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Hyaluronan-mediated motility receptor

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1033:, RHAMM does not contain a membrane spanning domain nor does the mRNA transcript contain a signal sequence. RHAMM is localized inside the cell and is unconventionally exported to the cell surface in response to certain defined stimuli such as wounding and cytokines including TGF-β. The precise unconventional export mechanism for transporting RHAMM to the extracellular space is still unclear but may involve transport channels or proteins, flippase activity, or exocytosis, similar to other non-conventionally exported cell surface proteins such as BFGF1,2 and epimorphin. 244: 221: 118: 143: 495: 502: 250: 149: 1118:, it is likely just as important in this process and can act in concert with, or independently of CD44 to promote cell motility. Increased RHAMM expression is correlated with metastases in colorectal cancer, among others. Mechanistically, RHAMM has been shown to promote cell motility through a number of different pathways. As with CD44, RHAMM can promote 2834:
Pujana MA, Han JD, Starita LM, Stevens KN, Tewari M, Ahn JS, Rennert G, Moreno V, Kirchhoff T, Gold B, Assmann V, Elshamy WM, Rual JF, Levine D, Rozek LS, Gelman RS, Gunsalus KC, Greenberg RA, Sobhian B, Bertin N, Venkatesan K, Ayivi-Guedehoussou N, Solé X, Hernández P, Lázaro C, Nathanson KL, Weber
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Pujana MA, Han JD, Starita LM, Stevens KN, Tewari M, Ahn JS, Rennert G, Moreno V, Kirchhoff T, Gold B, Assmann V, Elshamy WM, Rual JF, Levine D, Rozek LS, Gelman RS, Gunsalus KC, Greenberg RA, Sobhian B, Bertin N, Venkatesan K, Ayivi-Guedehoussou N, Solé X, Hernández P, Lázaro C, Nathanson KL, Weber
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forms of RHAMM may be up regulated in some tumor types, promoting tumor progression. The presence of breast tumor cell subsets with high RHAMM expression is associated with reduced metastasis free survival and mediates migration, transformation, and metastatic spread of the triple negative human BCa
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Spicer AP, Roller ML, Camper SA, McPherson JD, Wasmuth JJ, Hakim S, Wang C, Turley EA, McDonald JA (Nov 1995). "The human and mouse receptors for hyaluronan-mediated motility, RHAMM, genes (HMMR) map to human chromosome 5q33.2-qter and mouse chromosome 11".
1048:, plays a role in the regulation of mitosis, and in maintaining mitotic spindle integrity. RHAMM also binds directly with ERK1 and forms complexes with ERK1,2 and MEK1, suggesting a role as a scaffold protein that targets these MAP kinases to the nucleus. 2384:
Pilarski LM, Pruski E, Wizniak J, Paine D, Seeberger K, Mant MJ, Brown CB, Belch AR (May 1999). "Potential role for hyaluronan and the hyaluronan receptor RHAMM in mobilization and trafficking of hematopoietic progenitor cells".
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Rein DT, Roehrig K, Schöndorf T, Lazar A, Fleisch M, Niederacher D, Bender HG, Dall P (Mar 2003). "Expression of the hyaluronan receptor RHAMM in endometrial carcinomas suggests a role in tumour progression and metastasis".
1739:"The overexpression of RHAMM, a hyaluronan-binding protein that regulates ras signaling, correlates with overexpression of mitogen-activated protein kinase and is a significant parameter in breast cancer progression" 2478:
Lynn BD, Li X, Cattini PA, Nagy JI (Jun 2001). "Sequence, protein expression and extracellular-regulated kinase association of the hyaladherin RHAMM (receptor for hyaluronan mediated motility) in PC12 cells".
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Akiyama Y, Jung S, Salhia B, Lee S, Hubbard S, Taylor M, Mainprize T, Akaishi K, van Furth W, Rutka JT (Jun 2001). "Hyaluronate receptors mediating glioma cell migration and proliferation".
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Yamasaki C, Tashiro S, Nishito Y, Sueda T, Igarashi K (Mar 2005). "Dynamic cytoplasmic anchoring of the transcription factor Bach1 by intracellular hyaluronic acid binding protein IHABP".
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Rizzardi AE, Vogel RI, Koopmeiners JS, Forster CL, Marston LO, Rosener NK, Akentieva N, Price MA, Metzger GJ, Warlick CA, Henriksen JC, Turley EA, McCarthy JB, Schmechel SC (Jun 2014).
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Rizzardi AE, Rosener NK, Koopmeiners JS, Isaksson Vogel R, Metzger GJ, Forster CL, Marston LO, Tiffany JR, McCarthy JB, Turley EA, Warlick CA, Henriksen JC, Schmechel SC (Apr 2014).
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Lynn BD, Turley EA, Nagy JI (Jul 2001). "Subcellular distribution, calmodulin interaction, and mitochondrial association of the hyaluronan-binding protein RHAMM in rat brain".
1697:"Overexpression of the receptor for hyaluronan-mediated motility (RHAMM) characterizes the malignant clone in multiple myeloma: identification of three distinct RHAMM variants" 2835:
BL, Cusick ME, Hill DE, Offit K, Livingston DM, Gruber SB, Parvin JD, Vidal M (Nov 2007). "Network modeling links breast cancer susceptibility and centrosome dysfunction".
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BL, Cusick ME, Hill DE, Offit K, Livingston DM, Gruber SB, Parvin JD, Vidal M (Nov 2007). "Network modeling links breast cancer susceptibility and centrosome dysfunction".
1929:"Hyaluronan-mediated motility receptor (RHAMM) immunohistochemical expression and androgen deprivation in normal peritumoral, hyperplasic and neoplastic prostate tissue" 2355:
Assmann V, Marshall JF, Fieber C, Hofmann M, Hart IR (Jun 1998). "The human hyaluronan receptor RHAMM is expressed as an intracellular protein in breast cancer cells".
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Assmann V, Jenkinson D, Marshall JF, Hart IR (Nov 1999). "The intracellular hyaluronan receptor RHAMM/IHABP interacts with microtubules and actin filaments".
1829:"Elevated hyaluronan and hyaluronan-mediated motility receptor are associated with biochemical failure in patients with intermediate-grade prostate tumors" 3765: 2902: 1147: 1025:. In contrast to CD44 and other cell-surface receptors which contain the classical membrane spanning domain and signal sequence for secretion from the 700: 681: 79: 4627: 2951: 2927: 2326:
Wang C, Entwistle J, Hou G, Li Q, Turley EA (Oct 1996). "The characterization of a human RHAMM cDNA: conservation of the hyaluronan-binding domains".
2555:"Differential involvement of the hyaluronan (HA) receptors CD44 and receptor for HA-mediated motility in endothelial cell function and angiogenesis" 2146:"Differential involvement of the hyaluronan (HA) receptors CD44 and receptor for HA-mediated motility in endothelial cell function and angiogenesis" 4358: 4346: 4124: 2627:"Receptor for hyaluronan acid-mediated motility (RHAMM) is a new immunogenic leukemia-associated antigen in acute and chronic myeloid leukemia" 4410: 4405: 4351: 2912: 1238: 1220: 4964: 4959: 3864: 3790: 2920: 1095:
are associated with the likelihood of undergoing biochemical failure in intermediate risk prostate cancer patients. RHAMM is also one of 3
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Greiner J, Ringhoffer M, Taniguchi M, Schmitt A, Kirchner D, Krähn G, Heilmann V, Gschwend J, Bergmann L, Döhner H, Schmitt M (Sep 2002).
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Li H, Guo L, Li J, Liu N, Liu J (Oct 2000). "Alternative splicing of RHAMM gene in chinese gastric cancers and its in vitro regulation".
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associated with aggressiveness in a multivariate analysis of human prostate tumors and elevated levels of RHAMM are associated with both
243: 4893: 4888: 4883: 4878: 3805: 2764:"Receptor for hyaluronan-mediated motility correlates with centrosome abnormalities in multiple myeloma and maintains mitotic integrity" 1550:"How does a protein with dual mitotic spindle and extracellular matrix receptor functions affect tumor susceptibility and progression?" 924: 1497:
Tolg C, Hamilton SR, Morningstar L, Zhang J, Zhang S, Esguerra KV, Telmer PG, Luyt LG, Harrison R, McCarthy JB, Turley EA (Aug 2010).
