342:
319:
216:
241:
5218:
5188:
593:
348:
247:
1973:
600:
5203:
49:
1985:
1695:, a 2008 study compared people with various genetic CRP variants. Those with a high CRP due to genetic variation had no increased risk of cardiovascular disease compared to those with a normal or low CRP. A study published in 2011 shows that CRP is associated with lipid responses to low-fat and high-polyunsaturated fat diets.
1493:. It can double every 8 hours and reaches its peak at 36 to 50 hours following injury or inflammation. CRP between 100 and 500 mg/L is considered highly predictive of inflammation due to bacterial infection. Once inflammation subsides, CRP level falls quickly because of its relatively short half-life.
1715:
prognostic indicator. Nevertheless, a level above 2.4 mg/L has been associated with a doubled risk of a coronary event compared to levels below 1 mg/L; however, the study group in this case consisted of patients who had been diagnosed with unstable angina pectoris; whether elevated CRP has
1851:
had higher average CRP concentrations than people without colon cancer. It can be noted that the average CRP levels in both groups were well within the range of CRP levels usually found in healthy people. However, these findings may suggest that low inflammation level can be associated with a lower
1430:
patients. Current immunoassay methods for CRP have similar precision to hsCRP performed by nephelometry and could probably replace hsCRP for cardiovascular risk assessment, however, in the United States this would represent off-label use, making it a laboratory-developed test under FDA regulations.
1676:
that found that elevated CRP levels without hyperlipidemia benefited. Statins were selected because they have been proven to reduce levels of CRP. Studies comparing effect of various statins in hs-CRP revealed similar effects of different statins. A subsequent trial however failed to find that CRP
1642:
consumption had blood levels of CRP that were 73% higher than those in the lowest quartile. Although one group of researchers indicated that CRP may be only a moderate risk factor for cardiovascular disease, this study (known as the
Reykjavik Study) was found to have some problems for this type of
1468:
When there is a stimulus, the CRP level can increase 10,000-fold from less than 50 ÎĽg/L to more than 500 mg/L. Its concentration can increase to 5 mg/L by 6 hours and peak at 48 hours. The plasma half-life of CRP is 19 hours, and is constant in all medical conditions. Therefore, the
1311:
cells and bacteria. With this mechanism, CRP also binds to ischemic/hypoxic cells, which could regenerate with more time. However, the binding of CRP causes them to be disposed of prematurely. CRP is a prehistoric antibody and binds to the Fc-gamma receptor IIa, to which antibodies also bind. In
1839:
The role of inflammation in cancer is not well understood. Some organs of the body show greater risk of cancer when they are chronically inflamed. While there is an association between increased levels of C-reactive protein and risk of developing cancer, there is no association between genetic
3443:
Liu S, Ren J, Xia Q, Wu X, Han G, Ren H, et al. (December 2013). "Preliminary case-control study to evaluate diagnostic values of C-reactive protein and erythrocyte sedimentation rate in differentiating active Crohn's disease from intestinal lymphoma, intestinal tuberculosis and Behcet's
2993:
Han E, Fritzer-Szekeres M, Szekeres T, Gehrig T, Gyöngyösi M, Bergler-Klein J. Comparison of High-Sensitivity C-Reactive
Protein vs C-reactive Protein for Cardiovascular Risk Prediction in Chronic Cardiac Disease. J Appl Lab Med. 2022 Oct 29;7(6):1259-1271. doi: 10.1093/jalm/jfac069. PMID:
1892:
classification criteria for RA with abnormal levels accounting for a single point within the criteria. Higher levels of CRP are associated with more severe disease and a higher likelihood of radiographic progression. Rheumatoid arthritis associated antibodies together with 14-3-3η
75:
1933:
were only marginally associated with serum CRP levels and without any association to the DAS28 score. Thus, that DAS28, which is the core parameter for inflammatory activity in RA, can be used for clinical decision-making without adjustment for CRP gene variants.
3408:
Sisto UG, Di Bella S, Porta E, Franzoi G, Cominotto F, Guzzardi E, et al. (June 2024). "Predicting sepsis at emergency department triage: Implementing clinical and laboratory markers within the first nursing assessment to enhance diagnostic accuracy".
1897:
have been reported to complement CRP in predicting clinical and radiographic outcomes in patients with recent onset inflammatory polyarthritis. Elevated levels of CRP appear to be associated with common comorbidities including cardiovascular disease,
1716:
any predictive value of acute coronary events in the general population of all age ranges remains unclear. Currently, C-reactive protein is not recommended as a cardiovascular disease screening test for average-risk adults without symptoms.
4640:"Serum levels of 14-3-3η protein supplement C-reactive protein and rheumatoid arthritis-associated antibodies to predict clinical and radiographic outcomes in a prospective cohort of patients with recent-onset inflammatory polyarthritis"
1868:(OSA). CRP and interleukin-6 (IL-6) levels were significantly higher in patients with OSA compared to obese control subjects. Patients with OSA have higher plasma CRP concentrations that increased corresponding to the severity of their
2907:"Markers of inflammation and cardiovascular disease: application to clinical and public health practice: A statement for healthcare professionals from the Centers for Disease Control and Prevention and the American Heart Association"
1643:
analysis related to the characteristics of the population studied, and there was an extremely long follow-up time, which may have attenuated the association between CRP and future outcomes. Others have shown that CRP can exacerbate
1439:
In healthy adults, the normal concentrations of CRP varies between 0.8 mg/L and 3.0 mg/L. However, some healthy adults show elevated CRP at 10 mg/L. CRP concentrations also increase with age, possibly due to
1688:, CRP levels were found to be reduced after exercise interventions. Among those studies, higher CRP concentrations or poorer lipid profiles before beginning exercise were associated with greater reductions in CRP.
1606:
and the stage of disease presentation. In patients presenting to the emergency department with suspected sepsis, a CRP/albumin ratio of less than 32 has a negative predictive value of 89% for ruling out sepsis.
1425:
risk when in excess of 3 mg/L, whereas below 1 mg/L would be low risk. Traditional CRP measurement is faster and less costly than hs-CRP, and can be adequate for some applications, such as monitoring
1420:
Traditional CRP measurement only detected CRP in the range of 10 to 1,000 mg/L, whereas high sensitivity CRP (hs-CRP) detects CRP in the range of 0.5 to 10 mg/L. hs-CRP can detect
2872:
1711:
within the wall. CRP is a general marker for inflammation and infection, so it can be used as a very rough proxy for heart disease risk. Since many things can cause elevated CRP, this is not a very
3351:"Target Product Profile for a Diagnostic Assay to Differentiate between Bacterial and Non-Bacterial Infections and Reduce Antimicrobial Overuse in Resource-Limited Settings: An Expert Consensus"
1279:
is completed. The complete protein, composed of five monomers, has a total mass of approximately 120,000 Da. In serum, it assembles into stable pentameric structure with a discoid shape.
3651:
4003:
Swardfager W, Herrmann N, Cornish S, Mazereeuw G, Marzolini S, Sham L, et al. (April 2012). "Exercise intervention and inflammatory markers in coronary artery disease: a meta-analysis".
1267:
family (also known as short pentraxins). The polypeptide encoded by this gene has 224 amino acids. The full-length polypeptide is not present in the body in significant quantities due to
5217:
4628:
Kay J, Upchurch KS. ACR/EULAR 2010 rheumatoid arthritis classification criteria. Rheumatology (Oxford). 2012 Dec;51 Suppl 6:vi5-9. doi: 10.1093/rheumatology/kes279. PMID 23221588.
4697:
6088:
1889:
1925:
in the CRP gene may affect clinical decision-making based on CRP in rheumatoid arthritis, e.g. DAS28 (Disease
Activity Score 28 joints). A recent study showed that CRP
5258:
355:
254:
5307:
6122:
3003:
Wolska A, Remaley AT. CRP and High-Sensitivity CRP: "What's in a Name?". J Appl Lab Med. 2022 Oct 29;7(6):1255-1258. doi: 10.1093/jalm/jfac076. PMID: 36136105.
1469:
only factor that affects the blood CRP concentration is its production rate, which increases with inflammation, infection, trauma, necrosis, malignancy, and
1530:
inhibits CRP production from liver cells which may explain the relatively low levels of CRP found during viral infections compared to bacterial infections
6295:
5620:
1724:
177:
2947:
848:
3300:"What's new in Emergencies Trauma and Shock? C-reactive protein as a potential clinical biomarker for influenza infection: More questions than answers"
829:
5292:
1481:. In acute inflammation, CRP can increase as much as 50 to 100 mg/L within 4 to 6 hours in mild to moderate inflammation or an insult such as
1229:
and
Francis in 1930, it was initially thought that CRP might be a pathogenic secretion since it was elevated in a variety of illnesses, including
2229:
Mantovani A, Garlanda C, Doni A, Bottazzi B (January 2008). "Pentraxins in innate immunity: from C-reactive protein to the long pentraxin PTX3".
5187:
1233:. The later discovery of hepatic synthesis (made in the liver) demonstrated that it is a native protein. Initially, CRP was measured using the
3864:"Effects of atorvastatin and rosuvastatin on high-sensitivity C-reactive protein and lipid profile in obese type 2 diabetes mellitus patients"
5167:
2380:
2355:
2330:
2068:
1312:
addition, CRP activates the classical complement pathway via C1q binding. CRP thus forms immune complexes in the same way as IgG antibodies.
3956:"C-reactive protein concentration and the vascular benefits of statin therapy: an analysis of 20,536 patients in the Heart Protection Study"
2050:
6265:
5251:
3195:"C-Reactive Protein Levels in Systemic Lupus Erythematosus Are Modulated by the Interferon Gene Signature and CRP Gene Polymorphism rs1205"
1853:
4762:"CRP genotype and haplotype associations with serum C-reactive protein level and DAS28 in untreated early rheumatoid arthritis patients"
4362:"Genome sequencing elucidates Sardinian genetic architecture and augments association analyses for lipid and blood inflammatory markers"
1873:
1792:. CRP level is an independent risk factor for atherosclerotic disease. Patients with high CRP concentrations are more likely to develop
1244:
CRP was so named because it was first identified as a substance in the serum of patients with acute inflammation that reacted with the
1072:
341:
6115:
4235:
1460:, and polymorphic GT repeat of the CRP gene do affect the usual CRP concentrations when a person does not have any medical illnesses.
1079:
5106:
4954:"Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study"
318:
3954:
Jonathan E, Derrick B, Emma L, Sarah P, John D, Jane A, et al. (Heart
Protection Study Collaborative Group) (February 2011).
5087:
3154:"Interferon-alpha mediates suppression of C-reactive protein: explanation for muted C-reactive protein response in lupus flares?"
2490:
5613:
5244:
2037:
2016:
2373:
Kelley's
Textbook of Rheumatology: 2-Volume Set, Expert Consult: Online and Print (Textbook of Rheumatology (Kelley's)(2 Vol))
6290:
6067:
5444:
2194:
Lau DC, Dhillon B, Yan H, Szmitko PE, Verma S (May 2005). "Adipokines: molecular links between obesity and atheroslcerosis".
1922:
1611:
2033:
1953:(more common) influenza, with a review reporting that severe H1N1 influenza had elevated CRP. In 2020, people infected with
2644:"Being Eaten Alive: How Energy-Deprived Cells Are Disposed of, Mediated by C-Reactive Protein-Including a Treatment Option"
240:
215:
72:
6275:
6108:
5112:
4317:
Vermeire S, Van Assche G, Rutgeerts P (September 2004). "C-reactive protein as a marker for inflammatory bowel disease".
2012:
5798:
4273:
1777:
1214:
157:
1533:
Measuring and charting CRP values can prove useful in determining disease progress or the effectiveness of treatments.
6285:
6213:
4903:"Clinical Characteristics of 138 Hospitalized Patients With 2019 Novel Coronavirus-Infected Pneumonia in Wuhan, China"
1712:
1501:
CRP concentrations between 2 and 10 mg/L are considered as metabolic inflammation: metabolic pathways that cause
1478:
5507:
5422:
5096:
3915:"Effect of hydroxymethyl glutaryl coenzyme a reductase inhibitor therapy on high sensitive C-reactive protein levels"
4081:"Baseline serum C-reactive protein is associated with lipid responses to low-fat and high-polyunsaturated fat diets"
6300:
5606:
5071:
1805:
1720:
354:
253:
4450:
Allin KH, Nordestgaard BG (2011). "Elevated C-reactive protein in the diagnosis, prognosis, and cause of cancer".
