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Frank Westheimer

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506:, who moved to the University of Chicago in 1945. Westheimer applied the principles of statistical mechanics to the structure of organic molecules, to better understand the ways in which molecules are assembled from atoms. Westheimer first consulted Mayer about applying techniques from statistical mechanics to the racemization of optically active biphenyls. All of his calculations were worked out by hand. The work became a model for studies of other elements and is considered foundational. The field of 654:, also known as the "Westheimer Report", encouraged the federal government to increase spending on fundamental research in chemistry, to achieve parity with other physical sciences. It identified biochemistry as a promising and overlooked area for medical and pharmaceutical research. The report's recommendations were implemented, and it is still considered to be "comprehensive, definitive, and forward-looking". 703:"Over a span of four decades, Westheimer repeatedly demonstrated an ability to take up a fundamental scientific problem — one that appeared either insoluble or very difficult — and to solve it in an elegant and completely definitive way... He enjoyed going on to new challenges more than exploiting the large new areas that he had opened up." 592:
this route and the importance of stereochemical rearrangements of the intermediates. Westheimer developed a set of guidelines, based on experimental observations, also known as Westheimer's rules. They have been widely used for describing and predicting the products and stereochemistry of substitution reactions involving phosphorus.
448:. Westheimer related electrostatics to their effects on the properties of organic compounds. Kirkwood and Westheimer published four classical papers developing fundamental ideas in enzymology about the theory of the electrostatic influence of substituents on the dissociation constants of organic acids. They developed a 591:
Westheimer also approached the reactions of phosphate transfer through mechanisms that involve five-coordinate intermediates. In 1968, Westheimer examined pseudorotation in phosphate ester chemistry and predicted the occurrence of pseudo-rotation of oxyphosphoranes. He showed the significance of
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As well as emphasizing the need for fundamental research, Westheimer was concerned about other political issues. He argued against wars in Vietnam and Iraq. He was aware of environmental issues, supporting measures to decrease pollution, combat global warming, increase energy conservation, and
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to explain how the enzyme alcohol dehydrogenase removed hydrogen from the alcohol molecule, enabling the body to metabolize alcohol. The researchers published two classic papers in 1953, "the first demonstration of the enzymatic discrimination between the two enantiotopic hydrogen atoms on the
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in 1986 "For his series of extraordinary, original and penetrating investigations of the mechanisms of organic and enzymic reactions, which have played an unequaled role in the advancement of our knowledge of the ways in which chemical and biochemical processes proceed."
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from 1953 to 1983. He served as chairman of the chemistry department at Harvard from 1959 to 1962. He became the Morris Loeb Professor of Chemistry at Harvard in 1960. He retired from teaching to become Professor Emeritus in 1983, and retired from research in 1988.
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Westheimer completed his Ph.D. with E.P. Kohler. Although Westheimer described Kohler's organic chemistry class as "marvelous", Kohler gave Westheimer little direction or feedback about his research, which was largely self-directed. Another of Kohler's students,
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of the active site of proteins. The identification of the "active sites" of an enzyme is difficult in cases where proteins have hydrocarbon-rich sites. In 1962, Westheimer and others demonstrated the synthesis of p-nitrophenyl diazoacetate and the subsequent
524:. Vennesland and Fisher's results were puzzling in that a specific hydrogen in the pair at C1 in ethanol appeared to be uniquely reactive in the presence of the enzyme. Westheimer joined the project and helped develop an explanation based on the idea of 380:"The notion that Conant essentially was saying, 'Well, that problem is all right, but good God, you can do better,' was very important to me. From then on, I tried to ask myself about problems, whether they were really worth the investment of time." 552:
He proposed that ATP transfers phosphate through a reactive monomeric metaphosphate species. While this did not turn out to be the literal case, many enzymic reactions do proceed through transition states that have this as a significant component.
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Wang, Yong; Kumar, Devesh; Yang, Chuanlu; Han, Keli; Shaik, Sason (July 2007). "Theoretical Study of -Demethylation of Substituted -Dimethylanilines by Cytochrome P450: The Mechanistic Significance of Kinetic Isotope Effect Profiles".
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methylene carbon atom of ethanol." The phenomenon they reported was not named enantiospecificity until much later. Westheimer designed additional experiments that proved their initial conjecture and established the isotope-based
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The Westheimer medal was established in his honor in 2002. The medal is awarded by Harvard University "for distinguished research into the field of chemistry", particularly in the areas of organic and biological chemistry.
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In 1933, Conant became president of Harvard in 1933 and ceased doing research. Nonetheless, Conant's interactions with Westheimer had a lasting effect, impressing Westheimer with the need "to do important things".
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approached Westheimer about a project she and her student Harvey Fisher were doing, involving isotopes in enzyme reactions. Vennesland had developed a project involving the fate of hydrogen atoms in
549:. He continued his interest in reaction mechanisms, isotopes and oxidation. In 1955, Westheimer published the first of many articles on the chemistry of phosphate esters and phosphorus derivatives. 283:, applying techniques from physical to organic chemistry and integrating the two fields. He explored the mechanisms of chemical and enzymatic reactions, and made fundamental theoretical advances. 464:
on dipole substituted acids, showing that they could coexist in the same physical world. Elaborations and fuller testing of their ideas have required forty years and the development of computers.
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In a 1961 article, Westheimer applied ideas from statistical mechanics to the effects of isotopic substitution on the reactivity of organic molecules. His work on the magnitude of
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reactions. He hesitated to discuss his work on the triphenyl carbinol series with physical chemists because of the secrecy requirements of the project. Other researchers such as
6788: 2387: 437:, from 1936 to 1937. He became an instructor in 1937 and a Professor in 1948. As a lecturer in chemistry he taught the university's first course in physical organic chemistry. 2768: 588:
group into a bifunctional reagent enabled it to react with the enzyme. The photolabel generated a reactive carbenoid species capable of inserting into hydrocarbon C-H bonds.
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from 1953 to 1983, becoming the Morris Loeb Professor of Chemistry in 1960, and Professor Emeritus in 1983. The Westheimer medal was established in his honor in 2002.
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structure's dependence on the kinetic isotope effect is known as the Westheimer Effect. The standard nontunnelling approach to KIEs is developed from Westheimer and
360:. When told that Conant would not take on new students, Westheimer outwaited him and was finally accepted as his last graduate student. Westheimer did some work on 7119: 1742:
Glad, Sanne Schrøder; Jensen, Frank (January 1997). "Kinetic Isotope Effects and Transition State Geometries. A Theoretical Investigation of E2 Model Systems".
7104: 601:, "Why nature chose phosphates", discusses the importance of phosphates as signaling and building blocks for living organisms. Phosphates possess a value of 636: 211: 680:
develop alternative energy sources. He advocated that science needed to be taught in new ways, to better educate nonscientists about scientific issues.
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Westheimer, F. H.; Kirkwood, J. G. (September 1938). "The Electrostatic Influence of Substituents on the Dissociation Constants of Organic Acids. II".
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Kirkwood, J. G.; Westheimer, F. H. (September 1938). "The Electrostatic Influence of Substituents on the Dissociation Constants of Organic Acids. I".
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Westheimer, F. H.; Fisher, Harvey F.; Conn, Eric E.; Vennesland, Birgit (May 1951). "The enzymatic transfer of hydrogen from alcohol to DPN".
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Agmon, Noam (1985). "Extensions of the Melander-Westheimer Postulate: Isotope Effects in Reactions with Equilibrium Values Far from Unity".
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Hursthouse, M. B.; Moss, G. P.; Sales, K. D. (1978). "Chapter 3. Theoretical chemistry: Applications of molecular mechanics calculations".
948:"The Stereochemistry and Reaction Mechanism of Dehydrogenases and Their Coenzymes, DPN (NAD) and TPN (NADP): the Work of Birgit Vennesland" 338:
Frank Henry Westheimer was born on January 15, 1912, to Henry F. Westheimer (1870–1960) and Carrie C (Burgunder) Westheimer (1887–1972) of
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In 1943, Westheimer began publishing on the mechanisms of chromic acid oxidations, publishing a "masterly review" of the area in 1949.
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Westheimer, F. H.; Mayer, Joseph E. (December 1946). "The Theory of the Racemization of Optically Active Derivatives of Diphenyl".
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Frank H. Westheimer was married in 1937 to Jeanne E. Friedman. They had two children, Ellen Westheimer and Ruth Susan Westheimer.
1326: 568:. The Melander-Westheimer postulate has successfully predicted the ways in which KIEs and transition state (TS) structures vary. 1162:
Westheimer, F. H. (1 June 1961). "The Magnitude of the Primary Kinetic Isotope Effect for Compounds of Hydrogen and Deuterium".
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Frank H. Westheimer, Transcript of an Interview Conducted by Leon Gortler at Harvard University on 4 and 5 January 1979
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Frank H. Westheimer, Transcript of an Interview Conducted by Leon Gortler at Harvard University on 4 and 5 January 1979
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Kohler, E. P.; Westheimer, F. H.; Tishler, M. (February 1936). "Hydroxy Furans. I. Beta Hydroxy Triphenylfuran".
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at Conant's suggestion. Conant also suggested that Westheimer work during the summer with Alsoph Corwin at
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Laitinen, Herbert A. (March 1966). "Editorial. The Westheimer Report: Where is Analytical Chemistry?".
