural Basis of Pathogenic Subgenomic Flavivirus RNA (sfRNA) Production" 3549: 3533:"G protein-coupled receptor kinase 2 promotes flaviviridae entry and replication" 3498: 3439: 3175:
Elrefaey AM, Hollinghurst P, Reitmayer CM, Alphey L, Maringer K (November 2021).
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Sirohi D, Chen Z, Sun L, Klose T, Pierson TC, Rossmann MG, Kuhn RJ (April 2016).
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viruses showing that the tick-borne viruses emerged from a mosquito-borne group.
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had been detected in horses and humans in South Africa. A 2007 fatal case in a
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process which is also responsible for the accumulation of the envelope and cell
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Epithelium: skin; epithelium: kidney; epithelium: intestine; epithelium: testes
147: 9172: 9128: 9022: 8783: 7592: 7582: 7334: 6934: 6261: 6011: 5610:– Dengue Fever research at the Novartis Institute for Tropical Diseases (NITD) 4719: 4560: 4543: 2895: 2330: 1545: 1134: 1058: 930: 465: 385: 365: 159: 5290: 4358:. Special Issue: Functions of the ends of positive strand RNA virus genomes. 4322: 4229: 4172: 4117: 3032: 1035:
The tick-borne viruses also form two distinct groups: one is associated with
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Most of these viruses are primarily transmitted by the bite from an infected
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Flint J, Racaniello VR, Rall GF, Hatziiannou T, Skalka AM (3 August 2020).
5349: 5308: 5259: 5193: 5138: 5009: 4974: 4956: 4925: 4907: 4849: 4840: 4823: 4808: 4727: 4695: 4680: 4628: 4569: 4514: 4465: 4375: 4340: 4314: 4283: 4247: 4190: 4125: 4082: 3949: 3900: 3856: 3804: 3755: 3706: 3673:"A 5' RNA element promotes dengue virus RNA synthesis on a circular genome" 3622: 3568: 3517: 3458: 3308: 3299: 3282: 3212: 3161: 3110: 3040: 2991: 5507: 5488: 5454: 4424: 4033: 3998: 3657: 3474:"Comprehensive Annotation of Mature Peptides and Genotypes for Zika Virus" 3389: 3225:
The earliest mention of "yellow fever" appears in a manuscript of 1744 by
9507: 5241: 5184: 5167: 5073: 5057: 4662: 4496: 4221: 3356:
Rice C, Lenches E, Eddy S, Shin S, Sheets R, Strauss J (23 August 1985).
3281:
Bekal S, Domier LL, Gonfa B, McCoppin NK, Lambert KN, Bhalerao K (2014).
2861:, introduced in 1937, produced dramatic reductions in epidemic activity. 1142: 1106: 688: 636: 601: 574: 489: 401: 5570: 3769:
Alvarez DE, Lodeiro MF, Ludueña SJ, Pietrasanta LI, Gamarnik AV (2005).
3688: 801:
cyclisation of the viral RNA, which is essential for viral replication.
400:, and yellow fever in turn is named from its propensity to cause yellow 9568: 5464:"Population dynamics of flaviviruses revealed by molecular phylogenies" 4109: 3472:
Sun G, Larsen C, Baumgarth N, Klem E, Scheuermann R (26 January 2017).
3413:
Henderson BR, Saeedi BJ, Campagnola G, Geiss BJ (2011). Jeang K (ed.).
3237:
of Philadelphia; the manuscript was eventually reprinted in 1814. See:
1788: 1065:
of these viruses, Wenzhou shark flavivirus, infects both a crustacean (
1036: 1029: 670: 5655:
Rfam entry for the Japanese encephalitis virus (JEV) hairpin structure
5415:
Kuno G, Chang GJ, Tsuchiya KR, Karabatsos N, Cropp CB (January 1998).
5119: 5001: 4025: 3193: 3142: 883:
This secondary structure is located within the 3'UTR of the genome of
565:
molecule in all aspects except for the absence of the poly-adenylated
5650:
Rfam entry for Flavivirus 3' UTR cis-acting replication element (CRE)
4206:"RNA Structures Required for Production of Subgenomic Flavivirus RNA" 3771:"Long-range RNA-RNA interactions circularize the dengue virus genome" 3603: 1615: 1040: 949: 528: 9484: 3415:"Analysis of RNA binding by the Dengue virus NS5 RNA capping enzyme" 4694:
Shi M, Lin XD, Chen X, Tian JH, Chen LJ, Li K, et al. (2018).
968:
Different fates of viral RNA of flaviviruses and formation of sfRNA
897: 5635:
Virus Pathogen Database and Analysis Resource (ViPR): Flaviviridae
2844: 1586: 1566: 1130: 1118: 1075: 1024: 1018: 996: 963: 896: 814: 756: 674: 619: 542: 499: 446: 397: 369: 218: 5654: 5649: 5644: 5639: 4939:
St Leger J, Wu G, Anderson M, Dalton L, Nilson E, Wang D (2011).
3873:
Pijlman GP, Funk A, Kondratieva N, et al. (December 2008).
1114: 635:, the polyprotein is cleaved by a combination of viral and host 562: 9488: 9352: 9223: 8713: 7787: 7464: 6864: 5715: 5663: 5031: 4941:"West Nile virus infection in a killer whale, Texas, USA, 2007" 4585:"Identification of a flavivirus sequence in a marine arthropod" 2922: 9555: 5326:. Advances in Virus Research. Vol. 88. pp. 315–372. 5275:"Latest developments and future directions in dengue vaccines" 4389:
Kuno G, Chang GJ, Tsuchiya KR, Karabatsos N, Cropp CB (1998).
1047: 427: 31: 5101:
Jansen van Vuren P, Parry R, Khromykh AA, Paweska JT (2021).
835:
family. The majority of analysis has been carried out using
584:
Cellular RNA cap structures are formed via the action of an
392:
Flaviviruses are named for the yellow fever virus; the word
5462:
Zanotto PM, Gould EA, Gao GF, Harvey PH, Holmes EC (1996).
5056:
Robin Y, Cornet M, Le Gonidec G, Chateau R, Heme G (1978).
2950:"The 3.8 Å resolution cryo-EM structure of Zika virus" 5388:
Principles of Virology, Volume 2: Pathogenesis and Control
1073:) shark host, indicating an aquatic arbovirus life cycle. 624:
Replication complex formed on the cytoplasmic side of the
3260:(1957) "John Mitchell, Benjamin Rush, and Yellow fever". 960:
The role of RNA secondary structures in sfRNA production
5032:"International Committee on Taxonomy of Viruses (ICTV)" 3229:
of Virginia; copies of the manuscript were sent to Mr.
4824:"Alexander the Great and West Nile virus encephalitis" 4479:
Bamford CGG, de Souza WM, Parry R, Gifford RJ (2022).
617:. This protein also encodes a 2′-O methyltransferase. 430:
around 10,000–11,000 bases), and appearance under the
4865:"Different West Nile Virus Genetic Lineage Evolving?" 2927:
International Committee on Taxonomy of Viruses (ICTV)
796:. There are two conserved structural elements in the 764:
RNA genome showing the 3' and 5' UTRs and cyclisation
5391:(5th ed.). John Wiley & Sons. p. 327. 4696:"The evolutionary history of vertebrate RNA viruses" 3720:
Yu L, Nomaguchi M, Padmanabhan R, Markoff L (2008).
3587:"Functional RNA elements in the dengue virus genome" 9497: 9432: 9410: 9399: 9388: 9377: 9366: 9281: 9270: 9259: 9248: 9237: 9210: 9160: 9149: 9053: 9003: 8992: 8966: 8955: 8922: 8911: 8808: 8797: 8771: 8760: 8749: 8738: 8727: 8664: 8634: 8612: 8601: 8561: 8490: 8377: 8366: 8355: 8325: 8314: 8288: 8277: 8251: 8240: 8207: 8164: 8153: 8142: 8098: 8087: 8054: 8043: 8017: 8006: 7952: 7888: 7845: 7834: 7823: 7812: 7801: 7727: 7669: 7658: 7647: 7617: 7606: 7580: 7569: 7522: 7511: 7500: 7489: 7478: 7451: 7403: 7365: 7354: 7343: 7332: 7291: 7280: 7254: 7225: 7203: 7181: 7159: 7148: 7137: 7107: 7096: 7070: 7059: 7048: 7037: 7003: 6992: 6981: 6970: 6922: 6911: 6900: 6889: 6878: 6731: 6709: 6673: 6662: 6655: 6603: 6592: 6581: 6570: 6536: 6514: 6492: 6470: 6459: 6433: 6422: 6396: 6385: 6374: 6330: 6308: 6286: 6275: 6249: 6227: 6216: 6205: 6194: 6183: 6145: 6123: 6112: 6101: 6090: 6079: 5950: 5939: 5928: 5884: 5873: 5862: 5851: 5840: 5802: 5773: 5762: 5751: 5740: 5729: 5702: 3351: 3349: 1559:
List of species and strains of flavivirus by vector