6147:
6062:
5396:
5202:
5160:
1801:
1506:
1147:
1614:). ESR may be normal while CRP is elevated. CRP returns to normal more quickly than ESR in response to therapy.
347:
246:
6168:
5673:
5081:
3665:
1844:
1238:
893:
165:
4760:
Ammitzbøll CG, Steffensen R, Bøgsted M, Hørslev-Petersen K, Hetland ML, Junker P, et al. (October 2014).
3612:"C-reactive protein and other circulating markers of inflammation in the prediction of coronary heart disease"
3571:"Consumption of trans fatty acids is related to plasma biomarkers of inflammation and endothelial dysfunction"
5956:
2970:
2948:"Comparison of C-reactive protein and high-sensitivity C-reactive protein levels in patients on hemodialysis"
2405:"Erythrocyte Sedimentation Rate and C-reactive Protein Measurements and Their Relevance in Clinical Medicine"
1972:
5733:
3721:"The Potential Role of C-Reactive Protein in Metabolic-Dysfunction-Associated Fatty Liver Disease and Aging"
1865:
1685:
1546:
1175:
874:
5391:
3349:
Dittrich S, Tadesse BT, Moussy F, Chua A, Zorzet A, Tängdén T, et al. (2016-08-25). Yansouni C (ed.).
2504:
5538:
1631:
1538:
1422:
5526:
1888:(RA), CRP is one of the acute phase reactants, whose assessment is defined as part of the joint 2010 ACR/
6178:
5759:
5374:
4691:
4638:
Carrier N, Marotta A, de Brum-Fernandes AJ, Liang P, Masetto A, MĂ©nard HA, et al. (February 2016).
1797:
1655:
1276:
31:
3528:
Dehghan A, Kardys I, de Maat MP, Uitterlinden AG, Sijbrands EJ, Bootsma AH, et al. (March 2007).
3015:"Metabolic and scintigraphic studies of radioiodinated human C-reactive protein in health and disease"
1178:
expressed on the surface of dead or dying cells (and some types of bacteria) in order to activate the
6280:
6016:
5832:
5521:
5153:
3677:
3362:
1902:, diabetes and interstitial lung (pulmonary) disease. Mechanistically, CRP also appears to influence
1885:
1869:
1651:
1622:
Recent research suggests that patients with elevated basal levels of CRP are at an increased risk of
1580:
1453:
1348:
1316:
229:
5326:
3664:
Pepys MB, Hirschfield GM, Tennent GA, Gallimore JR, Kahan MC, Bellotti V, et al. (April 2006).
144:
6270:
6239:
6173:
6131:
6011:
5951:
5697:
5687:
5677:
5494:
5354:
5297:
5279:
5118:
3821:
Ridker PM, Danielson E, Fonseca FA, Genest J, Gotto AM, Kastelein JJ, et al. (November 2008).
2905:
Pearson TA, Mensah GA, Alexander RW, Anderson JL, Cannon RO, Criqui M, et al. (January 2003).
1659:
1332:
1155:
1034:
1030:
1026:
975:
971:
967:
17:
4251:
4130:"Narrative review: Assessment of C-reactive protein in risk prediction for cardiovascular disease"
5929:
5379:
4742:
4679:
4475:
4360:
Sidore C, Busonero F, Maschio A, Porcu E, Naitza S, Zoledziewska M, et al. (November 2015).
4342:
3701:
3610:
Danesh J, Wheeler JG, Hirschfield GM, Eda S, Eiriksdottir G, Rumley A, et al. (April 2004).
3569:
Lopez-Garcia E, Schulze MB, Meigs JB, Manson JE, Rifai N, Stampfer MJ, et al. (March 2005).
3469:
2254:
1899:
1813:
1788:
is present. Elevations of CRP in the absence of clinically significant inflammation can occur in
1542:
1445:
1226:
1139:
189:
1809:
1055:
1022:
996:
963:
5067:
4580:"The Relationship between Obstructive Sleep Apnea and Atrial Fibrillation: A Complex Interplay"
4227:
6046:
5946:
5889:
5340:
5125:
5077:
5036:
4985:
4934:
4883:
4834:
4793:
4734:
4671:
4611:
4557:
4516:
4467:
4432:
4391:
4334:
4285:
4231:
4200:
4151:
4110:
4061:
4020:
3985:
3936:
3895:
3844:
3803:
3752:
3693:
3633:
3592:
3551:
3510:
3461:
3422:
3390:
3331:
3267:
3226:
3175:
3134:
3085:
3044:
2962:
2928:
2826:
2775:
2726:
2675:
2624:
2573:
2468:
2419:
2404:
2376:
2351:
2326:
2303:
2246:
2211:
2173:
2109:
1527:
1470:
1449:
1367:
1296:
1234:
1179:
137:
65:
4038:
Zacho J, Tybjaerg-Hansen A, Jensen JS, Grande P, Sillesen H, Nordestgaard BG (October 2008).
3193:
Enocsson H, Gullstrand B, Eloranta ML, Wetterö J, Leonard D, Rönnblom L, et al. (2020).
2088:"The physiological structure of human C-reactive protein and its complex with phosphocholine"
5629:
5439:
5429:
5408:
5226:: Crystal structure of calcium-depleted human C-reactive protein from perfectly twinned data
5026:
5016:
4975:
4965:
4924:
4914:
4873:
4865:
4824:
4783:
4773:
4724:
4661:
4651:
4601:
4591:
4547:
4506:
4459:
4422:
4381:
4373:
4326:
4219:
4190:
4182:
4146:
4141:
4129:
4100:
4092:
4051:
4012:
3975:
3967:
3926:
3885:
3875:
3834:
3793:
3783:
3742:
3732:
3685:
3623:
3582:
3541:
3500:
3453:
3414:
3380:
3370:
3321:
3311:
3257:
3216:
3206:
3165:
3124:
3116:
3075:
3034:
3026:
2918:
2873:"The Application of High-Sensitivity C-Reactive Protein in Clinical Practice: A 2015 Update"
2816:
2806:
2765:
2757:
2716:
2706:
2665:
2655:
2614:
2604:
2563:
2553:
2458:
2450:
2293:
2285:
2238:
2203:
2163:
2155:
2099:
1824:
1502:
1340:
1272:
434:
365:
309:
264:
3823:"Rosuvastatin to prevent vascular events in men and women with elevated C-reactive protein"
6193:
6152:
5788:
5709:
5477:
5312:
5302:
5100:
4713:"C-reactive protein and implications in rheumatoid arthritis and associated comorbidities"
3770:
Torzewski J, Brunner P, Ries W, Garlichs CD, Kayser S, Heigl F, et al. (March 2022).
2880:
2847:
1984:
1907:
1773:
1610:
CRP is a more sensitive and accurate reflection of the acute phase response than the ESR (
1576:
1375:
1336:
409:
4534:
Baron JA, Cole BF, Sandler RS, Haile RW, Ahnen D, Bresalier R, et al. (March 2003).
3105:"Inflammatory markers and risk of type 2 diabetes: a systematic review and meta-analysis"
2486:
185:
3747:
3720:
3681:
3366:
2670:
2643:
2540:
Enocsson H, Karlsson J, Li HY, Wu Y, Kushner I, Wetterö J, et al. (December 2021).
2274:"Serological Reactions in Pneumonia with a Non-Protein Somatic Fraction of Pneumococcus"
592:
5904:
5861:
5778:
5683:
5669:
5649:
5031:
5005:"Therapeutic and triage strategies for 2019 novel coronavirus disease in fever clinics"
5004:
4980:
4953:
4929:
4902:
4878:
4853:
4788:
4761:
4666:
4639:
4606:
4579:
4386:
4361:
4195:
4170:
4105:
4080:
3980:
3955:
3890:
3863:
3798:
3771:
3385:
3350:
3326:
3299:
3221:
3194:
3129:
3104:
3080:
3063:
2923:
2906:
2821:
2794:
2770:
2745:
2721:
2694:
2619:
2592:
2568:
2541:
2463:
2438:
2298:
2273:
1789:
1591:
1579:(10–40 mg/L), active inflammation, bacterial infection (40–200 mg/L), severe
1482:
1288:
1268:
1248:
599:
5021:
4970:
3971:
3039:
3014:
2946:
Helal I, Zerelli L, Krid M, ElYounsi F, Ben Maiz H, Zouari B, et al. (May 2012).
2403:
Bray C, Bell LN, Liang H, Haykal R, Kaiksow F, Mazza JJ, et al. (December 2016).
2168:
2143:
2104:
2087:
1668:
It has been hypothesized that patients with high CRP levels might benefit from use of
1549:
is typically used for hsCRP.Cutoffs for cardiovascular risk assessment have included:
763:
758:
753:
748:
743:
738:
733:
728:
723:
718:
702:
697:
681:
676:
671:
666:
661:
656:
651:
646:
641:
6259:
6188:
6021:
6003:
5941:
5899:
5895:
5727:
5587:
5546:
5502:
5465:
5434:
5366:
5348:
5236:
5134:
4746:
4729:
4712:
4330:
4220:
2439:"C-reactive protein is protective against Streptococcus pneumoniae infection in mice"
1750:
1692:
1681:
1673:
1523:
1457:
1320:
1163:
628:
4479:
4346:
4186:
3489:"C-reactive protein, interleukin 6, and risk of developing type 2 diabetes mellitus"
3152:
Enocsson H, Sjöwall C, Skogh T, Eloranta ML, Rönnblom L, Wetterö J (December 2009).
2258:
1757:, hypertension and diabetes also increase the risk level of cardiovascular disease.
5693:
5637:
5471:
5458:
5403:
5334:
4683:
3705:
3473:
1958:
1848:
1769:
1708:
1654:-dependent fashion and that CRP inhibition can be a safe and effective therapy for
1627:
1603:
1590:
CRP cut-off levels indicating bacterial from non-bacterial illness can vary due to
1572:
1427:
1398:
1355:; and tissue injury and necrosis. These conditions cause release of IL-6 and other
1300:
1252:
1151:
1143:
427:
206:
5062:
4427:
4410:
1864:
C-reactive protein (CRP), a marker of systemic inflammation, is also increased in
1741:
But hs-CRP is not to be used alone and should be combined with elevated levels of
169:
4463:
3737:
3457:
3375:
3246:"Four immunochemical methods for measuring C-reactive protein in plasma compared"
2695:"Special Issue "C-Reactive Protein and Cardiovascular Disease: Clinical Aspects""
2660:
1331:
in response to a wide range of acute and chronic inflammatory conditions such as
193:
6244:
6223:
6208:
6052:
6042:
5934:
5885:
5822:
5803:
5763:
5752:
5720:
5561:
5484:
5057:
3262:
3245:
2207:
2073:
National Center for
Biotechnology Information, U.S. National Library of Medicine
2055:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1765:
1742:
1441:
4829:
4812:
3931:
3914:
2761:
1370:
binding to foreign and damaged cells and enhances phagocytosis by macrophages (
510:
5983:
5320:
5267:
4869:
4778:
4656:
4016:
3772:"Targeting C-Reactive Protein by Selective Apheresis in Humans: Pros and Cons"
3211:
2609:
2242:
1903:
1704:
1490:
1474:
1360:
1352:
1324:
1264:
1237:
which gave a positive or a negative result. More precise methods nowadays use
1198:
1194:
1167:
326:
223:
173:
4293:
3913:
Jialal I, Stein D, Balis D, Grundy SM, Adams-Huet B, Devaraj S (April 2001).
3103:
Wang X, Bao W, Liu J, Ouyang YY, Wang D, Rong S, et al. (January 2013).
2811:
1776:
elicit little or no CRP response. CRP levels also tend not to be elevated in
6218:
5988:
5975:
5847:
5827:
5271:
3880:
3316:
2522:
1943:
1930:
1785:
1781:
1639:
1568:
1344:
1328:
1308:
1245:
1210:
1206:
1202:
793:
570:
448:
393:
380:
292:
279:
181:
5040:
4989:
4938:
4919:
4887:
4838:
4797:
4738:
4675:
4615:
4561:
4520:
4511:
4494:
4471:
4436:
4395:
4338:
4289:
4274:"C-reactive protein: a new risk assessment tool for cardiovascular disease"
4204:
4155:
4114:
4065:
4024:
3989:
3940:
3899:
3848:
3807:
3756:
3697:
3637:
3596:
3587:
3570:
3555:
3514:
3505:
3488:
3465:
3426:
3394:
3335:
3230:
3179:
3138:
3089:
2966:
2932:
2830:
2779:
2730:
2679:
2628:
2577:
2454:
2423:
2307:
2250:
2215:
2177:
2113:
1366:
CRP binds to phosphocholine on micro-organisms. It is thought to assist in
5093:
4952:
Chen N, Zhou M, Dong X, Qu J, Gong F, Han Y, et al. (February 2020).
