222:
DRB4 locus is only apparent in a small subset of DQ haplotypes, and most individuals lack DRB4. In addition the level of normal expression is 8 fold lower than the DRB1 in cells which can express both. and lowered because of both transcriptional and post-transcriptional regulation.
23:
878:
Kobayashi H, Kokubo T, Takahashi M, Sato K, Miyokawa N, Kimura S, Kinouchi R, Katagiri M (1998). "Tyrosinase epitope recognized by an HLA-DR-restricted T-cell line from a Vogt-Koyanagi-Harada disease patient".
701:
Terauchi M, Yanagawa T, Ishikawa N, Ito K, Fukazawa T, Maruyama H, Saruta T (2003). "Interactions of HLA-DRB4 and CTLA-4 genes influence thyroid function in
Hashimoto's thyroiditis in Japanese population".
790:"HLA DRB4 0101-restricted immunodominant T cell autoepitope of pyruvate dehydrogenase complex in primary biliary cirrhosis: evidence of molecular mimicry in human autoimmune diseases"
745:
Zamani M, Spaepen M, Sghar S, Huang C, Westerhof W, Nieuweboer-Krobotova L, Cassiman J (2001). "Linkage and association of HLA class II genes with vitiligo in a Dutch population".
22:
839:"The major histocompatibility complex region marked by HSP70-1 and HSP70-2 variants is associated with clozapine-induced agranulocytosis in two different ethnic groups"
674:
Morling N, Andersen V, Fugger L, et al. (1991). "Immunogenetics of rheumatoid arthritis and primary Sjögren's syndrome: DNA polymorphism of HLA class II genes".
398:
Gorski J, Rollini P, Mach B (1987). "Structural comparison of the genes of two HLA-DR supertypic groups: the loci encoding DRw52 and DRw53 are not truly allelic".
631:
Morita K, Moriuchi J, Inoko H, Tsuji K, Arimori S (1991). "HLA class II antigens and DNA restriction fragment length polymorphism in myasthenia gravis in Japan".
215:
DRB3, DRB4, and DRB5 are minor DR beta encoding loci, they have been recognized as having distinct evolution. and the DRB4 locus presence is linked to
940:
343:
219:
seropositivity. The DRB4*locus was apparently duplicated from an ancestor of the DRB1-DRB4 common locus around 5 million years ago.
168:
156:
144:
132:
84:
523:
Leen MP, Gorski J (1996). "Differential expression of isomorphic HLA-DR beta genes is not a sole function of transcription".
604:
Kobayashi K, Atoh M, Yagita A, et al. (1990). "Crohn's disease in the
Japanese is associated with the HLA-DRw53".
339:
212:
serotype that recognizes gene products of HLA-DRB4 locus. There are 13 alleles at this locus that encode 7 proteins.
1161:
933:
327:
335:
120:
72:
569:
Lepage V, Douay C, Mallet C, et al. (1988). "Erythema multiforme is associated to HLA-Aw33 and DRw53".
77:
926:
125:
324:
192:
855:
838:
354:
HLA-DR53 serotypes (HLA-DRB4) is linked to the following HLADR serotypes (HLA-DRB1) allele groups:
312:
196:
904:
770:
727:
656:
423:
173:
161:
149:
137:
17:
316:
89:
896:
860:
819:
762:
719:
683:
648:
613:
586:
540:
505:
464:
415:
320:
888:
850:
809:
801:
754:
711:
640:
578:
532:
495:
454:
407:
187:
973:
814:
789:
582:
837:
Corzo D, Yunis J, Salazar M, Lieberman J, Howard A, Awdeh Z, Alper C, Yunis E (1995).