931: 220: 4858: 2445:"Differences in hyaluronic acid-mediated functions and signaling in arterial, microvessel, and vein-derived human endothelial cells" 2095:"The hyaluronan receptors CD44 and Rhamm (CD168) form complexes with ERK1,2 that sustain high basal motility in breast cancer cells" 2218:
Hall CL, Yang B, Yang X, Zhang S, Turley M, Samuel S, Lange LA, Wang C, Curpen GD, Savani RC, Greenberg AH, Turley EA (Jul 1995).
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Wang Z, Wu Y, Wang H, Zhang Y, Mei L, Fang X, Zhang X, Zhang F, Chen H, Liu Y, Jiang Y, Sun S, Zheng Y, Li N, Huang L (Jan 2014).
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Hamilton SR, Fard SF, Paiwand FF, Tolg C, Veiseh M, Wang C, McCarthy JB, Bissell MJ, Koropatnick J, Turley EA (Jun 2007).
1770:"Interplay of mevalonate and Hippo pathways regulates RHAMM transcription via YAP to modulate breast cancer cell motility" 1151: 1072: 1182: 1107:
disease. RHAMM has also been identified as one of 4 gene products identified in circulating tumor cells in patients with
4492: 4215: 1100: 1055:, activates intracellular signaling pathways, mainly the MAPK pathway via ERK1,2 activation Variants of RHAMM caused by 59: 1134:. RHAMM also activates a number of downstream kinases including enhancing the intensity and sustaining the duration of 3810: 2046:"Hyaluronan and the hyaluronan receptor RHAMM promote focal adhesion turnover and transient tyrosine kinase activity" 256: 155: 4522: 2947: 1273:
Turley EA (Oct 1982). "Purification of a hyaluronate-binding protein fraction that modifies cell social behavior".
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have been observed, and alternative start codon usage has been proposed in mice and directly observed in humans.
249: 148: 4572: 3467: 2220:"Overexpression of the hyaluronan receptor RHAMM is transforming and is also required for H-ras transformation" 745: 67: 1599:"Hyaluronan and a cell-associated hyaluronan binding protein regulate the locomotion of ras-transformed cells" 1499:"RHAMM promotes interphase microtubule instability and mitotic spindle integrity through MEK1/ERK1/2 activity" 4536: 1646:
Rhodes DR, Yu J, Shanker K, Deshpande N, Varambally R, Ghosh D, Barrette T, Pandey A, Chinnaiyan AM (2004).
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Hardwick C, Hoare K, Owens R, Hohn HP, Hook M, Moore D, Cripps V, Austen L, Nance DM, Turley EA (Jun 1992).
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Zhonghua Yi Xue Yi Chuan Xue Za Zhi = Zhonghua Yixue Yichuanxue Zazhi = Chinese Journal of Medical Genetics
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Dawson SJ, White LA (May 1992). "Treatment of Haemophilus aphrophilus endocarditis with ciprofloxacin".
1154:(ROK). Finally, once a metastatic lesion has been established, RHAMM can cooperate with CD44 to promote 1123: 1080: 1026: 1409:
Joukov V, Groen AC, Prokhorova T, Gerson R, White E, Rodriguez A, Walter JC, Livingston DM (Nov 2006).
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RHAMM was originally discovered as a soluble protein that altered migratory cell behavior and bound to
2866:"Hyaluronan-mediated motility receptor gene single nucleotide polymorphisms and risk of breast cancer" 1696: 1360:
Maxwell CA, Keats JJ, Crainie M, Sun X, Yen T, Shibuya E, Hendzel M, Chan G, Pilarski LM (June 2003).
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Maxwell CA, Keats JJ, Crainie M, Sun X, Yen T, Shibuya E, Hendzel M, Chan G, Pilarski LM (Jun 2003).
2263:"Regulated expression of a receptor for hyaluronan-mediated motility on human thymocytes and T cells" 1781: 1056: 131: 46: 4487: 4306: 1108: 878: 874: 823: 819: 50:, CD168, IHABP, RHAMM, Hyaluronan-mediated motility receptor, hyaluronan mediated motility receptor 3894: 3628: 2793: 2686: 2613: 2541: 2504: 2249: 1958: 1440: 91: 2700:"RHAMM is a centrosomal protein that interacts with dynein and maintains spindle pole stability" 1927:
Korkes F, de Castro MG, de Cassio Zequi S, Nardi L, Del Giglio A, de Lima Pompeo AC (May 2014).
1362:"RHAMM is a centrosomal protein that interacts with dynein and maintains spindle pole stability" 907: 886: 882: 848: 827: 815: 2887: 2852: 2822: 2785: 2750: 2729: 2678: 2648: 2605: 2576: 2533: 2496: 2466: 2431: 2402: 2372: 2343: 2314: 2284: 2241: 2206: 2167: 2126: 2075: 2026: 1999: 1950: 1909: 1858: 1809: 1750: 1719: 1677: 1628: 1579: 1530: 1476: 1432: 1391: 1339: 1290: 1159: 1115: 39: 1738: 4667: 4400: 4321: 3884: 3077: 3003: 2877: 2844: 2814: 2775: 2719: 2711: 2670: 2638: 2597: 2566: 2525: 2488: 2456: 2423: 2394: 2364: 2335: 2306: 2274: 2231: 2198: 2157: 2116: 2106: 2065: 2057: 1989: 1940: 1899: 1889: 1848: 1840: 1799: 1789: 1711: 1667: 1659: 1618: 1610: 1569: 1561: 1520: 1510: 1468: 1422: 1381: 1373: 1329: 1321: 1282: 494: 336: 267: 211: 166: 1737:
Wang C, Thor AD, Moore DH, Zhao Y, Kerschmann R, Stern R, Watson PH, Turley EA (Mar 1998).
4727: 3263: 3258: 3181: 1978:"Newly identified biomarkers for detecting circulating tumor cells in lung adenocarcinoma" 1127: 1104: 501: 311: 87: 2741:
Aziz KA (Aug 2003). "CD44 mediates polymorphonuclear leukocyte motility on hyaluronan".
1785: 4512: 3934: 3445: 3248: 2121: 2094: 2070: 2045: 1904: 1877: 1853: 1828: 1804: 1769: 1672: 1647: 1623: 1598: 1574: 1549: 1525: 1498: 1334: 1309: 1119: 2724: 2699: 2643: 2626: 2492: 2202: 1663: 1386: 1361: 615: 610: 594: 589: 584: 579: 574: 569: 564: 548: 543: 4953: 4482: 3939: 3030: 2906: 2339: 2236: 2219: 1286: 1068: 1030: 530: 2797: 2690: 2617: 2545: 2508: 2253: 1444: 1310:"Molecular cloning of a novel hyaluronan receptor that mediates tumor cell motility" 4838: 4146: 4136: 3667: 3633: 1962: 1155: 1037: 329: 108: 71: 2882: 2865: 2279: 2262: 95: 4848: 4497: 4275: 4250: 3949: 3571: 3497: 2971: 1243:
National Center for Biotechnology Information, U.S. National Library of Medicine
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National Center for Biotechnology Information, U.S. National Library of Medicine
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Proceedings of the National Academy of Sciences of the United States of America
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Man Y, Cao J, Jin S, Xu G, Pan B, Shang L, Che D, Yu Q, Yu Y (Sep 2014).
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Kalmyrzaev B, Pharoah PD, Easton DF, Ponder BA, Dunning AM (Dec 2008).
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Savani RC, Cao G, Pooler PM, Zaman A, Zhou Z, DeLisser HM (Sep 2001).
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Savani RC, Cao G, Pooler PM, Zaman A, Zhou Z, DeLisser HM (Sep 2001).
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Maxwell CA, Keats JJ, Belch AR, Pilarski LM, Reiman T (Feb 2005).
1139: 1135: 1045: 1041: 1260:"Entrez Gene: HMMR hyaluronan-mediated motility receptor (RHAMM)" 1051:
Extracellularly, RHAMM associates with CD44, and upon binding to
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While RHAMM has been less studied than CD44 in the process of
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Crainie M, Belch AR, Mant MJ, Pilarski LM (Mar 1999).
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Turley EA, Austen L, Vandeligt K, Clary C (Mar 1991).
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Telmer PG, Tolg C, McCarthy JB, Turley EA (Mar 2011).
