Knowledge (XXG)

Androgen deficiency

Source πŸ“

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Diagnosis of androgenic deficiency in males is based on symptoms together with at least two measurements of testosterone done first thing in the morning after a period of not eating. In those without symptoms, testing is not generally recommended. Androgen deficiency is not usually checked for
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Guay, A.; Munarriz, R.; Jacobson, J.; Talakoub, L.; Traish, A.; Quirk, F.; Goldstein, I.; Spark, R. (April 24, 2004). "Serum androgen levels in healthy premenopausal women with and without sexual dysfunction: Part A. Serum androgen levels in women aged 20–49 years with no complaints of sexual
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Barratt, Christopher L R; BjΓΆrndahl, Lars; De Jonge, Christopher J; Lamb, Dolores J; Osorio Martini, Francisco; McLachlan, Robert; Oates, Robert D; van der Poel, Sheryl; St John, Bianca; Sigman, Mark; Sokol, Rebecca; Tournaye, Herman (2017-11-01).
450: 1756:"Testosterone Products: Drug Safety Communication β€” FDA Cautions About Using Testosterone Products for Low Testosterone Due to Aging; Requires Labeling Change to Inform of Possible Increased Risk of Heart Attack And Stroke" 443: 1396:"Re: Christina Wang, Eberhard Nieschlag, Ronald Swerdloff, et al. Investigation, Treatment, and Monitoring of Late-Onset Hypogonadism in Males: ISA, ISSAM, EAU, EAA, and ASA Recommendations. Eur Urol 2009;55:121–30" 73:), and is dependent on various factors including androgen receptor abundance, sensitivity and function. Androgen deficiency is associated with lack of energy and motivation, depression, lack of desire ( 436:. The FDA has required that testosterone pharmaceutical labels include warning information about the possibility of an increased risk of heart attacks and stroke. 1865: 1655:"The diagnosis of male infertility: an analysis of the evidence to support the development of global WHO guidanceβ€”challenges and future research opportunities" 1800: 1993: 1908: 1903: 1898: 413: 1629: 1893: 1755: 1354:"Corrigendum to: "Testosterone Therapy in Adult Men with Androgen Deficiency Syndromes: An Endocrine Society Clinical Practice Guideline"" 1039:
Bhasin, S; Brito, JP; Cunningham, GR; Hayes, FJ; Hodis, HN; Matsumoto, AM; Snyder, PJ; Swerdloff, RS; Wu, FC; Yialamas, MA (1 May 2018).
2079: 232:, with some mixed atrophy of type II (fast-twitch/glycolytic) muscle fibres. Treatment is hormone replacement therapy of testosterone. 2069: 2074: 2048: 2013: 1888: 1444:, Ch. 38 Endocrine myopathies. Oxford Textbooks in Clinical Neurology (Oxford, 2014; online edn, Oxford Academic, 1 May 2014), 360: 2018: 1793: 409: 316: 293: 2023: 1988: 307: 2084: 2033: 2003: 1860: 425: 324: 78: 395: 2043: 1924: 1440:
Needham, Merrilee, and Frank Mastaglia, 'Endocrine myopathies', in David Hilton-Jones, and Martin R. Turner (eds),
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Guay, A; Traish, A (October 2010). "Testosterone therapy in women with androgen deficiency: Its time has come".
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showed low volitional contraction of short duration polyphasic units. Muscle biopsy showed evidence of
65:(FAIS), although it can happen in both sexes. Androgenic activity is mediated by androgens (a class of 2008: 936: 757: 2038: 487: 1462:
Orrell, R W; Woodrow, D F; Barrett, M C; Press, M; Dick, D J; Rowe, R C; Lane, R J (August 1995).
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Wierman ME, Arlt W, Basson R, Davis SR, Miller KK, Murad MH, Rosner W, Santoro N (October 2014).
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may also be a factor in the development of hypoandrogenism, as androgen levels decline with age.
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Men produce about 3 to 11 mg of testosterone per day (mean 7 mg/day in young men).
