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in the human pancreas continue their maturation after birth. Arda and colleagues examined the gene expression and chromatin profiles of pancreas cells isolated from children and adults and found specific gene-expression programs that are turned on after the age of 10. The study was the first to
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in the human pancreas. She identified unique regions in our genomes that control cell-type-specific gene expression in human pancreas cells. These regions also turned out to harbor more disease-risk variants associated with diabetes or pancreas cancer than other parts of the
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To investigate genomic regulation, Arda continued to research the DNA elements that control pancreas-cell specification, identity, and function. Arda and co-authors and generated an atlas of genomic elements specific to the main
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Arda's laboratory aims to delineate the gene regulatory networks that control the development, expansion and function of human pancreatic cells. Her research group combines genomic approaches with use of primary
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Arda, H. Efsun; Li, Lingyu; Tsai, Jennifer; Torre, Eduardo A.; Rosli, Yenny; Peiris, Heshan; Spitale, Robert C.; Dai, Chunhua; Gu, Xueying; Qu, Kun; Wang, Pei (2016).
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Arda, H. Efsun; Tsai, Jennifer; Rosli, Yenny R.; Giresi, Paul; Bottino, Rita; Greenleaf, William J.; Chang, Howard Y.; Kim, Seung K. (2018).
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and genome-editing technologies to build maps of regulatory genomes governing the establishment and growth of human pancreatic
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demonstrate these differences at a global level, and the team uncovered new factors potentially mediating this process.
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to reveal hundreds of genes that are differentially regulated during the first 10 years of
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enhancer regions that explain cell type-specific gene expression in the human pancreas.
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programs are controlled at the genomic level, she then combined cell sorting with
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landscape of human pancreatic cell types. This work revealed thousands of
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This article incorporates text from this source, which is in the
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This article incorporates text from this source, which is in the
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in the laboratory of receptor biology and gene expression at the
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C. Elegans
Metabolic Gene Regulatory Networks: A Dissertation
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risk. To understand how pancreatic cell type-specific
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and head of the developmental genomics group at the
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240:Interested in gene regulatory networks and
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195:University of Massachusetts Medical School
65:University of Massachusetts Medical School
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308:In 2016, Arda's research showed that the
273:cells from children and adults, and used
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394:NIH Intramural Research Program
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390:"Getting to Know 11 Stadtmans"
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661:21st-century women scientists
631:National Institutes of Health
470:GSBS Dissertations and Theses
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607:H. Efsun Arda's publications
297:to delineate the regulatory
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711:Turkish systems scientists
691:Boğaziçi University alumni
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434:Center for Cancer Research
269:methods to purify primary
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224:. She uncovered a set of
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93:National Cancer Institute
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716:Women systems scientists
681:Developmental biologists
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595:publications indexed by
212:gene regulatory networks
174:Early life and education
154:that give rise to human
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615:(subscription required)
464:Arda, H. (2010-07-30).
218:of the model organism,
627:public domain material
431:"H. Efsun Arda, Ph.D."
364:single cell sequencing
340:principal investigator
338:in 2017 as a Stadtman
265:fellow, she developed
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160:single cell sequencing
242:developmental biology
236:Postdoctoral research
82:Developmental biology
214:that pertain to the
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330:Career and research
259:Stanford University
184:Boğaziçi University
60:Boğaziçi University
706:Systems biologists
676:Turkish biologists
478:10.13028/9v59-hc11
180:nurse practitioner
552:(3): 310–322.e4.
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399:2020-05-05
370:References
319:cell types
310:beta cells
271:pancreatic
230:C. elegans
221:C. elegans
216:metabolism
356:stem cell
299:chromatin
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303:putative
295:ATAC-Seq
283:diabetes
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291:genomic
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Text is available under the Creative Commons Attribution-ShareAlike License. Additional terms may apply.