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Biochemical and Biophysical Research Communications
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regulation of G2/M transition of mitotic cell cycle
1199: 1197: 1195: 1178: 1176: 1174: 2044:Hall CL, Wang C, Lange LA, Turley EA (Jul 1994). 988:RHAMM (Receptor for Hyaluronan Mediated Motility) 266: 165: 2870:Cancer Epidemiology, Biomarkers & Prevention 2663:Journal of Cancer Research and Clinical Oncology 1492: 1490: 18:Protein-coding gene in the species Homo sapiens 1355: 1353: 1204:GRCm38: Ensembl release 89: ENSMUSG00000020330 2928: 2261:Pilarski LM, Miszta H, Turley EA (May 1993). 8: 984:Hyaluronan-mediated motility receptor (HMMR) 1982:The Tohoku Journal of Experimental Medicine 1183:GRCh38: Ensembl release 89: ENSG00000072571 2935: 2921: 2913: 2903:United States National Library of Medicine 1079:subtypes is associated with poor outcome. 1001:. RHAMM recently has been also designated 641: 526: 307: 206: 103: 2952:list of human clusters of differentiation 2881: 2779: 2723: 2642: 2570: 2460: 2278: 2235: 2161: 2120: 2110: 2069: 1993: 1944: 1903: 1893: 1852: 1803: 1793: 1671: 1622: 1573: 1524: 1514: 1426: 1385: 1333: 2901:This article incorporates text from the 1254: 1252: 1554:Communicative & Integrative Biology 1170: 1130:and cooperating with the α4β1 and α5β1 1036:Intracellularly, RHAMM associates with 1158:by promoting migration of neighboring 20: 271: 232: 227: 170: 129: 124: 7: 2443:Lokeshwar VB, Selzer MG (Sep 2000). 455:endothelial cell of lymphatic vessel 2559:The Journal of Biological Chemistry 2449:The Journal of Biological Chemistry 2150:The Journal of Biological Chemistry 2099:The Journal of Biological Chemistry 1503:The Journal of Biological Chemistry 994:which in humans is encoded by the 897: 864: 838: 805: 781: 762: 736: 717: 691: 672: 489: 407: 345: 324: 14: 1150:), and the downstream targets of 2518:Journal of Neuroscience Research 500: 493: 255: 248: 242: 219: 154: 147: 141: 116: 511:More reference expression data 473:More reference expression data 1: 2883:10.1158/1055-9965.EPI-08-0216 2704:Molecular Biology of the Cell 2644:10.1016/S0301-472X(02)00874-3 2493:10.1016/S0304-3940(01)01870-5 2203:10.1016/S0163-4453(05)80037-4 1664:10.1016/S1476-5586(04)80047-2 1366:Molecular Biology of the Cell 1091:Elevated levels of RHAMM and 240: 139: 2340:10.1016/0378-1119(96)00080-7 2280:10.4049/jimmunol.150.10.4292 2237:10.1016/0092-8674(95)90048-9 1287:10.1016/0006-291X(82)92101-5 1101:androgen deprivation therapy 611:hyaluronan catabolic process 4965:Clusters of differentiation 4960:Genes on human chromosome 5 2948:clusters of differentiation 2050:The Journal of Cell Biology 1603:The Journal of Cell Biology 1314:The Journal of Cell Biology 1067:RHAMM is over expressed in 4981: 2781:10.1158/0008-5472.850.65.3 1428:10.1016/j.cell.2006.08.053 1007:cluster of differentiation 2675:10.1007/s00432-003-0415-0 2590:Journal of Neuro-Oncology 1239:"Mouse PubMed Reference:" 1221:"Human PubMed Reference:" 970: 965: 961: 954: 938: 925:Chr 5: 163.46 – 163.49 Mb 919: 904: 871: 860: 845: 812: 801: 788: 784: 769: 765: 756: 743: 739: 724: 720: 711: 698: 694: 679: 675: 666: 651: 644: 640: 624: 529: 525: 508: 492: 483: 470: 459:atrioventricular junction 419: 410: 357: 348: 318: 310: 306: 289: 276: 239: 218: 209: 205: 188: 175: 138: 115: 106: 102: 57: 54: 44: 37: 32: 28: 23: 2399:10.1182/blood.V93.9.2918 2191:The Journal of Infection 1895:10.1186/1471-2407-14-244 1743:Clinical Cancer Research 1716:10.1182/blood.V93.5.1684 1122:turnover by controlling 932:Chr 11: 40.59 – 40.62 Mb 595:microtubule cytoskeleton 2807:Journal of Biochemistry 2716:10.1091/mbc.E02-07-0377 2631:Experimental Hematology 2602:10.1023/A:1012297132047 2428:10.1242/jcs.112.22.3943 2416:Journal of Cell Science 2369:10.1242/jcs.111.12.1685 2357:Journal of Cell Science 1795:10.1073/pnas.1319190110 1516:10.1074/jbc.M110.121491 1378:10.1091/mbc.E02-07-0377 1142:activation through the 549:hyaluronic acid binding 2572:10.1074/jbc.M102273200 2462:10.1074/jbc.M003084200 2311:10.1006/geno.1995.0022 2163:10.1074/jbc.M102273200 2112:10.1074/jbc.M702078200 1615:10.1083/jcb.112.5.1041 1326:10.1083/jcb.117.6.1343 1146:(MAPK) pathway, pp60 ( 1071:and its expression in 439:lumbar spinal ganglion 2743:Saudi Medical Journal 2267:Journal of Immunology 2062:10.1083/jcb.126.2.575 1566:10.4161/cib.4.2.14270 1124:focal adhesion kinase 1081:Alternatively spliced 1063:Clinical significance 1027:endoplasmic reticulum 273:11 A5|11 24.4 cM 234:Chromosome 11 (mouse) 2481:Neuroscience Letters 1105:castration resistant 1057:alternative splicing 451:maxillary prominence 132:Chromosome 5 (human) 2565:(39): 36770–36778. 2455:(36): 27641–27649. 2156:(39): 36770–36778. 2105:(22): 16667–16680. 1995:10.1620/tjem.234.29 1786:2014PNAS..111E..89W 1509:(34): 26461–26474. 1162:towards the tumor. 1109:lung adenocarcinoma 2905:, which is in the 1845:10.1002/cncr.28646 1040:and, working with 746:ENSMUSG00000020330 604:Biological process 558:Cellular component 537:Molecular function 4947: 4946: 2876:(12): 3618–3620. 2849:10.1038/ng.2007.2 2843:(11): 1338–1349. 2819:10.1093/jb/mvi031 2422:(22): 3943–3954. 2363:(12): 1685–1694. 2273:(10): 4292–4302. 1946:10.1111/bju.12339 1933:BJU International 1839:(12): 1800–1809. 1473:10.1038/ng.2007.2 1467:(11): 1338–1349. 