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decided because of the complex genetic characteristics of DPB1 alleles compared to alleles of other HLA loci. The majority of the HLA-DPB1 alleles cannot be simply grouped together by their nucleotide sequences. This name assignment has been the most confusing system within the HLA nomenclature. In the 2010 HLA nomenclature update, all DPB1 alleles, except DPB1*0202 and *0402, discovered after DPB1*9901 were reassigned with new numbers. For example, DPB1*0102 becomes DPB1*100:01 and DPB1*0203 becomes DPB1*101:01.
171:. Each DP subunit (α-subunit, β-subunit) is composed of a α-helical N-terminal domain, an IgG-like β-sheet, a membrane spanning domain, and a cytoplasmic domain. The α-helical domain forms the sides of the peptide binding groove. The β-sheet regions form the base of the binding groove and the bulk of the molecule as well as the inter-subunit (non-covalent) binding region.
192:(APC)(macrophages, dendritic cells, and B-lymphocytes). Normally, these APC 'present' class II receptor/antigens to a great many T-cells, each with unique T-cell receptor (TCR) variants. A few TCR variants that recognize these DQ/antigen complexes are on CD4 positive T-cells. These T-cells, called T-helper (T
187:
of humans, however this antigen is an artifact of the era of organ transplantation. HLA DP functions as a cell surface receptor for foreign or self antigens. The immune system surveys antigens for foreign pathogens when presented by MHC receptors (like HLA-DP). The MHC Class II antigens are found on
564:
Before the April 2010 HLA nomenclature update, new HLA-DPB1 allele names were assigned within the existing nomenclature system. For example, the allele discovered after HLA-DPB1*9901 was assigned as DPB1*0102, the subsequent allele was named DPB1*0202, then *0302 and so on. This name assignment was
882:
Marsh, S. G. E., Albert, E. D., Bodmer, W. F., Bontrop, R. E., Dupont, B., Erlich, H. A., Fernández-Viña, M., Geraghty, D. E., Holdsworth, R., Hurley, C. K., Lau, M., Lee, K. W., Mach, B., Maiers, M., Mayr, W. R., Müller, C. R., Parham, P., Petersdorf, E. W., Sasazuki, T., Strominger, J. L.,
370:
These 'cis'-isoforms will account for at least 50% of the DP isoforms. The other, trans isoforms are typically more rare, isoforms result from random 'trans' combinations of haplotypes in individuals as a result of 'trans' paternal/maternal gene product isoforms.
802:. This tool allows you to enter an HLA allele name and will provide you with both the current and new versions of the allele name. New alleles that have never been assigned with a name prior to the April 2010 update are:
200:
consume or destroy cells by apoptotic signaling and present self-antigens. Self antigens, in the right context, form a regulatory T-cell population that protects self tissues from immune attack or autoimmunity.
932:
227:
complex DP locus is more frequently substituted, either as a result of its distance from other loci, or because it was not as actively selected in the evolution of
209:
The α-chain and β- of DP is encoded by the HLA-DPA1 locus and HLA-DPB1 loci, respectively. This cluster is located at the proximal (centromeric) end of the
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196:) cells, can promote the amplification of B-cells that recognize a different portion of the same antigen. Alternatively, macrophages and other
363:
Each combination of DPA1 allele gene product with each combination of DPB1 'gene' product can potentially recombine to produce one isoform.
1236:
791:
To aid in migration of data to the new nomenclature the WHO Nomenclature
Committee for Factors of the HLA System has provided the
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in the human population. In a typical population there are many DP alpha and beta. Most isoforms are not common.
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complex on human chromosome 6 (see protein boxes on right for links). Less is known about HLA-DP relative to
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128:
108:
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35:
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961:
926:
168:
1180:
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encoding loci and therefore is much more equilibrated with respect to other HLA loci. In the
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antigen that is composed of 2 subunits, DPα and DPβ. DPα and DPβ are encoded by two loci,
909:
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900:
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All renamed alleles are listed in the HLA-DPB1 Nomenclature
Conversion Chart below.
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180:
91:
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19:
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DP(αβ) Isoforms given one maternal (m) and one paternal (p) chromosome 6
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Svejgaard, A., Terasaki, P. I., Tiercy, J. M., Trowsdale, J. (2010).
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ftp://ftp.ebi.ac.uk/pub/databases/imgt/mhc/hla/Nomenclature_2009.txt
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The name 'HLA-DP' originally describes a transplantation antigen of
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but the sequencing of DP types and determination of more frequent
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18:
885:"Nomenclature for factors of the HLA system, 2010"
143:has progressed greatly within the last few years.
213:in human chromosome 6p21.31. It is distal from
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8:
931:: CS1 maint: multiple names: authors list (
863:HLA Allele and Haplotype Frequency Database
235:Understanding the Heterodimeric DP Isoforms
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155:HLA DP Receptor with bound peptide and TCR
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851:The IMGT/HLA Database - HLA Dictionary.
