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288:. In 2010, Genzyme was the world's third-largest biotechnology company, employing more than 11,000 people around the world. As a subsidiary of Sanofi, Genzyme had a presence in approximately 65 countries, including 17 manufacturing facilities and 9 genetic-testing laboratories. Its products were also sold in 90 countries. In 2007, Genzyme generated $ 3.8 billion in revenue with more than 25 products on the market. In 2006 and 2007, Genzyme was named one of
398:, a previously rare, untreatable and potentially fatal genetic disorder. At the time, Ceredase also drew criticism for being the most expensive drug ever sold, on average $ 150,000 per patient a year. In 1991, Genzyme also took IG laboratories, acquired in 1989, public raising $ 14 million on IPO. Genzyme's also sold off its interest in GENE-TRAK systems for $ 10 million and acquired Genecore International's diagnostic enzyme division.
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In 2010, the year before the company's acquisition by Sanofi-Aventis, Genzyme had more than $ 400 million on net income on revenue of $ 4 billion and was the fourth-largest
American biopharmaceutical company. By this time, enzyme therapies accounted for about 40% of revenues, a portfolio managed by
389:
Following the approval and success of
Ceredase in 1991, Genzyme became devoted to finding drugs, involving recombinant human enzymes that would treat enzyme deficiency conditions that were essential to human survival and which usually afflict a very small percentage of the world's population. Drugs
332:
at Tufts
Medical School. Genzyme's first office was an old clothing warehouse adjacent to Tufts Medical School. In 1981, with the help of venture capital funding, the company made its first acquisition; Whatman Biochemicals Ltd. In 1982, it made its second acquisition, British-based Koch-Light
401:
In 1992, Genzyme acquired Medix
Biotech, Inc., a producer and supplier of monoclonal and polyclonal antibodies, immunoassay components, and immunodiagnostic services. In the same year, Genzyme Limited, acquired Enzymatix Ltd and genetics testing laboratory Vivigen.
1243:
in North
America. On May 29, 2007, Genzyme made a tender offer to purchase Bioenvision for $ 5.60 per share. On October 27, 2007, majority of shareholders voted to approve Genzyme's acquisition. In 2007, CEO, President, and Board Chairman
362:
along with the other seven patients who were all adults. This trial ultimately failed due to use of too low a dose of the enzyme, but
Ceredase went on to "become the company's most important product line", receiving FDA approval in 1991
412:, a genetically engineered replacement for Ceredase. The company acquired Sygena Ltd, BioSurface Technology Inc. and TSI Inc.. TSI was acquired by Genzyme Transgenics Corp. which was 73 percent owned by Genzyme.
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product
Seprafilm. Genzyme's sales representatives had been instructing surgeons on how to create a "slurry" using Seprafilm for use during laparoscopic surgeries. This use of Seprafilm is not FDA-approved.
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1289:, a rare genetic disorder that can lead to life-threatening organ damage. The FDA is permitting the drug to stay in the market, due to a lack of adverse events, and a critical need for the product.
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announced a bid to acquire
Genzyme for $ 18.5 billion. The deal was later rejected by the board of Genzyme. On February 16, 2011, Sanofi declared the full acquisition of Genzyme for $ 20.1 billion.
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in 1983 and worked to redirect the company, which by this time had reached a valuation of $ 100 million, from its focus on diagnostic enzymes to modified enzymes for use as human therapeutics.
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1300:, have been rationed to one-third the recommended dose prompting patients to file a petition asking for a license to produce Fabrazyme by other manufacturers to make up the deficit under the
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Genzyme had also reached a $ 22.28 million civil agreement pertaining to marketing of
Seprafilm in December 2013. Genzyme was claimed to be in violation of the federal False Claims Act.
