218:
4115:
28:
186:
200:
172:
914:
Harrington, Elizabeth A.; Bebbington, David; Moore, Jeff; Rasmussen, Richele K.; Ajose-Adeogun, Abi O.; Nakayama, Tomoko; Graham, Joanne A.; Demur, Cecile; Hercend, Thierry; Diu-Hercend, Anita; Su, Michael; Golec, Julian M C.; Miller, Karen M. (2004). "VX-680, a potent and selective small-molecule
361:
Ewart-Toland, Amanda; Briassouli, Paraskevi; De Koning, John P.; Mao, Jian-Hua; Yuan, Jinwei; Chan, Florence; Maccarthy-Morrogh, Lucy; Ponder, Bruce A J.; Nagase, Hiroki; Burn, John; Ball, Sarah; Almeida, Maria; Linardopoulos, Spiros; Balmain, Allan (2003). "Identification of Stk6/STK15 as a
3642:
1016:
1301:
245:
moiety and Aurora-2. Residues Lys-162 and Asp-274 are essential for Aurora-2 kinase activity but do not hydrogen bond to each other as seen in crystal structures of several other protein kinases.
237:. The protein backbone atoms of residues Glu-211, Ala-213 in the hinge region of Aurora-2, and the sidechain of residue Trp-277, located in the activation loop, bind adenosine through specific
3652:
765:"Aurora Kinase Inhibitor ZM447439 Blocks Chromosome-induced Spindle Assembly, the Completion of Chromosome Condensation, and the Establishment of the Spindle Integrity Checkpoint inXenopus
3647:
1009:
816:
Peters, Jan-Michael; Rieder, Conly L.; Van Meel, Jacques; Heckel, Armin; Walter, Rainer; Schnapp, Gisela; Zimmer, Christine; Laterra, Sabrina; Cole, Richard W.; Hauf, Silke (2003).
540:
Goto, Hidemasa; Yasui, Yoshihiro; Nigg, Erich A.; Inagaki, Masaki (2002). "Aurora-B phosphorylates
Histone H3 at serine28 with regard to the mitotic chromosome condensation".
107:, have gained a great deal of attention as possible anticancer drug targets. The Aurora enzymes are particularly significant because they are involved in a direct path to the
3767:
3745:
1002:
1209:
3563:
818:"The small molecule Hesperadin reveals a role for Aurora B in correcting kinetochore–microtubule attachment and in maintaining the spindle assembly checkpoint"
1757:
2596:
1060:
3673:
2705:
1443:
1330:
1718:
3568:
3735:
2691:
2156:
1047:
1029:
2793:
2674:
2380:
1249:
3374:
2444:
1419:
2700:
1234:
165:, although the Phase II clinical trial was suspended in November, 2007 due to QT prolongation observed in one patient in Phase I trial.
4145:
3508:
2757:
2432:
72:
aurora kinase genes, encoding aurora A, B and C. Intense investigation has focused on aurora A and B as they appear to play a role in
3834:
3078:
2872:
1689:
1679:
1364:
225:
The structure and active site of Aurora-2-adenosine complex has been determined. The hinge (yellow), glycine-rich loop (blue), and
3219:
2371:
957:
Graham M. T. et al., Crystal
Structure of Aurora-2, an Oncogenic Serine/Threonine Kinase J. Biol. Chem., (2002) 277: pp.42419-22
2640:
2312:
1674:
1665:
283:
Andrews, Paul D.; Knatko, Elena; Moore, William J.; Swedlow, Jason R. (2003). "Mitotic mechanics: The auroras come into view".
3990:
3792:
3787:
3347:
3165:
2055:
1552:
1543:
1200:
1146:
4105:
318:
Katayama, Hiroshi; Brinkley, W. R.; Sen, S. (2003). "The Aurora kinases: Role in cell transformation and tumorigenesis".
3657:
3545:
3513:
3498:
1243:
3180:
91:
A new approach to inhibiting cancer growth that shows great promise for structure-based drug development is targeting
994:
2267:
2085:
1581:
3975:
4091:
4078:
4065:
4052:
4039:
4026:
4013:
3778:
3756:
3731:
3706:
3626:
3234:
3194:
3139:
3116:
3088:
3056:
2922:
2257:
2252:
2247:
2237:
2232:
2227:
2217:
2012:
1787:
1383:
3985:
3009:
3939:
3882:
3243:
3224:
3155:
2889:
2480:
2471:
2422:
1188:
1033:
3887:
3101:
2780:
2203:
665:
Yang, Hua; Ou, Chien Chen; Feldman, Richard I.; Nicosia, Santo V.; Kruk, Patricia A.; Cheng, Jin Q. (2004).
259:
3555:
3328:
3238:
865:
Sakita-Suto, Shiho; Kanda, Akifumi; Suzuki, Fumio; Sato, Sunao; Takata, Takashi; Tatsuka, Masaaki (2007).
667:"Aurora-A Kinase Regulates Telomerase Activity through c-Myc in Human Ovarian and Breast Epithelial Cells"
158:
3908:
3827:
3409:
3364:
3066:
3051:
2987:
2967:
2865:
1479:
3980:
2850:
3323:
3318:
3198:
3061:
3041:
2950:
2046:
4135:
3944:
3586:
3578:
3359:
3026:
2962:
2926:
988:
264:
2554:
577:"DNA methylation promotes Aurora-B-driven phosphorylation of histone H3 in chromosomal subdomains"
3877:
3449:
3387:
3338:
3073:
2900:
2657:
2611:
940:
745:
696:
606:
522:
473:
430:
387:
343:
3464:
3454:
3444:
3369:
3353:
3312:
3298:
3293:
3031:
2994:
1917:
1626:
932:
896:
847:
798:
737:
688:
647:
598:
557:
514:
465:
422:
379:
335:
300:
405:
Nigg, Erich A. (2001). "Mitotic kinases as regulators of cell division and its checkpoints".
4140:
3923:
3918:
3892:
3820:
3797:
3459:
3439:
3381:
3277:
3175:
3160:
3106:
3004:
2999:
2858:
2510:
1752:
1742:
1737:
1655:
1646:
1576:
1567:
1513:
1504:
1161:
924:
886:
878:
837:
829:
788:
780:
727:
678:
637:
588:
549:
504:
457:
414:
371:
327:
292:
50:
3970:
3954:
3867:
3720:
3710:
3532:
3503:
3129:
3036:
3021:
2336:
1407:
1402:
1397:
624:
Lee, Edmund Chun Yu; Frolov, Anna; Li, Rile; Ayala, Gustavo; Greenberg, Norman M. (2006).
226:
185:
131:
112:
104:
448:
Keen, Nicholas; Taylor, Stephen (2004). "Aurora-kinase inhibitors as anticancer agents".