1155:
758:
536:
774:
660:
484:"HLA-DRB1 and -DRB4 genes are differentially regulated at the transcriptional level"
427:
908:
731:
459:
442:
500:
483:
300:
557:
805:
766:
723:
900:
892:
864:
823:
687:
652:
644:
617:
590:
544:
509:
468:
419:
1140:
1108:
1092:
1087:
1082:
1077:
1072:
1067:
1062:
1057:
1052:
999:
983:
978:
968:
331:
230:
1047:
1042:
1037:
1032:
1027:
1022:
1017:
1012:
1007:
963:
715:
411:
375:
366:
357:
216:
988:
949:
209:
49:
40:
DRA*01:DRB4*0101 DRA*01:DRB4*0102 DRA*01:DRB4*0103 DRA*01:DRB4*0104
788:
Shimoda S, Nakamura M, Ishibashi H, Hayashida K, Niho Y (1995).
922:
443:"Genetic diversity at class II DRB loci of the primate MHC"
918:
441:
Gyllensten U, Sundvall M, Ezcurra I, Erlich HA (1991).
1133:
1117:
1101:
997:
956:
31:major histocompatibility complex, class II, DR53
856:10.1182/blood.V86.10.3835.bloodjournal86103835
934:
8:
179:
44:
941:
927:
919:
297:Unknown reactivity: *0102, *0104 to *0107
854:
813:
499:
458:
303:: *0101102N, *01030102N, *0201N, *0301N
294:DR53 reactive alleles: DRB4*0101, *0103
29:
20:
482:Stunz LL, Karr RW, Anderson RA (1989).
390:
232:DR53 recognition of some DRB4* alleles
311:DRB4*01 is positively associated with
7:
583:10.1111/j.1399-0039.1988.tb01654.x
14:
340:clozapine-induced agranulocytosis
759:10.1046/j.1365-2133.2001.04288.x
21:
191:
186:
172:
167:
160:
155:
148:
143:
136:
131:
124:
119:
95:
88:
83:
76:
71:
56:
39:
36:
1:
537:10.1016/0198-8859(96)00154-1
460:10.4049/jimmunol.146.12.4368
344:Vogt–Koyanagi–Harada disease
100:
61:
501:10.4049/jimmunol.143.9.3081
1178:
336:primary biliary cirrhosis
328:Hashimoto's thyroiditis
806:10.1084/jem.181.5.1835
606:Exp. Clin. Immunogenet
893:10.1007/s002510050375
645:10.1002/ana.410290209
558:derived from IMGT/HLA
325:rheumatoid arthritis
704:J Endocrinol Invest
313:Erythema multiforme
307:Associated diseases
233:
716:10.1007/bf03349159
412:10.1007/BF00396106
231:
1162:HLA-DR haplotypes
1149:
1148:
321:myasthenia gravis
292:
291:
203:
202:
1169:
1134:Serotype of DRB5
1118:Serotype of DRB4
1102:Serotype of DRB3
943:
936:
929:
920:
913:
912:
875:
869:
868:
858:
834:
828:
827:
817:
785:
779:
778:
742:
736:
735:
698:
692:
691:
671:
665:
664:
628:
622:
621:
601:
595:
594:
566:
560:
555:
549:
548:
520:
514:
513:
503:
479:
473:
472:
462:
438:
432:
431:
395:
350:HLA-DRB1 linkage
234:
25:
18:
1177:
1176:
1172:
1171:
1170:
1168:
1167:
1166:
1152:
1151:
1150:
1145:
1129:
1113:
1097:
993:
952:
947:
917:
916:
877:
876:
872:
849:(10): 3835–40.
836:
835:
831:
787:
786:
782:
744:
743:
739:
710:(12): 1208–12.
700:
699:
695:
673:
672:
668:
630:
629:
625:
603:
602:
598:
571:Tissue Antigens
568:
567:
563:
556:
552:
522:
521:
517:
481:
480:
476:
453:(12): 4368–76.
440:
439:
435:
397:
396:
392:
387:
352:
317:Crohn's disease
309:
229:
115:
67:
32:
12:
11:
5:
1175:
1173:
1165:
1164:
1154:
1153:
1147:
1146:
1144:
1143:
1137:
1135:
1131:
1130:
1128:
1127:
1121:
1119:
1115:
1114:
1112:
1111:
1105:
1103:
1099:
1098:
1096:
1095:
1090:
1085:
1080:
1075:
1070:
1065:
1060:
1055:
1050:
1045:
1040:
1035:
1030:
1025:
1020:
1015:
1010:
1004:
1002:
995:
994:
992:
991:
986:
981:
976:
971:
966:
960:
958:
954:
953:
948:
946:
945:
938:
931:
923:
915:
914:
887:(5): 398–403.
