116:
141:
1027:
1190:, excitatory receptors. In GABA receptors, alcohol substrates bind allosterically, which allows the GABA receptors to increase their inhibitory activity. Besides giving GABA receptors an extra inhibitory punch, alcohol substrates bind to glutamate receptors, which blocks its excitatory activity. Alcohol effects on both of these metabolic pathways obstruct the brain from making memories, making well thought out decisions, and controlling impulses after long term use.
356:
349:
1176:
1104:
147:
1147:. Some examples of behavioral disorders include anxiety, alcohol dependence, and drug use. GABRA2 is a binding site for benzodiazepines. Benzodiazepines are psychoactive drugs known to reduce anxiety. Benzodiazepines bind to GABRA2 causing chloride channels to open, leading to the hyper-polarization of the membrane. Other anxiolytic drugs like
1035:
1219:. In animals, such as rats, a relationship was found between elevated alcohol consumption and increased impulsivity to those exposed to stress at an early stage in life. This impulsivity can be reversed with pharmacological handling of GABA-A receptors containing GABRA2 in certain neurological areas.
1210:
The
International Behavioural and Neural Genetics Society reviewed studies that found a linkage between β1-subunits in GABA-A receptors and excitability in the reward sensitivity behavior brain region. The linkage between these two suggests that inadequate GABRA2 variants can cause the development of
1111:
GABRA2 is one of the 16 distinct alpha subunits found for the GABA receptor. GABA-A has a pentametric form, with two alpha, two beta, and one gamma subunit. The various subunit isoforms seen in the GABA-A receptor structure have an effect on its function. GABRA2 is most often seen as part of the most
2062:
Hadingham KL, Wingrove P, Le
Bourdelles B, Palmer KJ, Ragan CI, Whiting PJ (June 1993). "Cloning of cDNA sequences encoding human alpha 2 and alpha 3 gamma-aminobutyric acidA receptor subunits and characterization of the benzodiazepine pharmacology of recombinant alpha 1-, alpha 2-, alpha 3-, and
1197:
genotyping, and measurement of genetic variation, found GABRA2's association with alcoholism within
European and African ancestries. Most of these findings were strongly associated with early alcohol use and along with drug dependence. Besides these findings, COGA investigators identified GABRA2
1214:
GABRA2 genes have been linked to various behavioral traits, such as an absence of impulse control. At least 11 single nucleotide polymorphisms, or SNPs, within the GARBRA2 gene have been correlated to impulsivity and four of which were also found in alcoholism. There was an elevated neuronal
1094:
Subunit isoforms are seen around in various locations in the brain throughout growth. The combination of subunits has a large effect on the pharmacological and biophysical characteristics. GABRA2 has been found to mediate anxiolytic activity, which plays a key role in emotional and behavioral
1840:
Dick DM, Bierut L, Hinrichs A, Fox L, Bucholz KK, Kramer J, Kuperman S, Hesselbrock V, Schuckit M, Almasy L, Tischfield J, Porjesz B, Begleiter H, Nurnberger J, Xuei X, Edenberg HJ, Foroud T (July 2006). "The role of GABRA2 in risk for conduct disorder and alcohol and drug dependence across
1802:
Agrawal A, Edenberg HJ, Foroud T, Bierut LJ, Dunne G, Hinrichs AL, Nurnberger JI, Crowe R, Kuperman S, Schuckit MA, Begleiter H, Porjesz B, Dick DM (September 2006). "Association of GABRA2 with drug dependence in the collaborative study of the genetics of alcoholism sample".
1090:
GABA-A receptors are composed of two alpha, two beta, and one gamma subunits. They have at least 16 distinct subunits identified, including GABRA2. This receptor is found mainly in specific regions of the brain, such as the hippocampus.
1936:
Edenberg HJ, Dick DM, Xuei X, Tian H, Almasy L, Bauer LO, Crowe RR, Goate A, Hesselbrock V, Jones K, Kwon J, Li TK, Nurnberger JI, O'Connor SJ, Reich T, Rice J, Schuckit MA, Porjesz B, Foroud T, Begleiter H (April 2004).
1166:
Since GABRA 2 mediates anxiolytic activity, it is a key receptor for emotional control. Several developmental stages of GABRA2 have shown effects on behavior such as adult alcohol dependence and adolescent behavior.
1120:. It is more confined to areas of the brain in comparison to other alpha subunits seen in GABA-A receptors. It is present in 35% of all GABA-A receptors being the fourth most abundant subunit next to
1124:
and various beta subunits. Like all subunits, it is made from structurally distinct proteins. The presence of this subunit causes an easier binding of benzodiazepine which is a category of
1038:
GABAA receptor animation demonstrates the various subunit types that make up the GABA receptor. All the variants of GABA (A) receptors have different functions within the mammalian brain.
1211:
mental disorders, such as addiction. The addictive behaviors can be seen as aggressive and defiant, but most of these behaviors can be caused by both genetic and environmental factors.
4415:
1136:
GABRA2 mediates neural activity necessary for information processing in inter-neurons. GABRA2 participates in transporting Cl ions into the membrane, since it forms part of the
2171:
4209:
2931:
1158:. The insula is part of the cerebral cortex responsible for emotions. GABRA2 role in reward behavior explains the higher risk of alcohol dependence and drug use behavior.
154:
4818:
3861:
3821:
2269:
1121:
2086:"gamma-Aminobutyric acidA receptors displaying association of gamma 3-subunits with beta 2/3 and different alpha-subunits exhibit unique pharmacological properties"
1980:
Bonnert TP, McKernan RM, Farrar S, le
Bourdellès B, Heavens RP, Smith DW, Hewson L, Rigby MR, Sirinathsinghji DJ, Brown N, Wafford KA, Whiting PJ (August 1999).
4807:
2139:
699:
77:
1718:"The role of the GABRA2 polymorphism in multiplex alcohol dependence families with minimal comorbidity: within-family association and linkage analyses"
680:
1183:
Since GABRA 2 subunit mediates anxiolytic activity, long term use or withdrawal of ethanol can cause dependence alterations in the GABA-A receptor.
3871:
2164:
1939:"Variations in GABRA2, encoding the alpha 2 subunit of the GABA(A) receptor, are associated with alcohol dependence and with brain oscillations"
1761:"Linkage disequilibrium, haplotype and association studies of a chromosome 4 GABA receptor gene cluster: candidate gene variants for addictions"
2924:
4179:
1361:
1291:
1107:
Shows the five subunits that comprise the GABA-A receptor. GABRA2 is only one alpha subunit in the structure demonstrated with the color red.
3690:
1273:
4840:
4244:
3695:
4317:
4267:
3182:
2157:
1144:
4428:
3207:
969:
4420:
4297:
2917:
2580:
2568:
4505:
2963:
4347:
4322:
2600:
2477:
1327:
1260:
4390:
4149:
3851:
2613:
4327:
140:
115:
4477:
4332:
1309:
1256:
4800:
1187:
1112:
common expression α2β3γ2, which is seen in 13% of all GABA-A receptors. The subunit, GABRA2, is found primarily in the
57:
4337:
4312:
3221:
4204:
3740:
3735:
3730:
1878:
Tian H, Chen HJ, Cross TH, Edenberg HJ (June 2005). "Alternative splicing and promoter use in the human GABRA2 gene".
153:
3725:
3720:
4114:
2635:
2592:
146:
1030:
GABA receptor types and their clinical functions. Notice that α2 receptor type refers to the GABRA2, an anxiolyte.
4594:
4584:
4438:
4129:
4010:
2954:
2435:
4395:
4262:
3177:
3147:
2149:
2649:
2188:
2130:
1675:"α2-containing GABA(A) receptors: a target for the development of novel treatment strategies for CNS disorders"
1434:"α2-containing GABA(A) receptors: a target for the development of novel treatment strategies for CNS disorders"
1064:
65:
4342:
4375:
4589:
4564:
4219:
3022:
725:
1193:
Collaborative Study on
Genetics of Alcoholism (COGA) identified alcohol dependence on chromosome 4p, where
1186:
When alcohol is present in the brain, it affects two types of receptors: GABA-A, inhibitory receptors, and
3985:
3846:
3580:
2836:
4744:
4360:
3012:
4845:
3826:
2184:
3625:
1095:
control. Most GABRA2 modifications have been found to be linked to alcoholism and adolescent behavior.
1907:
Chou KC (April 2004). "Modelling extracellular domains of GABA-A receptors: subtypes 1, 2, 3, and 5".
