315:
292:
189:
214:
566:
2226:
321:
220:
42:
1809:, Busfield S, Lagrue AH, Xiong X, Debili N, Chickering T, Le Couedic JP, Goodearl A, Dussault B, Fraser C, Vainchenker W, Villeval JL (Sep 2000). "Cloning, characterization, and functional studies of human and mouse glycoprotein VI: a platelet-specific collagen receptor from the immunoglobulin superfamily".
1210:
ENSG00000274050, ENSG00000278670, ENSG00000276211, ENSG00000277439, ENSG00000278316, ENSG00000275633, ENSG00000274566, ENSG00000275931, ENSG00000276065 GRCh38: Ensembl release 89: ENSG00000088053, ENSG00000274050, ENSG00000278670, ENSG00000276211, ENSG00000277439, ENSG00000278316, ENSG00000275633,
1148:
macromolecular components of the extracellular matrix, with collagen types I, III, and VI being the major forms found in blood vessels. Platelet interaction with collagen occurs as a 2-step procedure: (1) the initial adhesion to collagen is followed by (2) an activation step leading to platelet
68:
1140:
GPVI is a 58-kD platelet membrane glycoprotein that plays a crucial role in the collagen-induced activation and aggregation of platelets. Upon injury to the vessel wall and subsequent damage to the
1838:
Ezumi Y, Uchiyama T, Takayama H (Oct 2000). "Molecular cloning, genomic structure, chromosomal localization, and alternative splice forms of the platelet collagen receptor glycoprotein VI".
1284:
Ezumi Y, Uchiyama T, Takayama H (Oct 2000). "Molecular cloning, genomic structure, chromosomal localization, and alternative splice forms of the platelet collagen receptor glycoprotein VI".
2098:"Analysis of the interaction of platelet collagen receptor glycoprotein VI (GPVI) with collagen. A dimeric form of GPVI, but not the monomeric form, shows affinity to fibrous collagen"
1594:"Platelet activation and signal transduction by convulxin, a C-type lectin from Crotalus durissus terrificus (tropical rattlesnake) venom via the p62/GPVI collagen receptor"
1972:
Saving KL, Mankin PE, Gorman MJ (Feb 2002). "Differences in adhesion receptor expression between immature and older platelets and red blood cells of neonates and adults".
328:
227:
1939:"Glycoprotein VI-mediated platelet fibrinogen receptor activation occurs through calcium-sensitive and PKC-sensitive pathways without a requirement for secreted ADP"
2266:
1333:
Jandrot-Perrus M, Busfield S, Lagrue AH, Xiong X, Debili N, Chickering T, Le
Couedic JP, Goodearl A, Dussault B, Fraser C, Vainchenker W, Villeval JL (Sep 2000).
1335:"Cloning, characterization, and functional studies of human and mouse glycoprotein VI: a platelet-specific collagen receptor from the immunoglobulin superfamily"
2658:
1707:"The platelet collagen receptor glycoprotein VI is a member of the immunoglobulin superfamily closely related to FcalphaR and the natural killer receptors"
789:
770:
150:
2225:
2055:"Differential role of glycolipid-enriched membrane domains in glycoprotein VI- and integrin-mediated phospholipase Cgamma2 regulation in platelets"
2133:"Cloning and analysis of the thrombopoietin-induced megakaryocyte-specific glycoprotein VI promoter and its regulation by GATA-1, Fli-1, and Sp1"
1266:
2738:
2205:
1248:
2527:
1773:"Expression and function of the mouse collagen receptor glycoprotein VI is strictly dependent on its association with the FcRgamma chain"
1672:"A novel association of Fc receptor gamma-chain with glycoprotein VI and their co-expression as a collagen receptor in human platelets"
314:
2259:
1043:
2653:
1740:
Miura Y, Ohnuma M, Jung SM, Moroi M (May 2000). "Cloning and expression of the platelet-specific collagen receptor glycoprotein VI".
2575:
2570:
2704:
291:
1319:
1050:
1498:"Membrane glycoprotein IV (CD36) is physically associated with the Fyn, Lyn, and Yes protein-tyrosine kinases in human platelets"
2053:
Wonerow P, Obergfell A, Wilde JI, Bobe R, Asazuma N, Brdicka T, Leo A, Schraven B, HorejsĂ V, Shattil SJ, Watson SP (Jun 2002).
2532:
2368:
1629:"Glycoprotein VI is the collagen receptor in platelets which underlies tyrosine phosphorylation of the Fc receptor gamma-chain"
1235:
1214:
2308:
1144:
lining, exposure of the subendothelial matrix to blood flow results in deposition of platelets. Collagen fibers are the most
213:
188:
1231:
65:
2608:
2252:
1209:
2560:
1902:
Suzuki-Inoue K, Tulasne D, Shen Y, Bori-Sanz T, Inoue O, Jung SM, Moroi M, Andrews RK, Berndt MC, Watson SP (Jun 2002).
