Knowledge (XXG)

Glycerol kinase

Source đź“ť

1828: 29: 1355: 1365: 1360: 1480: 1458: 1276: 166: 223: 185: 1386: 1885: 1281: 1448: 403:
lack glycerol kinase so they cannot metabolize the glycerol produced during triacyl glycerol degradation. This glycerol is instead shuttled to the
1087: 1904: 247: 1221: 423: 1547: 791: 585: 932: 235: 178: 467:
family 3.30.420.40. As of March 2010, there were 20 structures of this protein in the PDB, most of which are homodimeric.
228: 145: 121: 1703: 1878: 1505: 1500: 1060: 878: 1818: 1370: 1258: 1226: 1211: 893: 419: 1688: 1804: 1791: 1778: 1765: 1752: 1739: 1726: 1491: 1469: 1444: 1419: 1339: 947: 907: 852: 829: 801: 769: 635: 1698: 722: 139: 1871: 1652: 1595: 956: 937: 868: 602: 497: 288: 44: 126: 1600: 814: 1268: 1041: 951: 377: 240: 190: 1914: 1621: 1540: 1122: 1077: 779: 764: 700: 680: 578: 448: 114: 1693: 563: 1036: 1031: 911: 774: 754: 663: 385: 305: 1657: 1299: 1291: 1072: 739: 675: 639: 370: 142: 66: 1590: 1162: 1100: 1051: 786: 613: 359: 459:
Glycerol Kinase (alternative name, ATP:glycerol 3-phosphotransferase or Glycerokinase) adopts a
1909: 1177: 1167: 1157: 1082: 1066: 1025: 1011: 1006: 744: 707: 549: 133: 1855: 1636: 1631: 1605: 1533: 1510: 1172: 1152: 1094: 990: 888: 873: 819: 717: 712: 571: 539: 531: 300: 493: 309: 293: 102: 1683: 1667: 1580: 1433: 1423: 1245: 1216: 842: 749: 431: 329: 78: 49: 1832: 1721: 1662: 1401: 1240: 1147: 1139: 1016: 979: 544: 519: 161: 1898: 1626: 1585: 670: 1575: 759: 729: 658: 366: 264: 1799: 1734: 1570: 1325: 1315: 916: 653: 594: 339: 1827: 1127: 970: 883: 648: 598: 535: 427: 400: 271: 1773: 1747: 1406: 1319: 856: 622: 444: 553: 1253: 833: 520:"Dynamic dissociating homo-oligomers and the control of protein function" 476: 381: 276: 90: 1204: 1189: 805: 460: 109: 1851: 1848: 1786: 1556: 1182: 617: 481: 362: 259: 173: 85: 73: 61: 1760: 1199: 1194: 1046: 408: 404: 1356:
CDP-diacylglycerol—glycerol-3-phosphate 3-phosphatidyltransferase
1110: 1105: 1001: 996: 695: 690: 685: 464: 252: 97: 1529: 567: 28: 463:-like fold consisting of an alpha-beta 2-layer sandwich of 376:
Glycerol kinase catalyzes the transfer of a phosphate from
1525: 415:
Phosphorylated by glycerol kinase to glycerol 3-phosphate.
