152:) and that is disturbed in many cancers. She was the first to recognize that the p53 gene encoded a transcriptional activator of other genes Her lab has made significant contributions by developing and analyzing mouse models to study the activities of mutant p53, revealing how these mutations drive tumor development and progression. She also found out how the Mdm2 and Mdm4 proteins work in the body, especially in stopping cancer and controlling p53. This research suggested that blocking Mdm2/4 could be a new way to treat cancer.
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2011 - AACR-Minorities in Cancer
Research Jane Cook Wright Memorial Lectureship, an award that recognises an outstanding scientist who has, through leadership or by example, furthered the advancement of minority investigators in cancer
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Jeffers, John R.; Pinto, Emilia M.; Rehg, Jerold E.; Clay, Michael R.; Wang, Jinling; Neale, Geoffrey; Heath, Richard J.; Lozano, Guillermina; Lalli, Enzo; Figueiredo, Bonald C.; Pappo, Alberto S. (2021-05-01).
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Lozano, Guillermina (1986). "Isolation, characterization and analysis of the gene encoding the Alpha 2 type IX collagen polypeptide". ProQuest
Dissertations Publishing. Rutgers The State University of New
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Lozano is recognised for her studies of the p53 tumour suppressor pathway, from characterising p53 as a transcriptional activator to revealing the importance of two inhibitors of p53,
919:
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to an outstanding scientist who has made significant contributions to the field of cancer and who has, through leader or by example, furthered the advancement of women in science.
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164:, the daughter of Mexican immigrants. She attended a private Catholic high school, Bishop Noll, up until her senior year, when her family moved to McAllen, Texas.
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is an
American geneticist. She is a Professor and Hubert L. Olive Stringer Distinguished Chair in Oncology in Honor of Sue Gribble Stringer at the
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https://www.mdanderson.org/newsroom/guillermina-lozano-receives-aamc-award-distinguished-research-biomedical-sciences.h00-159543690.html
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https://www.science.org/doi/10.1126/science.2144364?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmed
889:
598:"The Common Germline TP53-R337H Mutation Is Hypomorphic and Confers Incomplete Penetrance and Late Tumor Onset in a Mouse Model"
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Moyer, Sydney M.; Wasylishen, Amanda R.; Qi, Yuan; Fowlkes, Natalie; Su, Xiaoping; Lozano, Guillermina (2020-09-22).
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473:"p53 drives a transcriptional program that elicits a non-cell-autonomous response and alters cell state in vivo"
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2013 - AACR-Women in Cancer
Research Charlotte Friend Memorial Lectureship. The award is presented by the
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Isolation, characterization and analysis of the gene encoding the Alpha 2 type IX collagen polypeptide
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Isolation, characterization and analysis of the gene encoding the Alpha 2 type IX collagen polypeptide
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540:"Transcriptional Activation by Wild-Type but Not Transforming Mutants of the p53 Anti-Oncogene"
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University of Texas MD Anderson Cancer Center UTHealth
Graduate School of Biomedical Sciences
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tumour suppressor pathway, characterising the protein as a regulator of gene expression (
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826:"AACR-Minorities in Cancer Research Jane Cooke Wright Memorial Lectureship Recipients"
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to explore effects of mutations in this tumor-suppressing protein on tumorogeneis.
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804:"AACR-Women in Cancer Research Charlotte Friend Memorial Lectureship Recipients"
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Lozano completed a
Bachelor of Science in biology and mathematics, graduating
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https://www.aamc.org/about-us/aamc-awards/distinguished-research/2022-lozano
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https://oir.nih.gov/wals/2022-2023/mutant-p53-activities-mouse-tumor-models
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https://oir.nih.gov/wals/named-honorific-lectures/margaret-pittman-lecture
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2022 - The Award for
Distinguished Research in the Biomedical Sciences,
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179:) in 1979. She earned a doctor of philosophy in biochemistry from
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Lozano is
Professor and Chair of the Department of Genetics at
191:. She completed postgraduate training in molecular biology at
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680:
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Members of the United States
National Academy of Sciences
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University of
Medicine and Dentistry of New Jersey alumni
360:"Her discovery expanded our knowledge of cancer genetics"
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University of Texas MD Anderson Cancer Center faculty
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Academy of Medicine, Engineering and Science of Texas
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51:Distinguished Research in the Biomedical Sciences,
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222:. Her lab has generated dozens of mouse models of
185:University of Medicine and Dentistry of New Jersey
731:American Association for Cancer Research (AACR)
477:Proceedings of the National Academy of Sciences
263:Association of American Medical Colleges (AAMC)
60:American Association for Cancer Research (AACR)
53:Association of American Medical Colleges (AAMC)
144:. Lozano is recognised for her studies of the
920:Hispanic and Latino American women scientists
205:University of Texas MD Anderson Cancer Center
134:University of Texas MD Anderson Cancer Center
102:University of Texas MD Anderson Cancer Center
8:
900:Members of the National Academy of Medicine
187:in 1986. Lozano's dissertation was titled
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538:Raycroft, L.; Wu, H.; Lozano, G. (1990).