1372:
Suzuki-Inoue K, Tulasne D, Shen Y, Bori-Sanz T, Inoue O, Jung SM, Moroi M, Andrews RK, Berndt MC, Watson SP (Jun 2002).
130:
1169:
327:
226:
2648:
2198:
1551:"A patient with platelets deficient in glycoprotein VI that lack both collagen-induced aggregation and adhesion"
320:
219:
2177:
872:
138:
1904:"Association of Fyn and Lyn with the proline-rich domain of glycoprotein VI regulates intracellular signaling"
1374:"Association of Fyn and Lyn with the proline-rich domain of glycoprotein VI regulates intracellular signaling"
1160:
Complete or partial deficiency of GPVI in humans is a rare condition presenting as a mild bleeding disorder.
853:
849:
845:
841:
837:
827:
823:
819:
815:
811:
2474:
2470:
1154:
1149:
secretion, recruitment of additional platelets, and aggregation. In physiologic conditions, the resulting
1334:
2589:
2333:
2302:
202:
2010:
2630:
2191:
1806:
1509:
1129:
117:
1153:
is the initial hemostatic event limiting blood loss. However, exposure of collagen after rupture of
2640:
2617:
2598:
2580:
2275:
1742:
1026:
1001:
997:
971:
950:
946:
2283:
2173:
2041:
1997:
1658:
1484:
162:
1592:
Polgár J, Clemetson JM, Kehrel BE, Wiedemann M, Magnenat EM, Wells TN, Clemetson KJ (May 1997).
1005:
942:
2668:
2625:
2154:
2119:
2084:
2033:
1989:
1960:
1925:
1890:
1855:
1826:
1794:
1759:
1728:
1693:
1650:
1615:
1580:
1537:
1476:
1441:
1395:
1354:
1301:
1185:
110:
58:
2681:
2676:
2144:
2109:
2074:
2066:
2025:
1981:
1950:
1915:
1880:
1847:
1818:
1784:
1751:
1718:
1683:
1640:
1605:
1570:
1562:
1527:
1517:
1466:
1431:
1385:
1346:
1293:
407:
338:
282:
237:
1157:
is a major stimulus of thrombus formation associated with myocardial infarction or stroke.
565:
2348:
2327:
2313:
1145:
382:
158:
1513:
2686:
2079:
2054:
1771:
Nieswandt B, Bergmeier W, Schulte V, Rackebrandt K, Gessner JE, Zirngibl H (Aug 2000).
1755:
1645:
1628:
1575:
1550:
704:
699:
694:
689:
684:
668:
663:
658:
653:
648:
643:
638:
622:
617:
612:
607:
2732:
2499:
2423:
2378:
1985:
1869:"Protein kinase B is regulated in platelets by the collagen receptor glycoprotein VI"
1532:
1497:
1471:
1454:
1150:
594:
2045:
2001:
1662:
1488:
142:
41:
2696:
2542:
2507:
2011:"Interaction of calmodulin with the cytoplasmic domain of platelet glycoprotein VI"
1110:
400:
179:
166:
2550:
2485:
2456:
2438:
2413:
2403:
2358:
2292:
2009:
Andrews RK, Suzuki-Inoue K, Shen Y, Tulasne D, Watson SP, Berndt MC (Jun 2002).
1271:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1253:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1141:
2029:
1502:
Proceedings of the
National Academy of Sciences of the United States of America
1436:
1419:
483:
2466:
2428:
2388:
2383:
2373:
299:
196:
146:
1955:
1938:
1822:
1723:
1706:
1688:
1671:
1610:
1593:
1350:
2565:
2522:
2517:
2512:
2398:
2393:
1522:
1118:
734:
543:
421:
366:
353:
265:
252:
154:
2158:
2149:
2132:
2123:
2114:
2097:
2088:
2037:
1993:
1964:
1929:
1920:
1903:
1894:
1885:
1868:
1859:
1851:
1830:
1798:
1789:
1772:
1763:
1732:
1480:
1445:
1399:
1390:
1373:
1358:
1305:
1297:
1697:
1654:
1619:
1584:
1541:
1090:
1085:
2461:
2451:
2446:
1937:
Quinton TM, Ozdener F, Dangelmaier C, Daniel JL, Kunapuli SP (May 2002).
1114:
1074:
917:
898:
2713:
2555:
2070:
1705:
Clemetson JM, Polgar J, Magnenat E, Wells TN, Clemetson KJ (Oct 1999).
884:
801:
2244:
1566:
87:
2480:
2337:
1058:
756:
17:
1496:
Huang MM, Bolen JB, Barnwell JW, Shattil SJ, Brugge JS (Sep 1991).
2322:
2317:
1128:. It was first cloned in 2000 by several groups including that of
1627:
Gibbins JM, Okuma M, Farndale R, Barnes M, Watson SP (Aug 1997).
719:
715:
2342:
1125:
574:
134:
2248:
2187:
2183:
1420:"Platelet-collagen interaction: is GPVI the central receptor?"
