271:(monocytes, macrophages, microglia, and dendritic cells) as viral reservoirs, perpetrators of disease, and depots for nanoformulated drug delivery. His work was foundational to building a field of investigation focused on lentiviral pathogenesis, diagnostics, and therapeutics. These advancements in immune transformation have led to new and effective management of neurodegenerative disease progression. Gendelman and his research team were among the first to develop laboratory assays for establishing
245:
in March 1993. He retired from the US Army with the rank of
Lieutenant Colonel. He established the Center for Neurovirology and Neurodegenerative Disorders at UNMC in 1997, which evolved into UNMC's current Department of Pharmacology and Experimental Neuroscience in 2004. In 2000, he was awarded a
79:
Startup of the Year 2022 UNeMed; Nebraska
Coalition for Lifesaving Cures' 2022 Life Saver Award; 2018 Jewish Federation of Omaha Humanitarian of the Year Award; 2017 Society on NeuroImmune Pharmacology Lifetime Achievement Award; International Society for NeuroVirology's 2016 Pioneer in
295:
end-organ disease. He coined the term long-acting slow effective release ART (LASER ART). These works led to polymer discovery, targeted drug delivery to viral reservoirs, and reduction of residual virus in lymphoid organs. His
Nebraska-based research group, along with a team at
316:, 2020). His work with cell-based drug delivery born out of nanoparticle-mononuclear phagocyte interactions has inspired broad pharmaceutical interest; in turn, Gendelman led the establishment of the Nebraska Nanomedicine Production Plant, a biotechnology
320:(cGMP) initiative, to position research for clinical translation in the development of long acting nanoformulated ART at UNMC. He also co-founded Exavir Therapeutics, Inc., a biotechnology company developing therapies towards and cure for HIV/AIDS.
1292:
Gendelman, Howard E.; Zhang, Yuning; Santamaria, Pamela; Olson, Katherine E.; Schutt, Charles R.; Bhatti, Danish; Shetty, Bhagya Laxmi Dyavar; Lu, Yaman; Estes, Katherine A.; Standaert, David G.; Heinrichs-Graham, Elizabeth (2017-03-23).
1044:
Kulkarni, Tanmay A.; Bade, Aditya N.; Sillman, Brady; Shetty, Bhagya Laxmi Dyavar; Wojtkiewicz, Melinda S.; Gautam, Nagsen; Hilaire, James R.; Sravanam, Sruthi; Szlachetka, Adam; Lamberty, Benjamin G.; Morsey, Brenda M. (August 2020).
1350:
Olson, Katherine E.; Namminga, Krista L.; Lu, Yaman; Schwab, Aaron D.; Thurston, Mackenzie J.; Abdelmoaty, Mai M.; Kumar, Vikas; Wojtkiewicz, Melinda; Obaro, Helen; Santamaria, Pamela; Mosley, R. Lee (2021-05-01).
238:
109:
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Gendelman, Howard E.; Zheng, Jialin; Coulter, Cynthia L.; Ghorpade, Anuja; Che, Myhanh; Thylin, Michael; Rubocki, Ronald; Persidsky, Yuri; Hahn, Francis; Reinhard, Jr., John; Swindells, Susan (October 1998).
664:
Koenig, Scott; Gendelman, Howard E.; Orenstein, Jan M.; Dal Canto, Mauro C.; Pezeshkpour, Gholam H.; Yungbluth, Margaret; Janotta, Frank; Aksamit, Allen; Martin, Malcolm A.; Fauci, Anthony S. (1986-09-05).
1224:
Benner, Eric J.; Mosley, R. Lee; Destache, Chris J.; Lewis, Travis B.; Jackson-Lewis, Vernice; Gorantla, Santhi; Nemachek, Craig; Green, Steven R.; Przedborski, Serge; Gendelman, Howard E. (2004-06-22).
979:
Dash, Prasanta K.; Kaminski, Rafal; Bella, Ramona; Su, Hang; Mathews, Saumi; Ahooyi, Taha M.; Chen, Chen; Mancuso, Pietro; Sariyer, Rahsan; Ferrante, Pasquale; Donadoni, Martina (December 2019).
1580:
275:
for mononuclear phagocytes, and they were the first to demonstrate that infected and immune activated mononuclear phagocytes release viral and cellular toxins that damage the nervous system.
1632:
150:(born March 18, 1954) is an American physician-scientist whose research intersects the disciplines of neuroimmunology, pharmacology, and infectious diseases. Gendelman was born in
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56:
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during the height of the HIV/AIDS pandemic. Gendelman also occupied senior faculty and research positions at the Johns
Hopkins Medical Institutions, the
1662:
1612:
601:"Production of acquired immunodeficiency syndrome-associated retrovirus in human and nonhuman cells transfected with an infectious molecular clone"
905:
1295:"Evaluation of the safety and immunomodulatory effects of sargramostim in a randomized, double-blind phase 1 clinical Parkinson's disease trial"
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113:
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pathway for HIV eradication. This work followed the first ultra-long acting nanocrystal prodrug and the world's first HIV vaccine mimetic (in
1642:
1462:
1427:
881:
242:
197:, where he graduated with a bachelor's degree in Natural Sciences and Russian Studies in 1975. He completed his doctorate of medicine at the
167:
104:
1657:
1408:
Gendelman, Howard E; Grant, Igor; Everall, Ian Paul; Fox, Howard S; Gelbard, Harris A; Lipton, Stuart A; Swindells, Susan, eds. (2012).
