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InChI=1S/C29H32N4O3S/c1-2-37(35,36)32-24-15-16-26-25(19-24)27(29(34)31-26)28(22-9-5-3-6-10-22)30-23-13-11-21(12-14-23)20-33-17-7-4-8-18-33/h3,5-6,9-16,19,30,32H,2,4,7-8,17-18,20H2,1H3,(H,31,34)/b28-27-
234:
InChI=1/C29H32N4O3S/c1-2-37(35,36)32-24-15-16-26-25(19-24)27(29(34)31-26)28(22-9-5-3-6-10-22)30-23-13-11-21(12-14-23)20-33-17-7-4-8-18-33/h3,5-6,9-16,19,30,32H,2,4,7-8,17-18,20H2,1H3,(H,31,34)/b28-27-
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Hauf, Silke; Cole, Richard W.; LaTerra, Sabrina; Zimmer, Christine; Schnapp, Gisela; Walter, Rainer; Heckel, Armin; van Meel, Jacques; Rieder, Conly L. (2003-04-28).
433:"The small molecule Hesperadin reveals a role for Aurora B in correcting kinetochore-microtubule attachment and in maintaining the spindle assembly checkpoint"
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493:"The cell cycle as a therapeutic target againstTrypanosoma brucei: Hesperadin inhibits Aurora kinase-1 and blocks mitotic progression in bloodstream forms"
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Jetton, Neal; Rothberg, Karen G.; Hubbard, James G.; Wise, John; Li, Yan; Ball, Haydn L.; Ruben, Larry (April 2009).
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Hesperadin, like other miotic inhibitors, limits and sometimes can stop the process of mitosis in
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much faster, sometimes before the chromosomes are properly bi-oriented.
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CCS(=O)(=O)NC1=CC2=C(C=C1)NC(=O)C2=C(C3=CC=CC=C3)NC4=CC=C(C=C4)CN5CCCCC5
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403:. For this reason, some have considered hesperadin's potential as a
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Except where otherwise noted, data are given for materials in their
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alignment and segregation by limiting the function of
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227:Key: GLDSKRNGVVYJAB-DQSJHHFOSA-N
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392:. Hesperadin causes cells to enter
237:Key: GLDSKRNGVVYJAB-DQSJHHFOBF
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51:-anilino}methylidene)-2,3-dihydro-1
568:. You can help Knowledge (XXG) by
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509:10.1111/j.1365-2958.2009.06657.x
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328:(at 25 °C , 100 kPa).
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55:-indol-5-yl]ethanesulfonamide
376:The small molecule inhibits
437:The Journal of Cell Biology
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615:Protein kinase inhibitors
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16:Not to be confused with
625:1-Piperidinyl compounds
410:Hesperadin works as an
371:aurora kinase inhibitor
564:-related article is a
497:Molecular Microbiology
449:10.1083/jcb.200208092
44:Preferred IUPAC name
318: g·mol
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635:Pharmacology stubs
407:-preventing drug.
355:Infobox references
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62:Identifiers
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267:Properties
79:422513-13-1
24:Hesperadin
609:Categories
418:References
378:chromosome
367:Hesperadin
311:Molar mass
168:PTR491OS14
114:ChemSpider
90:3D model (
69:CAS Number
18:hesperidin
517:0950-382X
457:0021-9525
412:inhibitor
535:19320832
475:12707311
394:anaphase
390:Aurora A
386:Aurora B
384:kinases
148:10142586
630:Lactams
526:2697958
466:2172906
382:mitotic
348:what is
346: (
135:PubChem
123:8318096
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405:cancer
369:is an
343:verify
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316:516.66
251:SMILES
38:Names
560:This
401:cells
216:InChI
92:JSmol
566:stub
531:PMID
513:ISSN
471:PMID
453:ISSN
388:and
159:UNII
521:PMC
505:doi
461:PMC
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441:161
185:EPA
138:CID
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292:N
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