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He chaired the National Academy of Sciences Committee for the Survey of Chemistry from 1964 to 1965.
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Benner, Steven; Corey, Elias J. (2018). "Frank Henry Westheimer. 15 January 1912—14 April 2007".
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Ault, Addison (September 2008). "Frank Westheimer's Early Demonstration of Enzymatic Specificity".
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to form diazoacetylchymotrypsin, which was then photolyzed. The introduction of an aliphatic
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taught there. Westheimer worked with Kirkwood on problems in organic chemistry involving
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Westheimer's first academic appointment was an independent Research Associateship at the
2149: 1609: 1554:"The Enzymatic Transfer of Hydrogen. II. The Reaction Catalyzed by Lactic Dehydrogenase" 1513:"The Enzymatic Transfer of Hydrogen. I. The Reaction Catalyzed by Alcohol Dehydrogenase" 1078: 1040: 1002: 6986: 6971: 6966: 6931: 6916: 6906: 6859: 6812: 6605: 6545: 6471: 6424: 6338: 6302: 6061: 6053: 6020: 5977: 5788: 5675: 5518: 5465: 5428: 5407: 5273: 5260: 5223: 5202: 5192: 5168: 5149: 5096: 5054: 4971: 4784: 4735: 4706: 4540: 4422: 4398: 4351: 4280: 4212: 4181: 4121: 4080: 4052: 3968: 3960: 3812: 3730: 3654: 3628: 3602: 3592: 3582: 3495: 3426: 3398: 3365: 3357: 3244: 3239: 3189: 3076: 3034: 2967: 2916: 2876: 2871: 2844: 2812: 2529: 2392: 2361: 2254: 2229: 2205: 1923: 1896: 1682: 1657: 695:
in 1988; the Repligen Award for the Chemistry of Biological Processes in 1992; and the
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for two terms, from 1973 to 1975 and 1976-1978, as well as being a Councillor of the
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In 1953, soon after completing the work on alcohol dehydrogenase, Westheimer moved to
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in 1980, the Robert A. Welch Foundation Award in 1982, the Golden Plate Award of the
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Loewus, F. A.; Ofner, P.; Fisher, H.F.; Westheimer, F. H.; Vennesland, B. (1953).
1193:"The President's National Medal of Science: Recipient Details Frank H. Westheimer" 2179:
Kamerlin, Shina C. L.; Sharma, Pankaz K.; Prasad, Ram B.; Warshel, Arieh (2013).
1658:"Biological Phosphoryl-Transfer Reactions: Understanding Mechanism and Catalysis" 456:. Their Kirkwood-Westheimer model for an ellipsoid cavity reconciles the work of 6976: 6961: 6879: 6844: 6411: 6218: 6099: 6076: 6010: 5933: 5915: 5703: 5657: 5639: 5563: 5473: 5125: 5019: 4963: 4642: 4233: 4163: 4103: 4020: 3978: 3763: 3482: 3444: 3267: 2959: 2277:
Reich, Hans J.; Hondal, Robert J. (21 March 2016). "Why Nature Chose Selenium".
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Westheimer, F. H. (December 1949). "The Mechanisms of Chromic Acid Oxidations".
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Lassila, Jonathan K.; Zalatan, Jesse G.; Herschlag, Daniel (7 July 2011).
1426:"Frank Westheimer, 95, Who Developed Model Valuable in Biochemistry, Dies" 2780: 2695:"Frank H. Westheimer, major figure in 20th century chemistry, dies at 95" 1463: 913:"Frank H. Westheimer, major figure in 20th century chemistry, dies at 95" 534: 2417: 2079:
Chemical Biology of Nucleic Acids Fundamentals and Clinical Applications
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Simoni, Robert D.; Hill, Robert L.; Vaughan, Martha (January 16, 2004).
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Erdmann, Volker A.; Markiewicz, Wojciech T.; Barciszewski, Jan (2014).
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synthesis with Corwin, Westheimer gained needed laboratory experience.
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Philosophical Transactions of the Royal Society B: Biological Sciences
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Fisher, H. F.; Conn, E. E.; Vennesland, B.; Westheimer, F. H. (1953).
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Repligen Corporation Award in Chemistry of Biological Processes
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Westheimer, FH (6 March 1987). "Why nature chose phosphates".
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Wang, Linda (23 April 2007). "Frank Westheimer dies at 95".
2082:(Aufl. 2014 ed.). Berlin: Springer Verlag. p. 43. 1480:
Perspectives on structure and mechanism in organic chemistry
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Mechanisms of enzyme catalysis, and kinetic isotope effects
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Members of the United States National Academy of Sciences
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Singh, A; Thornton, ER; Westheimer, FH (September 1962).
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in 1981, the U.S. National Medal of Science in 1986, the
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that allows them to be doubly ionized at physiological
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of enzymes. This work was essential to understanding
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Westheimer came to Harvard hoping to do research with
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Westheimer was also influenced by the development of
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Biographical Memoirs of Fellows of the Royal Society
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Harvard Graduate School of Arts and Sciences alumni
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McLafferty 2006 1948:"The photolysis of diazoacetylchymotrypsin" 1895:Smith, Ewan; Collins, Ian (February 2015). 1255:Beckman Center for the History of Chemistry 1022: 1020: 6772: 6758: 6750: 6526: 6512: 6504: 5613: 5602: 5083: 5072: 4493: 4482: 4007: 3996: 3063: 3052: 2799: 2788: 2769: 2755: 2747: 2629:, 90 minute video, for Cornell University. 1714:. Boca Raton, Fla.: Taylor & Francis. 1452:Annu. Rep. Prog. Chem., Sect. B: Org. Chem 1157: 1155: 1153: 984: 982: 516:In 1950, University of Chicago biochemist 396:, Westheimer worked with physical chemist 29: 18: 2574: 2253: 2204: 2011: 1963: 1922: 1681: 1569: 1528: 1419: 1417: 1415: 1413: 1411: 1350: 1348: 963: 860: 858: 856: 854: 852: 850: 777: 755: 753: 483:, discovering a new acidity function for 1711:Isotope effects in chemistry and biology 1703: 1701: 1301:Journal of the American Chemical Society 1102:Journal of the American Chemical Society 941: 939: 937: 935: 933: 751: 749: 747: 745: 743: 741: 739: 737: 735: 733: 664:Westheimer served on the Council of the 404:. Hammett was a founder of the field of 2778:United States National Medal of Science 2623:McLafferty, Fred W.; Abruña, Héctor D. 1591: 1589: 1358:Introduction to computational chemistry 1060: 1058: 906: 904: 902: 900: 898: 896: 894: 823: 821: 729: 683:Among Westheimer's many honors are the 2666:Cromie, William J. (October 3, 2002). 