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837:American Association for Cancer Research
815:American Association for Cancer Research
301:American Association for Cancer Research
269:American Association for Cancer Research
915:Hispanic and Latino American scientists
885:University of Texas–Pan American alumni
755:American Academy of Arts & Sciences
317:
255:2022 - Margaret Pittman Lecture Award,
865:21st-century American women scientists
860:20th-century American women scientists
429:
418:
789:"Guillermina Lozano Member Directory"
282:The American Society for Cell Biology
276:American Academy of Arts and Sciences
177:University of Texas Rio Grande Valley
67:American Academy of Arts and Sciences
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257:National Institutes of Health (NIH)
293:2014 - Elected as a member of the
287:2017 - Elected as a member of the
274:2020 - Elected as a member of the
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778:American Society for Cell Biology
267:2021 - Elected to Fellows of the
910:21st-century American biologists
727:"Guillermina (Gigi) Lozano, PhD"
280:2018 - E.E Just Lecture Award,
1:
614:10.1158/0008-5472.CAN-20-1750
207:. She is also a professor at
793:National Academy of Sciences
685:National Academy of Medicine
295:National Academy of Medicine
289:National Academy of Sciences
240:National Academy of Medicine
236:National Academy of Sciences
81:National Academy of Medicine
74:National Academy of Sciences
448:"Guillermina (Gigi) Lozano"
391:"Guillermina (Gigi) Lozano"
936:
875:American women geneticists
234:Lozano is a member of the
890:Rutgers University alumni
452:MD Anderson Cancer Center
395:MD Anderson Cancer Center
364:MD Anderson Cancer Center
130:Guillermina 'Gigi' Lozano
123:
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156:Early life and education
564:10.1126/science.2144364
498:10.1073/pnas.2008474117
173:Pan American University
33:Pan American University
428:Cite journal requires
162:East Chicago, Indiana
870:American geneticists
751:"Guillermina Lozano"
657:"Guillermina Lozano"
193:Princeton University
150:transcription factor
774:"E.E. Just Lecture"
556:1990Sci...249.1049R
550:(4972): 1049–1051.
489:2020PNAS..11723663M
483:(38): 23663–23673.
199:Career and research
195:from 1985 to 1987.
160:Lozano was born in
16:American geneticist
831:2019-03-08 at the
809:2019-03-08 at the
230:Awards and honours
181:Rutgers University
38:Rutgers University
23:Guillermina Lozano
661:www.nasonline.org
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736:2022-02-11
690:2022-02-11
666:2022-02-11
457:2022-02-11
400:2018-12-10
369:2023-02-21
312:References
622:0008-5472
507:0027-8424
307:research.
829:Archived
807:Archived
681:"Member"
640:33637564
525:32900967
83:, (2014)
79:Member,
72:Member,
65:Member,
58:Fellow,
631:8137600
582:2144364
573:2935288
552:Bibcode
544:Science
516:7519296
485:Bibcode
415:Jersey.
250:Awards:
138:Houston
638:
628:
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271:(AACR)
118:(1986)
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109:Thesis
76:(2017)
69:(2020)
62:(2021)
55:(2022)
45:Awards
175:(now
171:, at
142:Texas
40:(PhD)
35:(BSc)
636:PMID
618:ISSN
578:PMID
521:PMID
503:ISSN
434:help
220:Mdm4
218:and
216:Mdm2
183:and
626:PMC
610:doi
568:PMC
560:doi
548:249
511:PMC
493:doi
481:117
224:p53
146:p53
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Text is available under the Creative Commons Attribution-ShareAlike License. Additional terms may apply.