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Hypoandrogenism, androgen deficiency syndrome, men with hypogonadism, testosterone deficiency
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or (hypogonadotropic) hypogonadism with myopathy. Signs and symptoms include elevated serum
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activity in the body. Androgen deficiency most commonly affects women, and is also called
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Hypoandrogenism is primarily caused by either dysfunction, failure, or absence of the
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Rivera-Woll, L. M.; Papalia, M.; Davis, S. R.; Burger, H. G. (October 1, 2004).
572: 264: 118: 98: 1178: 17: 221: 1678: 1528: 1479: 1419: 1377: 1369: 1202:"Testosterone replacement therapy for female androgen insufficiency syndrome" 311:). This in turn can be caused by a multitude of different stimuli, including 1670: 1512: 1353: 1323: 1098: 1081: 348: 240: 146: 122: 94: 1737: 1696: 1604: 1563: 1536: 1427: 1331: 1287: 1252: 1217: 1186: 1151: 1107: 1066: 1497: 1082:"Androgen insufficiency in women: diagnostic and therapeutic implications" 1057: 1040: 1845: 1728: 1711: 980: 399: 225: 213: 201: 181: 154: 150: 110: 102: 58: 1165:
Braunstein, Glenn D. (July 1, 2006). "Androgen insufficiency in women".
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Davison, Sonia L; Davis, Susan R (June 1, 2003). "Androgens in women".
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may be present in both sexes in cases of severe androgen deficiency.
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Androgen replacement therapy formulations and dosages used in men
352: 328: 288: 256: 106: 428:(FDA) stated in 2015 that neither the benefits nor the safety of 356: 1782: 964:= Never marketed. = No longer used and/or no longer marketed. 275:
mass. As estrogens are synthesized from androgens, symptoms of
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The Journal of Steroid Biochemistry and Molecular Biology
1513:"Hypogonadotropic Hypogonadism in a Boy with Myopathy" 1358:
The Journal of Clinical Endocrinology & Metabolism
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Symptoms of the condition in males consist of loss of
1579:"The hypoandrogenic woman: pathophysiologic overview" 1511:
Haq, T.; Pathan, M. F.; Ikhtaire, S. (January 2016).
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The Journal of Clinical Endocrinology and Metabolism
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Ponholzer, Anton; Madersbacher, Stephan (May 2009).
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The Journal of Clinical Endocrinology and Metabolism
228:). A predominance of type I (slow-twitch/oxidative) 220:, some fibre splitting, chronic inflammatory cells ( 1937: 1917: 1879: 1853: 1844: 1816: 1206:
International Journal of Pharmaceutical Compounding
40: 35: 402:in those with symptoms. Treatment mostly improves 762: 235:In females, hypoandrogenism consist of loss of 771: 1794: 451: 204:), a burning sensation in the feet at night, 184:can result from androgen deficiency known as 8: 1866:17Ξ²-Hydroxysteroid dehydrogenase deficiency 1312:International Journal of Impotence Research 931:600–1,000 mg 1×/12–20 weeks 915:750–1,000 mg 1×/10–14 weeks 718: 1850: 1801: 1787: 1779: 1749: 1747: 1442:Oxford Textbook of Neuromuscular Disorders 458: 444: 438: 32: 1994:Cytochrome P450 oxidoreductase deficiency 1727: 1686: 1594: 1487: 1141: 1097: 1056: 1034: 1032: 1030: 1028: 1026: 519:40–80 mg/2–4× day (with meals) 1909:Familial male-limited precocious puberty 1904:Complete androgen insensitivity syndrome 1468:Journal of the Royal Society of Medicine 1276:Current Opinion in Investigational Drugs 177:, may be concurrently present in males. 