29:
379:
1833:
447:, KCl, Mg, and Mn. The primary active site residue of this enzyme is Asp181, as determined by studies of how mutations affect enzyme capacity. There are several documentations of the crystalline structure of flavonol 3-O-glucosyltransferase (2C1X, 2C1Z, and 2C9Z), and, based on these renderings of the enzyme, there is only one subunit in the quaternary structure of the molecule.
371:
366:
pathway. One specific example would be this enzymes actions on pelargonidin. Flavonol 3-O-glucosyltransferase binds the glucoside to this protein, making pelargonidin 3-O-glucoside. This enzyme is also involved in the flavone glycoside pathway, and daphnetin modification in some organisms. The role
492:
Kobayashi S, Ishimaru M, Ding CK, Yakushiji H, Goto N (February 2001). "Comparison of UDP-glucose:flavonoid 3-O-glucosyltransferase (UFGT) gene sequences between white grapes (Vitis vinifera) and their sports with red skin".
308:. The flavonoids that can act as substrates within this reaction include quercetin, kaempferol, dihydrokaempferol, kaempferid, fisetin, and isorhamnetin. Flavonol 3-O-glucosyltransferase is a hexosyl group transfer enzyme.
765:"Formation of flavonol 3-O-diglycosides and flavonol 3-O-triglycosides by enzyme extracts from anthers of Tulipa cv apeldoorn - characterization and activity of 3 different O-glycosyltransferases during anther development"
978:
973:
423:
Among those, UFGT is divided into UDP-glucose: Flavonoid 3-O-glucosyltransferase (UF3GT) and UDP-glucose: Flavonoid 5-O-glucosyltransferase (UF5GT), which are responsible for the glucosylation of
1351:
1227:
278:
1018:
588:"Isolation of a UDP-glucose: Flavonoid 5-O-glucosyltransferase gene and expression analysis of anthocyanin biosynthetic genes in herbaceous peony (Paeonia lactiflora Pall.)"
463:
549:
194:
1332:
1400:
849:
213:
1509:
1479:
1154:
1149:
1514:
652:
Hiromoto, Takeshi; Honjo, Eijiro; Noda, Naonobu; Tamada, Taro; Kazuma, Kohei; Suzuki, Masahiko; Blaber, Michael; Kuroki, Ryota (2016-12-06).
636:
354:
This enzyme is involved in the biosynthesis of secondary metabolites. The primary function of this enzyme within its pathway is binding a
464:
http://brenda-enzymes.info/enzyme.php?ecno=2.4.1.91&Suchword=&reference=&organism%5B%5D=Vitis+vinifera&show_tm=0#REACTION
1858:
550:
http://brenda-enzymes.info/enzyme.php?ecno=2.4.1.91&Suchword=&reference=&organism%5B%5D=Vitis+vinifera&show_tm=0#SOURCE
842:
1552:
1395:
709:
Offen, W; Martinez-Fleites, C; Yang, M; Kiat-Lim, E; Davis, B.G; Tarling, C.A; Ford, C.M; Bowles, D.J; Davies, G.J. (2006-01-01).
654:"Structural basis for acceptor-substrate recognition of UDP-glucose: anthocyanidin 3-O-glucosyltransferase from Clitoria ternatea"
1405:
206:
1426:
1410:
157:
133:
1708:
1863:
835:
305:
945:
798:
Sutter A, Grisebach H (1973). "UDP-glucose: flavonol 3-0-glucosyltransferase from cell suspension cultures of parsley".
930:
367:
of the enzyme in these pathways is, again, to bind a glucoside to the substrate to construct a flavonol 3-O-glucoside.
1823:
1370:
311:
This enzyme is known by the systematic name UPD-glucose:flavonol 3-O-D glucosyltransferase, and it participates in
1693:
358:
onto a flavonol molecule, forming a flavonol 3-O-glucoside. It is through this mechanism that the enzyme converts
1809:
1796:
1783:
1770:
1757:
1744:
1731:
1495:
1387:
1300:
935:
875:
1703:
151:
1657:
1600:
940:
913:
866:
285:
239:
44:
138:
1605:
1430:
993:
619:
Schomburg, Professor
Dietmar; Schomburg, Dr Ida, eds. (1 January 2006). "Flavonol 3-O-glucosyltransferase".