1859: 1816: 1366:
CDP-diacylglycerol—inositol 3-phosphatidyltransferase
1371:
CDP-diacylglycerol—choline O-phosphatidyltransferase
1712: 1676: 1645: 1614: 1563: 1490: 1468: 1443: 1418: 1399: 1379: 1361:
CDP-diacylglycerol—serine O-phosphatidyltransferase
1348: 1338: 1308: 1290: 1267: 1239: 1138: 978: 969: 946: 906: 851: 828: 800: 634: 610: 335: 325: 320: 299: 287: 282: 270: 258: 246: 234: 222: 214: 209: 204: 184: 172: 160: 155: 132: 120: 108: 96: 84: 72: 60: 55: 43: 38: 21: 1879: 1541: 579: 8: 1387:N-acetylglucosamine-1-phosphate transferase 1277:UTP—glucose-1-phosphate uridylyltransferase 1886: 1872: 1548: 1534: 1526: 1415: 1345: 975: 966: 631: 586: 572: 564: 317: 152: 1481:serine/threonine-specific protein kinases 1459:serine/threonine-specific protein kinases 1282:Galactose-1-phosphate uridylyltransferase 543: 496:at the U.S. National Library of Medicine 1823: 524:Archives of Biochemistry and Biophysics 510: 418:Converted from glycerol 3-phosphate to 201: 18: 7: 1844: 1842: 1858:. You can help Knowledge (XXG) by 518:Selwood T, Jaffe EK (March 2012). 424:glycerol 3-phosphate dehydrogenase 14: 792:Glucose-1,6-bisphosphate synthase 1826: 933:Ribose-phosphate diphosphokinase 27: 392:ATP + glycerol <=> ADP + 1: 1506:Protein-histidine tele-kinase 1501:Protein-histidine pros-kinase 1380:Glycosyl-1-phosphotransferase 33:glycerol kinase dimer, E.Coli 1212:RNA-dependent RNA polymerase 1905:Genes on human chromosome X 1119:RNA-directed DNA polymerase 987:DNA-directed DNA polymerase 1931: 1841: 1472:: protein-dual-specificity 426:. DHAP can participate in 420:dihydroxyacetone phosphate 1704:Michaelis–Menten kinetics 536:10.1016/j.abb.2011.11.020 443:This protein may use the 316: 151: 26: 1596:Diffusion-limited enzyme 1449:protein-serine/threonine 1349:Phosphatidyltransferases 938:Thiamine diphosphokinase 498:Medical Subject Headings 1854:-related article is a 1269:Nucleotidyltransferase 952:nucleotidyltransferase 879:Nucleoside-diphosphate 354:, encoded by the gene 1689:Eadie–Hofstee diagram 1622:Allosteric regulation 1123:Reverse transcriptase 449:allosteric regulation 396:-glycerol 3-phosphate 1699:Lineweaver–Burk plot 912:diphosphotransferase 894:Thiamine-diphosphate 601:-containing groups ( 386:glycerol 3-phosphate 371:glycerophospholipids 1494:: protein-histidine 1412:; protein acceptor) 1300:mRNA capping enzyme 1292:Guanylyltransferase 1658:Enzyme superfamily 1591:Enzyme promiscuity 770:Phosphoinositide 3 614:phosphotransferase 360:phosphotransferase 1867: 1866: 1814: 1813: 1523: 1522: 1519: 1518: 1395: 1394: 1334: 1333: 1235: 1234: 1148:Template-directed 902: 901: 869:Phosphomevalonate 