2045:Advances in physical organic chemistry 1187: 1185: 828:Cromie, William J. (October 3, 2002). 1674:10.1146/annurev-biochem-060409-092741 874:Bulletin for the History of Chemistry 674:American Academy of Arts and Sciences 657:Westheimer was a member of President 643:in 1976, and a foreign member of the 7: 7120:Foreign members of the Royal Society 1636:Division of the History of Chemistry 1327:"Chandler Medal to Frank Westheimer" 1268:Hargittai, István (September 2002). 799: 797: 795: 793: 791: 789: 7105:National Medal of Science laureates 2181:"Why nature really chose phosphate" 1952:The Journal of Biological Chemistry 1862:The Journal of Physical Chemistry B 952:The Journal of Biological Chemistry 491:were first to publish in the area. 473:National Defense Research Committee 1994:Westheimer, F.H.. (January 1968). 1389:Saxe, Robert L. (April 27, 1954). 672:(1981-1984), and Secretary of the 652:Chemistry: Opportunities and Needs 635:Westheimer became a member of the 571:Westheimer introduced the idea of 279:Westheimer did pioneering work in 14: 2713:Pearce, Jeremy (April 21, 2007). 2559:"ACS 1988 National Award Winners" 1846:Isotope Effects on Reaction Rates 1424:Pearce, Jeremy (April 21, 2007). 314:and determined the mechanisms of 2648:Gortler, Leon (5 January 1979). 2458:"NAS Award in Chemical Sciences" 1744:The Journal of Organic Chemistry 1244:Gortler, Leon (5 January 1979). 394:National Research Council Fellow 2728:Chemical & Engineering News 2693:Corey, E. J. (April 19, 2007). 2563:Chemical & Engineering News 2516:American Academy of Achievement 2185:Quarterly Reviews of Biophysics 1067:The Journal of Chemical Physics 1029:The Journal of Chemical Physics 991:The Journal of Chemical Physics 911:Corey, E. J. (April 19, 2007). 689:American Academy of Achievement 7095:20th-century American chemists 670:American Philosophical Society 641:American Philosophical Society 460:on dibasic acids with that of 133:NAS Award in Chemical Sciences 1: 6818:Sivaramakrishna Chandrasekhar 2793:Behavioral and social science 2228:Hunter, T. (13 August 2012). 2111:"Why nature chose phosphates" 2000:Accounts of Chemical Research 1965:10.1016/S0021-9258(18)60265-0 1662:Annual Review of Biochemistry 1598:Journal of Chemical Education 1571:10.1016/S0021-9258(18)66182-4 1530:10.1016/S0021-9258(18)66181-2 965:10.1016/S0021-9258(20)73581-7 306:; explored the mechanisms of 2462:National Academy of Sciences 2317:National Academy of Sciences 779:10.1016/0045-2068(92)90038-5 666:National Academy of Sciences 637:National Academy of Sciences 212:National Academy of Sciences 2601:. American Chemical Society 1804:Thompson, J. M. T. (2001). 1779:Israel Journal of Chemistry 1197:National Science Foundation 595:Westheimer's 1987 paper in 420:from 1936 to 1954, and at 272:from 1936 to 1954, and at 7161: 7140:21st-century American Jews 7135:20th-century American Jews 7110:Harvard University faculty 7100:Jewish American scientists 6850:William Alexander Gambling 5681:Subrahmanyan Chandrasekhar 2393:doi:10.1098/rsbm.2018.0009 2291:10.1021/acschembio.6b00031 1902:Future Medicinal Chemistry 1477:Carroll, Felix A. (2010). 452:electrostatic analysis of 406:physical organic chemistry 294:electrostatic analysis of 281:physical organic chemistry 202:Physical organic chemistry 6541: 5612: 5601: 5082: 5071: 4656:William Hayward Pickering 4492: 4481: 4006: 3995: 3062: 3051: 2798: 2787: 2740:10.1021/cen-v085n017.p010 2640:Science History Institute 2633:Center for Oral History. 2576:10.1021/cen-v065n035.p048 2197:10.1017/S0033583512000157 1848:. New York: Ronald Press. 865:Roberts, John D. (1996). 811:Science History Institute 804:Center for Oral History. 639:in 1954, a member of the 416:Westheimer taught at the 327:National Medal of Science 255: 190: 168:National Medal of Science 28: 7115:Dartmouth College alumni 6105:Norman Foster Ramsey Jr. 5551:S. R. Srinivasa Varadhan 3182:Burrhus Frederic Skinner 366:Johns Hopkins University 349:in 1932. He went on to 334:Early life and education 161:William H. Nichols Medal 154:Welch Award in Chemistry 71:Cambridge, Massachusetts 6732:Wilfred A. van der Donk 5416:Cathleen Synge Morawetz 3334:George Ledyard Stebbins 3255:James Augustine Shannon 2158:10.1126/science.2434996 1844:Melander, Lars (1960). 1274:Chemistry International 558:kinetic isotope effects 392:In 1935 and 1936, as a 320:kinetic isotope effects 286:Westheimer worked with 6840:Malcolm Ferguson-Smith 5873:Joseph O. Hirschfelder 5860:Kenneth Sanborn Pitzer 4816:Harry George Drickamer 4762:Hans Wolfgang Liepmann 4436:M. Frederick Hawthorne 4310:John D. Baldeschwieler 3550:Daniel E. Koshland Jr. 3232:Earl W. Sutherland Jr. 2246:10.1098/rstb.2012.0013 1791:10.1002/ijch.198500122 1355:Jensen, Frank (2008). 709: 573:photoaffinity labeling 477:Bruceton, Pennsylvania 382: 302:on the calculation of 262:Frank Henry Westheimer 7064:Frank Westheimer 6708:David W. Christianson 6464:Sylvester James Gates 5850:William Alfred Fowler 5832:Robert Rathbun Wilson 5645:Robert Burns Woodward 4457:Geraldine L. Richmond 4205:Howard E. Simmons Jr. 3488:Rosalyn Sussman Yalow 3417:Vernon B. Mountcastle 3273:Sterling B. Hendricks 3090:Marshall W. Nirenberg 3085:Theodosius Dobzhansky 2933:William Julius Wilson 2635:"Frank H. Westheimer" 2313:"Frank H. Westheimer" 1361:. Chichester: Wiley. 806:"Frank H. Westheimer" 760:Zerner, Burt (1992). 522:alcohol dehydrogenase 496:statistical mechanics 479:. He did research on 435:University of Chicago 429:University of Chicago 418:University of Chicago 270:University of Chicago 7046:G. Evelyn Hutchinson 7040:Anatole Abragam 6937:Michael J. D. Powell 6823:Pierre Deslongchamps 6624:Christopher T. Walsh 6435:Warren M. Washington 6399:Fay Ajzenberg-Selove 6308:Jeremiah P. Ostriker 6253:Martin Schwarzschild 6034:Solomon J. Buchsbaum 6026:J. Robert Schrieffer 5996:E. Margaret Burbidge 5840:Nicolaas Bloembergen 5817:Arie Jan Haagen-Smit 5696:Vladimir K. Zworykin 5448:John Griggs Thompson 5371:Martin David Kruskal 5211:Kurt Otto Friedrichs 4684:Erwin Wilhelm Müller 4638:Ralph Brazelton Peck 4593:Jack St. Clair Kilby 4520:John Robinson Pierce 4487:Engineering sciences 4418:Jacqueline K. Barton 4273:George M. Whitesides 4192:Dudley R. Herschbach 4130:Richard B. Bernstein 4099:Walter H. Stockmayer 3647:Elizabeth F. Neufeld 3578:G. Evelyn Hutchinson 3468:Stanley Norman Cohen 3455:Rita Levi-Montalcini 3291:Keith Roberts Porter 3154:Alfred H. Sturtevant 3149:Michael Heidelberger 3121:Fritz Albert Lipmann 2657:. Philadelphia, PA: 2487:The Welch Foundation 2406:Analytical Chemistry 2342:search.amphilsoc.org 2338:"APS Member History" 2279:ACS Chemical Biology 2115:The Curious Waveform 2042:Bethell, D. (1989). 