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placental and offspring brain gene expression. Paternal-maternal interplay and offspring development is another research main interest of
Champagne and is the impact of fathers on mothers and offspring and the epigenetic mechanisms through which this interplay occurs. In addition, she is interested in exploring ways to ameliorate the negative effects of adverse prenatal and postnatal experiences on development by investigating the epigenetic mechanisms that allow offspring to overcome or be resilient to such early life experiences.
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Tang G, Gudsnuk K, Kuo SH, Cotrina M, Rosoklija G, Sosunov A, Sonders M, Kanter E, Castagna C, Yamamoto A, Yue Z, Arancio O, Peterson BS, Champagne FA, Dwork A, Goldman J, Sulzer D (2014) Loss of mTOR-dependent macroautophagy causes autistic-like synaptic pruning deficits. Neuron 83(5):1131-43. PMID
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effects of maternal behavior and how epigenetic variation emerge in response to variation in mother-infant interactions experienced during development. She also researches prenatal programming of offspring development and the impact of prenatal exposure to stress, toxins, or nutritional variation on
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in the
Department of Psychology. She maintains her affiliation with Columbia University as an adjunct associate professor within the department of psychology. As a full professor, she teaches courses including but not limited to the developing brain, behavioral epigenetics and ethics, genetics and
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that occurs in response to environmental experiences. She is known for her work on the epigenetic transmission of maternal behavior. Frances
Champagne's research has revealed how natural variations in maternal behavior can shape the behavioral development of offspring through epigenetic changes
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in a brain region specific manner. She won the NIH Director's New
Innovator Award in 2007 and the Frank A. Beach Young Investigator Award in Behavioral Neuroendocrinology in 2009. She has been described as the "bee's knees of neuroscience". She serves on the Committee on Fostering Healthy Mental,
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Champagne F, Francis DD., Mar A, Meaney MJ (2003) Naturally-occurring variations in maternal care in the rat as a mediating influence for the effects of environment on the development of individual differences in stress reactivity. Physiology & Behavior 79:359-371. PMID 12954431
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Champagne FA, Weaver ICG, Diorio J, Szyf M, Meaney MJ (2006) Maternal care associated with methylation of the estrogen receptor alpha 1b promoter and estrogen receptor alpha expression in the medial preoptic area of female offspring. Endocrinology 147(6): 2909–2915. PMID 16513834
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Champagne F, Diorio J, Sharma S, Meaney MJ (2001) Naturally occurring variations in maternal behavior in the rat are associated with differences in estrogen-inducible central oxytocin receptors. Proceedings of the
National Academy of Sciences USA 98(22):12736-41. PMID 11606726
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Champagne FA, Curley JP, Hasen N, Swaney WT & Keverne EB (2009) Paternal influence on female behavior: The role of Peg3 in exploration, olfaction and neuroendocrine regulation of maternal behavior of female mice. Behavioral
Neuroscience 123(3):469-80. PMID 19485553
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Miller RL, Yana Z, Mahera C, Zhanga H, Gudsnuk K, McDonalde J, Champagne FA (2016) Impact of prenatal polycyclic aromatic hydrocarbon exposure on behavior, cortical gene expression, and DNA methylation of the Bdnf gene. Neuroepigenetics 5: 11–18. PMID 27088078
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in New York City in 2006. Upon tenure-review, she was promoted to
Associate Profession, a position she remained until 2017. From 2016 to 2017, Dr. Champagne also served as the Vice Chair in the Department of Psychology. In 2017, she began her current tenure at
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Additionally, she is a co-investigator continuing the
Boricua Youth Study that began at Columbia University, a longitudinal study aimed at understanding the risks and protective factors that Puerto Rican youth experience. This project is funded through the
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Champagne FA, Weaver IC, Diorio J, Sharma S, Meaney MJ (2003) Natural variations in maternal care are associated with estrogen receptor alpha expression and estrogen sensitivity in the medial preoptic area. Endocrinology 144(11):4720-4. PMID 12959970
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Jensen Peña C, Champagne FA (2015) Neonatal over-expression of estrogen receptor-α alters midbrain dopamine neuron development and reverses the effects of low maternal care in female offspring. Developmental
Neurobiology 75(10):1114-24. PMID 25044746
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Champagne FA, Chretien P, Stevenson CW, Zhang TY, Gratton A, Meaney MJ (2004) Variations in nucleus accumbens dopamine associated with individual differences in maternal behavior in the rat. Journal of
Neuroscience 24(17):4113-23. PMID 15115806
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Curley JP, Davidson S, Bateson P & Champagne FA (2009) Social enrichment during postnatal development induces transgenerational effects on emotional and reproductive behavior in mice. Frontiers in Behavioral Neuroscience 3:25 PMID 19826497
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Curley JP, Rock V, Moynihan AM, Bateson P, Keverne EB, Champagne FA (2010) Developmental shifts in the behavioral phenotypes of inbred mice: the role of postnatal and juvenile social experiences. Behavior Genetics 40(2):220-32.
