498:
343:
846:
31:
677:
as a function of temperature and problems in mechanistic enzymology, and for his collaborative work with Dr. Scott Small of
Columbia University, which focuses on the retromer endosomal protein trafficking pathway and its role in Alzheimer's and Parkinson's diseases.
2407:
497:
598:
from
President Joe Biden. The National Medal of Science is the highest honor the United States can confer on a scientist; since the first was awarded in 1963 by President John F. Kennedy, only 506 individuals have received
606:
565:
as the director of the Helen and Robert Appel
Alzheimer's Disease Research Institute and the Arthur J. Mahon Professor of Neurology and Neuroscience in the Feil Family Brain and Mind Research Institute, and at
2392:
501:
President Joe Biden awards the
National Medal of Science to Professor Gregory A. Petsko of Harvard Medical School and Brigham & Women's Hospital on October 24, 2023. Photo by Jay Premack/USPTO.
1857:
1460:
Qureshi, Yasir H.; Berman, Diego E.; Marsh, Samuel E.; Klein, Ronald L.; Patel, Vivek M.; Simoes, Sabrina; Kannan, Suvarnambiga; Petsko, Gregory A.; Stevens, Beth; Small, Scott A. (2022).
526:
604:
522:
2397:
1782:
Mecozzi, Vincent J; Berman, Diego E; Simoes, Sabrina; Vetanovetz, Chris; Awal, Mehraj R; Patel, Vivek M; Schneider, Remy T; Petsko, Gregory A; Ringe, Dagmar; Small, Scott A (2014).
2402:
1850:
521:, where he was Professor of Biochemistry and of Chemistry and director of the Rosenstiel Basic Medical Sciences Research Center. He is past-president of the
1631:"Stabilizing the Retromer Complex in a Human Stem Cell Model of Alzheimer's Disease Reduces TAU Phosphorylation Independently of Amyloid Precursor Protein"
591:
239:
1843:
728:
506:
476:
161:
351:
919:
278:. On October 24, 2023, in a ceremony in the East Room of the White House, President Joe Biden presented Gregory Petsko and eight others with the
719:
1395:
Jensen, Anne Mette G.; Kitago, Yu; Fazeli, Elnaz; Vægter, Christian B.; Small, Scott A.; Petsko, Gregory A.; Andersen, Olav M. (2023-01-24).
993:
538:
510:
247:
165:
119:
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750:
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in
October 2016, and in January 2019 he followed her back to Boston, assuming his present position as Professor of Neurology at the
433:
575:
1866:
484:
737:
583:
579:
263:
255:
145:
1629:
Young, Jessica E.; Fong, Lauren K.; Frankowski, Harald; Petsko, Gregory A.; Small, Scott A.; Goldstein, Lawrence S.B. (2018).
2059:
2035:
804:
550:
414:
251:
124:
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as Gyula and Katica Tauber
Professor of Biochemistry and Chemistry, Emeritus. His wife was named president and CEO of the
562:
554:
542:
267:
149:
627:) that could therapeutically affect those biochemical targets, and seeing any resulting drug and gene therapy candidates
2309:
763:
705:
534:
530:
243:
114:
109:
931:
393:
367:
2261:
1995:
602:
595:
463:
279:
400:
786:
356:
2255:
1177:; Tsernoglou, D. (1979). "Temperature-dependent X-ray diffraction as a probe of protein structural dynamics".
861:
2339:
2327:
2243:
1228:
Schlichting, I.; Berendzen, J.; Chu, K.; Stock, A. M.; Maves, S. A.; Benson, D. E.; Sweet, R. M.; Ringe, D.;
467:
635:
360:
310:
305:, that could therapeutically affect those biochemical targets, and seeing any resulting clinical candidates
2291:
1397:"Dimerization of the Alzheimer's disease pathogenic receptor SORLA regulates its association with retromer"
382:
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2047:
817:
587:
459:
455:
259:
207:
141:
75:
2093:
1977:
1953:
1923:
693:
2213:
2153:
2111:
1893:
808:
670:
266:. He formerly had an endowed professorship (the Arthur J. Mahon Chair) in Neurology and Neuroscience at
2249:
2195:
2065:
2147:
2387:
2231:
2117:
2105:
2071:
2007:
2001:
1989:
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83:
66:
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1899:
1462:"The neuronal retromer can regulate both neuronal and microglial phenotypes of Alzheimer's disease"
1330:
Young, Jessica E.; Holstege, Henne; Andersen, Olav M.; Petsko, Gregory A.; Small, Scott A. (2023).