4596:
4096:
4056:
4039:
3839:
3822:
3666:"Targeting C-reactive protein for the treatment of cardiovascular disease"
3271:
3048:
2472:
1819:
High levels of CRP has been associated to point mutation Cys130Arg in the
1119:
1114:
48:
6198:
5869:
5837:
5640:
5566:
5556:
5287:
4552:
4535:
3628:
3611:
3530:"Genetic variation, C-reactive protein levels, and incidence of diabetes"
2289:
1954:
1926:
1915:
1647:
1644:
1635:
1623:
1486:
1356:
1304:
1292:
1103:
938:
919:
3788:
3689:
2711:
2558:
2542:"The Complex Role of C-Reactive Protein in Systemic Lupus Erythematosus"
2371:
Ratey JJ, Noskin GA, Braun R, Hanley EN Jr, McInnes IB, Ruddy S (2008).
6139:
6100:
5966:
5909:
5842:
5551:
5515:
5416:
5139:
5129:
4040:"Genetically elevated C-reactive protein and ischemic vascular disease"
1754:
1669:
1662:
1595:
1371:
1159:
905:
860:
5068:
Inflammation, Heart
Disease and Stroke: The Role of C-Reactive Protein
4811:
Wu W, Shi D, Fang D, Guo F, Guo J, Huang F, et al. (March 2016).
3546:
3529:
3418:
3170:
3153:
3120:
3030:
114:
110:
106:
102:
98:
94:
6203:
5993:
5659:
5452:
4901:
Wang D, Hu B, Hu C, Zhu F, Liu X, Zhang J, et al. (March 2020).
2746:"[CRP apheresis in acute myocardial infarction and COVID-19]"
2437:
Mold C, Nakayama S, Holzer TJ, Gewurz H, Du Clos TW (November 1981).
2159:
1876:) significantly alleviated the effect of OSA on CRP and IL-6 levels.
1852:
risk of colon cancer, concurring with previous studies that indicate
1840:
polymorphisms influencing circulating levels of CRP and cancer risk.
1793:
1230:
1171:
1087:
815:
5598:
4377:
5090:- The Association for Clinical Biochemistry and Laboratory Medicine
2795:"Role of C-Reactive Protein at Sites of Inflammation and Infection"
744:
negative regulation of macrophage derived foam cell differentiation
6057:
5384:
4171:"Within-person variability in high-sensitivity C-reactive protein"
3862:
Sindhu S, Singh HK, Salman MT, Fatima J, Verma VK (October 2011).
3487:
Pradhan AD, Manson JE, Rifai N, Buring JE, Ridker PM (July 2001).
1911:
1894:
1828:
1746:
1564:
1534:
1526:, there are few known factors that interfere with CRP production.
1190:
1291:
expressed on the surface of bacterial cells such as pneumococcus
778:
774:
148:, PTX1, C-reactive protein, pentraxin-related, C-Reactive Protein
2196:
American
Journal of Physiology. Heart and Circulatory Physiology
1950:
1946:
1584:
161:
6104:
5602:
5240:
5149:
4495:"C-reactive protein and the risk of incident colorectal cancer"
4493:
Erlinger TP, Platz EA, Rifai N, Helzlsouer KJ (February 2004).
2348:
Henry's clinical diagnosis and management by laboratory methods
1691:
To clarify whether CRP is a bystander or active participant in
608:
5145:
5003:
Zhang J, Zhou L, Yang Y, Peng W, Wang W, Chen X (March 2020).
4536:"A randomized trial of aspirin to prevent colorectal adenomas"
1634:. A study of over 700 nurses showed that those in the highest
1599:
1183:
3719:
Ding Z, Wei Y, Peng J, Wang S, Chen G, Sun J (October 2023).
1847:
on colon cancer risk associated with CRP levels, people with
5124:
Overview of all the structural information available in the
4854:"C-reactive protein as a biomarker of severe H1N1 influenza"
4813:"A new perspective on C-reactive protein in H7N9 infections"
3652:"C-reactive protein - a critical cardiovascular risk marker"
4226:(24th ed.). Philadelphia: Elsevier Saunders. pp.
2593:"C-Reactive Protein Triggers Cell Death in Ischemic Cells"
1665:; this has been demonstrated in animal models and humans.
4169:
Bower JK, Lazo M, Juraschek SP, Selvin E (October 2012).
4079:
St-Onge MP, Zhang S, Darnell B, Allison DB (April 2009).
1522:
CRP is used mainly as an inflammation marker. Apart from
1473:. Other inflammatory mediators that can increase CRP are
5196:: HUMAN C-REACTIVE PROTEIN COMPLEXED WITH PHOSPHOCHOLINE
4128:
Lloyd-Jones DM, Liu K, Tian L, Greenland P (July 2006).
2523:"Human C-reactive protein complexed with phosphocholine"
1374:), which express a receptor for CRP. It plays a role in
417:
2750:
Medizinische Klinik, Intensivmedizin und Notfallmedizin
2321:
Kennelly PJ, Murray RF, Rodwell VW, Botham KM (2009).
1942:
Increased blood CRP levels were higher in people with
1213:(blood coagulation). C-reactive protein was the first
2642:
Sheriff A, Kunze R, Brunner P, Vogt B (August 2023).
582:
2955:
Saudi Journal of Kidney Diseases and Transplantation
6232:
6161:
6138:
6030:
6002:
5974:
5965:
5922:
5878:
5860:
5813:
5786:
5777:
5742:
5707:
5657:
5648:
5636:
5575:
5537:
5493:
5365:
5278:
4312:
4310:
4278:
The Journal of the American Osteopathic Association
2842:
2840:
1405:
1393:
1388:
1319:occurs as a result of increasing concentrations of
1048:
1015:
989:
956:
3868:Journal of Pharmacology & Pharmacotherapeutics
3068:Arteriosclerosis, Thrombosis, and Vascular Biology
2029:
2027:
2025:
2008:
2006:
2004:
724:positive regulation of superoxide anion generation
5094:George Vrousgos, N.D. - Southern Cross University
4696:: CS1 maint: DOI inactive as of September 2024 (
4411:"Inflammation, a key event in cancer development"
3064:"CRP--marker or maker of cardiovascular disease?"
642:low-density lipoprotein particle receptor binding
364:
263:
4452:Critical Reviews in Clinical Laboratory Sciences
3013:Vigushin DM, Pepys MB, Hawkins PN (April 1993).
1804:. Elevated level of CRP can also be observed in
5308:Fluorescent treponemal antibody absorption test
4573:
4571:
3438:
3436:
2900:
2898:
2896:
2744:Buerke M, Sheriff A, Garlichs CD (April 2022).
2591:Sheriff A, Kayser S, Brunner P, Vogt B (2021).
2086:Thompson D, Pepys MB, Wood SP (February 1999).
1378:as an early defense system against infections.
2034:GRCm38: Ensembl release 89: ENSMUSG00000037942
1541:methods are available for research use, while
6116:
5614:
5252:
5161:
1241:after reaction with CRP-specific antibodies.
8:
4817:International Journal of Infectious Diseases
3446:The American Journal of the Medical Sciences
2398:
2396:
2394:
2392:
1831:values and inflammatory markers modulation.
1684:of 20 studies involving 1,466 patients with
2013:GRCh38: Ensembl release 89: ENSG00000132693
1677:was useful for determining statin benefit.
754:defense response to Gram-positive bacterium
6123:
6109:
6101:
5971:
5783:
5654:
5645:
5621:
5607:
5599:
5259:
5245:
5237:
5168:
5154:
5146:
4578:Latina JM, Estes NA, Garlitski AC (2013).
3244:GrĂĽtzmeier S, von Schenck H (March 1989).
2346:Pincus MR, McPherson RA, Henry JB (2007).
1725:Centers for Disease Control and Prevention
789:
624:
405:
304:
201:
83:
6089:disorders of globin and globulin proteins
5293:Venereal Disease Research Laboratory test
5080:at the U.S. National Library of Medicine
5030:
5020:
4979:
4969:
4928:
4918:
4877:
4828:
4787:
4777:
4728:
4665:
4655:
4605:
4595:
4551:
4510:
4426:
4385:
4194:
4145:
4104:
4055:
3979:
3930:
3889:
3879:
3838:
3797:
3787:
3746:
3736:
3627:
3586:
3545:
3504:
3384:
3374:
3325:
3315:
3304:Journal of Emergencies, Trauma, and Shock
3261:
3220:
3210:
3169:
3128:
3079:
3038:
2922:
2820:
2810:
2769:
2720:
2710:
2669:
2659:
2618:
2608:
2567:
2557:
2462:
2297:
2167:
2103:
1205:family of proteins. It is not related to
2272:Tillett WS, Francis T (September 1930).
759:complement activation, classical pathway
672:low-density lipoprotein particle binding
657:complement component C1q complex binding
5183:
4147:10.7326/0003-4819-145-1-200607040-00129
2144:"C-reactive protein: a critical update"
2137:
2135:
2133:
2131:
2129:
2127:
2125:
2123:
2000:
1968:
1921:It has previously been speculated that
1174:. Its physiological role is to bind to
4689:
4409:Lu H, Ouyang W, Huang C (April 2006).
2142:Pepys MB, Hirschfield GM (June 2003).
1556:average: between 1.0 and 3.0 mg/L
1385:
1359:that trigger the synthesis of CRP and
729:positive regulation of gene expression
38:
4852:Vasileva D, Badawi A (January 2019).
3019:The Journal of Clinical Investigation
2189:
2187:
2148:The Journal of Clinical Investigation
1727:have defined risk groups as follows:
1553:low: hs-CRP level under 1.0 mg/L
369:
330:
325:
268:
227:
222:
7:
4717:Seminars in Arthritis and Rheumatism
3288:. TH-Books, Frankfurt, 2008, p. 1010
2443:The Journal of Experimental Medicine
2278:The Journal of Experimental Medicine
1872:score. Treatment of OSA with CPAP (
719:negative regulation of lipid storage
4540:The New England Journal of Medicine
4044:The New England Journal of Medicine
3827:The New England Journal of Medicine
3616:The New England Journal of Medicine
1874:continuous positive airway pressure
1193:in response to factors released by
18:High-sensitivity C-reactive protein
6296:Diagnostic intensive care medicine
4711:Pope JE, Choy EH (February 2021).
3081:10.1161/01.ATV.0000174796.81443.3f
2924:10.1161/01.cir.0000052939.59093.45
1734:Average risk: 1.0 to 3.0 mg/L
1567:. Higher levels are found in late
1045:
1012:
986:
953:
929:
910:
884:
865:
839:
820:
587:
505:
443:
422:
25:
2793:Sproston NR, Ashworth JJ (2018).
2323:Harper's illustrated biochemistry
1731:Low Risk: less than 1.0 mg/L
27:Mammalian protein found in humans
5216:
5201:
5186:
5009:The Lancet. Respiratory Medicine
4766:Arthritis Research & Therapy
4730:10.1016/j.semarthrit.2020.11.005
4644:Arthritis Research & Therapy
4331:10.1097/00054725-200409000-00026
4272:Clearfield MB (September 2005).
2491:HUGO Gene Nomenclature Committee
1983:
1971:
1162:origin that increases following
598:
591:
541:lumbar subsegment of spinal cord
353:
346:
340:
317:
252:
245:
239:
214:
47:
4187:10.1001/archinternmed.2012.3712
2871:Knight ML (February 18, 2015).
1923:single-nucleotide polymorphisms
1914:expression in peripheral blood
1856:could lower colon cancer risk.
1545:is used clinically for CRP and
1409:The amount of CRP in the blood.