881:Immunogenetics
870:
829:
800:(5): 1835–45.
780:
737:
693:
666:
623:
596:
561:
550:
515:
474:
433:
406:(6): 397–402.
400:Immunogenetics
389:
388:
386:
383:
351:
348:
308:
305:
290:
289:
286:
284:
281:
277:
276:
273:
271:
268:
264:
263:
260:
257:
254:
250:
249:
246:
243:
238:
228:
225:
201:
200:
190:
184:
183:
177:
176:
171:
165:
164:
159:
153:
152:
147:
141:
140:
135:
129:
128:
123:
117:
116:
101:
99:
93:
92:
87:
81:
80:
75:
69:
68:
62:
60:
54:
53:
42:
41:
38:
34:
33:
30:
27:
26:
13:
10:
9:
6:
4:
3:
2:
1174:
1163:
1160:
1159:
1157:
1142:
1139:
1138:
1136:
1132:
1126:
1123:
1122:
1120:
1116:
1110:
1107:
1106:
1104:
1100:
1094:
1091:
1089:
1086:
1084:
1081:
1079:
1076:
1074:
1071:
1069:
1066:
1064:
1061:
1059:
1056:
1054:
1051:
1049:
1046:
1044:
1041:
1039:
1036:
1034:
1031:
1029:
1026:
1024:
1021:
1019:
1016:
1014:
1011:
1009:
1006:
1005:
1003:
1001:
996:
990:
987:
985:
982:
980:
977:
975:
972:
970:
967:
965:
962:
961:
959:
955:
951:
944:
939:
937:
932:
930:
925:
924:
921:
910:
906:
902:
898:
894:
890:
886:
882:
874:
871:
866:
862:
857:
852:
848:
844:
840:
833:
830:
825:
821:
816:
811:
807:
803:
799:
795:
791:
784:
781:
776:
772:
768:
764:
760:
756:
752:
748:
747:Br J Dermatol
741:
738:
733:
729:
725:
721:
717:
713:
709:
705:
697:
694:
689:
685:
682:(5): 289–96.
681:
677:
670:
667:
662:
658:
654:
650:
646:
642:
639:(2): 168–74.
638:
634:
627:
624:
619:
615:
611:
607:
600:
597:
592:
588:
584:
580:
576:
572:
565:
562:
559:
554:
551:
546:
542:
538:
534:
531:(2): 111–20.
530:
526:
519:
516:
511:
507:
502:
497:
494:(9): 3081–6.
493:
489:
485:
478:
475:
470:
466:
461:
456:
452:
448:
444:
437:
434:
429:
425:
421:
417:
413:
409:
405:
401:
394:
391:
384:
382:
381:
377:
373:
372:
368:
364:
363:
359:
355:
349:
347:
345:
341:
337:
333:
329:
326:
322:
318:
314:
306:
304:
302:
298:
295:
287:
285:
282:
279:
278:
274:
272:
269:
266:
265:
261:
258:
255:
252:
251:
247:
244:
242:
239:
236:
235:
226:
224:
220:
218:
213:
211:
207:
199:
198:
194:
189:
185:
182:
178:
175:
170:
166:
163:
158:
154:
151:
146:
142:
139:
134:
130:
127:
122:
118:
114:
111:
108:
105:
98:
94:
91:
86:
82:
79:
74:
70:
66:
59:
55:
51:
47:
43:
35:
28:
24:
19:
16:
1124:
957:Genetic loci
884:
880:
873:
846:
842:
832:
797:
793:
783:
750:
746:
740:
707:
703:
696:
679:
676:Dis. Markers
675:
669:
636:
632:
626:
612:(2): 101–8.