1899:Partial androgen insensitivity syndrome 1022: 955: 503:400–800 mg/day (in divided doses) 77:), and in more severe cases changes in 1119: 1117: 899:50–250 mg 1×/2–4 weeks 883:50–200 mg 1×/3–5 weeks 439: 63:Female androgen insufficiency syndrome 1894:Mild androgen insensitivity syndrome 1389: 1387: 1124:Braunstein, Glenn D (April 1, 2002). 27:Lack of androgen hormones in the body 7: 434:low testosterone levels due to aging 325:enzymatic defects of steroidogenesis 1624:. Humana Press. pp. 365–379. 1464:"Testosterone deficiency myopathy" 1450:10.1093/med/9780199698073.003.0034 952:150–1,200 mg/3–6 months 545:Halotestin, Ora-Testryl, Ultandren 25: 1167:Growth Hormone & IGF Research 867:50–100 mg 1x/1–2 weeks 851:50–250 mg 1x/1–4 weeks 824:50–250 mg 1x/1–4 weeks 683:Androderm, AndroPatch, TestoPatch 786:Andronaq, Sterotate, Virosterone 208:, and impaired fasting glucose. 186:testosterone deficiency myopathy 69:with varying affinities for the 2049:Hypergonadotropic hypergonadism 2014:Estrogen insensitivity syndrome 1889:Androgen insensitivity syndrome 1621:Androgens in Health and Disease 1517:Mymensingh Medical Journal: MMJ 767:Tooltip intramuscular injection 361:androgen insensitivity syndrome 2019:Hypergonadotropic hypogonadism 1550:Jakiel G, Baran A (2005). "". 1406:(5): e92, author reply e93-4. 776:Tooltip subcutaneous injection 410:Gonadotropin-releasing hormone 57:characterized by insufficient 1: 2024:Hypogonadotropic hypogonadism 1989:Postorgasmic illness syndrome 1596:10.1016/S0015-0282(02)03003-0 1245:10.1016/S0960-0760(03)00204-8 1143:10.1016/S0015-0282(02)02962-X 808:10–50 mg 2–3×/week 792:10–50 mg 2–3×/week 420:may be given (in the case of 79:secondary sex characteristics 2034:Estrogen-dependent condition 2004:Androgen-dependent condition 1412:10.1016/j.eururo.2008.11.053 835:50–100 mg 1×/week 426:Food and Drug Administration 380:diagnosis in healthy women. 604:5–10 mg 1–4×/day 529:Android, Metandren, Testred 396:hormone replacement therapy 165:. In addition, symptoms of 2101: 2080:Animal reproductive system 2044:Gonadotropin insensitivity 1925:Sertoli cell-only syndrome 1618:Bremner WJ (27 May 2003). 1577:Bachmann GA (April 2002). 1179:10.1016/j.ghir.2006.03.009 893:Sustanon 100, Sustanon 250 873:Testosterone phenylacetate 756: 672:AndroGel, Testim, TestoGel 432:have been established for 387: 2070:Endocrine gonad disorders 1871:Aromatase excess syndrome 1861:5Ξ±-reductase 2 deficiency 1831:Premature ovarian failure 1826:Polycystic ovary syndrome 1659:Human Reproduction Update 1086:Human Reproduction Update 956: 889:Mixed testosterone esters 812: 752:40 mg 2–3×/day 666: 661: 624: 587: 486: 394:Treatment may consist of 390:Testosterone (medication) 1999:Cytochrome b5 deficiency 1452:. Retrieved 29 May 2023. 1364:(7): e2843. 2021-05-17. 905:Testosterone undecanoate 857:Testosterone isobutyrate 651:Metandren, Oreton Methyl 614:Metandren, Oreton Methyl 509:Testosterone undecanoate 267:), insomnia, headaches, 2029:Fertile eunuch syndrome 1583:Fertility and Sterility 1324:10.1038/sj.ijir.3901178 1130:Fertility and Sterility 1011:Late-onset hypogonadism 798:Testosterone propionate 746:Rektandron, Testosteron 641:30 mg 2×/day 297:) or impairment of the 263:(e.g., hot flashes and 2075:Male genital disorders 1754:Staff (3 March 2015). 