6068:Extracellular matrix protein 1
5445:Orthopoxvirus inclusion bodies
3411:Journal of Nursing Scholarship
2487:"Gene group: Short pentraxins"
2231:Journal of Clinical Immunology
1827:, establishing a link between
1737:High risk: above 3.0 mg/L
1612:erythrocyte sedimentation rate
1444:conditions. There are also no
1138:) is an annular (ring-shaped)
609:More reference expression data
571:More reference expression data
1:
5022:10.1016/S2213-2600(20)30071-0
4971:10.1016/S0140-6736(20)30211-7
4428:10.1158/1541-7786.MCR-05-0261
4175:Archives of Internal Medicine
3972:10.1016/S0140-6736(10)62174-5
2105:10.1016/S0969-2126(99)80023-9
1703:Arterial damage results from
1372:opsonin-mediated phagocytosis
1323:(IL-6), which is produced by
1303:by macrophages, which clears
338:
237:
5799:Sex hormone-binding globulin
5138:(C-reactive protein) at the
4464:10.3109/10408363.2011.599831
3776:Journal of Clinical Medicine
3738:10.3390/biomedicines11102711
3458:10.1097/MAJ.0b013e3182959a18
3376:10.1371/journal.pone.0161721
2699:Journal of Clinical Medicine
2661:10.3390/biomedicines11082279
2546:Journal of Clinical Medicine
1778:systemic lupus erythematosus
1563:Normal levels increase with
1263:It is a member of the small
1215:pattern recognition receptor
6266:Genes on human chromosome 1
6214:Haptoglobin-related protein
4319:Inflammatory Bowel Diseases
4134:Annals of Internal Medicine
2527:Protein Data Bank in Europe
2208:10.1152/ajpheart.01058.2004
1802:peripheral vascular disease
1699:Coronary heart disease risk
1479:tumor necrosis factor alpha
6317:
5211:: HUMAN C-REACTIVE PROTEIN
5117:gene details page in the
5072:American Heart Association
4830:10.1016/j.ijid.2016.01.009
3932:10.1161/01.CIR.103.15.1933
2848:"C-Reactive Protein (CRP)"
2762:10.1007/s00063-022-00911-x
2375:. Philadelphia: Saunders.
1806:inflammatory bowel disease
1721:American Heart Association
1189:CRP is synthesized by the
1148:circulating concentrations
529:sexually immature organism
483:pancreatic epithelial cell
29:
6080:
6063:Vitamin D-binding protein
5397:Heterophile antibody test
5181:
4870:10.1007/s00011-018-1188-x
4779:10.1186/s13075-014-0475-3
4657:10.1186/s13075-016-0935-z
4415:Molecular Cancer Research
4017:10.1016/j.ahj.2011.12.017
3650:Koenig, Wolfgang (2006).
3263:10.1093/clinchem/35.3.461
3212:10.3389/fimmu.2020.622326
3062:Nilsson J (August 2005).
2610:10.3389/fimmu.2021.630430
2243:10.1007/s10875-007-9126-7
2069:"Mouse PubMed Reference:"
2051:"Human PubMed Reference:"
1761:Fibrosis and inflammation
1559:high: above 3.0 mg/L
1507:type II diabetes mellitus
1201:). It is a member of the
1197:, T cells and fat cells (
1118:
1113:
1109:
1102:
1086:
1080:Chr 1: 172.53 – 172.66 Mb
1073:Chr 1: 159.71 – 159.71 Mb
1067:
1052:
1019:
1008:
993:
960:
949:
936:
932:
917:
913:
904:
891:
887:
872:
868:
859:
846:
842:
827:
823:
814:
799:
792:
788:
772:
682:identical protein binding
627:
623:
606:
590:
581:
568:
517:
508:
455:
446:
416:
408:
404:
387:
374:
337:
316:
307:
303:
286:
273:
236:
213:
204:
200:
155:
152:
142:
135:
130:
91:
86:
69:
64:
59:
55:
46:
41:
6169:Alpha 1-antichymotrypsin
5674:Alpha 1-antichymotrypsin
5082:Medical Subject Headings
5058:MedlinePlus Encyclopedia
4222:Goldman's Cecil Medicine
4085:The Journal of Nutrition
3575:The Journal of Nutrition
3158:Arthritis and Rheumatism
2812:10.3389/fimmu.2018.00754
1845:prospective cohort study
1239:dynamic light scattering
1217:(PRR) to be identified.
30:Not to be confused with
5957:7S seed storage protein
5734:Retinol binding protein
4660:(inactive 2024-09-17).
3881:10.4103/0976-500X.85954
3317:10.4103/0974-2700.96477
3199:Frontiers in Immunology
2799:Frontiers in Immunology
2693:Sheriff A (June 2022).
2597:Frontiers in Immunology
2325:. McGraw-Hill Medical.
1949:compared to those with
1866:obstructive sleep apnea
1860:Obstructive sleep apnea
1854:anti-inflammatory drugs
1686:coronary artery disease
1672:. This is based on the
1448:of CRP concentrations.
1176:lysophosphatidylcholine
5539:Bloodstream infections
5508:Sabin–Feldman dye test
5423:Warthin–Finkeldey cell
5088:CRP: analyte monograph
4920:10.1001/jama.2020.1585
4512:10.1001/jama.291.5.585
4005:American Heart Journal
3506:10.1001/jama.286.3.327
3298:Chew KS (April 2012).
2455:10.1084/jem.154.5.1703
1632:cardiovascular disease
1618:Cardiovascular disease
1539:radial immunodiffusion
1497:Metabolic inflammation
1423:cardiovascular disease
1271:, which is removed by
1259:Genetics and structure
1251:(C-polysaccharide) of
764:innate immune response
549:lumbar spinal ganglion
6291:Diagnostic cardiology
6179:Alpha 2-macroglobulin
5760:alpha-2-Macroglobulin
4858:Inflammation Research
4097:10.3945/jn.108.098251
4057:10.1056/NEJMoa0707402
3840:10.1056/NEJMoa0807646
2350:. Saunders Elsevier.
1798:myocardial infarction
1753:, and glucose level.
1587:(>200 mg/L).
1513:Clinical significance
1349:inflammatory diseases
1295:. This activates the
1221:History and etymology
734:inflammatory response
487:right coronary artery
32:cAMP receptor protein
6276:Acute-phase proteins
6132:Acute-phase proteins
6017:Bovine serum albumin
5833:Beta-2 microglobulin
5522:Diagnosis of malaria
5111:genome location and
4553:10.1056/NEJMoa021735
3629:10.1056/NEJMoa032804
3588:10.1093/jn/135.3.562
2290:10.1084/jem.52.4.561
1961:, had elevated CRP.
1910:and also stimulates
1906:activity leading to
1886:rheumatoid arthritis
1880:Rheumatoid arthritis
1870:apnea-hypopnea index
1581:bacterial infections
1454:interleukin-1 family
1317:acute phase response
1150:rise in response to
739:acute-phase response
698:extracellular region
371:1 H3|1 80.13 cM
332:Chromosome 1 (mouse)
230:Chromosome 1 (human)
87:List of PDB id codes
60:Available structures
6174:Alpha 1-antitrypsin
6012:Human serum albumin
5952:11S globulin family
5698:Heparin cofactor II
5688:Alpha 2-antiplasmin
5678:Alpha 1-antitrypsin
5495:Protozoan infection
5355:Anti-streptolysin O
5298:rapid plasma reagin
5280:Bacterial infection
5119:UCSC Genome Browser
4597:10.1155/2013/621736
3789:10.3390/jcm11071771
3690:10.1038/nature04672
3682:2006Natur.440.1217P
3676:(7088): 1217–1221.
3367:2016PLoSO..1161721D
2712:10.3390/jcm11133610
2559:10.3390/jcm10245837
2509:NCBI Entrez Protein
1446:seasonal variations
1416:Measurement methods
1156:acute-phase protein
703:extracellular space
647:calcium ion binding
495:epithelium of colon
463:islet of Langerhans
459:right lobe of liver
6286:Chemical pathology
6184:C-reactive protein
6038:C-reactive protein
5930:Beta-lactoglobulin
5583:C-reactive protein
5392:Epstein–Barr virus
5380:Branched DNA assay
5272:infectious disease
5099:2020-02-18 at the
5078:C-Reactive+Protein
5063:C-reactive protein
4964:(10223): 507–513.
4584:Pulmonary Medicine
4218:Goldman L (2011).
4011:(4): 666–76.e1–3.
3286:Labor und Diagnose
3250:Clinical Chemistry
2202:(5): H2031–H2041.
1990:C-reactive protein
1978:C-reactive protein
1900:metabolic syndrome
1884:In the context of
1814:ulcerative colitis
1543:immunoturbidimetry
1471:allergic reactions
1464:Acute inflammation
1389:C-reactive protein
1140:pentameric protein
1132:C-reactive protein
894:ENSMUSG00000037942
712:Biological process
691:Cellular component
635:Molecular function
521:left lobe of liver
6301:Immunologic tests
6253:
6252:
6098:
6097:
6076:
6075:
6047:Alpha-lactalbumin
5947:Alpha-lactalbumin
5918:
5917:
5890:Fetal fibronectin
5856:
5855:
5773:
5772:
5630:Globular proteins
5596:
5595:
5341:HelicoCARE direct
5234:
5233:
4913:(11): 1061–1069.
4372:(11): 1272–1281.
4181:(19): 1519–1521.
4050:(18): 1897–1908.
3966:(9764): 469–476.
3925:(15): 1933–1935.
3833:(21): 2195–2207.
3622:(14): 1387–1397.
3547:10.2337/db06-0922
3419:10.1111/jnu.13002
3171:10.1002/art.25042
3164:(12): 3755–3760.
3121:10.2337/dc12-0702
3031:10.1172/JCI116336
2382:978-1-4160-3285-4
2357:978-1-4160-0287-1
2332:978-0-07-162591-3
2154:(12): 1805–1812.
1965:Additional images
1823:gene, coding for
1808:(IBD), including
1450:Gene polymorphism
1413:
1412:
1297:complement system
1287:CRP binds to the
1235:quellung reaction
1180:complement system
1129:
1128:
1125:
1124:
1098:
1097:
1063:
1062:
1042:
1041:
1004:
1003:
983:
982:
945:
944:
926:
925:
900:
899:
881:
880:
855:
854:
836:
835:
784:
783:
667:metal ion binding
619:
618:
615:
614:
577:
576:
564:
563:
502:
501:
400:
399:
299:
298:
126:
125:
122:
121:
70:Ortholog search:
16:(Redirected from
6308:
6125:
6118:
6111:
6102:
5972:
5816:
5792:
5789:carrier proteins
5784:
5745:
5713:
5710:carrier proteins
5663:
5655:
5646:
5623:
5616:
5609:
5600:
5527:SchĂĽffner's dots
5440:B type inclusion
5430:Inclusion bodies
5409:NS1 antigen test
5261:
5254:
5247:
5238:
5220:
5205:
5190:
5170:
5163:
5156:
5147:
5045:
5044:
5034:
5024:
5000:
4994:
4993:
4983:
4973:
4949:
4943:
4942:
4932:
4922:
4898:
4892:
4891:
4881:
4849:
4843:
4842:
4832:
4808:
4802:
4801:
4791:
4781:
4757:
4751:
4750:
4732:
4708:
4702:
4701:
4695:
4687:
4669:
4659:
4635:
4629:
4626:
4620:
4619:
4609:
4599:
4575:
4566:
4565:
4555:
4531:
4525:
4524:
4514:
4490:
4484:
4483:
4447:
4441:
4440:
4430:
4406:
4400:
4399:
4389:
4357:
4351:
4350:
4314:
4305:
4304:
4302:
4301:
4292:. Archived from
4269:
4263:
4262:
4260:
4258:
4248:
4242:
4241:
4225:
4215:
4209:
4208:
4198:
4166:
4160:
4159:
4149:
4125:
4119:
4118:
4108:
4076:
4070:
4069:
4059:
4035:
4029:
4028:
4000:
3994:
3993:
3983:
3951:
3945:
3944:
3934:
3910:
3904:
3903:
3893:
3883:
3859:
3853:
3852:
3842:
3818:
3812:
3811:
3801:
3791:
3767:
3761:
3760:
3750:
3740:
3716:
3710:
3709:
3661:
3655:
3654:. CRPhealth.com.
3648:
3642:
3641:
3631:
3607:
3601:
3600:
3590:
3566:
3560:
3559:
3549:
3525:
3519:
3518:
3508:
3484:
3478:
3477:
3440:
3431:
3430:
3405:
3399:
3398:
3388:
3378:
3346:
3340:
3339:
3329:
3319:
3295:
3289:
3284:Thomas, Lothar,
3282:
3276:
3275:
3265:
3241:
3235:
3234:
3224:
3214:
3190:
3184:
3183:
3173:
3149:
3143:
3142:
3132:
3100:
3094:
3093:
3083:
3074:(8): 1527–1528.
