Knowledge (XXG)

HLA-DR12

Source πŸ“

800:"The association between HLA DR, DQ antigens, and vulval lichen sclerosus in the UK: HLA DRB112 and its associated DRB112/DQB10301/04/09/010 haplotype confers susceptibility to vulval lichen sclerosus, and HLA DRB10301/04 and its associated DRB10301/04/DQB10201/02/03 haplotype protects from vulval lichen sclerosus" 21: 1004:
Himmunngan P, Sangwatanaroj S, Petmitr S, Viroonudomphol D, Siriyong P, Patmasiriwat P (2006). "HLa-class II (DRB & DQB1) in Thai sudden unexplained death syndrome (Thai SUDS) families (Lai-Tai families)".
901:
Vargas-Alarcon G, Granados J, Bekker C, Alcocer-Varela J, AlarcΓ³n-Segovia D (1995). "Association of HLA-DR5 (possibly DRB1*1201) with the primary antiphospholipid syndrome in Mexican patients".
1032:
Tighe M, Hall M, Barbado M, Cardi E, Welsh K, Ciclitira P (1992). "HLA class II alleles associated with celiac disease susceptibility in a southern European population".
20: 350:
The table above describes the efficiency of serological typing of DR12 and DR5. Serotypes are unknown the following alleles: DRB1*1204,*1205 to *1207 to *1215
358:
There are only 2 common allels for DRB1*12, *1201 and *1202. *1202 is more common on the West Pacific Rim and particularly Indochina and the South Pacific.
936:
Ju LY, Paolozzi L, Delecoeuillerie G, et al. (1994). "A possible linkage of HLA-DRB haplotypes with Tiopronin intolerance in rheumatoid arthritis".
1155: 167: 148: 409:
is found to be increased in narcolepsy associated sudden death syndrome in the Thai population, and narcolepsy in the Japanese population.
178: 159: 140: 128: 82: 965:"Cytokine and immunogenetic profiles in Japanese patients with adult Still's disease. Association with chronic articular disease" 1067:
Bidwell J, Soong T, Raymond P, Doherty D, Hui K (1992). "HLA genotyping of colorectal carcinoma in the Chinese population".
874:
Cerna M, Vavrincova P, Havelka S, Ivaskova E, Stastny P (1994). "Class II alleles in juvenile arthritis in Czech children".
401: 1102:
Song EY, Park H, Roh EY, Park MH (2004). "HLA-DRB1 and -DRB3 allele frequencies and haplotypic associations in Koreans".
1376: 1148: 389: 116: 70: 839:
Liao HT, Lin KC, Chen CH, et al. (2007). "Human Leukocyte Antigens in Undifferentiated Spondyloarthritis".
219: 75: 798:
Gao X, Barnardo M, Winsey S, Ahmad T, Cook J, Agudelo J, Zhai N, Powell J, Fuggle S, Wojnarowska F (2005).
1141: 121: 397: 202: 963:
Fujii T, Nojima T, Yasuoka H, Satoh S, Nakamura K, Kuwana M, Suwa A, Hirakata M, Mimori T (2001).
206: 385: 183: 164: 145: 133: 15: 436: 87: 1119: 1084: 1049: 1014: 986: 945: 918: 883: 856: 821: 427: 371: 229:
that recognizes the DRB1*1201 to *1203, *1206. DR12 serotype is a split antigen of the older
1111: 1076: 1041: 976: 910: 848: 811: 367: 197: 1188: 418: 417:
DRB1*12:DQA1*0505:DQBA1*0301 haplotype: DR12-DQ7.5/DR7-DQ2.2 is a transhaplotype risk for
171: 152: 1045: 981: 964: 1370: 1080: 852: 816: 799: 246:
DR12, DR5 and DR11 serotype recognition of the gene products of some DRB1*12 alleles
