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in a half-step modus with 400 steps per rotation. These robots achieved spotting densities of more than 400 dots per square centimeter having been programmed for a spatial resolution of 0.015 mm over a moving length of 600 mm. A second generation of robots engineered from 1991 to 1992 achieved
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661:
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libraries transferred to 22 Ă— 22 cm nylon filters with the help of robots which have been developed by
Zehetner at the ICRF. The first-generation machines achieved a 1/100 mm resolution employing two-phase
479:
In Berlin the RZPD was first located at the Max Planck
Institute for Molecular Genetics in Berlin-Dahlem and then moved to a nearby site at the Harnack road (which today is the site of the
311:
for genetic clones worldwide and was associated with many of the major national and international gene and genome research projects. The RZPD was one of only two distributors in Europe for
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307:(BMBF) in order to provide the materials free of charge to the members of the DHGP, while they were available to other researchers at cost prize. The RZPD became the largest
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The
Reference Library System - sharing biological material and experimental data. GĂĽnther Zehetner and Hans Lehrach (3 February 1994).
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were made available to compare experimental results by researches using the globally standardized material provided by the center.
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On 31 July 2007 the non-profit company was disbanded. A large part of the existing services was taken over by two new companies.
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295:), GĂĽnther Zehetner (MPIMG, until July 2000 Scientific Director of the Berlin Resource Center) and Annemarie Poustka (
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The scope of services was constantly expanded and included the provision of genomic cell clones and cDNA databases,
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176:. Experimental results done with the standardized materials were reported back by researchers and collected in the
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180:. In January 1990 Zehetner was appointed as Associated Scientist at the ICRF under the then Director General Sir
393:, which was co-founded by Lehrach with the former department heads of the RZPD, Uwe Radelof und Bernd Drescher.
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Development of DNA Chips (DNA ARRAYS Technologies and experimental strategies, edited by Elena V. Grigorenko,
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339:
651:, Oxford Journals, briefings in Functional Genomics and Proteomics 2007, Volume 6, Number 3, pp. 163-170
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33:
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Development and perspectives of scientific services offered by genomic biological resource centers
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151:
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111:
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366:). As scientific company members served Hans Lehrach (MPIMG), Annemarie Poustka (DKFZ),
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Inc., Totowa, NJ), GĂĽnther
Zehetner, Maria Pack, and Katja Schäfer (2001), pp. 169-188
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Royal
College of Surgeons (centre) and Imperial Cancer Research Fund (right), London
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483:) before the center relocated to its final location at the former building of the
335:, which were kept, while not used for spotting, in deep freezers at -80 °C.
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In the summer of 1995, the
Resource Centre was established as part of the German
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generated at the ICRF to research groups worldwide. The macroarrays consisted of
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was supported by three of the most important research companies in
Germany: the
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RZPD wird ImaGenes – Wirtschaftlicher Erfolg ermöglicht Änderung der
Rechtsform
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established, while the planning was significantly influenced by the architect
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already a spotting density of up to 2500 dots per square centimeter utilizing
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291:(DHGP) by Hans Lehrach (Max Planck Institute for Molecular Genetics (MPIMG),
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506:. The small Heidelberg component of the center was located within the DKFZ.
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375:
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Preparation and screening of high-density cDNA arrays with
Genomic Clones (
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594:, vol 175:. Genomics Protocols, edited by: MP Starkey and R. Elaswarapu,
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building was constructed in the years 1907–1909 under the leadership of
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389:(a start-up company by the former managing directors of the RZPD) and
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119:
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53:
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and demolished in 2018 to make way for their new
Marshall Building.