1160:endothelial cells 1116:cancer metastasis 981: 980: 977: 976: 950: 949: 915: 914: 894: 893: 856: 855: 835: 834: 797: 796: 778: 777: 752: 751: 733: 732: 707: 706: 688: 687: 636: 635: 521: 520: 517: 516: 479: 478: 466: 465: 404: 403: 393:bone marrow cells 302: 301: 201: 200: 4972: 2937: 2930: 2923: 2914: 2895: 2885: 2860: 2830: 2801: 2783: 2758: 2737: 2727: 2710:(6): 2262–2276. 2694: 2656: 2646: 2637:(9): 1029–1035. 2621: 2584: 2574: 2549: 2530:10.1002/jnr.1122 2512: 2474: 2464: 2439: 2410: 2393:(9): 2918–2927. 2380: 2351: 2322: 2292: 2282: 2257: 2239: 2214: 2176: 2175: 2165: 2141: 2135: 2134: 2124: 2114: 2090: 2084: 2083: 2073: 2041: 2035: 2034: 2014: 2008: 2007: 1997: 1973: 1967: 1966: 1948: 1924: 1918: 1917: 1907: 1897: 1873: 1867: 1866: 1856: 1824: 1818: 1817: 1807: 1797: 1765: 1759: 1758: 1734: 1728: 1727: 1710:(5): 1684–1696. 1701: 1692: 1686: 1685: 1675: 1643: 1637: 1636: 1626: 1609:(5): 1041–1047. 1594: 1588: 1587: 1577: 1545: 1539: 1538: 1528: 1518: 1494: 1485: 1484: 1455: 1449: 1448: 1430: 1406: 1400: 1399: 1389: 1372:(6): 2262–2276. 1357: 1348: 1347: 1337: 1320:(6): 1343–1350. 1305: 1299: 1298: 1281:(3): 1016–1024. 1270: 1264: 1263: 1256: 1247: 1246: 1235: 1229: 1228: 1217: 1211: 1201: 1190: 1180: 986:, also known as 963: 962: 934: 927: 910: 898: 889: 865: 861:RefSeq (protein) 851: 839: 830: 806: 782: 763: 737: 718: 692: 673: 642: 527: 513: 504: 497: 490: 475: 431:genital tubercle 415: 413:Top expressed in 408: 385:ventricular zone 377:secondary oocyte 353: 351:Top expressed in 346: 325: 308: 298: 285: 274: 259: 252: 246: 235: 223: 207: 197: 184: 173: 158: 151: 145: 134: 120: 104: 98: 96:HMMR - orthologs 49: 42: 21: 4980: 4979: 4975: 4974: 4973: 4971: 4970: 4969: 4950: 4949: 4948: 4943: 4747: 4541: 4290: 3974: 3697: 3357: 2955: 2941: 2898: 2863: 2837:Nature Genetics 2833: 2804: 2768:Cancer Research 2761: 2740: 2697: 2659: 2624: 2587: 2552: 2515: 2477: 2442: 2413: 2383: 2354: 2325: 2295: 2260: 2217: 2188: 2184: 2182:Further reading 2179: 2143: 2142: 2138: 2092: 2091: 2087: 2043: 2042: 2038: 2016: 2015: 2011: 1975: 1974: 1970: 1926: 1925: 1921: 1875: 1874: 1870: 1826: 1825: 1821: 1767: 1766: 1762: 1736: 1735: 1731: 1699: 1694: 1693: 1689: 1645: 1644: 1640: 1596: 1595: 1591: 1547: 1546: 1542: 1496: 1495: 1488: 1461:Nature Genetics 1457: 1456: 1452: 1408: 1407: 1403: 1359: 1358: 1351: 1307: 1306: 1302: 1272: 1271: 1267: 1258: 1257: 1250: 1237: 1236: 1232: 1219: 1218: 1214: 1202: 1193: 1181: 1172: 1168: 1128:phosphorylation 1073:triple negative 1065: 1015: 972:View/Edit Mouse 967:View/Edit Human 930: 923: 920:Location (UCSC) 906: 885: 881: 877: 873: 847: 826: 822: 818: 814: 727:ENSG00000072571 620: 599: 575:plasma membrane 553: 544:protein binding 509: 499: 498: 471: 462: 457: 453: 449: 445: 441: 437: 433: 429: 425: 411: 400: 395: 391: 387: 383: 379: 375: 371: 367: 365:trabecular bone 363: 349: 293: 280: 272: 262: 261: 260: 253: 233: 210:Gene location ( 192: 179: 171: 161: 160: 159: 152: 130: 107:Gene location ( 58: 45: 38: 19: 12: 11: 5: 4978: 4976: 4968: 4967: 4962: 4952: 4951: 4945: 4944: 4942: 4941: 4936: 4931: 4926: 4921: 4916: 4911: 4906: 4901: 4896: 4891: 4886: 4881: 4876: 4871: 4866: 4861: 4856: 4851: 4846: 4841: 4836: 4831: 4826: 4821: 4816: 4811: 4806: 4801: 4796: 4791: 4786: 4781: 4776: 4771: 4766: 4761: 4755: 4753: 4749: 4748: 4746: 4745: 4740: 4735: 4730: 4725: 4720: 4715: 4710: 4705: 4700: 4695: 4690: 4685: 4680: 4675: 4670: 4665: 4660: 4655: 4650: 4645: 4640: 4635: 4630: 4625: 4620: 4615: 4610: 4605: 4600: 4595: 4590: 4585: 4580: 4575: 4570: 4565: 4560: 4555: 4549: 4547: 4543: 4542: 4540: 4539: 4534: 4525: 4520: 4515: 4510: 4505: 4500: 4495: 4490: 4485: 4480: 4479: 4478: 4473: 4463: 4458: 4453: 4448: 4443: 4438: 4433: 4428: 4423: 4418: 4413: 4408: 4403: 4398: 4392: 4383: 4378: 4377: 4376: 4371: 4361: 4356: 4355: 4354: 4349: 4339: 4334: 4329: 4324: 4319: 4314: 4309: 4304: 4298: 4296: 4292: 4291: 4289: 4288: 4283: 4278: 4273: 4268: 4263: 4258: 4253: 4248: 4243: 4238: 4233: 4228: 4223: 4218: 4213: 4208: 4203: 4202: 4201: 4196: 4186: 4181: 4176: 4171: 4170: 4169: 4164: 4159: 4149: 4144: 4139: 4134: 4129: 4128: 4127: 4122: 4112: 4107: 4102: 4097: 4092: 4087: 4082: 4081: 4080: 4075: 4065: 4059: 4054: 4049: 4044: 4035: 4030: 4029: 4028: 4023: 4018: 4008: 4003: 3998: 3993: 3988: 3982: 3980: 3976: 3975: 3973: 3972: 3967: 3962: 3957: 3952: 3947: 3942: 3937: 3932: 3927: 3922: 3917: 3912: 3907: 3902: 3897: 3892: 3887: 3882: 3877: 3872: 3867: 3862: 3857: 3852: 3847: 3846: 3845: 3840: 3830: 3829: 3828: 3823: 3813: 3808: 3803: 3798: 3793: 3788: 3783: 3778: 3773: 3768: 3763: 3758: 3753: 3752: 3751: 3746: 3736: 3731: 3726: 3721: 3716: 3711: 3705: 3703: 3699: 3698: 3696: 3695: 3690: 3685: 3680: 3675: 3670: 3665: 3660: 3655: 3646: 3641: 3636: 3631: 3626: 3621: 3620: 3619: 3614: 3609: 3604: 3599: 3594: 3584: 3579: 3574: 3569: 3564: 3559: 3558: 3557: 3552: 3542: 3537: 3532: 3527: 3522: 3517: 3512: 3507: 3502: 3501: 3500: 3495: 3490: 3485: 3480: 3475: 3465: 3464: 3463: 3458: 3453: 3443: 3438: 3437: 3436: 3431: 3426: 3416: 3411: 3406: 3401: 3396: 3391: 3386: 3381: 3376: 3371: 3365: 3363: 3359: 3358: 3356: 3355: 3350: 3349: 3348: 3343: 3338: 3333: 3328: 3323: 3313: 3308: 3303: 3298: 3293: 3288: 3283: 3282: 3281: 3276: 3271: 3266: 3256: 3251: 3246: 3241: 3236: 3231: 3226: 3221: 3216: 3211: 3210: 3209: 3204: 3194: 3189: 3184: 3179: 3174: 3169: 3164: 3159: 3154: 3149: 3144: 3139: 3134: 3129: 3124: 3123: 3122: 3117: 3107: 3102: 3097: 3092: 3091: 3090: 3085: 3080: 3075: 3065: 3060: 3055: 3054: 3053: 3043: 3038: 3033: 3028: 3023: 3022: 3021: 3016: 3011: 3001: 2996: 2995: 2994: 2989: 2984: 2979: 2974: 2963: 2961: 2957: 2956: 2942: 2940: 2939: 2932: 2925: 2917: 2897: 2896: 2861: 2831: 2813:(3): 287–296. 