1115: 777: 393: 1123: 1018: 990: 914: 860: 825: 1088: 1053: 949: 922: 887: 244: 1355: 1339: 1323: 1307: 1302: 1297: 1292: 1287: 1282: 1272: 1267: 1214: 1198: 1193: 1183: 468: 234: 226: 1262: 1257: 1252: 1247: 1242: 1237: 1232: 1227: 1222: 1178: 758: 663: 659: 655: 651: 631: 627: 623: 619: 599: 595: 591: 587: 554: 550: 546: 542: 464: 230: 1203: 1164: 381: 223: 47: 695: 690: 685: 1137: 1133: 38:
DQA*01:DRB1*1201 to DQA*01:DRB1*1203 DQA*01:DRB1*1206
1348: 1332: 1316: 1212: 1171: 29:major histocompatibility complex, class II, DR12 233:serotype group which also contains the similar 1149: 8: 1007:Southeast Asian J. Trop. Med. Public Health 757:HLA-DR12 is genetically linked to DR52 and 649: 617: 585: 540: 462: 189: 42: 1156: 1142: 1134: 980: 815: 439: 27: 18: 770: 7: 841:Seminars in Arthritis and Rheumatism 1046:10.1111/j.1399-0039.1992.tb01965.x 14: 853:10.1016/j.semarthrit.2007.04.004 817:10.1111/j.0022-202X.2005.23905.x 19: 982:10.1093/rheumatology/40.12.1398 738: 737: 721: 720: 704: 703: 699: 694: 689: 684: 681: 648: 616: 584: 571: 539: 533: 530: 527: 524: 455: 452: 449: 446: 366:DR12 is associated with vulval 201: 196: 182: 177: 163: 158: 144: 139: 132: 127: 120: 115: 93: 86: 81: 74: 69: 54: 37: 34: 1: 1116:10.1016/j.humimm.2003.12.005 1081:10.1016/0198-8859(92)90080-7 98: 59: 705:A31(19)-Cw10-B51(5)-DR12(5) 1393: 400:, adult chronic articular 390:antiphospholipid syndrome 722:A11-Cw9-B75(15)-DR12(5) 370:, and undifferentiated 915:10.1002/art.1780380925 969:Rheumatology (Oxford) 778:derived from IMGT/HLA 938:Clin. Exp. Rheumatol 398:rheumatoid arthritis 380:is associated with 362:Disease associations 739:A2-Cw10-B13-DR12(5) 247: 386:juvenile arthritis 245: 170:2011-05-15 at the 151:2011-05-15 at the 35:Haplotypes groups 1377:HLA-DR haplotypes 1364: 1363: 804:J Invest Dermatol 755: 754: 428:colorectal cancer 372:spondyloarthritis 348: 347: 213: 212: 1384: 1349:Serotype of DRB5 1333:Serotype of DRB4 1317:Serotype of DRB3 1158: 1151: 1144: 1135: 1128: 1127: 1099: 1093: 1092: 1064: 1058: 1057: 1029: 1023: 1022: 1001: 995: 994: 984: 975:(12): 1398–404. 960: 954: 953: 933: 927: 926: 898: 892: 891: 871: 865: 864: 836: 830: 829: 819: 795: 789: 786: 780: 775: 437: 413:Extended linkage 368:lichen sclerosus 248: 23: 16: 1392: 1391: 1387: 1386: 1385: 1383: 1382: 1381: 1367: 1366: 1365: 1360: 1344: 1328: 1312: 1208: 1167: 1162: 1132: 1131: 1101: 1100: 1096: 1066: 1065: 1061: 1034:Tissue Antigens 1031: 1030: 1026: 1003: 1002: 998: 962: 961: 957: 935: 934: 930: 903:Arthritis Rheum 900: 899: 895: 873: 872: 868: 838: 837: 833: 797: 796: 792: 787: 783: 776: 772: 767: 442: 441:DR12 Haplotypes 435: 433:Genetic Linkage 424:DRB1*1201:DRB3* 419:coeliac disease 415: 402:Still's disease 396:intolerance in 364: 356: 243: 172:Wayback Machine 153:Wayback Machine 111: 65: 30: 12: 11: 5: 1390: 1388: 1380: 1379: 1369: 1368: 1362: 1361: 1359: 1358: 1352: 1350: 1346: 1345: 1343: 1342: 1336: 1334: 1330: 1329: 1327: 1326: 1320: 1318: 1314: 1313: 1311: 1310: 1305: 1300: 1295: 1290: 1285: 1280: 1275: 1270: 1265: 1260: 1255: 1250: 1245: 1240: 1235: 1230: 1225: 1219: 1217: 1210: 1209: 1207: 1206: 1201: 1196: 1191: 1186: 1181: 1175: 1173: 1169: 1168: 1163: 1161: 1160: 1153: 1146: 1138: 1130: 1129: 1094: 1059: 1024: 996: 955: 928: 893: 866: 847:(3): 198–201. 