908:
312:
263:
218:
1626:
1545:
1474:
960:
950:
126:
1698:
711:"Structure of a Flavonoid Glucosyltransferase Reveals the Basis for Plant Natural Product Modification"
61:
1342:
1169:
903:
502:
28:
1662:
1304:
1219:
1117:
890:
862:
392:
301:
297:
154:
56:
78:
1595:
1457:
1141:
879:
786:
1853:
1499:
925:
827:
815:
740:
691:
673:
632:
518:
342:
336:
330:
254:
145:
1641:
1636:
1610:
1538:
1337:
1324:
968:
918:
807:
776:
730:
722:
681:
665:
624:
599:
510:
476:
378:
1209:
1204:
114:
1688:
1672:
1585:
1356:
396:
363:
536:
90:
506:
49:
1837:
1726:
1667:
735:
686:
653:
562:
359:
324:
189:
710:
514:
169:
1847:
1631:
1590:
1361:
898:
811:
328:). This enzyme is found within a number of other plants as well—such as snapdragons (
319:. Anthocyanins produce a purple color in the plant tissues that they are present in.
164:
790:
604:
587:
1580:
316:
1804:
1739:
1575:
858:
628:
424:
289:
173:
1832:
231:
726:
677:
1778:
1752:
355:
250:
781:
764:
744:
695:
522:
819:
370:
293:
537:"BRENDA - Information on EC 2.4.1.91 - flavonol 3-O-glucosyltransferase"
242:
102:
1519:
1377:
1110:
1105:
1100:
1095:
1090:
1058:
982:
480:
121:
1791:
1561:
1315:
1085:
1080:
1075:
1070:
1065:
1053:
1048:
1043:
1038:
1033:
1028:
1023:
1011:
1006:
1001:
669:
246:
201:
97:
85:
73:
1765:
1467:
1462:
1435:
1286:
1237:
1232:
377:
369:
1281:
1276:
1271:
1266:
1261:
1256:
1249:
1244:
1199:
1194:
1189:
1184:
1179:
1174:
1164:
1159:
1131:
1126:
1121:
109:
1534:
979:
Glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase
974:
B-N-acetylglucosaminyl-glycopeptide b-1,4-galactosyltransferase
831:
475:
Dooner, H.K. & Nelson, O.E. Biochem Genet (1977) 15: 509.
623:. Vol. 32. Springer Berlin Heidelberg. pp. 21–29.
1530:
413:
uridine diphosphoglucose-flavonol 3-O-glucosyltransferase,
267:
1228:
Dolichyl-phosphate-mannose-protein mannosyltransferase
1821:
419:
UDP-glucose:flavonoid 3-O-glucosyltransferase (UFGT).
266:
1717:
1681:
1650:
1619:
1568:
1494:
1450:
1419:
1386:
1323:
1314:
1299:
1218:
1140:
992:
959:
889:
874:
212:
200:
188:
183:
163:
144:
132:
120:
108:
96:
84:
72:
67:
55:
43:
38:
21:
435:Some of the inhibitors of this enzyme include CaCl
272:
416:UDP-glucose:flavonol 3-O-glucosyltransferase, and
586:Zhao DQ, Han CX, Ge JT, Tao J (November 2012).
1401:Hypoxanthine-guanine phosphoribosyltransferase
401:UDP-glucose:flavonol 3-O-D-glucosyltransferase
322:It is an enzyme found most notably in grapes (
1546:
843:
395:, specifically the hexosyltransferases. The
8:
1510:Beta-galactoside alpha-2,6-sialyltransferase
382:The structure of pelargonidin 3-O-glucoside.