4119:
4008:
3949:
3688:
3527:
3434:
3426:
3303:
3266:
891:
866:
842:
817:
238:
230:
171:
162:
154:
17:
793:
764:
199:
4129:
3913:
3872:
2957:
1460:
1392:
553:
434:
135:
46:
944:
749:
700:
610:
526:
477:
391:
347:
217:
3862:
3046:
3016:
2945:
2331:
1156:
127:
732:
715:
683:
666:
642:
625:
509:
492:
4086:
4021:
3857:
3612:
3602:
3203:
2940:
2881:
2537:
2169:
2109:
1992:
1912:
1636:
970:
Aurora-A (Serine/threonine-protein kinase 6, AIK, ARK1, AURA, BTAK, STK15, STK6)
73:
61:
32:
4114:
27:
3414:
3257:
3170:
2935:
2885:
2625:
1099:
984:
331:
296:
191:
146:
108:
77:
57:
4060:
4034:
3693:
3606:
3143:
2909:
1586:
882:
784:
234:
119:
69:
936:
900:
851:
802:
741:
692:
651:
602:
561:
518:
469:
426:
383:
339:
304:
833:
3540:
3120:
1942:
1837:
1832:
1827:
177:
142:
123:
362:
candidate low-penetrance tumor-susceptibility gene in mouse and human".
3491:
3476:
3092:
2601:
2579:
2574:
2564:
2559:
2361:
2356:
2351:
2346:
2341:
2326:
2321:
1972:
1937:
1176:
1171:
1166:
241:. There are no hydrogen bonds between the 2'-OH or 3'-OH groups of the
115:
100:
96:
92:
979:
975:
Aurora-B (Serine/threonine-protein kinase 12, AIK2, AIM1, ARK2, STK12)
974:
969:
593:
576:
4073:
3843:
3469:
2904:
2831:
2826:
2821:
2816:
2811:
2806:
2801:
2752:
2747:
2742:
2737:
2732:
2715:
2710:
2584:
2569:
2520:
2515:
2500:
2495:
2490:
2485:
2459:
2454:
2449:
2437:
2415:
2410:
2302:
2277:
1952:
1777:
1772:
1767:
1762:
1747:
1591:
1528:
1523:
1518:
1494:
1320:
1315:
1289:
1284:
1279:
1269:
1264:
1254:
1094:
1025:
418:
254:
242:
205:
150:
65:
42:
461:
928:
915:
inhibitor of the Aurora kinases, suppresses tumor growth in vivo".
375:
4047:
3486:
3481:
3333:
2727:
2720:
2630:
2527:
2427:
2405:
2400:
2395:
2390:
2385:
2297:
2292:
2287:
2282:
2272:
2242:
2222:
2099:
2094:
2075:
2070:
2060:
2036:
2031:
2026:
2002:
1997:
1987:
1982:
1977:
1967:
1947:
1932:
1927:
1922:
1902:
1897:
1887:
1882:
1877:
1872:
1867:
1857:
1852:
1847:
1842:
1822:
1817:
1812:
1807:
1802:
1797:
1782:
1732:
1727:
1621:
1616:
1611:
1606:
1601:
1596:
1557:
1489:
1484:
1433:
1428:
1354:
1349:
1344:
1310:
1302:
3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring) kinase
1104:
1089:
1084:
1079:
1074:
1069:
216:
122:
and overexpressed in various forms of cancerous growth, including
80:
26:
3643:
CDP-diacylglycerol—glycerol-3-phosphate 3-phosphatidyltransferase
3397:
3392:
3288:
3283:
2982:
2977:
2972:
2620:
2547:
2542:
2532:
2505:
2262:
2212:
2193:
2188:
2183:
2178:
2133:
2128:
2123:
2118:
2065:
2021:
1962:
1957:
1907:
1892:
1862:
1792:
1708:
1703:
1698:
1631:
1533:
1474:
1469:
1373:
1339:
1224:
1219:
1214:
1183:
1151:
1139:
1134:
1129:
1119:
1114:
980:
Aurora-C (Serine/threonine-protein kinase 13, AIE2, AIK3, STK13)
3816:
2854:
2778:
2154:
1045:
998:
626:"Targeting Aurora Kinases for the Treatment of Prostate Cancer"
2589:
1124:
1109:
49:
enzymes could be potential targets for novel small-molecule
141:
So far three Aurora-kinase inhibitors have been described:
31:
Aurora case study – six inhibitors and their action during
3812:
161:'s VX-680 (Sausville, 234, last posted on 12/18/06) and
716:"Roles of Aurora Kinases in Mitosis and Tumorigenesis"
4103:
3653:
CDP-diacylglycerol—inositol 3-phosphatidyltransferase
3658:
CDP-diacylglycerol—choline O-phosphatidyltransferase
3999:
3963:
3932:
3901:
3850:
3777:
3755:
3730:
3705:
3686:
3666:
3648:
CDP-diacylglycerol—serine O-phosphatidyltransferase
3635:
3625:
3595:
3577:
3554:
3526:
3425:
3265:
3256:
3233:
3193:
3138:
3115:
3087:
2921:
2897:
2792:
2690:
2673:
2656:
2639:
2610:
2470:
2370:
2311:
2202:
2168:
2108:
2084:
2045:
2011:
1717:
1688:
1664:
1645:
1566:
1542:
1503:
1459:
1442:
1418:
1382:
1363:
1329:
1300:
1233:
1199:
1059:
575:Monier, K.; Mouradian, S.; Sullivan, K. F. (2006).
491:Carvajal, R. D.; Tse, A.; Schwartz, G. K. (2006).
99:. Aurora kinases, so named because the scattered
867:"Aurora-B Regulates RNA Methyltransferase NSUN2"
493:"Aurora Kinases: New Targets for Cancer Therapy"
118:H3. Furthermore, Aurora kinases are known to be
103:spindles generated by mutant forms resemble the
714:Fu, J.; Bian, M.; Jiang, Q.; Zhang, C. (2007).
3828:
2866:
1061:Non-specific serine/threonine protein kinases
1010:
763:Gadea, Bedrick B.; Ruderman, Joan V. (2005).
8:
3674:N-acetylglucosamine-1-phosphate transferase
3564:UTP—glucose-1-phosphate uridylyltransferase
153:. The last is in advanced stages (Phase II
3835:
3821:
3813:
3702:
3632:
3262:
3253:
2918:
2873:
2859:
2851:
2789:
2775:
2165:
2151:
1444:Goodpasture-antigen-binding protein kinase
1056:
1042:
1017:
1003:
995:
3768:serine/threonine-specific protein kinases
3746:serine/threonine-specific protein kinases
3569:Galactose-1-phosphate uridylyltransferase
2157:Serine/threonine-specific protein kinases
1331:(isocitrate dehydrogenase (NADP+)) kinase
1048:Serine/threonine-specific protein kinases
1030:Serine/threonine-specific protein kinases
890:
841:
792:
731:
682:
641:
592:
508:
2692:Receptor protein serine/threonine kinase
83:susceptibility gene in mice and humans.