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295:’s “100 Best Companies to Work for”. The company donated $ 83 million worth of products worldwide; in 2006, it made $ 11 million in cash donations. In 2005, Genzyme was awarded the
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Calabro, S. "Genzyme put patients first, and grew to become a multi-billion-dollar company. But empires don't survive on altruism." Pharmaceutical
Executive, <
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In November 2009, fragments of stainless steel, rubber, and fiber-like material were discovered in some of Genzyme's drugs. The FDA found these materials in
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the "Personalized Genetic Health" unit, the largest of five operating units. In the same year the company sold Genzyme Genetics for $ 925 million to
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The following is an illustration of the company's major mergers and acquisitions and historical predecessors (this is not a comprehensive list):
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2117). A similar event had occurred in 2008 at the Geel, Belgium facilities. By April 2010, it had restarted operation at diminished capacity.
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In 1993, the company acquired German distributor of invitro diagnostic kits, Virotech and immunobiological products manufacturer Omni Res srl.
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A Flair for the Business of Medicine: Genzyme founder Henry Blair started his career working as a technician at Tufts medical school
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In September 2015, Genzyme accepted responsibility and agreed to pay $ 32.59 million over U.S. charges against its marketing of the
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299:, the highest level of honor awarded by the president of the United States to America's leading innovators. In February 2022,
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Manufacturing Sites: Allston MA USA; Geel Belgium; Framingham, MA, USA; Haverhill, Suffolk UK; Waterford, Munster Ireland;
449:
In 2007, the company agreed to acquire Bioenvision for $ 345 million, motivated by the potential of the leukemia treatment
1994:
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from 2007 to 2009. In 2009 alone, it had 10 different organizations with a total of 49 lobbyists working on its behalf.
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440:'s laboratories and cancer-testing technologies in May 2004, after Impath sought Chapter 11 bankruptcy protection.
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http://www.pharmexec.com/pharmexec/article/articleDetail.jsp?id=310976&&pageID=7&searchString=genzyme
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https://web.archive.org/web/20061029102247/http://www.hirehealth.com/Public/CompanyDetails.aspx?COMPANY_ID=44719
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280:(also known as Genzyme Transgenics Corp or GTC Biotherapeutics) was an American biotechnology company based in
120:
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Awareness First Step Toward Treating Gaucher: article by TV Producer and Gaucher Patient, Mr. Michael Margolis
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In August 2003, the company acquired SangStat Medical Corp. and its principal anti-organ rejection drug named
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1527:"Eleven years after buying Genzyme, Sanofi officially ditches subsidiary's storied name - The Boston Globe"
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328:(NIH) to produce modified enzymes for the NIH to test in clinical trials. Blair was a technician at the
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1545:"All for one: Sanofi unveils modern new corporate brand — and bids adieu to Pasteur and Genzyme names"
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In June 2009, Genzyme's Allston, Massachusetts plant was shut down to correct a viral contamination (
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1743:"Genzyme scoops Impath for $ 215M: New assets will be merged into Westborough genetic testing unit"
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303:'s new corporate brand was unveiled and former entity "Sanofi Genzyme" got integrated into Sanofi.
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In 1984, Robin Berman, MD, who volunteered at the NIH, had a three-year-old son Brian, who had
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2008:
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Riskind. P. Multiple Sclerosis—The immune system's terrible mistake. Fall 1996, Vo. 5, No. 4.
1827:"Sanofi-aventis to Acquire Genzyme for $ 74.00 in Cash per Share Plus Contingent Value Right"
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1635:"Genzyme Corp facts, information, pictures - Encyclopedia.com articles about Genzyme Corp"
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284:. From its acquisition in 2011 to 2022 Genzyme operated as a fully owned subsidiary of
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In 1997, the company acquired PharmaGenics, Inc. creating Genzyme Molecular Oncology.
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1196:, genetics and diagnostics. The first orphan-drug for Genzyme that FDA approved was
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1248:, earned a salary of $ 2.5 million, and non-cash compensation worth $ 129 million.
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Schouten, E. "Genzyme's lifelong commitments". NRC Handelsblad. November 24, 2005.