4549:
4214:
4069:
3705:
3216:
3017:
1993:
129:
3555:
44:
4599:
4579:
4074:
4063:
3700:
3404:
3226:
3117:
2849:
2126:
931:
927:
923:
919:
915:
911:
907:
903:
899:
895:
891:
881:
877:
873:
869:
824:
820:
816:
1026:
4779:
3788:
3460:
3422:
3077:
3067:
2946:
2652:
2387:
2196:
1866:
1828:
1140:. The influx of Cl causes the hyper-polarization of the membrane, leading to inhibitory actions.
89:
3881:
3645:
952:
865:
845:
812:
438:
transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential
4739:
4734:
4729:
4724:
4719:
4684:
4355:
4099:
4709:
4694:
4569:
4410:
4405:
4380:
4139:
4041:
3975:
3670:
3432:
3279:
3234:
3072:
3057:
3052:
3027:
2107:
2072:
2050:
2021:
1968:
1924:
1895:
1858:
1820:
1790:
1747:
1704:
1650:
1604:
1555:
1514:
1463:
1411:
1357:
1310:"GABRA2 gamma-aminobutyric acid type A receptor alpha2 subunit [Homo sapiens (human)]"
1216:
1125:
37:
3891:
3650:
4699:
4534:
4287:
3945:
3745:
3675:
3510:
3408:
3240:
3121:
2694:
2427:
2097:
2042:
2011:
2001:
1958:
1950:
1916:
1887:
1850:
1812:
1780:
1772:
1737:
1729:
1694:
1686:
1640:
1594:
1586:
1545:
1504:
1494:
1453:
1445:
1401:
1393:
1068:
355:
348:
233:
164:
85:
1175:
1103:
4046:
3955:
3920:
3588:
3570:
3495:
3452:
3315:
2033:
Russek SJ (February 1999). "Evolution of GABA(A) receptor diversity in the human genome".
208:
1997:
1179:
This is a representation of alcohol's effects on GABA receptors and glutamate receptors.
4629:
4524:
3574:
3444:
3436:
3339:
3265:
3230:
2261:
2213:
1963:
1938:
1785:
1760:
1742:
1717:
1699:
1674:
1599:
1574:
1550:
1533:
1509:
1482:
1458:
1433:
1406:
1381:
1228:
1194:
1155:
1137:
1080:
1060:
2102:
2085:
2046:
1891:
614:
609:
604:
599:
594:
589:
584:
579:
574:
569:
564:
559:
554:
549:
533:
528:
523:
518:
513:
508:
503:
498:
493:
488:
483:
478:
473:
468:
463:
458:
453:
437:
432:
427:
422:
417:
412:
407:
402:
397:
4834:
4539:
4229:
4036:
3924:
3905:
3841:
3768:
3680:
3630:
3596:
3559:
3520:
3470:
3310:
3305:
3295:
3259:
3162:
3097:
3047:
2996:
2940:
2739:
2669:
2253:
2205:
2143:
2016:
1981:
1690:
1449:
1198:
associated with impulsiveness and found other phenotypes affected by alcohol such as
384:
1870:
4496:
4467:
4461:
4272:
4059:
4022:
4018:
3940:
3836:
3524:
3499:
3475:
3197:
3002:
2857:
1832:
226:
106:
69:
93:
4749:
4674:
4609:
4448:
4385:
4292:
4234:
4144:
4014:
4005:
3965:
3760:
3620:
3615:
3604:
3600:
3550:
3540:
3427:
3412:
3394:
3289:
3255:
3112:
3062:
3042:
2992:
2180:
1296:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1278:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1113:
1986:
Proceedings of the
National Academy of Sciences of the United States of America
1920:
4634:
4544:
4453:
4443:
4302:
4119:
4109:
4094:
4089:
4084:
4051:
4030:
4000:
3935:
3915:
3909:
3811:
3778:
3772:
3764:
3665:
3660:
3655:
3640:
3592:
3565:
3530:
3505:
3364:
3359:
3353:
3300:
3249:
3245:
3132:
2987:
1854:
1816:
1733:
1397:
123:
73:
1590:
4769:
4764:
4754:
4714:
4659:
4644:
4624:
4619:
4604:
4400:
4370:
4277:
4257:
4252:
4104:
4026:
3960:
3930:
3901:
3831:
3816:
3783:
3750:
3514:
3490:
3448:
3440:
3399:
3389:
3373:
3369:
3345:
3330:
3325:
3285:
3202:
3187:
3152:
3142:
3127:
3102:
3082:
3037:
2006:
1199:
1117:
644:
326:
247:
192:
179:
81:
2909:
2054:
2025:
1972:
1928:
1899:
1862:
1824:
1794:
1751:
1708:
1654:
1608:
1559:
1518:
1483:"Anxiety disorders and GABA neurotransmission: a disturbance of modulation"
1467:
1415:
1034:
2111:
2076:
1014:
1009:
4759:
4689:
4679:
4639:
4614:
4554:
4457:
4365:
4239:
4169:
4124:
4055:
3995:
3980:
3895:
3856:
3755:
3635:
3544:
3484:
3464:
3456:
3349:
3335:
3319:
3269:
3167:
3157:
3137:
3107:
3091:
2982:
1776:
1148:
1076:
998:
787:
768:
1716:
Matthews AG, Hoffman EK, Zezza N, Stiffler S, Hill SY (September 2007).
1328:"Entrez Gene: GABRA2 gamma-aminobutyric acid (GABA) A receptor, alpha 2"
4664:
4649:
4559:
4472:
4199:
4159:
4154:
4079:
3990:
3970:
3886:
3715:
3710:
3535:
3275:
3191:
3172:
3007:
2784:
2779:
2528:
1765:
American
Journal of Medical Genetics. Part B, Neuropsychiatric Genetics
1499:
1046:
754:
711:
1645:
1628:
4529:
3480:
3383:
3087:
2774:
2769:
2764:
2759:
2754:
2749:
2548:
2543:
2538:
2533:
2523:
2518:
2513:
2508:
2503:
2498:
2493:
2488:
2412:
2404:
2396:
2357:
2349:
2341:
2333:
2325:
2317:
2309:
2301:
2293:
2285:
1143:
GABRA2 increases the risk of anxiety making it a target for treating
1084:
982:
666:
1627:
Stephens DN, King SL, Lambert JJ, Belelli D, Duka T (January 2017).
1954:
4574:
4224:
3950:
3800:
3416:
3032:
2892:
2887:
2882:
2877:
2872:
2867:
2862:
2817:
2809:
2744:
2719:
2714:
2709:
2704:
2699:
2688:
2683:
2678:
2673:
2558:
2553:
2459:
2451:
2443:
2380:
2375:
2370:
2365:
2241:
2236:
2231:
2226:
2221:
1174:
1151:
target this alpha subunit in GABA-A to induce inhibitory effects.
1102:
1079:
conductance of these channels can be modulated by agents, such as
1033:
1025:
629:
625:
4669:
4482:
4164:
4134:
3876:
3866:
3806:
3796:
3792:
3379:
2467:
1982:"theta, a novel gamma-aminobutyric acid type A receptor subunit"
1382:"The role of GABA(A) receptors in the development of alcoholism"
1154:
GABRA2 is associated with reward behavior when it activates the
1072:
1053:
61:
2913:
2153:
364:
3584:
2063:
alpha 5-containing human gamma-aminobutyric acidA receptors".
1388:. New Insights Into the Function of GABAA Receptor Subtypes.
1067:
chloride channels and are activated by the major inhibitory
1629:"GABAA receptor subtype involvement in addictive behaviour"
4180:
433:
inhibitory extracellular ligand-gated ion channel activity
1356:. New York: Humana Press. pp. 23–31, 69–87, 87–111.
216:
48:, gamma-aminobutyric acid type A receptor alpha2 subunit
4506:
2964:
2084:
Tögel M, Mossier B, Fuchs K, Sieghart W (April 1994).
338:
4504:
4495:
4178:
2962:
2953:
2848:
2835:
2795:
2730:
2660:
2648:
2626:
2476:
2426:
2252:
2204:
2195:
1909:
945:
864:
838:
805:
1252:
1250:
1248:
1579:Nature Reviews. Gastroenterology & Hepatology
163:
1622:
1620:
1618:
1043:Gamma-aminobutyric acid receptor subunit alpha-2
484:integral component of synaptic vesicle membrane
413:extracellular ligand-gated ion channel activity
1759:Drgon T, D'Addario C, Uhl GR (December 2006).
1532:Sullivan EV, Harris RA, Pfefferbaum A (2010).