4110:
2675:Low-density-lipoprotein receptor kinase
275:
167:
41:are a putative drug class for treating
1420:Fas-activated serine/threonine kinase
407:Nature Reviews Molecular Cell Biology
7:
2701:Bone morphogenetic protein receptors
1235:Dephospho-(reductase kinase) kinase
1690:G-protein coupled receptor kinases
76:with aurora A identified as a low
25:
3079:Glucose-1,6-bisphosphate synthase
1680:Beta adrenergic receptor kinase-2
1365:(tyrosine 3-monooxygenase) kinase
157:) of a joint drug development by
4113:
3220:Ribose-phosphate diphosphokinase
2372:Mitogen-activated protein kinase
554:10.1046/j.1356-9597.2001.00498.x
198:
184:
170:
2758:Anti-MĂĽllerian hormone receptor
2641:(acetyl-CoA carboxylase) kinase
2313:(RNA-polymerase)-subunit kinase
1675:Beta adrenergic receptor kinase
1666:Beta adrenergic receptor kinase
285:Current Opinion in Cell Biology
2381:Extracellular signal-regulated
229:(red) are key features of the
1:
3793:Protein-histidine tele-kinase
3788:Protein-histidine pros-kinase
3667:Glycosyl-1-phosphotransferase
2445:P38 mitogen-activated protein
1544:cGMP-dependent protein kinase
1505:cAMP-dependent protein kinase
1201:Pyruvate dehydrogenase kinase
1147:Ataxia telangiectasia mutated
871:Molecular Biology of the Cell
773:Molecular Biology of the Cell
733:10.1158/1541-7786.MCR-06-0208
684:10.1158/0008-5472.can-03-2907
643:10.1158/0008-5472.CAN-05-2796
510:10.1158/1078-0432.CCR-06-1405
320:Cancer and Metastasis Reviews
3499:RNA-dependent RNA polymerase
1244:AMP-activated protein kinase
985:Mitotic spindle & Aurora
3406:RNA-directed DNA polymerase
3274:DNA-directed DNA polymerase
2159:(EC 2.7.11.21-EC 2.7.11.30)
4162:
3759:: protein-dual-specificity
2086:Elongation factor 2 kinase
1050:(EC 2.7.11.1-EC 2.7.11.20)
64:, and thus are targets in
4146:Protein kinase inhibitors
3991:Michaelis–Menten kinetics
2788:
2774:
2481:MAP kinase kinase kinases
2164:
2150:
2013:Myosin light-chain kinase
1719:Ca2+/calmodulin-dependent
1384:Myosin-heavy-chain kinase
1055:
1041:
720:Molecular Cancer Research
297:10.1016/j.ceb.2003.10.013
233:fold involved in binding
68:therapy. There are three
3883:Diffusion-limited enzyme
3736:protein-serine/threonine
3636:Phosphatidyltransferases
3225:Thiamine diphosphokinase
2781:Dual-specificity kinases
497:Clinical Cancer Research
60:transit from G2 through
56:Aurora kinases regulate
39:Aurora kinase inhibitors
2204:Cyclin-dependent kinase
883:10.1091/mbc.e06-11-1021
822:Journal of Cell Biology
785:10.1091/mbc.e04-10-0891
581:Journal of Cell Science
332:10.1023/a:1023789416385
260:Cyclin-dependent kinase
18:Aurora kinase inhibitor
3556:Nucleotidyltransferase
3239:nucleotidyltransferase
3166:Nucleoside-diphosphate
222:
221:Aurora's active center
159:Vertex Pharmaceuticals
35:
3976:Eadie–Hofstee diagram
3909:Allosteric regulation
3410:Reverse transcriptase
834:10.1083/jcb.200208092
450:Nature Reviews Cancer
220:
30:
3986:Lineweaver–Burk plot
3199:diphosphotransferase
3181:Thiamine-diphosphate
2888:-containing groups (
2047:Phosphorylase kinase
95:central to cellular
3781:: protein-histidine
3699:; protein acceptor)
3587:mRNA capping enzyme
3579:Guanylyltransferase
989:The Proteolysis Map
265:Signal transduction
3945:Enzyme superfamily
3878:Enzyme promiscuity
3057:Phosphoinositide 3
2901:phosphotransferase
2658:Tropomyosin kinase
2612:Tau-protein kinase
223:
36:
4101:
4100:
3810:
3809:
3806:
3805:
3682:
3681:
3621:
3620:
3522:
3521:
3435:Template-directed
3189:
3188:
3156:Phosphomevalonate
2848:
2847:
2844:
2843:
2840:
2839:
2770:
2769:
2766:
2765:
2146:
2145:
2142:
2141:
1627:Protein kinase N1
1582:Protein kinase Cζ
636:(10): 4996–5002.
594:10.1242/jcs.03326
587:(Pt 1): 101–114.
503:(23): 6869–6875.
51:enzyme inhibitors
16:(Redirected from
4153:
4118:
4117:
4109:
3981:Hanes–Woolf plot
3924:Enzyme activator
3919:Enzyme inhibitor
3893:Enzyme catalysis
3837:
3830:
3823:
3814:
3798:Histidine kinase
3721:tyrosine kinases
3711:protein-tyrosine
3703:
3633:
3440:RNA polymerase I
3263:
3254:
3107:Aspartate kinase
3102:Phosphoglycerate
2919:
2875:
2868:
2861:
2852:
2790:
2776:
2423:C-Jun N-terminal
2166:
2152:
1656:Rhodopsin kinase
1647:Rhodopsin kinase
1577:Protein kinase C
1568:Protein kinase C
1553:Protein kinase G
1514:Protein kinase A
1125:Protein kinase B
1057:
1043:
1019:
1012:
1005:
996:
958:
955:
949:
948:
911:
905:
904:
894:
877:(3): 1107–1117.
862:
856:
855:
845:
813:
807:
806:
796:
779:(3): 1305–1318.
760:
754:
753:
735:
711:
705:
704:
686:
662:
656:
655:
645:
621:
615:
614:
596:
572:
566:
565:
537:
531:
530:
512:
488:
482:
481:
445:
439:
438:
419:10.1038/35048096
402:
396:
395:
358:
352:
351:
315:
309:
308:
280:
213:Aurora structure
202:
188:
174:
87:Drug development
21:
4161:
4160:
4156:
4155:
4154:
4152:
4151:
4150:
4126:
4125:
4124:
4112:
4104:
4102:
4097:
4009:Oxidoreductases
3995:
3971:Enzyme kinetics
3959:
3955:List of enzymes
3928:
3897:
3868:Catalytic triad
3846:
3841:
3811:
3802:
3773:
3751:
3726:
3697:
3691:
3687:2.7.10-2.7.13:
3678:
3662:
3629:: miscellaneous
3617:
3591:
3573:
3550:
3533:exoribonuclease
3530:
3518:
3504:Polyadenylation
3421:
3247:
3241:
3229:
3211:
3207:
3201:
3185:
3147:
3134:
3111:
3083:
2913:
2907:
2899:
2893:
2879:
2849:
2836:
2784:
2762:
2686:
2669:
2652:
2635:
2606:
2466:
2366:
2337:P70-S6 Kinase 1
2307:
2198:
2160:
2138:
2104:
2080:
2041:
2007:
1713:
1684:
1660:
1641:
1562:
1538:
1499:
1455:
1438:
1414:
1408:Aurora C kinase
1403:Aurora B kinase
1398:Aurora A kinase
1378:
1359:
1325:
1296:
1229:
1195:
1051:
1037:
1023:
966:
961:
956:
952:
917:Nature Medicine
913:
912:
908:
864:
863:
859:
815:
814:
810:
762:
761:
757:
713:
712:
708:
671:Cancer Research
664:
663:
659:
630:Cancer Research
623:
622:
618:
574:
573:
569:
539:
538:
534:
490:
489:
485:
462:10.1038/nrc1502
456:(12): 927–936.