1464:10.1039/OC9787500023 1253:. Philadelphia, PA: 766:Bioorganic Chemistry 504:Maria Goeppert-Mayer 442:John Gamble Kirkwood 288:John Gamble Kirkwood 268:. He taught at the 147:Arthur C. Cope Award 6582:Frank H. Westheimer 6564:Stephen J. Benkovic 6485:Shirley Ann Jackson 6404:Charles P. Slichter 6248:Marshall Rosenbluth 6240:Wallace S. Broecker 6193:Eugene M. Shoemaker 5954:Victor F. Weisskopf 5901:Herbert S. Gutowsky 5883:Edgar Bright Wilson 5724:George Kistiakowsky 5342:Stephen Cole Kleene 4853:George H. Heilmeier 4840:Mildred Dresselhaus 4731:Edward H. Heinemann 4661:Frederick E. Terman 4625:Richard T. Whitcomb 4546:Clarence L. Johnson 4507:Theodore von Kármán 4394:Stephen J. Benkovic 4373:Mostafa A. El-Sayed 4360:Marvin H. Caruthers 4315:Ralph F. Hirschmann 4255:Darleane C. Hoffman 4145:Harden M. McConnell 4086:Frank H. Westheimer 3898:Stanley B. Prusiner 3862:Robert J. Lefkowitz 3621:Howard Martin Temin 3478:Maurice R. Hilleman 3473:Joseph L. Goldstein 3412:Donald A. Henderson 3329:Earl Reece Stadtman 3314:Elizabeth C. Crosby 3278:Orville Alvin Vogel 3108:Donald D. Van Slyke 3057:Biological sciences 2672:The Harvard Gazette 2512:www.achievement.org 2436:The Harvard Crimson 2418:10.1021/ac60235a600 2240:(1602): 2513–2516. 2150:1987Sci...235.1173W 2117:. February 23, 2009 2022:10.1021/ar50003a002 1610:2008JChEd..85.1246A 1395:The Harvard Crimson 1313:10.1021/ja01293a020 1176:10.1021/cr60211a004 1144:10.1021/cr60142a002 1114:10.1021/ja01149a561 1079:1946JChPh..14..733W 1041:1938JChPh...6..513W 1003:1938JChPh...6..506K 834:The Harvard Gazette 647:of London in 1983. 508:molecular mechanics 500:Joseph Edward Mayer 402:Columbia University 358:James Bryant Conant 340:Baltimore, Maryland 304:molecular mechanics 300:Joseph Edward Mayer 228:James Bryant Conant 126:Willard Gibbs Award 52:Baltimore, Maryland 7058:Henry Stommel 7018:David Attenborough 6885:Christopher Hooley 6678:Hung-Wen (Ben) Liu 6636:Rowena G. Matthews 6618:David S. Eisenberg 6600:W. Wallace Cleland 6570:Harold A. Scheraga 6357:G. Brent Dalrymple 6175:Arthur L. Schawlow 6082:James A. Van Allen 5973:Philip W. Anderson 5929:Richard P. Feynman 5855:Linus Carl Pauling 5490:Dennis P. Sullivan 5047:John B. Goodenough 4980:Edwin N. Lightfoot 4948:Yuan-Cheng B. Fung 4929:Kenneth N. Stevens 4697:Raymond D. Mindlin 4620:Harold E. Edgerton 4465:A. Paul Alivisatos 4344:Stephen J. Lippard 4323:Ernest R. Davidson 4260:Harold S. Johnston 4094:William S. Johnson 4058:George C. Pimentel 3893:Susan L. Lindquist 3875:Francis S. Collins 3769:Victor A. McKusick 3744:Francisco J. Ayala 3726:Nancy C. Andreasen 3676:Robert A. Weinberg 3450:Har Gobind Khorana 3435:Michael E. DeBakey 3422:George Emil Palade 3394:Wendell L. Roelofs 3384:Howard L. Bachrach 3214:Barbara McClintock 3116:Edward F. Knipling 2719:The New York Times 2438:. December 4, 1965 1915:10.4155/fmc.14.152 1618:10.1021/ed085p1246 1430:The New York Times 1270:"Candid Chemistry" 547:Harvard University 541:Harvard University 489:Christopher Ingold 422:Harvard University 351:Harvard University 345:He graduated from 274:Harvard University 216:Harvard University 92:Harvard University 7072: 7071: 7023:Margaret Thatcher 6992:Charles Weissmann 6875:Richard Henderson 6747: 6746: 6720:John S. Blanchard 6696:Richard Armstrong 6606:William P. Jencks 6594:Judith P. Klinman 6588:Jeremy R. Knowles 6576:William W. Parson 6501: 6500: 6497: 6496: 6493: 6492: 6430:Esther M. Conwell 6370:Robert N. Clayton 6362:Riccardo Giacconi 6326:Raymond Davis Jr. 6214:Albert Overhauser 6157:Edwin M. McMillan 6118:Arnold O. Beckman 6095:Paul Ching-Wu Chu 6072:Paul C. Lauterbur 6049:Robert Hofstadter 6001:Maurice Goldhaber 5988:Charles H. Townes 5939:Edward M. Purcell 5906:Frederick Rossini 5760:Wolfgang Panofsky 5691:John H. Van Vleck 5607:Physical sciences 5597: 5596: 5593: 5592: 5559:Solomon W. Golomb 5519:Andrew J. Viterbi 5514:Leonard Kleinrock 5461:Calyampudi R. Rao 5429:Ronald R. Coifman 5337:George F. Carrier 5318:Donald C. Spencer 5313:Saunders Mac Lane 5248:Marshall H. Stone 5198:Shiing-Shen Chern 5105:Solomon Lefschetz 5067: 5066: 5063: 5062: 5004:David J. Wineland 4972:John M. Prausnitz 4913:C. Kumar N. Patel 4908:James L. Flanagan 4876:John Roy Whinnery 4863:H. Guyford Stever 4845:Nick Holonyak Jr. 4808:George W. Housner 4803:Willis M. Hawkins 4798:Daniel C. Drucker 4780:Robert Byron Bird 4772:Bernard M. Oliver 4679:Peter C. Goldmark 4666:Wernher von Braun 4612:George E. Mueller 4585:Nathan M. Newmark 4580:J. Presper Eckert 4559:Claude E. Shannon 4528:Charles S. Draper 4477: 4476: 4473: 4472: 4444:Judith P. Klinman 4328:Gábor A. Somorjai 4239:Isabella L. Karle 4226:George S. Hammond 4187:Gertrude B. Elion 4140:Rudolph A. Marcus 3991: 3990: 3987: 3986: 3917:Ralph L. Brinster 3836:Torsten N. Wiesel 3813:Norman E. Borlaug 3800:Solomon H. Snyder 3795:J. Michael Bishop 3754:Mario R. Capecchi 3634:Salome G. Waelsch 3565:E. Donnall Thomas 3440:Theodor O. Diener 3339:Paul Alfred Weiss 3167:Bernard B. Brodie 3103:George G. Simpson 3047: 3046: 3043: 3042: 2992:Michael I. Posner 2893:Eleanor J. Gibson 2845:George J. Stigler 2813:Neal Elgar Miller 2599:"Nakanishi Prize" 1874:10.1021/jp072347v 1868:(26): 7700–7710. 1756:10.1021/jo9618379 1368:978-0-470-01186-7 1331:University Record 1087:10.1063/1.1724095 1049:10.1063/1.1750303 1011:10.1063/1.1750302 705:Elias James Corey 631:Awards and honors 518:Birgit Vennesland 347:Dartmouth College 312:Birgit Vennesland 259: 258: 246:Roberta F. Colman 238:Doctoral students 192:Scientific career 83:Dartmouth College 7152: 6774: 6767: 6760: 6751: 6690:Ronald T. Raines 6672:Michael Marletta 6612:James A. Spudich 6558:Robert H. Abeles 6552:Thomas C. Bruice 6528: 6521: 6514: 6505: 6313:Gilbert F. White 6258:George Wetherill 6152:Allan M. Cormack 6110:Jack Steinberger 6090:D. Allan Bromley 6039:H. Richard Crane 6016:Frederick Reines 6006:Helmut Landsberg 5921:George Uhlenbeck 5822:Vladimir Haensel 5784:Allan R. Sandage 5755:Herbert C. Brown 5737:Herbert Friedman 5663:Leon M. Lederman 5635:Julian Schwinger 5614: 5603: 5572:Alexandre Chorin 5546:Richard A. Tapia 5527:David B. Mumford 5355:Alberto Calderón 5300:Joseph B. Keller 5287:Michael Freedman 5256:Herman Goldstine 5110:H. Marston Morse 5084: 5073: 5012:Rudolf E. Kálmán 4996:Robert S. Langer 4988:Jan D. Achenbach 4821:Herbert E. Grier 4572:Igor I. Sikorsky 4533:Othmar H. Ammann 4494: 4483: 4449:Jerrold Meinwald 4218:Norman Hackerman 4197:Glenn T. Seaborg 4112:William O. Baker 4040:F. Albert Cotton 4008: 3997: 3974:Mary-Claire King 3867:Bert W. O'Malley 3823:Thomas E. Starzl 3818:Phillip A. Sharp 3805:Charles Yanofsky 3787:Evelyn M. Witkin 3782:James E. Darnell 3608:Paul C. Zamecnik 3573:Mary Ellen Avery 3545:Herbert W. Boyer 3540:Baruj Benacerraf 3511:Joshua Lederberg 3501:Viktor Hamburger 3463:Michael S. Brown 3309:Robert H. Burris 3064: 3053: 3000:Mortimer Mishkin 2925:William K. Estes 2909:Roger N. Shepard 2901:Robert K. Merton 2885:George A. Miller 2832:Herbert A. Simon 2800: 2789: 2771: 2764: 2757: 2748: 2743: 2722: 2709: 2707: 2705: 2682: 2680: 2678: 2662: 2656: 2644: 2611: 2610: 2608: 2606: 2595: 2589: 2588: 2578: 2569:(35): 48. 