568:) arrival from Africa or the Middle East to Central Asia as this best explains the alleles within the haplotype. The A19 (A29, A30, A31, A32, A33, A74) serotypes are very much enriched in sub-saharan and Western Africa, including Iberia, and disequilibrated components of DR7 show a tendency to be linked to A19 serotypes.
531:
is in strong linkage disequilibrium particularly in
Northwestern Europe. The highest frequencies tend to be coastal countries along the Atlantic. The Cw16 allele is undoubtedly derived from Western Africa the diversity and frequency of Cw16 declines away from the along the
21:
552:'s Yayoi migration when most of the Korean contribution occurred. Similarities with Mongol genes suggest that Central and East- Central Asian are the likely source, confirmed by the fact the haplotype is found in
544:
of DR7. The most frequent A-B-DR-DQ haplotypes in Korea are found at ~3/4 the Korean frequencies in Japan, except A33-Cw7-B44-DR7-DQ2, which indicates that DR7 likely spread into
596:
Wongsurawat T, Nakkuntod J, Charoenwongse P, Snabboon T, Sridama V, Hirankarn N (2006). "The association between HLA class II haplotype with Graves' disease in Thai population".
20:
536:
longitudinal line. The level of linkage disequilibration about Cw16 postulates a recent arrival from Africa, and indicates a substantial contribution as far north as
234:
The serological reaction of DR7 is excellent for *0701. The serology of *0703 to *0705 to *0709, and *0711 to *0714 serotypes is unknown. DRB1*0710N is a
649:
121:
82:
329:
126:
87:
540:. The A33-Cw7-B44-DR7 offers the same scenario. This haplotype is found in Korea but not Japan, in fact Japan is an
870:
642:
275:
109:
70:
166:
75:
635:
114:
145:
149:
252:
15:
339:
290:
613:
605:
140:
682:
311:
271:
864:
609:
310:
phenotype (transhaplotype encoded isoform DQαβ) is the primary risk DQ isoform in
235:
584:
533:
528:
617:
527:. There are a few interesting genetics with DR7. The A29-Cw16-B44-DR7-DQ2
180:
849:
833:
817:
801:
796:
791:
786:
781:
776:
771:
766:
761:
708:
692:
687:
677:
565:
553:
541:
524:
517:
367:
319:
315:
182:
DR7 serological recognition of the gene products of some DRB1*07 alleles
756:
751:
741:
736:
731:
726:
721:
716:
672:
537:
521:
422:
402:
303:
697:
658:
307:
298:
170:
47:
561:
557:
549:
545:
454:
449:
444:
322:-DQ7) is a clarifying identifier for the at risk transhaplotype.
631:
173:
serotype that recognizes the DRB1*0701 to *0705 gene products.
564:. There is the possibility that this haplotype is a recent (
627:
29:
human major histocompatibility complex, class II, DR7
842:
826:
810:
706:
665:
328:may be associated with sclerosis/lupus associated
643:
8:
420:
400:
365:
238:. DRB1*0702 nomenclature has been deleted.
132:
42:
650:
636:
628:
342:
27:
18:
577:
7:
251:DR7 is positively associated with
14:
610:10.1111/j.1399-0039.2005.00498.x
19:
497:
496:
480:
479:
463:
462:
458:
453:
448:
443:
440:
419:
399:
393:
390:
387:
384:
377:
374:
371:
358:
355:
352:
349:
144:
139:
125:
120:
113:
108:
93:
86:
81:
74:
69:
54:
37:
34:
516:HLA-DR7 is genetically linked
330:anti-apolipoprotein antibodies
1:
98:
59:
887:
464:A29(19)-Cw16-B44(16)-DR7
498:A33(19)-Cw7-B44(16)-DR7
287:DR7:DQA1*0201:DQB1*0202
276:Chaga's cardiomyopathy
585:derived from IMGT/HLA
282:By extended haplotype
314:. DR7-DQ2/DR5-DQ7 (/
242:Disease associations
520:, and is linked to
481:A30(19)-Cw6-B13-DR7
289:is associated with
183:
253:psoriasis vulgaris
181:
35:Haplotypes groups
871:HLA-DR haplotypes
858:
857:
514:
513:
232:
231:
156:
155:
38:DQA*01:DRB1*0701
878:
843:Serotype of DRB5
827:Serotype of DRB4
811:Serotype of DRB3
652:
645:
638:
629:
622:
621:
593:
587:
582:
340:
184:
23:
16:
886:
885:
881:
880:
879:
877:
876:
875:
861:
860:
859:
854:
838:
822:
806:
702:
661:
656:
626:
625:
598:Tissue Antigens
595:
594:
590:
583:
579:
574:
345:
338:
336:Genetic linkage
291:Graves' disease
284:
270:infection with
261:
259:By Allele group
249:
244:
179:
104:
65:
30:
12:
11:
5:
884:
882:
874:
873:
863:
862:
856:
855:
853:
852:
846:
844:
840:
839:
837:
836:
830:
828:
824:
823:
821:
820:
814:
812:
808:
807:
805:
804:
799:
794:
789:
784:
779:
774:
769:
764:
759:
754:
749:
744:
739:
734:
729:
724:
719:
713:
711:
704:
703:
701:
700:
695:
690:
685:
680:
675:
669:
667:
663:
662:
657:
655:
654:
647:
640:
632:
624:
623:
588:
576:
575:
573:
570:
512:
511:
508:
505:
502:
499:
495:
494:
491:
488:
485:
482:
478:
477:
474:
471:
468:
465:
461:
460:
457:
452:
447:
442:
438:
437:
435:
432:
429:
426:
418:
417:
415:
412:
409:
406:
398:
397:
395:
392:
389:
386:
382:
381:
379:
376:
373:
370:
363:
362:
360:
357:
354:
351:
347:
346:
344:DR7 Haplotypes
343:
337:
334:
312:celiac disease
283:
280:
272:cardiomyopathy
260:
257:
248:
245:
243:
240:
230:
229:
226:
223:
219:
218:
215:
212:
208:
207:
204:
201:
197:
196:
193:
188:
178:
175:
154:
153:
143:
137:
136:
130:
129:
124:
118:
117:
112:
106:
105:
99:
97:
91:
90:
85:
79:
78:
73:
67:
66:
60:
58:
52:
51:
40:
39:
36:
32:
31:
28:
25:
24:
13:
10:
9:
6:
4:
3:
2:
883:
872:
869:
868:
866:
851:
848:
847:
845:
841:
835:
832:
831:
829:
825:
819:
816:
815:
813:
809:
803:
800:
798:
795:
793:
790:
788:
785:
783:
780:
778:
775:
773:
770:
768:
765:
763:
760:
758:
755:
753:
750:
748:
745:
743:
740:
738:
735:
733:
730:
728:
725:
723:
720:
718:
715:
714:
712:
710:
705:
699:
696:
694:
691:
689:
686:
684:
681:
679:
676:
674:
671:
670:
668:
664:
660:
653:
648:
646:
641:
639:
634:
633:
630:
619:
615:
611:
607:
603:
599:
592:
589:
586:
581:
578:
571:
569:
567:
563:
559:
555:
551:
547:
543:
539:
535:
530:
526:
523:
519:
509:
506:
503:
500:
492:
489:
486:
483:
475:
472:
469:
466:
456:
451:
446:
439:
436:
433:
430:
427:
424:
416:
413:
410:
407:
404:
396:
383:
380:
369:
364:
361:
348:
341:
335:
333:
331:
327:
323:
321:
317:
313:
309:
305:
301:
300:
294:
292:
288:
281:
279:
277:
274:(also called
273:
269:
266:is linked to
265:
258:
256:
254:
246:
241:
239:
237:
227:
224:
221:
220:
216:
213:
210:
209:
205:
202:
199:
198:
194:
192:
189:
186:
185:
176:
174:
172:
168:
164:
160:
152:
151:
147:
142:
138:
135:
131:
128:
123:
119:
116:
111:
107:
103:
96:
92:
89:
84:
80:
77:
72:
68:
64:
57:
53:
49:
45:
41:
33:
26:
22:
17:
746:
666:Genetic loci
604:(1): 79–83.
601:
597:
591:
580:
515:
325:
324:
296:
295:
286:
285:
267:
263:
262:
250:
233:
190:
162:
158:
157:
148:
133:
101:
94:
62:
55:
43:
247:By serotype
236:null allele
134:Shared data
95:Identifiers
56:Identifiers
572:References
548:after the
441:Serotypes
385:Serotypes
350:Serotypes
127:DRB1*07:01
709:Serotypes
534:Greenwich
529:haplotype
525:serotypes
425:(9.2, 3)
318:-DQ7 or /
206:size (N)
110:Symbol(s)
88:DRA*01:01
71:Symbol(s)
44:Structure
865:Category
693:HLA-DRB5
688:HLA-DRB4
683:HLA-DRB3
678:HLA-DRB1
618:16451208
566:Holocene
554:Pakistan
542:antinode
518:HLA-DR53
326:DR53-DR7
268:T. cruzi
177:Serology
115:HLA-DRB1
673:HLA-DRA
538:Ireland
264:DRB1*07
225:>30%
195:Sample
165:) is a
159:HLA-DR7
150:6p21.31
122:EBI-HLA
100:beta 1
83:EBI-HLA
76:HLA-DRA
698:HLA-DR
659:HLA DR
616:
510:*0701
493:*0701
476:*0701
405:(2.2)
200:allele
102:*07:01
63:*01:01
61:alpha
48:HLA-DR
707:DRB1
562:India
558:China
550:Japan
546:Korea
507:*4403
504:*0701
501:*3301
490:*1302
487:*0602
484:*3001
473:*4403
470:*1601
467:*2902
459:DRB1
455:HLA-B
450:HLA-C
445:HLA-A
434:*0701
431:*0303
428:*0201
414:*0701
411:*0202
408:*0201
375:*0701
372:*0101
217:7390
187:DRB1*
146:chr.6
141:Locus
46:(See
850:DR51
834:DR53
818:DR52
802:DR18
797:DR17
792:DR16
787:DR15
782:DR14
777:DR13
772:DR12
767:DR11
762:DR10
614:PMID
560:and
421:DR7-
401:DR7-
394:DRB1
391:DQB1
388:DQA1
368:DR53
366:DR7-
359:DRB4
356:DRB1
320:DR12
316:DR11
297:DR7-
222:0704
211:0701
757:DR9
752:DR8
747:DR7
742:DR6
737:DR5
732:DR4
727:DR3
722:DR2
717:DR1
606:doi
522:DQ2
423:DQ9
403:DQ2
378:*01
353:DRA
308:DQ7
304:DR5
299:DQ2
278:).
191:DR7
167:HLA
163:DR7
867::
612:.
602:67
600:.
556:,
332:.
293:.
255:.
228:1
214:99
171:DR
50:)
651:e
644:t
637:v
620:.
608::
306:-
302:/
203:%
169:-
161:(
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