447:
446:
442:
404:
403:
399:
364:Nature Genetics
360:
359:
355:
317:
316:
312:
282:
281:
277:
273:
251:
227:activation loop
215:
208:
203:
194:
189:
180:
175:
163:Merck & Co.
132:prostate cancer
113:phosphorylating
105:Aurora Borealis
89:
23:
22:
15:
12:
11:
5:
4159:
4157:
4149:
4148:
4143:
4138:
4128:
4127:
4123:
4122:
4099:
4098:
4096:
4095:
4082:
4069:
4056:
4043:
4030:
4017:
4003:
4001:
3997:
3996:
3994:
3993:
3988:
3983:
3978:
3973:
3967:
3965:
3961:
3960:
3958:
3957:
3952:
3947:
3942:
3936:
3934:
3933:Classification
3930:
3929:
3927:
3926:
3921:
3916:
3911:
3905:
3903:
3899:
3898:
3896:
3895:
3890:
3885:
3880:
3875:
3870:
3865:
3860:
3854:
3852:
3848:
3847:
3842:
3840:
3839:
3832:
3825:
3817:
3808:
3807:
3804:
3803:
3801:
3800:
3795:
3790:
3784:
3782:
3775:
3774:
3772:
3771:
3762:
3760:
3753:
3752:
3750:
3749:
3740:
3738:
3728:
3727:
3725:
3724:
3715:
3713:
3700:
3695:
3689:protein kinase
3684:
3683:
3680:
3679:
3677:
3676:
3670:
3668:
3664:
3663:
3661:
3660:
3655:
3650:
3645:
3639:
3637:
3630:
3623:
3622:
3619:
3618:
3616:
3615:
3610:
3599:
3597:
3593:
3592:
3590:
3589:
3583:
3581:
3575:
3574:
3572:
3571:
3566:
3560:
3558:
3552:
3551:
3549:
3548:
3543:
3537:
3535:
3528:Phosphorolytic
3524:
3523:
3520:
3519:
3517:
3516:
3511:
3506:
3501:
3496:
3495:
3494:
3489:
3484:
3474:
3473:
3472:
3462:
3457:
3452:
3447:
3442:
3437:
3431:
3429:
3427:RNA polymerase
3423:
3422:
3420:
3419:
3418:
3417:
3407:
3403:
3402:
3401:
3400:
3395:
3390:
3379:
3378:
3377:
3372:
3367:
3362:
3351:
3345:
3344:
3343:
3336:
3331:
3326:
3321:
3310:
3309:
3308:
3301:
3296:
3291:
3286:
3275:
3271:
3269:
3267:DNA polymerase
3260:
3251:
3245:
3231:
3230:
3228:
3227:
3222:
3216:
3214:
3209:
3205:
3191:
3190:
3187:
3186:
3184:
3183:
3178:
3173:
3168:
3163:
3158:
3152:
3150:
3145:
3136:
3135:
3133:
3132:
3126:
3124:
3113:
3112:
3110:
3109:
3104:
3098:
3096:
3085:
3084:
3082:
3081:
3076:
3071:
3070:
3069:
3064:
3054:
3052:Diacylglycerol
3049:
3044:
3039:
3034:
3029:
3024:
3019:
3014:
3013:
3012:
3002:
2997:
2992:
2991:
2990:
2985:
2980:
2975:
2970:
2963:Phosphofructo-
2960:
2955:
2954:
2953:
2943:
2938:
2932:
2930:
2916:
2911:
2895:
2894:
2880:
2878:
2877:
2870:
2863:
2855:
2846:
2845:
2842:
2841:
2838:
2837:
2835:
2834:
2829:
2824:
2819:
2814:
2809:
2804:
2798:
2796:
2786:
2785:
2779:
2772:
2771:
2768:
2767:
2764:
2763:
2761:
2760:
2755:
2750:
2745:
2740:
2735:
2730:
2725:
2724:
2723:
2718:
2713:
2708:
2697:
2695:
2694:(EC 2.7.11.30)
2688:
2687:
2685:
2684:
2680:
2678:
2677:(EC 2.7.11.29)
2671:
2670:
2668:
2667:
2663:
2661:
2660:(EC 2.7.11.28)
2654:
2653:
2651:
2650:
2646:
2644:
2643:(EC 2.7.11.27)
2637:
2636:
2634:
2633:
2628:
2623:
2617:
2615:
2614:(EC 2.7.11.26)
2608:
2607:
2605:
2604:
2599:
2594:
2593:
2592:
2587:
2582:
2577:
2572:
2567:
2562:
2552:
2551:
2550:
2545:
2540:
2535:
2525:
2524:
2523:
2518:
2513:
2508:
2503:
2498:
2493:
2488:
2477:
2475:
2474:(EC 2.7.11.25)
2468:
2467:
2465:
2464:
2463:
2462:
2457:
2452:
2442:
2441:
2440:
2435:
2430:
2420:
2419:
2418:
2413:
2408:
2403:
2398:
2393:
2388:
2377:
2375:
2374:(EC 2.7.11.24)
2368:
2367:
2365:
2364:
2359:
2354:
2349:
2344:
2339:
2334:
2329:
2324:
2318:
2316:
2315:(EC 2.7.11.23)
2309:
2308:
2306:
2305:
2300:
2295:
2290:
2285:
2280:
2275:
2270:
2265:
2260:
2255:
2250:
2245:
2240:
2235:
2230:
2225:
2220:
2215:
2209:
2207:
2206:(EC 2.7.11.22)
2200:
2199:
2197:
2196:
2191:
2186:
2181:
2175:
2173:
2172:(EC 2.7.11.21)
2162:
2161:
2155:
2148:
2147:
2144:
2143:
2140:
2139:
2137:
2136:
2131:
2126:
2121:
2115:
2113:
2112:(EC 2.7.11.21)
2106:
2105:
2103:
2102:
2097:
2091:
2089:
2088:(EC 2.7.11.20)
2082:
2081:
2079:
2078:
2073:
2068:
2063:
2058:
2052:
2050:
2049:(EC 2.7.11.19)
2043:
2042:
2040:
2039:
2034:
2029:
2024:
2018:
2016:
2015:(EC 2.7.11.18)
2009:
2008:
2006:
2005:
2000:
1995:
1990:
1985:
1980:
1975:
1970:
1965:
1960:
1955:
1950:
1945:
1940:
1935:
1930:
1925:
1920:
1915:
1910:
1905:
1900:
1895:
1890:
1885:
1880:
1875:
1870:
1865:
1860:
1855:
1850:
1845:
1840:
1835:
1830:
1825:
1820:
1815:
1810:
1805:
1800:
1795:
1790:
1785:
1780:
1775:
1770:
1765:
1760:
1755:
1750:
1745:
1740:
1735:
1730:
1724:
1722:
1721:(EC 2.7.11.17)
1715:
1714:
1712:
1711:
1706:
1701:
1695:
1693:
1692:(EC 2.7.11.16)