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Curley JP, Jordan E, Swaney WT, Izrealit A, Kammel S & Champagne FA (2009) The meaning of weaning: Influence of the weaning period on behavioral development in mice. Developmental Neuroscience 31(4):318-31. PMID 19546569
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Champagne FA (2010) Early adversity and developmental outcomes: Interaction between genetics, epigenetics and social experiences across the lifespan. Perspectives on Psychological Science 5(5) 564– 574. PMID 26162197
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in reproductive and social behavior can be induced via variation in early (prenatal and postnatal) life experiences. She has explored the interplay between mothers and fathers in the development of offspring and
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Lastly and most recently, she served on the committee for the Parental Brain Conference in 2018, a meeting focused on the biological and behavioral perspectives in parental health during the summer of 2018.
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Wan M, Kubinyi E, Miklósi A, Champagne FA (2009) A cross-cultural comparison of reports by German Shepherd Owners in Hungary and the United States of America. Applied Animal Behaviour Science 121: 206–213.
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Champagne FA, Meaney MJ (2007) Transgenerational effects of social environment on variations in maternal care and behavioral response to novelty. Behavioral Neuroscience 121(6): 1353–63. PMID 18085888
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Champagne FA & Mashoodh R (2009) Genes in context: Gene-environment interplay and the origins of individual differences in behavior. Current Directions in Psychological Science 18(3): 127–131.
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Kundakovic M, Gudsnuk K, Herbstman JB, Tang D, Perera FP, Champagne FA (2015) DNA methylation of BDNF as a biomarker of early-life adversity. Proc Natl Acad Sci U S A 12(22):6807-13. PMID 25385582
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Champagne F, Meaney MJ (2001) Like mother, like daughter: evidence for non-genomic transmission of parental behavior and stress responsivity. Progress in Brain Research 133:287-302. PMID 11589138
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Stolzenberg D & Champagne FA (2016) Hormonal and Non-hormonal bases of maternal behavior: The role of experience and epigenetic mechanisms. Hormones & Behavior 77:204-10. PMID 26172856
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Champagne FA, Curley JP, Keverne EB, Bateson PPG (2007) Natural variations in postpartum maternal care in inbred and outbred mice. Physiology & Behavior 91(2-3):325-34. PMID 17477940
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including neural mechanisms underlying individual differences in maternal behavior and the effects of the environment on these neural circuits. Another main research interest is the
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Champagne FA, Meaney MJ (2006) Stress during gestation alters maternal care and the development of offspring in a rodent model. Biological Psychiatry 59(12):1227-35. PMID 16457784
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Fagiolini M, Jensen CL, & Champagne FA (2009) Epigenetic influences on brain development and plasticity. Current Opinion in Neurobiology 19(2): 207–212. PMID 19545993
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Champagne FA (2016) Epigenetic legacy of parental experiences: Dynamic and interactive pathways to inheritance. Dev Psychopathol 28(4pt2):1219-1228. PMID 27687718
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Champagne FA (2018) Epigenetic and Multigenerational Impact of Adversity. In Violence Against Children: Making Human Rights Real. Edited by: Lenzer G, Routledge.
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Champagne FA (2008) Epigenetic mechanisms and the transgenerational effects of maternal care. Frontiers in Neuroendocrinology 29(3): 386–397. PMID 18462782
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Tost H, Champagne FA, Meyer-Lindenberg A (2015) Environmental influence in the brain, human welfare and mental health. Nature Neuroscience 18(10):1421-31.
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Champagne FA, Curley JP (2008) Maternal regulation of estrogen receptor alpha methylation. Current Opinion in Pharmacology 8(5): 963–73. PMID 18644464
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Champagne FA (2010) Epigenetic influence of social experiences across the lifespan. Developmental Psychobiology 52(4):299-311. PMID 20175106
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Gudsnuk KM, Champagne FA (2011) Epigenetic effects of early developmental experiences. Clinics in Perinatology 38(4):703-17. PMID 22107899
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Marshall WL, Anderson D, Champagne F (1997) Self-esteem and its relationship to sexual offending. Psychology Crime & Law 3(3): 161-186.