2925:
2165:
610:regulation of postsynaptic membrane potential
8:
1427:
1425:
1375:
1373:
1347:
1345:
1343:
1341:
1339:
1337:
2941:
1673:Engin E, Liu J, Rudolph U (November 2012).
1432:Engin E, Liu J, Rudolph U (November 2012).
1257:GRCh38: Ensembl release 89: ENSG00000151834
1059:GABRA2 is an alpha subunit that is part of
4501:
4189:Tooltip γ-Aminobutyric acid A-rho receptor
2959:
2932:
2918:
2910:
2845:
2657:
2201:
2172:
2158:
2150:
2140:United States National Library of Medicine
861:
640:
380:
204:
101:
2129:at the U.S. National Library of Medicine
2101:
2015:
2005:
1962:
1784:
1741:
1698:
1644:
1598:
1549:
1534:"Alcohol's effects on brain and behavior"
1508:
1498:
1457:
1405:
550:gamma-aminobutyric acid signaling pathway
428:transmembrane signaling receptor activity
2138:This article incorporates text from the
1880:Brain Research. Molecular Brain Research
423:GABA-gated chloride ion channel activity
1722:Journal of Studies on Alcohol and Drugs
1244:
4514:Tooltip γ-Aminobutyric acid B receptor
2972:Tooltip γ-Aminobutyric acid A receptor
1487:Neuropsychiatric Disease and Treatment
1386:Pharmacology Biochemistry and Behavior
1083:(psychoactive drugs) that bind to the
18:
1573:Edenberg HJ, Foroud T (August 2013).
560:regulation of neurotransmitter levels
509:integral component of plasma membrane
168:
127:
122:
7:
4819:GABA metabolism/transport modulators
3215:Positive modulators (abridged; see
2090:The Journal of Biological Chemistry
1943:American Journal of Human Genetics
942:
835:
802:
778:
759:
735:
716:
690:
671:
343:
304:
242:
221:
14:
4750:Homotaurine (tramiprosate, 3-APS)
4248:-Chloroacetylcytosine arabinoside
3043:Homotaurine (tramiprosate, 3-APS)
1892:10.1016/j.molbrainres.2005.03.001
1215:activation in the insula and the
1049:in humans that is encoded by the
1691:10.1016/j.pharmthera.2012.08.006
1450:10.1016/j.pharmthera.2012.08.006
605:synaptic transmission, GABAergic
595:regulation of membrane potential
575:chloride transmembrane transport
408:benzodiazepine receptor activity
354:
347:
152:
145:
139:
114:
4042:Pentylenetetrazol (pentetrazol)
1679:Pharmacology & Therapeutics
1438:Pharmacology & Therapeutics
590:chemical synaptic transmission
454:integral component of membrane
365:More reference expression data
327:More reference expression data
1:
4801:Receptor/signaling modulators
3956:Isopregnanolone (sepranolone)
2103:10.1016/S0021-9258(18)99974-6
2047:10.1016/S0378-1119(98)00594-0
1538:Alcohol Research & Health
137:
4812:receptor positive modulators
3320:ergoloid (dihydroergotoxine)
494:cytoplasmic vesicle membrane
4841:Genes on human chromosome 4
615:inhibitory synapse assembly
580:ion transmembrane transport
4862:
4011:Nonsteroidal antiandrogens
1921:10.1016/j.bbrc.2004.02.098
1352:Hanns S, Möhler H (2007).
565:neurotransmitter transport
4792:
2732:Voltage- and ligand-gated
2189:ligand-gated ion channels
1855:10.1007/s10519-005-9041-8
1817:10.1007/s10519-006-9069-4
1734:10.15288/jsad.2007.68.625
1633:Genes, Brain and Behavior
1575:"Genetics and alcoholism"
1398:10.1016/j.pbb.2008.03.007
1292:"Mouse PubMed Reference:"
1274:"Human PubMed Reference:"
1013:
1008:
1004:
997:
981:
964:
949:
888:
857:
842:
809:
798:
785:
781:
766:
762:
753:
742:
738:
723:
719:
710:
697:
693:
678:
674:
665:
650:
643:
639:
623:
418:chloride channel activity
383:
379:
362:
346:
337:
324:
311:
307:
254:
245:
215:
207:
203:
186:
173:
136:
113:
104:
100:
55:
52:
42:
35:
30:
26:
21:
3560:sulfonmethane (sulfonal)
2131:Medical Subject Headings
1591:10.1038/nrgastro.2013.86
1071:in the mammalian brain,
459:chloride channel complex
398:GABA-A receptor activity
2478:Nicotinic acetylcholine
2007:10.1073/pnas.96.17.9891
1841:developmental stages".
970:Chr 4: 46.25 – 46.48 Mb
504:GABA-A receptor complex
4439:5α-Dihydroprogesterone
3986:Morphine-3-glucuronide
3646:Hyenachin (mellitoxin)
3531:Retigabine (ezogabine)
2065:Molecular Pharmacology
1380:Enoch MA (July 2008).
1180:
1108:
1039:
1031:
600:nervous system process
274:superior frontal gyrus
3827:Chlorophenylsilatrane
2185:cell surface receptor
2127:GABRA2+protein,+human
1481:Nuss P (2015-01-17).
1178:
1162:Clinical significance
1106:
1063:receptors, which are
1037:
1029:
489:postsynaptic membrane
286:primary visual cortex
278:middle temporal gyrus
4777:Negative modulators:
4657:Positive modulators:
4550:Arbaclofen placarbil
4436:Negative modulators:
4285:Positive modulators:
4070:Pregnenolone sulfate
3706:17-Phenylandrostenol
3688:Negative modulators:
3573:constituents (e.g.,
3543:constituents (e.g.,
3405:Neuroactive steroids
3382:constituents (e.g.,
3118:Neuroactive steroids
2850:Purinergic receptors
1777:10.1002/ajmg.b.30349
1145:behavioral disorders
403:ion channel activity
130:Chromosome 4 (human)
4366:Gabazine (SR-95531)
4356:CGP-36742 (SGS-742)
4064:dihydropicrotoxinin
3789:Bicyclic phosphates
3701:11-Ketoprogesterone
3636:Gabazine (SR-95531)
3461:pyrazolopyrimidines
2096:(17): 12993–12998.
1998:1999PNAS...96.9891B
1206:Adolescent behavior
585:signal transduction
499:cytoplasmic vesicle
3887:FG-7142 (ZK-31906)
3433:Nonbenzodiazepines
2618:β1δε - Muscle type
2197:Cys-loop receptors
2142:, which is in the
1500:10.2147/NDT.S58841
1181:
1126:psychoactive drugs
1109:
1040:
1032:
555:chloride transport
543:Biological process
447:Cellular component
391:Molecular function
94:GABRA2 - orthologs
4828:
4827:
4788:
4787:
4710:2-Hydroxysaclofen
4491:
4490:
4381:Isonipecotic acid
3746:Anabolic steroids
3716:α5IA (LS-193,268)
3626:Dihydrosecurinine
3511:Pyrazolopyridines
3280:potassium bromide
3278:compounds (e.g.,
3241:Anabolic steroids
3219:for a full list):
3073:Isonipecotic acid
2907:
2906:
2903:
2902:
2831:
2830:
2662:Ligand-gated only
2644:
2643:
1992:(17): 9891–9896.
1843:Behavior Genetics
1805:Behavior Genetics
1646:10.1111/gbb.12321
1363:978-1-59745-465-0
1354:The GABA Receptor
1217:Nucleus accumbens
1024:
1023:
1020:
1019:
993:
992:
960:
959:
939:
938:
853:
852:
832:
831:
794:
793:
775:
774:
749:
748:
732:
731:
706:
705:
687:
686:
635:
634:
519:neuron projection
514:dendrite membrane
375:
374:
371:
370:
333:
332:
320:
319:
301:
300:
266:postcentral gyrus
262:entorhinal cortex
199:
198:
16:Protein in humans
4853:
4535:4-Fluorophenibut
4515:
4511:
4502:
4371:Gaboxadol (THIP)
4288:Allopregnanolone
4190:
4186:
3921:Fluoroquinolones
3676:Thiocolchicoside
3496:Piperidinediones
3453:imidazopyridines
3409:allopregnanolone
3316:Dihydroergolines
3231:drinking alcohol
3122:allopregnanolone
3038:Gaboxadol (THIP)
2973:
2969:
2960:
2943:
2934:
2927:
2920:
2911:
2846:
2658:
2202:
2174:
2167:
2160:
2151:
2115:
2105:
2080:
2058:
2029:
2019:
2009:
1976:
1966:
1932:
1903:
1886:(1–2): 174–183.