439:Enzyme regulation 349: 348: 345: 344: 200: 199: 196: 195: 115:metabolic pathway 1922: 1888: 1881: 1874: 1843: 1831: 1830: 1822: 1694:Hanes–Woolf plot 1637:Enzyme activator 1632:Enzyme inhibitor 1606:Enzyme catalysis 1550: 1543: 1536: 1527: 1511:Histidine kinase 1434:tyrosine kinases 1424:protein-tyrosine 1416: 1346: 1153:RNA polymerase I 976: 967: 820:Aspartate kinase 815:Phosphoglycerate 632: 588: 581: 574: 565: 558: 557: 547: 515: 318: 202: 153: 31: 19: 1930: 1929: 1925: 1924: 1923: 1921: 1920: 1919: 1895: 1894: 1893: 1892: 1839: 1837: 1825: 1817: 1815: 1810: 1722:Oxidoreductases 1708: 1684:Enzyme kinetics 1672: 1668:List of enzymes 1641: 1610: 1581:Catalytic triad 1559: 1554: 1524: 1515: 1486: 1464: 1439: 1410: 1404: 1400:2.7.10-2.7.13: 1391: 1375: 1342:: miscellaneous 1330: 1304: 1286: 1263: 1246:exoribonuclease 1243: 1231: 1217:Polyadenylation 1134: 960: 954: 942: 924: 920: 914: 898: 860: 847: 824: 796: 626: 620: 612: 606: 592: 562: 561: 517: 516: 512: 507: 494:Glycerol+Kinase 490: 473: 457: 441: 432:gluconeogenesis 352:Glycerol kinase 205:glycerol kinase 34: 22:glycerol kinase 17: 12: 11: 5: 1928: 1926: 1918: 1917: 1912: 1907: 1897: 1896: 1891: 1890: 1883: 1876: 1868: 1865: 1864: 1836: 1835: 1812: 1811: 1809: 1808: 1795: 1782: 1769: 1756: 1743: 1730: 1716: 1714: 1710: 1709: 1707: 1706: 1701: 1696: 1691: 1686: 1680: 1678: 1674: 1673: 1671: 1670: 1665: 1660: 1655: 1649: 1647: 1646:Classification 1643: 1642: 1640: 1639: 1634: 1629: 1624: 1618: 1616: 1612: 1611: 1609: 1608: 1603: 1598: 1593: 1588: 1583: 1578: 1573: 1567: 1565: 1561: 1560: 1555: 1553: 1552: 1545: 1538: 1530: 1521: 1520: 1517: 1516: 1514: 1513: 1508: 1503: 1497: 1495: 1488: 1487: 1485: 1484: 1475: 1473: 1466: 1465: 1463: 1462: 1453: 1451: 1441: 1440: 1438: 1437: 1428: 1426: 1413: 1408: 1402:protein kinase 1397: 1396: 1393: 1392: 1390: 1389: 1383: 1381: 1377: 1376: 1374: 1373: 1368: 1363: 1358: 1352: 1350: 1343: 1336: 1335: 1332: 1331: 1329: 1328: 1323: 1312: 1310: 1306: 1305: 1303: 1302: 1296: 1294: 1288: 1287: 1285: 1284: 1279: 1273: 1271: 1265: 1264: 1262: 1261: 1256: 1250: 1248: 1241:Phosphorolytic 1237: 1236: 1233: 1232: 1230: 1229: 1224: 1219: 1214: 1209: 1208: 1207: 1202: 1197: 1187: 1186: 1185: 1175: 1170: 1165: 1160: 1155: 1150: 1144: 1142: 1140:RNA polymerase 1136: 1135: 1133: 1132: 1131: 1130: 1120: 1116: 1115: 1114: 1113: 1108: 1103: 1092: 1091: 1090: 1085: 1080: 1075: 1064: 1058: 1057: 1056: 1049: 1044: 1039: 1034: 1023: 1022: 1021: 1014: 1009: 1004: 999: 988: 984: 982: 980:DNA polymerase 973: 964: 958: 944: 943: 941: 940: 935: 929: 927: 922: 918: 904: 903: 900: 899: 897: 896: 891: 