Knowledge (XXG)

IARC group 1 Carcinogens

Source šŸ“

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June 12, 2012 ā€ā€ After a week-long meeting of international experts, the International Agency for Research on Cancer (IARC), which is part of the World Health Organization (WHO), today classified diesel engine exhaust as carcinogenic to humans (Group 1), based on sufficient evidence that exposure is
87:) may be placed in this category when evidence of carcinogenicity in humans is less than sufficient, but when there is sufficient evidence of carcinogenicity in experimental animals and strong evidence in exposed humans that the agent (mixture) acts through a relevant mechanism of carcinogenicity. 1289:
November 2, 2009 ā€ā€ IARC has updated the cancer assessments of several personal habits and household exposures that cause cancer, including tobacco, areca nut, alcohol, and household coal smoke. The update was conducted with the advice of 30 scientists from 10 countries who met at IARC in October
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2009. The Working Group concluded that acetaldehyde associated with alcohol consumption is carcinogenic to humans (Group 1) and confirmed the classification in Group 1 of alcohol consumption and of ethanol in alcoholic beverages.
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A cancer hazard is an agent that is capable of causing cancer, whereas a cancer risk is an estimate of the probability that cancer will occur given some level of exposure to a cancer hazard.
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into account, which is the probability of causing a cancer, given the level of exposure to this carcinogen. The list is up to date as of January 2024.
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Specific radionuclides for which there is sufficient evidence for carcinogenicity to humans are also listed individually as Group 1 agents.
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There is also convincing evidence in humans that these agents confer a protective effect against cancer in the endometrium and ovary.
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This evaluation applies to the group of compounds as a whole and not necessarily to all individual compounds within the group.
322: 302: 238: 1380: 1361: 830:, with a Toxicity Equivalency Factor (TEF) according to WHO (PCBs 77, 81, 105, 114, 118, 123, 126, 156, 157, 167, 169, 189) 123: 117: 1007: 1409: 792:. An inverse association has been observed between estrogen-only menopausal therapy and cancer of the colorectum. 521: 351: 1218: 823: 630: 94:
linked to the agents. This means that while carcinogens are capable of causing cancer, it does not take their
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NB There is "evidence suggesting lack of carcinogenicity" for estrogen-only menopausal therapy in humans and
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List of Classifications by cancer sites with sufficient or limited evidence in humans, Volumes 1 to 124
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Overall evaluation upgraded to Group 1 with strong supporting evidence from other relevant data.
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types 16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58, and 59
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Agents Classified by the IARC Monographs, Volumes 1ā€“123
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of carcinogenicity in humans. Exceptionally, an agent (
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IARC Monographs on the Evaluation of Risk to Humans
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There is also conclusive evidence that this agent (
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Estrogen-progestogen oral contraceptives (combined)