1173:
2528:
Protein Z-related protease inhibitor (ZPI) (inhibits FX, FXI)
2234:: Crystal structure of human platelet Glycoprotein VI (GPVI)
1455:"GPVI and integrin alphaIIb beta3 signaling in platelets"
390:
2131:
Holmes ML, Bartle N, Eisbacher M, Chong BH (Dec 2002).
1453:
Watson SP, Auger JM, McCarty OJ, Pearce AC (Aug 2005).
2533:
Tissue factor pathway inhibitor (TFPI) (inhibits FIII)
555:
2695:
2667:
2639:
2616:
2607:
2541:
2498:
2437:
2412:
2357:
2291:
2282:
2096:Miura Y, Takahashi T, Jung SM, Moroi M (Nov 2002).
1840:
1549:Moroi M, Jung SM, Okuma M, Shinmyozu K (Nov 1989).
1286:
1019:
990:
964:
935:
2599:Thrombin-activatable fibrinolysis inhibitor (TAFI)
1227:
1225:
1223:
1205:
1203:
1201:
2659:Activated protein C–protein C inhibitor (APC–PCI)
1670:Tsuji M, Ezumi Y, Arai M, Takayama H (Sep 1997).
1211:ENSG00000274566, ENSG00000275931, ENSG00000276065
337:
236:
1121:. In humans, glycoprotein VI is encoded by the
700:enzyme linked receptor protein signaling pathway
2508:Antithrombin (inhibits FII, FIX, FX, FXI, FXII)
121:, BDPLT11, GPIV, GPVI, glycoprotein VI platelet
29:Protein-coding gene in the species Homo sapiens
1232:GRCm38: Ensembl release 89: ENSMUSG00000078810
2260:
2199:
1320:"Entrez Gene: GP6 glycoprotein VI (platelet)"
8:
2613:
2288:
2267:
2253:
2245:
2206:
2192:
2184:
806:
730:
590:
378:
277:
174:
76:
2576:Plasminogen activator inhibitor-2 (PAI-2)
2571:Plasminogen activator inhibitor-1 (PAI-1)
2176:at the U.S. National Library of Medicine
2148:
2113:
2078:
1954:
1919:
1884:
1788:
1722:
1687:
1644:
1609:
1574:
1531:
1521:
1470:
1435:
1389:
613:transmembrane signaling receptor activity
1974:Journal of Pediatric Hematology/Oncology
2221:
1197:
2369:High-molecular-weight kininogen (HMWK)
31:
1555:The Journal of Clinical Investigation
1459:Journal of Thrombosis and Haemostasis
669:integral component of plasma membrane
342:
303:
298:
241:
200:
195:
7:
2654:Thrombin–antithrombin complex (TAT)
2137:The Journal of Biological Chemistry
2102:The Journal of Biological Chemistry
1908:The Journal of Biological Chemistry
1873:The Journal of Biological Chemistry
1777:The Journal of Biological Chemistry
1711:The Journal of Biological Chemistry
1676:The Journal of Biological Chemistry
1598:The Journal of Biological Chemistry
1418:Nieswandt B, Watson SP (Jul 2003).
1378:The Journal of Biological Chemistry
2561:Tissue plasminogen activator (tPA)
2518:Protein S (cofactor for protein C)
1016:
987:
961:
932:
908:
889:
863:
780:
761:
560:
478:
416:
395:
25:
1867:Barry FA, Gibbins JM (Apr 2002).
2224:
1986:10.1097/00043426-200202000-00012
1472:10.1111/j.1538-7836.2005.01429.x
654:tetraspanin-enriched microdomain
564:
326:
319:
313:
290:
225:
218:
212:
187:
40:
2649:Prothrombin fragment 1+2 (F1+2)
2309:Platelet membrane glycoproteins
2513:Protein C (inhibits FV, FVIII)
639:integral component of membrane
575:More reference expression data
544:More reference expression data
456:right hemisphere of cerebellum
1:
1756:10.1016/S0049-3848(00)00182-1
1646:10.1016/S0014-5793(97)00926-5
311:
210:
2739:Genes on human chromosome 19
2389:Factor XII (Hageman factor)
2303:von Willebrand factor (vWF)
623:signaling receptor activity
2755:
2709:-antiplasmin complex (PAP)
2424:Factor III (tissue factor)
2030:10.1182/blood-2001-11-0008
1437:10.1182/blood-2002-12-3882
2219:
1267:"Mouse PubMed Reference:"
1249:"Human PubMed Reference:"
1089:
1084:
1080:
1073:
1057:
1038:
1023:
994:
983:
968:
939:
928:
915:
911:
896:
892:
883:
870:
866:
835:
809:
800:
787:
783:
768:
764:
755:
740:
733:
729:
713:
593:
589:
572:
563:
554:
541:
490:
481:
428:
419:
389:
381:
377:
360:
347:
310:
289:
280:
276:
259:
246:
209:
186:
177:
173:
128:
125:
115:
108:
103:
84:
79:
62:
57:
52:
48:
39:
34:
2631:β-Thromboglobulin (β-TG)
2178:Medical Subject Headings
1956:10.1182/blood.V99.9.3228
1823:10.1182/blood.V96.5.1798
1724:10.1074/jbc.274.41.29019
1689:10.1074/jbc.272.38.23528
1611:10.1074/jbc.272.21.13576
1351:10.1182/blood.V96.5.1798
1103:Platelet glycoprotein VI
1044:Chr 19: 55.01 – 55.04 Mb
2626:Platelet factor 4 (PF4)
2523:Protein Z (inhibits FX)
2457:Prothrombin (factor II)
2059:The Biochemical Journal
1523:10.1073/pnas.88.17.7844
1168:GPVI has been shown to
1155:atherosclerotic plaques
2682:Fibrinopeptide B (FpB)
2677:Fibrinopeptide A (FpA)
2349:Glycoprotein VI (GPVI)
2314:Glycoprotein Ib (GPIb)
2150:10.1074/jbc.M206127200
2115:10.1074/jbc.M204029200
1921:10.1074/jbc.M201012200
1886:10.1074/jbc.M200482200
1852:10.1006/bbrc.2000.3624
1790:10.1074/jbc.M003803200
1391:10.1074/jbc.M201012200
1298:10.1006/bbrc.2000.3624
1130:Martine Jandrot-Perrus
1117:which is expressed in
2500:Anticoagulant factors
2467:Fibrinogen (factor I)
2462:Thrombin (factor IIa)
2334:Glycoprotein IIb/IIIa
2328:Glycoprotein IX (GP9)
2295:(platelet activation)
659:extracellular exosome
464:primary visual cortex
452:cerebellar hemisphere
203:Chromosome 19 (human)
2687:Fibrin monomers (FM)
2543:Fibrinolytic factors
2361:(contact activation)
1051:Chr 7: 4.37 – 4.4 Mb
305:Chromosome 7 (mouse)
80:List of PDB id codes
53:Available structures
2641:Thrombin generation
2618:Platelet activation
2609:Coagulation markers
2284:Coagulation factors
2276:Coagulation cascade
2174:GPVI+protein,+human
1743:Thrombosis Research
1514:1991PNAS...88.7844H
705:leukocyte migration
685:platelet activation
2481:Fibrin (factor Ia)
2293:Primary hemostasis
2071:10.1042/BJ20020128
1783:(31): 23998–4002.
873:ENSMUSG00000078810
678:Biological process
632:Cellular component
601:Molecular function
2726:
2725:
2722:
2721:
2669:Fibrin generation
2494:
2493:
2414:Extrinsic pathway
2359:Intrinsic pathway
2242:
2241:
2108:(48): 46197–204.
1567:10.1172/JCI114318
1186:collagen receptor
1100:
1099:
1096:
1095:
1069:
1068:
1034:
1033:
1013:
1012:
979:
978:
958:
957:
924:
923:
905:
904:
879:
878:
860:
859:
796:
795:
777:
776:
725:
724:
695:blood coagulation
585:
584:
581:
580:
550:
549:
537:
536:
475:
474:
460:bone marrow cells
373:
372:
272:
271:
99:
98:
95:
94:
63:Ortholog search:
16:(Redirected from
2746:
2614:
2289:
2269:
2262:
2255:
2246:
2228:
2208:
2201:
2194:
2185:
2162:
2152:
2143:(50): 48333–41.
2127:
2117:
2092:
2082:
2065:(Pt 3): 755–65.
2049:
2015:
2005:
1968:
1958:
1933:
1923:
1898:
1888:
1863:
1834:
1807:Jandrot-Perrus M
1802:
1792:
1767:
1736:
1726:
1717:(41): 29019–24.
1701:
1691:
1682:(38): 23528–31.
1666:
1648:
1623:
1613:
1604:(21): 13576–83.
1588:
1578:
1545:
1535:
1525:
1492:
1474:
1449:
1439:
1404:
1403:
1393:
1369:
1363:
1362:
1330:
1324:
1323:
1316:
1310:
1309:
1281:
1275:
1274:
1263:
1257:
1256:
1245:
1239:
1229:
1218:
1207:
1082:
1081:
1053:
1046:
1029:
1017:
1008:
988:
984:RefSeq (protein)
974:
962:
953:
933:
909:
890:
864:
831:
807:
781:
762:
731:
618:collagen binding
591:
577:
568:
561:
546:
514:genital tubercle
486:
484:Top expressed in
479:
424:
422:Top expressed in
417:
396:
379:
369:
356:
345:
330:
323:
317:
306:
294:
278:
268:
255:
244:
229:
222:
216:
205:
191:
175:
169:
120:
113:
90:
77:
71:
50:
49:
44:
32:
21:
2754:
2753:
2749:
2748:
2747:
2745:
2744:
2743:
2729:
2728:
2727:
2718:
2708:
2691:
2663:
2635:
2603:
2593:
2584:
2537:
2490:
2433:
2416:(tissue factor)
2415:
2408:
2360:
2353:
2294:
2278:
2273:
2243:
2238:
2235:
2229:
2215:
2212:
2170:
2165:
2130:
2095:
2052:
2024:(11): 4219–21.