1874:
1836:
1798:
1788:
1755:
1745:
1712:
1702:
1659:
1658:
1648:
1624:
1613:
1612:
1602:
1570:
1564:
1563:
1553:
1544:(1–2): 127–143.
1529:
1523:
1522:
1512:
1502:
1478:
1472:
1471:
1461:
1429:
1420:
1419:
1409:
1377:
1368:
1367:
1349:
1332:
1331:
1324:
1318:
1317:
1306:
1300:
1299:
1288:
1282:
1281:
1270:
1264:
1254:
1069:neurotransmitter
1006:
1005:
977:
972:
955:
943:
934:
862:
858:RefSeq (protein)
848:
836:
827:
803:
779:
760:
736:
717:
691:
672:
641:
381:
367:
358:
351:
344:
329:
305:
290:Brodmann area 46
270:Brodmann area 23
250:
248:Top expressed in
243:
222:
205:
195:
182:
171:
156:
149:
143:
132:
118:
102:
96:
47:
40:
19:
4861:
4860:
4856:
4855:
4854:
4852:
4851:
4850:
4831:
4830:
4829:
4824:
4811:
4784:
4513:
4510:
4487:
4215:Homohypotaurine
4188:
4184:
4174:
4047:Phenylsilatrane
3589:chloral hydrate
3556:Sulfonylalkanes
3445:cyclopyrrolones
3266:Benzodiazepines
3018:Dihydromuscimol
2971:
2968:
2949:
2938:
2908:
2899:
2827:
2821:
2813:
2791:
2726:
2640:
2622:
2617:
2609:- Ganglion type
2608:
2604:
2596:
2588:
2584:
2576:
2572:
2472:
2463:
2455:
2447:
2439:
2422:
2416:
2408:
2400:
2391:
2361:
2353:
2345:
2337:
2329:
2321:
2313:
2305:
2297:
2289:
2281:
2273:
2265:
2248:
2217:
2191:
2178:
2123:
2118:
2083:
2061:
2032:
1979:
1935:
1906:
1877:
1839:
1801:
1758:
1715:
1672:
1668:
1666:Further reading
1663:
1662:
1626:
1625:
1616:
1572:
1571:
1567:
1531:
1530:
1526:
1480:
1479:
1475:
1431:
1430:
1423:
1379:
1378:
1371:
1364:
1351:
1350:
1335:
1326:
1325:
1321:
1308:
1307:
1303:
1290:
1289:
1285:
1272:
1271:
1267:
1255:
1246:
1241:
1232:
1225:
1208:
1173:
1164:
1138:GABA-A receptor
1134:
1101:
1081:benzodiazepines
1015:View/Edit Mouse
1010:View/Edit Human
975:
968:
965:Location (UCSC)
951:
930:
926:
922:
918:
914:
910:
906:
902:
898:
894:
890:
884:
880:
876:
872:
868:
844:
823:
819:
815:
811:
726:ENSG00000151834
619:
538:
534:cell projection
474:plasma membrane
442:
363:
353:
352:
325:
316:
297:
294:caudate nucleus
292:
288:
284:
280:
276:
272:
268:
264:
260:
246:
190:
177:
169:
159:
158:
157:
150:
128:
105:Gene location (
56:
43:
36:
17:
12:
11:
5:
4859:
4857:
4849:
4848:
4843:
4833:
4832:
4826:
4825:
4823:
4822:
4815:
4809:
4804:
4797:
4793:
4790:
4789:
4786:
4785:
4783:
4782:
4773:
4772:
4767:
4762:
4757:
4752:
4747:
4742:
4737:
4732:
4727:
4722:
4717:
4712:
4703:
4702:
4697:
4692:
4687:
4682:
4677:
4672:
4667:
4662:
4653:
4652:
4647:
4642:
4637:
4632:
4630:Sodium oxybate
4627:
4622:
4617:
4612:
4607:
4602:
4597:
4592:
4587:
4582:
4577:
4572:
4567:
4562:
4557:
4552:
4547:
4542:
4537:
4532:
4527:
4525:1,4-Butanediol
4518:
4516:
4508:
4499:
4493:
4492:
4489:
4488:
4486:
4485:
4480:
4475:
4470:
4465:
4451:
4446:
4441:
4432:
4431:
4426:
4418:
4413:
4408:
4403:
4398:
4393:
4388:
4383:
4378:
4373:
4368:
4363:
4358:
4353:
4345:
4340:
4335:
4330:
4325:
4320:
4315:
4306:
4305:
4300:
4295:
4290:
4281:
4280:
4275:
4270:
4265:
4260:
4255:
4250:
4242:
4237:
4232:
4227:
4222:
4217:
4212:
4207:
4202:
4193:
4191:
4182:
4176:
4175:
4173:
4172:
4167:
4162:
4157:
4152:
4147:
4142:
4137:
4132:
4127:
4122:
4117:
4112:
4107:
4102:
4097:
4092:
4087:
4082:
4077:
4072:
4067:
4049:
4044:
4039:
4034:
4008:
4003:
3998:
3993:
3988:
3983:
3978:
3973:
3968:
3963:
3958:
3953:
3948:
3943:
3938:
3933:
3928:
3918:
3913:
3899:
3889:
3884:
3879:
3874:
3869:
3864:
3859:
3854:
3849:
3844:
3839:
3834:
3829:
3824:
3819:
3814:
3809:
3804:
3786:
3781:
3776:
3769:cephalosporins
3758:
3753:
3748:
3743:
3738:
3733:
3728:
3723:
3718:
3713:
3708:
3703:
3698:
3693:
3684:
3683:
3678:
3673:
3668:
3663:
3658:
3653:
3648:
3643:
3638:
3633:
3628:
3623:
3618:
3609:
3608:
3578:
3575:valerenic acid
3568:
3563:
3553:
3548:
3538:
3533:
3528:
3521:Quinazolinones
3518:
3508:
3503:
3493:
3488:
3478:
3473:
3468:
3430:
3425:
3420:
3402:
3397:
3392:
3387:
3377:
3367:
3362:
3357:
3343:
3340:mefenamic acid
3333:
3328:
3323:
3313:
3308:
3303:
3298:
3293:
3283:
3273:
3263:
3253:
3243:
3238:
3224:
3211:
3210:
3205:
3200:
3195:
3185:
3180:
3175:
3170:
3165:
3160:
3155:
3150:
3145:
3140:
3135:
3130:
3125:
3115:
3110:
3105:
3100:
3095:
3085:
3080:
3075:
3070:
3065:
3060:
3055:
3050:
3045:
3040:
3035:
3030:
3025:
3020:
3015:
3010:
3005:
3000:
2990:
2985:
2976:
2974:
2966:
2957:
2951:
2950:
2939:
2937:
2936:
2929:
2922:
2914:
2905:
2904:
2901:
2900:
2898:
2897:
2896:
2895:
2890:
2885:
2880:
2875:
2870:
2865:
2854:
2852:
2843:
2841:gated channels
2833:
2832:
2829:
2828:
2826:
2825:
2824:
2823:
2819:
2815:
2811:
2801:
2799:
2793:
2792:
2790:
2789:
2788:
2787:
2782:
2777:
2772:
2767:
2762:
2757:
2752:
2747:
2736:
2734:
2728:
2727:
2725:
2724:
2723:
2722:
2717:
2712:
2707:
2702:
2692:
2686:
2681:
2676:
2666:
2664:
2655:
2646:
2645:
2642:
2641:
2639:
2638:
2636:Zinc-activated
2632:
2630:
2624:
2623:
2621:
2620:
2615:
2611:
2606:
2602:
2598:
2594:
2590:
2586:
2582:
2578:
2574:
2570:
2562:
2561:
2556:
2551:
2546:
2541:
2536:
2531:
2526:
2521:
2516:
2511:
2506:
2501:
2496:
2491:
2482:
2480:
2474:
2473:
2471:
2470:
2465:
2461:
2457:
2453:
2449:
2445:
2441:
2437:
2432:
2430:
2424:
2423:
2421:
2420:
2419:
2418:
2414:
2410:
2406:
2402:
2398:
2389:
2385:
2384:
2383:
2378:
2373:
2368:
2363:
2359:
2355:
2351:
2347:
2343:
2339:
2335:
2331:
2327:
2323:
2319:
2315:
2311:
2307:
2303:
2299:
2295:
2291:
2287:
2283:
2279:
2275:
2271:
2263:
2258:
2256:
2250:
2249:
2247:
2246:
2245:
2244:
2239:
2234:
2229:
2224:
2215:
2210:
2208:
2206:5-HT/serotonin
2199:
2193:
2192:
2179:
2177:
2176:
2169:
2162:
2154:
2135:
2134:
2122:
2121:External links
2119:
2117:
2116:
2081:
2071:(6): 970–975.