1480:Indolylacetylinositol arabinosyltransferase
1553:
1539:
1531:
1320:
1311:
886:
850:
836:
828:
180:
27:
780:
734:
685:
603:
265:
1828:
456:
1515:Monosialoganglioside sialyltransferase
1352:NAD(P):arginine ADP-ribosyltransferase
1333:NAD:diphthamide ADP-ribosyltransferase
431:Inhibitors and Structure of the Enzyme
18:
403:. Other names in common use include:
391:This enzyme belongs to the family of
280:UDP + a flavonol 3-O-beta-D-glucoside
7:
592:Electronic Journal of Biotechnology
273:{\displaystyle \rightleftharpoons }
14:
1396:Adenine phosphoribosyltransferase
362:to anthocyanins as a part of the
1831:
1406:Uracil phosphoribosyltransferase
236:flavonol 3-O-glucosyltransferase
33:Flavonol 3-O-glucosyltransferase
22:Flavonol 3-O-glucosyltransferase
1427:Purine nucleoside phosphorylase
605:10.2225/vol15-issue6-fulltext-7
1411:Amidophosphoribosyltransferase
374:The structure of pelargonidin.
1:
515:10.1016/S0168-9452(00)00425-8
427:to produce stable molecules.
306:flavonol 3-O-beta-D-glucoside
946:Ceramide glucosyltransferase
812:10.1016/0005-2744(73)90027-2
621:Springer Handbook of Enzymes
315:and causes the formation of
629:10.1007/978-3-540-49534-5_2
1880:
1859:Enzymes of known structure
1371:Poly ADP ribose polymerase
1709:Michaelis–Menten kinetics
1388:Phosphoribosyltransferase
260:UDP-glucose + a flavonol
179:
26:
1601:Diffusion-limited enzyme
941:1,3-Beta-glucan synthase
727:10.1038/sj.emboj.7600970
563:"KEGG ENZYME: 2.4.1.115"
399:of this enzyme class is
1431:Thymidine phosphorylase
1325:ADP-ribosyltransferase
800:Biochim. Biophys. Acta
782:10.1515/znc-1982-7-808
383:
375:
313:flavonoid biosynthesis
274:
1694:Eadie–Hofstee diagram
1627:Allosteric regulation
1475:Arabinosyltransferase
951:N-glycosyltransferase
381:
373:
275:
1864:Flavonols metabolism
1704:Lineweaver–Burk plot
1343:Pseudomonas exotoxin
863:glycosyltransferases
393:glycosyltransferases
264:
1118:Hyaluronan synthase
763:Wiermann R (1982).
507:2001PlnSc.160..543K
340:), and grapefruit (
288:of this enzyme are
1663:Enzyme superfamily
1596:Enzyme promiscuity
1458:Xylosyltransferase
931:Debranching enzyme
481:10.1007/BF00520194
384:
376:
296:, whereas its two
270:
1819:
1818:
1528:
1527:
1490:
1489:
1446:
1445:
1295:
1294:
926:Glycogen synthase
769:Z. Naturforsch. C
638:978-3-540-32591-8
343:Citrus x paradisi
337:Brassica oleracea
331:Antirrhinum majus
255:chemical reaction
228:
227:
224:
223:
127:metabolic pathway
1871:
1836:
1835:
1827:
1699:Hanes–Woolf plot
1642:Enzyme activator
1637:Enzyme inhibitor
1611:Enzyme catalysis
1555:
1548:
1541:
1532:
1338:Diphtheria toxin
1321:
1312:
969:Lactose synthase
936:Branching enzyme
887:
852:
845:
838:
829:
823:
794:
784:
749:
748:
738:
706:
700:
699:
689:
670:10.1002/pro.2630
649:
643:
642:
616:
610:
609:
607:
583:
577:
576:
574:
573:
559:
553:
547:
541:
540:
533:
527:
526:
489:
483:
473:
467:
461:
279:
277:
276:
271:
181:
31:
19:
16:Class of enzymes
1879:
1878:
1874:
1873:
1872:
1870:
1869:
1868:
1844:
1843:
1842:
1830:
1822:
1820:
1815:
1727:Oxidoreductases
1713:
1689:Enzyme kinetics
1677:
1673:List of enzymes
1646:
1615:
1586:Catalytic triad
1564:
1559:
1529:
1524:
1501:
1486:
1442:
1415:
1382:
1357:Pertussis toxin
1306:
1291:
1214:
1136:
988:
955:
881:
870:
856:
826:
797:
762:
758:
756:Further reading
753:
752:
721:(6): 1396–405.