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in 1981. Genzyme's scientific founder was Henry Blair who had a contract with the
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1999:
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https://web.archive.org/web/20060924143610/http://www.gaucher.org.uk/cercer.htm
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1503:. United States Patent and Trademark Office. February 19, 2009. Archived from
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In 2005, the company acquired Bone Care International Inc for $ 600 million.
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In 2004, the company acquired Ilex Oncology Inc. Genzyme acquired several of
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In 2010, Genzyme launched a kidney medication for the Irish market from its
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1873:. International Herald Tribune (France). Associated Press. October 22, 2007
1977:"With A Life-Saving Medicine In Short Supply, Patients Want Patent Broken"
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In 1999, Genzyme Surgical Products is established within the wider Group.
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Laboratories, later becoming Genzyme Pharmaceutical and Fine Chemicals.
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In 2000, the company announced its plan to acquire Biomatrix, Inc.
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2059:"Sanofi's Genzyme pays $ 32.59 million in criminal Seprafilm case"
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Glick, J. Leslie (September 1, 2015). "Innovation Strategies".
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Sanofi Genzyme headquarters in Cambridge, Massachusetts in 2007
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In 2006, the company acquired AnorMED Inc. for $ 580 million
1497:"The National Medal of Technology Recipients 2005 Laureates"
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1871:"Genzyme Claims Victory in Prolonged Bid for Bioenvision"
2037:"Sanofi could announce Genzyme deal next week – report"
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Defunct pharmaceutical companies of the United States
1809:"LabCorp acquires Genzyme Genetics for $ 925 million"
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Genzyme had a sub-license from Bioenvision to market
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Genzyme focuses on six areas of medicine relating to
1765:"AnorMED and Genzyme reach agreement on acquisition"
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The troubled Genzyme plant in Allston, Massachusetts
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1845:"Sanofi to buy Genzyme for more than $ 20 billion"
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408:In 1994, Genzyme received FDA approval to market
394:. Ceredase was the first effective treatment for
1791:"Genzyme snares cancer therapy in $ 345M buyout"
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1255:base which it had set up nine years previously.
1501:The National Medal of Technology and Innovation
1212:, used in treatment of dialysis patients, and
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1419:Genzyme has spent more than $ 8.2 million on
385:1990s: Product launches and further expansion
8:
2633:Health care companies based in Massachusetts
2623:Biotechnology companies of the United States
2618:Pharmaceutical companies established in 1981
1947:Genetic Engineering & Biotechnology News
1666:Genetic Engineering & Biotechnology News
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2628:Companies based in Cambridge, Massachusetts
2673:American subsidiaries of foreign companies
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1964:Steel, rubber, found in some genzyme drugs
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468:acquired the company for $ 20.1 billion.
1943:"Viral Safety Methods for Manufacturing"
1920:"New kidney disease medication launched"
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2648:National Medal of Technology recipients
2643:Companies formerly listed on the Nasdaq
1995:Genzyme Corp. "Client Profile: Summary"
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2017:
2006:
1896:. Henri Teemer profile. Archived from
1204:. Ceredase was eventually replaced by
366:In 1985, Termeer became the company's
7:
2658:1981 establishments in Massachusetts
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1220:. Other products in development are
1439:Lawsuit over marketing of Seprafilm
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2035:Regan, James (February 3, 2011).
1941:Angelo DePalma (April 15, 2010).
1704:"Genzyme Corp - Encyclopedia.com"
1558:Michael Rosenwald (August 2010).
690:(Diagnostic enzyme div, Acq 1991)
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1741:Craig M. Douglas (May 8, 2004).
1560:"Can Nanotechnology Save Lives?"
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1589:Bruce Morgan (April 12, 2012),
2663:1980s initial public offerings
1475:"Income Statement for Genzyme"
1216:, used to treat patients with
1:
2668:2011 mergers and acquisitions
1226:Clostridium difficile colitis
326:National Institutes of Health
170:
1966:. Reuters. November 13, 2009
1728:San Antonio Business Journal
1234:Chronic lymphocytic leukemia
354:but his mother pleaded with
297:National Medal of Technology
2498:Balmex Diaper Rash Ointment
1079:Bone Care International Inc
316:The company was started by
99:; 43 years ago
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1296:, Genzyme's treatment for
1285:, Genzyme's treatment for
1182:lysosomal storage diseases
883:BioSurface Technology Inc.
