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Woltering TJ, Adam G, Huguenin P, Wichmann J, Kolczewski S, Gatti S, Bourson A, Kew JN, Richards G, Kemp JA, Mutel V, Knoflach F (February 2008). "Asymmetric synthesis and receptor pharmacology of the group II mGlu receptor ligand (1S,2R,3R,5R,6S)-2-amino-3-hydroxy-bicyclohexane-2,6-dicarboxylic
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Lundström L, Kuhn B, Beck J, Borroni E, Wettstein JG, Woltering TJ, Gatti S (July 2009). "Mutagenesis and molecular modeling of the orthosteric binding site of the mGlu2 receptor determining interactions of the group II receptor antagonist (3)H-HYDIA".
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is a drug that is used in neuroscience research, which acts as a potent and selective antagonist for the group II metabotropic glutamate receptors (
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InChI=1S/C8H11NO5/c9-8(7(13)14)3(10)1-2-4(5(2)8)6(11)12/h2-5,10H,1,9H2,(H,11,12)(H,13,14)/t2-,3+,4-,5-,8-/m0/s1
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306:. HYDIA is similar in structure to group II mGluR
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1458:Glutamate metabolism/transport modulators
1365:Tooltip Metabotropic glutamate receptor 8
1266:Tooltip Metabotropic glutamate receptor 7
1194:Tooltip Metabotropic glutamate receptor 6
1090:Tooltip Metabotropic glutamate receptor 4
941:Tooltip Metabotropic glutamate receptor 3
783:Tooltip Metabotropic glutamate receptor 2
597:Tooltip Metabotropic glutamate receptor 5
483:Tooltip Metabotropic glutamate receptor 1
1454:Ionotropic glutamate receptor modulators
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997:Pomaglumetad methionil (LY-2140023)
849:Pomaglumetad methionil (LY-2140023)
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1495:. You can help Knowledge (XXG) by
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1393:Positive allosteric modulators:
1344:Negative allosteric modulators:
1133:Positive allosteric modulators:
1051:Negative allosteric modulators:
915:Negative allosteric modulators:
858:Positive allosteric modulators:
714:Negative allosteric modulators:
657:Positive allosteric modulators:
455:Metabotropic glutamate receptor
264:Key:NTPXNEQCDPWJQA-AZDHXYLBSA-N
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1547:MGlu3 receptor antagonists
1542:MGlu2 receptor antagonists
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158:Chemical and physical data
1562:Nervous system drug stubs
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982:LY-404,039 (pomaglumetad)
829:LY-404,039 (pomaglumetad)
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239:C12(2(1O)(C(=O)O)N)C(=O)O
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1487:article relating to the
861:JNJ-40411813 (ADX-71149)
398:10.1002/cmdc.200700226
354:10.1002/cmdc.200900028
320:competitive antagonist
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1557:Bicyclic compounds
304:molecular modeling
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218:Interactive image
127:CompTox Dashboard
16:Chemical compound
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392:(2): 323–35.
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1497:expanding it
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1403:Antagonists:
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1302:Antagonists:
1301:
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1220:Antagonists:
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1148:Antagonists:
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1009:Antagonists:
1008:
1002:Talaglumetad
948:
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868:Antagonists:
867:
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854:Talaglumetad
790:
727:Dipraglurant
722:Basimglurant
713:
667:Antagonists:
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546:Antagonists:
545:
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316:pomaglumetad
292:
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1129:VU-0155,041
1054:Decoglurant
918:Decoglurant
752:Raseglurant
700:Remeglurant
685:Mavoglurant
549:BAY 36-7620
386:ChemMedChem
342:ChemMedChem
201: g·mol
71:259134-85-5
36:Identifiers
1536:Categories
1396:AZ12216052
1136:Foliglurax
1124:VU-001,171
1037:LY-341,495
1032:LY-307,452
987:LY-487,379
977:LY-379,268
896:LY-341,495
891:LY-307,452
839:LY-566,332
834:LY-487,379
824:LY-379,268
680:LY-344,545
660:LSN2463359
569:LY-456,236
564:LY-367,385
458:modulators
326:References
206:3D model (
194:Molar mass
107:ChemSpider
62:CAS Number
45:IUPAC name
1447:See also:
1381:Glutamate
1373:Agonists:
1295:LSP2-9166
1282:Glutamate
1274:Agonists:
1205:Glutamate
1202:Agonists:
1114:LSP2-9166
1101:Glutamate
1098:Agonists:
1073:Group III
1059:RO4491533
967:Glutamate
962:Eglumegad
949:Agonists:
923:RO4491533
814:Glutamate
809:Eglumegad
791:Agonists:
638:Glutamate
613:ADX-47273
605:Agonists:
529:Ro67-7476
524:Ro67-4853
519:Ro01-6128
504:Glutamate
491:Agonists:
312:eglumetad
1431:UBP-1112
1347:ADX71743
1335:UBP-1112
1248:UBP-1112
1176:UBP-1112
1047:MGS-0039
992:MGS-0028
906:MGS-0039
844:MGS-0028
766:Group II
710:SIB-1893
705:SIB-1757
695:NPS-2390
579:NPS-2390
539:Theanine
406:18058780
362:19402024
310:such as
308:agonists
283:(verify)
737:GRN-529
732:Fenobam
717:AZD9272
653:VU-1545
554:CPCCOEt
466:Group I
414:1695024
370:9062937
199:201.178
164:Formula
116:7969990
96:9794223
82:PubChem
1340:XAP044
1277:AMN082
957:DCG-IV
952:CBiPES
911:PCCG-4
804:DCG-IV
799:CBiPES
412:
404:
368:
360:
232:SMILES
1491:is a
1483:This
1358:mGluR
1315:MMPIP
1259:mGluR
1187:mGluR
1119:PHCCC
1083:mGluR
1027:HYDIA
1017:CECXG
1012:APICA
934:mGluR
886:HYDIA
876:CECXG
871:APICA
776:mGluR
675:DMeOB
618:CDPPB
590:mGluR
534:VU-71
476:mGluR
410:S2CID
366:S2CID
297:mGluR
293:HYDIA
252:InChI
208:JSmol
21:HYDIA
1493:stub
1485:drug
1426:MTPG
1421:MSOP
1416:MPPG
1411:MAP4
1406:CPPG
1389:-AP4
1376:DCPG
1330:MTPG
1325:MSOP
1320:MPPG
1310:MAP4
1305:CPPG
1290:-AP4
1243:MTPG
1238:MSOP
1233:MPPG
1228:MAP4
1223:CPPG
1213:-AP4
1171:MTPG
1166:MSOP
1161:MPPG
1156:MAP4
1151:CPPG
1141:MPEP
1109:-AP4
1042:MCPG
1022:EGLU
901:MCPG
881:EGLU
794:BINA
747:MTEP
742:MPEP
690:MCPG
670:CTEP
633:DHPG
623:CHPG
608:ACPD
574:MCPG
499:DHPG
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358:PMID
314:and
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299:2/3
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