708:
707:
703:
658:Protein Science
651:
650:
646:
639:
618:
617:
613:
585:
584:
580:
571:
569:
561:
560:
556:
548:
544:
535:
534:
530:
491:
490:
486:
474:
470:
462:
458:
453:
446:
442:
438:
433:
397:systematic name
389:
364:phenylpropanoid
352:
262:
261:
34:
17:
12:
11:
5:
1877:
1875:
1867:
1866:
1861:
1856:
1846:
1845:
1841:
1840:
1817:
1816:
1814:
1813:
1800:
1787:
1774:
1761:
1748:
1735:
1721:
1719:
1715:
1714:
1712:
1711:
1706:
1701:
1696:
1691:
1685:
1683:
1679:
1678:
1676:
1675:
1670:
1665:
1660:
1654:
1652:
1651:Classification
1648:
1647:
1645:
1644:
1639:
1634:
1629:
1623:
1621:
1617:
1616:
1614:
1613:
1608:
1603:
1598:
1593:
1588:
1583:
1578:
1572:
1570:
1566:
1565:
1560:
1558:
1557:
1550:
1543:
1535:
1526:
1525:
1523:
1522:
1517:
1512:
1506:
1504:
1492:
1491:
1488:
1487:
1485:
1484:
1483:
1482:
1472:
1471:
1470:
1465:
1454:
1452:
1448:
1447:
1444:
1443:
1441:
1440:
1439:
1438:
1423:
1421:
1417:
1416:
1414:
1413:
1408:
1403:
1398:
1392:
1390:
1384:
1383:
1381:
1380:
1374:
1373:
1367:
1366:
1365:
1364:
1359:
1348:
1347:
1346:
1345:
1340:
1329:
1327:
1318:
1309:
1297:
1296:
1293:
1292:
1290:
1289:
1284:
1279:
1274:
1269:
1264:
1259:
1253:
1252:
1247:
1242:
1241:
1240:
1235:
1224:
1222:
1216:
1215:
1213:
1212:
1207:
1202:
1197:
1192:
1187:
1182:
1177:
1172:
1167:
1162:
1157:
1152:
1146:
1144:
1138:
1137:
1135:
1134:
1129:
1124:
1114:
1113:
1108:
1103:
1098:
1093:
1088:
1083:
1078:
1073:
1068:
1062:
1061:
1056:
1051:
1046:
1041:
1036:
1031:
1026:
1021:
1015:
1014:
1009:
1004:
998:
996:
990:
989:
987:
986:
976:
971:
965:
963:
957:
956:
954:
953:
948:
943:
938:
933:
928:
923:
922:
921:
916:
911:
906:
895:
893:
884:
872:
871:
857:
855:
854:
847:
840:
832:
825:
824:
795:
759:
757:
754:
751:
750:
701:
664:(3): 395–407.
644:
637:
611:
578:
554:
542:
528:
501:(3): 543–550.