377:In 1989, Termeer acquired
171:More Complete Product List
2123:Genzyme corporate website
2115:February 7, 2012, at the
2091:Hirehealth's website <
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1922:. RTÉ. February 12, 2010
1892:Forbes (December 2007).
601:Whatman Biochemicals Ltd
282:Cambridge, Massachusetts
121:Cambridge, Massachusetts
1894:"Henri Termeer Profile"
1680:Michael Margolis (nd),
1262:Contamination incidents
1159:(Acquired by
629:Koch-Light Laboratories
372:took the company public
368:Chief executive officer
2339:Central nervous system
1271:
1200:, a drug for treating
1023:SangStat Medical Corp.
995:GelTex Pharmaceuticals
687:Genecore International
422:2000s: diversification
370:(CEO) and in 1986, he
339:joined Genzyme as its
2101:Hoovers’ website <
1815:. September 13, 2010.
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110:Boston, Massachusetts
1900:on December 28, 2001
1753:on November 5, 2012.
1708:www.encyclopedia.com
1639:www.encyclopedia.com
1564:Smithsonian Magazine
1431:On August 30, 2010,
662:(Acq 1989, IPO 1991)
322:George M. Whitesides
312:1980s: Early history
2229:Olivier Brandicourt
2128:OpenSecrets profile
2057:Stempel, Jonathan.
1851:. February 16, 2011
1163: in 2010)
715:Medix Biotech, Inc.
658:Integrated Genetics
472:Acquisition history
433:for $ 600 million.
379:Integrated Genetics
241:Number of employees
34:
18:Genzyme Corporation
2208:Marion Merrell Dow
1747:Milford Daily News
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1051:Ilex Oncology Inc.
939:PharmaGenics, Inc.
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2178:Sanofi-Synthélabo
1983:. August 4, 2010.
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2506:Cortizone-10
2466:Chattem Inc.
2171:Predecessors
2063:. Retrieved
2040:
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1998:
1989:
1980:
1971:
1959:
1950:
1946:
1936:
1926:February 12,
1924:. Retrieved
1914:
1902:. Retrieved
1898:the original
1887:
1877:November 10,
1875:. Retrieved
1865:
1853:. Retrieved
1848:
1839:
1830:
1821:
1812:
1803:
1794:
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1773:. Retrieved
1769:the original
1759:
1751:the original
1746:
1736:
1727:
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1682:
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1567:. Retrieved
1563:
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1511:February 26,
1509:. Retrieved
1505:the original
1500:
1491:
1479:. Retrieved
1450:
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1430:
1427:Takeover bid
1418:
1292:Supplies of
1291:
1280:
1273:
1257:
1250:
1238:
1179:
1154:
1135:Bioenvision
1134:
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827:Omni Res srl
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392:orphan drugs
388:
376:
365:
356:Roscoe Brady
345:
335:
315:
290:
277:
276:
116:Headquarters
59:Company type
29:
2545:Selsun Blue
2432:Proctosedyl
2427:Maalox Plus
2382:Bi-Profenid
2000:OpenSecrets
1595:, Tufts Now
1241:clofarabine
1190:orthopedics
451:clofarabine
143:Paul Hudson
140:Bill Sibold
79:: GENZ
2607:Categories
2567:Herpecin-L
2540:Aspercreme
2530:Kaopectate
2520:Ultra Swim
2387:Bronchicum
2271:Thrombosis
2018:|url=
1569:August 16,
1455:References
1315:Aldurazyme
1176:Operations
1138:(Acq 2007)
1110:(Acq 2006)
1082:(Acq 2005)
1054:(Acq 2004)
1026:(Acq 2003)
998:(Acq 2000)
970:(Acq 2000)
967:Biomatrix
942:(Acq 1997)
914:(Acq 1994)
886:(Acq 1994)
858:(Acq 1994)
855:Sygena Ltd
830:(Acq 1993)
802:(Acq 1993)
774:(Acq 1992)
746:(Acq 1992)
718:(Acq 1992)
632:(Acq 1982)
604:(Acq 1981)
218:Net income
133:Key people
63:Subsidiary
2573:New Phase
2564:Benzodent
2491:Gold Bond
2486:Allegra-D
2257:CoAprovel
2061:. Reuters
1481:March 16,
1370:Fabrazyme
1294:Fabrazyme
1276:Vesivirus
1253:Waterford
1222:Tolevamer
1214:Fabrazyme
464:In 2011,
341:president
159:Fabrazyme
71:Traded as
2570:Garlique
2560:Capzasin
2550:Nasacort
2535:Dexatrim
2437:Targocid
2407:Hemoclar
2392:Claforan
2313:Diabetes
2304:Eloxatin
2299:Taxotere
2292:Oncology
2198:Cassella
2113:Archived
2009:citation
1904:July 10,
1775:July 12,
1689:July 17,
1599:July 17,
1477:. Yahoo!