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Early version of a spotting robot developed at the ICRF to generate
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The RLDB office in London was located in the main ICRF building at
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Symposia on Quant. Biol. 51), A. Poustka et al (1986), pp. 131-139
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building. The Lincoln's Inn Fields building was later sold to the
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303:(RZPD) it took over the work of the RLDB. It was funded by the
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Main building of the former ICRF in 2008 after it became the
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Germany to launch new gene programme ... (18 May 1995)
331:. Each clone was stored in a well of a 96 or 384 well
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In 1987 Hans Lehrach and GĂĽnther Zehetner founded the
468:and later moved to bigger premises in the adjacent
59:
43:
29:
21:
498:and Berlin City Commissioner for City Planning
481:Max Planck Institute for the History of Science
272:In early 1995 the RLDB moved to Berlin to the
338:On 1 July 2000 the RZPD was converted into a
8:
608:Max-Planck-Institut will Gen-Bank einrichten
564:Molecular approaches to mammalian genetics (
490:in Heubnerweg in Berlin-Charlottenburg. The
283:Frozen microtiter plates with library clones
16:
274:Max Planck Institute for Molecular Genetics
140:Reference Library / Primary Database (RLDB)
713:Genetics or genomics research institutions
360:Max DelbrĂĽck Center for Molecular Medicine
305:Federal Ministry of Education and Research
247:
92:German Resource Center for Genome Research
17:German Resource Center for Genome Research
15:
698:Biological research institutes in Germany
581:), Holger Eickhoff et al. (2002), pp. 1-9
419:Neo-baroque institute building in Berlin
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66:genomic cell clones and cDNA databases
344:Gesellschaft mit beschränkter Haftung
7:
540:"Germany warily maps genome project"
546:Vol. 268, Issue 5217, pp. 1556-1558
110:atenbank) was a service center for
662:""The Marshall Building location""
14:
301:Resource Center/Primary Database
263:filter membranes from clones in
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538:Kahn, Patricia (16 June 1995).
276:, where it continued its work.
448:offers. Data collected in the
348:company with limited liability
1:
718:Research institutes in Berlin
356:German Cancer Research Center
315:and also constructed its own
297:German Cancer Research Center
144:Imperial Cancer Research Fund
592:Methods in Molecular Biology
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723:Research support companies
474:London School of Economics
703:Companies based in Berlin
470:Royal College of Surgeons
402:London Research Institute
693:Bioinformatics companies
486:Empress Auguste Viktoria
299:(DKFZ), Heidelberg). As
150:. The RLDB distributed
639:GenomXPress 3/07, 2007
528:, vol 367, pp. 489-491
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370:(MDC) Matthias Uhlen (
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34:Berlin-Charlottenburg
462:Lincoln's Inn Fields
372:Karolinska Institute
289:Human Genome Project
708:Genetics in Germany
78:affymetrix services
75:expression profiles
18:
566:Cold Spring Harbor
421:
413:
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391:ATLAS Biolabs GmbH
352:Max Planck Society
285:
627:, vol 375, p. 175
380:Harald zur Hausen
313:IMAGE cDNA clones
265:microtiter plates
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664:. Archived from
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450:Primary Database
333:microtiter plate
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178:Primary Database
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346:(gGmbH). This
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169:stepper motors
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124:Charlottenburg
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25:service center
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668:on 2022-03-30
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293:Berlin-Dahlem
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215:^ Micro titer
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182:Walter Bodmer
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174:linear motors
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670:. Retrieved
666:the original
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596:Humana Press
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548:. Retrieved
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238:< Control
208:^ Macroarray
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139:
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118:research in
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89:
30:Headquarters
22:Company type
492:Neo-baroque
488:Infant Home
434:microarrays
364:Berlin-Buch
224:sterilizing
152:macroarrays
72:microarrays
45:Area served
687:Categories
672:2021-03-19
510:References
442:Affymetrix
440:profiles,
438:expression
368:Jens Reich
340:Non-Profit
261:macroarray
146:(ICRF) in
128:Heidelberg
81:PCR offers
38:Heidelberg
579:CRC Press
496:architect
456:Locations
376:Stockholm
329:libraries
327:and cDNA
201:head >
612:Die Welt
550:24 March
424:Services
387:ImaGenes
382:(DKFZ).
358:and the
309:database
240:computer
203:(Z-axis)
199:Spotting
98:esourcen
60:Services
544:Science
466:Holborn
317:plasmid
242:monitor
160:genomic
142:at the
134:History
102:entrum
94:(RZPD,
50:Germany
625:Nature
525:Nature
378:) and
354:, the
321:cosmid
231:drying
226:bath v
210:filter
156:clones
148:London
120:Berlin
116:genome
54:London
362:(MDC
233:mat v
217:plate
106:rimär
552:2021
222:Head
164:cDNA
162:and
126:and
114:and
112:gene
90:The
446:PCR
325:YAC
158:of
689::
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184:.
130:.
675:.
554:.
342:-
267:.
122:-
108:d
104:P
100:z
96:R
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