349:
206:
125:
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790:"Suppression of Inflammatory Neurotoxins by Highly Active Antiretroviral Therapy in Human Immunodeficiency Virus-Associated Dementia"
1652:
1667:
929:
372:
Lifetime
Achievement Award, Contribution to the Advancement of the Mission of the Society on NeuroImmune Pharmacology, 2017
1617:
251:
198:
1581:"$ 3 Million Grant Recognizes Potential of Research at the UNMC Center for Neurovirology and Neurodegenerative Disorders"
479:
1409:
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722:"Slow, persistent replication of lentiviruses: role of tissue macrophages and macrophage precursors in bone marrow"
1353:"Safety, tolerability, and immune-biomarker profiling for year-long sargramostim treatment of Parkinson's disease"
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Gendelman has written or edited 17 books and monographs (including multiple editions of the textbooks
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992:
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981:"Sequential LASER ART and CRISPR Treatments Eliminate HIV-1 in a Subset of Infected Humanized Mice"
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51:
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827:
646:
599:
Adachi, A; Gendelman, H E; Koenig, S; Folks, T; Willey, R; Rabson, A; Martin, M A (August 1986).
531:. University of Nebraska Medical Center, Department of Pharmacology and Experimental Neuroscience
510:. University of Nebraska Medical Center, Department of Pharmacology and Experimental Neuroscience
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to eliminate chronic viral infection from infected animals. This curative approach (published in
190:
60:
47:
1227:"Therapeutic immunization protects dopaminergic neurons in a mouse model of Parkinson's disease"
455:
1176:"Nebraska Nanomedicine Production Plant | Pharmacology | University of Nebraska Medical Center"
667:"Detection of AIDS Virus in Macrophages in Brain Tissue from AIDS Patients with Encephalopathy"
209:
in 1982, and he was a
Clinical and Research Fellow in Neurology and Infectious Diseases at the
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166:. He is the Margaret R. Larson Professor of infectious diseases and internal medicine at the
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Gendelman, H. E.; Narayan, O.; Molineaux, S.; Clements, J. E.; Ghotbi, Z. (October 1985).
1419:
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1062:
996:
956:"Researchers have eliminated HIV in mice for the first time. Is a cure for humans next?"
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336:. Phase II investigation began in early 2021 after successful phase I investigations
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in 1979. He then completed a residency in
Internal medicine at Montefiore Hospital,
397:
284:
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155:
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35:
616:
158:. His research is focused on harnessing immune responses for therapeutic gain in
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1231:
Proceedings of the
National Academy of Sciences of the United States of America
1004:
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Proceedings of the
National Academy of Sciences of the United States of America
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906:"Scientists say they found a cure for HIV in some mice. Humans could be next"
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and
Neuroimmune Pharmacology). He was the founding Editor-in-Chief of the
292:
159:
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375:
Pioneer in NeuroVirology, International Society for NeuroVirology, 2016
1110:
Soriano, Vicente; Barreiro, Pablo; de Mendoza, Carmen (August 2020).
871:
328:
Gendelman was the first to pharmacologically transform effector into
300:, was also the first to combine HIV reservoir-targeted LASER ART and
80:
NeuroVirology; 2000 J. William Fulbright Research Scholar; and others
568:
566:
239:
Henry M. Jackson Foundation for the Advancement in Military Medicine
140:
https://www.unmc.edu/pharmacology/faculty/primary-faculty/gendelman/
110:
Henry M. Jackson Foundation for the Advancement in Military Medicine
806:
789:
95:
Virology, neuroimmunology, neuroscience, pharmacology, therapeutics
1047:"A year-long extended release nanoformulated cabotegravir prodrug"
171:
308:, 2019) received considerable attention in establishing a novel
930:"In a first, scientists eliminate HIV from an animal's genome"
378:
Javits Investigator Award, National Institutes of Health, 2000
369:
Nebraska Coalition for Lifesaving Cures' 2022 Life Saver Award
291:(cART), and they developed scores of rodent models to mimic
71:
HIV research, Parkinson's research, neuroimmune-pharmacology
231:
Uniformed Services University of the Health Sciences Center
177:
He is married with three children and seven grandchildren.