3059:
3053:
3052:
3042:
3025:(4): 1351–1357.
3010:
3004:
3001:
2995:
2991:
2985:
2984:
2982:
2981:
2975:
2969:. Archived from
2952:
2943:
2937:
2936:
2926:
2902:
2891:
2890:
2888:
2887:
2868:
2862:
2861:
2859:
2858:
2852:Lab Tests Online
2844:
2835:
2834:
2824:
2814:
2790:
2784:
2783:
2773:
2741:
2735:
2734:
2724:
2714:
2690:
2684:
2683:
2673:
2663:
2639:
2633:
2632:
2622:
2612:
2588:
2582:
2581:
2571:
2561:
2537:
2531:
2530:
2519:
2513:
2512:
2501:
2495:
2494:
2483:
2477:
2476:
2466:
2449:(5): 1703–1708.
2434:
2428:
2427:
2409:
2400:
2387:
2386:
2368:
2362:
2361:
2343:
2337:
2336:
2318:
2312:
2311:
2301:
2269:
2263:
2262:
2226:
2220:
2219:
2191:
2182:
2181:
2171:
2160:10.1172/JCI18921
2139:
2118:
2117:
2107:
2083:
2077:
2076:
2065:
2059:
2058:
2047:
2041:
2031:
2020:
2010:
1987:
1975:
1938:Viral infections
1825:apolipoprotein E
1705:white blood cell
1577:viral infections
1528:Interferon alpha
1503:arteriosclerosis
1386:
1273:signal peptidase
1111:
1110:
1082:
1075:
1058:
1046:
1037:
1013:
1009:RefSeq (protein)
999:
987:
978:
954:
930:
911:
885:
866:
840:
821:
790:
625:
611:
602:
595:
588:
573:
557:digastric muscle
525:efferent ductule
513:
511:Top expressed in
506:
479:body of pancreas
451:
449:Top expressed in
444:
423:
406:
396:
383:
372:
357:
350:
344:
333:
321:
305:
295:
282:
271:
256:
249:
243:
232:
218:
202:
196:
147:
140:
117:
84:
78:
57:
56:
51:
39:
21:
6316:
6315:
6311:
6310:
6309:
6307:
6306:
6305:
6256:
6255:
6254:
6249:
6228:
6157:
6134:
6129:
6099:
6094:
6093:
6072:
6026:
5998:
5961:
5923:Other globulins
5914:
5874:
5870:Immunoglobulins
5852:
5814:
5809:
5806:
5787:
5769:
5743:
5738:
5708:
5703:
5658:
5650:Alpha globulins
5632:
5627:
5597:
5592:
5571:
5533:
5489:
5478:Councilman body
5367:Viral infection
5361:
5327:Weil–Felix test
5313:Abelin reaction
5303:Wassermann test
5274:
5265:
5235:
5230:
5227:
5221:
5212:
5206:
5197:
5191:
5177:
5174:
5101:Wayback Machine
5053:
5048:
5002:
5001:
4997:
4951:
4950:
4946:
4900:
4899:
4895:
4851:
4850:
4846:
4810:
4809:
4805:
4759:
4758:
4754:
4710:
4709:
4705:
4688:
4637:
4636:
4632:
4627:
4623:
4577:
4576:
4569:
4546:(10): 891–899.
4533:
4532:
4528:
4492:
4491:
4487:
4449:
4448:
4444:
4408:
4407:
4403:
4378:10.1038/ng.3368
4366:Nature Genetics
4359:
4358:
4354:
4316:
4315:
4308:
4299:
4297:
4271:
4270:
4266:
4256:
4254:
4250:
4249:
4245:
4238:
4217:
4216:
4212:
4168:
4167:
4163:
4127:
4126:
4122:
4078:
4077:
4073:
4037:
4036:
4032:
4002:
4001:
3997:
3953:
3952:
3948:
3912:
3911:
3907:
3861:
3860:
3856:
3820:
3819:
3815:
3769:
3768:
3764:
3718:
3717:
3713:
3663:
3662:
3658:
3649:
3645:
3609:
3608:
3604:
3568:
3567:
3563:
3527:
3526:
3522:
3486:
3485:
3481:
3442:
3441:
3434:
3407:
3406:
3402:
3361:(8): e0161721.
3348:
3347:
3343:
3297:
3296:
3292:
3283:
3279:
3243:
3242:
3238:
3192:
3191:
3187:
3151:
3150:
3146:
3102:
3101:
3097:
3061:
3060:
3056:
3012:
3011:
3007:
3002:
2998:
2992:
2988:
2979:
2977:
2973:
2950:
2945:
2944:
2940:
2904:
2903:
2894:
2885:
2883:
2881:U.S. Pharmacist
2870:
2869:
2865:
2856:
2854:
2846:
2845:
2838:
2792:
2791:
2787:
2743:
2742:
2738:
2692:
2691:
2687:
2641:
2640:
2636:
2590:
2589:
2585:
2539:
2538:
2534:
2521:
2520:
2516:
2503:
2502:
2498:
2485:
2484:
2480:
2436:
2435:
2431:
2407:
2402:
2401:
2390:
2383:
2370:
2369:
2365:
2358:
2345:
2344:
2340:
2333:
2320:
2319:
2315:
2271:
2270:
2266:
2228:
2227:
2223:
2193:
2192:
2185:
2141:
2140:
2121:
2085:
2084:
2080:
2067:
2066:
2062:
2049:
2048:
2044:
2032:
2023:
2011:
2002:
1998:
1991:
1988:
1979:
1976:
1967:
1940:
1908:bone resorption
1882:
1862:
1837:
1810:Crohn's disease
1774:dermatomyositis
1763:
1701:
1620:
1520:
1515:
1499:
1466:
1437:
1418:
1384:
1376:innate immunity
1315:This so-called
1285:
1261:
1223:
1120:View/Edit Mouse
1115:View/Edit Human
1078:
1071:
1068:Location (UCSC)
1054:
1033:
1029:
1025:
1021:
995:
974:
970:
966:
962:
875:ENSG00000132693
768:
707:
686:
677:choline binding
662:protein binding
607:
597:
596:
569:
560:
555:
551:
547:
543:
539:
535:
531:
527:
523:
509:
498:
493:
489:
485:
481:
477:
473:
469:
465:
461:
447:
391:
378:
370:
360:
359:
358:
351:
331:
308:Gene location (
290:
277:
269:
259:
258:
257:
250:
228:
205:Gene location (
194:CRP - orthologs
156:
143:
136:
93:
71:
35:
28:
23:
22:
15:
12:
11:
5:
6314:
6312:
6304:
6303:
6298:
6293:
6288:
6283:
6278:
6273:
6268:
6258:
6257:
6251:
6250:
6248:
6247:
6242:
6236:
6234:
6230:
6229:
6227:
6226:
6221:
6216:
6211:
6206:
6201:
6196:
6191:
6186:
6181:
6176:
6171:
6165:
6163:
6162:Other positive
6159:
6158:
6156:
6155:
6150:
6144:
6142:
6136:
6135:
6130:
6128:
6127:
6120:
6113:
6105:
6096:
6095:
6092:
6091:
6082:
6081:
6078:
6077:
6074:
6073:
6071:
6070:
6065:
6060:
6055:
6050:
6040:
6034:
6032:
6028:
6027:
6025:
6024:
6019:
6014:
6008:
6006:
6000:
5999:
5997:
5996:
5991:
5986:
5980:
5978:
5969:
5963:
5962:
5960:
5959:
5954:
5949:
5944:
5939:
5938:
5937:
5926:
5924:
5920:
5919:
5916:
5915:
5913:
5912:
5907:
5905:Transcobalamin
5902:
5893:
5882:
5880:
5876:
5875:
5873:
5872:
5866:
5864:
5862:Gamma globulin
5858:
5857:
5854:
5853:
5851:
5850:
5845:
5840:
5835:
5830:
5825:
5819:
5817:
5811:
5810:
5808:
5807:
5801:
5795:
5793:
5781:
5779:Beta globulins
5775:
5774:
5771:
5770:
5768:
5767:
5756:
5748:
5746:
5740:
5739:
5737:
5736:
5731:
5724:
5716:
5714:
5705:
5704:
5702:
5701:
5691:
5681:
5666:
5664:
5652:
5643:
5634:
5633:
5628:
5626:
5625:
5618:
5611:
5603:
5594:
5593:
5591:
5590:
5585:
5579:
5577:
5573:
5572:
5570:
5569:
5564:
5559:
5554:
5549:
5543:
5541:
5535:
5534:
5532:
5531:
5530:
5529:
5524:
5512:
5511:
5510:
5499:
5497:
5491:
5490:
5488:
5487:
5482:
5481:
5480:
5468:
5463:
5462:
5461:
5449:
5448:
5447:
5442:
5437:
5427:
5426:
5425:
5413:
5412:
5411:
5401:
5400:
5399:
5389:
5388:
5387:
5382:
5371:
5369:
5363:
5362:
5360:
5359:
5358:
5357:
5345:
5344:
5343:
5331:
5330:
5329:
5317:
5316:
5315:
5310:
5305:
5300:
5295:
5284:
5282:
5276:
5275:
5266:
5264:
5263:
5256:
5249:
5241:
5232:
5231:
5229:
5228:
5222:
5215:
5213:
5207:
5200:
5198:
5192:
5185:
5182:
5179:
5178:
5175:
5173:
5172:
5165:
5158:
5150:
5144:
5143:
5122:
5103:
5091:
5085:
5075:
5065:
5052:
5051:External links
5049:
5047:
5046:
5015:(3): e11–e12.
4995:
4944:
4893:
4844:
4803:
4752:
4723:(1): 219–229.
4703:
4630:
4621:
4567:
4526:
4505:(5): 585–590.
4485:
4458:(4): 155–170.
4442:
4421:(4): 221–233.
4401:
4352:
4325:(5): 661–665.
4306:
4284:(9): 409–416.
4264:
4243:
4237:978-1437727883
4236:
4210:
4161:
4120:
4091:(4): 680–683.
4071:
4030:
3995:
3946:
3905:
3874:(4): 261–265.
3854:
3813:
3762:
3711:
3656:
3643:
3602:
3581:(3): 562–566.
3561:
3540:(3): 872–878.
3520:
3499:(3): 327–334.
3479:
3452:(6): 467–472.
3432:
3400:
3341:
3310:(2): 115–117.
3290:
3277:
3256:(3): 461–463.
3236:
3185:
3144:
3115:(1): 166–175.
3095:
3054:
3005:
2996:
2986:
2961:(3): 477–483.
2938:
2917:(3): 499–511.
2892:
2877:Cardiovascular
2863:
2836:
2785:
2756:(3): 191–199.
2736:
2685:
2634:
2583:
2532:
2514:
2496:
2478:
2429:
2418:(6): 317–321.
2388:
2381:
2363:
2356:
2338:
2331:
2313:
2284:(4): 561–571.
2264:
2221:
2183:
2119:
2098:(2): 169–177.
2078:
2060:
2042:
2021:
1999:
1997:
1994:
1993:
1992:
1989:
1982:
1980:
1977:
1970:
1966:
1963:
1939:
1936:
1881:
1878:
1861:
1858:
1836:
1833:
1790:kidney failure
1762:
1759:
1739:
1738:
1735:
1732:
1700:
1697:
1619:
1616:
1592:co-morbidities
1561:
1560:
1557:
1554:
1519:
1518:Diagnostic use
1516:
1514:
1511:
1498:
1495:
1483:skin infection
1465:
1462:
1436:
1433:
1417:
1414:
1411:
1410:
1407:
1403:
1402:
1395:
1391:
1390:
1383:
1380:
1363:by the liver.