2059:
2041:(2): 213–222.
2030:
1977:
1955:10.1086/383283
1949:(4): 705–714.
1933:
1915:(3): 636–642.
1904:
1875:
1849:(4): 577–590.
1837:
1811:(5): 640–650.
1799:
1771:(8): 854–860.
1756:
1728:(5): 625–633.
1713:
1685:(2): 142–152.
1669:
1667:
1664:
1661:
1660:
1639:(1): 149–184.
1614:
1585:(8): 487–494.
1565:
1524:
1473:
1444:(2): 142–152.
1421:
1369:
1362:
1333:
1319:
1301:
1283:
1265:
1243:
1242:
1240:
1237:
1236:
1235:
1230:
1224:
1221:
1207:
1204:
1172:
1169:
1163:
1160:
1133:
1130:
1100:
1097:
1022:
1021:
1018:
1017:
1012:
1002:
1001:
995:
994:
991:
990:
988:
986:
979:
978:
973:
966:
962:
961:
958:
957:
947:
946:
940:
937:
936:
886:
885:
859:
855:
854:
851:
850:
840:
839:
833:
830:
829:
807:
806:
800:
796:
795:
792:
791:
783:
782:
776:
773:
772:
764:
763:
757:
751:
750:
747:
746:
740:
739:
733:
730:
729:
721:
720:
714:
708:
707:
704:
703:
695:
694:
688:
685:
684:
676:
675:
669:
663:
662:
657:
652:
648:
647:
637:
636:
633:
632:
621:
620:
618:
617:
612:
607:
602:
597:
592:
587:
582:
577:
572:
567:
562:
557:
552:
546:
544:
540:
539:
537:
536:
531:
526:
521:
516:
511:
506:
501:
496:
491:
486:
481:
476:
471:
466:
461:
456:
450:
448:
444:
443:
441:
440:
435:
430:
425:
420:
415:
410:
405:
400:
394:
392:
388:
387:
377:
376:
373:
372:
369:
368:
360:
359:
341:
335:
334:
331:
330:
322:
321:
318:
317:
315:
312:
309:
308:
302:
299:
298:
296:
295:
291:
287:
283:
282:occipital lobe
279:
275:
271:
267:
263:
259:
255:
252:
251:
239:
238:
230:
219:
213:
212:
209:RNA expression
201:
200:
197:
196:
188:
184:
183:
175:
172:
167:
161:
160:
151:
144:
138:
134:
133:
126:
120:
119:
111:
110:
98:
97:
54:
50:
49:
41:
33:
32:
28:
27:
24:
23:
15:
13:
10:
9:
6:
4:
3:
2:
4858:
4847:
4844:
4842:
4839:
4838:
4836:
4821:
4820:
4816:
4814:
4813:
4805:
4803:
4802:
4798:
4795:
4794:
4791:
4781:
4778:
4775:
4774:
4771:
4768:
4766:
4763:
4761:
4758:
4756:
4753:
4751:
4748:
4746:
4743:
4741:
4738:
4736:
4733:
4731:
4728:
4726:
4723:
4721:
4718:
4716:
4713:
4711:
4708:
4705:
4704:
4701:
4698:
4696:
4693:
4691:
4688:
4686:
4683:
4681:
4678:
4676:
4673:
4671:
4668:
4666:
4663:
4661:
4658:
4655:
4654:
4651:
4648:
4646:
4643:
4641:
4638:
4636:
4633:
4631:
4628:
4626:
4623:
4621:
4618:
4616:
4613:
4611:
4608:
4606:
4603:
4601:
4598:
4596:
4593:
4591:
4588:
4586:
4583:
4581:
4578:
4576:
4573:
4571:
4568:
4566:
4563:
4561:
4558:
4556:
4553:
4551:
4548:
4546:
4543:
4541:
4540:Aceburic acid
4538:
4536:
4533:
4531:
4528:
4526:
4523:
4520:
4519:
4517:
4512:
4503:
4500:
4498:
4494:
4484:
4481:
4479:
4476:
4474:
4471:
4469:
4466:
4463:
4459:
4455:
4452:
4450:
4447:
4445:
4442:
4440:
4437:
4434:
4433:
4430:
4427:
4425:
4423:
4419:
4417:
4414:
4412:
4409:
4407:
4404:
4402:
4399:
4397:
4394:
4392:
4389:
4387:
4384:
4382:
4379:
4377:
4374:
4372:
4369:
4367:
4364:
4362:
4359:
4357:
4354:
4352:
4350:
4346:
4344:
4341:
4339:
4336:
4334:
4331:
4329:
4326:
4324:
4321:
4319:
4316:
4314:
4311:
4308:
4307:
4304:
4301:
4299:
4296:
4294:
4291:
4289:
4286:
4283:
4282:
4279:
4276:
4274:
4271:
4269:
4266:
4264:
4261:
4259:
4256:
4254:
4251:
4249:
4247:
4243:
4241:
4238:
4236:
4233:
4231:
4230:Ibotenic acid
4228:
4226:
4223:
4221:
4218:
4216:
4213:
4211:
4208:
4206:
4203:
4201:
4198:
4195:
4194:
4192:
4187:
4177:
4171:
4168:
4166:
4163:
4161:
4158:
4156:
4153:
4151:
4148:
4146:
4143:
4141:
4138:
4136:
4133:
4131:
4128:
4126:
4123:
4121:
4118:
4116:
4113:
4111:
4108:
4106:
4103:
4101:
4098:
4096:
4093:
4091:
4088:
4086:
4083:
4081:
4078:
4076:
4075:Propybicyphat
4073:
4071:
4068:
4065:
4061:
4057:
4053:
4050:
4048:
4045:
4043:
4040:
4038:
4037:Oenanthotoxin
4035:
4032:
4028:
4024:
4020:
4016:
4012:
4009:
4007:
4004:
4002:
3999:
3997:
3994:
3992:
3989:
3987:
3984:
3982:
3979:
3977:
3974:
3972:
3969:
3967:
3964:
3962:
3959:
3957:
3954:
3952:
3949:
3947:
3946:Iomazenil (I)
3944:
3942:
3939:
3937:
3934:
3932:
3929:
3926:
3925:ciprofloxacin
3922:
3919:
3917:
3914:
3911:
3907:
3906:amentoflavone
3903:
3900:
3897:
3893:
3890:
3888:
3885:
3883:
3880:
3878:
3875:
3873:
3870:
3868:
3865:
3863:
3860:
3858:
3855:
3853:
3850:
3848:
3845:
3843:
3842:Cyclothiazide
3840:
3838:
3835:
3833:
3830:
3828:
3825:
3823:
3820:
3818:
3815:
3813:
3810:
3808:
3805:
3802:
3798:
3794:
3790:
3787:
3785:
3782:
3780:
3777:
3774:
3770:
3766:
3762:
3759:
3757:
3754:
3752:
3749:
3747:
3744:
3742:
3739:
3737:
3734:
3732:
3729:
3727:
3724:
3722:
3719:
3717:
3714:
3712:
3709:
3707:
3704:
3702:
3699:
3697:
3694:
3692:
3689:
3686:
3685:
3682:
3679:
3677:
3674:
3672:
3669:
3667:
3664:
3662:
3659:
3657:
3654:
3652:
3649:
3647:
3644:
3642:
3639:
3637:
3634:
3632:
3631:Famiraprinium
3629:
3627:
3624:
3622:
3619:
3617:
3614:
3611:
3610:
3606:
3602:
3598:
3597:diethyl ether
3594:
3590:
3586:
3582:
3579:
3576:
3572:
3569:
3567:
3564:
3561:
3557:
3554:
3552:
3549:
3546:
3542:
3539:
3537:
3534:
3532:
3529:
3526:
3522:
3519:
3516:
3512:
3509:
3507:
3504:
3501:
3497:
3494:
3492:
3489:
3486:
3482:
3479:
3477:
3474:
3472:
3471:Norfluoxetine
3469:
3466:
3462:
3458:
3454:
3450:
3446:
3442:
3438:
3434:
3431:
3429:
3426:
3424:
3421:
3418:
3414:
3410:
3406:
3403:
3401:
3398:
3396:
3393:
3391:
3388:
3385:
3381:
3378:
3375:
3371:
3368:
3366:
3363:
3361:
3358:
3355:
3351:
3347:
3344:
3341:
3337:
3334:
3332:
3329:
3327:
3324:
3321:
3317:
3314:
3312:
3311:Clomethiazole
3309:
3307:
3306:Chlormezanone
3304:
3302:
3299:
3297:
3296:Carbamazepine
3294:
3291:
3287:
3284:
3281:
3277:
3274:
3271:
3267:
3264:
3261:
3260:phenobarbital
3257:
3254:
3251:
3247:
3244:
3242:
3239:
3236:
3232:
3228:
3225:
3223:
3220:
3218:
3213:
3212:
3209:
3206:
3204:
3201:
3199:
3196:
3193:
3189:
3186:
3184:
3181:
3179:
3176:
3174:
3171:
3169:
3166:
3164:
3163:Quisqualamine
3161:
3159:
3156:
3154:
3151:
3149:
3146:
3144:
3141:
3139:
3136:
3134:
3131:
3129:
3126:
3123:
3119:
3116:
3114:
3111:
3109:
3106:
3104:
3101:
3099:
3098:Methylglyoxal
3096:
3093:
3089:
3086:
3084:
3081:
3079:
3076:
3074:
3071:
3069:
3066:
3064:
3061:
3059:
3056:
3054:
3051:
3049:
3048:Ibotenic acid
3046:
3044:
3041:
3039:
3036:
3034:
3031:
3029:
3026:
3024:
3021:
3019:
3016:
3014:
3011:
3009:
3006:
3004:
3001:
2998:
2997:phenobarbital
2994:
2991:
2989:
2986:
2984:
2981:
2978:
2977:
2975:
2970:
2961:
2958:
2956:
2952:
2948:
2945:
2935:
2930:
2928:
2923:
2921:
2916:
2915:
2912:
2894:
2891:
2889:
2886:
2884:
2881:
2879:
2876:
2874:
2871:
2869:
2866:
2864:
2861:
2860:
2859:
2856:
2855:
2853:
2851:
2847:
2844:
2842:
2838:
2834:
2822:
2816:
2814:
2808:
2807:
2806:
2803:
2802:
2800:
2798:
2794:
2786:
2783:
2781:
2778:
2776:
2773:
2771:
2768:
2766:
2763:
2761:
2758:
2756:
2753:
2751:
2748:
2746:
2743:
2742:
2741:
2738:
2737:
2735:
2733:
2729:
2721:
2718:
2716:
2713:
2711:
2708:
2706:
2703:
2701:
2698:
2697:
2696:
2693:
2690:
2687:
2685:
2682:
2680:
2677:
2675:
2671:
2668:
2667:
2665:
2663:
2659:
2656:
2654:
2651:
2647:
2637:
2634:
2633:
2631:
2629:
2625:
2619:
2612:
2610:
2599:
2597:
2591:
2589:
2579:
2577:
2567:
2564:
2563:
2560:
2557:
2555:
2552:
2550:
2547:
2545:
2542:
2540:
2537:
2535:
2532:
2530:
2527:
2525:
2522:
2520:
2517:
2515:
2512:
2510:
2507:
2505:
2502:
2500:
2497:
2495:
2492:
2490:
2487:
2484:
2483:
2481:
2479:
2475:
2469:
2466:
2464:
2458:
2456:
2450:
2448:
2442:
2440:
2434:
2433:
2431:
2429:
2425:
2417:
2411:
2409:
2403:
2401:
2395:
2394:
2393:
2386:
2382:
2379:
2377:
2374:
2372:
2369:
2367:
2364:
2362:
2356:
2354:
2348:
2346:
2340:
2338:
2332:
2330:
2324:
2322:
2316:
2314:
2308:
2306:
2300:
2298:
2292:
2290:
2284:
2282:
2276:
2274:
2268:
2267:
2266:
2260:
2259:
2257:
2255:
2251:
2243:
2240:
2238:
2235:
2233:
2230:
2228:
2225:
2223:
2220:
2219:
2218:
2212:
2211:
2209:
2207:
2203:
2200:
2198:
2194:
2190:
2186:
2182:
2175:
2170:
2168:
2163:
2161:
2156:
2155:
2152:
2148:
2147:
2145:
2144:public domain
2141:
2132:
2128:
2125:
2124:
2120:
2113:
2109:
2104:
2099:
2095:
2091:
2087:
2082:
2078:
2074:
2070:
2066:
2060:
2056:
2052:
2048:
2044:
2040:
2036:
2031:
2027:
2023:
2018:
2013:
2008:
2003:
1999:
1995:
1991:
1987:
1983:
1978:
1974:
1970:
1965:
1960:
1956:
1952:
1948:
1944:
1940:
1934:
1930:
1926:
1922:
1918:
1914:
1910:
1905:
1901:
1897:
1893:
1889:
1885:
1881:
1876:
1872:
1868:
1864:
1860:
1856:
1852:
1848:
1844:
1838:
1834:
1830:
1826:
1822:
1818:
1814:
1810:
1806:
1800:
1796:
1792:
1787:
1782:
1778:
1774:
1770:
1766:
1762:
1757:
1753:
1749:
1744:
1739:
1735:
1731:
1727:
1723:
1719:
1714:
1710:
1706:
1701:
1696:
1692:
1688:
1684:
1680:
1676:
1671:
1670:
1665:
1656:
1652:
1647:
1642:
1638:
1634:
1630:
1623:
1621:
1619:
1615:
1610:
1606:
1601:
1596:
1592:
1588:
1584:
1580:
1576:
1569:
1566:
1561:
1557:
1552:
1547:
1543:
1539:
1535:
1528:
1525:
1520:
1516:
1511:
1506:
1501:
1496:
1492:
1488:
1484:
1477:
1474:
1469:
1465:
1460:
1455:
1451:
1447:
1443:
1439:
1435:
1428:
1426:
1422:
1417:
1413:
1408:
1403:
1399:
1395:
1392:(1): 95–104.