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This category is used when there is 1124: 1122: 1120: 1118: 648:, Ī²-particle-emitting, internally deposited 642:, Ī±-particle-emitting, internally deposited 569:(1,1',1"-Phosphinothioylidynetrisaziridine) 77:International Agency for Research on Cancer 1417: 1403: 1395: 1359:Description of the list of classifications 1303:"IARC: Diesel Engine Exhaust Carcinogenic" 458:and other combined chemotherapy including 18: 1149: 1147: 1184: 1105: 870:, occupational exposure associated with 147:Kaposi's sarcoma-associated herpesvirus 594:Radiations and physical agents thereof 124:Human T-cell lymphotropic virus type I 1425:Cancer-causing materials and agents ( 7: 1066:Ultraviolet-emitting tanning devices 338:-Bis(2-chloroethyl)-2-naphthylamine) 450:4,4'-Methylenebis(2-chloroaniline) 56:Group 4: probably not carcinogenic 14: 711:(naturally occurring mixtures of) 500:2,3,4,7,8-Pentachlorodibenzofuran 313:1,4-Butanediol dimethanesulfonate 1584:Group 2B (possibly carcinogenic) 1579:Group 2A (probably carcinogenic) 786:Estrogen therapy, postmenopausal 419:Fluoro-edenite fibrous amphibole 505:3,4,5,3ā€™,4ā€™-Pentachlorobiphenyl 408:alone, and in combination with 212:associated with consumption of 993:manufacture using strong acids 1: 804:, untreated or mildly treated 1389:(Last update: 25 March 2019) 947:(occupational exposure as a) 873:Acid mists, strong inorganic 231:, and plants containing them 118:Human immunodeficiency virus 1453:Prominent human carcinogens 557:2,3,7,8-Tetrachlorodibenzo- 1631: 1589:Group 3 (not classifiable) 1383:(Last update: 8 July 2019) 840:Salted fish, Chinese-style 1434: 889:Boot and shoe manufacture 824:Polychlorinated biphenyls 737:, also known as betel nut 522:Polychlorinated biphenyls 352:Chloromethyl methyl ether 90:This list focuses on the 1615:IARC Group 1 carcinogens 1511:(e.g., from isotopes of 1017:Paving and roofing with 920:, indoor emissions from 631:Nuclear fission products 143:(chronic infection with) 137:(chronic infection with) 65:IARC group 1 Carcinogens 1375:List of Classifications 1251:monographs.iarc.who.int 703:Complex mixtures/agents 196:Schistosoma haematobium 120:type 1 (infection with) 47:: possibly carcinogenic 41:: probably carcinogenic 1574:Group 1 (carcinogenic) 1073:fumes and UV radiation 862:Exposure circumstances 771:Engine exhaust, diesel 683:and its decay products 672:and its decay products 666:and its decay products 660:and its decay products 654:and its decay products 518:(PFOA), evaluated 2023 516:Perfluorooctanoic acid 347:Bis(chloromethyl)ether 246:(all forms, including 188:Opisthorchis viverrini 1128:Evaluated as a group. 720:Outdoor air pollution 715:Outdoor air pollution 687:Ultraviolet radiation 107:Infectious conditions 1199:. IARC. July 7, 2019 315:(Busulphan, Myleran) 129:Human papillomavirus 1481:Helicobacter pylori 814:mixtures containing 730:Alcoholic beverages 494:-Nitrosonornicotine 396:alcoholic beverages 382:Diethylstilboestrol 377:1,2-Dichloropropane 361:Hexavalent chromium 303:beryllium compounds 214:alcoholic beverages 204:Chemical substances 180:Clonorchis sinensis 165:Helicobacter pylori 81:sufficient evidence 1509:Ionizing radiation 1499:Diethylstilbestrol 1364:2013-07-28 at the 1044:Tobacco, smokeless 997:Magenta production 817:Plants containing 724:particulate matter 600:Ionizing radiation 229:Aristolochic acids 152:Epsteinā€“Barr virus 53:: not classifiable 1597: 1596: 1528:Ultraviolet light 991:Isopropyl alcohol 913:Coal gasification 819:aristolochic acid 790:colorectal cancer 613:-32, as phosphate 606:Neutron radiation 578:Trichloroethylene 541:, in the form of 511:Pentachlorophenol 460:alkylating agents 323:cadmium compounds 239:arsenic compounds 141:Hepatitis C virus 135:Hepatitis B virus 75:to humans by the 69:chemical mixtures 62: 61: 1622: 1419: 1412: 1405: 1396: 1377:(latest version) 1346: 1345: 1343: 1341: 1336: 1328: 1322: 1321: 1315: 1313: 1307: 1299: 1293: 1292: 1286: 1284: 1278: 1270: 1261: 1260: 1258: 1257: 1243: 1237: 1236: 1231: 1229: 1223: 1215: 1209: 1208: 1206: 1204: 1189: 1172: 1169: 1163: 1160: 1154: 1151: 1142: 1135: 1129: 1126: 1113: 1110: 987:exposure during) 903:Chimney sweeping 891:and repair (see 836:(consumption of) 743:with or without 476:Nickel compounds 467:(Sulfur mustard) 429:Gallium arsenide 372:Cyclophosphamide 199:(infection with) 191:(infection with) 183:(infection with) 168:(infection with) 85:chemical mixture 67:are substances, 19: 1630: 1629: 1625: 1624: 1623: 1621: 1620: 1619: 1600: 1599: 1598: 1593: 1559: 1448: 1430: 1423: 1366:Wayback Machine 1355: 1350: 1349: 1339: 1337: 1334: 1330: 1329: 1325: 1311: 1309: 1306:(Press release) 1305: 1301: 1300: 1296: 1282: 1280: 1277:(Press release) 1276: 1272: 1271: 1264: 1255: 1253: 1245: 1244: 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995: 992: 989: 986: 982: 979: 975: 972: 970:(underground) 