62:. Unsourced material may be challenged and removed. 5616:– Depository of dengue virus genomic sequence data 561:of the host cells. The genome mimics the cellular 3283:"A novel flavivirus in the soybean cyst nematode" 2894:. A similar approach employs the insect-specific 3408: 3406: 3240:Mitchell, John (written: 1744; reprinted: 1814) 441:(mosquito or tick), and hence are classified as 384:(PaRV). While dual-host flaviviruses can infect 5608:Novartis Institute for Tropical Diseases (NITD) 5468:Proceedings of the National Academy of Sciences 4640: 4638: 3963:Zeng L, Falgout B, Markoff L (September 1998). 3868: 3866: 3816: 3814: 3585:Gebhard LG, Filomatori CV, Gamarnik AV (2011). 3580: 3578: 2887: 5536:Molecular Virology and Control of Flaviviruses 5364:"WHO Questions and Answers on Dengue Vaccines" 3056:Molecular Virology and Control of Flaviviruses 819:RNA secondary structure elements of different 5675: 8: 5640:Rfam entry for Flavivirus 3'UTR stem loop IV 5219: 5217: 5215: 5213: 5211: 5151:: CS1 maint: multiple names: authors list ( 5086:: CS1 maint: multiple names: authors list ( 4822:Galli M, Bernini F, Zehender G (July 2004). 4748:: CS1 maint: multiple names: authors list ( 4527:: CS1 maint: multiple names: authors list ( 3322: 3320: 3318: 3276: 3274: 2256:Israel turkey meningoencephalomyelitis virus 1287:Israel turkey meningoencephalomyelitis virus 3821:Chiu WW, Kinney RM, Dreher TW (July 2005). 3246:American Medical and Philosophical Register 9485: 9407: 9396: 9385: 9374: 9363: 9349: 9278: 9267: 9256: 9245: 9234: 9220: 9216: 9157: 9000: 8963: 8919: 8805: 8768: 8757: 8746: 8735: 8724: 8710: 8609: 8374: 8363: 8322: 8285: 8248: 8161: 8150: 8095: 8051: 8014: 7842: 7831: 7820: 7809: 7798: 7784: 7666: 7655: 7614: 7577: 7519: 7508: 7497: 7486: 7475: 7461: 7457: 7362: 7351: 7340: 7288: 7156: 7145: 7104: 7067: 7056: 7045: 7000: 6989: 6978: 6919: 6908: 6897: 6886: 6875: 6861: 6670: 6659: 6600: 6589: 6578: 6467: 6430: 6393: 6382: 6283: 6224: 6213: 6202: 6191: 6120: 6109: 6098: 6087: 5947: 5936: 5881: 5870: 5859: 5848: 5770: 5759: 5748: 5737: 5726: 5712: 5708: 5682: 5668: 5660: 1686:Tick-borne encephalitis virus serocomplex 1113:was detected in South Africa in 2010 in a 831:which are conserved and restricted to the 790:The 5'UTRs are 95–101 nucleotides long in 693: 172: 146: 135: 5578: 5497: 5487: 5444: 5298: 5249: 5183: 5128: 5118: 4964: 4915: 4839: 4798: 4788: 4670: 4618: 4608: 4559: 4504: 4455: 4414: 4330: 4237: 4180: 4072: 3988: 3939: 3890: 3846: 3794: 3745: 3696: 3612: 3602: 3558: 3548: 3507: 3497: 3448: 3438: 3298: 3202: 3192: 3151: 3141: 3100: 3022: 2981: 122:Learn how and when to remove this message 5538:. Norfolk, UK: Caister Academic Press. 3914:Lin KC, Chang HL, Chang RY (May 2004). 2914: 1579:Species and strains sorted by vectors: 918:efficiency of the viral genome to 25%. 841:(WNV) to study the function the 3'UTR. 5144: 5079: 4741: 4520: 2849:Time-line of historical highlights of 2599:Montana myotis leukoencephalitis virus 2474:Viruses with no known arthropod vector 1378:Montana myotis leukoencephalitis virus 5553:Murray CL, Jones CT, Rice CM (2008). 2725:Mediterranean Ochlerotatus flavivirus 1672:Spanish sheep encephalomyelitis virus 1008:with corresponding vectors and groups 945:structure was later found in several 7: 5645:Rfam entry for Flavivirus DB element 60:adding citations to reliable sources 5517:Molecular Biology of the Flavivirus 4391:"Phylogeny of the genus Flavivirus" 3262:Bulletin of the History of Medicine 5332:10.1016/B978-0-12-800098-4.00007-6 5224:Parry R, Asgari S (15 July 2019). 4834:(7): 1330–2, author reply 1332–3. 3233:, a physician in New York, and to 2803:Viruses known only from sequencing 2097:Japanese encephalitis virus group 1080:Distribution of major flaviviruses 728:Humans; mammals; mosquitoes; ticks 665:genomic RNA replication occurs on 25: 5519:. Wymondham: Horizon Bioscience. 4863:West, Christy (8 February 2010). 849:and protecting the 3'UTR from 5' 768:The positive sense RNA genome of 484:The known non-arboviruses of the 453:. The exceptions to this are the 5324:Dengue Virus Vaccine Development 5279:Therapeutic Advances in Vaccines 3932:10.1128/JVI.78.10.5133-5138.2004 3839:10.1128/JVI.79.13.8303-8315.2005 3787:10.1128/JVI.79.11.6631-6643.2005 2141:Murray Valley encephalitis virus 1729:Alkhurma hemorrhagic fever virus 1680:Turkish sheep encephalitis virus 1385:Murray Valley encephalitis virus 753:RNA secondary structure elements 205: 36: 5603:MicrobiologyBytes: Flaviviruses 4065:10.1128/JVI.80.5.2170-2182.2006 3981:10.1128/JVI.72.9.7510-7522.1998 2923:"Virus Taxonomy: 2018b Release" 2782:Southern Pygmy squid flavivirus 2761:Ochlerotatus caspius flavivirus 1944:Spanish Ochlerotatus flavivirus 1937:Ochlerotatus caspius flavivirus 867:identified in the 5'UTR of the 47:needs additional citations for 4368:10.1016/j.virusres.2015.01.026 2796:Xishuangbanna Aedes flavivirus 1834:Without known vertebrate host 1441:Saint Louis encephalitis virus 1175:there are 53 defined species: 605:is reduced by the presence of 557:Flaviviruses replicate in the 1: 2874:Japanese encephalitis vaccine 2789:Soybean cyst nematode virus 5 2674:Gammarus chevreuxi flavivirus 1779:Tick-borne encephalitis virus 1721:Kyasanur Forest disease virus 1624:Greek goat encephalitis virus 1597:Kyasanur forest disease virus 1593:tick-borne encephalitis virus 1483:Tick-borne encephalitis virus 1343:Kyasanur Forest disease virus 1149:Omsk haemorrhagic fever virus 1121:; previously, only lineage 2 734:Clathrin-mediated endocytosis 358:tick-borne encephalitis virus 318: 4790:10.1371/journal.pone.0117849 4610:10.1371/journal.pone.0146037 4276:10.1016/j.vetmic.2013.04.026 3650:10.1016/0042-6822(88)90468-0 3550:10.1371/journal.pntd.0001820 3499:10.1371/journal.pone.0170462 3440:10.1371/journal.pone.0025795 2240:Duck egg drop syndrome virus 2158:St. Louis encephalitis virus 1755:Omsk hemorrhagic fever virus 1601:Omsk hemorrhagic fever virus 1399:Omsk hemorrhagic fever virus 653:RNA-dependent RNA polymerase 5559:Nature Reviews Microbiology 5437:10.1128/JVI.72.1.73-83.1998 5172:Journal of General Virology 4990:Journal of Medical Virology 4457:10.1099/0022-1317-82-8-1867 4407:10.1128/JVI.72.1.73-83.1998 3738:10.1016/j.virol.2007.12.035 3287:Journal of General Virology 3102:10.1016/j.virol.2015.07.021 2133:Japanese encephalitis virus 1294:Japanese encephalitis virus 1069:) Pacific spadenose shark ( 901:Secondary structure of the 870:Japanese encephalitis virus 667:rough endoplasmic reticulum 550:Japanese encephalitis virus 340:positive-strand RNA viruses 9662: 4645:Parry R, Asgari S (2019). 4542:Cook S, Holmes EC (2006). 4047:Clyde K, Harris E (2006). 3892:10.1016/j.chom.2008.10.007 3024:10.1007/s00705-023-05835-1 2646:Crangon crangon flavivirus 808: 783: 187:model, colored by chains, 9362: 9348: 9233: 9219: 8723: 8709: 7797: 7783: 7474: 7460: 6874: 6860: 5725: 5711: 4720:10.1038/s41586-018-0012-7 4561:10.1007/s00705-005-0626-6 2831:Culex theileri flavivirus 2817:Aedes cinereus flavivirus 2681:Gammarus pulex flavivirus 2339:Yellow fever virus group 1893:Culex theileri flavivirus 1858:Aedes galloisi flavivirus 746:Zoonosis; arthropod bite 348:. The genus includes the 316: 311: 200: 180: 171: 154: 145: 138: 5417:"Phylogeny of the genus 5291:10.1177/2051013613507862 3330:. ExPASy. Archived from 2859:yellow fever 17D vaccine 2667:Firefly squid flavivirus 1900:Spanish Culex flavivirus 1067:Portunus trituberculatus 9636:Rodent-carried diseases 4264:Veterinary Microbiology 4165:10.1126/science.1250897 3382:10.1126/science.4023707 2974:10.1126/science.aaf5316 2870:Tick-borne encephalitis 2824:Aedes vexans flavivirus 2030:Yunnan Culex flavivirus 1849:Cell fusing agent virus 1791:tick-borne virus group 1618:tick-borne virus group 1071:Scoliodon macrorhynchos 1028:species as vectors and 982:5'-3' exoribonuclease 1 943:conserved hairpin (cHP) 533:non-structural proteins 338:in 2023, is a genus of 4957:10.3201/eid1708.101979 4908:10.3201/eid1708.101794 4841:10.3201/eid1007.040396 4315:10.1261/rna.034330.112 3300:10.1099/vir.0.060889-0 3060:Caister Academic Press 3054:Shi, P-Y, ed. (2012). 2907: 2864:Effective inactivated 2854: 2775:Parramatta River virus 2718:Marisma mosquito virus 2625:Non vertebrate viruses 2570:Rio Bravo virus group 2318:Spondweni virus group 1974:Marisma mosquito virus 1829:Mosquito-borne viruses 1612: 1576: 1081: 1009: 969: 906: 824: 765: 628: 554: 527:, single-stranded RNA 508: 382:Parramatta River virus 5489:10.1073/pnas.93.2.548 5273:Thisyakorn U (2014). 5062:Ann Microbiol (Paris) 2866:Japanese encephalitis 2848: 2190:Kokobera virus group 2016:Panmunjeom flavivirus 1590: 1571:Phylogenetic tree of 1570: 1079: 1000: 967: 937:Conserved hairpin cHP 900: 818: 760: 623: 615:S-adenosyl methionine 546: 503: 5695:virus classification 5628:13 June 2010 at the 5242:10.1128/JVI.00432-19 5185:10.1099/jgv.0.000430 4945:Emerging Infect. Dis 4896:Emerging Infect. Dis 4828:Emerging Infect. Dis 4663:10.1128/JVI.00432-19 4222:10.1128/JVI.01159-10 3011:Archives of Virology 2857:The very successful 2607:Phnom Penh bat virus 2487:Entebbe virus group 1406:Phnom Penh bat virus 1133:broadened the known 829:secondary structures 774:untranslated regions 507:structure and genome 202:Virus classification 56:improve this article 8677:Permutotetraviridae 6436:Orthopolintovirales 5911:Malacoherpesviridae 5571:10.1038/nrmicro1928 5515:Kalitzky M (2006). 5480:1996PNAS...93..548Z 5230:Journal of Virology 5036:talk.ictvonline.org 4781:2015PLoSO..1017849M 4712:2018Natur.556..197S 4601:2015PLoSO..1046037C 4216:(21): 11407–11417. 4210:Journal of Virology 4157:2014Sci...344..307C 4098:Biochemical Journal 3689:10.1101/gad.1444206 3490:2017PLoSO..1270462S 3431:2011PLoSO...625795H 3374:1985Sci...229..726R 3293:(Pt 6): 1272–1280. 