1370:10.1210/clinem/dgab306 921:Testosterone buciclate 841:Testosterone cypionate 814:Testosterone enanthate 424:hypoandrogenism). The 253:vaginal vasocongestion 1671:10.1093/humupd/dmx021 1552:Endokrynologia Polska 1200:Tan, RS (July 2005). 1099:10.1093/humupd/dmh037 1058:10.1210/jc.2018-00229 255:(which can result in 2009:Aromatase deficiency 1729:10.1210/jc.2014-2260 877:Perandren, Androject 731:100–250 mg/day 180:In males, a type of 2085:Intersex variations 2039:Premature thelarche 711:30–120 mg/day 689:2.5–15 mg/day 678:25–125 mg/day 583:25–150 mg/day 466: 101:, shrinkage of the 51:Androgen deficiency 36:Androgen deficiency 1962:Precocious puberty 1589:(Suppl 4): S72–6. 928:Aqueous suspension 864:Aqueous suspension 789:Aqueous suspension 647:Methyltestosterone 620:10–30 mg/day 610:Methyltestosterone 535:10–50 mg/day 525:Methyltestosterone 323:insensitivity and 313:genetic conditions 261:vasomotor symptoms 143:vasomotor symptoms 85:Signs and symptoms 2057: 2056: 1933: 1932: 1881:Androgen receptor 1631:978-1-58829-029-8 972: 971: 845:Depo-Testosterone 708:Axillary solution 686:Non-scrotal patch 657:5–25 mg/day 567:5–15 mg/day 551:5–20 mg/day 476:Major brand names 294:hypergonadotropic 117:(e.g., decreased 71:androgen receptor 55:medical condition 48: 47: 30:Medical condition 16:(Redirected from 2092: 1984:Hyperestrogenism 1979:Hyperandrogenism 1851: 1810:Gonadal disorder 1803: 1796: 1789: 1780: 1773: 1772: 1770: 1768: 1751: 1742: 1741: 1731: 1722:(10): 3489–510. 1707: 1701: 1700: 1690: 1649: 1643: 1642: 1640: 1638: 1615: 1609: 1608: 1598: 1574: 1568: 1567: 1547: 1541: 1540: 1508: 1502: 1501: 1491: 1459: 1453: 1438: 1432: 1431: 1400:European Urology 1391: 1382: 1381: 1350: 1344: 1343: 1306: 1300: 1299: 1271: 1265: 1264: 1228: 1222: 1221: 1197: 1191: 1190: 1162: 1156: 1155: 1145: 1121: 1112: 1111: 1101: 1077: 1071: 1070: 1060: 1051:(5): 1715–1744. 1036: 991:Hyperestrogenism 986:Hyperandrogenism 777: 773: 768: 764: 720: 717:Androstanolone ( 700:4–6 mg/day 513:Andriol, Jatenzo 467: 460: 453: 446: 422:hypogonadotropic 365:hyperestrogenism 308:hypogonadotropic 167:hyperestrogenism 67:steroid hormones 33: 21: 2100: 2099: 2095: 2094: 2093: 2091: 2090: 2089: 2060: 2059: 2058: 2053: 1974:Hypoestrogenism 1969:Hypoandrogenism 1950:Delayed puberty 1929: 1913: 1875: 1840: 1812: 1807: 1777: 1776: 1766: 1764: 1753: 1752: 1745: 1709: 1708: 1704: 1651: 1650: 1646: 1636: 1634: 1632: 1617: 1616: 1612: 1576: 1575: 1571: 1549: 1548: 1544: 1510: 1509: 1505: 1461: 1460: 1456: 1439: 1435: 1393: 1392: 1385: 1352: 1351: 1347: 1308: 1307: 1303: 1282:(10): 1116–26. 1273: 1272: 1268: 1230: 1229: 1225: 1199: 1198: 1194: 1164: 1163: 1159: 1123: 1122: 1115: 1079: 1078: 1074: 1038: 1037: 1024: 1019: 1001:Hypoestrogenism 977: 775: 766: 541:Fluoxymesterone 464: 404:sexual function 392: 386: 377: 303:pituitary gland 285: 277:hypoestrogenism 200:(predominantly 198:muscle weakness 115:masculinization 87: 31: 28: 23: 22: 18:Hypoandrogenism 15: 12: 11: 5: 2098: 2096: 2088: 2087: 2082: 2077: 2072: 2062: 2061: 2055: 2054: 2052: 2051: 2046: 2041: 2036: 2031: 2026: 2021: 2016: 2011: 2006: 2001: 1996: 1991: 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Index

Hypoandrogenism
medical condition
androgenic
steroid hormones
androgen receptor
libido
secondary sex characteristics
libido
impotence
infertility
testicles
penis
prostate
masculinization
facial
body hair
muscle
anxiety
depression
fatigue
vasomotor symptoms
hot flashes
insomnia
headaches
cardiomyopathy
osteoporosis
hyperestrogenism
gynecomastia
feminization
myopathy

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