2802: 2774:(3): 850–860. 2759: 2749:(8): 827–831. 2738: 2695: 2669:(3): 161–164. 2657: 2622: 2596:(2): 115–127. 2585: 2550: 2513: 2487:(1–2): 49–52. 2475: 2440: 2411: 2381: 2352: 2334:(2): 299–306. 2323: 2305:(1): 115–117. 2293: 2258: 2215: 2197:(3): 317–320. 2185: 2183: 2180: 2178: 2177: 2136: 2085: 2056:(2): 575–588. 2036: 2025:(5): 343–347. 2021:(in Chinese). 2009: 1968: 1939:(5): 822–829. 1919: 1868: 1819: 1780:(1): E89–E98. 1760: 1749:(3): 567–576. 1729: 1687: 1638: 1589: 1560:(2): 182–185. 1540: 1486: 1450: 1421:(3): 539–552. 1401: 1349: 1300: 1265: 1248: 1230: 1212: 1191: 1169: 1167: 1164: 1120:focal adhesion 1064: 1061: 1014: 1011: 979: 978: 975: 974: 969: 959: 958: 952: 951: 948: 947: 945: 943: 936: 935: 928: 921: 917: 916: 913: 912: 902: 901: 895: 892: 891: 869: 868: 862: 858: 857: 854: 853: 843: 842: 836: 833: 832: 810: 809: 803: 799: 798: 795: 794: 786: 785: 779: 776: 775: 767: 766: 760: 754: 753: 750: 749: 741: 740: 734: 731: 730: 722: 721: 715: 709: 708: 705: 704: 696: 695: 689: 686: 685: 677: 676: 670: 664: 663: 658: 653: 649: 648: 638: 637: 634: 633: 622: 621: 619: 618: 613: 607: 605: 601: 600: 598: 597: 592: 587: 582: 577: 572: 567: 561: 559: 555: 554: 552: 551: 546: 540: 538: 534: 533: 523: 522: 519: 518: 515: 514: 506: 505: 487: 481: 480: 477: 476: 468: 467: 464: 463: 461: 460: 456: 452: 448: 444: 440: 436: 435:tail of embryo 432: 428: 424: 420: 417: 416: 405: 402: 401: 399: 398: 394: 390: 386: 382: 378: 374: 370: 366: 362: 358: 355: 354: 342: 341: 333: 322: 316: 315: 312:RNA expression 304: 303: 300: 299: 291: 287: 286: 278: 275: 270: 264: 263: 254: 247: 241: 237: 236: 231: 225: 224: 216: 215: 203: 202: 199: 198: 190: 186: 185: 177: 174: 169: 163: 162: 153: 146: 140: 136: 135: 128: 122: 121: 113: 112: 100: 99: 56: 52: 51: 43: 35: 34: 30: 29: 26: 25: 17: 13: 10: 9: 6: 4: 3: 2: 4977: 4966: 4963: 4961: 4958: 4957: 4955: 4940: 4937: 4935: 4932: 4930: 4927: 4925: 4922: 4920: 4917: 4915: 4912: 4910: 4907: 4905: 4902: 4900: 4897: 4895: 4892: 4890: 4887: 4885: 4882: 4880: 4877: 4875: 4872: 4870: 4867: 4865: 4862: 4860: 4857: 4855: 4852: 4850: 4847: 4845: 4842: 4840: 4837: 4835: 4832: 4830: 4827: 4825: 4822: 4820: 4817: 4815: 4812: 4810: 4807: 4805: 4802: 4800: 4797: 4795: 4792: 4790: 4787: 4785: 4782: 4780: 4777: 4775: 4772: 4770: 4767: 4765: 4762: 4760: 4757: 4756: 4754: 4750: 4744: 4741: 4739: 4736: 4734: 4731: 4729: 4726: 4724: 4721: 4719: 4716: 4714: 4711: 4709: 4706: 4704: 4701: 4699: 4696: 4694: 4691: 4689: 4686: 4684: 4681: 4679: 4676: 4674: 4671: 4669: 4666: 4664: 4661: 4659: 4656: 4654: 4651: 4649: 4646: 4644: 4641: 4639: 4636: 4634: 4631: 4629: 4626: 4624: 4621: 4619: 4616: 4614: 4611: 4609: 4606: 4604: 4601: 4599: 4596: 4594: 4591: 4589: 4586: 4584: 4581: 4579: 4576: 4574: 4571: 4569: 4566: 4564: 4561: 4559: 4556: 4554: 4551: 4550: 4548: 4544: 4538: 4535: 4533: 4529: 4526: 4524: 4521: 4519: 4516: 4514: 4511: 4509: 4506: 4504: 4501: 4499: 4496: 4494: 4491: 4489: 4486: 4484: 4481: 4477: 4474: 4472: 4469: 4468: 4467: 4464: 4462: 4459: 4457: 4454: 4452: 4449: 4447: 4444: 4442: 4439: 4437: 4434: 4432: 4429: 4427: 4424: 4422: 4419: 4417: 4414: 4412: 4409: 4407: 4404: 4402: 4399: 4396: 4393: 4391: 4387: 4384: 4382: 4379: 4375: 4372: 4370: 4367: 4366: 4365: 4362: 4360: 4357: 4353: 4350: 4348: 4345: 4344: 4343: 4340: 4338: 4335: 4333: 4330: 4328: 4325: 4323: 4320: 4318: 4315: 4313: 4310: 4308: 4305: 4303: 4300: 4299: 4297: 4293: 4287: 4284: 4282: 4279: 4277: 4274: 4272: 4269: 4267: 4264: 4262: 4259: 4257: 4254: 4252: 4249: 4247: 4244: 4242: 4239: 4237: 4234: 4232: 4229: 4227: 4224: 4222: 4219: 4217: 4214: 4212: 4209: 4207: 4204: 4200: 4197: 4195: 4192: 4191: 4190: 4187: 4185: 4182: 4180: 4177: 4175: 4172: 4168: 4165: 4163: 4160: 4158: 4155: 4154: 4153: 4150: 4148: 4145: 4143: 4140: 4138: 4135: 4133: 4130: 4126: 4123: 4121: 4118: 4117: 4116: 4113: 4111: 4108: 4106: 4103: 4101: 4098: 4096: 4093: 4091: 4088: 4086: 4083: 4079: 4076: 4074: 4071: 4070: 4069: 4066: 4063: 4060: 4058: 4055: 4053: 4050: 4048: 4045: 4043: 4039: 4036: 4034: 4031: 4027: 4024: 4022: 4019: 4017: 4014: 4013: 4012: 4009: 4007: 4004: 4002: 3999: 3997: 3994: 3992: 3989: 3987: 3984: 3983: 3981: 3977: 3971: 3968: 3966: 3963: 3961: 3958: 3956: 3953: 3951: 3948: 3946: 3943: 3941: 3938: 3936: 3933: 3931: 3928: 3926: 3923: 3921: 3918: 3916: 3913: 3911: 3908: 3906: 3903: 3901: 3898: 3896: 3893: 3891: 3888: 3886: 3883: 3881: 3878: 3876: 3873: 3871: 3868: 3866: 3863: 3861: 3858: 3856: 3853: 3851: 3848: 3844: 3841: 3839: 3836: 3835: 3834: 3831: 3827: 3824: 3822: 3819: 3818: 3817: 3814: 3812: 3809: 3807: 3804: 3802: 3799: 3797: 3794: 3792: 3789: 3787: 3784: 3782: 3779: 3777: 3774: 3772: 3769: 3767: 3764: 3762: 3759: 3757: 3754: 3750: 3747: 3745: 3742: 3741: 3740: 3737: 3735: 3732: 3730: 3727: 3725: 3722: 3720: 3717: 3715: 3712: 3710: 3707: 3706: 3704: 3700: 3694: 3691: 3689: 3686: 3684: 3681: 3679: 3676: 3674: 3671: 3669: 3666: 3664: 3661: 3659: 3656: 3654: 3650: 3647: 3645: 3642: 3640: 3637: 3635: 3632: 3630: 3627: 3625: 3622: 3618: 3615: 3613: 3610: 3608: 3605: 3603: 3600: 3598: 3595: 3593: 3590: 3589: 3588: 3585: 3583: 3580: 3578: 3575: 3573: 3570: 3568: 3565: 3563: 3560: 3556: 3553: 3551: 3548: 3547: 3546: 3543: 3541: 3538: 3536: 3533: 3531: 3528: 3526: 3523: 3521: 3518: 3516: 3513: 3511: 