1391:
1387:
1383:
1376:
1374:
1370:
1365:
1359:
1355:
1348:
1346:
1344:
1342:
1340:
1338:
1334:
1329:
1323:
1320:
1315:
1311:
1305:
1302:
1297:
1293:
1287:
1284:
1279:
1275:
1269:
1266:
1262:
1258:
1253:
1251:
1249:
1245:
1238:
1234:
1227:
1226:
1222:
1220:
1218:
1212:
1205:
1203:
1201:
1196:
1191:
1189:
1184:
1177:
1170:
1168:
1161:
1159:
1157:
1152:
1150:
1146:
1141:
1139:
1131:
1129:
1127:
1123:
1119:
1115:
1105:
1098:
1096:
1092:
1088:
1086:
1082:
1078:
1074:
1070:
1066:
1062:
1057:
1055:
1052:
1048:
1044:
1036:
1028:
1016:
1011:
1007:
1003:
1000:
996:
989:
987:
984:
980:
974:
971:
967:
963:
956:
954:
948:
944:
941:
935:
933:
929:
925:
921:
917:
913:
909:
905:
901:
897:
893:
887:
883:
879:
875:
871:
867:
863:
860:
856:
849:
847:
841:
837:
834:
828:
826:
822:
818:
814:
808:
804:
801:
799:RefSeq (mRNA)
797:
790:
789:
784:
780:
777:
771:
770:
765:
761:
758:
756:
752:
745:
741:
737:
734:
728:
727:
722:
718:
715:
713:
709:
702:
701:
696:
692:
689:
683:
682:
677:
673:
670:
668:
664:
661:
658:
656:
653:
649:
646:
642:
638:
631:
627:
622:
616:
613:
611:
608:
606:
603:
601:
598:
596:
593:
591:
588:
586:
583:
581:
578:
576:
573:
571:
570:ion transport
568:
566:
563:
561:
558:
556:
553:
551:
548:
547:
545:
542:
541:
535:
532:
530:
527:
525:
522:
520:
517:
515:
512:
510:
507:
505:
502:
500:
497:
495:
492:
490:
487:
485:
482:
480:
479:cell junction
477:
475:
472:
470:
467:
465:
462:
460:
457:
455:
452:
451:
449:
446:
445:
439:
436:
434:
431:
429:
426:
424:
421:
419:
416:
414:
411:
409:
406:
404:
401:
399:
396:
395:
393:
390:
389:
386:
385:Gene ontology
382:
378:
366:
361:
357:
350:
345:
342:
340:
336:
328:
323:
313:
310:
306:
303:
293:
289:
285:
281:
277:
273:
269:
265:
261:
257:
256:
253:
249:
244:
241:
240:
237:
235:
231:
229:
228:
224:
223:
220:
218:
214:
210:
206:
202:
194:
189:
185:
181:
176:
166:
162:
155:
148:
142:
135:
131:
125:
121:
117:
112:
108:
103:
99:
95:
91:
87:
83:
79:
75:
71:
67:
63:
59:
51:
46:
39:
34:
29:
25:
20:
4846:Ion channels
4817:
4806:
4799:
4776:
4707:Antagonists:
4706:
4656:
4521:
4497:Metabotropic
4468:Pregnanolone
4462:picrotoxinin
4435:
4421:
4348:
4318:(S)-4-ACPBPA
4313:(S)-2-MeGABA
4310:Antagonists:
4309:
4284:
4273:Thiomuscimol
4245:
4196:
4060:picrotoxinin
4023:enzalutamide
4019:bicalutamide
3941:Golexanolone
3837:Cloflubicyne
3687:
3613:Antagonists:
3612:
3525:methaqualone
3500:glutethimide
3476:Petrichloral
3437:β-carbolines
3256:Barbiturates
3214:
3198:Thiomuscimol
3003:Beta-Alanine
2993:Barbiturates
2983:(+)-Catechin
2979:
2840:
2804:
2796:
2731:
2661:
2627:
2565:
2485:
2277:
2137:
2136:
2093:
2089:
2068:
2064:
2038:
2034:
1989:
1985:
1946:
1942:
1912:
1908:
1883:
1879:
1846:
1842:
1808:
1804:
1768:
1764:
1725:
1721:
1682:
1678:
1636:
1632:
1582:
1578:
1568:
1541:
1537:
1527:
1490:
1486:
1476:
1441:
1437:
1389:
1385:
1353:
1322:
1313:
1304:
1295:
1286:
1277:
1268:
1213:
1209:
1192:
1185:
1182:
1165:
1153:
1142:
1135:
1110:
1093:
1089:
1065:ligand-gated
1058:
1050:
1042:
1041:
950:
932:NP_001364084
928:NP_001364083
924:NP_001364082
920:NP_001364081
916:NP_001364080
912:NP_001364079
908:NP_001364078
904:NP_001364077
900:NP_001364076
896:NP_001364075
892:NP_001364074
889:
882:NP_001364073
878:NP_001317619
874:NP_001273756
870:NP_001107647
843:
825:NM_001330690
821:NM_001286827
817:NM_001114175
810:
786:
767:
743:
724:
698:
679:
659:
654:
258:frontal pole
232:
225:
53:External IDs
4780:Compound 14
4610:Lesogaberan
4449:Loreclezole
4386:Loreclezole
4323:(S)-4-ACPCA
4303:Lanthanides
4293:Alphaxolone
4235:Isoguvacine
4145:Terbequinil
4015:apalutamide
4006:Nicardipine
3966:Laudanosine
3773:carbapenems
3765:penicillins
3621:Coriamyrtin
3616:Bicuculline
3605:sevoflurane
3601:paraldehyde
3551:Stiripentol
3428:Niacinamide
3413:cholesterol
3395:Loreclezole
3290:meprobamate
3246:Avermectins
3113:Nefiracetam
3078:Kojic amine
3068:Isomuscimol
3063:Isoguvacine
2181:Ion channel
1493:: 165–175.
1314:Gene - NCBI
1116:and/or the
1114:hippocampus
524:postsynapse
191:46,475,230
178:46,248,427
31:Identifiers
4835:Categories
4635:SKF-97,541
4545:Arbaclofen
4454:Picrotoxin
4444:Bilobalide
4120:Suritozole
4110:Sarmazenil
4095:Ro 19-4603
4090:Ro 15-4513
4085:Radequinil
4052:Picrotoxin
4031:nilutamide
4001:Naltrexone
3936:Furosemide
3916:Flumazenil
3910:oroxylin A
3902:Flavonoids
3882:Etbicyphat
3812:Bilobalide
3779:Basmisanil
3666:Sinomenine
3661:Securinine
3656:Pitrazepin
3641:Hydrastine
3593:chloroform
3566:Topiramate
3506:Propanidid
3370:Imidazoles
3365:Flupirtine
3360:Fluoxetine
3354:hispidulin
3346:Flavonoids
3301:Chloralose
3286:Carbamates
3250:ivermectin
3188:Terpenoids
3133:PF-6372865
2988:Bamaluzole
2955:Ionotropic
2947:modulators
2653:glutamates
2650:Ionotropic
2566:pentamers:
1263:, May 2017
1239:References
1171:Alcoholism
1087:receptor.
236:(ortholog)
74:HomoloGene
4770:SKF-97541
4765:SCH-50911
4755:Phaclofen
4740:CGP-64213
4735:CGP-55845
4730:CGP-54626
4725:CGP-52432
4720:CGP-46381
4715:CGP-35348
4685:CGP-13501
4660:ADX-71441
4645:Tolgabide
4625:Progabide
4620:Picamilon
4605:Isovaline
4522:Agonists:
4424:-3-ACPBPA
4401:SKF-97541
4351:-3-ACPBPA
4278:Tolgabide
4258:Progabide
4253:Picamilon
4197:Agonists:
4105:RO4938581
4100:RO4882224
4027:flutamide
3961:L-655,708
3931:Flurothyl
3832:Cicutoxin
3817:Bupropion
3784:Bemegride
3761:β-Lactams
3751:Amiloride
3581:Volatiles
3515:etazolate
3491:Phenytoin
3449:zopiclone
3441:abecarnil
3400:Monastrol
3390:Lanthanum
3374:etomidate
3336:Fenamates
3331:Etifoxine
3326:Etazepine
3203:Tolgabide
3153:Progabide
3143:Picamilon
3128:Org 20599
3103:Monastrol
3083:L-838,417
2980:Agonists:
2486:monomers:
1188:Glutamate
1118:forebrain
1099:Structure
953:NP_032092
866:NP_000798
846:NM_008066
813:NM_000807
645:Orthologs
82:GeneCards
4796:See also
4760:Saclofen
4695:rac-BHFF
4690:GS-39783
4680:CGP-7930
4640:SL 75102
4615:Phenibut
4570:Gabamide
4555:Baclofen
4458:picrotin
4411:SR-95813
4406:SR-95318
4328:2-MeTACA
4240:Muscimol
4170:ZK-93426
4140:TCS-1105
4125:TB-21007
4056:picrotin
3996:Naloxone
3981:Morphine
3976:MaxiPost
3896:fipronil
3892:Fiproles
3862:(+)-DMBB
3857:Dieldrin
3756:Anisatin