886: 881: 876: 871: 865: 863: 858: 849: 848: 846: 845: 839: 837: 826: 825: 823: 822: 817: 811: 809: 798: 797: 795: 794: 789: 784: 783: 782: 777: 767: 765:Diacylglycerol 762: 757: 752: 747: 742: 737: 732: 727: 726: 725: 715: 710: 705: 704: 703: 698: 693: 688: 683: 676:Phosphofructo- 673: 668: 667: 666: 656: 651: 645: 643: 629: 624: 608: 607: 593: 591: 590: 583: 576: 568: 560: 559: 509: 508: 506: 503: 502: 501: 489: 488:External links 486: 485: 484: 479: 472: 469: 461:ribonuclease H 456: 453: 440: 437: 436: 435: 416: 398: 397: 347: 346: 343: 342: 337: 333: 332: 327: 323: 322: 314: 313: 303: 297: 296: 291: 285: 284: 280: 279: 274: 268: 267: 262: 256: 255: 250: 244: 243: 238: 232: 231: 226: 220: 219: 216: 212: 211: 207: 206: 198: 197: 194: 193: 188: 182: 181: 176: 170: 169: 164: 158: 157: 149: 148: 137: 130: 129: 124: 118: 117: 112: 106: 105: 100: 94: 93: 88: 82: 81: 76: 70: 69: 64: 58: 57: 53: 52: 47: 41: 40: 36: 35: 32: 24: 23: 15: 13: 10: 9: 6: 4: 3: 2: 1927: 1916: 1913: 1911: 1908: 1906: 1903: 1902: 1900: 1889: 1884: 1882: 1877: 1875: 1870: 1869: 1863: 1861: 1857: 1853: 1850: 1845: 1840: 1834: 1829: 1824: 1820: 1806: 1802: 1801: 1796: 1793: 1789: 1788: 1783: 1780: 1776: 1775: 1770: 1767: 1763: 1762: 1757: 1754: 1750: 1749: 1744: 1741: 1737: 1736: 1731: 1728: 1724: 1723: 1718: 1717: 1715: 1711: 1705: 1702: 1700: 1697: 1695: 1692: 1690: 1687: 1685: 1682: 1681: 1679: 1675: 1669: 1666: 1664: 1663:Enzyme family 1661: 1659: 1656: 1654: 1651: 1650: 1648: 1644: 1638: 1635: 1633: 1630: 1628: 1627:Cooperativity 1625: 1623: 1620: 1619: 1617: 1613: 1607: 1604: 1602: 1599: 1597: 1594: 1592: 1589: 1587: 1586:Oxyanion hole 1584: 1582: 1579: 1577: 1574: 1572: 1569: 1568: 1566: 1562: 1558: 1551: 1546: 1544: 1539: 1537: 1532: 1531: 1528: 1512: 1509: 1507: 1504: 1502: 1499: 1498: 1496: 1493: 1489: 1483: 1482: 1477: 1476: 1474: 1471: 1467: 1461: 1460: 1455: 1454: 1452: 1450: 1446: 1442: 1436: 1435: 1430: 1429: 1427: 1425: 1421: 1417: 1414: 1411: 1403: 1398: 1388: 1385: 1384: 1382: 1378: 1372: 1369: 1367: 1364: 1362: 1359: 1357: 1354: 1353: 1351: 1347: 1344: 1341: 1337: 1327: 1324: 1321: 1317: 1314: 1313: 1311: 1307: 1301: 1298: 1297: 1295: 1293: 1289: 1283: 1280: 1278: 1275: 1274: 1272: 1270: 1266: 1260: 1257: 1255: 1252: 1251: 1249: 1247: 1242: 1238: 1228: 1225: 1223: 1220: 1218: 1215: 1213: 1210: 1206: 1203: 1201: 1198: 1196: 1193: 1192: 1191: 1188: 1184: 1181: 1180: 1179: 1176: 1174: 1171: 1169: 1166: 1164: 1161: 1159: 1156: 1154: 1151: 1149: 1146: 1145: 1143: 1141: 1137: 1129: 1126: 1125: 1124: 1121: 1118: 1117: 1112: 1109: 1107: 1104: 1102: 1099: 1098: 1096: 1093: 1089: 1086: 1084: 1081: 