2013:
2008:
1971:
1936:
1914:(24): 21561–6.
1901:
1879:(15): 12874–8.
1866:
1837:
1817:(5): 1798–807.
1805:
1770:
1739:
1704:
1669:
1626:
1591:
1548:
1495:
1452:
1417:
1413:
1411:Further reading
1408:
1407:
1384:(24): 21561–6.
1371:
1370:
1366:
1345:(5): 1798–807.
1332:
1331:
1327:
1318:
1317:
1313:
1283:
1282:
1278:
1265:
1264:
1260:
1247:
1246:
1242:
1230:
1221:
1208:
1199:
1194:
1182:
1166:
1138:
1091:View/Edit Mouse
1086:View/Edit Human
1049:
1042:
1039:Location (UCSC)
1025:
1004:
1000:
996:
970:
949:
945:
941:
854:ENSG00000276065
852:
850:ENSG00000275931
848:
846:ENSG00000274566
844:
842:ENSG00000275633
840:
838:ENSG00000278316
830:
828:ENSG00000277439
826:
824:ENSG00000276211
822:
820:ENSG00000278670
818:
816:ENSG00000274050
814:
812:ENSG00000088053
810:
709:
673:
649:plasma membrane
627:
608:protein binding
573:
542:
533:
528:
524:
520:
516:
512:
508:
504:
500:
496:
482:
471:
468:skin of abdomen
466:
462:
458:
454:
450:
446:
442:
438:
434:
420:
364:
351:
343:
333:
332:
331:
324:
304:
281:Gene location (
263:
250:
242:
232:
231:
230:
223:
201:
178:Gene location (
167:GP6 - orthologs
129:
116:
109:
86:
64:
30:
23:
22:
15:
12:
11:
5:
2752:
2750:
2742:
2741:
2731:
2730:
2724:
2723:
2720:
2719:
2717:
2716:
2711:
2706:
2701:
2699:
2693:
2692:
2690:
2689:
2684:
2679:
2673:
2671:
2665:
2664:
2662:
2661:
2656:
2651:
2645:
2643:
2637:
2636:
2634:
2633:
2628:
2622:
2620:
2611:
2605:
2604:
2602:
2601:
2596:
2594:-Macroglobulin
2591:
2587:
2582:
2578:
2573:
2568:
2563:
2558:
2553:
2547:
2545:
2539:
2538:
2536:
2535:
2530:
2525:
2520:
2515:
2510:
2504:
2502:
2496:
2495:
2492:
2491:
2489:
2488:
2483:
2478:
2464:
2459:
2454:
2449:
2443:
2441:
2439:Common pathway
2435:
2434:
2432:
2431:
2426:
2420:
2418:
2410:
2409:
2407:
2406:
2401:
2396:
2391:
2386:
2381:
2376:
2371:
2365:
2363:
2355:
2354:
2352:
2351:
2346:
2340:
2331:
2325:
2320:
2305:
2299:
2297:
2286:
2280:
2279:
2274:
2272:
2271:
2264:
2257:
2249:
2240:
2239:
2237:
2236:
2230:
2223:
2220:
2217:
2216:
2213:
2211:
2210:
2203:
2196:
2188:
2182:
2181:
2169:
2168:External links
2166:
2164:
2163:
2128:
2093:
2050:
2006:
1969:
1949:(9): 3228–34.
1934:
1899:
1864:
1835:
1803:
1768:
1737:
1702:
1667:
1624:
1589:
1546:
1508:(17): 7844–8.
1493:
1465:(8): 1752–62.
