31:
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helper cells, respectively. Further studies were concerned with the structure and function of the pre-T cell receptor and its role in controlling survival and differentiation of developing T cells that have succeeded in productive TCR beta rearrangement. Harald von
Boehmer studied the generation and
239:
In
February 2013 Harald von Boehmer, MD, PhD, Professor of Microbiology and Immunology at the Department of Cancer Immunology & AIDS, Harvard Medical School (USA), did receive the Helmholtz International Fellow Award for having excelled in the field of Immunology.
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702:
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complexes by transfer of TCR alpha and beta genes from one T cell clone to another. Questions concerned with the role of positive and negative selection of developing T cells by peptide-MHC complexes in the
196:
in generating an effective and self-tolerant immune system were analyzed in TCR transgenic mice. The same experimental system served the purpose to study the impact of TCR-ligation on developing T cells by
214:
function of regulatory T cells that have an essential role in preventing autoimmunity with the goal to exploit these cells in the prevention of and interference with unwanted immune reactions.
488:
Nat. Immunol. 6, 1219-1227 (2005). Marson, A.°, Kretschmer, K.°, Frampton, G. M., Jacobsen, E. S., Polansky, J., MacIsaac, K. D., Levine, S. S., Fraenkel, E., von
Boehmer, H., Young, R. A.:
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Pre-TCR-mediated feedback on TCRbeta rearrangement as essential mechanism for TCRbeta allelic exclusion. Lack of TCRalpha allelic exclusion.
814:
539:
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Graft-versus-host disease-free allogeneic bone marrow transplantation after T cell removal (used later to cure human immunodeficiency).
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T cell memory rests with memory cells that differ in phenotype and function from naive T cells and survive in the absence of antigen.
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The generation of mature T cells requires an interaction of the alpha beta T cell receptor with major histocompatibility antigens.
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Nat. Immunol. 3, 756-63 (2002); Kretschmer, K., Apostolou, I., Hawiger, D., Khazaie, K-, Nussenzweig, M. C. and von
Boehmer, H.:
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A novel disulfide-linked heterodimer on pre-T cells consists of the T cell receptor beta chain and a 33 kd glycoprotein.
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Essential role of T cell receptor-mediated positive selection in T cell survival and lineage fate (CD4/8) determination.
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Allo-MHC-restricted CD4 and CD8 T cells in hemopoietic chimeras reveal plasticity of MHC-restricted antigen recognition.
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Von
Boehmer studied the role of T lymphocytes in the immune system. In particular he addressed the contribution of the
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Cell 75, 283-294 (1993); Saint-Ruf, C., Ungewiss, K., Groettrup, M., Bruno, L., Fehling, H. J. and von
Boehmer, H.:
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Harald von
Boehmer was elected as a Senior Member of the Institut Universitaire de France (1997), was awarded the
824:
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Antigen-dependent intra- and extra-thymic generation of regulatory T cells and Foxp3-dependent gene regulation.
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Thymic MHC antigens and the specfficity of the ap T cell receptor determine the CD4/CD6 phenotype of T cells.
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Clonal deletion of immature CD4+8+ thymocytes in suspension culture by extrathymic antigen-presenting cells.
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Collaboration of histo-incompatible T and B lymphocytes using cells from tetraparental bone manow chimeras.
232:
Harald von
Boehmer retired at the end of 2012 and was a guest professor at the Institute for Immunology of
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in Geneva (1990) and received an honorary
Medical Degree from the University of Technology, Munich (2002).
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Transfer of alpha and beta TCR genes shows MHC-restricted antigen recognition by a single receptor.
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Crucial role of the pre-T cell receptor in development of alpha beta but not gamma delta T cells.
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Essential role of the pre-T cell receptor in allelic exclusion of the T cell receptor beta locus.