3508: 3506: 3503: 3499: 3496: 3494: 3491: 3489: 3486: 3484: 3481: 3479: 3476: 3474: 3471: 3470: 3469: 3466: 3462: 3459: 3457: 3454: 3452: 3449: 3448: 3447: 3444: 3442: 3439: 3435: 3432: 3430: 3427: 3425: 3422: 3421: 3420: 3417: 3415: 3412: 3410: 3407: 3405: 3402: 3400: 3397: 3395: 3392: 3390: 3387: 3385: 3382: 3380: 3377: 3375: 3372: 3370: 3367: 3366: 3364: 3360: 3354: 3351: 3347: 3344: 3342: 3339: 3337: 3334: 3332: 3329: 3327: 3324: 3322: 3319: 3318: 3317: 3314: 3312: 3309: 3307: 3304: 3302: 3299: 3297: 3294: 3292: 3289: 3287: 3284: 3280: 3277: 3275: 3272: 3270: 3267: 3265: 3262: 3261: 3260: 3257: 3255: 3252: 3250: 3247: 3245: 3242: 3240: 3237: 3235: 3232: 3230: 3227: 3225: 3222: 3220: 3217: 3215: 3212: 3208: 3205: 3203: 3200: 3199: 3198: 3195: 3193: 3190: 3188: 3185: 3183: 3180: 3178: 3175: 3173: 3170: 3168: 3165: 3163: 3160: 3158: 3155: 3153: 3150: 3148: 3145: 3143: 3140: 3138: 3135: 3133: 3130: 3128: 3125: 3121: 3118: 3116: 3113: 3112: 3111: 3108: 3106: 3103: 3101: 3098: 3096: 3093: 3089: 3086: 3084: 3081: 3079: 3076: 3074: 3071: 3070: 3069: 3066: 3064: 3061: 3059: 3056: 3052: 3049: 3048: 3047: 3044: 3042: 3039: 3037: 3034: 3032: 3029: 3027: 3024: 3020: 3017: 3015: 3012: 3010: 3007: 3006: 3005: 3002: 3000: 2997: 2993: 2990: 2988: 2985: 2983: 2980: 2978: 2975: 2973: 2970: 2969: 2968: 2965: 2964: 2962: 2958: 2953: 2949: 2945: 2938: 2933: 2931: 2926: 2924: 2919: 2918: 2915: 2911: 2910: 2908: 2907:public domain 2904: 2893: 2889: 2884: 2879: 2875: 2871: 2867: 2862: 2858: 2854: 2850: 2846: 2842: 2838: 2832: 2828: 2824: 2820: 2816: 2812: 2808: 2803: 2799: 2795: 2791: 2787: 2782: 2777: 2773: 2769: 2765: 2760: 2756: 2752: 2748: 2744: 2739: 2735: 2731: 2726: 2721: 2717: 2713: 2709: 2705: 2701: 2696: 2692: 2688: 2684: 2680: 2676: 2672: 2668: 2664: 2658: 2654: 2650: 2645: 2640: 2636: 2632: 2628: 2623: 2619: 2615: 2611: 2607: 2603: 2599: 2595: 2591: 2586: 2582: 2578: 2573: 2568: 2564: 2560: 2556: 2551: 2547: 2543: 2539: 2535: 2531: 2527: 2523: 2519: 2514: 2510: 2506: 2502: 2498: 2494: 2490: 2486: 2482: 2476: 2472: 2468: 2463: 2458: 2454: 2450: 2446: 2441: 2437: 2433: 2429: 2425: 2421: 2417: 2412: 2408: 2404: 2400: 2396: 2392: 2388: 2382: 2378: 2374: 2370: 2366: 2362: 2358: 2353: 2349: 2345: 2341: 2337: 2333: 2329: 2324: 2320: 2316: 2312: 2308: 2304: 2300: 2294: 2290: 2286: 2281: 2276: 2272: 2268: 2264: 2259: 2255: 2251: 2247: 2243: 2238: 2233: 2229: 2225: 2221: 2216: 2212: 2208: 2204: 2200: 2196: 2192: 2187: 2186: 2181: 2173: 2169: 2164: 2159: 2155: 2151: 2147: 2140: 2137: 2132: 2128: 2123: 2118: 2113: 2108: 2104: 2100: 2096: 2089: 2086: 2081: 2077: 2072: 2067: 2063: 2059: 2055: 2051: 2047: 2040: 2037: 2032: 2028: 2024: 2020: 2013: 2010: 2005: 2001: 1996: 1991: 1987: 1983: 1979: 1972: 1969: 1964: 1960: 1956: 1952: 1947: 1942: 1938: 1934: 1930: 1923: 1920: 1915: 1911: 1906: 1901: 1896: 1891: 1887: 1883: 1879: 1872: 1869: 1864: 1860: 1855: 1850: 1846: 1842: 1838: 1834: 1830: 1823: 1820: 1815: 1811: 1806: 1801: 1796: 1791: 1787: 1783: 1779: 1775: 1771: 1764: 1761: 1756: 1752: 1748: 1744: 1740: 1733: 1730: 1725: 1721: 1717: 1713: 1709: 1705: 1698: 1691: 1688: 1683: 1679: 1674: 1669: 1665: 1661: 1657: 1653: 1649: 1642: 1639: 1634: 1630: 1625: 1620: 1616: 1612: 1608: 1604: 1600: 1593: 1590: 1585: 1581: 1576: 1571: 1567: 1563: 1559: 1555: 1551: 1544: 1541: 1536: 1532: 1527: 1522: 1517: 1512: 1508: 1504: 1500: 1493: 1491: 1487: 1482: 1478: 1474: 1470: 1466: 1462: 1454: 1451: 1446: 1442: 1438: 1434: 1429: 1424: 1420: 1416: 1412: 1405: 1402: 1397: 1393: 1388: 1383: 1379: 1375: 1371: 1367: 1363: 1356: 1354: 1350: 1345: 1341: 1336: 1331: 1327: 1323: 1319: 1315: 1311: 1304: 1301: 1296: 1292: 1288: 1284: 1280: 1276: 1269: 1266: 1261: 1255: 1253: 1249: 1244: 1240: 1234: 1231: 1226: 1222: 1216: 1213: 1209: 1205: 1200: 1198: 1196: 1192: 1188: 1184: 1179: 1177: 1175: 1171: 1165: 1163: 1161: 1157: 1153: 1149: 1145: 1141: 1137: 1133: 1129: 1125: 1121: 1117: 1112: 1110: 1106: 1102: 1098: 1094: 1089: 1087: 1082: 1078: 1074: 1070: 1069:breast cancer 1062: 1060: 1058: 1054: 1049: 1047: 1043: 1039: 1034: 1032: 1031:Golgi complex 1028: 1024: 1020: 1012: 1010: 1008: 1004: 1000: 997: 993: 989: 985: 973: 968: 964: 960: 957: 953: 946: 944: 941: 937: 933: 929: 926: 922: 918: 911: 909: 903: 899: 896: 890: 888: 884: 880: 876: 870: 866: 863: 859: 852: 850: 844: 840: 837: 831: 829: 825: 821: 817: 811: 807: 804: 802:RefSeq (mRNA) 800: 793: 792: 787: 783: 780: 774: 773: 768: 764: 761: 759: 755: 748: 747: 742: 738: 735: 729: 728: 723: 719: 716: 714: 710: 703: 702: 697: 693: 690: 684: 683: 678: 674: 671: 669: 665: 662: 659: 657: 654: 650: 647: 643: 639: 632: 628: 623: 617: 614: 612: 609: 608: 606: 603: 602: 596: 593: 591: 588: 586: 583: 581: 578: 576: 573: 571: 568: 566: 563: 562: 560: 557: 556: 550: 547: 545: 542: 541: 539: 536: 535: 532: 531:Gene ontology 528: 524: 512: 507: 503: 496: 491: 488: 486: 482: 474: 469: 458: 454: 450: 446: 442: 438: 434: 430: 426: 422: 421: 418: 414: 409: 406: 396: 392: 388: 384: 380: 376: 372: 368: 364: 360: 359: 356: 352: 347: 344: 343: 340: 338: 334: 332: 331: 327: 326: 323: 321: 317: 313: 309: 305: 297: 292: 288: 284: 279: 269: 265: 258: 251: 245: 238: 230: 226: 222: 217: 213: 208: 204: 196: 191: 187: 183: 178: 168: 164: 157: 150: 144: 137: 133: 127: 123: 119: 114: 110: 105: 101: 97: 93: 89: 85: 81: 77: 73: 69: 65: 61: 53: 48: 41: 36: 31: 27: 22: 16: 4465: 4385: 4363: 4341: 4188: 4151: 4131: 4114: 4067: 4037: 4010: 3832: 3738: 3586: 3315: 3067: 2900: 2899: 2873: 2869: 2840: 2836: 2810: 2806: 2771: 2767: 2746: 2742: 2707: 2703: 2666: 2662: 2634: 2630: 2593: 2589: 2562: 2558: 2521: 2517: 2484: 2480: 2452: 2448: 2419: 2415: 2390: 2386: 2360: 2356: 2331: 2327: 2302: 2298: 2270: 2266: 2230:(1): 19–26. 