484:
468:
455:
454:
452:
449:
444:
440:
436:
432:
429:
421:
420:
417:
414:
411:
388:
385:
360:anthocyanidins
351:
348:
325:Vitis vinifera
284:Thus, the two
282:
281:
269:
226:
225:
222:
221:
216:
210:
209:
204:
198:
197:
192:
186:
185:
177:
176:
167:
161:
160:
149:
142:
141:
136:
130:
129:
124:
118:
117:
112:
106:
105:
100:
94:
93:
88:
82:
81:
76:
70:
69:
65:
64:
59:
53:
52:
47:
41:
40:
36:
35:
32:
24:
23:
15:
13:
10:
9:
6:
4:
3:
2:
1876:
1865:
1862:
1860:
1857:
1855:
1852:
1851:
1849:
1839:
1834:
1829:
1825:
1811:
1807:
1806:
1801:
1798:
1794:
1793:
1788:
1785:
1781:
1780:
1775:
1772:
1768:
1767:
1762:
1759:
1755:
1754:
1749:
1746:
1742:
1741:
1736:
1733:
1729:
1728:
1723:
1722:
1720:
1716:
1710:
1707:
1705:
1702:
1700:
1697:
1695:
1692:
1690:
1687:
1686:
1684:
1680:
1674:
1671:
1669:
1668:Enzyme family
1666:
1664:
1661:
1659:
1656:
1655:
1653:
1649:
1643:
1640:
1638:
1635:
1633:
1632:Cooperativity
1630:
1628:
1625:
1624:
1622:
1618:
1612:
1609:
1607:
1604:
1602:
1599:
1597:
1594:
1592:
1591:Oxyanion hole
1589:
1587:
1584:
1582:
1579:
1577:
1574:
1573:
1571:
1567:
1563:
1556:
1551:
1549:
1544:
1542:
1537:
1536:
1533:
1521:
1518:
1516:
1513:
1511:
1508:
1507:
1505:
1503:
1497:
1493:
1481:
1478:
1477:
1476:
1473:
1469:
1466:
1464:
1461:
1460:
1459:
1456:
1455:
1453:
1449:
1437:
1434:
1433:
1432:
1428:
1425:
1424:
1422:
1418:
1412:
1409:
1407:
1404:
1402:
1399:
1397:
1394:
1393:
1391:
1389:
1385:
1379:
1376:
1375:
1372:
1369:
1368:
1363:
1362:Cholera toxin
1360:
1358:
1355:
1354:
1353:
1350:
1349:
1344:
1341:
1339:
1336:
1335:
1334:
1331:
1330:
1328:
1326:
1322:
1319:
1317:
1313:
1310:
1308:
1302:
1298:
1288:
1285:
1283:
1280:
1278:
1275:
1273:
1270:
1268:
1265:
1263:
1260:
1258:
1255:
1254:
1251:
1248:
1246:
1243:
1239:
1236:
1234:
1231:
1230:
1229:
1226:
1225:
1223:
1221:
1217:
1211:
1208:
1206:
1203:
1201:
1198:
1196:
1193:
1191:
1188:
1186:
1183:
1181:
1178:
1176:
1173:
1171:
1168:
1166:
1163:
1161:
1158:
1156:
1153:
1151:
1148:
1147:
1145:
1143:
1139:
1133:
1130:
1128:
1125:
1123:
1119:
1116:
1115:
1112:
1109:
1107:
1104:
1102:
1099:
1097:
1094:
1092:
1089:
1087:
1084:
1082:
1079:
1077:
1074:
1072:
1069:
1067:
1064:
1063:
1060:
1057:
1055:
1052:
1050:
1047:
1045:
1042:
1040:
1037:
1035:
1032:
1030:
1027:
1025:
1022:
1020:
1017:
1016:
1013:
1010:
1008:
1005:
1003:
1000:
999:
997:
995:
994:Glucuronosyl-
991:
984:
980:
977:
975:
972:
970:
967:
966:
964:
962:
958:
952:
949:
947:
944:
942:
939:
937:
934:
932:
929:
927:
924:
920:
917:
915:
912:
910:
907:
905:
902:
901:
900:
899:Phosphorylase
897:
896:
894:
892:
888:
885:
883:
877:
873:
868:
864:
860:
853:
848:
846:
841:
839:
834:
833:
830:
821:
817:
813:
809:
806:(2): 289–95.
805:
801:
796:
792:
788:
783:
778:
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165:Gene Ontology
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103:NiceZyme view
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1805:Translocases
1802:
1789:
1776:
1763:
1750:
1740:Transferases
1737:
1724:
1581:Binding site
1502:transferases
1307:transferases
882:transferases
859:Transferases
803:
799:
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661:
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570:. Retrieved
566:
557:
545:
531:
498:
494:
487:
471:
459:
434:
425:anthocyanins
422:
408:
400:
390:
387:Nomenclature
353:
341:
335:
329:
323:
321:
317:anthocyanins
310:
283:
235:
229:
91:BRENDA entry
1576:Active site
961:Galactosyl-
775:: 587–599.