881:
781:
759:
571:
518:
275:
157:
70:
2041:
1983:
1764:
1680:"Endosomal Traffic Jams Represent a Pathogenic Hub and Therapeutic Target in Alzheimer's Disease"
1611:
1377:
1312:
1210:
790:
567:
451:
271:
153:
104:
2303:
274:, and is also the Gyula and Katica Tauber Professor, Emeritus, in biochemistry and chemistry at
2285:
2023:
1959:
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1538:
1522:
1481:
1473:
1432:
1416:
1359:
1343:
1296:
1249:
1232:; Sligar, S. G. (2000). "The Catalytic Pathway of Cytochrome P450cam at Atomic Resolution".
1194:
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620:
480:
290:
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Small, Scott A.; Simoes-Spassov, Sabrina; Mayeux, Richard; Petsko, Gregory A. (2017).
1567:
1135:
1118:
2361:
2321:
2237:
2225:
2135:
2087:
1971:
1965:
1941:
1935:
1615:
1381:
1332:"On the causal role of retromer-dependent endosomal recycling in Alzheimer's disease"
1331:
472:
968:
905:
2345:
2297:
2219:
2189:
2171:
2123:
1835:
1768:
1729:"Retromer in Alzheimer disease, Parkinson disease and other neurological disorders"
1316:
1214:
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682:
666:
643:
326:
314:
302:
1253:
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2165:
2129:
768:
624:
616:
294:
286:
282:, the highest honor the United States can bestow on a scientist and engineer.
1695:
1347:
570:
as adjunct professor of
Biomedical Engineering, and retained an appointment at
488:
370:. Contentious material about living people that is unsourced or poorly sourced
1030:
639:
483:, where he learned yeast genetics and molecular biology with the support of a
475:, studying enzymology at low temperatures. In 1996 he did a sabbatical at the
322:
318:
235:
1807:
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1599:
1534:
1428:
1355:
1084:
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1420:
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298:
2408:
Presidents of the
International Union of Biochemistry and Molecular Biology
1825:
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1607:
1552:
1495:
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1373:
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1144:
1103:
1049:
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1308:
1206:
1784:"Pharmacological chaperones stabilize retromer to limit APP processing"
882:"Recruited to lead Harvard med, 'fearless' scientist chose Dana-Farber"
741:
30:
777:
689:
who now have leadership roles in science. These individuals include:
557:
in New York City, where his wife, the world-renowned immunologist Dr.
1300:
1198:
184:
1744:
945:
906:"Biochemist Greg Petsko elected to American Philosophical Society"
496:
958:'Chaperone' compounds offer new approach to Alzheimer's treatment
662:. The first ten years of that column are available as an eBook.
619:
of neurological diseases like
Alzheimer's, Parkinson's, and ALS,
289:
of neurological diseases like
Alzheimer's, Parkinson's, and ALS,
1511:"Endosomal recycling reconciles the Alzheimer's disease paradox"
755:
1839:
270:
and is still an adjunct professor of Biomedical Engineering at
336:
285:
As of 2020 Petsko's research interests are understanding the
505:
Petsko's independent academic career has included stints at
450:, where he graduated summa cum laude in 1970. He received a
827:
673:
to solve important problems in protein function including
615:
Petsko's current research interests are understanding the
454:, and obtained his doctorate in Molecular Biophysics from
2393:
Members of the United States National Academy of Sciences
527:
International Union of Biochemistry and Molecular Biology
920:
Petsko set to leave University for New York City in 2014
685:
trained a large number of current leaders in structural
190:
523:
American Society for Biochemistry and Molecular Biology
515:
Max Planck Institute for Medical Research in Heidelberg
1279:(1990). "Molecular dynamics simulations in biology".
665:
Petsko is best known for his collaborative work with
471:
He did a brief postdoctoral fellowship in Paris with
1160:
Gregory Petsko in Genome Biology: The first 10 years
986:
Protein Structure and Function (Primers in Biology)
217:
201:
183:
137:
100:
90:
62:
37:
21:
1509:Small, Scott A.; Petsko, Gregory A. (2020-12-02).
309:. He has made key contributions to the fields of
191:Structural studies of triose phosphate isomerase.
932:No Stone Unturned: Interview with Gregory Petsko
650:. He was also the author of a monthly column in
561:, had been appointed dean. He was appointed at
254:. He is currently Professor of Neurology at the
1401:Proceedings of the National Academy of Sciences
941:
939:
918:Tate Herbert for The Justice November 13, 2012
553:. In 2012, he announced that he was moving to
634:Petsko's past research interests have been in
2398:Members of the American Philosophical Society
1851:
1568:"Elucidating the causes of neurodegeneration"
956:Columbia University Newsroom. April 20, 2014
8:
1727:Small, Scott A.; Petsko, Gregory A. (2015).
1566:Petsko, Gregory A.; Small, Scott A. (2022).