1686:
1685:
1683:
1682:
1677:
1671:
1669:
1668:(EC 2.7.11.15)
1662:
1661:
1659:
1658:
1652:
1650:
1649:(EC 2.7.11.14)
1643:
1642:
1640:
1639:
1634:
1629:
1624:
1619:
1614:
1609:
1604:
1599:
1594:
1589:
1584:
1579:
1573:
1571:
1570:(EC 2.7.11.13)
1564:
1563:
1561:
1560:
1555:
1549:
1547:
1546:(EC 2.7.11.12)
1540:
1539:
1537:
1536:
1531:
1526:
1521:
1516:
1510:
1508:
1507:(EC 2.7.11.11)
1501:
1500:
1498:
1497:
1492:
1487:
1482:
1477:
1472:
1466:
1464:
1463:(EC 2.7.11.10)
1457:
1456:
1454:
1453:
1449:
1447:
1440:
1439:
1437:
1436:
1431:
1425:
1423:
1416:
1415:
1413:
1412:
1411:
1410:
1405:
1400:
1389:
1387:
1380:
1379:
1377:
1376:
1370:
1368:
1361:
1360:
1358:
1357:
1352:
1347:
1342:
1336:
1334:
1327:
1326:
1324:
1323:
1318:
1313:
1307:
1305:
1298:
1297:
1295:
1294:
1293:
1292:
1287:
1282:
1274:
1273:
1272:
1267:
1259:
1258:
1257:
1252:
1240:
1238:
1231:
1230:
1228:
1227:
1222:
1217:
1212:
1206:
1204:
1197:
1196:
1194:
1193:
1192:
1191:
1181:
1180:
1179:
1174:
1169:
1164:
1154:
1149:
1144:
1143:
1142:
1137:
1132:
1122:
1117:
1112:
1107:
1102:
1097:
1092:
1087:
1082:
1077:
1072:
1066:
1064:
1053:
1052:
1046:
1039:
1038:
1024:
1022:
1021:
1014:
1007:
999:
993:
992:
982:
977:
972:
965:
964:External links
962:
960:
959:
950:
929:10.1038/nm1003
923:(3): 262–267.
906:
857:
828:(2): 281–294.
808:
755:
706:
677:(2): 463–467.
657:
616:
567:
542:Genes to Cells
532:
483:
440:
397:
376:10.1038/ng1220
370:(4): 403–412.
353:
326:(4): 451–464.
310:
291:(6): 672–683.
274:
272:
269:
268:
267:
262:
257:
250:
247:
239:hydrogen bonds
231:protein kinase
214:
211:
210:
209:
204:
197:
195:
190:
183:
181:
176:
169:
155:clinical trial
88:
85:
24:
14:
13:
10:
9:
6:
4:
3:
2:
4158:
4147:
4144:
4142:
4139:
4137:
4134:
4133:
4131:
4121:
4116:
4111:
4107:
4093:
4089:
4088:
4083:
4080:
4076:
4075:
4070:
4067:
4063:
4062:
4057:
4054:
4050:
4049:
4044:
4041:
4037:
4036:
4031:
4028:
4024:
4023:
4018:
4015:
4011:
4010:
4005:
4004:
4002:
3998:
3992:
3989:
3987:
3984:
3982:
3979:
3977:
3974:
3972:
3969:
3968:
3966:
3962:
3956:
3953:
3951:
3950:Enzyme family
3948:
3946:
3943:
3941:
3938:
3937:
3935:
3931:
3925:
3922:
3920:
3917:
3915:
3914:Cooperativity
3912:
3910:
3907:
3906:
3904:
3900:
3894:
3891:
3889:
3886:
3884:
3881:
3879:
3876:
3874:
3873:Oxyanion hole
3871:
3869:
3866:
3864:
3861:
3859:
3856:
3855:
3853:
3849:
3845:
3838:
3833:
3831:
3826:
3824:
3819:
3818:
3815:
3799:
3796:
3794:
3791:
3789:
3786:
3785:
3783:
3780:
3776:
3770:
3769:
3764:
3763:
3761:
3758:
3754:
3748:
3747:
3742:
3741:
3739:
3737:
3733:
3729:
3723:
3722:
3717:
3716:
3714:
3712:
3708:
3704:
3701:
3698:
3690:
3685:
3675:
3672:
3671:
3669:
3665:
3659:
3656:
3654:
3651:
3649:
3646:
3644:
3641:
3640:
3638:
3634:
3631:
3628:
3624:
3614:
3611:
3608:
3604:
3601:
3600:
3598:
3594:
3588:
3585:
3584:
3582:
3580:
3576:
3570:
3567:
3565:
3562:
3561:
3559:
3557:
3553:
3547:
3544:
3542:
3539:
3538:
3536:
3534:
3529:
3525:
3515:
3512:
3510:
3507:
3505:
3502:
3500:
3497:
3493:
3490:
3488:
3485:
3483:
3480:
3479:
3478:
3475:
3471:
3468:
3467:
3466:
3463:
3461:
3458:
3456:
3453:
3451:
3448:
3446:
3443:
3441:
3438:
3436:
3433:
3432:
3430:
3428:
3424:
3416:
3413:
3412:
3411:
3408:
3405:
3404:
3399:
3396:
3394:
3391:
3389:
3386:
3385:
3383:
3380:
3376:
3373:
3371:
3368:
3366:
3363:
3361:
3358:
3357:
3355:
3352:
3349:
3346:
3342:
3341:
3337:
3335:
3332:
3330:
3327:
3325:
3322:
3320:
3317:
3316:
3314:
3311:
3307:
3306:
3302:
3300:
3297:
3295:
3292:
3290:
3287:
3285:
3282:
3281:
3279:
3276:
3273:
3272:
3270:
3268:
3264:
3261:
3259:
3255:
3252:
3249:
3240:
3236:
3232:
3226:
3223:
3221:
3218:
3217:
3215:
3212:
3200:
3196:
3192:
3182:
3179:
3177:
3174:
3172:
3169:
3167:
3164:
3162:
3159:
3157:
3154:
3153:
3151:
3148:
3141:
3137:
3131:
3128:
3127:
3125:
3122:
3118:
3114:
3108:
3105:
3103:
3100:
3099:
3097:
3094:
3090:
3086:
3080:
3077:
3075:
3072:
3068:
3067:Class II PI 3
3065:
3063:
3060:
3059:
3058:
3055:
3053:
3050:
3048:
3045:
3043:
3042:Deoxycytidine
3040:
3038:
3035:
3033:
3030:
3028:
3025:
3023:
3020:
3018:
3015:
3011:
3010:ADP-thymidine
3008:
3007:
3006:
3003:
3001:
2998:
2996:
2993:
2989:
2986:
2984:
2981:
2979:
2976:
2974:
2971:
2969:
2966:
2965:
2964:
2961:
2959:
2956:
2952:
2949:
2948:
2947:
2944:
2942:
2939:
2937:
2934:
2933:
2931:
2928:
2924:
2920:
2917:
2914:
2906:
2902:
2896:
2891:
2887:
2883:
2876:
2871:
2869:
2864:
2862:
2857:
2856:
2853:
2833:
2830:
2828:
2825:
2823:
2820:
2818:
2815:
2813:
2810:
2808:
2805:
2803:
2800:
2799:
2797:
2795:
2791:
2787:
2782:
2777:
2773:
2759:
2756:
2754:
2751:
2749:
2746:
2744:
2741:
2739:
2736:
2734:
2731:
2729:
2726:
2722:
2719:
2717:
2714:
2712:
2709:
2707:
2704:
2703:
2702:
2699:
2698:
2696:
2693:
2689:
2682:
2681:
2679:
2676:
2672:
2665:
2664:
2662:
2659:
2655:
2648:
2647:
2645:
2642:
2638:
2632:
2629:
2627:
2624:
2622:
2619:
2618:
2616:
2613:
2609:
2603:
2600:
2598:
2595:
2591:
2588:
2586:
2583:
2581:
2578:
2576:
2573:
2571:
2568:
2566:
2563:
2561:
2558:
2557:
2556:
2553:
2549:
2546:
2544:
2541:
2539:
2536:
2534:
2531:
2530:
2529:
2526:
2522:
2519:
2517:
2514:
2512:
2509:
2507:
2504:
2502:
2499:
2497:
2494:
2492:
2489:
2487:
2484:
2483:
2482:
2479:
2478:
2476:
2473:
2469:
2461:
2458:
2456:
2453:
2451:
2448:
2447:
2446:
2443:
2439:
2436:
2434:
2431:
2429:
2426:
2425:
2424:
2421:
2417:
2414:
2412:
2409:
2407:
2404:
2402:
2399:
2397:
2394:
2392:
2389:
2387:
2384:
2383:
2382:
2379:
2378:
2376:
2373:
2369:
2363:
2360:
2358:
2355:
2353:
2350:
2348:
2345:
2343:
2340:
2338:
2335:
2333:
2330:
2328:
2325:
2323:
2320:
2319:
2317:
2314:
2310:
2304:
2301:
2299:
2296:
2294:
2291:
2289:
2286:
2284:
2281:
2279:
2276:
2274:
2271:
2269:
2266:
2264:
2261:
2259:
2256:
2254:
2251:
2249:
2246:
2244:
2241:
2239:
2236:
2234:
2231:
2229:
2226:
2224:
2221:
2219:
2216:
2214:
2211:
2210:
2208:
2205:
2201:
2195:
2192:
2190:
2187:
2185:
2182:
2180:
2177:
2176:
2174:
2171:
2167:
2163:
2158:
2153:
2149:
2135:
2132:
2130:
2127:
2125:
2122:
2120:
2117:
2116:
2114:
2111:
2107:
2101:
2098:
2096:
2093:
2092:
2090:
2087:
2083:
2077:
2074:
2072:
2069:
2067:
2064:
2062:
2059:
2057:
2054:
2053:
2051:
2048:
2044:
2038:
2035:
2033:
2030:
2028:
2025:
2023:
2020:
2019:
2017:
2014:
2010:
2004:
2001:
1999:
1996:
1994:
1991:
1989:
1986:
1984:
1981:
1979:
1976:
1974:
1971:
1969:
1966:
1964:
1961:
1959:
1956:
1954:
1951:
1949:
1946:
1944:
1941:
1939:
1936:
1934:
1931:
1929:
1926:
1924:
1921:
1919:
1916:
1914:
1911:
1909:
1906:
1904:
1901:
1899:
1896:
1894:
1891:
1889:
1886:
1884:
1881:
1879:
1876:
1874:
1871:
1869:
1866:
1864:
1861:
1859:
1856:
1854:
1851:
1849:
1846:
1844:
1841:
1839:
1836:
1834:
1831:
1829:
1826:
1824:
1821:
1819:
1816:
1814:
1811:
1809:
1806:
1804:
1801:
1799:
1796:
1794:
1791:
1789:
1786:
1784:
1781:
1779:
1776:
1774:
1771:
1769:
1766:
1764:
1761:
1759:
1756:
1754:
1751:
1749:
1746:
1744:
1741:
1739:
1736:
1734:
1731:
1729:
1726:
1725:
1723:
1720:
1716:
1710:
1707:
1705:
1702:
1700:
1697:
1696:
1694:
1691:
1687:
1681:
1678:
1676:
1673:
1672:
1670:
1667:
1663:
1657:
1654:
1653:
1651:
1648:
1644:
1638:
1635:
1633:
1630:
1628:
1625:
1623:
1620:
1618:
1615:
1613:
1610:
1608:
1605:
1603:
1600:
1598:
1595:
1593:
1590:
1588:
1585:
1583:
1580:
1578:
1575:
1574:
1572:
1569:
1565:
1559:
1556:
1554:
1551:
1550:
1548:
1545:
1541:
1535:
1532:
1530:
1527:
1525:
1522:
1520:
1517:
1515:
1512:
1511:
1509:
1506:
1502:
1496:
1493:
1491:
1488:
1486:
1483:
1481:
1478:
1476:
1473:
1471:
1468:
1467:
1465:
1462:
1458:
1451:
1450:
1448:
1446:(EC 2.7.11.9)
1445:
1441:
1435:
1432:
1430:
1427:
1426:
1424:
1422:(EC 2.7.11.8)
1421:
1417:
1409:
1406:
1404:
1401:
1399:
1396:
1395:
1394:
1393:Aurora kinase
1391:
1390:
1388:
1386:(EC 2.7.11.7)
1385:
1381:
1375:
1372:
1371:
1369:
1367:(EC 2.7.11.6)
1366:
1362:
1356:
1353:
1351:
1348:
1346:
1343:
1341:
1338:
1337:
1335:
1333:(EC 2.7.11.5)
1332:
1328:
1322:
1319:
1317:
1314:
1312:
1309:
1308:
1306:
1304:(EC 2.7.11.4)
1303:
1299:
1291:
1288:
1286:
1283:
1281:
1278:
1277:
1275:
1271:
1268:
1266:
1263:
1262:
1260:
1256:
1253:
1251:
1248:
1247:
1245:
1242:
1241:
1239:
1237:(EC 2.7.11.3)
1236:
1232:
1226:
1223:
1221:
1218:
1216:
1213:
1211:
1208:
1207:
1205:
1203:(EC 2.7.11.2)
1202:
1198:
1190:
1187:
1186:
1185:
1182:
1178:
1175:
1173:
1170:
1168:
1165:
1163:
1160:
1159:
1158:
1157:EIF-2 kinases
1155:
1153:
1150:
1148:
1145:
1141:
1138:
1136:
1133:
1131:
1128:
1127:
1126:
1123:
1121:
1118:
1116:
1113:
1111:
1108:
1106:
1103:
1101:
1098:
1096:
1093:
1091:
1088:
1086:
1083:
1081:
1078:
1076:
1073:
1071:
1068:
1067:
1065:
1063:(EC 2.7.11.1)
1062:
1058:
1054:
1049:
1044:
1040:
1035:
1031:
1027:
1020:
1015:
1013:
1008:
1006:
1001:
1000:
997:
990:
986:
983:
981:
978:
976:
973:
971:
968:
967:
963:
954:
951:
946:
942:
938:
934:
930:
926:
922:
918:
910:
907:
902:
898:
893:
888:
884:
880:
876:
872:
868:
861:
858:
853:
849:
844:
839:
835:
831:
827:
823:
819:
812:
809:
804:
800:
795:
790:
786:
782:
778:
774:
770:
768:
759:
756:
751:
747:
743:
739:
734:
729:
725:
721:
717:
710:
707:
702:
698:
694:
690:
685:
680:
676:
672:
668:
661:
658:
653:
649:
644:
639:
635:
631:
627:
620:
617:
612:
608:
604:
600:
595:
590:
586:
582:
578:
571:
568:
563:
559:
555:
551:
547:
543:
536:
533:
528:
524:
520:
516:
511:
506:
502:
498:
494:
487:
484:
479:
475:
471:
467:
463:
459:
455:
451:
444:
441:
436:
432:
428:
424:
420:
416:
412:
408:
401:
398:
393:
389:
385:
381:
377:
373:
369:
365:
357:
354:
349:
345:
341:
337:
333:
329:
325:
321:
314:
311:
306:
302:
298:
294:
290:
286:
279:
276:
270:
266:
263:
261:
258:
256:
253:
252:
248:
246:
244:
240:
236:
232:
228:
219:
212:
207:
201:
196:
193:
187:
182:
179:
173:
168:
166:
164:
160:
156:
152:
148:
144:
139:
137:
136:breast cancer
133:
129:
125:
121:
117:
114:
110:
106:
102:
98:
94:
86:
84:
82:
79:
75:
71:
67:
63:
59:
54:
52:
48:
47:Aurora kinase
44:
40:
34:
29:
19:
4087:Translocases
4084:
4071:
4058:
4045:
4032:
4022:Transferases
4019:
4006:
3863:Binding site
3765:
3743:
3718:
3339:
3304:
3062:Class I PI 3
3027:Pantothenate
2898:2.7.1-2.7.4:
2882:Transferases
2332:P70S6 kinase
953:
920:
916:
909:
874:
870:
860:
825:
821:
811:
776:
772:
766:
758:
723:
719:
709:
674:
670:
660:
633:
629:
619:
584:
580:
570:
548:(1): 11–17.
545:
541:
535:
500:
496:
486:
453:
449:
443:
413:(1): 21–32.
410:
406:
400:
367:
363:
356:
323:
319:
313:
288:
284:
278:
224:
140:
128:colon cancer
90:
55:
38:
37:
3858:Active site
3613:Transposase
3603:Recombinase
3248:-nucleoside
3074:Sphingosine
2783:(EC 2.7.12)
2170:Polo kinase
2110:Polo kinase
726:(1): 1–10.
74:oncogenesis
62:cytokinesis
33:cytokinesis
4136:Cell cycle
4130:Categories
4061:Isomerases
4035:Hydrolases
3902:Regulation
3415:Telomerase
3258:Polymerase
3032:Mevalonate
2995:Riboflavin
2886:phosphorus
1461:IÎşB kinase
1036:2.7.11-12)
991:-animation
271:References
192:Hesperadin
147:hesperadin
109:nucleosome
78:penetrance
58:cell cycle
3940:EC number
3607:Integrase
3531:3' to 5'
3176:Guanylate
3171:Uridylate
3161:Adenylate
3005:Thymidine
3000:Shikimate
1587:PKC alpha
769:Extracts"
435:205011994
235:adenosine
120:oncogenic
70:mammalian
3964:Kinetics
3888:Cofactor
3851:Activity
3541:RNase PH
3149:acceptor
3130:Creatine
3123:acceptor
3095:acceptor
3037:Pyruvate
3022:Glycerol
2983:Platelet
2958:Galacto-
2929:acceptor
1943:KIAA0999
1838:MAPKAPK5
1833:MAPKAPK3
1828:MAPKAPK2
945:12918452
937:14981513
901:17215513
852:12707311
803:15616188
750:22233833
742:17259342
701:11727346
693:14744757
652:16707419
611:30767479
603:17164288
562:11856369
527:34256297
519:17145803
478:28256419
470:15573114
427:11413462
392:29442841
384:12881723
348:25350728
340:12884918
305:14644191
249:See also
178:ZM447439
143:ZM447439
138:tumors.
124:leukemia
4141:Mitosis
4120:Biology
4074:Ligases
3844:Enzymes
3492:PrimPol
3477:Primase
2951:Hepatic
2946:Fructo-
2602:MAP3K14
2580:MAP3K11
2575:MAP3K10
2565:MAP3K13
2560:MAP3K12
2362:RPS6KC1
2357:RPS6KA1
2352:RPS6KA3
2347:RPS6KA2
2342:RPS6KB2
2327:RPS6KA4
2322:RPS6KA5
1973:Kalirin
1938:SNF1LK2
1177:EIF2AK4
1172:EIF2AK3
1026:Kinases
987:- PMAP
892:1805108
843:2172906
116:histone
101:mitotic
97:mitosis
93:enzymes
45:. The
4106:Portal
4048:Lyases
3779:2.7.13
3757:2.7.12
3732:2.7.11
3707:2.7.10
3546:PNPase
3514:PNPase
3470:POLRMT
3465:ssRNAP
2978:Muscle
2941:Gluco-
2905:kinase
2832:MAP2K7
2827:MAP2K6
2822:MAP2K5
2817:MAP2K4
2812:MAP2K3
2807:MAP2K2
2802:MAP2K1
2753:ACVRL1
2748:ACVR2B
2743:ACVR2A
2738:ACVR1C
2733:ACVR1B
2716:BMPR1B
2711:BMPR1A
2585:MAP3K7
2570:MAP3K9
2521:MAP3K8
2516:MAP3K7
2511:MAP3K6
2506:MAP3K5
2501:MAP3K4
2496:MAP3K3
2491:MAP3K2
2486:MAP3K1
2460:MAPK14
2455:MAPK13
2450:MAPK11
2438:MAPK10
2416:MAPK15
2411:MAPK12
2303:CDC2L1
2278:CDC2L5
1953:SNF1LK
1778:CAMK2G
1773:CAMK2D