609:
605:
599:
577:(3): 170–5.
574:
570:
564:
553:
528:
525:Hum. Immunol
524:
518:
491:
487:
477:
450:
446:
436:
403:
399:
393:
379:
374:
370:
365:
361:
356:
353:
310:
301:Null alleles
299:
296:
293:
240:
221:
214:
205:
204:
195:
180:
112:
109:
106:
103:
96:
64:
57:
45:
15:
753:(1): 90–4.
633:Ann. Neurol
181:Shared data
97:Identifiers
58:Identifiers
37:Haplotypes
488:J. Immunol
447:J. Immunol
385:References
1000:Serotypes
794:J Exp Med
262:size (N)
174:DRB4*0104
162:DRB4*0103
150:DRB4*0102
138:DRB4*0101
121:Symbol(s)
73:Symbol(s)
46:Structure
1156:Category
984:HLA-DRB5
979:HLA-DRB4
974:HLA-DRB3
969:HLA-DRB1
775:25942367
767:11453913
724:15055474
661:45699820
428:25853147
332:vitiligo
206:HLA-DR53
126:HLA-DRB4
90:DRA*0101
964:HLA-DRA
909:1592923
901:9510558
865:7579351
824:7536796
815:2191998
732:2344535
688:1686751
653:1672809
618:2322470
591:3217933
545:8891734
510:2809218
469:2040804
420:3596674
380:DRB1*09
376:HLA-DR9
371:DRB1*07
367:HLA-DR7
362:DRB1*04
358:HLA-DR4
248:Sample
227:Alleles
217:HLA-DR7
197:6p21.31
169:EBI-HLA
157:EBI-HLA
145:EBI-HLA
133:EBI-HLA
102:beta 4
85:EBI-HLA
78:HLA-DRA
989:HLA-DR
950:HLA DR
907:
899:
863:
822:
812:
773:
765:
730:
722:
686:
659:
651:
616:
589:
543:
508:
467:
426:
418:
253:allele
210:HLA-DR
208:is an
63:alpha
50:HLA-DR
998:DRB1
905:S2CID
843:Blood
771:S2CID
728:S2CID
657:S2CID
424:S2CID
237:DRB4*
193:chr.6
188:Locus
113:*0104
110:*0103
107:*0102
104:*0101
65:*0101
48:(See
1141:DR51
1125:DR53
1109:DR52
1093:DR18
1088:DR17
1083:DR16
1078:DR15
1073:DR14
1068:DR13
1063:DR12
1058:DR11
1053:DR10
897:PMID
861:PMID
820:PMID
763:PMID
720:PMID
684:PMID
649:PMID
614:PMID
587:PMID
541:PMID
506:PMID
465:PMID
416:PMID
280:0103
267:0101
241:DR53
1048:DR9
1043:DR8
1038:DR7
1033:DR6
1028:DR5
1023:DR4
1018:DR3
1013:DR2
1008:DR1
889:doi
851:doi
810:PMC
802:doi
798:181
755:doi
751:145
712:doi
641:doi
579:doi
533:doi
496:doi
492:143
455:doi
451:146
408:doi
288:49
275:38
1158::
903:.
895:.
885:47
883:.
859:.
847:86
845:.
841:.
818:.
808:.
796:.
792:.
769:.
761:.
749:.
726:.
718:.
708:26
706:.
678:.
655:.
647:.
637:29
635:.
608:.
585:.
575:32
573:.
539:.
529:50
527:.
504:.
490:.
486:.
463:.
449:.
445:.
422:.
414:.
404:25
402:.
378:-
369:-
360:-
346:,
342:,
338:,
334:,
330:,
323:,
319:,
315:,
283:89
270:95
52:)
942:e
935:t
928:v
911:.
891::
867:.
853::
826:.
804::
777:.
757::
734:.
714::
690:.
680:9
663:.
643::
620:.
610:7
593:.
581::
547:.
535::
512:.
498::
471:.
457::
430:.
410::
259:%
256:%
245:?
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