1079: 1076: 1074: 1071: 1070: 1068: 1065: 1062: 1059: 1055: 1054: 1050: 1048: 1045: 1043: 1040: 1038: 1035: 1033: 1030: 1029: 1027: 1024: 1020: 1019: 1015: 1013: 1010: 1008: 1005: 1003: 1000: 998: 995: 994: 992: 989: 986: 985: 983: 981: 977: 974: 972: 968: 965: 962: 953: 949: 945: 939: 936: 934: 931: 930: 928: 925: 913: 909: 905: 895: 892: 890: 887: 885: 882: 880: 877: 875: 872: 870: 867: 866: 864: 861: 854: 850: 844: 841: 840: 838: 835: 831: 827: 821: 818: 816: 813: 812: 810: 807: 803: 799: 793: 790: 788: 785: 781: 780:Class II PI 3 778: 776: 773: 772: 771: 768: 766: 763: 761: 758: 756: 755:Deoxycytidine 753: 751: 748: 746: 743: 741: 738: 736: 733: 731: 728: 724: 723:ADP-thymidine 721: 720: 719: 716: 714: 711: 709: 706: 702: 699: 697: 694: 692: 689: 687: 684: 682: 679: 678: 677: 674: 672: 669: 665: 662: 661: 660: 657: 655: 652: 650: 647: 646: 644: 641: 637: 633: 630: 627: 619: 615: 609: 604: 600: 596: 589: 584: 582: 577: 575: 570: 569: 566: 555: 551: 546: 541: 537: 533: 530:(2): 131–43. 529: 525: 521: 514: 511: 504: 499: 495: 492: 491: 487: 483: 480: 478: 475: 474: 470: 468: 466: 462: 454: 452: 450: 446: 438: 433: 429: 425: 421: 417: 414: 413: 412: 411:where it is: 410: 406: 402: 395: 391: 390: 389: 387: 384:thus forming 383: 379: 374: 372: 368: 367:triglycerides 364: 361: 357: 353: 341: 338: 334: 331: 328: 324: 319: 315: 312: 311: 307: 304: 302: 298: 295: 292: 290: 286: 281: 278: 275: 273: 269: 266: 263: 261: 257: 254: 251: 249: 245: 242: 239: 237: 233: 230: 227: 225: 221: 217: 213: 208: 203: 192: 189: 187: 183: 180: 177: 175: 171: 168: 165: 163: 159: 154: 150: 147: 144: 141: 138: 135: 131: 128: 125: 123: 119: 116: 113: 111: 107: 104: 101: 99: 95: 92: 91:NiceZyme view 89: 87: 83: 80: 77: 75: 71: 68: 65: 63: 59: 54: 51: 48: 46: 42: 37: 30: 25: 20: 1915:EC 2.7 stubs 1860:expanding it 1846: 1838: 1800:Translocases 1797: 1784: 1771: 1758: 1745: 1735:Transferases 1732: 1719: 1576:Binding site 1478: 1456: 1431: 1052: 1017: 775:Class I PI 3 740:Pantothenate 734: 611:2.7.1-2.7.4: 595:Transferases 527: 523: 513: 458: 442: 399: 393: 375: 365:involved in 355: 351: 350: 308: 79:BRENDA entry 1571:Active site 1326:Transposase 1316:Recombinase 961:-nucleoside 787:Sphingosine 422:(DHAP) via 373:synthesis. 