2966:2016Sci...352..467S 2703:Haslams Creek virus 2530:Cowbone Ridge virus 2376:Fitzroy river virus 2076:Dengue virus group 1916:Culiseta flavivirus 1813:Saumarez Reef virus 1706:Gadgets Gully virus 1462:Saumarez Reef virus 1273:Gadgets Gully virus 1238:Cowbone Ridge virus 772:contains 5' and 3' 590:guanylyltransferase 432:electron microscope 6995:Malgrandaviricetes 6630:Sphaerolipoviridae 6616:Matshushitaviridae 6208:Nucleocytoviricota 4583:Conway MJ (2015). 4497:10.1093/ve/veac085 4110:10.1042/BJ20140456 3537:PLOS Negl Trop Dis 3231:Cadwallader Colden 2855: 2732:Menghai flavivirus 2583:Carey Island virus 2575:Bukalasa bat virus 2517:Modoc virus group 2443:Bukulasa bat virus 2423:Yellow fever virus 2219:Ntaya virus group 1960:Kamiti River virus 1837:Cell fusing clade 1648:Mogiana tick virus 1613: 1583:Tick-borne viruses 1577: 1532:Yellow fever virus 1231:Carey Island virus 1217:Bukalasa bat virus 1155:Ondatra zibethicus 1082: 1010: 970: 907: 825: 766: 639:to release mature 629: 598:RNA triphosphatase 586:RNA triphosphatase 555: 523:Flaviviruses have 509: 455:yellow fever virus 426:, single-stranded 396:means 'yellow' in 368:and several other 362:yellow fever virus 165:Yellow fever virus 9618: 9617: 9491:Taxon identifiers 9482: 9481: 9478: 9477: 9474: 9473: 9470: 9469: 9466: 9465: 9462: 9461: 9458: 9457: 9454: 9453: 9344: 9343: 9340: 9339: 9336: 9335: 9332: 9331: 9328: 9327: 9324: 9323: 9206: 9205: 9202: 9201: 9198: 9197: 9194: 9193: 9190: 9189: 9186: 9185: 9182: 9181: 9152:Yunchangviricetes 9145: 9144: 8988: 8987: 8951: 8950: 8907: 8906: 8793: 8792: 8705: 8704: 8701: 8700: 8697: 8696: 8693: 8692: 8660: 8659: 8656: 8655: 8597: 8596: 8351: 8350: 8347: 8346: 8310: 8309: 8273: 8272: 8236: 8235: 8138: 8137: 8134: 8133: 8111:Carmotetraviridae 8083: 8082: 8039: 8038: 8002: 8001: 7986:Gammaflexiviridae 7979:Deltaflexiviridae 7965:Alphaflexiviridae 7858:Alphatetraviridae 7779: 7778: 7775: 7774: 7771: 7770: 7767: 7766: 7723: 7722: 7719: 7718: 7643: 7642: 7639: 7638: 7602: 7601: 7565: 7564: 7514:Chrymotiviricetes 7447: 7446: 7443: 7442: 7439: 7438: 7399: 7398: 7395: 7394: 7391: 7390: 7387: 7386: 7328: 7327: 7324: 7323: 7320: 7319: 7276: 7275: 7172:Bacilladnaviridae 7133: 7132: 7129: 7128: 7092: 7091: 7033: 7032: 7029: 7028: 7025: 7024: 6966: 6965: 6962: 6961: 6958: 6957: 6856: 6855: 6852: 6851: 6848: 6847: 6814:Portogloboviridae 6727: 6726: 6651: 6650: 6647: 6646: 6643: 6642: 6639: 6638: 6566: 6565: 6562: 6561: 6558: 6557: 6455: 6454: 6418: 6417: 6377:Preplasmiviricota 6370: 6369: 6366: 6365: 6271: 6270: 6179: 6178: 6175: 6174: 6171: 6170: 6167: 6166: 6075: 6074: 6071: 6070: 6067: 6066: 6063: 6062: 5970:Autographiviridae 5924: 5923: 5920: 5919: 5897:Alloherpesviridae 5836: 5835: 5832: 5831: 5828: 5827: 5824: 5823: 5545:978-1-904455-92-9 5526:978-1-904933-22-9 5398:978-1-68367-283-8 5341:978-0-12-800098-4 5322:Yauch LE (2014). 5120:10.3390/v13071368 5002:10.1002/jmv.23856 4706:(7700): 197–202. 4309:(11): 2029–2040. 4151:(6181): 307–310. 4026:10.1021/bi952398v 3879:Cell Host Microbe 3194:10.3390/v13112116 3143:10.3390/v12090964 3069:978-1-904455-92-9 2960:(6284): 467–470. 2562:San Perlita virus 2492:Entebbe bat virus 2415:Wesselsbron virus 2232:Baiyangdian virus 2039:Aroa virus group 1747:Louping ill virus 1609:Louping-ill virus 1511:Wesselsbron virus 1455:San Perlita virus 1357:Louping ill virus 1266:Entebbe bat virus 1002:Phylogenetic tree 847:viral replication 811:Flavivirus 3' UTR 804: 786:Flavivirus 5' UTR 779: 750: 749: 594:methyltransferase 511:Flaviviruses are 325: 324: 132: 131: 124: 106: 16:(Redirected from 9653: 9611: 9610: 9598: 9597: 9585: 9584: 9572: 9571: 9559: 9558: 9546: 9545: 9533: 9532: 9531: 9518: 9517: 9516: 9486: 9408: 9397: 9386: 9375: 9364: 9356:dsDNA-RT viruses 9350: 9279: 9268: 9257: 9246: 9235: 9227:ssRNA-RT viruses 9221: 9217: 9158: 9001: 8969:Serpentovirales 8964: 8942:Orthomyxoviridae 8920: 8870:Peribunyaviridae 8806: 8769: 8763:Chunqiuviricetes 8758: 8747: 8736: 8725: 8717:(–)ssRNA viruses 8711: 8610: 8453:Nanghoshaviridae 8375: 8364: 8338:Botourmiaviridae 8323: 8286: 8280:Howeltoviricetes 8249: 8243:Amabiliviricetes 8162: 8151: 8096: 8052: 8015: 7972:Betaflexiviridae 7843: 7832: 7821: 7810: 7799: 7791:(+)ssRNA viruses 7785: 7703:Picobirnaviridae 7667: 7661:Duplopiviricetes 7656: 7615: 7609:Vidaverviricetes 7578: 7572:Resentoviricetes 7542:Megabirnaviridae 7520: 7509: 7503:Duplornaviricota 7498: 7487: 7476: 7462: 7458: 7363: 7357:Huolimaviricetes 7352: 7341: 7289: 7283:Repensiviricetes 7157: 7146: 7140:Cressdnaviricota 7105: 7068: 7057: 7046: 7001: 6990: 6979: 6920: 6909: 6898: 6887: 6876: 6862: 6671: 6660: 6601: 6590: 6579: 6468: 6462:Tectiliviricetes 6431: 6425:Polintoviricetes 6399:Priklausovirales 6394: 6383: 6357:Marseilleviridae 6284: 6225: 6214: 6203: 6192: 6158:Papillomaviridae 6148:Zurhausenvirales 6121: 6110: 6099: 6088: 5963:Ackermannviridae 5948: 5937: 5882: 5871: 5860: 5849: 5815:Tristromaviridae 5786:Lipothrixviridae 5771: 5760: 5749: 5738: 5727: 5713: 5709: 5684: 5677: 5670: 5661: 5592: 5582: 5549: 5530: 5511: 5501: 5491: 5458: 5448: 5403: 5402: 5382: 5376: 5375: 5373: 5371: 5360: 5354: 5353: 5319: 5313: 5312: 5302: 5270: 5264: 5263: 5253: 5221: 5206: 5205: 5187: 5178:(5): 1087–1093. 5163: 5157: 5156: 5150: 5142: 5132: 5122: 5098: 5092: 5091: 5085: 5077: 5053: 5047: 5046: 5044: 5042: 5028: 5022: 5021: 4996:(7): 1181–1187. 4985: 4979: 4978: 4968: 4936: 4930: 4929: 4919: 4887: 4881: 4879: 4877: 4875: 4860: 4854: 4853: 4843: 4819: 4813: 4812: 4802: 4792: 4760: 4754: 4753: 4747: 4739: 4691: 4685: 4684: 4674: 4642: 4633: 4632: 4622: 4612: 4595:(12): e0146037. 4580: 4574: 4573: 4563: 4539: 4533: 4532: 4526: 4518: 4508: 4476: 4470: 4469: 4459: 4450:(8): 1867–1876. 4435: 4429: 4428: 4418: 4386: 4380: 4379: 4351: 4345: 4344: 4334: 4294: 4288: 4287: 4258: 4252: 4251: 4241: 4201: 4195: 4194: 4184: 4136: 4130: 4129: 4093: 4087: 4086: 4076: 4059:(5): 2170–2182. 4044: 4038: 4037: 4009: 4003: 4002: 3992: 3960: 3954: 3953: 3943: 3911: 3905: 3904: 3894: 3870: 3861: 3860: 3850: 3818: 3809: 3808: 3798: 3766: 3760: 3759: 3749: 3717: 3711: 3710: 3700: 3668: 3662: 3661: 3633: 3627: 3626: 3616: 3606: 3604:10.3390/v3091739 3582: 3573: 3572: 3562: 3552: 3528: 3522: 3521: 3511: 3501: 3469: 3463: 3462: 3452: 3442: 3410: 3401: 3400: 3398: 3396: 3368:(4715): 726–33. 3353: 3344: 3343: 3341: 3339: 3324: 3313: 3312: 3302: 3278: 3269: 3223: 3217: 3216: 3206: 3196: 3172: 3166: 3165: 3155: 3145: 3121: 3115: 3114: 3104: 3080: 3074: 3073: 3051: 3045: 3044: 3026: 3002: 2996: 2995: 2985: 2945: 2939: 2938: 2936: 2934: 2919: 2903:vaccine platform 2810:Aedes flavivirus 2768:Palm Creek virus 2481:Tamana bat virus 2457:Rabensburg virus 2272:Layer flavivirus 2203:New Mapoon virus 2102:Cacipacore virus 2052:Bussuquara virus 2023:Quang Binh virus 2009:Palm Creek virus 1907:Wang Thong virus 1886:Culex flavivirus 1872:Calbertado virus 1842:Aedes flavivirus 1771:Royal Farm virus 1691:Absettarov virus 1591:Distribution of 1554:Sorted by vector 1427:Royal Farm virus 1224:Cacipacore virus 1117:and her aborted 712:Replication site 694: 613:and enhanced by 378:Palm Creek virus 372:which may cause 210: 209: 196: 176: 150: 136: 127: 120: 116: 113: 107: 105: 64: 40: 32: 27:Genus of viruses 21: 9661: 9660: 9656: 9655: 9654: 9652: 9651: 9650: 9621: 9620: 9619: 9614: 9606: 9601: 9593: 9588: 9580: 9575: 9567: 9562: 9554: 9549: 9541: 9536: 9527: 9526: 9521: 9512: 9511: 9506: 9493: 9483: 9450: 9428: 9402:Revtraviricetes 9358: 9320: 9273:Revtraviricetes 9229: 9178: 9141: 9108:Paramyxoviridae 9056:Mononegavirales 9049: 9030:Crepuscuviridae 8984: 8947: 8925:Articulavirales 8914:Insthoviricetes 8903: 8789: 8752:Negarnaviricota 8719: 8689: 8652: 8630: 8604:Stelpaviricetes 8593: 8557: 8552:Polycipiviridae 8545:Dicistroviridae 8486: 8369:Pisoniviricetes 8343: 8306: 8269: 8232: 8203: 8130: 8090:Tolucaviricetes 8079: 8035: 8020:Amarillovirales 7998: 7948: 7908:Closteroviridae 7891:Martellivirales 7884: 7826:Kitrinoviricota 7793: 7763: 7747:Polymycoviridae 7715: 7635: 7598: 7561: 7470: 7435: 7423:Finnlakeviridae 7383: 7378:Pleolipoviridae 7316: 7272: 7250: 7221: 7199: 7177: 7125: 7099:Quintoviricetes 7088: 7021: 6954: 6870: 6844: 6723: 6705: 6635: 6606:Halopanivirales 6554: 6532: 6510: 6488: 6451: 6414: 6388:Maveriviricetes 6362: 6326: 6304: 6299:Phycodnaviridae 6267: 6245: 6219:Pokkesviricetes 6163: 6141: 6115:Papovaviricetes 6059: 6026:Rountreeviridae 5916: 5820: 5798: 5721: 5698: 5688: 5630:Wayback Machine 5599: 5552: 5546: 5534:Shi PY (2012). 5533: 5527: 5514: 5461: 5414: 5411: 5409:Further reading 5406: 5399: 5384: 5383: 5379: 5369: 5367: 5362: 5361: 5357: 5342: 5321: 5320: 5316: 5272: 5271: 5267: 5223: 5222: 5209: 5165: 5164: 5160: 5143: 5100: 5099: 5095: 5078: 5055: 5054: 5050: 5040: 5038: 5030: 5029: 5025: 4987: 4986: 4982: 4938: 4937: 4933: 4889: 4888: 4884: 4873: 4871: 4862: 4861: 4857: 4821: 4820: 4816: 4775:(2): e0117849. 