2227: 2223: 2194: 2190: 2153: 2149: 2139: 2102: 2098: 2088: 2053: 2049: 2039: 2022: 2018: 2012: 1988:(1): 29–40. 1985: 1981: 1971: 1936: 1932: 1922: 1885: 1881: 1871: 1836: 1832: 1822: 1777: 1773: 1763: 1746: 1742: 1732: 1707: 1703: 1690: 1655: 1651: 1641: 1606: 1602: 1592: 1557: 1553: 1543: 1506: 1502: 1464: 1460: 1453: 1418: 1414: 1404: 1369: 1365: 1317: 1313: 1303: 1278: 1274: 1268: 1242: 1233: 1224: 1215: 1156:angiogenesis 1113: 1090: 1066: 1050: 1038:microtubules 1035: 1016: 1002: 995: 987: 983: 982: 905: 879:NP_001136029 875:NP_001136028 872: 846: 824:NM_001142557 820:NM_001142556 813: 789: 770: 744: 725: 699: 680: 660: 655: 570:cell surface 335: 328: 193:163,491,941 180:163,460,203 55:External IDs 15: 2524:(1): 6–16. 423:Paneth cell 381:bone marrow 294:40,624,249 281:40,592,222 33:Identifiers 4954:Categories 2950:(see also 1882:BMC Cancer 1658:(1): 1–6. 1210:, May 2017 1189:, May 2017 1166:References 1152:rho kinase 1144:map kinase 1097:biomarkers 1093:hyaluronan 1086:MDA-MB-231 1084:cell line 1053:hyaluronan 1019:hyaluronan 590:centrosome 339:(ortholog) 76:HomoloGene 1652:Neoplasia 1132:integrins 908:NP_038580 887:NP_036617 883:NP_036616 849:NM_013552 828:NM_012484 816:NM_012485 646:Orthologs 565:cytoplasm 84:GeneCards 2944:Proteins 2892:19064580 2857:17922014 2827:15809329 2798:15463595 2790:15705883 2755:12939665 2734:12808028 2691:22224158 2683:12712331 2653:12225794 2618:33691799 2610:11716065 2581:11448954 2546:23843138 2538:11433424 2509:38778150 2501:11403955 2471:10882722 2436:10547355 2407:10216086 2299:Genomics 2254:17121010 2172:11448954 2131:17392272 2031:11024216 2004:25175030 1955:24053431 1914:24708576 1863:24668563 1814:24367099 1724:10029598 1682:15068665 1584:21655434 1535:20558733 1481:17922014 1445:17769149 1437:17081976 1396:12808028 1206:– 1185:– 1013:Function 956:Wikidata 625:Sources: 580:membrane 397:appendix 369:testicle 4752:301–350 4546:251–300 4498:CD240CE 4295:201–250 3979:151–200 3702:101–150 2377:9601098 2348:8890751 2319:8595891 2289:7683315 2246:7541721 2211:1602151 2122:2949353 2080:7518470 2071:2200030 1963:9302075 1905:4101830 1888:: 244. 1854:4047165 1805:3890879 1782:Bibcode 1755:9533523 1673:1635162 1633:1705559 1624:2288867 1575:3104573 1526:2924079 1344:1376732 1335:2289508 1295:6185115 1208:Ensembl 1187:Ensembl 992:protein 758:UniProt 713:Ensembl 652:Species 631:QuickGO 585:cytosol 427:condyle 314:pattern 40:Aliases 4759:CD300A 4718:CDw293 4503:CD240D 4364:CD213a 4342:CDw210 4307:CD202b 4281:CDw199 4276:CDw198 3930:CD140b 3362:51–100 2890:  2855:  2825:  2796:  2788:  2753:  2732:  2725:194876 2722:  2689:  2681:  2651:  2616:  2608:  2579:  2544:  2536:  2507:  2499:  2469:  2434:  2405:  2375:  2346:  2317:  2287:  2252:  2244:  2209:  2170:  2129:  2119:  2078:  2068:  2029:  2002:  1961:  1953:  1912:  1902:  1861:  1851:  1833:Cancer 1812:  1802:  1753:  1722:  1680:  1670:  1631:  1621:  1582:  1572:  1533:  1523:  1479:  1443:  1435:  1394:  1387:194876 1384:  1342:  1332:  1293:  1126:(FAK) 1009:168). 942:search 940:PubMed 791:Q00547 772:O75330 668:Entrez 485:BioGPS 447:atrium 389:embryo 72:104667 64:600936 4939:CD350 4934:CD349 4929:CD344 4924:CD340 4919:CD339 4914:CD338 4909:CD337 4904:CD336 4899:CD335 4894:CD334 4889:CD333 4884:CD332 4879:CD331 4874:CD329 4869:CD328 4864:CD327 4859:CD326 4854:CD325 4849:CD324 4844:CD322 4839:CD321 4834:CD320 4829:CD318 4824:CD317 4819:CD316 4814:CD315 4809:CD314 4804:CD312 4799:CD309 4794:CD307 4789:CD306 4784:CD305 4779:CD304 4774:CD303 4769:CD302 4764:CD301 4743:CD299 4738:CD298 4733:CD297 4728:CD295 4723:CD294 4713:CD292 4708:CD290 4703:CD289 4698:CD288 4693:CD286 4688:CD284 4683:CD283 4678:CD282 4673:CD281 4668:CD280 4663:CD279 4658:CD278 4653:CD276 4648:CD275 4643:CD274 4638:CD273 4633:CD272 4628:CD271 4623:CD269 4618:CD268 4613:CD267 4608:CD266 4603:CD265 4598:CD264 4593:CD263 4588:CD262 4583:CD261 4578:CD258 4573:CD257 4568:CD256 4563:CD254 4558:CD253 4553:CD252 4537:CD249 4532:CD248 4528:CD247 4523:CD246 4518:CD244 4513:CD243 4508:CD241 4493:CD239 4488:CD238 4483:CD236 4466:CD235 4461:CD234 4456:CD233 4451:CD230 4446:CD229 4441:CD228 4436:CD227 4431:CD226 4426:CD225 4421:CD224 4416:CD223 4411:CD222 4406:CD221 4401:CD220 4386:CD218 4381:CD217 4359:CD212 4337:CD209 4332:CD208 4327:CD207 4322:CD206 4317:CD205 4312:CD204 4302:CD201 4286:CD200 4271:CD197 4266:CD196 4261:CD195 4256:CD194 4251:CD193 4246:CD192 4241:CD191 4236:CD186 4231:CD185 4226:CD184 4221:CD183 4216:CD182 4211:CD181 4206:CD180 4189:CD179 4184:CD178 4179:CD177 4174:CD174 4152:CD172 4147:CD171 4142:CD170 4137:CD169 4132:CD168 4115:CD167 4110:CD166 4105:CD164 4100:CD163 4095:CD162 4090:CD161 4085:CD160 4068:CD159 4038:CD158 4033:CD157 4011:CD156 4006:CD155 4001:CD154 3996:CD153 3991:CD152 3986:CD151 3970:CD150 3965:CD148 3960:CD147 3955:CD146 3950:CD144 3945:CD143 3940:CD142 3935:CD141 3925:CD138 3920:CD137 3915:CD136 3910:CD135 3905:CD134 3900:CD133 3895:CD132 3890:CD131 3885:CD130 3880:CD129 3875:CD127 3870:CD126 3865:CD125 3860:CD124 3855:CD123 3850:CD122 3833:CD121 3816:CD120 3811:CD119 3806:CD118 3801:CD117 3796:CD116 3791:CD115 3786:CD114 3781:CD113 3776:CD112 3771:CD111 3766:CD110 3761:CD109 3756:CD108 