330:Swiss-model 210:Identifiers 67:IntEnz view 39:Identifiers 1899:Categories 1774:Isomerases 1748:Hydrolases 1615:Regulation 1128:Telomerase 971:Polymerase 745:Mevalonate 708:Riboflavin 599:phosphorus 505:References 428:glycolysis 401:Adipocytes 326:Structures 321:Search for 283:Other data 136:structures 103:KEGG entry 1653:EC number 1320:Integrase 1244:3' to 5' 889:Guanylate 884:Uridylate 874:Adenylate 718:Thymidine 713:Shikimate 455:Structure 447:model of 445:morpheein 289:EC number 265:NM_000167 224:NCBI gene 56:Databases 1910:EC 2.7.1 1677:Kinetics 1601:Cofactor 1564:Activity 1254:RNase PH 862:acceptor 843:Creatine 836:acceptor 808:acceptor 750:Pyruvate 735:Glycerol 696:Platelet 671:Galacto- 642:acceptor 554:22182754 477:Glycerol 471:See also 407:via the 382:glycerol 340:InterPro 294:2.7.1.30 191:proteins 179:articles 167:articles 140:RCSB PDB 50:2.7.1.30 1833:Biology 1787:Ligases 1557:Enzymes 1205:PrimPol 1190:Primase 664:Hepatic 659:Fructo- 545:3298769 358:, is a 336:Domains 272:UniProt 127:profile 110:MetaCyc 1852:enzyme 1849:EC 2.7 1819:Portal 1761:Lyases 1492:2.7.13 1470:2.7.12 1445:2.7.11 1420:2.7.10 1259:PNPase 1227:PNPase 1183:POLRMT 1178:ssRNAP 691:Muscle 654:Gluco- 618:kinase 552:  542:  500:(MeSH) 482:Kinase 363:enzyme 306:Chr. X 277:P32189 260:RefSeq 253:300474 215:Symbol 174:PubMed 156:Search 146:PDBsum 86:ExPASy 74:BRENDA 62:IntEnz 45:EC no. 16:Enzyme 1847:This 1713:Types 1340:2.7.8 1309:Other 948:2.7.7 908:2.7.6 853:2.7.4 830:2.7.3 802:2.7.2 686:Liver 649:Hexo- 636:2.7.1 409:blood 405:liver 310:p21.3 301:Locus 122:PRIAM 1856:stub 1805:list 1798:EC7 1792:list 1785:EC6 1779:list 1772:EC5 1766:list 1759:EC4 1753:list 1746:EC3 1740:list 1733:EC2 1727:list 1720:EC1 1479:see 1457:see 1432:see 806:COOH 605:2.7) 550:PMID 465:CATH 369:and 248:OMIM 241:4289 236:HGNC 229:2710 186:NCBI 143:PDBe 98:KEGG 1222:PAP 1163:III 1097:/Y 1088:TDT 1069:/X 1061:III 1053:Pfu 1028:/B 1018:Taq 993:/A 760:PFP 730:NAD 540:PMC 532:doi 528:519 430:or 380:to 378:ATP 162:PMC 134:PDB 1901:: 1447:: 1422:: 1407:PO 1168:IV 1158:II 1067:IV 1063:/C 1026:II 1012:T7 957:PO 950:: 910:: 857:PO 855:: 832:: 804:: 640:OH 638:: 623:PO 603:EC 597:: 548:. 538:. 526:. 522:. 451:. 394:sn 388:: 356:GK 218:GK 1887:e 1880:t 1873:v 1862:. 1821:: 1807:) 1803:( 1794:) 1790:( 1781:) 1777:( 1768:) 1764:( 1755:) 1751:( 1742:) 1738:( 1729:) 1725:( 1549:e 1542:t 1535:v 1409:4 1405:( 1322:) 1318:( 1200:2 1195:1 1173:V 1111:Îş 1106:Îą 1101:η 1095:V 1083:ÎĽ 1078:λ 1073:β 1047:ζ 1042:ε 1037:δ 1032:α 1007:ν 1002:θ 997:Îł 991:I 963:) 959:4 955:( 926:) 923:7 921:O 919:2 917:P 915:( 859:4 834:N 701:2 681:1 628:) 625:4 621:( 616:/ 587:e 580:t 573:v 556:. 534:: 434:.

Index


EC no.
2.7.1.30
IntEnz
IntEnz view
BRENDA
BRENDA entry
ExPASy
NiceZyme view
KEGG
KEGG entry
MetaCyc
metabolic pathway
PRIAM
profile
PDB
RCSB PDB
PDBe
PDBsum
PMC
articles
PubMed
articles
NCBI
proteins
NCBI gene
2710
HGNC
4289
OMIM

Text is available under the Creative Commons Attribution-ShareAlike License. Additional terms may apply.

↑