831: 790: 781: 769: 768: 766: 763: 753: 752: 749: 746: 743: 740: 736: 735: 732: 729: 726: 723: 719: 718: 715: 712: 709: 706: 702: 701: 698: 693: 688: 683: 679: 678: 676: 673: 670: 667: 647: 646: 644: 641: 638: 635: 615: 614: 612: 609: 606: 603: 583: 582: 580: 577: 574: 570: 569: 567: 564: 561: 558: 538: 537: 535: 532: 529: 526: 522: 521: 519: 516: 513: 509: 508: 506: 503: 500: 496: 495: 493: 490: 487: 483: 482: 480: 477: 474: 471: 460: 459: 457: 454: 451: 448: 444: 443: 440: 434: 431: 414: 411: 363: 360: 355: 352: 346: 345: 342: 340: 338: 335: 331: 330: 327: 325: 323: 320: 316: 315: 312: 310: 308: 305: 301: 300: 297: 294: 291: 288: 284: 283: 280: 277: 274: 271: 267: 266: 263: 260: 257: 252: 242: 239: 211: 210: 200: 194: 193: 187: 186: 181: 175: 174: 162: 156: 155: 143: 137: 136: 131: 125: 124: 119: 113: 112: 99: 97: 91: 90: 85: 79: 78: 73: 67: 66: 60: 58: 52: 51: 40: 39: 36: 32: 31: 28: 25: 24: 13: 10: 9: 6: 4: 3: 2: 1389: 1378: 1375: 1374: 1372: 1357: 1354: 1353: 1351: 1347: 1341: 1338: 1337: 1335: 1331: 1325: 1322: 1321: 1319: 1315: 1309: 1306: 1304: 1301: 1299: 1296: 1294: 1291: 1289: 1286: 1284: 1281: 1279: 1276: 1274: 1271: 1269: 1266: 1264: 1261: 1259: 1256: 1254: 1251: 1249: 1246: 1244: 1241: 1239: 1236: 1234: 1231: 1229: 1226: 1224: 1221: 1220: 1218: 1216: 1211: 1205: 1202: 1200: 1197: 1195: 1192: 1190: 1187: 1185: 1182: 1180: 1177: 1176: 1174: 1170: 1166: 1159: 1154: 1152: 1147: 1145: 1140: 1139: 1136: 1125: 1121: 1117: 1113: 1109: 1105: 1098: 1095: 1090: 1086: 1082: 1078: 1074: 1070: 1063: 1060: 1055: 1051: 1047: 1043: 1039: 1035: 1028: 1025: 1020: 1016: 1013:(2): 357–65. 1012: 1008: 1000: 997: 992: 988: 983: 978: 974: 970: 966: 959: 956: 951: 947: 944:(3): 249–54. 943: 939: 932: 929: 924: 920: 916: 912: 909:(9): 1340–1. 908: 904: 897: 894: 889: 885: 882:(1): 159–64. 881: 877: 870: 867: 862: 858: 854: 850: 846: 842: 835: 832: 827: 823: 818: 813: 809: 805: 801: 794: 791: 785: 782: 779: 774: 771: 764: 762: 760: 750: 747: 744: 741: 733: 730: 727: 724: 716: 713: 710: 707: 697: 692: 687: 680: 677: 674: 671: 668: 665: 661: 657: 653: 645: 642: 639: 636: 633: 629: 625: 621: 613: 610: 607: 604: 601: 597: 593: 589: 581: 578: 575: 572: 568: 565: 562: 559: 556: 552: 548: 544: 536: 523: 520: 517: 514: 511: 510: 507: 504: 501: 498: 497: 494: 491: 488: 485: 484: 481: 478: 475: 472: 470: 466: 461: 458: 445: 438: 432: 430: 429: 425: 421: 420: 412: 410: 408: 404: 403: 399: 395: 391: 387: 383: 379: 375: 373: 369: 361: 359: 353: 351: 343: 341: 339: 336: 333: 332: 328: 326: 324: 321: 318: 317: 313: 311: 309: 306: 303: 302: 298: 295: 292: 289: 286: 285: 281: 278: 275: 272: 269: 268: 264: 261: 258: 256: 253: 250: 249: 240: 238: 236: 232: 228: 225: 221: 217: 209: 208: 204: 199: 195: 192: 188: 185: 180: 176: 173: 169: 166: 161: 157: 154: 150: 147: 142: 138: 135: 130: 126: 123: 118: 114: 110: 107: 103: 96: 92: 89: 84: 80: 77: 72: 68: 64: 57: 53: 49: 45: 41: 33: 26: 22: 17: 1277: 1172:Genetic loci 1110:(3): 270–6. 1107: 1104:Hum. Immunol 1103: 1097: 1075:(1): 19–23. 1072: 1068: 1062: 1037: 1033: 1027: 1010: 1006: 999: 972: 968: 958: 941: 937: 931: 906: 902: 896: 879: 875: 869: 844: 840: 834: 810:(5): 895–9. 807: 803: 793: 784: 773: 756: 423: 422: 416: 406: 405: 377: 376: 365: 357: 349: 254: 218:(DR12) is a 215: 214: 205: 190: 108: 105: 101: 94: 62: 55: 43: 1069:Hum Immunol 1040:(2): 90–7. 