4762: 4761: 4757: 4740: 4693: 4692: 4688: 4644: 4643: 4636: 4582: 4581: 4577: 4541: 4540: 4536: 4519: 4478: 4477: 4473: 4437: 4436: 4432: 4388: 4387: 4383: 4353: 4352: 4348: 4296: 4295: 4291: 4260: 4259: 4255: 4203: 4202: 4198: 4138: 4137: 4133: 4095: 4094: 4090: 4046: 4045: 4041: 4020:(13): 4222–30. 4011: 4010: 4006: 3962: 3961: 3957: 3913: 3912: 3908: 3872: 3871: 3864: 3833:(13): 8303–15. 3820: 3819: 3812: 3781:(11): 6631–43. 3768: 3767: 3763: 3719: 3718: 3714: 3683:(16): 2238–49. 3670: 3669: 3665: 3635: 3634: 3630: 3584: 3583: 3576: 3530: 3529: 3525: 3484:(1): e0170462. 3471: 3470: 3466: 3412: 3411: 3404: 3394: 3392: 3355: 3354: 3347: 3337: 3335: 3334:on 17 June 2015 3326: 3325: 3316: 3280: 3279: 3272: 3224: 3220: 3174: 3173: 3169: 3123: 3122: 3118: 3082: 3081: 3077: 3070: 3053: 3052: 3048: 3004: 3003: 2999: 2947: 2946: 2942: 2932: 2930: 2921: 2920: 2916: 2912: 2882:dengue vaccines 2843: 2838: 2837: 2836: 2805: 2627: 2615:Rio Bravo virus 2591:Dakar bat virus 2554:Sal Vieja virus 2476: 2436:Batu cave virus 2368:Edge Hill virus 2323:Spondweni virus 2211:Stratford virus 2174:West Nile virus 1995:Nienokoue virus 1953:Ilomantsi virus 1831: 1698:Deer tick virus 1640:Krasnodar virus 1585: 1563: 1560: 1556: 1551: 1518:West Nile virus 1448:Sal Vieja virus 1420:Rio Bravo virus 1259:Edge Hill virus 1245:Dakar bat virus 1169: 1164: 1139:West Nile virus 1123:West Nile virus 1111:West Nile virus 1102:West Nile virus 1100:studies of the 1091:West Nile virus 995: 962: 939: 838:West Nile virus 813: 807: 788: 782: 755: 709:Release details 573:. The cellular 547:Replication of 541: 521: 498: 350:West Nile virus 335:Orthoflavivirus 281:Amarillovirales 257:Kitrinoviricota 204: 192: 128: 117: 111: 108: 65: 63: 53: 41: 28: 23: 22: 15: 12: 11: 5: 9659: 9657: 9649: 9648: 9643: 9638: 9633: 9623: 9622: 9616: 9615: 9613: 9612: 9599: 9586: 9573: 9560: 9547: 9534: 9519: 9503: 9501: 9495: 9494: 9489: 9480: 9479: 9476: 9475: 9472: 9471: 9468: 9467: 9464: 9463: 9460: 9459: 9456: 9455: 9452: 9451: 9449: 9448: 9445:Caulimoviridae 9440: 9438: 9430: 9429: 9427: 9426: 9423:Hepadnaviridae 9418: 9416: 9405: 9394: 9391:Artverviricota 9383: 9372: 9360: 9359: 9353: 9346: 9345: 9342: 9341: 9338: 9337: 9334: 9333: 9330: 9329: 9326: 9325: 9322: 9321: 9319: 9318: 9311: 9304: 9297: 9289: 9287: 9276: 9265: 9262:Artverviricota 9254: 9243: 9231: 9230: 9224: 9214: 9208: 9207: 9204: 9203: 9200: 9199: 9196: 9195: 9192: 9191: 9188: 9187: 9184: 9183: 9180: 9179: 9177: 9176: 9168: 9166: 9163:Goujianvirales 9155: 9147: 9146: 9143: 9142: 9140: 9139: 9132: 9125: 9118: 9111: 9104: 9097: 9090: 9083: 9076: 9069: 9061: 9059: 9051: 9050: 9048: 9047: 9040: 9033: 9026: 9019: 9011: 9009: 9006:Jingchuvirales 8998: 8995:Monjiviricetes 8990: 8989: 8986: 8985: 8983: 8982: 8974: 8972: 8961: 8958:Milneviricetes 8953: 8952: 8949: 8948: 8946: 8945: 8938: 8930: 8928: 8917: 8909: 8908: 8905: 8904: 8902: 8901: 8894: 8887: 8880: 8873: 8866: 8859: 8852: 8849:Leishbuviridae 8845: 8838: 8831: 8824: 8816: 8814: 8803: 8800:Ellioviricetes 8795: 8794: 8791: 8790: 8788: 8787: 8779: 8777: 8766: 8755: 8744: 8733: 8721: 8720: 8714: 8707: 8706: 8703: 8702: 8699: 8698: 8695: 8694: 8691: 8690: 8688: 8687: 8684:Sarthroviridae 8680: 8668: 8666: 8662: 8661: 8658: 8657: 8654: 8653: 8651: 8650: 8642: 8640: 8632: 8631: 8629: 8628: 8620: 8618: 8607: 8599: 8598: 8595: 8594: 8592: 8591: 8584: 8577: 8574:Alvernaviridae 8569: 8567: 8559: 8558: 8556: 8555: 8548: 8541: 8534: 8527: 8520: 8517:Solinviviridae 8513: 8506: 8503:Picornaviridae 8498: 8496: 8493:Picornavirales 8488: 8487: 8485: 8484: 8477: 8470: 8463: 8460:Nanhypoviridae 8456: 8449: 8442: 8435: 8432:Medioniviridae 8428: 8421: 8414: 8407: 8404:Cremegaviridae 8400: 8393: 8385: 8383: 8372: 8361: 8353: 8352: 8349: 8348: 8345: 8344: 8342: 8341: 8333: 8331: 8320: 8312: 8311: 8308: 8307: 8305: 8304: 8296: 8294: 8283: 8275: 8274: 8271: 8270: 8268: 8267: 8259: 8257: 8254:Wolframvirales 8246: 8238: 8237: 8234: 8233: 8231: 8230: 8223: 8215: 8213: 8205: 8204: 8202: 8201: 8194: 8187: 8180: 8172: 8170: 8159: 8148: 8140: 8139: 8136: 8135: 8132: 8131: 8129: 8128: 8121: 8114: 8106: 8104: 8093: 8085: 8084: 8081: 8080: 8078: 8077: 8074:Sinhaliviridae 8070: 8062: 8060: 8049: 8046:Magsaviricetes 8041: 8040: 8037: 8036: 8034: 8033: 8025: 8023: 8012: 8009:Flasuviricetes 8004: 8003: 8000: 7999: 7997: 7996: 7989: 7982: 7975: 7968: 7960: 7958: 7950: 7949: 7947: 7946: 7939: 7932: 7925: 7918: 7915:Endornaviridae 7911: 7904: 7896: 7894: 7886: 7885: 7883: 7882: 7875: 7868: 7861: 7853: 7851: 7840: 7829: 7818: 7807: 7795: 7794: 7788: 7781: 7780: 7777: 7776: 7773: 7772: 7769: 7768: 7765: 7764: 7762: 7761: 7758:Botybirnavirus 7750: 7743: 7731: 7729: 7725: 7724: 7721: 7720: 7717: 7716: 7714: 7713: 7710:Partitiviridae 7706: 7699: 7692: 7689:Curvulaviridae 7685: 7677: 7675: 7664: 7653: 7645: 7644: 7641: 7640: 7637: 7636: 7634: 7633: 7625: 7623: 7612: 7604: 7603: 7600: 7599: 7597: 7596: 7588: 7586: 7575: 7567: 7566: 7563: 7562: 7560: 7559: 7552: 7545: 7538: 7530: 7528: 7517: 7506: 7495: 7484: 7472: 7471: 7465: 7455: 7449: 7448: 7445: 7444: 7441: 7440: 7437: 7436: 7434: 7433: 7426: 7419: 7407: 7405: 7401: 7400: 7397: 7396: 7393: 7392: 7389: 7388: 7385: 7384: 7382: 7381: 7373: 7371: 7360: 7349: 7338: 7330: 7329: 7326: 7325: 7322: 7321: 7318: 7317: 7315: 7314: 7307: 7299: 7297: 7294:Geplafuvirales 7286: 7278: 7277: 7274: 7273: 7271: 7270: 7267:Redondoviridae 7262: 7260: 7252: 7251: 7249: 7248: 7241: 7233: 7231: 7223: 7222: 7220: 7219: 7211: 7209: 7201: 7200: 7198: 7197: 7189: 7187: 7179: 7178: 7176: 7175: 7167: 7165: 7154: 7143: 7135: 7134: 7131: 7130: 7127: 7126: 7124: 7123: 7115: 7113: 7102: 7094: 7093: 7090: 7089: 7087: 7086: 7078: 7076: 7065: 7054: 7043: 7035: 7034: 7031: 7030: 7027: 7026: 7023: 7022: 7020: 7019: 7011: 7009: 6998: 6987: 6976: 6968: 6967: 6964: 6963: 6960: 6959: 6956: 6955: 6953: 6952: 6949:Plectroviridae 6945: 6942:Paulinoviridae 6938: 6930: 6928: 6917: 6914:Faserviricetes 6906: 6903:Hofneiviricota 6895: 6884: 6872: 6871: 6865: 6858: 6857: 6854: 6853: 6850: 6849: 6846: 6845: 6843: 6842: 6835: 6824: 6817: 6810: 6807:Polydnaviridae 6803: 6796: 6789: 6782: 6775: 6772:Globuloviridae 6768: 6765:Fuselloviridae 6761: 6754: 6751:Bicaudaviridae 6747: 6744:Ampullaviridae 6735: 6733: 6729: 6728: 6725: 6724: 6722: 6721: 6713: 6711: 6707: 6706: 6704: 6703: 6696: 6693:Hytrosaviridae 6689: 6681: 6679: 6668: 6665:Naldaviricetes 6657: 6653: 6652: 6649: 6648: 6645: 6644: 6641: 6640: 6637: 6636: 6634: 6633: 6626: 6619: 6611: 6609: 6598: 6595:Laserviricetes 6587: 6584:Dividoviricota 6576: 6568: 6567: 6564: 6563: 6560: 6559: 6556: 6555: 6553: 6552: 6549:Corticoviridae 6544: 6542: 6534: 6533: 6531: 6530: 6522: 6520: 6512: 6511: 6509: 6508: 6500: 6498: 6490: 6489: 6487: 6486: 6478: 6476: 6465: 6457: 6456: 6453: 6452: 6450: 6449: 6441: 6439: 6428: 6420: 6419: 6416: 6415: 6413: 6412: 6404: 6402: 6391: 6380: 6372: 6371: 6368: 6367: 6364: 6363: 6361: 6360: 6353: 6346: 6338: 6336: 6333:Pimascovirales 6328: 6327: 6325: 6324: 6316: 6314: 6306: 6305: 6303: 6302: 6294: 6292: 6281: 6273: 6272: 6269: 6268: 6266: 6265: 6257: 6255: 6247: 6246: 6244: 6243: 6235: 6233: 6222: 6211: 6200: 6189: 6181: 6180: 6177: 6176: 6173: 6172: 6169: 6168: 6165: 6164: 6162: 6161: 6153: 6151: 6143: 6142: 6140: 6139: 6136:Polyomaviridae 6131: 6129: 6118: 6107: 6096: 6085: 6077: 6076: 6073: 6072: 6069: 6068: 6065: 6064: 6061: 6060: 6058: 6057: 6050: 6043: 6036: 6033:Salasmaviridae 6029: 6022: 6015: 6008: 6005:Herelleviridae 6001: 5994: 5991:Drexlerviridae 5987: 5984:Demerecviridae 5980: 5973: 5966: 5958: 5956: 5945: 5942:Caudoviricetes 5934: 5926: 5925: 5922: 5921: 5918: 5917: 5915: 5914: 5907: 5900: 5892: 5890: 5879: 5876:Herviviricetes 5868: 5857: 5854:Heunggongvirae 5846: 5838: 5837: 5834: 5833: 5830: 5829: 5826: 5825: 5822: 5821: 5819: 5818: 5810: 5808: 5800: 5799: 5797: 5796: 5789: 5781: 5779: 5776:Ligamenvirales 5768: 5757: 5746: 5735: 5723: 5722: 5716: 5706: 5700: 5699: 5689: 5687: 5686: 5679: 5672: 5664: 5658: 5657: 5652: 5647: 5642: 5637: 5632: 5617: 5614:Dengueinfo.org 5611: 5605: 5598: 5597:External links 5595: 5594: 5593: 5565:(9): 699–708. 5550: 5544: 5531: 5525: 5512: 5474:(2): 548–553. 5459: 5410: 5407: 5405: 5404: 5397: 5377: 5355: 5340: 5314: 5265: 5207: 5158: 5093: 5048: 5023: 4980: 4931: 4882: 4855: 4814: 4755: 4686: 4634: 4575: 4554:(2): 309–325. 4534: 4491:(2): veac085. 4471: 4430: 4381: 4356:Virus Research 4346: 4289: 4270:(1–2): 11–21. 4253: 4196: 4131: 4104:(2): 215–230. 4088: 4039: 4004: 3975:(9): 7510–22. 3955: 3926:(10): 5133–8. 3906: 3862: 3810: 3761: 3712: 3663: 3628: 3597:(9): 1739–56. 