1450:
1414:
1412:
1409:
1406:
1405:
1364:
1325:
1311:
1276:
1258:
1240:
1219:
1196:
1195:
1193:
1190:
1189:
1188:
1181:
1178:
1165:
1162:
1137:
1134:
1098:
1097:
1094:
1093:
1088:
1078:
1077:
1071:
1070:
1067:
1066:
1064:
1062:
1055:
1054:
1047:
1040:
1036:
1035:
1032:
1031:
1021:
1020:
1014:
1011:
1010:
992:
991:
985:
981:
980:
977:
976:
966:
965:
959:
956:
955:
937:
936:
930:
926:
925:
922:
921:
913:
912:
906:
903:
902:
894:
893:
887:
881:
880:
877:
876:
868:
867:
861:
858:
857:
833:
832:
804:
798:
797:
794:
793:
785:
784:
778:
775:
774:
766:
765:
759:
753:
752:
747:
742:
738:
737:
727:
726:
723:
722:
711:
710:
708:
707:
702:
697:
692:
687:
681:
679:
675:
674:
672:
671:
666:
661:
656:
651:
646:
641:
635:
633:
629:
628:
626:
625:
620:
615:
610:
604:
602:
598:
597:
587:
586:
583:
582:
579:
578:
570:
569:
558:
552:
551:
548:
547:
539:
538:
535:
534:
532:
531:
527:
523:
519:
515:
511:
507:
503:
499:
495:
491:
488:
487:
476:
473:
472:
470:
469:
465:
461:
457:
453:
449:
445:
441:
437:
433:
429:
426:
425:
413:
412:
404:
393:
387:
386:
383:RNA expression
375:
374:
371:
370:
362:
358:
357:
349:
346:
341:
335:
334:
325:
318:
312:
308:
307:
302:
296:
295:
287:
286:
274:
273:
270:
269:
261:
257:
256:
248:
245:
240:
234:
233:
224:
217:
211:
207:
206:
199:
193:
192:
184:
183:
171:
170:
127:
123:
122:
114:
106:
105:
101:
100:
97:
96:
93:
92:
82:
81:
73:
72:
61:
55:
54:
46:
45:
37:
36:
28:
24:
14:
13:
10:
9:
6:
4:
3:
2:
2751:
2740:
2737:
2736:
2734:
2715:
2712:
2710:
2703:
2702:
2700:
2698:
2694:
2688:
2685:
2683:
2680:
2678:
2675:
2674:
2672:
2670:
2666:
2660:
2657:
2655:
2652:
2650:
2647:
2646:
2644:
2642:
2638:
2632:
2629:
2627:
2624:
2623:
2621:
2619:
2615:
2612:
2610:
2606:
2600:
2597:
2595:
2588:
2586:
2579:
2577:
2574:
2572:
2569:
2567:
2564:
2562:
2559:
2557:
2554:
2552:
2549:
2548:
2546:
2544:
2540:
2534:
2531:
2529:
2526:
2524:
2521:
2519:
2516:
2514:
2511:
2509:
2506:
2505:
2503:
2501:
2497:
2487:
2484:
2482:
2479:
2476:
2472:
2468:
2465:
2463:
2460:
2458:
2455:
2453:
2450:
2448:
2445:
2444:
2442:
2440:
2436:
2430:
2427:
2425:
2422:
2421:
2419:
2417:
2411:
2405:
2402:
2400:
2397:
2395:
2392:
2390:
2387:
2385:
2382:
2380:
2379:Prekallikrein
2377:
2375:
2372:
2370:
2367:
2366:
2364:
2362:
2356:
2350:
2347:
2344:
2341:
2339:
2335:
2332:
2329:
2326:
2324:
2321:
2319:
2315:
2312:
2310:
2306:
2304:
2301:
2300:
2298:
2296:
2290:
2287:
2285:
2281:
2277:
2270:
2265:
2263:
2258:
2256:
2251:
2250:
2247:
2233:
2227:
2222:
2218:
2209:
2204:
2202:
2197:
2195:
2190:
2189:
2186:
2179:
2175:
2172:
2171:
2167:
2160:
2156:
2151:
2146:
2142:
2138:
2134:
2129:
2125:
2121:
2116:
2111:
2107:
2103:
2099:
2094:
2090:
2086:
2081:
2076:
2072:
2068:
2064:
2060:
2056:
2051:
2047:
2043:
2039:
2035:
2031:
2027:
2023:
2019:
2012:
2007:
2003:
1999:
1995:
1991:
1987:
1983:
1979:
1975:
1970:
1966:
1962:
1957:
1952:
1948:
1944:
1940:
1935:
1931:
1927:
1922:
1917:
1913:
1909:
1905:
1900:
1896:
1892:
1887:
1882:
1878:
1874:
1870:
1865:
1861:
1857:
1853:
1849:
1845:
1841:
1836:
1832:
1828:
1824:
1820:
1816:
1812:
1808:
1804:
1800:
1796:
1791:
1786:
1782:
1778:
1774:
1769:
1765:
1761:
1757:
1753:
1749:
1745:
1744:
1738:
1734:
1730:
1725:
1720:
1716:
1712:
1708:
1703:
1699:
1695:
1690:
1685:
1681:
1677:
1673:
1668:
1664:
1660:
1656:
1652:
1647:
1642:
1638:
1634:
1630:
1625:
1621:
1617:
1612:
1607:
1603:
1599:
1595:
1590:
1586:
1582:
1577:
1572:
1568:
1564:
1561:(5): 1440–5.
1560:
1556:
1552:
1547:
1543:
1539:
1534:
1529:
1524:
1519:
1515:
1511:
1507:
1503:
1499:
1494:
1490:
1486:
1482:
1478:
1473:
1468:
1464:
1460:
1456:
1451:
1447:
1443:
1438:
1433:
1430:(2): 449–61.
1429:
1425:
1421:
1416:
1415:
1410:
1401:
1397:
1392:
1387:
1383:
1379:
1375:
1368:
1365:
1360:
1356:
1352:
1348:
1344:
1340:
1336:
1329:
1326:
1321:
1315:
1312:
1307:
1303:
1299:
1295:
1291:
1287:
1280:
1277:
1272:
1268:
1262:
1259:
1254:
1250:
1244:
1241:
1237:
1233:
1228:
1226:
1224:
1220:
1216:
1212:
1206:
1204:
1202:
1198:
1191:
1187:
1184:
1183:
1179:
1177:
1175:
1171:
1163:
1161:
1158:
1156:
1152:
1151:platelet plug
1147:
1143:
1135:
1133:
1132:from INSERM.