876:J Rheumatol 761:serotypes. 191:Shared data 95:Identifiers 56:Identifiers 765:References 682:Serotypes 525:Serotypes 447:Serotypes 388:, primary 237:antigens. 1215:Serotypes 407:DRB1*1202 394:tiopronin 378:DRB1*1201 282:size (N) 184:DRB1*1306 165:DRB1*1203 146:DRB1*1202 134:DRB1*1201 117:Symbol(s) 71:Symbol(s) 44:Structure 1371:Category 1199:HLA-DRB5 1194:HLA-DRB4 1189:HLA-DRB3 1184:HLA-DRB1 1124:15041167 1019:17124999 991:11752512 861:17604825 826:16297186 788:DR8 - 2% 241:Serology 235:HLA-DR11 227:serotype 216:HLA-DR12 168:Archived 149:Archived 122:HLA-DRB1 88:DRA*0101 1179:HLA-DRA 1089:1356954 1054:1357780 950:7915222 923:7575732 888:8151573 759:HLA-DQ7 426:01/03: 354:Alleles 265:Sample 231:HLA-DR5 207:6p21.31 179:EBI-HLA 160:EBI-HLA 141:EBI-HLA 129:EBI-HLA 100:beta 1 83:EBI-HLA 76:HLA-DRA 1204:HLA-DR 1165:HLA DR 1122:  1087:  1052:  1017:  989:  948:  921:  886:  859:  824:  751:*1202 734:*1202 717:*1202 382:iritis 337:>50 322:>50 270:allele 61:alpha 48:HLA-DR 1213:DRB1 748:*1301 745:*0304 742:*0201 731:*1502 728:*0303 725:*1101 714:*5101 711:*0304 708:*3101 700:DRB1 696:HLA-B 691:HLA-C 686:HLA-A 675:*0301 672:*0601 669:*1201 650:DR12( 643:*0301 640:*0401 637:*1201 618:DR12( 611:*0301 608:*0303 605:*1201 586:DR12( 579:*0301 576:*0505 573:*1202 566:*0301 563:*0505 560:*1201 541:DR12( 518:*0301 515:*1202 512:*0101 505:*0202 502:*1202 499:*0101 492:*0201 489:*1202 486:*0101 479:*0101 476:*1201 473:*0101 463:DR11( 299:893 251:DRB1* 203:chr.6 198:Locus 109:*1206 106:*1203 102:*1201 63:*0101 46:(See 1356:DR51 1340:DR53 1324:DR52 1308:DR18 1303:DR17 1298:DR16 1293:DR15 1288:DR14 1283:DR13 1278:DR12 1273:DR11 1268:DR10 1120:PMID 1085:PMID 1050:PMID 1015:PMID 987:PMID 946:PMID 919:PMID 884:PMID 857:PMID 822:PMID 534:DQB1 531:DQA1 528:DRB1 469:DR52 456:DRB3 453:DRB1 384:in 334:1206 319:1203 314:162 304:1202 287:1201 262:DR11 255:DR12 1263:DR9 1258:DR8 1253:DR7 1248:DR6 1243:DR5 1238:DR4 1233:DR3 1228:DR2 1223:DR1 1112:doi 1077:doi 1042:doi 977:doi 911:doi 849:doi 812:doi 808:125 660:7.6 656:DQ7 628:7.4 624:DQ7 596:7.3 592:DQ7 551:7.5 547:DQ7 450:DRA 392:, 259:DR5 220:HLA 104:to 1373:: 1118:. 1108:65 1106:. 1083:. 1073:34 1071:. 1048:. 1038:40 1036:. 1011:37 1009:. 985:. 973:40 971:. 967:. 942:12 940:. 917:. 907:38 905:. 880:21 878:. 855:. 845:37 843:. 820:. 806:. 802:. 666:) 662:, 654:)- 634:) 630:, 622:)- 602:) 598:, 590:)- 557:) 553:, 545:)- 467:)- 374:. 344:2 329:3 307:89 290:83 224:DR 50:) 1157:e 1150:t 1143:v 1126:. 1114:: 1091:. 1079:: 1056:. 1044:: 1021:. 993:. 979:: 952:. 925:. 913:: 890:. 863:. 851:: 828:. 814:: 664:3 658:( 652:5 632:3 626:( 620:5 600:3 594:( 588:5 555:3 549:( 543:5 465:5 296:2 293:4 279:% 276:% 273:% 222:-

Index

Illustration of an HLA-DR (Human MHC class II) antigen receptor with bound antigen
HLA-DR
Symbol(s)
HLA-DRA
EBI-HLA
DRA*0101
Symbol(s)
HLA-DRB1
EBI-HLA
DRB1*1201
EBI-HLA
DRB1*1202
Archived
Wayback Machine
EBI-HLA
DRB1*1203
Archived
Wayback Machine
EBI-HLA
DRB1*1306
Locus
chr.6
6p21.31
HLA
DR
serotype
HLA-DR5
HLA-DR11
lichen sclerosus
spondyloarthritis

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