343:, alluding to the lack of offspring produced by flies with the mutation. However, despite the original name and a continuing history of misleading inferences by the popular media, fruitless mutants primarily show defects in male-female courtship, though certain mutants cause male-male or female-female courtship.
299:. Alternative splicing occurs at both the 5' and 3' ends, and there are several variants (other than the male- and female-specific splicing patterns). The fruitless gene locus also controls the expression of hundreds of other genes, any subset of which may actually regulate behavior.
274:. When females produce the male-spliced gene product, they behave as males. Males that do not produce the male-specific product do not court females and are infertile. In the brain, a subset (ca. 2,000) of neurons express
203:
needed for fly sexual behaviors. The gene does not have an obvious mammalian homolog, but appears to function in sex determination in species as distant as the mosquito
619:
Ruta V, Datta SR, Vasconcelos ML, Freeland J, Looger LL, Axel R (December 2010). "A dimorphic pheromone circuit in
Drosophila from sensory input to descending output".
122:
87:
75:
213:
serves as an example of how a gene or a group of genes may regulate the development and/or function of neurons involved in innate behavior. Research on
790:
832:
817:
255:
is necessary for every step in the ritual. Some alleles prevent courting entirely, while others disrupt individual components. Notably, some
723:"Behavior and cytogenetics of fruitless in Drosophila melanogaster: different courtship defects caused by separate, closely linked lesions"
822:
672:"Genomic and functional studies of Drosophila sex hierarchy regulated gene expression in adult head and nervous system tissues"
68:
218:
842:
476:
256:
195:
function is required for proper development of several anatomical structures necessary for courtship, including
177:
47:
837:
417:"Functional conservation of the fruitless male sex-determination gene across 250 Myr of insect evolution"
628:
526:
271:
185:
336:
292:, each encoding proteins containing both a BTB (Broad complex/tramtrack/bric-a-brac) domain and a
240:
gene display altered sexual behavior. Fruitfly courtship, which involves a complex male-initiated
652:
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811:
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572:"A bidirectional circuit switch reroutes pheromone signals in male and female brains"
196:
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Gailey DA, Billeter JC, Liu JH, Bauzon F, Allendorfer JB, Goodwin SF (March 2006).
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Although many genes are known to be involved in male courtship behavior, the
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has received attention in the popular press, since it provokes discussion on
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Cachero S, Ostrovsky AD, Yu JY, Dickson BJ, Jefferis GS (September 2010).
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17:
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expression is sufficient to instruct sexually dimorphic connectivity.
248:
200:
188:
328:
270:
gene has been considered noteworthy because it exhibits sex-specific
241:
63:
368:"fruitless splicing specifies male courtship behavior in Drosophila"
320:
233:
181:
570:
Kohl J, Ostrovsky AD, Frechter S, Jefferis GS (December 2013).
477:"Mating Game of Fruit Fly Is Traced to a Single Gene"
496:"Flies reveal gene that makes girls fight like boys"
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335:came to be regarded as offensive, or at best, not
458:"Homosexuality and Biology, The Genetic Quest"
311:, an apparent pun on both the common name of
8:
184:that encodes several variants of a putative
244:, may be disrupted in many ways by mutated
670:Goldman TD, Arbeitman MN (November 2007).
130:
746:
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687:
595:
546:
432:
383:
331:attitudes towards homosexuality changed,
221:, and behaviors such as gender-specific
351:
29:
7:
777:. Society for Developmental Biology.
515:"Sexual dimorphism in the fly brain"
219:genetics of human sexual orientation
25:
721:Gailey DA, Hall JC (April 1989).
494:Sample, Ian (November 20, 2006).
366:Demir E, Dickson BJ (June 2005).
307:Early work refers to the gene as
421:Molecular Biology and Evolution
339:. Thus, the gene was re-dubbed
833:Sexual orientation and science
1:
818:Drosophila melanogaster genes
689:10.1371/journal.pgen.0030216
475:Wade N (December 13, 1996).
236:flies with mutations in the
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739:10.1093/genetics/121.4.773
588:10.1016/j.cell.2013.11.025
385:10.1016/j.cell.2005.04.027
539:10.1016/j.cub.2010.07.045
259:alleles change or remove
129:
791:Entrez Gene summary for
771:"GeneBrief - fruitless"
178:Drosophila melanogaster
48:Drosophila melanogaster
823:Molecular neuroscience
803:in The Interactive Fly
434:10.1093/molbev/msj070
843:Behavioural genetics
456:Burr C (June 1997).
272:alternative splicing
186:transcription factor
123:3R: 14.22 - 14.39 Mb
641:10.1038/nature09554
633:2010Natur.468..686R
531:2010CBio...20.1589C
337:politically correct
481:The New York Times
288:has at least four
261:sexual preference
205:Anopheles gambiae
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16:(Redirected from
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627:(7324): 686–90.
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525:(18): 1589–601.
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257:loss-of-function
199:which innervate
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582:(7): 1610–23.
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27:Fruit fly gene
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838:Mutated genes
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733:(4): 773–85.
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676:PLOS Genetics
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427:(3): 633–43.
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799:Article on
294:zinc finger
143:Swiss-model
93:NP_732349.1
81:NM_169821.1
38:Identifiers
812:Categories
347:References
325:homosexual
223:aggression
139:Structures
134:Search for
117:Chromosome
111:Other data
801:fruitless
793:fruitless
341:fruitless
323:word for
317:fruit fly
290:promoters
286:fruitless
280:fruitless
276:fruitless
268:fruitless
238:fruitless
215:fruitless
211:fruitless
193:fruitless
191:. Normal
167:fruitless
33:fruitless
18:Fruitless
727:Genetics
708:18039034
649:21124455
606:24360281
557:20832311
443:16319090
402:14663286
394:15935764
229:Function
153:InterPro
43:Organism
757:2542123
748:1203660
699:2082469
657:4412743
629:Bibcode
597:3898676
548:2957842
527:Bibcode
249:alleles
201:muscles
189:protein
175:) is a
149:Domains
100:UniProt
828:Mating
755:
745:
706:
696:
655:
647:
621:Nature
604:
594:
555:
545:
441:
400:
392:
333:fruity
329:social
315:, the
309:fruity
242:ritual
105:Q8IN81
64:Entrez
55:Symbol
653:S2CID
398:S2CID
327:. As
321:slang
297:motif
69:42226
753:PMID
704:PMID
645:PMID
602:PMID
576:Cell
553:PMID
439:PMID
390:PMID
372:Cell
303:Name
278:and
234:Male
182:gene
169:gene
164:The
743:PMC
735:doi
731:121
694:PMC
684:doi
637:doi
625:468
592:PMC
584:doi
580:155
543:PMC
535:doi
429:doi
380:doi
376:121
253:fru
246:fru
173:fru
58:fru
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