165:
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Teho H. S., Kisielow, P., Scott, 8., Kishi, H., Uematsu, Y., Blüthmann, H. and von
Boehmer, H.:
696:
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Science 266,1208-1212 (1994); Fehling, H.J., Krotkova, A., Saint-Ruf, C. and von Boehmer, H.:
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Dembic, Z., Haas, W., Weiss, S., McCubrey, J., Kiefer, H., von Boehmer, H. and Steinmetz, M.:
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Nature 333, 742-746 (1988); Swat, W., Ignatowicz, L., von Boehmer, H. and Kisielow, P.:
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Tolerance in T cell receptor transgenic mice: deletion of nonmatare CD4+8+ thymoqttes.
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Tolerance to histocompatibility determinants in tetraparental bone marrow chimeras.
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Nature 335, 229 (1988); Scott, 8., Blüthmann, H., Teh, H. S. and von Boehmer, H.:
30:
613:"Helmholtz International Fellow Award to Boston Immunologist Harald von Boehmer"
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141:
102:
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Kisielow, P., Blüthmann, H., Staerz, U. D., Steinmetz, M. and von Boehmer, H.:
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Foxp3 occupancy and regulation of key target genes during T-cell stimulation.
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Cell 69, 529 (1992); Aifantis, I., Buer, J., von Boehmer, H. and Azogui, O.:
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Cytotoxic T lymphocytes recognize allogeneic toleruted, TNP-conjugated cells.
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Guest professor Harald von Boehmer in the Institute for Immunology in Munich
286:
133:
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Peripheral tolerance by deletion of and reversible anergy in matureT cells.
652:
406:
Central tolerance by deletion of immature T cells in TCR transgenic mice.
649:"Avery-Landsteiner-Prize of the German society for immunology; honorees"
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Transfer of specificity by marine alpha and beta T cell receptor genes.
297:
98:
168:, Cambridge and Chief of the Laboratory for Lymphocyte Biology at the
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145:
109:
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Groettrup, M., Ungewiss, K., Azogui, O., Palacios, R., Owen, M. J.,
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1990 Avery-Landsteiner-Prize of the German society for immunology (
476:
Discovery of the pre-TCR. Cloning and targeting of the Ptcra gene.
436:
Exclusion and inclusion of alpha and beta T cell receptor alleles.
153:
51:
530:
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570:"The American Association of Immunologists - Harald von Boehmer"
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Origin of regulatory T cells with known specificity for antigen.
518:
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331:
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Members of the German National Academy of Sciences Leopoldina
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Inducing and expanding regulatory T cells by foreign antigen.
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Analysis and expression of a cloned pre-T cell receptor gene.
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Apostolou, I., Sarukhan, A., Klein, L. and von Boehmer, H.:
730:"Harald von Boehmer publication list at Harvard University"
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J. Exp. Med. 1421989 (1975); von Boehmer, H. and Haaso W.:
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Borgulya, P., Kishi, H., Uematsu, Y. and von Boehmer, H.:
124:'s three children, von Boehmer obtained an M.D. from the
718:
German Academy of Sciences Leopoldina; membership list
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Louis Jeantet Prize for Medicine 1990; Lauréats (frz.)
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On the cellular basis of immunological T cell memory.
243:
Von Boehmer died on June 24, 2018, at the age of 75.
81:
71:
59:
37:
21:
507:Harald von Boehmer at Cancer Immunology Research
426:Peripheral selection of the T cell repertoire.