1987. 2555: 2549: 2548: 2546: 2544: 2539:. March 12, 1986 2534: 2526: 2520: 2519: 2504: 2498: 2497: 2495: 2493: 2479: 2473: 2472: 2470: 2468: 2454: 2448: 2447: 2445: 2443: 2428: 2422: 2421: 2401: 2395: 2383: 2377: 2376: 2374: 2372: 2358: 2352: 2351: 2349: 2348: 2334: 2328: 2327: 2325: 2323: 2309: 2303: 2302: 2274: 2268: 2267: 2257: 2225: 2219: 2218: 2208: 2176: 2170: 2169: 2144:(4793): 1173–8. 2133: 2127: 2126: 2124: 2122: 2107: 2101: 2100: 2098: 2096: 2073: 2067: 2066: 2064: 2062: 2039: 2033: 2032: 2030: 2028: 2015: 1991: 1985: 1984: 1982: 1980: 1967: 1943: 1937: 1936: 1926: 1892: 1886: 1885: 1856: 1850: 1849: 1841: 1835: 1834: 1832: 1830: 1811: 1801: 1795: 1794: 1774: 1768: 1767: 1739: 1733: 1732: 1730: 1728: 1705: 1696: 1695: 1685: 1653: 1647: 1646: 1644: 1642: 1628: 1622: 1621: 1593: 1584: 1583: 1573: 1549: 1543: 1542: 1532: 1508: 1502: 1501: 1499: 1497: 1474: 1468: 1467: 1447: 1441: 1440: 1438: 1436: 1421: 1406: 1405: 1403: 1401: 1386: 1380: 1379: 1377: 1375: 1352: 1343: 1342: 1340: 1338: 1323: 1317: 1316: 1296: 1290: 1289: 1287: 1285: 1265: 1259: 1258: 1252: 1241: 1208: 1207: 1205: 1203: 1189: 1180: 1179: 1164:Chemical Reviews 1159: 1148: 1147: 1132:Chemical Reviews 1127: 1118: 1117: 1097: 1091: 1090: 1062: 1053: 1052: 1024: 1015: 1014: 986: 977: 976: 974: 972: 967: 943: 928: 927: 925: 923: 908: 889: 888: 886: 884: 871: 862: 845: 844: 842: 840: 825: 816: 815: 801: 784: 783: 781: 757: 562:Transition state 454:carboxylic acids 398:Louis P. Hammett 325:He received the 308:enzyme catalysis 296:carboxylic acids 250:Steven A. Benner 223:Doctoral advisor 186: 179: 172: 165: 158: 151: 144: 140:Rosenstiel Award 137: 130: 123: 66: 48:January 15, 1912 47: 45: 33: 23:Frank Westheimer 19: 16:American chemist 7160: 7159: 7155: 7154: 7153: 7151: 7150: 7149: 7075: 7074: 7073: 7068: 7052:Jean Leray 7027: 7006: 7002:Dudley Williams 6912:C David Marsden 6855:Ian Graham Gass 6829:William Douglas 6808:Patrick Bateson 6791: 6778: 6748: 6743: 6738:Michael H. Gelb 6666:Vern L. Schramm 6642:C. Dale Poulter 6537: 6532: 6502: 6489: 6477:Sean C. Solomon 6439: 6391:Daniel Kleppner 6383:Lonnie Thompson 6378:Ralph A. Alpher 6344:W. Jason Morgan 6331:Charles Keeling 6321:Marvin L. Cohen 6288: 6271:John N. Bahcall 6266:Don L. Anderson 6232:Peter Goldreich 6185:Steven Weinberg 6137: 6067:Walter Elsasser 6044:Herman Feshbach 5958: 5896:Samuel Goudsmit 5888:Chien-Shiung Wu 5827:Frederick Seitz 5794:John A. Wheeler 5779:Robert H. Dicke 5764: 5627:Luis W. Alvarez 5608: 5589: 5577:David Blackwell 5531: 5482:Carl R. de Boor 5453:Karen Uhlenbeck 5433: 5387:Louis Nirenberg 5322: 5295:Ralph E. Gomory 5233: 5229:Donald E. Knuth 5216:Hassler Whitney 5154: 5078: 5059: 5024: 4956:Andreas Acrivos 4933: 4921:Eli Ruckenstein 4900:Hermann A. Haus 4871:Calvin F. Quate 4858:Luna B. Leopold 4825: 4716: 4702:Robert N. Noyce 4692:Emmett N. Leith 4651:Manson Benedict 4633:Rudolf Kompfner 4597: 4551:Warren K. Lewis 4488: 4469: 4403: 4365:Peter B. Dervan 4336:John I. Brauman 4295: 4247:Norman Davidson 4174:John D. Roberts 4149: 4117:Konrad E. Bloch 4063:Richard N. Zare 4025: 4002: 3983: 3940:Sallie Chisholm 3922:Rudolf Jaenisch 3902: 3885:J. Craig Venter 3844:Rita R. Colwell 3711: 3697:David Baltimore 3588:Robert W. Kates 3560:David G. Nathan 3555:Edward B. Lewis 3525: 3521:Harland G. Wood 3516:Roger W. Sperry 3371:Glenn W. Burton 3343: 3319:Arthur Kornberg 3286:Roger Guillemin 3263:Hallowell Davis 3227:Daniel I. Arnon 3219:Albert B. Sabin 3199: 3172:Detlev W. Bronk 3144:Harry F. Harlow 3139:Kenneth S. Cole 3126:William C. Rose 3098:Francis P. Rous 3058: 3039: 3004: 2984:Gordon H. Bower 2945: 2941:Robert M. Solow 2857: 2853:Milton Friedman 2817: 2794: 2783: 2775: 2725: 2712: 2703: 2701: 2699:Harvard Gazette 2692: 2689: 2676: 2674: 2665: 2654: 2647: 2632: 2620: 2615: 2614: 2604: 2602: 2597: 2596: 2592: 2557: 2556: 2552: 2542: 2540: 2532: 2528: 2527: 2523: 2506: 2505: 2501: 2491: 2489: 2481: 2480: 2476: 2466: 2464: 2456: 2455: 2451: 2441: 2439: 2430: 2429: 2425: 2403: 2402: 2398: 2384: 2380: 2370: 2368: 2360: 2359: 2355: 2346: 2344: 2336: 2335: 2331: 2321: 2319: 2311: 2310: 2306: 2276: 2275: 2271: 2227: 2226: 2222: 2178: 2177: 2173: 2135: 2134: 2130: 2120: 2118: 2109: 2108: 2104: 2094: 2092: 2090: 2075: 2074: 2070: 2060: 2058: 2056: 2041: 2040: 2036: 2026: 2024: 2013:10.1.1.557.9702 1993: 1992: 1988: 1978: 1976: 1945: 1944: 1940: 1894: 1893: 1889: 1858: 1857: 1853: 1843: 1842: 1838: 1828: 1826: 1824: 1803: 1802: 1798: 1776: 1775: 1771: 1741: 1740: 1736: 1726: 1724: 1722: 1707: 1706: 1699: 1655: 1654: 1650: 1640: 1638: 1630: 1629: 1625: 1595: 1594: 1587: 1551: 1550: 1546: 1510: 1509: 1505: 1495: 1493: 1491: 1476: 1475: 1471: 1449: 1448: 1444: 1434: 1432: 1423: 1422: 1409: 1399: 1397: 1388: 1387: 1383: 1373: 1371: 1369: 1354: 1353: 1346: 1336: 1334: 1325: 1324: 1320: 1298: 1297: 1293: 1283: 1281: 1267: 1266: 1262: 1250: 1243: 1242: 1211: 1201: 1199: 1191: 1190: 1183: 1161: 1160: 1151: 1129: 1128: 1121: 1099: 1098: 1094: 1073:(12): 733–738. 