1131:
1127:
1124:
1120:
1116:
1113:receptor for
1112:
1108:
1104:
1092:
1087:
1083:
1079:
1076:
1072:
1065:
1063:
1060:
1056:
1052:
1048:
1045:
1041:
1037:
1030:
1028:
1022:
1018:
1015:
1009:
1007:
1003:
999:
993:
989:
986:
982:
975:
973:
967:
963:
960:
954:
952:
948:
944:
938:
934:
931:
929:RefSeq (mRNA)
927:
920:
919:
914:
910:
907:
901:
900:
895:
891:
888:
886:
882:
875:
874:
869:
865:
862:
856:
855:
851:
847:
843:
839:
834:
829:
825:
821:
817:
813:
808:
805:
803:
799:
792:
791:
786:
782:
779:
773:
772:
767:
763:
760:
758:
754:
751:
748:
746:
743:
739:
736:
732:
728:
721:
717:
712:
706:
703:
701:
698:
696:
693:
691:
688:
686:
683:
682:
680:
677:
676:
670:
667:
665:
662:
660:
657:
655:
652:
650:
647:
645:
642:
640:
637:
636:
634:
631:
630:
624:
621:
619:
616:
614:
611:
609:
606:
605:
603:
600:
599:
596:
595:Gene ontology
592:
588:
576:
571:
567:
562:
559:
557:
553:
545:
540:
529:
525:
521:
517:
513:
509:
505:
501:
497:
493:
492:
489:
485:
480:
477:
467:
463:
459:
455:
451:
447:
443:
439:
435:
431:
430:
427:
423:
418:
415:
414:
411:
409:
405:
403:
402:
398:
397:
394:
392:
388:
384:
380:
376:
368:
363:
359:
355:
350:
340:
336:
329:
322:
316:
309:
301:
297:
293:
288:
284:
279:
275:
267:
262:
258:
254:
249:
239:
235:
228:
221:
215:
208:
204:
198:
194:
190:
185:
181:
176:
172:
168:
164:
160:
156:
152:
148:
144:
140:
136:
132:
124:
119:
112:
107:
102:
91:
89:
83:
78:
75:
74:
70:
67:
60:
56:
51:
47:
43:
38:
33:
27:
19:
2714:D-Dimer (DD)
2697:Fibrinolysis
2585:-Antiplasmin
2307:
2231:
2140:
2136:
2105:
2101:
2062:
2058:
2021:
2017:
1980:(2): 120–4.
1977:
1973:
1946:
1942:
1911:
1907:
1876:
1872:
1846:(1): 27–36.
1843:
1839:
1814:
1810:
1780:
1776:
1750:(4): 301–9.
1747:
1741:
1714:
1710:
1679:
1675:
1639:(2): 255–9.
1636:
1633:FEBS Letters
1632:
1601:
1597:
1558:
1554:
1505:
1501:
1462:
1458:
1427:
1423:
1381:
1377:
1367:
1342:
1338:
1328:
1314:
1292:(1): 27–36.
1289:
1285:
1279:
1270:
1261:
1252:
1243:
1167:
1164:Interactions
1159:
1146:thrombogenic
1139:
1122:
1111:glycoprotein
1106:
1102:
1101:
1027:NP_001156486
1024:
1002:NP_001242946
998:NP_001077368
995:
972:NM_001163014
969:
951:NM_001256017
947:NM_001083899
940:
916:
897:
871:
836:
788:
769:
749:
744:
644:cell surface
406:
399:
126:External IDs
85:
26:
2551:Plasminogen
2486:Factor XIII
2404:Factor VIII
2214:PDB gallery
1142:endothelial
498:bone marrow
448:granulocyte
344:7|7 A1
264:55,038,264
251:55,013,705
104:Identifiers
2429:Factor VII
2384:Kallikrein
2374:Bradykinin
1238:, May 2017
1217:, May 2017
1192:References
690:hemostasis
410:(ortholog)
365:4,400,743
352:4,366,964
147:HomoloGene
2705:Plasmin-α
2566:Urokinase
2399:Factor IX
2394:Factor XI
1119:platelets
1006:NP_057447
943:NM_016363
735:Orthologs
155:GeneCards
2733:Category
2452:Factor V
2447:Factor X
2159:12359731
2124:12356768
2089:12049640
2046:11271161
2038:12010829
2002:23735309
1994:11990697
1965:11964287
1930:11943772
1895:11825911
1860:11027634
1831:10961879
1799:10825177
1764:10822077
1733:10506151
1663:84145901
1489:42666713
1481:16102042
1446:12649139
1400:11943772
1359:10961879
1306:11027634
1234:–
1213:–
1180:See also
1170:interact
1136:Function