969: 966: 963: 960: 956: 952: 949: 946: 943: 940: 937: 935: 932: 929: 926: 923: 919: 916: 914: 911: 908: 904: 901: 898: 894: 890: 887: 884: 881: 878: 875: 872: 869: 866: 865: 861: 857: 854: 851: 848: 846: 843: 841: 838: 835: 832: 829: 825: 822: 820: 816: 813: 809: 806: 803: 800: 797: 794: 791: 787: 784: 782: 779: 777: 774: 772: 769: 766: 763: 759: 756: 754: 751: 748: 746: 742: 739: 736: 733: 731: 728: 725: 721: 718: 716: 713: 710: 707: 706: 702: 698: 694: 691: 688: 685: 682: 679: 677: 674: 671: 668: 665: 662: 659: 656: 653: 650: 647: 646:Radionuclides 644: 641: 640:Radionuclides 638: 636: 632: 629: 627: 623: 620: 618: 615: 612: 609: 607: 604: 601: 598: 597: 593: 589: 586: 584: 581: 579: 576: 574: 571: 568: 565: 562: 560: 555: 553: 550: 548: 544: 540: 536: 533: 530: 528: 525: 523: 520: 517: 514: 512: 509: 506: 503: 501: 498: 495: 493: 489: 486: 484: 479: 477: 474: 472: 469: 466: 463: 461: 457: 454: 451: 448: 445: 442: 440: 437: 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Retrieved 1196: 1187: 1167: 1158: 1133: 1108: 1094:IARC group 3 1012:occupational 985:occupational 957:making (see 934:distillation 802:Mineral oils 765:distillation 635:strontium-90 633:, including 624:, including 622:Radioiodines 558: 547:cristobalite 491: 482: 424:Formaldehyde 357:Chromium(VI) 342:Chlorambucil 335: 331: 274:Azathioprine 210:Acetaldehyde 194: 186: 178: 163: 89: 73:carcinogenic 64: 63: 32: 1610:Carcinogens 1548:Hepatitis C 1543:Hepatitis B 1489:Benzopyrene 1427:carcinogens 1004:consumption 945:Firefighter 828:dioxin-like 681:Thorium-232 602:(all types) 583:o-Toluidine 539:crystalline 465:Mustard gas 444:Methoxsalen 367:Ciclosporin 363:) compounds 294:Benzopyrene 264:crocidolite 1604:Categories 1340:26 October 1312:August 14, 1256:2024-02-01 1228:August 18, 1179:References 941:production 925:combustion 885:production 879:production 845:Shale-oils 808:Phenacetin 741:Betel quid 709:Aflatoxins 664:Radium-228 658:Radium-226 652:Radium-224 626:iodine-131 611:Phosphorus 573:Treosulfan 260:chrysotile 248:actinolite 219:Aflatoxins 25:monographs 1513:plutonium 1283:August 1, 1139:tamoxifen 965:Haematite 959:Wood dust 951:Furniture 922:household 877:Aluminium 856:Wood dust 812:analgesic 758:Coal-tars 735:Areca nut 670:Radon-222 617:Plutonium 552:Tamoxifen 527:Semustine 507:(PCB-126) 439:Melphalan 414:bleomycin 410:cisplatin 406:Etoposide 299:Beryllium 284:Benzidine 268:tremolite 158:Bacterium 1475:Bacteria 1470:Asbestos 1362:Archived 1203:July 14, 1078:See also 1040:industry 1026:Coal-tar 1019:coal-tar 981:founding 931:Coal-tar 883:Auramine 762:Coal-tar 750:Coal-tar 567:Thiotepa 387:Erionite 244:Asbestos 45:Group 2B 39:Group 2A 1533:Viruses 1465:Arsenic 1071:Welding 1061:smoking 1058:Tobacco 1049:Tobacco 1008:Painter 955:cabinet 897:Benzene 893:Leather 796:Leather 745:tobacco 561:-dioxin 434:Lindane 392:Ethanol 319:Cadmium 279:Benzene 252:amosite 235:Arsenic 112:Viruses 51:Group 3 33:Group 1 1517:radium 1439:Cancer 1035:Rubber 968:mining 895:dust, 563:(TCDD) 543:quartz 532:Silica 452:(MOCA) 286:, and 102:Agents 92:hazard 1567:lists 1335:(PDF) 1222:(PDF) 1100:Notes 1052:smoke 1029:pitch 1024:(see 1022:pitch 1002:Opium 978:steel 905:(see 760:(see 753:pitch 693:X-ray 496:(NNN) 487:(NNK) 173:Worms 1565:IARC 1515:and 1370:IARC 1342:2015 1314:2016 1285:2014 1230:2023 1205:2019 976:and 974:Iron 953:and 939:Coke 918:Coal 907:Soot 850:Soot 798:dust 695:and 535:dust 456:MOPP 412:and 321:and 301:and 288:dyes 96:risk 23:IARC 1553:HPV 545:or 481:4-( 394:in 1606:: 1368:, 1316:. 1287:. 1265:^ 1249:. 1232:. 1195:. 1146:^ 1117:^ 927:of 826:, 810:, 726:in 722:, 537:, 266:, 262:, 258:, 254:, 250:, 1519:) 1429:) 1418:e 1411:t 1404:v 1344:. 1259:. 1207:. 1031:) 1010:( 983:( 961:) 909:) 899:) 767:) 559:p 492:N 483:N 359:( 336:N 334:, 332:N 330:( 270:)

Index

IARC
Group 1
Group 2A
Group 2B
Group 3
chemical mixtures
carcinogenic
International Agency for Research on Cancer
sufficient evidence
chemical mixture
hazard
risk
Human immunodeficiency virus
Human T-cell lymphotropic virus type I
Human papillomavirus
Hepatitis B virus
Hepatitis C virus
Kaposi's sarcoma-associated herpesvirus
Epsteinā€“Barr virus
Helicobacter pylori
Clonorchis sinensis
Opisthorchis viverrini
Schistosoma haematobium
Acetaldehyde
alcoholic beverages
Aflatoxins
4-Aminobiphenyl
Aristolochic acids
Arsenic
arsenic compounds

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