1064: 1063: 1056: 1026: 1025: 1018: 988: 987: 980: 970: 968: 945: 944: 931: 921: 919: 917:Harvard Gazette 910: 909: 892: 882: 880: 869: 864: 863: 848: 838: 836: 827: 826: 819: 803: 802: 787: 759: 758: 731: 726: 718: 697:Nakanishi Prize 693:Priestley Medal 633: 609: 543: 526:enantiotopicity 431: 414: 336: 318:oxidations and 232:Elmer P. Kohler 214: 184: 182:Nakanishi Prize 180: 177: 175:Priestley Medal 173: 170: 166: 163: 159: 156: 152: 149: 145: 142: 138: 135: 131: 128: 124: 121: 119:Centenary Prize 90: 79:Alma mater 74: 68: 64: 55: 49: 43: 41: 24: 17: 12: 11: 5: 7158: 7156: 7148: 7147: 7142: 7137: 7132: 7127: 7122: 7117: 7112: 7107: 7102: 7097: 7092: 7087: 7077: 7076: 7070: 7069: 7067: 7066: 7060: 7054: 7048: 7042: 7035: 7033: 7029: 7028: 7026: 7025: 7020: 7014: 7012: 7008: 7007: 7005: 7004: 6999: 6994: 6989: 6987:Felix Weinberg 6984: 6979: 6974: 6972:Brian Spalding 6969: 6967:Edwin Southern 6964: 6959: 6954: 6949: 6944: 6939: 6934: 6932:Michael Pepper 6929: 6924: 6919: 6917:Donald Metcalf 6914: 6909: 6907:George Lusztig 6904: 6899: 6897:Peter Lawrence 6894: 6887: 6882: 6877: 6872: 6867: 6862: 6857: 6852: 6847: 6842: 6837: 6832: 6825: 6820: 6815: 6813:Edward Cocking 6810: 6805: 6799: 6797: 6793: 6792: 6779: 6777: 6776: 6769: 6762: 6754: 6745: 6744: 6742: 6741: 6735: 6729: 6723: 6717: 6711: 6705: 6699: 6693: 6687: 6681: 6675: 6669: 6663: 6657: 6651: 6645: 6639: 6633: 6627: 6621: 6615: 6609: 6603: 6597: 6591: 6585: 6579: 6573: 6567: 6561: 6555: 6549: 6546:Gregorio Weber 6542: 6539: 6538: 6533: 6531: 6530: 6523: 6516: 6508: 6499: 6498: 6495: 6494: 6491: 6490: 6488: 6487: 6482: 6479: 6474: 6472:Burton Richter 6469: 6466: 6461: 6456: 6451: 6447: 6445: 6441: 6440: 6438: 6437: 6432: 6427: 6425:Yakir Aharonov 6422: 6419: 6414: 6409: 6406: 6401: 6396: 6393: 6388: 6385: 6380: 6375: 6372: 6367: 6364: 6359: 6354: 6351: 6346: 6341: 6339:Richard Garwin 6336: 6333: 6328: 6323: 6318: 6315: 6310: 6305: 6303:Willis E. Lamb 6300: 6296: 6294: 6290: 6289: 6287: 6286: 6281: 6276: 6273: 6268: 6263: 6260: 6255: 6250: 6245: 6242: 6237: 6234: 6229: 6224: 6221: 6216: 6211: 6208: 6203: 6198: 6195: 6190: 6187: 6182: 6177: 6172: 6169: 6164: 6159: 6154: 6149: 6145: 6143: 6139: 6138: 6136: 6135: 6130: 6125: 6120: 6115: 6112: 6107: 6102: 6097: 6092: 6087: 6084: 6079: 6074: 6069: 6064: 6062:Philip Abelson 6059: 6056: 6054:Chen-Ning Yang 6051: 6046: 6041: 6036: 6031: 6028: 6023: 6021:Bruno B. Rossi 6018: 6013: 6008: 6003: 5998: 5993: 5990: 5985: 5980: 5978:Yoichiro Nambu 5975: 5970: 5966: 5964: 5960: 5959: 5957: 5956: 5951: 5946: 5941: 5936: 5931: 5926: 5923: 5918: 5913: 5908: 5903: 5898: 5893: 5890: 5885: 5880: 5875: 5870: 5865: 5862: 5857: 5852: 5847: 5842: 5837: 5834: 5829: 5824: 5819: 5814: 5809: 5804: 5801: 5796: 5791: 5789:John C. Slater 5786: 5781: 5776: 5772: 5770: 5766: 5765: 5763: 5762: 5757: 5752: 5749: 5744: 5739: 5734: 5729: 5726: 5721: 5716: 5711: 5706: 5701: 5698: 5693: 5688: 5683: 5678: 5676:Jacob Bjerknes 5673: 5670: 5665: 5660: 5655: 5650: 5647: 5642: 5637: 5632: 5629: 5624: 5620: 5618: 5610: 5609: 5606: 5599: 5598: 5595: 5594: 5591: 5590: 5588: 5587: 5582: 5579: 5574: 5569: 5566: 5561: 5556: 5553: 5548: 5543: 5539: 5537: 5533: 5532: 5530: 5529: 5524: 5521: 5516: 5511: 5508: 5503: 5500: 5495: 5492: 5487: 5484: 5479: 5476: 5474:James G. Glimm 5471: 5468: 5466:Elias M. Stein 5463: 5458: 5455: 5450: 5445: 5441: 5439: 5435: 5434: 5432: 5431: 5426: 5421: 5418: 5413: 5410: 5408:Shing-Tung Yau 5405: 5402: 5397: 5392: 5389: 5384: 5381: 5376: 5373: 5368: 5365: 5360: 5357: 5352: 5349: 5344: 5339: 5334: 5330: 5328: 5324: 5323: 5321: 5320: 5315: 5310: 5305: 5302: 5297: 5292: 5289: 5284: 5279: 5276: 5274:Antoni Zygmund 5271: 5266: 5263: 5261:Isadore Singer 5258: 5253: 5250: 5245: 5241: 5239: 5235: 5234: 5232: 5231: 5226: 5224:Joseph L. Doob 5221: 5218: 5213: 5208: 5205: 5203:George Dantzig 5200: 5195: 5193:John W. Backus 5190: 5187: 5182: 5179: 5174: 5171: 5169:Richard Brauer 5166: 5162: 5160: 5156: 5155: 5153: 5152: 5150:William Feller 5147: 5144: 5139: 5136: 5131: 5128: 5123: 5120: 5115: 5112: 5107: 5102: 5099: 5097:Norbert Wiener 5094: 5090: 5088: 5080: 5079: 5076: 5069: 5068: 5065: 5064: 5061: 5060: 5058: 5057: 5055:Thomas Kailath 5052: 5049: 5044: 5041: 5036: 5032: 5030: 5026: 5025: 5023: 5022: 5017: 5014: 5009: 5006: 5001: 4998: 4993: 4990: 4985: 4982: 4977: 4974: 4969: 4966: 4961: 4958: 4953: 4950: 4945: 4941: 4939: 4935: 4934: 4932: 4931: 4926: 4923: 4918: 4915: 4910: 4905: 4902: 4897: 4894: 4889: 4886: 4881: 4878: 4873: 4868: 4865: 4860: 4855: 4850: 4847: 4842: 4837: 4833: 4831: 4827: 4826: 4824: 4823: 4818: 4813: 4810: 4805: 4800: 4795: 4792: 4787: 4785:H. Bolton Seed 4782: 4777: 4774: 4769: 4764: 4759: 4756: 4751: 4746: 4741: 4738: 4736:Donald L. Katz 4733: 4728: 4724: 4722: 4718: 4717: 4715: 4714: 4709: 4707:Earl R. Parker 4704: 4699: 4694: 4689: 4686: 4681: 4676: 4671: 4668: 4663: 4658: 4653: 4648: 4645: 4640: 4635: 4630: 4627: 4622: 4617: 4614: 4609: 4605: 4603: 4599: 4598: 4596: 4595: 4590: 4587: 4582: 4577: 4574: 4569: 4564: 4561: 4556: 4553: 4548: 4543: 4541:Hugh L. Dryden 4538: 4535: 4530: 4525: 4522: 4517: 4512: 4509: 4504: 4500: 4498: 4490: 4489: 4486: 4479: 4478: 4475: 4474: 4471: 4470: 4468: 4467: 4462: 4459: 4454: 4451: 4446: 4441: 4438: 4433: 4428: 4425: 4423:Peter J. Stang 4420: 4415: 4411: 4409: 4405: 4404: 4402: 4401: 4399:Marye Anne Fox 4396: 4391: 4388: 4383: 4378: 4375: 4370: 4367: 4362: 4357: 4354: 4352:Tobin J. Marks 4349: 4346: 4341: 4338: 4333: 4330: 4325: 4320: 4317: 4312: 4307: 4303: 4301: 4297: 4296: 4294: 4293: 4288: 4283: 4281:Stuart A. Rice 4278: 4275: 4270: 4265: 4262: 4257: 4252: 4249: 4244: 4241: 4236: 4231: 4228: 4223: 4220: 4215: 4213:Donald J. Cram 4210: 4207: 4202: 4199: 4194: 4189: 4184: 4182:Ronald Breslow 4179: 4176: 4171: 4166: 4161: 4157: 4155: 4151: 4150: 4148: 4147: 4142: 4137: 4132: 4127: 4124: 4122:Elias J. Corey 4119: 4114: 4109: 4106: 4101: 4096: 4091: 4088: 4083: 4081:Carl S. Marvel 4078: 4073: 4068: 4065: 4060: 4055: 4053:Roald Hoffmann 4050: 4047: 4042: 4037: 4033: 4031: 4027: 4026: 4024: 4023: 4018: 4014: 4012: 4004: 4003: 4000: 3993: 3992: 3989: 3988: 3985: 3984: 3982: 3981: 3976: 3971: 3969:Stanley Falkow 3966: 3963: 3961:Rakesh K. Jain 3958: 3955: 3950: 3945: 3942: 3937: 3932: 3927: 3924: 3919: 3914: 3910: 3908: 3904: 3903: 3901: 3900: 3895: 3890: 3887: 3882: 3877: 3872: 3869: 3864: 3859: 3856: 3851: 3846: 3841: 3838: 3833: 3828: 3825: 3820: 3815: 3810: 3807: 3802: 3797: 3792: 3789: 3784: 3779: 3776: 3771: 3766: 3764:Gene E. Likens 3761: 3756: 3751: 3749:George F. Bass 3746: 3741: 3738: 3733: 3731:Peter H. Raven 3728: 3723: 3719: 3717: 3713: 3712: 3710: 3709: 3704: 3699: 3694: 3691: 3686: 3681: 3678: 3673: 3668: 3665: 3660: 3657: 3655:Alexander Rich 3652: 3649: 3644: 3639: 3636: 3631: 3629:Daniel Nathans 3626: 3623: 3618: 3613: 3610: 3605: 3603:Folke K. Skoog 3600: 3595: 3593:Salvador Luria 3590: 3585: 3583:Elvin A. Kabat 3580: 3575: 3570: 3567: 3562: 3557: 3552: 3547: 3542: 3537: 3533: 3531: 3527: 3526: 3524: 3523: 3518: 3513: 3508: 3503: 3498: 3496:Katherine Esau 3493: 3490: 3485: 3483:Eric R. Kandel 3480: 3475: 3470: 3465: 3460: 3457: 3452: 3447: 3442: 3437: 3432: 3429: 3427:Joan A. Steitz 3424: 3419: 3414: 3409: 3404: 3401: 3399:Berta Scharrer 3396: 3391: 3386: 3381: 3378: 3373: 3368: 3366:Seymour Benzer 3363: 3360: 3358:Philip Handler 3355: 3351: 3349: 3345: 3344: 3342: 3341: 3336: 3331: 3326: 3321: 3316: 3311: 3306: 