3574: 3523: 3464: 3425:(10): e25795. 3402: 3345: 3314: 3270: 3254: 3253: 3218: 3167: 3116: 3075: 3068: 3046: 2997: 2940: 2913: 2911: 2908: 2842: 2839: 2835: 2834: 2827: 2820: 2813: 2804: 2801: 2800: 2799: 2792: 2785: 2778: 2771: 2764: 2757: 2750: 2743: 2739:Nakiwogo virus 2735: 2728: 2721: 2714: 2710:Mac Peak virus 2706: 2699: 2692: 2684: 2677: 2670: 2663: 2660:Donggang virus 2656: 2649: 2642: 2635: 2626: 2623: 2622: 2621: 2620: 2619: 2611: 2603: 2595: 2587: 2579: 2568: 2567: 2566: 2558: 2550: 2542: 2534: 2526: 2515: 2514: 2513: 2505: 2504: 2503: 2485: 2475: 2472: 2471: 2470: 2469: 2468: 2465:Sitiawan virus 2461: 2453: 2446: 2439: 2429: 2428: 2427: 2419: 2411: 2407:Uganda S virus 2403: 2395: 2387: 2379: 2372: 2364: 2356: 2348: 2337: 2336: 2335: 2327: 2316: 2315: 2314: 2306: 2299: 2295:Sitiawan virus 2291: 2283: 2275: 2268: 2260: 2252: 2244: 2236: 2228: 2217: 2216: 2215: 2207: 2199: 2195:Kokobera virus 2188: 2187: 2186: 2178: 2170: 2162: 2154: 2153: 2152: 2137: 2129: 2121: 2114: 2110:Koutango virus 2106: 2095: 2094: 2093: 2089:Kedougou virus 2085: 2074: 2073: 2072: 2068:Naranjal virus 2064: 2056: 2048: 2037: 2036: 2035: 2034: 2033: 2019: 2012: 2005: 1998: 1991: 1988:Nhumirim virus 1984: 1981:Nakiwogo virus 1977: 1970: 1963: 1956: 1949: 1948: 1947: 1940: 1926: 1923:Donggang virus 1919: 1912: 1911: 1910: 1903: 1889: 1882: 1879:Chaoyang virus 1875: 1868: 1865:Barkedji virus 1861: 1854: 1853: 1852: 1845: 1830: 1827: 1826: 1825: 1821:Tyuleniy virus 1817: 1809: 1801: 1786: 1785: 1784: 1783: 1775: 1767: 1763:Powassan virus 1759: 1751: 1743: 1735: 1734: 1733: 1717: 1710: 1702: 1694: 1684: 1676: 1668: 1660: 1652: 1644: 1636: 1628: 1605:Powassan virus 1584: 1581: 1565: 1561: 1558: 1557: 1555: 1552: 1550: 1549: 1542: 1535: 1528: 1521: 1514: 1507: 1500: 1497:Uganda S virus 1493: 1490:Tyuleniy virus 1486: 1479: 1472: 1465: 1458: 1451: 1444: 1437: 1430: 1423: 1416: 1413:Powassan virus 1409: 1402: 1395: 1388: 1381: 1374: 1367: 1360: 1353: 1346: 1339: 1336:Koutango virus 1332: 1329:Kokobera virus 1325: 1322:Kedougou virus 1318: 1311: 1304: 1297: 1290: 1283: 1276: 1269: 1262: 1255: 1248: 1241: 1234: 1227: 1220: 1213: 1206: 1199: 1192: 1185: 1177: 1168: 1165: 1163: 1160: 1089:diverged from 1062:Endeis spinosa 994: 991: 961: 958: 938: 935: 926: 925: 895: 894: 881: 880: 861: 860: 809:Main article: 806: 803: 784:Main article: 781: 778: 754: 751: 748: 747: 744: 741: 738: 735: 732: 729: 726: 720: 719: 716: 713: 710: 707: 704: 703:Tissue tropism 701: 698: 540: 537: 525:positive-sense 520: 517: 497: 494: 424:positive-sense 342:in the family 323: 322: 314: 313: 309: 308: 301: 297: 296: 289: 285: 284: 277: 273: 272: 269:Flasuviricetes 265: 261: 260: 253: 249: 248: 241: 237: 236: 229: 222: 221: 216: 212: 211: 198: 197: 185:viral envelope 178: 177: 169: 168: 152: 151: 143: 142: 130: 129: 44: 42: 35: 26: 24: 14: 13: 10: 9: 6: 4: 3: 2: 9658: 9647: 9644: 9642: 9639: 9637: 9634: 9632: 9629: 9628: 9626: 9609: 9604: 9600: 9596: 9591: 9587: 9583: 9578: 9574: 9570: 9565: 9561: 9557: 9552: 9548: 9544: 9539: 9535: 9530: 9524: 9520: 9515: 9509: 9505: 9504: 9502: 9500: 9496: 9492: 9487: 9447: 9446: 9442: 9441: 9439: 9437: 9436: 9431: 9425: 9424: 9420: 9419: 9417: 9415: 9414: 9413:Blubervirales 9409: 9406: 9404: 9403: 9398: 9395: 9393: 9392: 9387: 9384: 9382: 9381: 9376: 9373: 9371: 9370: 9365: 9361: 9357: 9351: 9347: 9317: 9316: 9312: 9310: 9309: 9308:Pseudoviridae 9305: 9303: 9302: 9298: 9296: 9295: 9294:Belpaoviridae 9291: 9290: 9288: 9286: 9285: 9280: 9277: 9275: 9274: 9269: 9266: 9264: 9263: 9258: 9255: 9253: 9252: 9247: 9244: 9242: 9241: 9236: 9232: 9228: 9222: 9218: 9215: 9213: 9209: 9175: 9174: 9170: 9169: 9167: 9165: 9164: 9159: 9156: 9154: 9153: 9148: 9138: 9137: 9133: 9131: 9130: 9126: 9124: 9123: 9122:Rhabdoviridae 9119: 9117: 9116: 9115:Pneumoviridae 9112: 9110: 9109: 9105: 9103: 9102: 9098: 9096: 9095: 9094:Mymonaviridae 9091: 9089: 9088: 9084: 9082: 9081: 9077: 9075: 9074: 9070: 9068: 9067: 9063: 9062: 9060: 9058: 9057: 9052: 9046: 9045: 9044:Natareviridae 9041: 9039: 9038: 9034: 9032: 9031: 9027: 9025: 9024: 9020: 9018: 9017: 9013: 9012: 9010: 9008: 9007: 9002: 8999: 8997: 8996: 8991: 8981: 8980: 8976: 8975: 8973: 8971: 8970: 8965: 8962: 8960: 8959: 8954: 8944: 8943: 8939: 8937: 8936: 8935:Amnoonviridae 8932: 8931: 8929: 8927: 8926: 8921: 8918: 8916: 8915: 8910: 8900: 8899: 8898:Wupedeviridae 8895: 8893: 8892: 8888: 8886: 8885: 8884:Phenuiviridae 8881: 8879: 8878: 8877:Phasmaviridae 8874: 8872: 8871: 8867: 8865: 8864: 8860: 8858: 8857: 8853: 8851: 8850: 8846: 8844: 8843: 8839: 8837: 8836: 8832: 8830: 8829: 8825: 8823: 8822: 8818: 8817: 8815: 8813: 8812: 8807: 8804: 8802: 8801: 8796: 8786: 8785: 8781: 8780: 8778: 8776: 8775: 8770: 8767: 8765: 8764: 8759: 8756: 8754: 8753: 8748: 8745: 8743: 8742: 8741:Orthornavirae 8737: 8734: 8732: 8731: 8726: 8722: 8718: 8712: 8708: 8686: 8685: 8681: 8679: 8678: 8673: 8670: 8669: 8667: 8663: 8649: 8648: 8644: 8643: 8641: 8639: 8638: 8637:Stellavirales 8633: 8627: 8626: 8622: 8621: 8619: 8617: 8616: 8615:Patatavirales 8611: 8608: 8606: 8605: 8600: 8590: 8589: 8588:Solemoviridae 8585: 8583: 8582: 8578: 8576: 8575: 8571: 8570: 8568: 8566: 8565: 8564:Sobelivirales 8560: 8554: 8553: 8549: 8547: 8546: 8542: 8540: 8539: 8535: 8533: 8532: 8528: 8526: 8525: 8524:Caliciviridae 8521: 8519: 8518: 8514: 8512: 8511: 8507: 8505: 8504: 8500: 8499: 8497: 8495: 8494: 8489: 8483: 8482: 8481:Tobaniviridae 8478: 8476: 8475: 8471: 8469: 8468: 8464: 8462: 8461: 8457: 8455: 8454: 8450: 8448: 8447: 8446:Mononiviridae 8443: 8441: 8440: 8439:Mesoniviridae 8436: 8434: 8433: 8429: 8427: 8426: 8425:Gresnaviridae 8422: 8420: 8419: 8418:Euroniviridae 8415: 8413: 8412: 8411:Coronaviridae 8408: 8406: 8405: 8401: 8399: 8398: 8397:Arteriviridae 8394: 8392: 8391: 8390:Abyssoviridae 8387: 8386: 8384: 8382: 8381: 8376: 8373: 8371: 8370: 8365: 8362: 8360: 8359: 8354: 8340: 8339: 8335: 8334: 8332: 8330: 8329: 8324: 8321: 8319: 8318: 8313: 8303: 8302: 8298: 8297: 8295: 8293: 8292: 8291:Cryppavirales 8287: 8284: 8282: 8281: 8276: 8266: 8265: 8261: 8260: 8258: 8256: 8255: 8250: 8247: 8245: 8244: 8239: 8229: 8228: 8227:Steitzviridae 8224: 8222: 8221: 8217: 8216: 8214: 8212: 8211: 8206: 8200: 8199: 8198:Solspiviridae 8195: 8193: 8192: 8188: 8186: 8185: 8181: 8179: 8178: 8177:Atkinsviridae 8174: 8173: 8171: 8169: 8168: 8163: 8160: 8158: 8157: 8156:Leviviricetes 8152: 8149: 8147: 8146: 8145:Lenarviricota 8141: 8127: 8126: 8125:Tombusviridae 8122: 8120: 8119: 8115: 8113: 8112: 8108: 8107: 8105: 8103: 8102: 8097: 8094: 8092: 8091: 8086: 8076: 8075: 8071: 8069: 8068: 8064: 8063: 8061: 8059: 8058: 8057:Nodamuvirales 8053: 8050: 8048: 8047: 8042: 8032: 8031: 8027: 8026: 8024: 8022: 8021: 8016: 8013: 8011: 8010: 8005: 7995: 7994: 7990: 7988: 7987: 7983: 7981: 7980: 7976: 7974: 7973: 7969: 7967: 7966: 7962: 7961: 7959: 7957: 7956: 7951: 7945: 7944: 7940: 7938: 7937: 7933: 7931: 7930: 7926: 7924: 7923: 7919: 7917: 7916: 7912: 7910: 7909: 7905: 7903: 7902: 7898: 7897: 7895: 7893: 7892: 7887: 7881: 7880: 7879:Matonaviridae 7876: 7874: 7873: 7869: 7867: 7866: 7862: 7860: 7859: 7855: 7854: 7852: 7850: 7849: 7848:Hepelivirales 7844: 7841: 7839: 7838: 7837:Alsuviricetes 7833: 7830: 7828: 7827: 7822: 7819: 7817: 7816: 7815:Orthornavirae 7811: 7808: 7806: 7805: 7800: 7796: 7792: 7786: 7782: 7760: 7759: 7754: 7751: 7749: 7748: 7744: 7742: 7741: 7736: 7733: 7732: 7730: 7726: 7712: 7711: 7707: 7705: 7704: 7700: 7698: 7697: 7693: 7691: 7690: 7686: 7684: 7683: 7682:Amalgaviridae 7679: 7678: 7676: 7674: 7673: 7668: 7665: 7663: 7662: 7657: 7654: 7652: 7651: 7646: 7632: 7631: 7627: 7626: 7624: 7622: 7621: 7616: 7613: 7611: 7610: 7605: 7595: 7594: 7590: 7589: 7587: 7585: 7584: 7579: 7576: 7574: 7573: 7568: 7558: 7557: 7553: 7551: 7550: 7549:Quadriviridae 7546: 7544: 7543: 7539: 7537: 7536: 7535:Chrysoviridae 7532: 7531: 7529: 7527: 7526: 7525:Ghabrivirales 7521: 7518: 7516: 7515: 7510: 7507: 7505: 7504: 7499: 7496: 7494: 7493: 7492:Orthornavirae 7488: 7485: 7483: 7482: 7477: 7473: 7469: 7468:dsRNA viruses 7463: 7459: 7456: 7454: 7450: 7432: 7431: 7427: 7425: 7424: 7420: 7418: 7417: 7416:Anelloviridae 7412: 7409: 7408: 7406: 7402: 7380: 7379: 7375: 7374: 7372: 7370: 7369: 7368:Haloruvirales 7364: 7361: 7359: 7358: 7353: 7350: 7348: 7347: 7342: 7339: 7337: 7336: 7331: 7313: 7312: 7311:Genomoviridae 7308: 7306: 7305: 7304:Geminiviridae 7301: 7300: 7298: 7296: 7295: 7290: 7287: 7285: 7284: 7279: 7269: 7268: 7264: 7263: 7261: 7259: 7258: 7253: 7247: 7246: 7242: 7240: 7239: 7238:Metaxyviridae 7235: 7234: 7232: 7230: 7229: 7224: 7218: 7217: 7213: 7212: 7210: 7208: 7207: 7202: 7196: 7195: 7191: 7190: 7188: 7186: 7185: 7180: 