3671:SR-42641
3571:Valerian
3545:baicalin
3541:Skullcap
3485:propofol
3465:zaleplon
3457:zolpidem
3350:apigenin
3270:diazepam
3227:Alcohols
3168:SL-75102
3158:Propofol
3138:Phenibut
3108:Muscimol
3092:honokiol
3058:iso-THIP
3053:iso-THAZ
3028:Gabamide
2944:receptor
2797:‘Orphan’
2055:10023064
2026:10449790
1973:15024690
1929:15033447
1900:15950776
1871:15513277
1863:16557364
1825:16622805
1795:16894595
1752:17690794
1709:22921455
1655:27539865
1609:23712313
1560:23579943
1519:25653526
1468:22921455
1416:18440057
1259:–
1233:receptor
1223:See also
1149:Diazepam
1132:Function
1077:Chloride
999:Wikidata
624:Sources:
529:dendrite
464:membrane
4665:BHF-177
4650:Tolibut
4560:BL-1020
4473:ROD-188
4338:4-ACPAM
4333:3-APMPA
4200:BL-1020
4160:U-93631
4155:Thujone
4080:PWZ-029
4054:(i.e.,
4013:(e.g.,
3991:MRK-016
3971:Lindane
3923:(e.g.,
3904:(e.g.,
3894:(e.g.,
3763:(e.g.,
3741:β-EMGBL
3651:PHP-501
3587:(e.g.,
3558:(e.g.,
3536:ROD-188
3523:(e.g.,
3513:(e.g.,
3498:(e.g.,
3483:(e.g.,
3481:Phenols
3463:(e.g.,
3455:(e.g.,
3447:(e.g.,
3439:(e.g.,
3435:(e.g.,
3407:(e.g.,
3372:(e.g.,
3348:(e.g.,
3338:(e.g.,
3318:(e.g.,
3288:(e.g.,
3276:Bromide
3268:(e.g.,
3258:(e.g.,
3248:(e.g.,
3229:(e.g.,
3222:α-EMTBL
3192:borneol
3190:(e.g.,
3173:Taurine
3120:(e.g.,
3090:(e.g.,
3088:Lignans
3008:BL-1020
2995:(e.g.,
2695:Kainate
2428:Glycine
2112:8175718
2077:8391122
1994:Bibcode
1964:1181946
1833:7491312
1786:3922197
1743:3285563
1700:3478960
1600:4056340
1551:3625995
1510:4303399
1459:3478960
1407:2577853
1261:Ensembl
1047:protein
755:UniProt
712:Ensembl
651:Species
630:QuickGO
469:synapse
211:pattern
38:Aliases
4700:KK-92A
4530:3-APPA
4298:ATHDOC
3852:DHEA-S
3691:1,3M1B
3423:Niacin
3384:kavain
2133:(MeSH)
2110:
2075:
2053:
2024:
2014:
1971:
1961:
1927:
1898:
1869:
1861:
1831:
1823:
1793:
1783:
1750:
1740:
1707:
1697:
1653:
1607:
1597:
1558:
1548:
1517:
1507:
1466:
1456:
1414:
1404:
1360:
1156:insula
1122:GABRA1
1085:GABA-A
1061:GABA-A
1051:GABRA2
985:search
983:PubMed
788:P26048
769:P47869
667:Entrez
339:BioGPS
86:GABRA2
62:137140
45:GABRA2
22:GABRA2
4590:GHBAL
4575:GABOB
4478:THDOC
4422:trans
4416:TPMPA
4391:P4MPA
4343:4-GBA
4225:GABOB
3951:IPTBO
3801:IPTBO
3736:β-CCP
3731:β-CCM
3726:β-CCE
3721:β-CCB
3681:Tutin
3585:gases
3417:THDOC
3033:GABOB
2017:22306
1867:S2CID
1829:S2CID
1045:is a
700:14395
660:Mouse
655:Human
626:Amigo
234:Mouse
227:Human
174:Start
107:Human
78:20217
70:95614
4808:GABA
4745:DAVA
4675:BSPP
4670:BHFF
4565:GABA
4507:GABA
4483:Zinc
4429:ZAPA
4376:I4AA
4361:DAVA
4268:TAMP
4263:TACA
4220:GABA
4210:CAMP
4205:CACA
4181:GABA
4165:Zinc
4150:TETS
4135:TBPS
4130:TBOB
4062:and
3877:EBOB
3872:DMPC
3867:DMCM
3847:DHEA
3822:CHEB
3807:BIDN
3797:TBPO
3793:TBPS
3711:α3IA
3696:3M2B
3380:Kava
3235:2M2B
3217:here
3208:ZAPA
3183:TAMP
3178:TACA
3023:GABA
3013:DAVA
2965:GABA
2942:GABA
2805:GluD
2740:NMDA
2670:AMPA
2628:Zinc
2614:(α1)
2605:(β4)
2601:(α1)
2593:(α7)
2585:(β2)
2581:(α4)
2573:(β4)
2569:(α3)
2388:GABA
2262:GABA
2254:GABA
2214:5-HT
2108:PMID
2073:PMID
2051:PMID
2035:Gene
2022:PMID
1969:PMID
1925:PMID
1896:PMID
1859:PMID
1821:PMID
1791:PMID
1769:141B
1748:PMID
1705:PMID
1651:PMID
1605:PMID
1556:PMID
1515:PMID
1464:PMID
1412:PMID
1358:ISBN
1229:GABA
1202:-β.
1073:GABA
1054:gene
681:2555
217:Bgee
170:4p12
165:Band
124:Chr.
58:OMIM
4600:GVL
4595:GHV
4585:GHB
4580:GBL
4396:P4S
4349:cis
4115:SCS
3459:),
3451:),
3443:),
3148:P4S
2858:P2X
2837:ATP
2785:L1B
2780:L1A
2529:α10
2098:doi
2094:269
2043:doi
2039:227
2012:PMC
2002:doi
1959:PMC
1951:doi
1917:doi
1913:316
1888:doi
1884:137
1851:doi
1813:doi
1781:PMC
1773:doi
1738:PMC
1730:doi
1695:PMC
1687:doi
1683:136
1641:doi
1595:PMC
1587:doi
1546:PMC
1505:PMC
1495:doi
1454:PMC
1446:doi
1442:136
1402:PMC
1394:doi
1200:EEG
1195:SNP
976:n/a
744:n/a
314:n/a
187:End
90:OMA
66:MGI
4837::
4460:,
4185:-ρ
4058:,
4029:,
4025:,
4021:,
4017:,
3908:,
3799:,
3795:,
3771:,
3767:,
3603:,
3599:,
3595:,
3591:,
3467:))
3415:,
3411:,
3352:,
3233:,
2775:3B
2770:3A
2765:2D
2760:2C
2755:2B
2750:2A
2549:β4
2544:β3
2539:β2
2534:β1
2524:α9
2519:α7
2514:α6
2509:α5
2504:α4
2499:α3
2494:α2
2489:α1
2392:-ρ
2187::
2183:,
2106:.
2092:.
2088:.
2069:43
2067:.
2049:.
2037:.
2020:.
2010:.
2000:.
1990:96
1988:.
1984:.
1967:.
1957:.
1947:74
1945:.
1941:.
1923:.
1911:.
1894:.
1882:.
1865:.
1857:.
1847:36
1845:.
1827:.
1819:.
1809:36
1807:.
1789:.
1779:.
1767:.
1763:.
1746:.
1736:.
1726:68
1724:.
1720:.
1703:.
1693:.
1681:.
1677:.
1649:.
1637:16
1635:.
1631:.
1617:^
1603:.
1593:.
1583:10
1581:.
1577:.
1554:.
1542:33
1540:.
1536:.
1513:.
1503:.
1491:11
1489:.
1485:.
1462:.
1452:.
1440:.
1436:.
1424:^
1410:.
1400:.
1390:90
1384:.
1372:^
1336:^
1312:.
1294:.
1276:.
1247:^
1128:.
1075:.
1056:.
628:/
193:bp
180:bp
88:;
84::
80:;
76::
72:;
68::
64:;
60::
4810:A
4509:B
4464:)
4456:(
4246:N
4183:A
4066:)
4033:)
3927:)
3912:)
3898:)
3803:)
3791:(
3775:)
3607:)
3583:/
3577:)
3562:)
3547:)
3527:)
3517:)
3502:)
3487:)
3419:)
3386:)
3376:)
3356:)
3342:)
3322:)
3292:)
3282:)
3272:)
3262:)
3252:)
3237:)
3194:)
3124:)
3094:)
2999:)
2967:A
2933:e
2926:t
2919:v
2893:7
2888:6
2883:5
2878:4
2873:3
2868:2
2863:1
2839:-
2820:2
2818:δ
2812:1
2810:δ
2745:1
2720:5
2715:4
2710:3
2705:2
2700:1
2691:)
2689:4
2684:3
2679:2
2674:1
2672:(
2616:2
2607:3
2603:2
2595:5
2587:3
2583:2
2575:3
2571:2
2559:ε
2554:δ
2468:β
2462:4
2460:α
2454:3
2452:α
2446:2
2444:α
2438:1
2436:α
2415:3
2413:ρ
2407:2
2405:ρ
2399:1
2397:ρ
2390:A
2381:θ
2376:π
2371:ε
2366:δ
2360:3
2358:γ
2352:2
2350:γ
2344:1
2342:γ
2336:3
2334:β
2328:2
2326:β
2320:1
2318:β
2312:6
2310:α
2304:5
2302:α
2296:4
2294:α
2288:3
2286:α
2280:2
2278:α
2272:1
2270:α
2264:A
2242:E
2237:D
2232:C
2227:B
2222:A
2216:3
2173:e
2166:t
2159:v
2146:.
2114:.
2100::
2079:.
2057:.
2045::
2028:.
2004::
1996::
1975:.
1953::
1931:.
1919::
1902:.
1890::
1873:.
1853::
1835:.
1815::
1797:.
1775::
1754:.
1732::
1711:.
1689::
1657:.
1643::
1611:.
1589::
1562:.
1521:.
1497::
1470:.
1448::
1418:.
1396::
1366:.
1330:.
1316:.
1298:.
1280:.
1231:A
109:)
92::
Text is available under the Creative Commons Attribution-ShareAlike License. Additional terms may apply.