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793:IMGT/HLA Nomenclature Conversion Tool
7:
560:HLA-DPB1 Allele Nomenclature Change
833:HLA-DPA1*01:03/DPB1*04:02 (DP402)
828:HLA-DPA1*01:03/DPB1*04:01 (DP401)
127:Class II (or HLA-D) region in the
14:
1176:Minor histocompatibility antigen
985:Major histocompatibility complex
901:10.1111/j.1399-0039.2010.01466.x
185:major histocompatibility complex
147:Structure, Functions, Genetics
1:
107:is a protein/peptide-antigen
52:
365:DP genes are highly variable
1237:Genes on human chromosome 6
846:Nomenclature of HLA Alleles
1258:
1206:Cluster of differentiation
404:
1196:Human blood group systems
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552:DPB1*11:01 - DPB1*129:01
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343:, isoforms and 2 trans,
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273:
266:
261:
113:graft-versus-host disease
51:
26:
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190:antigen presenting cells
123:, that are found in the
1201:Cell adhesion molecules
1171:Human leukocyte antigen
129:Human Leukocyte Antigen
1227:Protein heteropolymers
156:
45:Immune recognition and
1232:Human MHC haplogroups
198:cytotoxic lymphocytes
169:cell-surface receptor
154:
36:cell surface receptor
821:Common DP Haplotypes
47:antigen presentation
241:
856:2012-09-25 at the
798:2012-08-04 at the
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62:Chromosomal locus
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1181:Blood transfusion
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446:HLA-DPB1 Alleles
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380:HLA-DPA1 Alleles
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183:category of the
164:HLA-DP is an αβ-
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889:Tissue Antigens
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574:Previous Names
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329:Result: 2 Cis,
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895:(4): 291–455.
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840:External links
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745:DPB1*120:01N
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92:Chromosome 6p
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76:Chromosome 6p
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27:(heterodimer)
25:
21:
17:
1242:MHC class II
1078:
1037:MHC class II
941:
927:cite journal
892:
888:
877:
814:DPB1*129:01
808:DPB1*126:01
790:
785:DPB1*125:01
777:DPB1*124:01
769:DPB1*123:01
761:DPB1*122:01
753:DPB1*121:01
737:DPB1*119:01
729:DPB1*118:01
721:DPB1*117:01
713:DPB1*116:01
705:DPB1*115:01
697:DPB1*114:01
689:DPB1*113:01
681:DPB1*112:01
673:DPB1*111:01
665:DPB1*110:01
657:DPB1*109:01
649:DPB1*108:01
641:DPB1*107:01
633:DPB1*106:01
625:DPB1*105:01
617:DPB1*104:01
609:DPB1*103:01
601:DPB1*102:01
593:DPB1*101:01
585:DPB1*100:01
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228:
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181:MHC class II
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163:
104:
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56:Subunit name
32:Protein type
20:MHC class II
1191:Calgranulin
994:MHC class I
812:DPB1*128:01
810:DPB1*127:01
166:heterodimer
1221:Categories
869:References
742:DPB1*2302N
141:haplotypes
782:DPB1*2802
774:DPB1*2702
766:DPB1*2602
758:DPB1*2502
750:DPB1*2402
734:DPB1*2202
726:DPB1*2102
718:DPB1*2002
710:DPB1*1902
702:DPB1*1802
694:DPB1*1702
686:DPB1*1602
678:DPB1*1502
670:DPB1*1402
662:DPB1*1302
654:DPB1*1102
646:DPB1*1002
638:DPB1*0902
630:DPB1*0802
622:DPB1*0602
614:DPB1*0502
606:DPB1*0403
598:DPB1*0302
590:DPB1*0203
582:DPB1*0102
453:HLA-DPB1
387:HLA-DPA1
160:Structure
1186:Arrestin
919:20356336
854:Archived
796:Archived
315:(Trans)
299:(Trans)
229:Super B8
224:Super B8
205:Genetics
175:Function
121:HLA-DPB1
117:HLA-DPA1
109:receptor
87:HLA-DPB1
71:HLA-DPA1
42:Function
987:classes
910:2848993
547:*10:01
539:*09:01
531:*08:01
523:*07:01
515:*06:01
507:*05:01
499:*04:02
492:*04:01
484:*03:01
476:*02:02
469:*02:01
461:*01:01
439:*04:01
436:*03:03
429:*02:04
420:*01:10
375:Alleles
324:(Cis )
290:(Cis )
259:allele
1128:HLA-DR
1096:HLA-DQ
1079:HLA-DP
1062:HLA-DO
1045:HLA-DM
917:
907:
434:*03:02
432:*03:01
427:*02:03
425:*02:02
423:*02:01
418:*01:09
416:*01:08
414:*01:07
412:*01:06
410:*01:05
408:*01:04
406:*01:03
350:&
336:&
219:HLA-DQ
215:HLA-DR
137:HLA-DR
133:HLA-DQ
105:HLA-DP
94:21.31
78:21.31
1164:Other
1027:HLA-G
1022:HLA-F
1017:HLA-E
1012:HLA-C
1007:HLA-B
1002:HLA-A
933:link
915:PMID
544:*10
536:*09
528:*08
520:*07
512:*06
504:*05
489:*04
481:*03
466:*02
458:*01
401:*04
275:DPA1
251:DPB1
217:and
135:and
119:and
111:and
59:Gene
22:, DP
905:PMC
897:doi
398:*03
395:*02
392:*01
305:(p)
280:(m)
268:(p)
263:(m)
245:HLA
125:MHC
1223::
1153:β5
1148:β4
1143:β3
1138:β1
1121:β3
1116:β2
1111:β1
1106:α2
1101:α1
1089:β1
1084:α1
929:}}
925:{{
913:.
903:.
893:75
891:.
887:.
357:.
231:.
1133:α
1072:β
1067:α
1055:β
1050:α
977:e
970:t
963:v
935:)
921:.
899::
355:β
352:α
348:β
345:α
341:β
338:α
334:β
331:α
322:β
319:α
313:β
310:α
297:β
294:α
288:β
285:α
194:h
83:β
67:α
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