7174: 7173: 7169: 7168: 7166: 7164: 7163: 7158: 7155: 7153: 7152: 7151:Arfiviricetes 7147: 7144: 7142: 7141: 7136: 7122: 7121: 7117: 7116: 7114: 7112: 7111: 7106: 7103: 7101: 7100: 7095: 7085: 7084: 7080: 7079: 7077: 7075: 7074: 7069: 7066: 7064: 7063: 7058: 7055: 7053: 7052: 7051:Cossaviricota 7047: 7044: 7042: 7041: 7036: 7018: 7017: 7013: 7012: 7010: 7008: 7007: 7002: 6999: 6997: 6996: 6991: 6988: 6986: 6985: 6980: 6977: 6975: 6974: 6969: 6951: 6950: 6946: 6944: 6943: 6939: 6937: 6936: 6932: 6931: 6929: 6927: 6926: 6925:Tubulavirales 6921: 6918: 6916: 6915: 6910: 6907: 6905: 6904: 6899: 6896: 6894: 6893: 6888: 6885: 6883: 6882: 6877: 6873: 6869: 6868:ssDNA viruses 6863: 6859: 6841: 6840: 6839:Rhizidiovirus 6836: 6834: 6833: 6828: 6825: 6823: 6822: 6821:Thaspiviridae 6818: 6816: 6815: 6811: 6809: 6808: 6804: 6802: 6801: 6800:Plasmaviridae 6797: 6795: 6794: 6790: 6788: 6787: 6786:Halspiviridae 6783: 6781: 6780: 6776: 6774: 6773: 6769: 6767: 6766: 6762: 6760: 6759: 6755: 6753: 6752: 6748: 6746: 6745: 6740: 6737: 6736: 6734: 6730: 6720: 6719: 6715: 6714: 6712: 6708: 6702: 6701: 6697: 6695: 6694: 6690: 6688: 6687: 6686:Baculoviridae 6683: 6682: 6680: 6678: 6677: 6672: 6669: 6667: 6666: 6661: 6658: 6654: 6632: 6631: 6627: 6625: 6624: 6623:Simuloviridae 6620: 6618: 6617: 6613: 6612: 6610: 6608: 6607: 6602: 6599: 6597: 6596: 6591: 6588: 6586: 6585: 6580: 6577: 6575: 6574: 6573:Helvetiavirae 6569: 6551: 6550: 6546: 6545: 6543: 6541: 6540: 6535: 6529: 6528: 6524: 6523: 6521: 6519: 6518: 6513: 6507: 6506: 6502: 6501: 6499: 6497: 6496: 6495:Kalamavirales 6491: 6485: 6484: 6480: 6479: 6477: 6475: 6474: 6473:Belfryvirales 6469: 6466: 6464: 6463: 6458: 6448: 6447: 6446:Adintoviridae 6443: 6442: 6440: 6438: 6437: 6432: 6429: 6427: 6426: 6421: 6411: 6410: 6409:Lavidaviridae 6406: 6405: 6403: 6401: 6400: 6395: 6392: 6390: 6389: 6384: 6381: 6379: 6378: 6373: 6359: 6358: 6354: 6352: 6351: 6347: 6345: 6344: 6340: 6339: 6337: 6335: 6334: 6329: 6323: 6322: 6318: 6317: 6315: 6313: 6312: 6311:Imitervirales 6307: 6301: 6300: 6296: 6295: 6293: 6291: 6290: 6285: 6282: 6280: 6279: 6278:Megaviricetes 6274: 6264: 6263: 6259: 6258: 6256: 6254: 6253: 6248: 6242: 6241: 6237: 6236: 6234: 6232: 6231: 6226: 6223: 6221: 6220: 6215: 6212: 6210: 6209: 6204: 6201: 6199: 6198: 6193: 6190: 6188: 6187: 6182: 6160: 6159: 6155: 6154: 6152: 6150: 6149: 6144: 6138: 6137: 6133: 6132: 6130: 6128: 6127: 6126:Sepolyvirales 6122: 6119: 6117: 6116: 6111: 6108: 6106: 6105: 6104:Cossaviricota 6100: 6097: 6095: 6094: 6089: 6086: 6084: 6083: 6078: 6056: 6055: 6054:Zobellviridae 6051: 6049: 6048: 6044: 6042: 6041: 6040:Schitoviridae 6037: 6035: 6034: 6030: 6028: 6027: 6023: 6021: 6020: 6016: 6014: 6013: 6009: 6007: 6006: 6002: 6000: 5999: 5998:Guelinviridae 5995: 5993: 5992: 5988: 5986: 5985: 5981: 5979: 5978: 5974: 5972: 5971: 5967: 5965: 5964: 5960: 5959: 5957: 5955: 5954: 5949: 5946: 5944: 5943: 5938: 5935: 5933: 5932: 5927: 5913: 5912: 5908: 5906: 5905: 5904:Herpesviridae 5901: 5899: 5898: 5894: 5893: 5891: 5889: 5888: 5887:Herpesvirales 5883: 5880: 5878: 5877: 5872: 5869: 5867: 5866: 5865:Peploviricota 5861: 5858: 5856: 5855: 5850: 5847: 5845: 5844: 5843:Duplodnaviria 5839: 5817: 5816: 5812: 5811: 5809: 5807: 5806: 5801: 5795: 5794: 5790: 5788: 5787: 5783: 5782: 5780: 5778: 5777: 5772: 5769: 5767: 5766: 5765:Tokiviricetes 5761: 5758: 5756: 5755: 5754:Taleaviricota 5750: 5747: 5745: 5744: 5739: 5736: 5734: 5733: 5728: 5724: 5720: 5719:dsDNA viruses 5714: 5710: 5707: 5705: 5701: 5696: 5692: 5685: 5680: 5678: 5673: 5671: 5666: 5665: 5662: 5656: 5653: 5651: 5648: 5646: 5643: 5641: 5638: 5636: 5633: 5631: 5627: 5624: 5622: 5618: 5615: 5612: 5609: 5606: 5604: 5601: 5600: 5596: 5590: 5586: 5581: 5576: 5572: 5568: 5564: 5560: 5556: 5551: 5547: 5541: 5537: 5532: 5528: 5522: 5518: 5513: 5509: 5505: 5500: 5495: 5490: 5485: 5481: 5477: 5473: 5469: 5465: 5460: 5456: 5452: 5447: 5442: 5438: 5434: 5430: 5426: 5422: 5420: 5413: 5412: 5408: 5400: 5394: 5390: 5389: 5381: 5378: 5365: 5359: 5356: 5351: 5347: 5343: 5337: 5333: 5329: 5325: 5318: 5315: 5310: 5306: 5301: 5296: 5292: 5288: 5284: 5280: 5276: 5269: 5266: 5261: 5257: 5252: 5247: 5243: 5239: 5235: 5231: 5227: 5220: 5218: 5216: 5214: 5212: 5208: 5203: 5199: 5195: 5191: 5186: 5181: 5177: 5173: 5169: 5162: 5159: 5154: 5148: 5140: 5136: 5131: 5126: 5121: 5116: 5112: 5108: 5104: 5097: 5094: 5089: 5083: 5075: 5071: 5068:(2): 239–44. 5067: 5063: 5059: 5052: 5049: 5037: 5033: 5027: 5024: 5019: 5015: 5011: 5007: 5003: 4999: 4995: 4991: 4984: 4981: 4976: 4972: 4967: 4962: 4958: 4954: 4951:(8): 1531–3. 4950: 4946: 4942: 4935: 4932: 4927: 4923: 4918: 4913: 4909: 4905: 4902:(8): 1534–6. 4901: 4897: 4893: 4886: 4883: 4870: 4866: 4859: 4856: 4851: 4847: 4842: 4837: 4833: 4829: 4825: 4818: 4815: 4810: 4806: 4801: 4796: 4791: 4786: 4782: 4778: 4774: 4770: 4766: 4759: 4756: 4751: 4745: 4737: 4733: 4729: 4725: 4721: 4717: 4713: 4709: 4705: 4701: 4697: 4690: 4687: 4682: 4678: 4673: 4668: 4664: 4660: 4656: 4652: 4648: 4641: 4639: 4635: 4630: 4626: 4621: 4616: 4611: 4606: 4602: 4598: 4594: 4590: 4586: 4579: 4576: 4571: 4567: 4562: 4557: 4553: 4549: 4545: 4538: 4535: 4530: 4524: 4516: 4512: 4507: 4502: 4498: 4494: 4490: 4486: 4482: 4475: 4472: 4467: 4463: 4458: 4453: 4449: 4445: 4441: 4434: 4431: 4426: 4422: 4417: 4412: 4408: 4404: 4400: 4396: 4392: 4385: 4382: 4377: 4373: 4369: 4365: 4361: 4357: 4350: 4347: 4342: 4338: 4333: 4328: 4324: 4320: 4316: 4312: 4308: 4304: 4300: 4293: 4290: 4285: 4281: 4277: 4273: 4269: 4265: 4257: 4254: 4249: 4245: 4240: 4235: 4231: 4227: 4223: 4219: 4215: 4211: 4207: 4200: 4197: 4192: 4188: 4183: 4178: 4174: 4170: 4166: 4162: 4158: 4154: 4150: 4146: 4142: 4135: 4132: 4127: 4123: 4119: 4115: 4111: 4107: 4103: 4099: 4092: 4089: 4084: 4080: 4075: 4070: 4066: 4062: 4058: 4054: 4050: 4043: 4040: 4035: 4031: 4027: 4023: 4019: 4015: 4008: 4005: 4000: 3996: 3991: 3986: 3982: 3978: 3974: 3970: 3966: 3959: 3956: 3951: 3947: 3942: 3937: 3933: 3929: 3925: 3921: 3917: 3910: 3907: 3902: 3898: 3893: 3888: 3885:(6): 579–91. 3884: 3880: 3876: 3869: 3867: 3863: 3858: 3854: 3849: 3844: 3840: 3836: 3832: 3828: 3824: 3817: 3815: 3811: 3806: 3802: 3797: 3792: 3788: 3784: 3780: 3776: 3772: 3765: 3762: 3757: 3753: 3748: 3743: 3739: 3735: 3732:(1): 170–85. 3731: 3727: 3723: 3716: 3713: 3708: 3704: 3699: 3694: 3690: 3686: 3682: 3678: 3674: 3667: 3664: 3659: 3655: 3651: 3647: 3643: 3639: 3632: 3629: 3624: 3620: 3615: 3610: 3605: 3600: 3596: 3592: 3588: 3581: 3579: 3575: 3570: 3566: 3561: 3556: 3551: 3546: 3542: 3538: 3534: 3527: 3524: 3519: 3515: 3510: 3505: 3500: 3495: 3491: 3487: 3483: 3479: 3475: 3468: 3465: 3460: 3456: 3451: 3446: 3441: 3436: 3432: 3428: 3424: 3420: 3416: 3409: 3407: 3403: 3391: 3387: 3383: 3379: 3375: 3371: 3367: 3363: 3359: 3352: 3350: 3346: 3333: 3329: 3323: 3321: 3319: 3315: 3310: 3306: 3301: 3296: 3292: 3288: 3284: 3277: 3275: 3271: 3267: 3263: 3259: 3251: 3247: 3243: 3239: 3238: 3236: 3235:Benjamin Rush 3232: 3228: 3227:John Mitchell 3222: 3219: 3214: 3210: 3205: 3200: 3195: 3190: 3186: 3182: 3178: 3171: 3168: 3163: 3159: 3154: 3149: 3144: 3139: 3135: 3131: 3127: 3120: 3117: 3112: 3108: 3103: 3098: 3094: 3090: 3086: 3079: 3076: 3071: 3065: 3061: 3057: 3050: 3047: 3042: 3038: 3034: 3030: 3025: 3020: 3016: 3012: 3008: 3001: 2998: 2993: 2989: 2984: 2979: 2975: 2971: 2967: 2963: 2959: 2955: 2951: 2944: 2941: 2928: 2924: 2918: 2915: 2909: 2906: 2904: 2900: 2897: 2893: 2886: 2883: 2878: 2875: 2871: 2867: 2862: 2860: 2852: 2847: 2840: 2833: 2832: 2828: 2826: 2825: 2821: 2819: 2818: 2814: 2812: 2811: 2807: 2806: 2802: 2798: 2797: 2793: 2791: 2790: 2786: 2784: 2783: 2779: 2777: 2776: 2772: 2770: 2769: 2765: 2763: 2762: 2758: 2756: 2755: 2754:Nounané virus 2751: 2749: 2748: 2744: 2741: 2740: 2736: 2734: 2733: 2729: 2727: 2726: 2722: 2720: 2719: 2715: 2712: 2711: 2707: 2705: 2704: 2700: 2698: 2697: 2693: 2690: 2689: 2688:Karumba virus 2685: 2683: 2682: 2678: 2676: 2675: 2671: 2669: 2668: 2664: 2662: 2661: 2657: 2655: 2654: 2650: 2648: 2647: 2643: 2641: 2640: 2636: 2634: 2633: 2629: 2628: 2624: 2617: 2616: 2612: 2609: 2608: 2604: 2601: 2600: 2596: 2593: 2592: 2588: 2585: 2584: 2580: 2577: 2576: 2572: 2571: 2569: 2564: 2563: 2559: 2556: 2555: 2551: 2548: 2547: 2543: 2540: 2539: 2538:Jutiapa virus 2535: 2532: 2531: 2527: 2524: 2523: 2519: 2518: 2516: 2511: 2510: 2506: 2502: 2501: 2500:Sokoluk virus 2497: 2496: 2494: 2493: 2489: 2488: 2486: 2483: 2482: 2478: 2477: 2473: 2467: 2466: 2462: 2459: 2458: 2454: 2452: 2451: 2447: 2445: 2444: 2440: 2438: 2437: 2433: 2432: 2430: 2425: 2424: 2420: 2417: 2416: 2412: 2409: 2408: 2404: 2401: 2400: 2396: 2393: 2392: 2388: 2385: 2384: 2380: 2378: 2377: 2373: 2370: 