3303: 3298: 3293: 3288: 3283: 3280: 3275: 3270: 3265: 3260: 3257: 3252: 3247: 3245:Erwin Chargaff 3242: 3240:Britton Chance 3237: 3234: 3229: 3224: 3221: 3216: 3211: 3207: 3205: 3201: 3200: 3198: 3197: 3192: 3190:Robert Huebner 3187: 3184: 3179: 3174: 3169: 3164: 3159: 3156: 3151: 3146: 3141: 3136: 3133: 3128: 3123: 3118: 3113: 3110: 3105: 3100: 3095: 3092: 3087: 3082: 3079: 3077:C. B. van Niel 3074: 3070: 3068: 3060: 3059: 3056: 3049: 3048: 3045: 3044: 3041: 3040: 3038: 3037: 3035:Albert Bandura 3032: 3029: 3027:Robert Axelrod 3024: 3021: 3016: 3012: 3010: 3006: 3005: 3003: 3002: 2997: 2994: 2989: 2986: 2981: 2978: 2973: 2970: 2968:R. Duncan Luce 2965: 2962: 2957: 2953: 2951: 2947: 2946: 2944: 2943: 2938: 2935: 2930: 2927: 2922: 2919: 2917:Paul Samuelson 2914: 2911: 2906: 2903: 2898: 2895: 2890: 2887: 2882: 2879: 2877:Patrick Suppes 2874: 2872:Leonid Hurwicz 2869: 2865: 2863: 2859: 2858: 2856: 2855: 2850: 2847: 2842: 2837: 2834: 2829: 2825: 2823: 2819: 2818: 2816: 2815: 2810: 2806: 2804: 2796: 2795: 2792: 2785: 2784: 2776: 2774: 2773: 2766: 2759: 2751: 2745: 2744: 2723: 2710: 2688: 2685: 2684: 2683: 2663: 2645: 2630: 2619: 2618:External links 2616: 2613: 2612: 2590: 2550: 2521: 2499: 2474: 2449: 2423: 2396: 2378: 2353: 2329: 2304: 2285:(4): 821–841. 2269: 2220: 2171: 2128: 2102: 2088: 2068: 2054: 2034: 1986: 1938: 1909:(2): 159–183. 1887: 1851: 1836: 1823:978-0521805391 1822: 1796: 1785:(4): 375–377. 1769: 1750:(2): 253–260. 1734: 1720: 1697: 1668:(1): 669–702. 1648: 1623: 1585: 1564:(2): 699–704. 1544: 1523:(2): 687–697. 1503: 1490:978-0470276105 1489: 1469: 1442: 1407: 1381: 1367: 1344: 1318: 1307:(2): 264–267. 1291: 1260: 1209: 1181: 1170:(3): 265–273. 1149: 1138:(3): 419–451. 1119: 1092: 1054: 1035:(9): 513–517. 1016: 997:(9): 506–512. 978: 929: 890: 846: 817: 785: 772:(4): 269–284. 728: 727: 725: 722: 717: 714: 659:Lyndon Johnson 632: 629: 607: 542: 539: 498:by physicists 446:electrostatics 430: 427: 413: 410: 335: 332: 257: 256: 253: 252: 242:Emil T. Kaiser 239: 235: 234: 225: 219: 218: 209: 205: 204: 199: 195: 194: 188: 187: 116: 112: 111: 108: 107:Known for 104: 103: 80: 76: 75: 69: 67:(aged 95) 63:April 14, 2007 61: 57: 56: 50: 39: 35: 34: 26: 25: 22: 15: 13: 10: 9: 6: 4: 3: 2: 7157: 7146: 7143: 7141: 7138: 7136: 7133: 7131: 7128: 7126: 7123: 7121: 7118: 7116: 7113: 7111: 7108: 7106: 7103: 7101: 7098: 7096: 7093: 7091: 7088: 7086: 7083: 7082: 7080: 7065: 7061: 7059: 7055: 7053: 7049: 7047: 7043: 7041: 7037: 7036: 7034: 7030: 7024: 7021: 7019: 7016: 7015: 7013: 7009: 7003: 7000: 6998: 6997:John Westcott 6995: 6993: 6990: 6988: 6985: 6983: 6980: 6978: 6975: 6973: 6970: 6968: 6965: 6963: 6960: 6958: 6957:Dennis Sciama 6955: 6953: 6952:Alan Sargeson 6950: 6948: 6945: 6943: 6942:Philip Randle 6940: 6938: 6935: 6933: 6930: 6928: 6925: 6923: 6922:Keith O'Nions 6920: 6918: 6915: 6913: 6910: 6908: 6905: 6903: 6900: 6898: 6895: 6893: 6892: 6891:Anthony James 6888: 6886: 6883: 6881: 6878: 6876: 6873: 6871: 6868: 6866: 6863: 6861: 6858: 6856: 6853: 6851: 6848: 6846: 6843: 6841: 6838: 6836: 6835:R. John Ellis 6833: 6831: 6830: 6826: 6824: 6821: 6819: 6816: 6814: 6811: 6809: 6806: 6804: 6803:Martin Aitken 6801: 6800: 6798: 6794: 6790: 6786: 6785:Royal Society 6782: 6775: 6770: 6768: 6763: 6761: 6756: 6755: 6752: 6739: 6736: 6733: 6730: 6727: 6724: 6721: 6718: 6715: 6714:John Lipscomb 6712: 6709: 6706: 6703: 6700: 6697: 6694: 6691: 6688: 6685: 6684:Frank Raushel 6682: 6679: 6676: 6673: 6670: 6667: 6664: 6661: 6660:David E. Cane 6658: 6655: 6654:JoAnne Stubbe 6652: 6649: 6648:John A. Gerlt 6646: 6643: 6640: 6637: 6634: 6631: 6630:Perry A. Frey 6628: 6625: 6622: 6619: 6616: 6613: 6610: 6607: 6604: 6601: 6598: 6595: 6592: 6589: 6586: 6583: 6580: 6577: 6574: 6571: 6568: 6565: 6562: 6559: 6556: 6553: 6550: 6547: 6544: 6543: 6540: 6536: 6529: 6524: 6522: 6517: 6515: 6510: 6509: 6506: 6486: 6483: 6480: 6478: 6475: 6473: 6470: 6467: 6465: 6462: 6460: 6457: 6455: 6452: 6449: 6448: 6446: 6442: 6436: 6433: 6431: 6428: 6426: 6423: 6420: 6418: 6417:James E. Gunn 6415: 6413: 6410: 6407: 6405: 6402: 6400: 6397: 6394: 6392: 6389: 6386: 6384: 6381: 6379: 6376: 6373: 6371: 6368: 6365: 6363: 6360: 6358: 6355: 6352: 6350: 6349:Edward Witten 6347: 6345: 6342: 6340: 6337: 6334: 6332: 6329: 6327: 6324: 6322: 6319: 6316: 6314: 6311: 6309: 6306: 6304: 6301: 6298: 6297: 6295: 6291: 6285: 6282: 6280: 6277: 6274: 6272: 6269: 6267: 6264: 6261: 6259: 6256: 6254: 6251: 6249: 6246: 6243: 6241: 6238: 6235: 6233: 6230: 6228: 6225: 6222: 6220: 6217: 6215: 6212: 6209: 6207: 6204: 6202: 6199: 6196: 6194: 6191: 6188: 6186: 6183: 6181: 6178: 6176: 6173: 6170: 6168: 6167:Roger Revelle 6165: 6163: 6160: 6158: 6155: 6153: 6150: 6147: 6146: 6144: 6140: 6134: 6133:Henry Stommel 6131: 6129: 6126: 6124: 6123:Eugene Parker 6121: 6119: 6116: 6113: 6111: 6108: 6106: 6103: 6101: 6098: 6096: 6093: 6091: 6088: 6085: 6083: 6080: 6078: 6075: 6073: 6070: 6068: 6065: 6063: 6060: 6057: 6055: 6052: 6050: 6047: 6045: 6042: 6040: 6037: 6035: 6032: 6029: 6027: 6024: 6022: 6019: 6017: 6014: 6012: 6009: 6007: 6004: 6002: 5999: 5997: 5994: 5991: 5989: 5986: 5984: 5983:Edward Teller 5981: 5979: 5976: 5974: 5971: 5968: 5967: 5965: 5961: 5955: 5952: 5950: 5949:Lyman Spitzer 5947: 5945: 5942: 5940: 5937: 5935: 5932: 5930: 5927: 5924: 5922: 5919: 5917: 5914: 5912: 5909: 5907: 5904: 5902: 5899: 5897: 5894: 5891: 5889: 5886: 5884: 5881: 5879: 5876: 5874: 5871: 5869: 5868:Hans A. Bethe 5866: 5863: 5861: 5858: 5856: 5853: 5851: 5848: 5846: 5843: 5841: 5838: 5835: 5833: 5830: 5828: 5825: 5823: 5820: 5818: 5815: 5813: 5812:Maurice Ewing 5810: 5808: 5807:Carl Djerassi 5805: 5802: 5800: 5799:Saul Winstein 5797: 5795: 5792: 5790: 5787: 5785: 5782: 5780: 5777: 5774: 5773: 5771: 5767: 5761: 5758: 5756: 5753: 5750: 5748: 5747:Eugene Wigner 5745: 5743: 5740: 5738: 5735: 5733: 5732:Paul Bartlett 5730: 5727: 5725: 5722: 5720: 5719:Louis Hammett 5717: 5715: 5714:Gregory Breit 5712: 5710: 5709:Francis Birch 5707: 5705: 5702: 5699: 5697: 5694: 5692: 5689: 5687: 5684: 5682: 5679: 5677: 5674: 5671: 5669: 5668:William Rubey 5666: 5664: 5661: 5659: 5656: 5654: 5651: 5648: 5646: 5643: 5641: 5638: 5636: 5633: 5630: 5628: 5625: 5622: 5621: 5619: 5615: 5611: 5604: 5600: 5586: 5585:Michael Artin 5583: 5580: 5578: 5575: 5573: 5570: 5567: 5565: 5562: 5560: 5557: 5554: 5552: 5549: 5547: 5544: 5541: 5540: 5538: 5534: 5528: 5525: 5522: 5520: 5517: 5515: 5512: 5509: 5507: 5504: 5501: 5499: 5498:Bradley Efron 5496: 5493: 5491: 5488: 5485: 5483: 5480: 5477: 5475: 5472: 5469: 5467: 5464: 5462: 5459: 5456: 5454: 5451: 5449: 5446: 5443: 5442: 5440: 5436: 5430: 5427: 5425: 5424:Felix Browder 5422: 5419: 5417: 5414: 5411: 5409: 