2403:Members of the National Academy of Medicine
462:, studying the structure and mechanism of
1858:
1844:
1836:
590:. On October 24, 2023, he and eight other
29:
18:
1815:
1703:
1654:
1542:
1485:
1436:
1363:
1134:
1093:
1083:
1039:
1029:
749:, professor and chair of biochemistry at
729:Max Planck Institute for Medical Research
580:Ann Romney Center for Neurologic Diseases
507:Wayne State University School of Medicine
477:University of California at San Francisco
434:Learn how and when to remove this message
256:Ann Romney Center for Neurologic Diseases
162:Wayne State University School of Medicine
545:and has an honorary Doctor of Laws from
930:Weill Cornell Newsroom. April 16, 2014
872:
549:. In April 2010, he was elected to the
798:, professor and chair of chemistry at
720:Fred Hutchinson Cancer Research Center
539:American Academy of Arts and Sciences
511:Massachusetts Institute of Technology
248:American Academy of Arts and Sciences
234:(born August 7, 1948) is an American
120:American Academy of Arts and Sciences
7:
1877:Paul-Lewis Award in Enzyme Chemistry
988:. Oxford : Oxford University Press.
654:modelled after an amusing column in
464:the enzyme triosephosphate isomerase
751:Albert Einstein College of Medicine
702:University of California, Berkeley
14:
529:. He is an elected member of the
1867:Pfizer Award in Enzyme Chemistry
844:
541:. He is a foreign member of the
485:Guggenheim Foundation Fellowship
341:
16:American biochemist and academic
738:Howard Hughes Medical Institute
446:Petsko was an undergraduate at
1515:Science Translational Medicine
1158:Petsko, Gregory (2010-10-10).
880:Bailey, Melissa (2016-03-01).
648:Protein Structure and Function
551:American Philosophical Society
252:American Philosophical Society
125:American Philosophical Society
1:
1254:10.1126/science.287.5458.1615
1136:10.1016/s0960-9822(02)01241-1
563:Weill Cornell Medical College
555:Weill Cornell Medical College
543:Hungarian Academy of Sciences
517:, and, from 1991 until 2012,
268:Weill Cornell Medical College
150:Weill Cornell Medical College
1647:10.1016/j.stemcr.2018.01.031
1527:10.1126/scitranslmed.abb1717
1478:10.1016/j.celrep.2021.110262
764:National Academy of Sciences
706:National Academy of Sciences
704:(Kuriyan is a member of the
681:At MIT and Brandeis, he and
584:Brigham and Women's Hospital
576:Dana–Farber Cancer Institute
535:National Academy of Medicine
531:National Academy of Sciences
352:biography of a living person
264:Brigham and Women's Hospital
244:National Academy of Medicine
240:National Academy of Sciences
146:Brigham and Women's Hospital
115:National Academy of Medicine
110:National Academy of Sciences
2378:Brandeis University faculty
2368:Princeton University alumni
1733:Nature Reviews Neuroscience
984:Petsko, Gregory A. (2008).
625:structure-based drug design
372:must be removed immediately
295:structure-based drug design
2424:
1696:10.1016/j.tins.2017.08.003
1348:10.1038/s41556-023-01245-2
946:Petsko Laboratory Homepage
1883:
1873:
1031:10.1186/gb-2010-11-10-138
596:National Medal of Science
280:National Medal of Science
213:
130:
28:
2373:American Rhodes Scholars
1085:10.1186/gb-2011-12-7-122
971:publications indexed by
2328:Mohammad Seyedsayamdost
2244:Wilfred A. van der Donk
1788:Nature Chemical Biology
1684:Trends in Neurosciences
1592:10.1126/science.adc9969
1421:10.1073/pnas.2212180120
642:. He is co-author with
636:protein crystallography
311:protein crystallography
818:University of Waterloo
588:Harvard Medical School
502:
456:Merton College, Oxford
366:Please help by adding
260:Harvard Medical School
208:David Chilton Phillips
142:Harvard Medical School
76:Merton College, Oxford
2214:David W. Christianson
2060:Michael J. Chamberlin
1800:10.1038/nchembio.1508
809:University of Toronto
789:, department head at
727:, department head at
671:X-ray crystallography
669:, in which they used
623:(especially by using
500:
361:references or sources
293:(especially by using
2232:Karin Musier-Forsyth
2048:Ekkehard K. F. Bautz
2002:Frederic M. Richards
1117:Brenner, S. (2002).
1014:"A Faustian bargain"
830:and now head of the
547:Dalhousie University
448:Princeton University
178:Princeton University
174:University of Oxford
170:Max Planck Institute
67:Princeton University
2094:Frederik C. Hartman
2082:Stephen J. Benkovic
2076:Joseph L. Goldstein
1978:Frank M. Huennekens
1954:G. Robert Greenberg
1924:Bernard L. Horecker
1900:Albert L. Lehninger
1584:2022Sci...377...31P
1413:2023PNAS..12012180J
1336:Nature Cell Biology
1293:1990Natur.347..631K
1246:2000Sci...287.1615S
1240:(5458): 1615–1622.