2369: 2365: 2362: 2361: 2360:Bouboui virus 2357: 2354: 2353: 2349: 2346: 2345: 2341: 2340: 2338: 2333: 2332: 2328: 2325: 2324: 2320: 2319: 2317: 2312: 2311: 2310:Tembusu virus 2307: 2305: 2304: 2300: 2297: 2296: 2292: 2289: 2288: 2284: 2281: 2280: 2276: 2274: 2273: 2269: 2266: 2265: 2264:Jiangsu virus 2261: 2258: 2257: 2253: 2250: 2249: 2245: 2242: 2241: 2237: 2234: 2233: 2229: 2226: 2225: 2221: 2220: 2218: 2213: 2212: 2208: 2205: 2204: 2200: 2197: 2196: 2192: 2191: 2189: 2184: 2183: 2182:Yaounde virus 2179: 2176: 2175: 2171: 2168: 2167: 2163: 2160: 2159: 2155: 2151: 2150: 2146: 2145: 2143: 2142: 2138: 2135: 2134: 2130: 2127: 2126: 2122: 2120: 2119: 2115: 2112: 2111: 2107: 2104: 2103: 2099: 2098: 2096: 2091: 2090: 2086: 2083: 2082: 2078: 2077: 2075: 2070: 2069: 2065: 2062: 2061: 2057: 2054: 2053: 2049: 2046: 2045: 2041: 2040: 2038: 2032: 2031: 2027: 2026: 2025: 2024: 2020: 2018: 2017: 2013: 2011: 2010: 2006: 2004: 2003: 2002:Nounané virus 1999: 1997: 1996: 1992: 1990: 1989: 1985: 1983: 1982: 1978: 1976: 1975: 1971: 1969: 1968: 1964: 1962: 1961: 1957: 1955: 1954: 1950: 1946: 1945: 1941: 1939: 1938: 1934: 1933: 1932: 1931: 1927: 1925: 1924: 1920: 1918: 1917: 1913: 1909: 1908: 1904: 1902: 1901: 1897: 1896: 1895: 1894: 1890: 1888: 1887: 1883: 1881: 1880: 1876: 1874: 1873: 1869: 1867: 1866: 1862: 1860: 1859: 1855: 1851: 1850: 1846: 1844: 1843: 1839: 1838: 1836: 1835: 1833: 1832: 1828: 1823: 1822: 1818: 1815: 1814: 1810: 1807: 1806: 1802: 1799: 1798: 1794: 1793: 1792: 1790: 1781: 1780: 1776: 1773: 1772: 1768: 1765: 1764: 1760: 1757: 1756: 1752: 1749: 1748: 1744: 1741: 1740: 1736: 1731: 1730: 1726: 1725: 1723: 1722: 1718: 1716: 1715: 1711: 1708: 1707: 1703: 1700: 1699: 1695: 1693: 1692: 1688: 1687: 1685: 1682: 1681: 1677: 1674: 1673: 1669: 1666: 1665: 1664:Sokuluk virus 1661: 1658: 1657: 1653: 1650: 1649: 1645: 1642: 1641: 1637: 1634: 1633: 1629: 1626: 1625: 1621: 1620: 1619: 1617: 1610: 1606: 1602: 1598: 1594: 1589: 1582: 1580: 1574: 1569: 1564: 1553: 1548: 1547: 1543: 1541: 1540: 1536: 1534: 1533: 1529: 1527: 1526: 1525:Yaounde virus 1522: 1520: 1519: 1515: 1513: 1512: 1508: 1506: 1505: 1501: 1499: 1498: 1494: 1492: 1491: 1487: 1485: 1484: 1480: 1478: 1477: 1476:Tembusu virus 1473: 1471: 1470: 1466: 1464: 1463: 1459: 1457: 1456: 1452: 1450: 1449: 1445: 1443: 1442: 1438: 1436: 1435: 1431: 1429: 1428: 1424: 1422: 1421: 1417: 1415: 1414: 1410: 1408: 1407: 1403: 1401: 1400: 1396: 1394: 1393: 1389: 1387: 1386: 1382: 1380: 1379: 1375: 1373: 1372: 1368: 1366: 1365: 1361: 1359: 1358: 1354: 1352: 1351: 1347: 1345: 1344: 1340: 1338: 1337: 1333: 1331: 1330: 1326: 1324: 1323: 1319: 1317: 1316: 1312: 1310: 1309: 1308:Jutiapa virus 1305: 1303: 1302: 1298: 1296: 1295: 1291: 1289: 1288: 1284: 1282: 1281: 1277: 1275: 1274: 1270: 1268: 1267: 1263: 1261: 1260: 1256: 1254: 1253: 1249: 1247: 1246: 1242: 1240: 1239: 1235: 1233: 1232: 1228: 1226: 1225: 1221: 1219: 1218: 1214: 1212: 1211: 1210:Bouboui virus 1207: 1205: 1204: 1200: 1198: 1197: 1193: 1191: 1190: 1186: 1184: 1183: 1179: 1178: 1176: 1174: 1171:In the genus 1166: 1161: 1159: 1157: 1156: 1150: 1146: 1144: 1140: 1136: 1132: 1128: 1124: 1120: 1116: 1112: 1108: 1103: 1099: 1095: 1092: 1088: 1078: 1074: 1072: 1068: 1063: 1060: 1055: 1051: 1049: 1044: 1042: 1038: 1033: 1031: 1027: 1026: 1021: 1020: 1014: 1007: 1003: 999: 992: 990: 987: 983: 979: 975: 966: 959: 957: 955: 951: 948: 944: 936: 934: 932: 924: 921: 920: 919: 917: 912: 904: 899: 893: 890: 889: 888: 886: 879: 876: 875: 874: 872: 871: 866: 859: 856: 855: 854: 852: 848: 842: 840: 839: 834: 830: 822: 817: 812: 802: 799: 795: 794: 787: 777: 775: 771: 763: 759: 752: 745: 742: 739: 736: 733: 730: 727: 725: 722: 721: 718:Transmission 717: 715:Assembly site 714: 711: 708: 706:Entry details 705: 702: 699: 696: 695: 692: 690: 685: 683: 678: 676: 672: 668: 664: 660: 658: 654: 650: 646: 645:autocatalytic 642: 638: 634: 627: 622: 618: 616: 612: 608: 603: 599: 595: 591: 587: 582: 580: 576: 572: 568: 567:(poly-A) tail 564: 560: 552: 551: 545: 538: 536: 534: 530: 526: 518: 516: 514: 506: 502: 495: 493: 491: 487: 482: 480: 475: 474:unpasteurised 470: 468: 467: 462: 461: 456: 452: 451:dead end host 448: 444: 440: 435: 433: 429: 425: 421: 417: 414: 410: 405: 403: 399: 395: 390: 387: 383: 379: 375: 371: 367: 363: 359: 355: 351: 347: 346: 341: 337: 336: 331: 330: 321: 320: 315: 310: 307: 306: 302: 299: 298: 295: 294: 290: 287: 286: 283: 282: 278: 275: 274: 271: 270: 266: 263: 262: 259: 258: 254: 251: 250: 247: 246: 245:Orthornavirae 242: 239: 238: 235: 234: 230: 227: 224: 223: 220: 217: 214: 213: 208: 203: 199: 195: 190: 186: 183: 179: 175: 170: 167: 166: 161: 158: 153: 149: 144: 141: 137: 134: 126: 123: 115: 104: 101: 97: 94: 90: 87: 83: 80: 76: 73: –  72: 68: 67:Find sources: 61: 57: 51: 50: 45:This article 43: 39: 34: 33: 30: 19: 9646:Virus genera 9641:Flaviviridae 9631:Flaviviruses 9498: 9443: 9435:Ortervirales 9433: 9421: 9411: 9400: 9389: 9380:Pararnavirae 9378: 9367: 9315:Retroviridae 9313: 9306: 9299: 9292: 9284:Ortervirales 9282: 9271: 9260: 9251:Pararnavirae 9249: 9238: 9171: 9161: 9150: 9136:Xinmoviridae 9134: 9127: 9120: 9113: 9106: 9101:Nyamiviridae 9099: 9092: 9087:Lispiviridae 9085: 9078: 9073:Bornaviridae 9071: 9064: 9054: 9042: 9037:Myriaviridae 9035: 9028: 9021: 9016:Aliusviridae 9014: 9004: 8993: 8977: 8967: 8956: 8940: 8933: 8923: 8912: 8896: 8891:Tospoviridae 8889: 8882: 8875: 8868: 8863:Nairoviridae 8861: 8854: 8847: 8842:Hantaviridae 8840: 8833: 8828:Arenaviridae 8826: 8821:Cruliviridae 8819: 8811:Bunyavirales 8809: 8798: 8782: 8772: 8761: 8750: 8739: 8728: 8682: 8675: 8671: 8647:Astroviridae 8645: 8635: 8623: 8613: 8602: 8586: 8581:Barnaviridae 8579: 8572: 8562: 8550: 8543: 8536: 8529: 8522: 8515: 8510:Marnaviridae 8508: 8501: 8491: 8479: 8472: 8467:Olifoviridae 8465: 8458: 8451: 8444: 8437: 8430: 8423: 8416: 8409: 8402: 8395: 8388: 8378: 8367: 8358:Pisuviricota 8356: 8336: 8328:Ourlivirales 8326: 8317:Miaviricetes 8315: 8299: 8289: 8278: 8264:Narnaviridae 8262: 8252: 8241: 8225: 8220:Blumeviridae 8218: 8210:Timlovirales 8208: 8196: 8191:Fiersviridae 8189: 8182: 8175: 8167:Norzivirales 8165: 8154: 8143: 8123: 8118:Luteoviridae 8116: 8109: 8099: 8088: 8072: 8065: 8055: 8044: 8030:Flaviviridae 8028: 8018: 8007: 7991: 7984: 7977: 7970: 7963: 7953: 7943:Virgaviridae 7941: 7934: 7927: 7920: 7913: 7906: 7901:Bromoviridae 7899: 7889: 7877: 7870: 7863: 7856: 7846: 7835: 7824: 7813: 7802: 7756: 7752: 7745: 7740:Birnaviridae 7738: 7734: 7708: 7701: 7694: 7687: 7680: 7672:Durnavirales 7670: 7659: 7650:Pisuviricota 7648: 7630:Cystoviridae 7628: 7620:Mindivirales 7618: 7607: 7591: 7581: 7570: 7554: 7547: 7540: 7533: 7523: 7512: 7501: 7490: 7479: 7430:Spiraviridae 7428: 7421: 7414: 7410: 7376: 7366: 7355: 7346:Saleviricota 7344: 7333: 7309: 7302: 7292: 7281: 7265: 7257:Recrevirales 7255: 7243: 7236: 7228:Mulpavirales 7226: 7216:Smacoviridae 7214: 7206:Cremevirales 7204: 7194:Circoviridae 7192: 7184:Cirlivirales 7182: 7170: 7162:Baphyvirales 7160: 7149: 7138: 7120:Parvoviridae 7118: 7110:Piccovirales 7108: 7097: 7083:Bidnaviridae 7081: 7071: 7062:Mouviricetes 7060: 7049: 7040:Shotokuvirae 7038: 7016:Microviridae 7014: 7006:Petitvirales 7004: 6993: 6984:Phixviricota 6982: 6971: 6947: 6940: 6933: 6923: 6912: 6901: 6890: 6881:Monodnaviria 6879: 6837: 6832:Dinodnavirus 6830: 6826: 6819: 6812: 6805: 6798: 6793:Ovaliviridae 6791: 6784: 6779:Guttaviridae 6777: 6770: 6763: 6758:Clavaviridae 6756: 6749: 6742: 6738: 6716: 6698: 6691: 6684: 6674: 6663: 6628: 6621: 6614: 6604: 6593: 6582: 6571: 6547: 6537: 6527:Adenoviridae 6525: 6515: 6505:Tectiviridae 6503: 6493: 6483:Turriviridae 6481: 6471: 6460: 6444: 6434: 6423: 6407: 6397: 6386: 6375: 6355: 6350:Iridoviridae 6348: 6341: 6331: 6319: 6309: 6297: 6287: 6276: 6260: 6252:Chitovirales 6250: 6240:Asfarviridae 6238: 6228: 6217: 6206: 6197:Bamfordvirae 6195: 6186:Varidnaviria 6184: 6156: 6146: 6134: 6124: 6113: 6102: 6093:Shotokuvirae 6091: 6082:Monodnaviria 6080: 6052: 6047:Siphoviridae 6045: 6038: 6031: 6024: 6017: 6010: 6003: 5996: 5989: 5982: 5977:Chaseviridae 5975: 5968: 5961: 5953:Caudovirales 5951: 5940: 5929: 5909: 5902: 5895: 5885: 5874: 5863: 5852: 5841: 5813: 5805:Primavirales 5803: 5791: 5784: 5774: 5763: 5752: 5741: 5730: 5623:: Flavivirus 5620: 5562: 5558: 5535: 5516: 5471: 5467: 5431:(1): 73–83. 5428: 5424: 5418: 5387: 5380: 5368:. Retrieved 5358: 5323: 5317: 5282: 5278: 5268: 5233: 5229: 5175: 5171: 5161: 5147:cite journal 5110: 5106: 5096: 5082:cite journal 5065: 5061: 5051: 5039:. Retrieved 5035: 5026: 4993: 4989: 4983: 4948: 4944: 4934: 4899: 4895: 4885: 4872:. Retrieved 4868: 4858: 4831: 4827: 4817: 4772: 4768: 4758: 4744:cite journal 4703: 4699: 4689: 4654: 4650: 4592: 4588: 4578: 4551: 4547: 4537: 4523:cite journal 4488: 4484: 4474: 4447: 4443: 4433: 4401:(1): 73–83. 