1289:phosphocholine
1284:
1281:
1269:signal peptide
1260:
1257:
1249:polysaccharide
1225:Discovered by
1222:
1219:
1127:
1126:
1123:
1122:
1117:
1107:
1106:
1100:
1099:
1096:
1095:
1093:
1091:
1084:
1083:
1076:
1069:
1065:
1064:
1061:
1060:
1050:
1049:
1043:
1040:
1039:
1017:
1016:
1010:
1006:
1005:
1002:
1001:
991:
990:
984:
981:
980:
958:
957:
951:
947:
946:
943:
942:
934:
933:
927:
924:
923:
915:
914:
908:
902:
901:
898:
897:
889:
888:
882:
879:
878:
870:
869:
863:
857:
856:
853:
852:
844:
843:
837:
834:
833:
825:
824:
818:
812:
811:
806:
801:
797:
796:
786:
785:
782:
781:
770:
769:
767:
766:
761:
756:
751:
746:
741:
736:
731:
726:
721:
715:
713:
709:
708:
706:
705:
700:
694:
692:
688:
687:
685:
684:
679:
674:
669:
664:
659:
654:
652:virion binding
649:
644:
638:
636:
632:
631:
621:
620:
617:
616:
613:
612:
604:
603:
585:
579:
578:
575:
574:
566:
565:
562:
561:
559:
558:
554:
550:
546:
542:
538:
534:
530:
526:
522:
518:
515:
514:
503:
500:
499:
497:
496:
492:
488:
484:
480:
476:
472:
468:
464:
460:
456:
453:
452:
440:
439:
431:
420:
414:
413:
410:RNA expression
402:
401:
398:
397:
389:
385:
384:
376:
373:
368:
362:
361:
352:
345:
339:
335:
334:
329:
323:
322:
314:
313:
301:
300:
297:
296:
288:
284:
283:
275:
272:
267:
261:
260:
251:
244:
238:
234:
233:
226:
220:
219:
211:
210:
198:
197:
154:
150:
149:
141:
133:
132:
128:
127:
124:
123:
120:
119:
89:
88:
80:
79:
68:
62:
61:
53:
52:
44:
43:
26:
24:
14:
13:
10:
9:
6:
4:
3:
2:
6313:
6302:
6299:
6297:
6294:
6292:
6289:
6287:
6284:
6282:
6279:
6277:
6274:
6272:
6269:
6267:
6264:
6263:
6261:
6246:
6243:
6241:
6240:Serum albumin
6238:
6237:
6235:
6231:
6225:
6222:
6220:
6217:
6215:
6212:
6210:
6207:
6205:
6202:
6200:
6197:
6195:
6192:
6190:
6189:Ceruloplasmin
6187:
6185:
6182:
6180:
6177:
6175:
6172:
6170:
6167:
6166:
6164:
6160:
6154:
6151:
6149:
6146:
6145:
6143:
6141:
6137:
6133:
6126:
6121:
6119:
6114:
6112:
6107:
6106:
6103:
6090:
6087:
6084:
6083:
6079:
6069:
6066:
6064:
6061:
6059:
6056:
6054:
6051:
6048:
6044:
6041:
6039:
6036:
6035:
6033:
6029:
6023:
6020:
6018:
6015:
6013:
6010:
6009:
6007:
6005:
6004:Serum albumin
6001:
5995:
5992:
5990:
5987:
5985:
5982:
5981:
5979:
5977:
5973:
5970:
5968:
5964:
5958:
5955:
5953:
5950:
5948:
5945:
5943:
5942:Thyroglobulin
5940:
5936:
5933:
5932:
5931:
5928:
5927:
5925:
5921:
5911:
5908:
5906:
5903:
5901:
5900:Microglobulin
5897:
5896:Macroglobulin
5894:
5891:
5887:
5884:
5883:
5881:
5877:
5871:
5868:
5867:
5865:
5863:
5859:
5849:
5846:
5844:
5841:
5839:
5836:
5834:
5831:
5829:
5826:
5824:
5821:
5820:
5818:
5812:
5805:
5802:
5800:
5797:
5796:
5794:
5790:
5785:
5782:
5780:
5776:
5765:
5761:
5757:
5754:
5750:
5749:
5747:
5741:
5735:
5732:
5729:
5728:Ceruloplasmin
5725:
5722:
5718:
5717:
5715:
5711:
5706:
5699:
5695:
5692:
5689:
5685:
5682:
5679:
5675:
5671:
5668:
5667:
5665:
5661:
5656:
5653:
5651:
5647:
5644:
5642:
5639:
5635:
5631:
5624:
5619:
5617:
5612:
5610:
5605:
5604:
5601:
5589:
5588:Procalcitonin
5586:
5584:
5581:
5580:
5578:
5574:
5568:
5565:
5563:
5560:
5558:
5555:
5553:
5550:
5548:
5547:Blood culture
5545:
5544:
5542:
5540:
5536:
5528:
5525:
5523:
5520:
5519:
5518:
5517:
5513:
5509:
5506:
5505:
5504:
5503:toxoplasmosis
5501:
5500:
5498:
5496:
5492:
5486:
5483:
5479:
5476:
5475:
5474:
5473:
5469:
5467:
5466:Cowdry bodies
5464:
5460:
5457:
5456:
5455:
5454:
5450:
5446:
5443:
5441:
5438:
5436:
5435:Downie bodies
5433:
5432:
5431:
5428:
5424:
5421:
5420:
5419:
5418:
5414:
5410:
5407:
5406:
5405:
5402:
5398:
5395:
5394:
5393:
5390:
5386:
5383:
5381:
5378:
5377:
5376:
5373:
5372:
5370:
5368:
5364:
5356:
5353:
5352:
5351:
5350:
5349:Streptococcus
5346:
5342:
5339:
5338:
5337:
5336:
5332:
5328:
5325:
5324:
5323:
5322:
5318:
5314:
5311:
5309:
5306:
5304:
5301:
5299:
5296:
5294:
5291:
5290:
5289:
5286:
5285:
5283:
5281:
5277:
5273:
5269:
5262:
5257:
5255:
5250:
5248:
5243:
5242:
5239:
5225:
5219:
5214:
5210:
5204:
5199:
5195:
5189:
5184:
5180:
5171:
5166:
5164:
5159:
5157:
5152:
5151:
5148:
5141:
5137:
5136:
5131:
5127:
5123:
5120:
5116:
5115:
5110:
5109:
5104:
5102:
5098:
5095:
5092:
5089:
5086:
5083:
5079:
5076:
5073:
5069:
5066:
5064:
5060:
5059:
5055:
5054:
5050:
5042:
5038:
5033:
5028:
5023:
5018:
5014:
5010:
5006:
4999:
4996:
4991:
4987:
4982:
4977:
4972:
4967:
4963:
4959:
4955:
4948:
4945:
4940:
4936:
4931:
4926:
4921:
4916:
4912:
4908:
4904:
4897:
4894:
4889:
4885:
4880:
4875:
4871:
4867:
4863:
4859:
4855:
4848:
4845:
4840:
4836:
4831:
4826:
4822:
4818:
4814:
4807:
4804:
4799:
4795:
4790:
4785:
4780:
4775:
4771:
4767:
4763:
4756:
4753:
4748:
4744:
4740:
4736:
4731:
4726:
4722:
4718:
4714:
4707:
4704:
4699:
4693:
4685:
4681:
4677:
4673:
4668:
4663:
4658:
4653:
4649:
4645:
4641:
4634:
4631:
4625:
4622:
4617:
4613:
4608:
4603:
4598:
4593:
4589:
4585:
4581:
4574:
4572:
4568:
4563:
4559:
4554:
4549:
4545:
4541:
4537:
4530:
4527:
4522:
4518:
4513:
4508:
4504:
4500:
4496:
4489:
4486:
4481:
4477:
4473:
4469:
4465:
4461:
4457:
4453:
4446:
4443:
4438:
4434:
4429:
4424:
4420:
4416:
4412:
4405:
4402:
4397:
4393:
4388:
4383:
4379:
4375:
4371:
4367:
4363:
4356:
4353:
4348:
4344:
4340:
4336:
4332:
4328:
4324:
4320:
4313:
4311:
4307:
4296:on 2012-01-10
4295:
4291:
4287:
4283:
4279:
4275:
4268:
4265:
4253:
4247:
4244:
4239:
4233:
4229:
4224:
4223:
4214:
4211:
4206:
4202:
4197:
4192:
4188:
4184:
4180:
4176:
4172:
4165:
4162:
4157:
4153:
4148:
4143:
4139:
4135:
4131:
4124:
4121:
4116:
4112:
4107:
4102:
4098:
4094:
4090:
4086:
4082:
4075:
4072:
4067:
4063:
4058:
4053:
4049:
4045:
4041:
4034:
4031:
4026:
4022:
4018:
4014:
4010:
4006:
3999:
3996:
3991:
3987:
3982:
3977:
3973:
3969:
3965:
3961:
3957:
3950:
3947:
3942:
3938:
3933:
3928:
3924:
3920:
3916:
3909:
3906:
3901:
3897:
3892:
3887:
3882:
3877:
3873:
3869:
3865:
3858:
3855:
3850:
3846:
3841:
3836:
3832:
3828:
3824:
3817:
3814:
3809:
3805:
3800:
3795:
3790:
3785:
3781:
3777:
3773:
3766:
3763:
3758:
3754:
3749:
3744:
3739:
3734:
3730:
3726:
3722:
3715:
3712:
3707:
3703:
3699:
3695:
3691:
3687:
3683:
3679:
3675:
3671:
3667:
3660:
3657:
3653:
3647:
3644:
3639:
3635:
3630:
3625:
3621:
3617:
3613:
3606:
3603:
3598:
3594:
3589:
3584:
3580:
3576:
3572:
3565:
3562:
3557:
3553:
3548:
3543:
3539:
3535:
3531:
3524:
3521:
3516:
3512:
3507:
3502:
3498:
3494:
3490:
3483:
3480:
3475:
3471:
3467:
3463:
3459:
3455:
3451:
3447:
3439:
3437:
3433:
3428:
3424:
3420:
3416:
3412:
3404:
3401:
3396:
3392:
3387:
3382:
3377:
3372:
3368:
3364:
3360:
3356:
3352:
3345:
3342:
3337:
3333:
3328:
3323:
3318:
3313:
3309:
3305:
3301:
3294:
3291:
3287:
3281:
3278:
3273:
3269:
3264:
3259:
3255:
3251:
3247:
3240:
3237:
3232:
3228:
3223:
3218:
3213:
3208:
3204:
3200:
3196:
3189:
3186:
3181:
3177:
3172:
3167:
3163:
3159:
3155:
3148:
3145:
3140:
3136:
3131:
3126:
3122:
3118:
3114:
3110:
3109:Diabetes Care
3106:
3099:
3096:
3091:
3087:
3082:
3077:
3073:
3069:
3065:
3058:
3055:
3050:
3046:
3041:
3036:
3032:
3028:
3024:
3020:
3016:
3009:
3006:
3000:
2997:
2990:
2987:
2976:on 2021-12-09
2972:
2968:
2964:
2960:
2956:
2949:
2942:
2939:
2934:
2930:
2925:
2920:
2916:
2912:
2908:
2901:
2899:
2897:
2893:
2882:
2878:
2874:
2867:
2864:
2853:
2849:
2843:
2841:
2837:
2832:
2828:
2823:
2818:
2813:
2808:
2804:
2800:
2796:
2789:
2786:
2781:
2777:
2772:
2767:
2763:
2759:
2755:
2752:(in German).