1191:1979Natur.280..558F
828:SGX Pharmaceuticals
782:Columbia University
760:Stanford University
736:, professor at the
572:Brandeis University
519:Brandeis University
276:Brandeis University
158:Brandeis University
113:Member of the U.S.
108:Member of the U.S.
2154:Kenneth A. Johnson
2112:Richard R. Burgess
1996:Marshall Nirenberg
1984:Jack L. Strominger
1407:(4): e2212180120.
1173:Frauenfelder, H.;
1068:"Food of the dogs"
973:Microsoft Academic
791:University of Iowa
762:and member of the
568:Cornell University
503:
452:Rhodes Scholarship
350:This section of a
272:Cornell University
238:and member of the
154:Cornell University
105:Rhodes Scholarship
2355:
2354:
2250:Nicole S. Sampson
2196:P. Andrew Karplus
2124:Robert T.N. Tjian
2066:Malcolm L. Gefter
2036:Herbert Weissbach
2030:Robert T. Schimke
2024:William J. Rutter
1960:Eugene P. Kennedy
1635:Stem Cell Reports
1342:(10): 1394–1397.
1287:(6294): 631–639.
1185:(5723): 558–563.
1162:. BioMed Central.
1119:"The worm's turn"
995:978-0-19-955684-7
832:Protein Data Bank
800:Boston University
687:molecular biology
621:discovering drugs
617:biochemical bases
444:
443:
436:
418:
291:discovering drugs
287:biochemical bases
232:Gregory A. Petsko
229:
228:
132:Scientific career
2415:
2334:Kenichi Yokoyama
2310:Douglas Mitchell
2274:Virginia Cornish
2262:Neil L. Kelleher
2208:Ronald T. Raines
2202:Daniel Herschlag
2148:John W. Kozarich
2100:Thomas A. Steitz
2072:Michael S. Brown
1930:Earl R. Stadtman
1860:
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1641:(3): 1046–1058.
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1301:10.1038/347631a0
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725:Ilme Schlichting
700:, professors at
675:protein dynamics
629:tested in humans
439:
432:
428:
425:
419:
417:
383:"Gregory Petsko"
376:
368:reliable sources
345:
344:
337:
307:tested in humans
225:
223:Official website
203:Doctoral advisor
197:
55:Washington, D.C.
51:
47:
45:
33:
19:
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2178:Michael H. Gelb
2118:Paul L. Mordich
2106:Daniel V. Santi
2054:Howard M. Temin
2008:Samuel B. Weiss
1990:Charles Gilvarg
1948:Merton F. Utter
1918:Arthur Kornberg
1879:
1869:
1864:
1834:
1833:
1781:
1780:
1776:
1745:10.1038/nrn3896
1726:
1725:
1721:
1690:(10): 592–602.
1677:
1676:
1672:
1628:
1627:
1623:
1578:(6601): 31–32.
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1123:Current Biology
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874:
869:
868:
867:
849:
845:
840:
816:, professor at
807:, professor at
787:Charles Brenner
780:, professor at
773:Yale University
771:, professor at
758:, professor at
656:Current Biology
613:
559:Laurie Glimcher
495:
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95:Laurie Glimcher
74:
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52:
49:
43:
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24:
17:
12:
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2316:Michelle Chang
2313:
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2286:Sarah O'Connor
2283:
2280:Vahe Bandarian
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2205:
2199:
2193:
2187:
2184:Donald Hilvert
2181:
2175:
2169:
2163:
2160:James A. Wells
2157:
2151:
2145:
2142:Gregory Petsko
2139:
2133:
2127:
2121:
2115:
2109:
2103:
2097:
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2085:
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2027:
2021:
2018:Salih J. Wakil
2014:P. Roy Vagelos
2011:
2005:
1999:
1993:
1987:
1981:
1975:
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1963:
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1933:
1927:
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1912:Britton Chance
1909:
1906:Henry A. Lardy
1903:
1897:
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1888:David E. Green
1884:
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1880:
1874:
1871:
1870:
1865:
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1855:
1848:
1840:
1832:
1831:
1794:(6): 443–449.
1774:
1739:(3): 126–132.
1719:
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1621:
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1387:
1322:
1267:
1220:
1165:
1150:
1109:
1072:Genome Biology
1055:
1018:Genome Biology
1001:
994:
976:
969:Gregory Petsko
961:
949:
935:
923:
911:
897:
871:
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862:Gregory Petsko
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