290:UDP-glucose
79:IntEnz view
62:50812-18-5
39:Identifiers
1848:Categories
1779:Isomerases
1753:Hydrolases
1620:Regulation
914:Cellobiose
572:2016-12-06
451:References
443:, Cu, CuCl
286:substrates
232:enzymology
148:structures
115:KEGG entry
1658:EC number
1305:Pentosyl-
1220:Mannosyl-
891:Glucosyl-
678:0961-8368
495:Plant Sci
356:glucoside
334:), kale (
268:⇌
251:catalyzes
68:Databases
1854:EC 2.4.1
1682:Kinetics
1606:Cofactor
1569:Activity
1142:Fucosyl-
909:Glycogen
880:Hexosyl-
791:37241803
745:16482224
696:25556637
523:11166442
350:Pathways
298:products
294:flavonol
245:) is an
243:2.4.1.91
219:proteins
207:articles
195:articles
152:RCSB PDB
50:2.4.1.91
1838:Biology
1792:Ligases
1562:Enzymes
1520:ST8SIA4
1378:Sirtuin
1111:UGT2B28
1106:UGT2B17
1101:UGT2B15
1096:UGT2B11
1091:UGT2B10
1059:UGT1A10
983:C1GALT1
820:4731963
736:1422153
687:4353365
503:Bibcode
174:QuickGO
139:profile
122:MetaCyc
57:CAS no.
1824:Portal
1766:Lyases
1500:Sialyl
1496:2.4.99
1316:Ribose
1155:POFUT2
1150:POFUT1
1086:UGT2B7
1081:UGT2B4
1076:UGT2A3
1071:UGT2A2
1066:UGT2A1
1054:UGT1A9
1049:UGT1A8
1044:UGT1A7
1039:UGT1A6
1034:UGT1A5
1029:UGT1A4
1024:UGT1A3
1019:UGT1A1
1012:B3GAT3
1007:B3GAT2
1002:B3GAT1
904:Starch
818:
789:
743:
733:
715:EMBO J
694:
684:
676:
635:
552:TISSUE
521:
439:, CoCl
247:enzyme
202:PubMed
184:Search
170:AmiGO
158:PDBsum
98:ExPASy
86:BRENDA
74:IntEnz
45:EC no.
1718:Types
1468:XYLT2
1463:XYLT1
1451:Other
1436:ECGF1
1420:Other
1301:2.4.2
1287:ALG12
1238:POMT2
1233:POMT1
1210:FUT11
1205:FUT10
876:2.4.1
787:S2CID
598:(6).
249:that
134:PRIAM
1810:list
1803:EC7
1797:list
1790:EC6
1784:list
1777:EC5
1771:list
1764:EC4
1758:list
1751:EC3
1745:list
1738:EC2
1732:list
1725:EC1
1282:ALG9
1277:ALG8
1272:ALG6
1267:ALG3
1262:ALG2
1257:ALG1
1250:DPM3
1245:DPM1
1200:FUT9
1195:FUT8
1190:FUT7
1185:FUT6
1180:FUT5
1175:FUT4
1170:FUT3
1165:FUT2
1160:FUT1
1132:HAS3
1127:HAS2
1122:HAS1
919:Myo-
869:2.4)
816:PMID
741:PMID
692:PMID
674:ISSN
633:ISBN
519:PMID
466:TYPE
304:and
300:are
292:and
253:the
234:, a
214:NCBI
155:PDBe
110:KEGG
808:doi
804:309
777:doi
731:PMC
723:doi
682:PMC
666:doi
625:doi
600:doi
511:doi
499:160
477:doi
407:GTI
346:).
302:UDP
230:In
190:PMC
146:PDB
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867:EC
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240:EC
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238:(
Text is available under the Creative Commons Attribution-ShareAlike License. Additional terms may apply.