2751:
2747:
2740:
2737:
2732:
2728:
2723:
2718:
2713:
2708:
2704:
2700:
2696:
2689:
2686:
2681:
2677:
2672:
2667:
2662:
2657:
2653:
2649:
2645:
2638:
2635:
2630:
2626:
2621:
2616:
2611:
2606:
2602:
2598:
2594:
2587:
2584:
2579:
2575:
2570:
2565:
2560:
2555:
2551:
2547:
2543:
2536:
2533:
2528:
2524:
2518:
2515:
2510:
2506:
2500:
2497:
2492:
2488:
2482:
2479:
2474:
2470:
2465:
2460:
2456:
2452:
2448:
2444:
2440:
2433:
2430:
2425:
2421:
2417:
2413:
2406:
2399:
2397:
2395:
2393:
2389:
2384:
2378:
2374:
2367:
2364:
2359:
2353:
2349:
2342:
2339:
2334:
2328:
2324:
2317:
2314:
2309:
2305:
2300:
2295:
2291:
2287:
2283:
2279:
2275:
2268:
2265:
2260:
2256:
2252:
2248:
2244:
2240:
2236:
2232:
2225:
2222:
2217:
2213:
2209:
2205:
2201:
2197:
2190:
2188:
2184:
2179:
2175:
2170:
2165:
2161:
2157:
2153:
2149:
2145:
2138:
2136:
2134:
2132:
2130:
2128:
2126:
2124:
2120:
2115:
2111:
2106:
2101:
2097:
2093:
2089:
2082:
2079:
2074:
2070:
2064:
2061:
2056:
2052:
2046:
2043:
2039:
2035:
2030:
2028:
2026:
2022:
2018:
2014:
2009:
2007:
2005:
2001:
1995:
1986:
1981:
1974:
1969:
1964:
1962:
1960:
1956:
1952:
1948:
1945:
1937:
1935:
1932:
1928:
1924:
1919:
1917:
1913:
1909:
1905:
1901:
1896:
1891:
1887:
1879:
1877:
1875:
1871:
1867:
1859:
1857:
1855:
1850:
1846:
1841:
1834:
1832:
1830:
1826:
1822:
1817:
1815:
1811:
1807:
1803:
1800:, and severe
1799:
1795:
1791:
1787:
1783:
1780:(SLE) unless
1779:
1775:
1771:
1767:
1760:
1758:
1756:
1752:
1751:triglycerides
1748:
1744:
1736:
1733:
1730:
1729:
1728:
1726:
1722:
1717:
1714:
1710:
1707:invasion and
1706:
1698:
1696:
1694:
1693:atherogenesis
1689:
1687:
1683:
1682:meta-analysis
1678:
1675:
1674:JUPITER trial
1671:
1666:
1664:
1661:
1657:
1653:
1649:
1646:
1641:
1637:
1633:
1629:
1625:
1617:
1615:
1613:
1608:
1605:
1601:
1597:
1593:
1588:
1586:
1582:
1578:
1574:
1570:
1566:
1558:
1555:
1552:
1551:
1550:
1548:
1544:
1540:
1536:
1531:
1529:
1525:
1524:liver failure
1517:
1512:
1510:
1508:
1504:
1496:
1494:
1492:
1488:
1484:
1480:
1476:
1472:
1463:
1461:
1459:
1458:interleukin 6
1455:
1451:
1447:
1443:
1434:
1432:
1429:
1424:
1415:
1408:
1404:
1400:
1397:Detection of
1396:
1392:
1387:
1381:
1379:
1377:
1373:
1369:
1364:
1362:
1358:
1354:
1350:
1346:
1342:
1338:
1334:
1330:
1326:
1322:
1321:interleukin-6
1318:
1313:
1310:
1306:
1302:
1298:
1294:
1290:
1282:
1280:
1278:
1274:
1270:
1266:
1258:
1256:
1254:
1250:
1247:
1242:
1240:
1236:
1232:
1228:
1220:
1218:
1216:
1212:
1209:(insulin) or
1208:
1204:
1200:
1196:
1192:
1187:
1185:
1181:
1177:
1173:
1169:
1166:secretion by
1165:
1164:interleukin-6
1161:
1157:
1153:
1149:
1145:
1141:
1137:
1133:
1121:
1116:
1112:
1108:
1105:
1101:
1094:
1092:
1089:
1085:
1081:
1077:
1074:
1070:
1066:
1059:
1057:
1051:
1047:
1044:
1038:
1036:
1032:
1028:
1024:
1018:
1014:
1011:
1007:
1000:
998:
992:
988:
985:
979:
977:
973:
969:
965:
959:
955:
952:
950:RefSeq (mRNA)
948:
941:
940:
935:
931:
928:
922:
921:
916:
912:
909:
907:
903:
896:
895:
890:
886:
883:
877:
876:
871:
867:
864:
862:
858:
851:
850:
845:
841:
838:
832:
831:
826:
822:
819:
817:
813:
810:
807:
805:
802:
798:
795:
791:
787:
780:
776:
771:
765:
762:
760:
757:
755:
752:
750:
747:
745:
742:
740:
737:
735:
732:
730:
727:
725:
722:
720:
717:
716:
714:
711:
710:
704:
701:
699:
696:
695:
693:
690:
689:
683:
680:
678:
675:
673:
670:
668:
665:
663:
660:
658:
655:
653:
650:
648:
645:
643:
640:
639:
637:
634:
633:
630:
629:Gene ontology
626:
622:
610:
605:
601:
594:
589:
586:
584:
580:
572:
567:
556:
552:
548:
544:
540:
536:
532:
528:
524:
520:
519:
516:
512:
507:
504:
494:
490:
486:
482:
478:
474:
470:
466:
462:
458:
457:
454:
450:
445:
442:
441:
438:
436:
432:
430:
429:
425:
424:
421:
419:
415:
411:
407:
403:
395:
390:
386:
382:
377:
367:
363:
356:
349:
343:
336:
328:
324:
320:
315:
311:
306:
302:
294:
289:
285:
281:
276:
266:
262:
255:
248:
242:
235:
231:
225:
221:
217:
212:
208:
203:
199:
195:
191:
187:
183:
179:
175:
171:
167:
163:
159:
151:
146:
139:
134:
129:
118:
116:
112:
108:
104:
100:
96:
90:
85:
82:
81:
77:
74:
67:
63:
58:
54:
50:
45:
40:
37:
33:
19:
6183:
6085:
6037:
5694:Antithrombin
5582:
5514:
5472:yellow fever
5470:
5459:Negri bodies
5451:
5415:
5404:Dengue fever
5347:
5335:Helicobacter
5333:
5319:
5223:
5208:
5193:
5133:
5113:
5107:
5056:
5012:
5008:
4998:
4961:
4957:
4947:
4910:
4906:
4896:
4864:(1): 39–46.
4861:
4857:
4847:
4820:
4816:
4806:
4769:
4765:
4755:
4720:
4716:
4706:
4692:cite journal
4647:
4643:
4633:
4624:
4587:
4583:
4543:
4539:
4529:
4502:
4498:
4488:
4455:
4451:
4445:
4418:
4414:
4404:
4369:
4365:
4355:
4322:
4318:
4298:. Retrieved
4294:the original
4281:
4277:
4267:
4255:. Retrieved
4246:
4221:
4213:
4178:
4174:
4164:
4140:(1): 35–42.
4137:
4133:
4123:
4088:
4084:
4074:
4047:
4043:
4033:
4008:
4004:
3998:
3963:
3959:
3949:
3922:
3918:
3908:
3871:
3867:
3857:
3830:
3826:
3816:
3779:
3775:
3765:
3731:(10): 2711.
3728:
3725:Biomedicines
3724:
3714:
3673:
3669:
3659:
3646:
3619:
3615:
3605:
3578:
3574:
3564:
3537:
3533:
3523:
3496:
3492:
3482:
3449:
3445:
3410:
3403:
3358:
3354:
3344:
3307:
3303:
3293:
3285:
3280:
3253:
3249:
3239:
3202:
3198:
3188:
3161:
3157:
3147:
3112:
3108:
3098:
3071:
3067:
3057:
3022:
3018:
3008:
2999:
2989:
2978:. Retrieved
2971:the original
2958:
2954:
2941:
2914:
2910:
2884:. Retrieved
2876:
2866:
2855:. Retrieved
2851:
2802:
2798:
2788:
2753:
2749:
2739:
2705:(13): 3610.
2702:
2698:
2688:
2651:
2648:Biomedicines
2647:
2637:
2600:
2596:
2586:
2552:(24): 5837.
2549:
2545:
2535:
2526:
2517:
2508:
2499:
2481:
2446:
2442:
2432:
2415:
2411:
2372:
2366:
2347:
2341:
2322:
2316:
2281:
2277:
2267:
2234:
2230:
2224:
2199:
2195:
2151:
2147:
2095:
2091:
2081:
2072:
2063:
2054:
2045:
1959:Wuhan, China
1941:
1920:
1883:
1863:
1849:colon cancer
1842:
1838:
1820:
1818:
1770:polymyositis
1764:
1740:
1718:
1709:inflammation
1702:
1690:
1679:
1667:
1628:hypertension
1621:
1609:
1604:malnutrition
1589:
1573:inflammation
1571:women, mild
1562:
1547:nephelometry
1532:
1521:
1500:
1467:
1438:
1428:hemodialysis
1419:
1406:Test of
1399:inflammation
1382:Serum levels
1365:
1343:infections;
1314:
1301:phagocytosis
1299:, promoting
1286:
1262:
1253:pneumococcus
1243:
1224:
1188:
1152:inflammation
1144:blood plasma
1135:
1131:
1130:
1053:
1035:NP_001369632
1031:NP_001315987
1027:NP_001315986
1020:
994:
976:NM_001382703
972:NM_001329058
968:NM_001329057
961:
937:
918:
892:
873:
847:
828:
808:
803:
749:opsonization
537:vas deferens
433:
426:
392:172,660,598
379:172,525,622
291:159,714,589
278:159,712,289
153:External IDs
92:
36:
6281:Blood tests
6245:Transferrin
6224:Orosomucoid
6209:Haptoglobin
6053:Parvalbumin
6043:Lactalbumin
5935:Lactoferrin
5886:Fibronectin
5843:Plasminogen
5823:Angiostatin
5804:Transferrin
5764:Haptoglobin
5753:Orosomucoid
5721:Transcortin
5562:Parasitemia
5485:Tzanck test
5375:HIV testing
5268:Blood tests
5176:PDB gallery
3919:Circulation
3782:(7): 1771.
3444:syndrome".
2911:Circulation
2654:(8): 2279.
2505:"#CAA39671"
2237:(1): 1–13.
1766:Scleroderma
1743:cholesterol
1442:subclinical
1327:as well as
1325:macrophages
1277:translation
1195:macrophages
1168:macrophages
1154:. It is an
533:human fetus
467:gallbladder
131:Identifiers
6271:Biomarkers
6260:Categories
6022:Prealbumin
5984:Conalbumin
5321:Rickettsia
4772:(5): 475.
4650:(37): 37.
4590:: 621736.
4300:2013-02-10
3205:: 622326.
2980:2020-12-28
2886:2020-12-28
2857:2019-12-23
2603:: 630430.
2040:, May 2017
2019:, May 2017
1996:References
1904:osteoclast
1843:In a 2004
1656:myocardial
1652:complement
1491:bronchitis
1475:TGF beta 1
1368:complement
1361:fibrinogen
1353:malignancy
1347:and other
1329:adipocytes
1265:pentraxins
1199:adipocytes
553:epididymis
491:ectocervix
437:(ortholog)
174:HomoloGene
6219:Hemopexin
5989:Ovalbumin
5976:Egg white
5848:Properdin
5828:Hemopexin
5758:alpha-2 (
5751:alpha-1 (
5726:alpha-2 (
5719:alpha-1 (
5641:globulins
4823:: 31–36.
4747:230108148
2994:36136302.
2092:Structure
1944:avian flu
1931:haplotype
1916:monocytes
1786:synovitis
1782:serositis
1723:and U.S.
1640:trans fat
1357:cytokines
1345:rheumatic
1333:bacterial
1309:apoptotic
1246:cell wall
1211:protein C
1207:C-peptide
1203:pentraxin
1142:found in
1056:NP_031794
1023:NP_000558
997:NM_007768
964:NM_000567
794:Orthologs
182:GeneCards
6233:Negative
6199:Ferritin
6086:see also
5967:Albumins
5838:Factor H
5567:Algaemia
5557:Fungemia
5288:syphilis
5097:Archived
5041:32061335
4990:32007143
4939:32031570
4888:30288556
4839:26809124
4798:25359432
4739:33385862
4676:26832367
4616:23533751
4562:12621133
4521:14762037
4480:40322991
4472:22035340
4437:16603636
4396:26366554
4347:11984165
4339:15472532
4290:16239491
4252:"hs-CRP"
4205:22945505
4156:16818927
4115:19297430
4066:18971492
4025:22520533
3990:21277016
3941:11306519
3900:22025854
3849:18997196
3808:35407379
3757:37893085
3748:10603830
3698:16642000
3638:15070788
3597:15735094
3556:17327459
3534:Diabetes
3515:11466099
3466:23689052
3427:38886920
3395:27559728
3355:PLOS ONE
3336:22787338
3231:33584722
3180:19950271
3139:23264288
3090:16055753
2967:22569431
2933:12551878
2831:29706967
2780:35333926
2731:35806892
2680:37626775
2671:10452736
2629:33679775
2578:34945133
2424:29094869
2308:19869788
2259:20300531
2251:17828584
2216:15653761
2178:12813013
2114:10368284
2036:–
2015:–
1955:COVID-19
1927:genotype
1713:specific
1663:infarcts
1660:cerebral
1648:necrosis
1645:ischemic
1636:quartile
1624:diabetes
1594:such as
1569:pregnant
1487:cystitis
1401:in body.