1115:collagen
1075:Wikidata
714:Sources:
664:membrane
526:skeleton
510:yolk sac
436:testicle
432:monocyte
243:19q13.42
2556:Plasmin
2080:1222625
1698:9295288
1655:9280292
1620:9153205
1585:2808700
1542:1715582
1510:Bibcode
1236:Ensembl
1215:Ensembl
1109:) is a
885:UniProt
802:Ensembl
741:Species
720:QuickGO
385:pattern
143:1889810
111:Aliases
2343:GPIIIa
2180:(MeSH)
2157:
2122:
2087:
2077:
2044:
2036:
2000:
1992:
1963:
1928:
1893:
1858:
1829:
1797:
1762:
1731:
1696:
1661:
1653:
1618:
1583:
1576:304007
1573:
1540:
1530:
1487:
1479:
1444:
1398:
1357:
1304:
1061:search
1059:PubMed
918:P0C191
899:Q9HCN6
790:243816
757:Entrez
556:BioGPS
506:zygote
502:spleen
135:605546
2338:GPIIb
2323:GP1BB
2318:GP1BA
2042:S2CID
2018:Blood
2014:(PDF)
1998:S2CID
1943:Blood
1811:Blood
1659:S2CID
1533:52400
1485:S2CID
1424:Blood
1339:Blood
1172:with
771:51206
750:Mouse
745:Human
716:Amigo
522:heart
518:liver
494:blood
444:blood
440:gonad
408:Mouse
401:Human
348:Start
283:Mouse
247:Start
180:Human
2232:2gi7
2155:PMID
2120:PMID
2085:PMID
2034:PMID
1990:PMID
1961:PMID
1926:PMID
1891:PMID
1856:PMID
1827:PMID
1795:PMID
1760:PMID
1729:PMID
1694:PMID
1651:PMID
1616:PMID
1581:PMID
1538:PMID
1477:PMID
1442:PMID
1396:PMID
1355:PMID
1302:PMID
1126:gene
1107:GPVI
391:Bgee
339:Band
300:Chr.
238:Band
197:Chr.
151:9488
131:OMIM
88:2GI7
69:RCSB
66:PDBe
18:GPVI
2475:FGG
2471:FGA
2145:doi
2141:277
2110:doi
2106:277
2075:PMC
2067:doi
2063:364
2026:doi
1982:doi
1951:doi
1916:doi
1912:277
1881:doi
1877:277
1848:doi
1844:277
1819:doi
1785:doi
1781:275
1752:doi
1719:doi
1715:274
1684:doi
1680:272
1641:doi
1637:413
1606:doi
1602:272
1571:PMC
1563:doi
1528:PMC
1518:doi
1467:doi
1432:doi
1428:102
1386:doi
1382:277
1347:doi
1294:doi
1290:277
1174:LYN
1123:GP6
530:leg
361:End
260:End
163:OMA
159:GP6
139:MGI
118:GP6
59:PDB
35:GP6
2735::
2473:,
2153:.
2139:.
2135:.
2118:.
2104:.
2100:.
2083:.
2073:.
2061:.
2057:.
2040:.
2032:.
2022:99
2020:.
2016:.
1996:.
1988:.
1978:24
1976:.
1959:.
1947:99
1945:.
1941:.
1924:.
1910:.
1906:.
1889:.
1875:.
1871:.
1854:.
1842:.
1825:.
1815:96
1813:.
1793:.
1779:.
1775:.
1758:.
1748:98
1746:.
1727:.
1713:.
1709:.
1692:.
1678:.
1674:.
1657:.
1649:.
1635:.
1631:.
1614:.
1600:.
1596:.
1579:.
1569:.
1559:84
1557:.
1553:.
1536:.
1526:.
1516:.
1506:88
1504:.
1500:.
1483:.
1475:.
1461:.
1457:.
1440:.
1426:.
1422:.
1394:.
1380:.
1376:.
1353:.
1343:96
1341:.
1337:.
1300:.
1288:.
1269:.
1251:.
1222:^
1200:^
1176:.
718:/
367:bp
354:bp
266:bp
253:bp
161:;
157::
153:;
149::
145:;
141::
137:;
133::
2707:2
2592:2
2590:α
2583:2
2581:α
2477:)
2469:(
2345:)
2336:(
2330:)
2316:(
2311::
2268:e
2261:t
2254:v
2207:e
2200:t
2193:v
2161:.
2147::
2126:.
2112::
2091:.
2069::
2048:.
2028::
2004:.
1984::
1967:.
1953::
1932:.
1918::
1897:.
1883::
1862:.
1850::
1833:.
1821::
1801:.
1787::
1766:.
1754::
1735:.
1721::
1700:.
1686::
1665:.
1643::
1622:.
1608::
1587:.
1565::
1544:.
1520::
1512::
1491:.
1469::
1463:3
1448:.
1434::
1402:.
1388::
1361:.
1349::
1322:.
1308:.
1296::
1273:.
1255:.
1105:(
285:)
182:)
165::
20:)
Text is available under the Creative Commons Attribution-ShareAlike License. Additional terms may apply.