5406: 5403: 5401: 5400:Stephen Smale 5398: 5396: 5393: 5390: 5388: 5385: 5382: 5380: 5377: 5374: 5372: 5369: 5366: 5364: 5361: 5358: 5356: 5353: 5350: 5348: 5347:John McCarthy 5345: 5343: 5340: 5338: 5335: 5332: 5331: 5329: 5325: 5319: 5316: 5314: 5311: 5309: 5308:Samuel Karlin 5306: 5303: 5301: 5298: 5296: 5293: 5290: 5288: 5285: 5283: 5280: 5277: 5275: 5272: 5270: 5267: 5264: 5262: 5259: 5257: 5254: 5251: 5249: 5246: 5243: 5242: 5240: 5236: 5230: 5227: 5225: 5222: 5219: 5217: 5214: 5212: 5209: 5206: 5204: 5201: 5199: 5196: 5194: 5191: 5188: 5186: 5183: 5180: 5178: 5175: 5172: 5170: 5167: 5164: 5163: 5161: 5157: 5151: 5148: 5145: 5143: 5140: 5137: 5135: 5132: 5129: 5127: 5124: 5121: 5119: 5118:Oscar Zariski 5116: 5113: 5111: 5108: 5106: 5103: 5100: 5098: 5095: 5092: 5091: 5089: 5085: 5081: 5074: 5070: 5056: 5053: 5050: 5048: 5045: 5042: 5040: 5037: 5034: 5033: 5031: 5027: 5021: 5018: 5015: 5013: 5010: 5007: 5005: 5002: 4999: 4997: 4994: 4991: 4989: 4986: 4983: 4981: 4978: 4975: 4973: 4970: 4967: 4965: 4962: 4959: 4957: 4954: 4951: 4949: 4946: 4943: 4942: 4940: 4936: 4930: 4927: 4924: 4922: 4919: 4916: 4914: 4911: 4909: 4906: 4903: 4901: 4898: 4895: 4893: 4892:Ray W. Clough 4890: 4887: 4885: 4884:Alfred Y. Cho 4882: 4879: 4877: 4874: 4872: 4869: 4866: 4864: 4861: 4859: 4856: 4854: 4851: 4848: 4846: 4843: 4841: 4838: 4835: 4834: 4832: 4828: 4822: 4819: 4817: 4814: 4811: 4809: 4806: 4804: 4801: 4799: 4796: 4793: 4791: 4788: 4786: 4783: 4781: 4778: 4775: 4773: 4770: 4768: 4765: 4763: 4760: 4757: 4755: 4754:John G. Trump 4752: 4750: 4747: 4745: 4742: 4739: 4737: 4734: 4732: 4729: 4726: 4725: 4723: 4719: 4713: 4710: 4708: 4705: 4703: 4700: 4698: 4695: 4693: 4690: 4687: 4685: 4682: 4680: 4677: 4675: 4672: 4669: 4667: 4664: 4662: 4659: 4657: 4654: 4652: 4649: 4646: 4644: 4641: 4639: 4636: 4634: 4631: 4628: 4626: 4623: 4621: 4618: 4615: 4613: 4610: 4607: 4606: 4604: 4600: 4594: 4591: 4588: 4586: 4583: 4581: 4578: 4575: 4573: 4570: 4568: 4567:Edwin H. Land 4565: 4562: 4560: 4557: 4554: 4552: 4549: 4547: 4544: 4542: 4539: 4536: 4534: 4531: 4529: 4526: 4523: 4521: 4518: 4516: 4515:Vannevar Bush 4513: 4510: 4508: 4505: 4502: 4501: 4499: 4495: 4491: 4484: 4480: 4466: 4463: 4460: 4458: 4455: 4452: 4450: 4447: 4445: 4442: 4439: 4437: 4434: 4432: 4431:Allen J. Bard 4429: 4426: 4424: 4421: 4419: 4416: 4413: 4412: 4410: 4406: 4400: 4397: 4395: 4392: 4389: 4387: 4386:JoAnne Stubbe 4384: 4382: 4381:Joanna Fowler 4379: 4376: 4374: 4371: 4368: 4366: 4363: 4361: 4358: 4355: 4353: 4350: 4347: 4345: 4342: 4339: 4337: 4334: 4331: 4329: 4326: 4324: 4321: 4318: 4316: 4313: 4311: 4308: 4305: 4304: 4302: 4298: 4292: 4291:Susan Solomon 4289: 4287: 4284: 4282: 4279: 4276: 4274: 4271: 4269: 4266: 4263: 4261: 4258: 4256: 4253: 4250: 4248: 4245: 4242: 4240: 4237: 4235: 4232: 4229: 4227: 4224: 4221: 4219: 4216: 4214: 4211: 4208: 4206: 4203: 4200: 4198: 4195: 4193: 4190: 4188: 4185: 4183: 4180: 4177: 4175: 4172: 4170: 4167: 4165: 4162: 4159: 4158: 4156: 4152: 4146: 4143: 4141: 4138: 4136: 4135:Melvin Calvin 4133: 4131: 4128: 4125: 4123: 4120: 4118: 4115: 4113: 4110: 4107: 4105: 4102: 4100: 4097: 4095: 4092: 4089: 4087: 4084: 4082: 4079: 4077: 4076:Yuan Tseh Lee 4074: 4072: 4071:Harry B. 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Neel 3248: 3246: 3243: 3241: 3238: 3235: 3233: 3230: 3228: 3225: 3222: 3220: 3217: 3215: 3212: 3209: 3208: 3206: 3202: 3196: 3193: 3191: 3188: 3185: 3183: 3180: 3178: 3175: 3173: 3170: 3168: 3165: 3163: 3162:Horace Barker 3160: 3157: 3155: 3152: 3150: 3147: 3145: 3142: 3140: 3137: 3134: 3132: 3131:Sewall Wright 3129: 3127: 3124: 3122: 3119: 3117: 3114: 3111: 3109: 3106: 3104: 3101: 3099: 3096: 3093: 3091: 3088: 3086: 3083: 3080: 3078: 3075: 3072: 3071: 3069: 3065: 3061: 3054: 3050: 3036: 3033: 3030: 3028: 3025: 3022: 3020: 3019:Anne Treisman 3017: 3014: 3013: 3011: 3007: 3001: 2998: 2995: 2993: 2990: 2987: 2985: 2982: 2979: 2977: 2976:Kenneth Arrow 2974: 2971: 2969: 2966: 2963: 2961: 2958: 2955: 2954: 2952: 2948: 2942: 2939: 2936: 2934: 2931: 2928: 2926: 2923: 2920: 2918: 2915: 2912: 2910: 2907: 2904: 2902: 2899: 2896: 2894: 2891: 2888: 2886: 2883: 2880: 2878: 2875: 2873: 2870: 2867: 2866: 2864: 2860: 2854: 2851: 2848: 2846: 2843: 2841: 2840:Anne Anastasi 2838: 2835: 2833: 2830: 2827: 2826: 2824: 2820: 2814: 2811: 2808: 2807: 2805: 2801: 2797: 2790: 2786: 2782: 2779: 2772: 2767: 2765: 2760: 2758: 2753: 2752: 2749: 2741: 2737: 2733: 2729: 2724: 2720: 2716: 2711: 2700: 2696: 2691: 2690: 2686: 2673: 2669: 2664: 2660: 2653: 2652: 2646: 2642: 2641: 2636: 2631: 2628: 2627: 2622: 2621: 2617: 2600: 2594: 2591: 2586: 2582: 2577: 2572: 2568: 2564: 2560: 2554: 2551: 2538: 2531: 2525: 2522: 2517: 2513: 2509: 2503: 2500: 2488: 2484: 2478: 2475: 2463: 2459: 2453: 2450: 2437: 2433: 2427: 2424: 2419: 2415: 2411: 2407: 2400: 2397: 2394: 2390: 2389: 2382: 2379: 2367: 2363: 2357: 2354: 2343: 2339: 2333: 2330: 2318: 2314: 2308: 2305: 2300: 2296: 2292: 2288: 2284: 2280: 2273: 2270: 2265: 2261: 2256: 2251: 2247: 2243: 2239: 2235: 2231: 2224: 2221: 2216: 2212: 2207: 2202: 2198: 2194: 2190: 2186: 2182: 2175: 2172: 2167: 2163: 2159: 2155: 2151: 2147: 2143: 2139: 2132: 2129: 2116: 2112: 2106: 2103: 2091: 2089:9783642544514 2085: 2081: 2080: 2072: 2069: 2057: 2055:9780080581644 2051: 2047: 2046: 2038: 2035: 2023: 2019: 2014: 2009: 2005: 2001: 1997: 1990: 1987: 1975: 1971: 1966: 1961: 1958:(9): 3006–8. 1957: 1953: 1949: 1942: 1939: 1934: 1930: 1925: 1920: 1916: 1912: 1908: 1904: 1903: 1898: 1891: 1888: 1883: 1879: 1875: 1871: 1867: 1863: 1855: 1852: 1847: 1840: 1837: 1825: 1819: 1815: 1810: 1809: 1800: 1797: 1792: 1788: 1784: 1780: 1773: 1770: 1765: 1761: 1757: 1753: 1749: 1745: 1738: 1735: 1723: 1721:9780824724498 1717: 1713: 1712: 1704: 1702: 1698: 1693: 1689: 1684: 1679: 1675: 1671: 1667: 1663: 1659: 1652: 1649: 1637: 1633: 1627: 1624: 1619: 1615: 1611: 1607: 1603: 1599: 1592: 1590: 1586: 1581: 1577: 1572: 1567: 1563: 1559: 1558:J. Biol. Chem 1555: 1548: 1545: 1540: 1536: 1531: 1526: 1522: 1518: 1517:J. Biol. 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Index


Baltimore, Maryland
Cambridge, Massachusetts
Dartmouth College
BA
Harvard University
MS
PhD
Centenary Prize
Willard Gibbs Award
NAS Award in Chemical Sciences
Rosenstiel Award
Arthur C. Cope Award
Welch Award in Chemistry
William H. Nichols Medal
National Medal of Science
Priestley Medal
Nakanishi Prize
Physical organic chemistry
National Academy of Sciences
Harvard University
Doctoral advisor
James Bryant Conant
Elmer P. Kohler
Emil T. Kaiser
Roberta F. Colman
Steven A. Benner
chemist
University of Chicago
Harvard University

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