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250:. Bisphenols, including but not limited to Bisphenol A, otherwise known as BPA have previously been shown to be endocrine disrupting.
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Champagne FA, Curley JP (2005) How social experiences influence the brain. Current Opinion in Neurobiology 15(6):704-9. PMID 16260130
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Champagne FA (2009) Nurturing Nature: Social experiences and the brain. Journal of Neuroendocrinology 21(10):867-8. PMID 19686450
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that can occur throughout development as a result of environmental conditions. Most notably, the effect of prenatal exposure to
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and University Professor of Psychology at the University of Texas at Austin known for her research in the fields of
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Fostering Healthy Mental, Emotional, and Behavioral Development in Children and Youth: A National Agenda
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may contain an excessive amount of intricate detail that may interest only a particular audience
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In her new Epigenetics, Development & Neuroscience Lab, she and her lab members explore the
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on mother and infant epigenetic and behavioral outcomes. This work is funded through the
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Emotional, and Behavioral Development Among Children and Youth in the United States.
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188:. Champagne was hired as an assistant professor in the Department of Psychology at
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University of Texas at Austin: Epigenetics, Development & Neuroscience Lab
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2009 Frank A. Beach Young Investigator Award in Behavioral Neuroendocrinology
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any relevant information, and removing excessive detail that may be against
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Champagne FA (2011) Maternal imprints and the origins of variation.
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Champagne has investigated the epigenetic mechanisms via which
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Columbia University: Department of Psychology Faculty Profile
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2012-2013 Lenfest Distinguished Faculty Award in Psychology
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National Academies of Sciences, Engineering (2019-09-11).
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598:"Frank A. Beach Award in Behavioral Neuroendocrinology"
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Professor, Psychology, University of Texas at Austin
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University of Texas at Austin: Faculty Profile Page
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National Institute on Environmental Health Sciences
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515:"Epigenetics, Development and Neuroscience Lab"
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256:National Institute on Child Health Development
713:L. Kolatorova; et al. (September 2017).
544:"Frances Champagne: Department of Psychology"
126:. Research in the Champagne lab explores the
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864:McGill University Faculty of Science alumni
172:where she studied under the mentorship of
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317:Learn how and when to remove this message
494:2007 NIH Director's New Innovator Awards
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760:childadolescentpsych.cumc.columbia.edu
210:Champagne's research has examined the
879:University of Texas at Austin faculty
859:Queen's University at Kingston alumni
700:"Courses Taught by Frances Champagne"
488:Hormones and Behavior, 2011, 60, 4-11
156:, Canada where she obtained both her
100:https://labs.la.utexas.edu/champagne/
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235:effects of early life experiences.
675:Columbia University: Champagne Lab
299:Knowledge (XXG)'s inclusion policy
152:. She attended graduate school at
90:NIH Director's New Innovator Award
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874:Canadian women neuroscientists
184:in England, where she studied
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195:University of Texas at Austin
635:. National Academies Press.
854:Columbia University faculty
366:60(1):4- 11. PMID 21376726
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734:10.33549/physiolres.933723
176:. Champagne completed her
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822:Parental Brain Conference
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869:Canadian neuroscientists
148:degree in psychology at
128:developmental plasticity
364:Hormones & Behavior
182:University of Cambridge
144:Champagne received her
72:University of Cambridge
849:Canadian psychologists
728:(Suppl 3): S305–S315.
722:Physiological Research
140:Education and teaching
116:molecular neuroscience
784:parentalbrain2018.com
266:Selected publications
178:postdoctoral research
228:individual variation
108:Frances A. Champagne
23:Frances A. Champagne
744:– via PubMed.
616:Columbia University
579:. 18 September 2018
190:Columbia University
827:2019-10-26 at the
577:commonfund.nih.gov
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476:2021-01-14 at the
42:Queen's University
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124:epigenetics
838:Categories
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765:2018-10-16
685:2016-12-06
583:2018-12-13
558:2016-12-06
524:2020-05-02
501:References
375:PMC2862468
295:relocating
244:bisphenols
220:epigenetic
168:degree in
162:Psychiatry
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825:Archived
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389:Abstract
331:Abstract
206:Research
240:changes
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718:(PDF)
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