3739:CD107 3734:CD106 3729:CD105 3724:CD104 3719:CD103 3714:CD102 3709:CD101 3693:CD100 2794:S2CID 2687:S2CID 2614:S2CID 2542:S2CID 2505:S2CID 2387:Blood 2250:S2CID 1959:S2CID 1704:Blood 1700:(PDF) 1441:S2CID 1148:c-src 1046:BARD1 1042:BRCA1 1003:CD168 990:is a 701:15366 661:Mouse 656:Human 627:Amigo 443:fossa 373:gonad 361:sperm 337:Mouse 330:Human 277:Start 212:Mouse 176:Start 109:Human 3688:CD99 3683:CD98 3678:CD97 3673:CD96 3668:CD95 3663:CD94 3658:CD93 3653:CD92 3649:CD91 3644:CD90 3639:CD89 3634:CD88 3629:CD87 3624:CD86 3587:CD85 3582:CD84 3577:CD83 3572:CD82 3567:CD81 3562:CD80 3545:CD79 3540:CD78 3535:CD74 3530:CD73 3525:CD72 3520:CD71 3515:CD70 3510:CD69 3505:CD68 3468:CD66 3446:CD64 3441:CD63 3419:CD62 3414:CD61 3409:CD59 3404:CD58 3399:CD57 3394:CD56 3389:CD55 3384:CD54 3379:CD53 3374:CD52 3369:CD51 3353:CD50 3316:CD49 3311:CD48 3306:CD47 3301:CD46 3296:CD45 3291:CD44 3286:CD43 3259:CD42 3254:CD41 3249:CD40 3244:CD39 3239:CD38 3234:CD37 3229:CD36 3224:CD35 3219:CD34 3214:CD33 3197:CD32 3192:CD31 3187:CD30 3182:CD29 3177:CD28 3172:CD27 3167:CD26 3162:CD25 3157:CD24 3152:CD23 3147:CD22 3142:CD21 3137:CD20 3132:CD19 3127:CD18 3110:CD16 3105:CD15 3100:CD14 3095:CD13 3068:CD11 3063:CD10 2960:1–50 2888:PMID 2853:PMID 2823:PMID 2786:PMID 2751:PMID 2730:PMID 2679:PMID 2649:PMID 2606:PMID 2577:PMID 2534:PMID 2497:PMID 2467:PMID 2432:PMID 2403:PMID 2373:PMID 2344:PMID 2328:Gene 2315:PMID 2285:PMID 2242:PMID 2224:Cell 2207:PMID 2168:PMID 2127:PMID 2076:PMID 2027:PMID 2000:PMID 1951:PMID 1910:PMID 1859:PMID 1810:PMID 1751:PMID 1720:PMID 1678:PMID 1629:PMID 1580:PMID 1531:PMID 1477:PMID 1433:PMID 1415:Cell 1392:PMID 1340:PMID 1291:PMID 1140:ERK2 1136:ERK1 1103:and 1077:HER2 1075:and 1044:and 1023:CD44 999:gene 996:HMMR 682:3161 320:Bgee 268:Band 229:Chr. 172:5q34 167:Band 126:Chr. 88:HMMR 80:8271 60:OMIM 47:HMMR 24:HMMR 3058:CD9 3046:CD8 3041:CD7 3036:CD6 3031:CD5 3026:CD4 3004:CD3 2999:CD2 2972:a-c 2967:CD1 2878:doi 2845:doi 2815:doi 2811:137 2776:doi 2720:PMC 2712:doi 2671:doi 2667:129 2639:doi 2598:doi 2567:doi 2563:276 2526:doi 2489:doi 2485:306 2457:doi 2453:275 2424:doi 2420:112 2395:doi 2365:doi 2361:111 2336:doi 2332:174 2307:doi 2275:doi 2271:150 2232:doi 2199:doi 2158:doi 2154:276 2117:PMC 2107:doi 2103:282 2066:PMC 2058:doi 2054:126 1990:doi 1986:234 1941:doi 1937:113 1900:PMC 1890:doi 1849:PMC 1841:doi 1837:120 1800:PMC 1790:doi 1778:111 1712:doi 1668:PMC 1660:doi 1619:PMC 1611:doi 1607:112 1570:PMC 1562:doi 1521:PMC 1511:doi 1507:285 1469:doi 1423:doi 1419:127 1382:PMC 1374:doi 1330:PMC 1322:doi 1318:117 1283:doi 1279:108 290:End 189:End 92:OMA 68:MGI 4956:: 4530:- 3651:- 2992:1E 2987:1D 2982:1B 2977:1A 2946:: 2886:. 2874:17 2872:. 2868:. 2851:. 2841:39 2839:. 2821:. 2809:. 2792:. 2784:. 2772:65 2770:. 2766:. 2747:24 2745:. 2728:. 2718:. 2708:14 2706:. 2702:. 2685:. 2677:. 2665:. 2647:. 2635:30 2633:. 2629:. 2612:. 2604:. 2594:53 2592:. 2575:. 2561:. 2557:. 2540:. 2532:. 2522:65 2520:. 2503:. 2495:. 2483:. 2465:. 2451:. 2447:. 2430:. 2418:. 2401:. 2391:93 2389:. 2371:. 2359:. 2342:. 2330:. 2313:. 2303:30 2301:. 2283:. 2269:. 2265:. 2248:. 2240:. 2228:82 2226:. 2222:. 2205:. 2195:24 2193:. 2166:. 2152:. 2148:. 2125:. 2115:. 2101:. 2097:. 2074:. 2064:. 2052:. 2048:. 2023:17 1998:. 1984:. 1980:. 1957:. 1949:. 1935:. 1931:. 1908:. 1898:. 1886:14 1884:. 1880:. 1857:. 1847:. 1835:. 1831:. 1808:. 1798:. 1788:. 1776:. 1772:. 1745:. 1741:. 1718:. 1708:93 1706:. 1702:. 1676:. 1666:. 1654:. 1650:. 1627:. 1617:. 1605:. 1601:. 1578:. 1568:. 1556:. 1552:. 1529:. 1519:. 1505:. 1501:. 1489:^ 1475:. 1465:39 1463:. 1439:. 1431:. 1417:. 1413:. 1390:. 1380:. 1370:14 1368:. 1364:. 1352:^ 1338:. 1328:. 1316:. 1312:. 1289:. 1277:. 1251:^ 1241:. 1223:. 1194:^ 1173:^ 1138:/ 1111:. 1088:. 1029:/ 629:/ 296:bp 283:bp 195:bp 182:bp 90:; 86:: 82:; 78:: 74:; 70:: 66:; 62:: 4476:b 4471:a 4397:) 4395:b 4390:a 4388:( 4374:2 4369:1 4352:b 4347:a 4199:b 4194:a 4167:g 4162:b 4157:a 4125:b 4120:a 4078:c 4073:a 4064:) 4062:k 4057:i 4052:e 4047:d 4042:a 4040:( 4026:c 4021:b 4016:a 3843:b 3838:a 3826:b 3821:a 3749:b 3744:a 3617:k 3612:j 3607:h 3602:e 3597:d 3592:a 3555:b 3550:a 3498:f 3493:e 3488:d 3483:c 3478:b 3473:a 3461:C 3456:B 3451:A 3434:P 3429:L 3424:E 3346:f 3341:e 3336:d 3331:c 3326:b 3321:a 3279:d 3274:c 3269:b 3264:a 3207:B 3202:A 3120:B 3115:A 3088:d 3083:c 3078:b 3073:a 3051:a 3019:ε 3014:δ 3009:γ 2954:) 2936:e 2929:t 2922:v 2909:. 2894:. 2880:: 2859:. 2847:: 2829:. 2817:: 2800:. 2778:: 2757:. 2736:. 2714:: 2693:. 2673:: 2655:. 2641:: 2620:. 2600:: 2583:. 2569:: 2548:. 2528:: 2511:. 2491:: 2473:. 2459:: 2438:. 2426:: 2409:. 2397:: 2379:. 2367:: 2350:. 2338:: 2321:. 2309:: 2291:. 2277:: 2256:. 2234:: 2213:. 2201:: 2174:. 2160:: 2133:. 2109:: 2082:. 2060:: 2033:. 2006:. 1992:: 1965:. 1943:: 1916:. 1892:: 1865:. 1843:: 1816:. 1792:: 1784:: 1757:. 1747:4 1726:. 1714:: 1684:. 1662:: 1656:6 1635:. 1613:: 1586:. 1564:: 1558:4 1537:. 1513:: 1483:. 1471:: 1447:. 1425:: 1398:. 1376:: 1346:. 1324:: 1297:. 1285:: 1262:. 1245:. 1227:. 1005:( 214:) 111:) 94::

Index

Aliases
HMMR
OMIM
600936
MGI
104667
HomoloGene
8271
GeneCards
HMMR
OMA
HMMR - orthologs
Human
Chromosome 5 (human)
Chr.
Chromosome 5 (human)
Chromosome 5 (human)
Genomic location for HMMR
Genomic location for HMMR
Band
bp
bp
Mouse
Chromosome 11 (mouse)
Chr.
Chromosome 11 (mouse)
Genomic location for HMMR
Genomic location for HMMR
Band
bp

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