1421:lobbying
1415:Lobbying
1404:Taxotare
1400:Sarclisa
1395:Lumizyme
1385:Lemtrada
1365:Eloxatin
1360:Eloctate
1350:Dupixent
1340:Cerezyme
1335:Cerdelga
1320:Alprolix
1308:Products
1283:Cerezyme
1206:Cerezyme
1198:Ceredase
1194:oncology
911:TSI Inc.
799:Virotech
410:Cerezyme
360:Ceredase
293:magazine
155:Cerezyme
151:Products
84:Industry
2526:Premsyn
2523:Pamprin
2509:Flexall
2502:Rolaids
2481:Allegra
2452:Trental
2447:Telfast
2442:Tavanic
2377:Avipect
2362:Actonel
2283:Clexane
2262:Tritace
2252:Aprovel
2188:Hoechst
2183:Aventis
2041:Reuters
2020:value (
1981:npr.org
1855:May 14,
1849:Reuters
1408:Zaltrap
1390:Libtayo
1380:Kevzara
1375:Jevtana
1330:Cablivi
1325:Aubagio
1230:Campath
1210:Renagel
1155:Genzyme
771:Vivigen
584:Genzyme
459:LabCorp
307:History
291:Fortune
278:Genzyme
262:Website
233:million
209:million
185:billion
177:Revenue
167:Renagel
163:Synvisc
102: (
94:Founded
33:Genzyme
27:Company
2613:Sanofi
2555:Unisom
2517:Sun-In
2513:IcyHot
2474:Brands
2422:Maalox
2412:Lanzor
2402:Flagyl
2397:Daonil
2330:Lantus
2325:Apidra
2320:Amaryl
2278:Plavix
2164:Sanofi
2016:Check
2003:, 2008
1433:Sanofi
1355:Elitek
1345:Clolar
1161:Sanofi
466:Sanofi
438:Impath
301:Sanofi
286:Sanofi
256:Sanofi
251:Parent
77:Nasdaq
2417:Lasix
2367:Arava
229:US $
205:US $
183:4.61
181:US $
108:, in
2372:Avil
2217:CEOs
2119:>
2105:>
2095:>
2067:2015
2022:help
1953:(8).
1928:2010
1906:2008
1879:2007
1857:2020
1777:2017
1691:2015
1601:2015
1571:2012
1513:2009
1483:2007
1232:for
1228:and
1224:for
320:and
269:.com
231:421
207:581
104:1981
97:1981
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2049:^
2039:.
2013::
2011:}}
2007:{{
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1979:.
1951:30
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1945:.
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1829:.
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1793:.
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1726:.
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1637:.
1608:^
1579:^
1562:.
1529:.
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1463:^
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1930:.
1908:.
1881:.
1859:.
1833:.
1797:.
1779:.
1710:.
1641:.
1573:.
1547:.
1533:.
1515:.
1485:.
106:)
20:)
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