1768:CAMK2B
1763:CAMK2A
1753:CAMK1G
1748:CAMK1D
1743:CAMK1B
1738:CAMK1A
1592:PRKCB1
1529:PRKACA
1524:PRKACB
1519:PRKACG
1495:IKBKAP
1321:BCKDHB
1316:BCKDHA
1290:PRKAG3
1285:PRKAG2
1280:PRKAG1
1270:PRKAB2
1265:PRKAB1
1255:PRKAA2
1250:PRKAA1
1095:STK38L
943:
935:
899:
889:
850:
840:
801:
794:551494
791:
748:
740:
699:
691:
650:
609:
601:
560:
525:
517:
476:
468:
433:
425:
390:
382:
346:
338:
303:
255:Kinome
243:ribose
206:VX-680
151:VX-680
66:cancer
43:cancer
4000:Types
3627:2.7.8
3596:Other
3235:2.7.7
3195:2.7.6
3140:2.7.4
3117:2.7.3
3089:2.7.2
2973:Liver
2936:Hexo-
2923:2.7.1
2794:MAP2K
2728:ACVR1
2721:BMPR2
2706:BMPR1
2631:GSK-3
2472:MAP3K
2433:MAPK9
2428:MAPK8
2406:MAPK7
2401:MAPK6
2396:MAPK4
2391:MAPK3
2386:MAPK1
2298:PFTK1
2293:PCTK3
2288:PCTK2
2283:PCTK1
2273:CDK12
2268:CDK10
2243:CDKL5
2223:CDKL2
2100:STK19
2095:EEF2K
2076:PHKG2
2071:PHKG1
2061:PHKA2
2056:PHKA1
2037:MYLK4
2032:MYLK3
2027:MYLK2
2003:DCLK1
1998:Titin
1988:TRIB3
1983:TRIB2
1978:TRIB1
1968:TSSK2
1948:STK40
1933:PSKH1
1928:PRKD3
1923:PRKD2
1903:PHKG2
1898:PHKG1
1888:OBSCN
1883:NUAK2
1878:NUAK1
1873:MKNK2
1868:MKNK1
1858:MARK4
1853:MARK3
1848:MARK2
1843:MARK1
1823:STK11
1818:DAPK3
1813:DAPK2
1808:DAPK1
1803:CHEK2
1798:CHEK1
1783:CAMK4
1758:CAMK2
1733:CAMK1
1728:BRSK2
1622:PRKCQ
1617:PRKCI
1612:PRKCG
1607:PRKCH
1602:PRKCE
1597:PRKCD
1558:PRKG1
1490:IKBKG
1485:IKBKE
1434:STK10
1429:FASTK
1355:IDH3G
1350:IDH3B
1345:IDH3A
1311:BCKDK
1105:ROCK1
1090:STK38
1085:MAST2
1080:MAST1
1075:LATS2
1070:LATS1
941:S2CID
746:S2CID
697:S2CID
607:S2CID
523:S2CID
474:S2CID
431:S2CID
388:S2CID
344:S2CID
81:tumor
4092:list
4085:EC7
4079:list
4072:EC6
4066:list
4059:EC5
4053:list
4046:EC4
4040:list
4033:EC3
4027:list
4020:EC2
4014:list
4007:EC1
3766:see
3744:see
3719:see
3093:COOH
2892:2.7)
2621:TPK1
2597:CDC7
2555:MLKs
2548:KSR2
2543:KSR1
2538:BRAF
2533:ARAF
2528:RAFs
2263:CDK9
2258:CDK8
2253:CDK7
2248:CDK6
2238:CDK5
2233:CDK4
2228:CDK3
2218:CDK2
2213:CDK1
2194:PLK4
2189:PLK3
2184:PLK2
2179:PLK1
2134:PLK4
2129:PLK3
2124:PLK2
2119:PLK1
2066:PHKB
2022:MYLK
1993:TRIO
1963:SPEG
1958:SNRK
1918:PKD1
1913:PIM2
1908:PIM1
1893:PASK
1863:MELK
1793:CASK
1788:MLCK
1709:GRK6
1704:GRK5
1699:GRK4
1637:PKN3
1632:PKN2
1534:PRKY
1480:TBK1
1475:IKK2
1470:CHUK
1374:STK4
1340:IDH2
1225:PDK4
1220:PDK3
1215:PDK2
1210:PDK1
1189:WEE1
1184:Wee1
1152:mTOR
1140:AKT3
1135:AKT2
1130:AKT1
1120:SGK3
1115:SGK2
933:PMID
897:PMID
848:PMID
799:PMID
738:PMID
689:PMID
648:PMID
599:PMID
558:PMID
515:PMID
466:PMID
423:PMID
380:PMID
336:PMID
301:PMID
149:and
134:and
3509:PAP
3450:III
3384:/Y
3375:TDT
3356:/X
3348:III
3340:Pfu
3315:/B
3305:Taq
3280:/A
3047:PFP
3017:NAD
2626:TTK
2590:ZAK
1167:HRI
1162:PKR
1110:SGK
1100:CIT
925:doi
887:PMC
879:doi
838:PMC
830:doi
826:161
789:PMC
781:doi
767:Egg
728:doi
679:doi
638:doi
589:doi
585:120
550:doi
505:doi
458:doi
415:doi
372:doi
328:doi
293:doi
111:by
4132::
3734::
3709::
3694:PO
3455:IV
3445:II
3354:IV
3350:/C
3313:II
3299:T7
3244:PO
3237::
3197::
3144:PO
3142::
3119::
3091::
2927:OH
2925::
2910:PO
2890:EC
2884::
1276:Îł
1261:β
1246:α
1034:EC
1028::
939:.
931:.
921:10
919:.
895:.
885:.
875:18
873:.
869:.
846:.
836:.
824:.
820:.
797:.
787:.
777:16
775:.
771:.
744:.
736:.
722:.
718:.
695:.
687:.
675:64
673:.
669:.
646:.
634:66
632:.
628:.
605:.
597:.
583:.
579:.
556:.
544:.
521:.
513:.
501:12
499:.
495:.
472:.
464:.
452:.
429:.
421:.
409:.
386:.
378:.
368:34
366:.
342:.
334:.
324:22
322:.
299:.
289:15
287:.
145:,
130:,
126:,
53:.
4108::
4094:)
4090:(
4081:)
4077:(
4068:)
4064:(
4055:)
4051:(
4042:)
4038:(
4029:)
4025:(
4016:)
4012:(
3836:e
3829:t
3822:v
3696:4
3692:(
3609:)
3605:(
3487:2
3482:1
3460:V
3398:Îş
3393:Îą
3388:η
3382:V
3370:ÎĽ
3365:λ
3360:β
3334:ζ
3329:ε
3324:δ
3319:α
3294:ν
3289:θ
3284:Îł
3278:I
3250:)
3246:4
3242:(
3213:)
3210:7
3208:O
3206:2
3204:P
3202:(
3146:4
3121:N
2988:2
2968:1
2915:)
2912:4
2908:(
2903:/
2874:e
2867:t
2860:v
2683:-
2666:-
2649:-
1452:-
1032:(
1018:e
1011:t
1004:v
947:.
927::
903:.
881::
854:.
832::
805:.
783::
752:.
730::
724:5
703:.
681::
654:.
640::
613:.
591::
564:.
552::
546:7
529:.
507::
480:.
460::
454:4
437:.
417::
411:2
394:.
374::
350:.
330::
307:.
295::
20:)
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