362:von Boehmer, H., Sprent, J. and Nabholz, M..:
8:
448:Bruno, L., Kirberg, J. and von Boehmer, H.:
372:von Boehmer, H., Hudson, L. and Sprent, J.:
187:(TCR) to recognition by T cells of peptide-
283:Paul Ehrlich and Ludwig Darmstaedter Prize
18:
775:Academic staff of the University of Basel
534:Harald von Boehmer in the library of the
348:2013 Helmholtz International Fellow Award
205:ligands on the intrathymic generation of
164:and the Faculty of Arts and Sciences of
97:(30 November 1942 – 24 June 2018) was a
550:
820:Swiss expatriates in the United States
234:Ludwig Maximilian University of Munich
126:Ludwig Maximilian University of Munich
108:and author best known for his work on
321:German Academy of Sciences Leopoldina
176:. He was an adjunct professor at the
7:
700:for European Science; honorees 1997
330:2003 National Institutes of Health
14:
160:and is Professor of Pathology at
305:Institut Universitaire de France
254:Louis Jeantet Prize for Medicine
219:Louis-Jeantet Prize for Medicine
86:Louis-Jeantet Prize for Medicine
29:
810:German emigrants to Switzerland
424:Rocha, B. and von Boehmer, H.:
144:(1973–1996), director of Unité
136:(1974). He was a member of the
785:Harvard Medical School faculty
366:J. Exp. Med. 141, 322 (1975).
315:Technical University of Munich
138:Basel Institute for Immunology
1:
780:University of Florida faculty
294:Körber European Science Prize
474:Nature 375, 795-798 (1995).
442:Immunity 7, 601-607 (1997).
343:Sherman Fairchild Foundation
170:Dana Farber Cancer Institute
815:Swiss expatriates in France
524:Deutsche Nationalbibliothek
319:2003 Elected member of the
303:1997 Elected member of the
263:1990 Elected member of the
841:
492:Nature 445, 931-5 (2007).
428:Science 251, 1225 (1991).
452:Immunity 2,37-43 (1995).
313:in Medical degree of the
150:René Descartes University
28:
16:German-Swiss immunologist
800:German untitled nobility
418:Nature 338, 591 (1989).
404:Nature 351, 150 (1991).
390:Nature 329, 232 (1986).
380:Nature 261, 141 (1976).
236:beginning January 2013.
128:(1968) and a Ph.D. from
536:University of Freiburg
522:Harald von Boehmer in
511:Harald von Boehmer in
162:Harvard Medical School
462:and von Boehmer, H.:
357:Selected papers from
353:Selected publications
178:University of Florida
790:German immunologists
697:Kurt A. Körber Prize
130:Melbourne University
795:Swiss immunologists
558:Louis-Jeantet Prize
513:Library of Congress
705:2016-03-06 at the
681:Ludwig Darmstädter
599:2015-10-16 at the
166:Harvard University
95:Harald von Boehmer
23:Harald von Boehmer
770:People from Guben
265:Academia Europaea
223:Nicole Le Douarin
122:Hasso von Boehmer
92:
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48:November 30, 1942
832:
825:Inserm directors
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732:. Archived from
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684:-Prize; honorees
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615:. Archived from
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227:Gottfried Schatz
120:The youngest of
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583:obituary notice
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336:Washington D.C.
311:Honorary doctor
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185:T cell receptor
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738:. Retrieved
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675:Paul Ehrlich
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203:MHC class II
182:
119:
106:immunologist
94:
93:
76:Immunologist
65:(2018-06-24)
765:2018 deaths
760:1942 births
540:[Vorr.]
209:killer and
199:MHC class I
148:373 at the
142:Switzerland
754:Categories
740:2015-10-09
659:2015-10-09
623:2015-10-08
546:References
72:Occupation
44:1942-11-30
287:Frankfurt
134:Australia
54:, Germany
703:Archived
597:Archived
298:Hamburg
110:T cells
678:- and
276:Aachen
269:London
258:Geneva
247:Awards
194:thymus
174:Boston
158:France
146:INSERM
116:Career
99:German
88:(1990)
82:Awards
345:award
341:2004
325:Halle
309:2002
292:1997
281:1993
252:1990
154:Paris
103:Swiss
52:Guben
529:and
225:and
201:and
60:Died
38:Born
332:NIH
211:CD4
207:CD8
189:MHC
172:in
152:in
140:in
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538::
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517:,
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Text is available under the Creative Commons Attribution-ShareAlike License. Additional terms may apply.