4398: 4394: 4384: 4359: 4355: 4349: 4306: 4302: 4292: 4267: 4263: 4256: 4213: 4209: 4199: 4148: 4144: 4134: 4101: 4097: 4091: 4056: 4052: 4042: 4017: 4014:Biochemistry 4013: 4007: 3972: 3968: 3958: 3923: 3919: 3909: 3882: 3878: 3830: 3826: 3778: 3774: 3764: 3729: 3725: 3715: 3680: 3676: 3666: 3644:(2): 290–9. 3641: 3637: 3631: 3594: 3590: 3543:(9): e1820. 3540: 3536: 3526: 3481: 3477: 3467: 3422: 3418: 3393:. Retrieved 3365: 3361: 3336:. Retrieved 3332:the original 3328:"Viral Zone" 3290: 3286: 3265: 3261: 3249: 3245: 3221: 3187:(11): 2116. 3184: 3180: 3170: 3133: 3129: 3119: 3092: 3088: 3078: 3055: 3049: 3014: 3010: 3000: 2957: 2953: 2943: 2931:. Retrieved 2929:. March 2019 2926: 2917: 2888: 2879: 2863: 2856: 2850: 2829: 2822: 2815: 2808: 2794: 2787: 2780: 2773: 2766: 2759: 2752: 2745: 2737: 2730: 2723: 2716: 2708: 2701: 2694: 2686: 2679: 2672: 2665: 2658: 2653:Cuacua virus 2651: 2644: 2639:Bamaga virus 2637: 2630: 2613: 2605: 2597: 2589: 2581: 2573: 2560: 2552: 2544: 2536: 2528: 2520: 2509:Yokose virus 2507: 2498: 2490: 2479: 2463: 2455: 2448: 2441: 2434: 2421: 2413: 2405: 2397: 2391:Saboya virus 2389: 2381: 2374: 2366: 2358: 2352:Bamaga virus 2350: 2342: 2329: 2321: 2308: 2301: 2293: 2285: 2277: 2270: 2262: 2254: 2248:Ilheus virus 2246: 2238: 2230: 2224:Bagaza virus 2222: 2209: 2201: 2193: 2180: 2172: 2164: 2156: 2147: 2139: 2131: 2125:Ilheus virus 2123: 2118:Kunjin virus 2116: 2108: 2100: 2087: 2081:Dengue virus 2079: 2066: 2060:Iguape virus 2058: 2050: 2042: 2028: 2021: 2014: 2007: 2000: 1993: 1986: 1979: 1972: 1965: 1958: 1951: 1942: 1935: 1928: 1921: 1914: 1905: 1898: 1891: 1884: 1877: 1870: 1863: 1856: 1847: 1840: 1819: 1811: 1805:Meaban virus 1803: 1795: 1787: 1777: 1769: 1761: 1753: 1745: 1739:Langat virus 1737: 1727: 1719: 1714:Karshi virus 1712: 1704: 1696: 1689: 1678: 1670: 1662: 1654: 1646: 1638: 1630: 1622: 1614: 1608: 1607:(POWV), and 1604: 1600: 1596: 1592: 1578: 1572: 1562: 1544: 1539:Yokose virus 1537: 1530: 1523: 1516: 1509: 1502: 1495: 1488: 1481: 1474: 1467: 1460: 1453: 1446: 1439: 1434:Saboya virus 1432: 1425: 1418: 1411: 1404: 1397: 1390: 1383: 1376: 1369: 1364:Meaban virus 1362: 1355: 1350:Langat virus 1348: 1341: 1334: 1327: 1320: 1313: 1306: 1299: 1292: 1285: 1280:Ilheus virus 1278: 1271: 1264: 1257: 1252:Dengue virus 1250: 1243: 1236: 1229: 1222: 1215: 1208: 1201: 1196:Bagaza virus 1194: 1187: 1180: 1172: 1170: 1153: 1148: 1147: 1138: 1127:killer whale 1122: 1110: 1101: 1098:Phylogenetic 1096: 1090: 1087:Kunjin virus 1086: 1083: 1070: 1066: 1061: 1056: 1052: 1045: 1034: 1023: 1017: 1015: 1011: 1005: 985: 977: 973: 971: 946: 940: 927: 922: 911:Dengue virus 910: 908: 902: 891: 884: 882: 877: 868: 865:hairpin loop 862: 857: 851:endonuclease 843: 836: 832: 826: 820: 797: 793:Dengue virus 791: 789: 769: 767: 761: 723: 700:Host details 686: 682:Flaviviridae 681: 679: 662: 661: 630: 583: 556: 548: 522: 510: 504: 485: 483: 471: 464: 460:dengue virus 458: 454: 436: 420:nucleic acid 416:nucleocapsid 406: 404:in victims. 393: 391: 374:encephalitis 354:dengue virus 345:Flaviviridae 343: 334: 333: 328: 327: 326: 317: 304: 303: 293:Flaviviridae 292: 280: 268: 256: 244: 232: 225: 215:(unranked): 181: 163: 139: 133: 118: 109: 99: 92: 85: 78: 71:"Flavivirus" 66: 54:Please help 49:verification 46: 29: 18:Flaviviruses 9523:Wikispecies 9301:Metaviridae 9080:Filoviridae 9066:Artoviridae 8979:Aspiviridae 8856:Mypoviridae 8835:Fimoviridae 8625:Potyviridae 8538:Secoviridae 8531:Iflaviridae 8474:Roniviridae 8380:Nidovirales 8301:Mitoviridae 8184:Duinviridae 8101:Tolivirales 8067:Nodaviridae 7993:Tymoviridae 7955:Tymovirales 7936:Togaviridae 7929:Mayoviridae 7922:Kitaviridae 7872:Hepeviridae 7865:Benyviridae 7696:Hypoviridae 7556:Totiviridae 7245:Nanoviridae 7073:Polivirales 6973:Sangervirae 6718:Nimaviridae 6700:Nudiviridae 6676:Lefavirales 6539:Vinavirales 6517:Rowavirales 6343:Ascoviridae 6321:Mimiviridae 6289:Algavirales 6230:Asfuvirales 6019:Podoviridae 5931:Uroviricota 5793:Rudiviridae 5743:Zilligvirae 5113:(7): 1368. 5041:16 November 4874:10 February 4444:J Gen Virol 3395:14 November 3268:(2): 132–6. 3258:Saul Jarcho 3095:: 272–283. 2899:Eilat virus 2747:Nanay virus 2696:Hanko virus 2632:Assam virus 2546:Modoc virus 2450:Nanay virus 2399:Sepik virus 2383:Jugra virus 2344:Banzi virus 2287:Rocio virus 2279:Ntaya virus 2166:Usutu virus 2149:Alfuy virus 1967:Lammi virus 1930:Hanko virus 1656:Ngoye virus 1632:Kadam virus 1504:Usutu virus 1469:Sepik virus 1392:Ntaya virus 1371:Modoc virus 1315:Kadam virus 1301:Jugra virus 1203:Banzi virus 1141:to include 972:Subgenomic 954:start codon 916:translation 641:polypeptide 626:ER membrane 600:within its 579:polyprotein 571:replication 443:arboviruses 413:icosahedral 386:vertebrates 380:(PCV), and 9625:Categories 9529:Flavivirus 9499:Flavivirus 9173:Yueviridae 9129:Sunviridae 9023:Chuviridae 8784:Qinviridae 8665:Unassigned 7728:Unassigned 7593:Reoviridae 7583:Reovirales 7404:Unassigned 7335:Trapavirae 6935:Inoviridae 6732:Unassigned 6710:Unassigned 6656:Unassigned 6262:Poxviridae 6012:Myoviridae 5419:Flavivirus 5285:(1): 3–9. 4548:Arch Virol 4485:Virus Evol 3252:: 181–215. 3136:(9): 964. 3017:(9): 224. 2910:References 2896:alphavirus 2851:flavivirus 2522:Apoi virus 2331:Zika virus 2303:T'Ho virus 2044:Aroa virus 1797:Kama virus 1573:Flavivirus 1546:Zika virus 1189:Aroa virus 1182:Apoi virus 1173:Flavivirus 1135:host range 1059:sea spider 1006:Flavivirus 986:flavivirus 978:flavivirus 974:flavivirus 947:Flavivirus 931:pseudoknot 905:DB element 903:Flavivirus 885:Flavivirus 833:flavivirus 821:flavivirus 798:Flavivirus 770:Flavivirus 762:Flavivirus 724:Flavivirus 691:and bite. 663:Flavivirus 633:translated 539:Life cycle 505:Zika virus 486:flavivirus 479:contagious 466:zika virus 366:Zika virus 332:, renamed 329:Flavivirus 305:Flavivirus 182:Zika virus 160:micrograph 140:Flavivirus 82:newspapers 9369:Riboviria 9240:Riboviria 8774:Muvirales 8730:Riboviria 7804:Riboviria 7481:Riboviria 6892:Loebvirae 5732:Adnaviria 5691:Baltimore 5621:Viralzone 5370:1 October 5366:. WHO.int 4869:The Horse 4736:256771319 4362:: 53–61. 4323:1355-8382 4230:0022-538X 4173:0036-8075 4118:0264-6021 3677:Genes Dev 3033:1432-8798 1616:Mammalian 1143:cetaceans 993:Evolution 743:Cytoplasm 740:Cytoplasm 737:Secretion 637:proteases 559:cytoplasm 513:enveloped 496:Structure 439:arthropod 409:enveloped 240:Kingdom: 233:Riboviria 9514:Q1165479 9508:Wikidata 8672:Families 7735:Families 7411:Families 6739:Families 5626:Archived 5589:18587411 5350:24373316 5309:24757522 5260:31068424 5202:43127614 5194:26878841 5139:34372574 5018:36929638 5010:24259273 4975:21801643 4926:21801644 4850:15338540 4809:25719412 4769:PLOS ONE 4728:29618816 4681:31068424 4629:26717191 4589:PLOS ONE 4570:16172840 4515:36533146 4466:11457992 4376:25660582 4341:23006624 4284:23755934 4248:20719943 4191:24744377 4126:25102029 4083:16474125 3969:J. Virol 3950:15113895 3920:J. Virol 3901:19064258 3857:15956576 3827:J. Virol 3805:15890901 3756:18234265 3726:Virology 3707:16882970 3638:Virology 3623:21994804 3569:23029581 3518:28125631 3478:PLOS ONE 3459:22022449 3419:PLOS ONE 3309:24643877 3213:34834923 3162:32878245 3111:26519596 3089:Virology 3041:37561168 2992:27033547 2933:16 March 2853:research 2841:Vaccines 1603:(OHFV), 1599:(KFDV), 1595:(TBEV), 1162:Taxonomy 1107:zoonosis 1037:seabirds 776:(UTRs). 689:zoonosis 602:helicase 575:ribosome 490:nematode 402:jaundice 319:See text 312:Species 288:Family: 252:Phylum: 112:May 2023 9582:1039277 9569:9848767 5580:2764292 5508:8570593 5476:Bibcode 5455:9420202 5425:J Virol 5300:3991153 5251:6600200 5130:8309962 5107:Viruses 4966:3381582 4917:3381566 4800:4342338 4777:Bibcode 4708:Bibcode 4672:6600200 4651:J Virol 4620:4699914 4597:Bibcode 4506:9752770 4425:9420202 4395:J Virol 4332:3479393 4239:2953152 4182:4163914 4153:Bibcode 4145:Science 4074:1395379 4053:J Virol 4034:8672458 3999:9696848 3848:1143759 3796:1112138 3775:J Virol 3747:3368002 3698:1553207 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Index

Flaviviruses

verification
improve this article
adding citations to reliable sources
"Flavivirus"
news
newspapers
books
scholar
JSTOR
Learn how and when to remove this message
A TEM micrograph of the "Yellow fever virus"
TEM
micrograph
Yellow fever virus
"Zika virus" capsid model, colored by chains, PDB entry 5ire
viral envelope
PDB
5ire
Virus classification
Edit this classification
Virus
Riboviria
Orthornavirae
Kitrinoviricota
Flasuviricetes
Amarillovirales
Flaviviridae
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