1305:necrotic
1293:bacteria
1283:Function
1146:, whose
1104:Wikidata
773:Sources:
475:testicle
6140:Amyloid
5910:Edestin
5684:alpha-2
5670:alpha-1
5660:serpins
5576:General
5552:Viremia
5516:malaria
5417:measles
5140:PDBe-KB
5130:UniProt
5032:7159020
4981:7135076
4930:7042881
4879:6314979
4789:4247621
4684:1926353
4667:4736641
4607:3600315
4387:4627508
4257:June 3,
4196:3613132
4106:2666362
3981:3042687
3891:3198521
3799:8999816
3706:4324584
3678:Bibcode
3474:5173681
3386:4999186
3363:Bibcode
3327:3391832
3272:2493344
3222:7876312
3130:3526249
3049:8473487
2822:5908901
2805:: 754.
2771:8951661
2722:9267697
2620:7934421
2569:8708507
2473:7299351
2464:2186532
2299:2131884
2038:Ensembl
2017:Ensembl
1755:Smoking
1670:statins
1596:malaria
1394:Purpose
1275:before
1227:Tillett
1172:T cells
1160:hepatic
906:UniProt
861:Ensembl
800:Species
779:QuickGO
412:pattern
138:Aliases
6204:Fibrin
5994:Avidin
5888:(fFN:
5815:other:
5744:other:
5453:rabies
5135:P02741
5105:Human
5084:(MeSH)
5039:
5029:
4988:
4978:
4958:Lancet
4937:
4927:
4886:
4876:
4837:
4796:
4786:
4745:
4737:
4682:
4674:
4664:
4614:
4604:
4560:
4519:
4478:
4470:
4435:
4394:
4384:
4345:
4337:
4288:
4234:
4203:
4193:
4154:
4113:
4103:
4064:
4023:
3988:
3978:
3960:Lancet
3939:
3898:
3888:
3847:
3806:
3796:
3755:
3745:
3704:
3696:
3670:Nature
3636:
3595:
3554:
3513:
3472:
3464:
3425:
3393:
3383:
3334:
3324:
3270:
3229:
3219:
3178:
3137:
3127:
3088:
3047:
3040:288106
3037:
2965:
2931:
2829:
2819:
2778:
2768:
2729:
2719:
2678:
2668:
2627:
2617:
2576:
2566:
2471:
2461:
2422:
2379:
2354:
2329:
2306:
2296:
2257:
2249:
2214:
2176:
2169:161431
2166:
2112:
1835:Cancer
1794:stroke
1772:, and
1477:, and
1435:Normal
1341:fungal
1231:cancer
1090:search
1088:PubMed
939:P14847
920:P02741
816:Entrez
583:BioGPS
545:thymus
270:1q23.2
178:128039
162:123260
6058:Ricin
6031:Other
5879:Other
5638:Serum
5385:mChip
4743:S2CID
4680:S2CID
4476:S2CID
4343:S2CID
3702:S2CID
3470:S2CID
2974:(PDF)
2951:(PDF)
2408:(PDF)
2255:S2CID
1912:RANKL
1895:YWHAH
1890:EULAR
1829:lipid
1747:LDL-C
1680:In a
1650:in a
1585:burns
1565:aging
1535:ELISA
1489:, or
1339:, or
1337:viral
1191:liver
849:12944
809:Mouse
804:Human
775:Amigo
471:gonad
435:Mouse
428:Human
375:Start
310:Mouse
274:Start
207:Human
170:88512
5270:for
5224:1lj7
5209:1gnh
5194:1b09
5128:for
5037:PMID
4986:PMID
4935:PMID
4907:JAMA
4884:PMID
4835:PMID
4794:PMID
4735:PMID
4698:link
4672:PMID
4612:PMID
4588:2013
4558:PMID
4517:PMID
4499:JAMA
4468:PMID
4433:PMID
4392:PMID
4335:PMID
4286:PMID
4259:2013
4232:ISBN
4201:PMID
4152:PMID
4111:PMID
4062:PMID
4021:PMID
3986:PMID
3937:PMID
3896:PMID
3845:PMID
3804:PMID
3753:PMID
3694:PMID
3634:PMID
3593:PMID
3552:PMID
3511:PMID
3493:JAMA
3462:PMID
3423:PMID
3391:PMID
3332:PMID
3268:PMID
3227:PMID
3176:PMID
3135:PMID
3086:PMID
3045:PMID
2963:PMID
2929:PMID
2827:PMID
2776:PMID
2727:PMID
2676:PMID
2625:PMID
2574:PMID
2469:PMID
2420:PMID
2377:ISBN
2352:ISBN
2327:ISBN
2304:PMID
2247:PMID
2212:PMID
2174:PMID
2110:PMID
1951:H1N1
1947:H7N9
1929:and
1821:APOE
1812:and
1719:The
1658:and
1630:and
1602:and
1583:and
1575:and
1537:and
1505:and
1307:and
1182:via
1170:and
830:1401
418:Bgee
366:Band
327:Chr.
265:Band
224:Chr.
158:OMIM
115:3PVO
111:3PVN
107:3L2Y
103:1LJ7
99:1GNH
95:1B09
76:RCSB
73:PDBe
6153:SAA
6148:SAP
5126:PDB
5114:CRP
5108:CRP
5027:PMC
5017:doi
4976:PMC
4966:doi
4962:395
4925:PMC
4915:doi
4911:323
4874:PMC
4866:doi
4825:doi
4784:PMC
4774:doi
4725:doi
4662:PMC
4652:doi
4602:PMC
4592:doi
4548:doi
4544:348
4507:doi
4503:291
4460:doi
4423:doi
4382:PMC
4374:doi
4327:doi
4282:105
4191:PMC
4183:doi
4179:172
4142:doi
4138:145
4101:PMC
4093:doi
4089:139
4052:doi
4048:359
4013:doi
4009:163
3976:PMC
3968:doi
3964:377
3927:doi
3923:103
3886:PMC
3876:doi
3835:doi
3831:359
3794:PMC
3784:doi
3743:PMC
3733:doi
3686:doi
3674:440
3624:doi
3620:350
3583:doi
3579:135
3542:doi
3501:doi
3497:286
3454:doi
3450:346
3415:doi
3381:PMC
3371:doi
3322:PMC
3312:doi
3258:doi
3217:PMC
3207:doi
3166:doi
3125:PMC
3117:doi
3076:doi
3035:PMC
3027:doi
2919:doi
2915:107
2817:PMC
2807:doi
2766:PMC
2758:doi
2754:117
2717:PMC
2707:doi
2666:PMC
2656:doi
2615:PMC
2605:doi
2564:PMC
2554:doi
2459:PMC
2451:doi
2447:154
2416:115
2412:WMJ
2294:PMC
2286:doi
2239:doi
2204:doi
2200:288
2164:PMC
2156:doi
2152:111
2100:doi
1957:in
1784:or
1638:of
1600:HIV
1452:of
1184:C1q
1158:of
1136:CRP
388:End
287:End
190:OMA
186:CRP
166:MGI
145:CRP
66:PDB
42:CRP
6262::
6194:C3
5762:,
5676:,
5132::
5061::
5035:.
5025:.
5011:.
5007:.
4984:.
4974:.
4960:.
4956:.
4933:.
4923:.
4909:.
4905:.
4882:.
4872:.
4862:68
4860:.
4856:.
4833:.
4821:44
4819:.
4815:.
4792:.
4782:.
4770:16
4768:.
4764:.
4741:.
4733:.
4721:51
4719:.
4715:.
4694:}}
4690:{{
4678:.
4670:.
4648:18
4646:.
4642:.
4610:.
4600:.
4586:.
4582:.
4570:^
4556:.
4542:.
4538:.
4515:.
4501:.
4497:.
4474:.
4466:.
4456:48
4454:.
4431:.
4417:.
4413:.
4390:.
4380:.
4370:47
4368:.
4364:.
4341:.
4333:.
4323:10
4321:.
4309:^
4280:.
4276:.
4230:.
4228:54
4199:.
4189:.
4177:.
4173:.
4150:.
4136:.
4132:.
4109:.
4099:.
4087:.
4083:.
4060:.
4046:.
4042:.
4019:.
4007:.
3984:.
3974:.
3962:.
3958:.
3935:.
3921:.
3917:.
3894:.
3884:.
3870:.
3866:.
3843:.
3829:.
3825:.
3802:.
3792:.
3780:11
3778:.
3774:.
3751:.
3741:.
3729:11
3727:.
3723:.
3700:.
3692:.
3684:.
3672:.
3668:.
3632:.
3618:.
3614:.
3591:.
3577:.
3573:.
3550:.
3538:56
3536:.
3532:.
3509:.
3495:.
3491:.
3468:.
3460:.
3448:.
3435:^
3421:.
3413:.
3389:.
3379:.
3369:.
3359:11
3357:.
3353:.
3330:.
3320:.
3306:.
3302:.
3266:.
3254:35
3252:.
3248:.
3225:.
3215:.
3203:11
3201:.
3197:.
3174:.
3162:60
3160:.
3156:.
3133:.
3123:.
3113:36
3111:.
3107:.
3084:.
3072:25
3070:.
3066:.
3043:.
3033:.
3023:91
3021:.
3017:.
2959:23
2957:.
2953:.
2927:.
2913:.
2909:.
2895:^
2879:.
2875:.
2850:.
2839:^
2825:.
2815:.
2801:.
2797:.
2774:.
2764:.
2748:.
2725:.
2715:.
2703:11
2701:.
2697:.
2674:.
2664:.
2652:11
2650:.
2646:.
2623:.
2613:.
2601:12
2599:.
2595:.
2572:.
2562:.
2550:10
2548:.
2544:.
2525:.
2507:.
2489:.
2467:.
2457:.
2445:.
2441:.
2414:.
2410:.
2391:^
2302:.
2292:.
2282:52
2280:.
2276:.
2253:.
2245:.
2235:28
2233:.
2210:.
2198:.
2186:^
2172:.
2162:.
2150:.
2146:.
2122:^
2108:.
2094:.
2090:.
2071:.
2053:.
2024:^
2003:^
1918:.
1816:.
1796:,
1768:,
1749:,
1745:,
1626:,
1598:,
1509:.
1485:,
1456:,
1351:;
1335:,
1255:.
1186:.
777:/
394:bp
381:bp
293:bp
280:bp
188:;
184::
180:;
176::
172:;
168::
164:;
160::
113:,
109:,
105:,
101:,
97:,
6124:e
6117:t
6110:v
6049:)
6045:(
5898:/
5892:)
5791::
5766:)
5755:)
5730:)
5723:)
5712::
5700:)
5696:(
5690:)
5686:(
5680:)
5672:(
5662::
5622:e
5615:t
5608:v
5260:e
5253:t
5246:v
5169:e
5162:t
5155:v
5142:.
5121:.
5074:)
5070:(
5043:.
5019::
5013:8
4992:.
4968::
4941:.
4917::
4890:.
4868::
4841:.
4827::
4800:.
4776::
4749:.
4727::
4700:)
4686:.
4654::
4618:.
4594::
4564:.
4550::
4523:.
4509::
4482:.
4462::
4439:.
4425::
4419:4
4398:.
4376::
4349:.
4329::
4303:.
4261:.
4240:.
4207:.
4185::
4158:.
4144::
4117:.
4095::
4068:.
4054::
4027:.
4015::
3992:.
3970::
3943:.
3929::
3902:.
3878::
3872:2
3851:.
3837::
3810:.
3786::
3759:.
3735::
3708:.
3688::
3680::
3640:.
3626::
3599:.
3585::
3558:.
3544::
3517:.
3503::
3476:.
3456::
3429:.
3417::
3397:.
3373::
3365::
3338:.
3314::
3308:5
3274:.
3260::
3233:.
3209::
3182:.
3168::
3141:.
3119::
3092:.
3078::
3051:.
3029::
2983:.
2935:.
2921::
2889:.
2860:.
2833:.
2809::
2803:9
2782:.
2760::
2733:.
2709::
2682:.
2658::
2631:.
2607::
2580:.
2556::
2529:.
2511:.
2493:.
2475:.
2453::
2426:.
2385:.
2360:.
2335:.
2310:.
2288::
2261:.
2241::
2218:.
2206::
2180:.
2158::
2116:.
2102::
2096:7
2075:.
2057:.
1134:(
312:)
209:)
192::
34:.
20:)
Text is available under the Creative Commons Attribution-ShareAlike License. Additional terms may apply.