118:
Uniformed Services University of the Health Sciences Center
550:"UNMC Professor gets Fulbright to study in Israel (2001)"
1531:"Tribute to Dr. Howard Gendelman and Dr. Bonnie Bloch"
227:
National Institute of Allergy and Infectious Diseases
263:
Mononuclear phagocytes and neurodegenerative disease
1443:Ikezu, Tsuneya; Gendelman, Howard E., eds. (2017).
424:"HIV eliminated from the genomes of living animals"
135:
99:
91:
75:
67:
43:
28:
21:
283:Gendelman's group was among the first to reverse
57:Pennsylvania State University College of Medicine
16:Scientist, HIV researcher, Parkinson's researcher
847:"Science Cafe explores possibility of HIV cure"
480:"Potential new HIV treatment developed at UNMC"
422:Temple University Health System (2019-07-02).
366:Startup of the Year 2022 - Exavir Therapeutics
323:
1633:University of Nebraska Medical Center faculty
8:
1557:"SNIP - Society on NeuroImmune Pharmacology"
324:Parkinson's Disease research contributions
267:Gendelman's research explores the role of
18:
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805:
763:
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578:International Society for NeurVirology
235:Walter Reed Army Institute of Research
114:Walter Reed Army Institute of Research
1585:University of Nebraska Medical Center
851:University of Nebraska Medical Center
396:Johnson, Amanda McGill (2022-01-28).
168:University of Nebraska Medical Center
105:University of Nebraska Medical Center
7:
1648:Pennsylvania State University alumni
1112:"Long-acting antiretroviral therapy"
574:"The Pioneer in Neurovirology Award"
460:The Jewish Community Center of Omaha
350:Journal of Neuroimmune Pharmacology
207:Albert Einstein College of Medicine
126:Albert Einstein College of Medicine
1420:10.1093/med/9780195399349.001.0001
794:The Journal of Infectious Diseases
289:combination antiretroviral therapy
14:
189:, on March 18, 1954. He attended
1663:21st-century American physicians
1613:20th-century American physicians
552:. Daily Nebraskan. 21 March 2000
1673:Parkinson's disease researchers
340:Scientific community leadership
241:before joining the faculty of
1:
870:Gendelman, Howard E. (2012).
845:Spellman, Lisa (2019-08-09).
617:10.1128/jvi.59.2.284-291.1986
454:Utesch, Margie (2018-07-03).
252:Weizmann Institute of Science
199:Pennsylvania State University
1643:Physicians from Pennsylvania
318:good manufacturing practices
287:in an infected person using
1658:People from Omaha, Nebraska
1414:. Oxford University Press.
1369:10.1016/j.ebiom.2021.103380
876:. Oxford University Press.
332:to halt the progression of
1689:
1005:10.1038/s41467-019-10366-y
456:"Humanitarian of the Year"
279:HIV research contributions
1638:Muhlenberg College alumni
1455:10.1007/978-3-319-44022-4
1311:10.1038/s41531-017-0013-5
1137:10.1038/s41563-020-0731-7
1071:10.1038/s41563-020-0674-z
398:"2022 Luncheon Honoreers"
164:Neurodegenerative disease
131:
84:
23:Howard E. Gendelman, M.D.
1653:Physicians from Nebraska
1505:"2022 Luncheon Honorees"
1446:Neuroimmune Pharmacology
225:Gendelman worked at the
181:Early life and education
122:Johns Hopkins University
1668:Medical journal editors
1299:npj Parkinson's Disease
1252:10.1073/pnas.0400569101
747:10.1073/pnas.82.20.7086
691:10.1126/science.3016903
195:Allentown, Pennsylvania
1204:exavirtherapeutics.com
910:www.washingtonpost.com
269:mononuclear phagocytes
250:to do research at the
211:Johns Hopkins Hospital
203:Hershey Medical Center
185:Gendelman was born in
1411:The Neurology of AIDS
1200:"Exavir Therapeutics"
985:Nature Communications
954:Yancey-Bragg, N'dea.
873:The neurology of AIDS
361:Research recognitions
346:The Neurology of AIDS
306:Nature Communications
1618:HIV/AIDS researchers
254:in Rehovot, Israel
38:, Pennsylvania, U.S.
1479:"Innovation Awards"
1243:2004PNAS..101.9435B
1128:2020NatMa..19..826S
1063:2020NatMa..19..910K
997:2019NatCo..10.2753D
738:1985PNAS...82.7086G
683:1986Sci...233.1089K
677:(4768): 1089–1093.
605:Journal of Virology
505:"Front Line (2009)"
428:Science Daily=en-US
334:Parkinson's disease
217:from 1982 to 1985.
148:Howard E. Gendelman
330:regulatory T cells
191:Muhlenberg College
48:Muhlenberg College
1511:. 28 January 2022
1485:. 23 October 2022
1464:978-3-319-44020-0
1429:978-0-19-996519-9
1237:(25): 9435–9440.
883:978-0-19-539934-9
732:(20): 7086–7090.
356:Awards and honors
298:Temple University
145:
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86:Scientific career
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1537:. Nebraska Cures
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611:(2): 284–291.
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